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Tatsuya Tsukui, PhD

Photo of Tatsuya Tsukui, PhD
Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
AddressSan Francisco CA 94158
ORCID ORCID Icon0000-0003-3100-6934 Additional info
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    Collapse Biography 
    Collapse education and training
    UCSFPostdoc2021Medicine
    The University of TokyoPhD2016Medicine
    The University of TokyoMSc2012Medicine
    The University of TokyoBA2010Pharmaceutical Sciences
    Collapse awards and honors
    Japanese Society for Immunology2025Young Investigator Award
    GRC Lung Development, Injury & Repair2025Poster Presentation Award
    The Molecular Biology Society of Japan2024Travel Grants for Early Career Researchers Overseas
    American Lung Association2024Hastings Innovation Award for Interstitial Lung Disease
    American Thoracic Society2020RCMB Early Investigator Award in memory of Dr. Jo Rae Wright
    Keystone Symposia: Fibrosis and Tissue Repair2020Scholarship Award
    Japanese Society for Immunology2015Tadamitsu Kishimoto International Travel Award
    The Japanese Society of Inflammation and Regeneration2015International Travel Award

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    Role of pathologic fibroblast subsets unique to silicosis
    NIH R01HL180871Sep 15, 2025 - Jun 30, 2030
    Role: Principal Investigator
    Cellular and molecular delineation of pathologic fibroblasts in pulmonary fibrosis
    NIH R00HL155786Jul 10, 2023 - Jun 30, 2026
    Role: Principal Investigator
    Cellular and molecular delineation of pathologic fibroblasts in pulmonary fibrosis
    NIH K99HL155786Aug 5, 2021 - Jul 31, 2023
    Role: Principal Investigator
    California Foundation for Molecular Biology Frontiers in Medical Research fellowshipApr 1, 2019 - Mar 31, 2020
    Role: Principal Investigator
    Japan Society for the Promotion of Science Overseas Research FellowshipJun 1, 2017 - May 31, 2019
    Role: Principal Investigator
    Mochida Memorial Foundation for Medical and Pharmaceutical Research Grants-in-Aid for Overseas ResearchJan 1, 2017 - Mar 31, 2017
    Role: Principal Investigator
    Uehara Memorial Foundation Postdoctoral FellowshipJun 1, 2016 - May 31, 2017
    Role: Principal Investigator
    Japan Society for the Promotion of Science Research Fellowship for Young Scientists (DC1)Apr 1, 2013 - Mar 31, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Senolytic-sensitive p16Ink4a+ fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity. Cell Stem Cell. 2025 Nov 03. Lee JY, Reyes N, Woo SH, Allen NC, Kadota T, Lechner A, Biswas R, Goel S, Stratton F, Kuang C, Tsukui T, Auyeung V, Mansfield AS, LaFave LM, Peng T. PMID: 41187746.
      View in: PubMed   Mentions:
    2. Dynamic fibroblast-immune interactions shape recovery after brain injury. Nature. 2025 Oct; 646(8086):934-944. Ewing-Crystal NA, Mroz NM, Larpthaveesarp A, Lizama CO, Pennington R, Chiaranunt P, Dennis JI, Chang AA, Merrill ED, Caryotakis SE, Kirthivasan N, Teo L, Tsukui T, Katewa A, McKinsey GL, Nelson SCK, Ciesielska A, Lummis NC, Pintaric L, Dahlgren MW, Atakilit A, Paidassi H, Jain S, Liu X, Xu D, Aghi MK, Bourne JA, Paz JT, Daneman R, Gonzalez FF, Sheppard D, Molofsky AV, Arnold TD, Molofsky AB. PMID: 40903576; PMCID: PMC12545229.
      View in: PubMed   Mentions:    Fields:    
    3. Clonal expansion of alveolar fibroblast progeny drives pulmonary fibrosis in mouse models. J Clin Invest. 2025 Aug 28. Molina C, Tsukui T, Khan IS, Ren X, Qiu W, Matthay M, Wolters P, Sheppard D. PMID: 40875468.
      View in: PubMed   Mentions:    Fields:    
    4. Myeloid-mesenchymal crosstalk drives ARG1-dependent profibrotic metabolism via ornithine in lung fibrosis. J Clin Invest. 2025 Aug 28. Yadav P, Gómez Ortega J, Dabral P, Tamaki W, Chien C, Chang KC, Biswas N, Pan S, Nilsson J, Yin X, Bhattacharyya A, Boostanpour K, Jujaray T, Wang JT, Tsukui T, Molina CJ, Auyeung VC, Sheppard D, Li B, Maishan M, Taenaka H, Matthay MA, Muramatsu R, Maliskova L, Ghosh A, Eckalbar WL, Molofsky AB, Tamaki SJ, Bivona TG, Abate AR, Wagner A, Pillai SK, Wolters PJ, Tharp KM, Bhattacharya M. PMID: 40875483.
      View in: PubMed   Mentions:    Fields:    
    5. Resolving fibrosis by stimulating HSC-dependent extracellular matrix degradation. Sci Transl Med. 2025 Aug 27; 17(813):eads9470. Sharma S, Prathigudupu V, Cable C, Serrano LR, Nerella S, Chen A, Hassan G, Lakins J, Valenzuela CL, Tsukui T, Ramamoorthi R, Kim JJ, Willenbring H, Mattis AN, Volk RF, Zaro BW, Coon JJ, Beresis R, DeGrado WF, Weaver VM, Christenson SA, Jo H, Chen JY. PMID: 40864684; PMCID: PMC12474517.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Stromal heterogeneity in the adult lung delineated by single-cell genomics. Am J Physiol Cell Physiol. 2025 Jun 01; 328(6):C1964-C1972. Tsukui T, Sheppard D. PMID: 40353369.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition. Nature. 2025 Apr; 640(8057):221-230. Fang Y, Chung SSW, Xu L, Xue C, Liu X, Jiang D, Li R, Korogi Y, Yuan K, Saqi A, Hibshoosh H, Huang Y, Lin CS, Takarada T, Tsukui T, Sheppard D, Sun X, Que J. PMID: 39910313.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    8. Impaired myofibroblast proliferation is a central feature of pathologic post-natal alveolar simplification. Elife. 2024 Dec 11; 13. Khan IS, Molina C, Ren X, Auyeung VC, Cohen M, Tsukui T, Atakilit A, Sheppard D. PMID: 39660606; PMCID: PMC11634066.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    9. Macrophage-fibroblast crosstalk drives Arg1-dependent lung fibrosis via ornithine loading. bioRxiv. 2024 Jul 31. Yadav P, Ortega JG, Tamaki W, Chien C, Chang KC, Biswas N, Pan S, Nilsson J, Yin X, Bhattacharyya A, Boostanpour K, Jujaray T, Wang J, Tsukui T, Sheppard D, Li B, Maishan M, Taenaka H, Matthay MA, Muramatsu R, Maliskova L, Ghosh A, Eckalbar WL, Molofsky AB, Wolters PJ, Tamaki SJ, Bivona T, Abate AR, Wagner A, Tharp KM, Bhattacharya M. PMID: 39211079; PMCID: PMC11360891.
      View in: PubMed   Mentions:
    10. Alveolar fibroblast lineage orchestrates lung inflammation and fibrosis. Nature. 2024 Jul; 631(8021):627-634. Tsukui T, Wolters PJ, Sheppard D. PMID: 38987592; PMCID: PMC12088911.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    11. Dynamic fibroblast-immune interactions shape wound healing after brain injury. bioRxiv. 2024 Mar 15. Ewing-Crystal NA, Mroz NM, Chang AA, Merrill ED, Caryotakis SE, Teo L, Larpthaveesarp A, Tsukui T, Katewa A, Pennington R, McKinsey GL, Nelson S, Ciesielska A, Dahlgren MW, Paidassi H, Jain S, Aghi MK, Bourne JA, Paz JT, Gonzalez FF, Sheppard D, Molofsky AV, Arnold TD, Molofsky AB. PMID: 40093059; PMCID: PMC11908209.
      View in: PubMed   Mentions: 1  
    12. An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis. J Clin Invest. 2024 Mar 07; 134(9). Lee JY, Reyes NS, Ravishankar S, Zhou M, Krasilnikov M, Ringler C, Pohan G, Wilson C, Ang KK, Wolters PJ, Tsukui T, Sheppard D, Arkin MR, Peng T. PMID: 38451724; PMCID: PMC11060735.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    13. An immune-based tool platform for in vivo cell clearance. Life Sci Alliance. 2023 08; 6(8). Zhang J, Tsukui T, Wu X, Brito A, Trumble JM, Caraballo JC, Allen GM, Zavala-Solorio J, Zhang C, Paw J, Lim WA, Geng J, Kutskova Y, Freund A, Kolumam G, Sheppard D, Cohen RL. PMID: 37311583; PMCID: PMC10264967.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. Unique Glycoform-Dependent Monoclonal Antibodies for Mouse Mucin 21. Int J Mol Sci. 2022 Jun 16; 23(12). Nishida J, Shichino S, Tsukui T, Hoshino M, Okada T, Okada K, Yi Y, Toraya-Brown S, Mochizuki M, Koizumi R, Ishii-Schrade K, Denda-Nagai K, Irimura T. PMID: 35743163; PMCID: PMC9223859.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    15. Macrophage Cx43 Is Necessary for Fibroblast Cytosolic Calcium and Lung Fibrosis After Injury. Front Immunol. 2022; 13:880887. Bhattacharyya A, Torre P, Yadav P, Boostanpour K, Chen TY, Tsukui T, Sheppard D, Muramatsu R, Seed RI, Nishimura SL, Jung JB, Tang XZ, Allen CDC, Bhattacharya M. PMID: 35634278; PMCID: PMC9134074.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    16. Mucin 21 confers resistance to apoptosis in an O-glycosylation-dependent manner. Cell Death Discov. 2022 Apr 11; 8(1):194. Tian Y, Denda-Nagai K, Tsukui T, Ishii-Schrade KB, Okada K, Nishizono Y, Matsuzaki K, Hafley M, Bresalier RS, Irimura T. PMID: 35410995; PMCID: PMC9001685.
      View in: PubMed   Mentions: 9  
    17. Gene silencing by EZH2 suppresses TGF-β activity within the decidua to avert pregnancy-adverse wound healing at the maternal-fetal interface. Cell Rep. 2022 02 01; 38(5):110329. Osokine I, Siewiera J, Rideaux D, Ma S, Tsukui T, Erlebacher A. PMID: 35108527; PMCID: PMC8833843.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    18. Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy. Cell Rep. 2021 07 06; 36(1):109309. Dodagatta-Marri E, Ma HY, Liang B, Li J, Meyer DS, Chen SY, Sun KH, Ren X, Zivak B, Rosenblum MD, Headley MB, Pinzas L, Reed NI, Del Cid JS, Hann BC, Yang S, Giddabasappa A, Noorbehesht K, Yang B, Dal Porto J, Tsukui T, Niessen K, Atakilit A, Akhurst RJ, Sheppard D. PMID: 34233193; PMCID: PMC8321414.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    19. Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung. Nat Cell Biol. 2020 11; 22(11):1295-1306. Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, Wolters P, Molofsky A, Sheppard D, Chapman H, Peng T. PMID: 33046884; PMCID: PMC7642162.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    20. Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis. Nat Commun. 2020 04 21; 11(1):1920. Tsukui T, Sun KH, Wetter JB, Wilson-Kanamori JR, Hazelwood LA, Henderson NC, Adams TS, Schupp JC, Poli SD, Rosas IO, Kaminski N, Matthay MA, Wolters PJ, Sheppard D. PMID: 32317643; PMCID: PMC7174390.
      View in: PubMed   Mentions: 346     Fields:    Translation:HumansAnimalsCells
    21. Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking. Sci Adv. 2020 02; 6(7):eaay7667. Zhang Z, Bai M, Barbosa GO, Chen A, Wei Y, Luo S, Wang X, Wang B, Tsukui T, Li H, Sheppard D, Kornberg TB, Ma DK. PMID: 32095531; PMCID: PMC7015688.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    22. CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways. J Exp Med. 2019 12 02; 216(12):2748-2762. Wein AN, McMaster SR, Takamura S, Dunbar PR, Cartwright EK, Hayward SL, McManus DT, Shimaoka T, Ueha S, Tsukui T, Masumoto T, Kurachi M, Matsushima K, Kohlmeier JE. PMID: 31558615; PMCID: PMC6888981.
      View in: PubMed   Mentions: 192     Fields:    Translation:HumansAnimalsCells
    23. Gli signaling pathway modulates fibroblast activation and facilitates scar formation in pulmonary fibrosis. Biochem Biophys Res Commun. 2019 06 30; 514(3):684-690. Tsukui T, Ueha S, Shichino S, Hashimoto S, Nakajima T, Shiraishi K, Kihara M, Kiyonari H, Inagaki Y, Matsushima K. PMID: 31078262.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    24. Engraftment and proliferation potential of embryonic lung tissue cells in irradiated mice with emphysema. Sci Rep. 2019 03 06; 9(1):3657. Shiraishi K, Shichino S, Tsukui T, Hashimoto S, Ueha S, Matsushima K. PMID: 30842492; PMCID: PMC6403395.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCellsPHPublic Health
    25. Transcriptome network analysis identifies protective role of the LXR/SREBP-1c axis in murine pulmonary fibrosis. JCI Insight. 2019 Jan 10; 4(1). Shichino S, Ueha S, Hashimoto S, Otsuji M, Abe J, Tsukui T, Deshimaru S, Nakajima T, Kosugi-Kanaya M, Shand FH, Inagaki Y, Shimano H, Matsushima K. PMID: 30626759; PMCID: PMC6485671.
      View in: PubMed   Mentions: 25     Fields:    
    26. Lung fibroblasts express a miR-19a-19b-20a sub-cluster to suppress TGF-β-associated fibroblast activation in murine pulmonary fibrosis. Sci Rep. 2018 11 09; 8(1):16642. Souma K, Shichino S, Hashimoto S, Ueha S, Tsukui T, Nakajima T, Suzuki HI, Shand FHW, Inagaki Y, Nagase T, Matsushima K. PMID: 30413725; PMCID: PMC6226532.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    27. Fra-2 negatively regulates postnatal alveolar septation by modulating myofibroblast function. Am J Physiol Lung Cell Mol Physiol. 2017 Nov 01; 313(5):L878-L888. Tsujino K, Li JT, Tsukui T, Ren X, Bakiri L, Wagner E, Sheppard D. PMID: 28818870; PMCID: PMC6842869.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    28. Heat Shock Protein 27 Plays a Pivotal Role in Myofibroblast Differentiation and in the Development of Bleomycin-Induced Pulmonary Fibrosis. PLoS One. 2016; 11(2):e0148998. Park AM, Kanai K, Itoh T, Sato T, Tsukui T, Inagaki Y, Selman M, Matsushima K, Yoshie O. PMID: 26859835; PMCID: PMC4747463.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    29. Reduced supply of monocyte-derived macrophages leads to a transition from nodular to diffuse lesions and tissue cell activation in silica-induced pulmonary fibrosis in mice. Am J Pathol. 2015 Nov; 185(11):2923-38. Shichino S, Abe J, Ueha S, Otsuji M, Tsukui T, Kosugi-Kanaya M, Shand FH, Hashimoto S, Suzuki HI, Morikawa T, Inagaki Y, Matsushima K. PMID: 26456580.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    30. Intratracheal cell transfer demonstrates the profibrotic potential of resident fibroblasts in pulmonary fibrosis. Am J Pathol. 2015 Nov; 185(11):2939-48. Tsukui T, Ueha S, Shichino S, Inagaki Y, Matsushima K. PMID: 26456579.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    31. Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):7771-6. Shand FH, Ueha S, Otsuji M, Koid SS, Shichino S, Tsukui T, Kosugi-Kanaya M, Abe J, Tomura M, Ziogas J, Matsushima K. PMID: 24825888; PMCID: PMC4040600.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    32. Qualitative rather than quantitative changes are hallmarks of fibroblasts in bleomycin-induced pulmonary fibrosis. Am J Pathol. 2013 Sep; 183(3):758-73. Tsukui T, Ueha S, Abe J, Hashimoto S, Shichino S, Shimaoka T, Shand FH, Arakawa Y, Oshima K, Hattori M, Inagaki Y, Tomura M, Matsushima K. PMID: 23886891.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    33. Mucin 21 in esophageal squamous epithelia and carcinomas: analysis with glycoform-specific monoclonal antibodies. Glycobiology. 2012 Sep; 22(9):1218-26. Tian Y, Denda-Nagai K, Kamata-Sakurai M, Nakamori S, Tsukui T, Itoh Y, Okada K, Yi Y, Irimura T. PMID: 22611128.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    34. Chemokine receptor CXCR3 facilitates CD8(+) T cell differentiation into short-lived effector cells leading to memory degeneration. J Exp Med. 2011 Aug 01; 208(8):1605-20. Kurachi M, Kurachi J, Suenaga F, Tsukui T, Abe J, Ueha S, Tomura M, Sugihara K, Takamura S, Kakimi K, Matsushima K. PMID: 21788406; PMCID: PMC3149224.
      View in: PubMed   Mentions: 119     Fields:    Translation:AnimalsCells
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