Robert Edwards, MD

Title(s)Professor, Neurology
SchoolSchool of Medicine
Address600 16th St, #N272B
San Francisco CA 94158
ORCID ORCID Icon0000-0002-8650-3260 Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences

    Collapse Biography 
    Collapse Education and Training
    Yale, New HavenBA6/1/76Biology
    Johns HopkinsM.D.1980School of Medicine
    University of California, San Francisco , San FranciscoResidency 6/30/84Neurology
    University of California, San Francisco, San FranciscoPost-Doc Fellow/Scholar1990Biochemistry & Biophysics
    Collapse Awards and Honors
    NARSAD1993Established Investigator Award
    National Psychobiology Institute of Israel1998Smith Lectureship
    McGill2007FC McIntosh Lectureship
    Institute of Medicine2012Member
    Cahill Family2014Endowed chair
    Gordon Research Conferences2014Membrane Transport Proteins Chair
    UCSF Neurology2015Elliot Royer Award
    National Academy of Sciences2017Member
    Society for Neuroscience2017Special Lectureship
    Synuclein Meeting2018  - 2019Plenary Lecture
    Johns Hopkins2019Bard Lectureship

    Collapse Overview 
    Collapse Overview
    Robert Edwards is a neuroscientist known for his work on the molecular and cellular basis of neurotransmitter release and its role in Parkinson's disease. His group identified the proteins that transport classical transmitters into neurosecretory vesicles, characterizing their role in quantal release, their mechanism and their regulation as well as their structure. Using the transporters, he helped to establish the phenomenon of neurotransmitter corelease: his lab recently showed that individual neurons can release two transmitters with different frequency dependence, and the two vesicle populations recycle through distinct mechanisms. He has also used the transporters to elucidate the formation of dense core vesicles that mediate regulated release of peptides. Since the original identification of a vesicular monoamine transporter by selection in MPP+, his work has focused on the pathogenesis of Parkinson’s disease and most recently the function of presynaptic protein -synuclein, which has a central, causative role in the disorder. He also identified the first opioid receptor (delta-) and the transporters involved in glutamate recycling. The work in his lab has implications for behavior and neural degeneration, in particular Parkinson's disease.

    Robert Edwards was raised in New York City, attended Yale College and Johns Hopkins Medical School. He trained in clinical neurology, studied as a postdoctoral fellow with William J. Rutter at UCSF and joined the faculty at UCLA in 1990 before returning to UCSF in 1995. He is a member of the National Academy of Medicine and the National Academy of Sciences.

    Collapse Research 
    Collapse Research Activities and Funding
    The Function of Synuclein
    NIH R01NS109295Feb 1, 2019 - Jan 31, 2024
    Role: Principal Investigator
    Neurotransmitter Corelease
    NIH R01NS103938Sep 15, 2017 - May 31, 2022
    Role: Principal Investigator
    Structural Basis of Vesicular Neurotransmitter Transport
    NIH R01NS089713Aug 1, 2015 - Apr 30, 2024
    Role: Principal Investigator
    Proteomic Analysis of Synaptic Vesicle Pools
    NIH R21MH101704Jul 1, 2013 - Jun 30, 2015
    Role: Principal Investigator
    Formation of the Regulated Secretory Pathway
    NIH R01MH096863Jul 1, 2012 - Jun 30, 2017
    Role: Principal Investigator
    2010 and 2012 Membrane Transport Proteins
    NIH R13MH091834May 15, 2010 - Apr 14, 2013
    Role: Principal Investigator
    Alpha-Synuclein and the Synaptic Vesicle Cycle
    NIH R01NS062715Dec 1, 2009 - Nov 30, 2014
    Role: Principal Investigator
    Membrane Protein Expression Center
    NIH P50GM073210Sep 24, 2004 - Aug 31, 2015
    Role: Co-Investigator
    New Perspectives in Transporter Biology-FASEB Conference
    NIH R13DA016646Jun 1, 2003 - May 31, 2004
    Role: Principal Investigator
    Pharmacogenetics of Membrane Transporters
    NIH U01GM061390Apr 1, 2000 - Jul 14, 2010
    Role: Co-Investigator
    Transport of Neurotransmitters Into Synaptic Vesicles
    NIH K02MH001365Jul 1, 1996 - Aug 31, 2006
    Role: Principal Investigator
    Presynaptic Mechanisms of Neural Plasticity
    NIH P01DA010154Sep 30, 1995 - Apr 30, 2018
    Role: Principal Investigator
    Transport of Neurotransmitter Into Synaptic Vesicles
    NIH R37MH050712Jul 1, 1993 - May 31, 2021
    Role: Principal Investigator
    Transport of Neurotransmitter Into Synaptic Vesicles
    NIH R01MH050712Jul 1, 1993 - Jul 31, 2016
    Role: Principal Investigator
    NIH K08NS001146Jul 1, 1986 - Jun 30, 1991
    Role: Principal Investigator
    NIH F32NS007529Jul 1, 1985
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    Function and development in the synapse
    NIH P01NS016033Apr 1, 1980 - Jun 30, 2009
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Collaboration Interests

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Adaptor protein-3 produces synaptic vesicles that release phasic dopamine. Proc Natl Acad Sci U S A. 2023 10 17; 120(42):e2309843120. Jain S, Yee AG, Maas J, Gierok S, Xu H, Stansil J, Eriksen J, Nelson AB, Silm K, Ford CP, Edwards RH. PMID: 37812725; PMCID: PMC10589613.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    2. Adaptor protein AP-3 produces synaptic vesicles that release at high frequency by recruiting phospholipid flippase ATP8A1. Nat Neurosci. 2023 10; 26(10):1685-1700. Xu H, Oses-Prieto JA, Khvotchev M, Jain S, Liang J, Burlingame A, Edwards RH. PMID: 37723322.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Adaptor Protein-3 Produces Synaptic Vesicles that Release Phasic Dopamine. bioRxiv. 2023 Aug 08. Jain S, Yee AG, Maas J, Gierok S, Xu H, Stansil J, Eriksen J, Nelson A, Silm K, Ford CP, Edwards RH. PMID: 37609166; PMCID: PMC10441354.
      View in: PubMed   Mentions:
    4. Synuclein phosphorylation: pathogenic or physiologic? NPJ Parkinsons Dis. 2023 Mar 28; 9(1):47. Kontaxi C, Edwards RH. PMID: 36977661; PMCID: PMC10050171.
      View in: PubMed   Mentions:
    5. Substrate recognition and proton coupling by a bacterial member of solute carrier family 17. J Biol Chem. 2023 05; 299(5):104646. Batarni S, Nayak N, Chang A, Li F, Hareendranath S, Zhou L, Xu H, Stroud R, Eriksen J, Edwards RH. PMID: 36965620; PMCID: PMC10149257.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    6. High-speed imaging reveals the bimodal nature of dense core vesicle exocytosis. Proc Natl Acad Sci U S A. 2023 01 03; 120(1):e2214897120. Zhang P, Rumschitzki D, Edwards RH. PMID: 36574702; PMCID: PMC9910497.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    7. Diversity of function and mechanism in a family of organic anion transporters. Curr Opin Struct Biol. 2022 08; 75:102399. Li F, Eriksen J, Finer-Moore J, Stroud RM, Edwards RH. PMID: 35660266; PMCID: PMC9884543.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    8. SNX5 targets a monoamine transporter to the TGN for assembly into dense core vesicles by AP-3. J Cell Biol. 2022 05 02; 221(5). Xu H, Chang F, Jain S, Heller BA, Han X, Liu Y, Edwards RH. PMID: 35426896; PMCID: PMC9016777.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    9. Whole Endosome Recording of Vesicular Neurotransmitter Transporter Currents. Methods Mol Biol. 2022; 2417:29-44. Chang R, Edwards RH. PMID: 35099789.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. Allosteric Inhibition of a Vesicular Glutamate Transporter by an Isoform-Specific Antibody. Biochemistry. 2021 08 17; 60(32):2463-2470. Eriksen J, Li F, Stroud RM, Edwards RH. PMID: 34319067; PMCID: PMC8823281.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. The Membrane Interactions of Synuclein: Physiology and Pathology. Annu Rev Pathol. 2021 01 24; 16:465-485. Runwal G, Edwards RH. PMID: 33497259.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    12. A dual role for α-synuclein in facilitation and depression of dopamine release from substantia nigra neurons in vivo. Proc Natl Acad Sci U S A. 2020 12 22; 117(51):32701-32710. Somayaji M, Cataldi S, Choi SJ, Edwards RH, Mosharov EV, Sulzer D. PMID: 33273122; PMCID: PMC7768743.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    13. Ion transport and regulation in a synaptic vesicle glutamate transporter. Science. 2020 05 22; 368(6493):893-897. Li F, Eriksen J, Finer-Moore J, Chang R, Nguyen P, Bowen A, Myasnikov A, Yu Z, Bulkley D, Cheng Y, Edwards RH, Stroud RM. PMID: 32439795; PMCID: PMC7388591.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    14. The mechanism and regulation of vesicular glutamate transport: Coordination with the synaptic vesicle cycle. Biochim Biophys Acta Biomembr. 2020 12 01; 1862(12):183259. Eriksen J, Li F, Edwards RH. PMID: 32147354; PMCID: PMC7483692.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    15. Structures suggest a mechanism for energy coupling by a family of organic anion transporters. PLoS Biol. 2019 05; 17(5):e3000260. Leano JB, Batarni S, Eriksen J, Juge N, Pak JE, Kimura-Someya T, Robles-Colmenares Y, Moriyama Y, Stroud RM, Edwards RH. PMID: 31083648; PMCID: PMC6532931.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    16. Synaptic Vesicle Recycling Pathway Determines Neurotransmitter Content and Release Properties. Neuron. 2019 05 22; 102(4):786-800.e5. Silm K, Yang J, Marcott PF, Asensio CS, Eriksen J, Guthrie DA, Newman AH, Ford CP, Edwards RH. PMID: 31003725; PMCID: PMC6541489.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    17. The dual role of chloride in synaptic vesicle glutamate transport. Elife. 2018 07 24; 7. Chang R, Eriksen J, Edwards RH. PMID: 30040066; PMCID: PMC6057745.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    18. A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry. Nat Commun. 2018 01 23; 9(1):330. Ullman JC, Yang J, Sullivan M, Bendor J, Levy J, Pham E, Silm K, Seifikar H, Sohal VS, Nicoll RA, Edwards RH. PMID: 29362376; PMCID: PMC5780507.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    19. Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons. eNeuro. 2017 Mar-Apr; 4(2). Pathak D, Berthet A, Bendor JT, Yu K, Sellnow RC, Orr AL, Nguyen MK, Edwards RH, Manfredsson FP, Nakamura K. PMID: 28462393; PMCID: PMC5409983.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    20. α-Synuclein promotes dilation of the exocytotic fusion pore. Nat Neurosci. 2017 May; 20(5):681-689. Logan T, Bendor J, Toupin C, Thorn K, Edwards RH. PMID: 28288128; PMCID: PMC5404982.
      View in: PubMed   Mentions: 145     Fields:    Translation:HumansAnimalsCells
    21. Endogenous Leucine-Rich Repeat Kinase 2 Slows Synaptic Vesicle Recycling in Striatal Neurons. Front Synaptic Neurosci. 2017; 9:5. Maas JW, Yang J, Edwards RH. PMID: 28280464; PMCID: PMC5322269.
      View in: PubMed   Mentions: 12  
    22. One Cycle Fuels Another: The Energetics of Neurotransmitter Release. Neuron. 2017 Feb 08; 93(3):470-472. Silm K, Edwards RH. PMID: 28182901.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    23. A slow excitatory postsynaptic current mediated by a novel metabotropic glutamate receptor in CA1 pyramidal neurons. Neuropharmacology. 2017 03 15; 115:4-9. Sheng N, Yang J, Silm K, Edwards RH, Nicoll RA. PMID: 27567940.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    24. Sensory-Derived Glutamate Regulates Presynaptic Inhibitory Terminals in Mouse Spinal Cord. Neuron. 2016 06 15; 90(6):1189-1202. Mende M, Fletcher EV, Belluardo JL, Pierce JP, Bommareddy PK, Weinrich JA, Kabir ZD, Schierberl KC, Pagiazitis JG, Mendelsohn AI, Francesconi A, Edwards RH, Milner TA, Rajadhyaksha AM, van Roessel PJ, Mentis GZ, Kaltschmidt JA. PMID: 27263971; PMCID: PMC4912012.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    25. Protons Regulate Vesicular Glutamate Transporters through an Allosteric Mechanism. Neuron. 2016 05 18; 90(4):768-80. Eriksen J, Chang R, McGregor M, Silm K, Suzuki T, Edwards RH. PMID: 27133463; PMCID: PMC4886649.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    26. Sex-dependent changes in metabolism and behavior, as well as reduced anxiety after eliminating ventromedial hypothalamus excitatory output. Mol Metab. 2015 Nov; 4(11):857-66. Cheung CC, Krause WC, Edwards RH, Yang CF, Shah NM, Hnasko TS, Ingraham HA. PMID: 26629409; PMCID: PMC4632173.
      View in: PubMed   Mentions: 25     Fields:    
    27. The role of mitochondrially derived ATP in synaptic vesicle recycling. J Biol Chem. 2015 Sep 11; 290(37):22325-36. Pathak D, Shields LY, Mendelsohn BA, Haddad D, Lin W, Gerencser AA, Kim H, Brand MD, Edwards RH, Nakamura K. PMID: 26126824; PMCID: PMC4566209.
      View in: PubMed   Mentions: 128     Fields:    Translation:AnimalsCells
    28. Mobile binding sites regulate glutamate clearance. Nat Neurosci. 2015 Feb; 18(2):166-8. Edwards RH. PMID: 25622571.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    29. Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons. J Neurosci. 2014 Oct 22; 34(43):14304-17. Berthet A, Margolis EB, Zhang J, Hsieh I, Zhang J, Hnasko TS, Ahmad J, Edwards RH, Sesaki H, Huang EJ, Nakamura K. PMID: 25339743; PMCID: PMC4205554.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    30. Efficient, complete deletion of synaptic proteins using CRISPR. Neuron. 2014 Sep 03; 83(5):1051-7. Incontro S, Asensio CS, Edwards RH, Nicoll RA. PMID: 25155957; PMCID: PMC4195490.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    31. Self-assembly of VPS41 promotes sorting required for biogenesis of the regulated secretory pathway. Dev Cell. 2013 Nov 25; 27(4):425-37. Asensio CS, Sirkis DW, Maas JW, Egami K, To TL, Brodsky FM, Shu X, Cheng Y, Edwards RH. PMID: 24210660; PMCID: PMC3974617.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    32. Widespread dysregulation of peptide hormone release in mice lacking adaptor protein AP-3. PLoS Genet. 2013; 9(9):e1003812. Sirkis DW, Edwards RH, Asensio CS. PMID: 24086151; PMCID: PMC3784564.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    33. The function of α-synuclein. Neuron. 2013 Sep 18; 79(6):1044-66. Bendor JT, Logan TP, Edwards RH. PMID: 24050397; PMCID: PMC3866954.
      View in: PubMed   Mentions: 345     Fields:    Translation:HumansAnimals
    34. Multiple dileucine-like motifs direct VGLUT1 trafficking. J Neurosci. 2013 Jun 26; 33(26):10647-60. Foss SM, Li H, Santos MS, Edwards RH, Voglmaier SM. PMID: 23804088; PMCID: PMC3693054.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    35. Ventral tegmental area glutamate neurons: electrophysiological properties and projections. J Neurosci. 2012 Oct 24; 32(43):15076-85. Hnasko TS, Hjelmstad GO, Fields HL, Edwards RH. PMID: 23100428; PMCID: PMC3685320.
      View in: PubMed   Mentions: 136     Fields:    Translation:AnimalsCells
    36. Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy. Neuron. 2012 Jul 26; 75(2):283-93. Akil O, Seal RP, Burke K, Wang C, Alemi A, During M, Edwards RH, Lustig LR. PMID: 22841313; PMCID: PMC3408581.
      View in: PubMed   Mentions: 200     Fields:    Translation:AnimalsCells
    37. AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans. Cell Metab. 2012 Jul 03; 16(1):113-21. Cunningham KA, Hua Z, Srinivasan S, Liu J, Lee BH, Edwards RH, Ashrafi K. PMID: 22768843; PMCID: PMC3413480.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    38. Fabs enable single particle cryoEM studies of small proteins. Structure. 2012 Apr 04; 20(4):582-92. Wu S, Avila-Sakar A, Kim J, Booth DS, Greenberg CH, Rossi A, Liao M, Li X, Alian A, Griner SL, Juge N, Yu Y, Mergel CM, Chaparro-Riggers J, Strop P, Tampé R, Edwards RH, Stroud RM, Craik CS, Cheng Y. PMID: 22483106; PMCID: PMC3322386.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansCells
    39. Vesicular and plasma membrane transporters for neurotransmitters. Cold Spring Harb Perspect Biol. 2012 Feb 01; 4(2). Blakely RD, Edwards RH. PMID: 22199021; PMCID: PMC3281572.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    40. Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia. J Clin Invest. 2012 Feb; 122(2):507-18. Lee HY, Nakayama J, Xu Y, Fan X, Karouani M, Shen Y, Pothos EN, Hess EJ, Fu YH, Edwards RH, Ptácek LJ. PMID: 22214848; PMCID: PMC3533379.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    41. Neurotransmitter corelease: mechanism and physiological role. Annu Rev Physiol. 2012; 74:225-43. Hnasko TS, Edwards RH. PMID: 22054239; PMCID: PMC4090038.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansAnimalsCells
    42. Presynaptic regulation of quantal size: K+/H+ exchange stimulates vesicular glutamate transport. Nat Neurosci. 2011 Aug 28; 14(10):1285-92. Goh GY, Huang H, Ullman J, Borre L, Hnasko TS, Trussell LO, Edwards RH. PMID: 21874016; PMCID: PMC3183113.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    43. v-SNARE composition distinguishes synaptic vesicle pools. Neuron. 2011 Aug 11; 71(3):474-87. Hua Z, Leal-Ortiz S, Foss SM, Waites CL, Garner CC, Voglmaier SM, Edwards RH. PMID: 21835344; PMCID: PMC3155686.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    44. Pathway-specific genetic attenuation of glutamate release alters select features of competition-based visual circuit refinement. Neuron. 2011 Jul 28; 71(2):235-42. Koch SM, Dela Cruz CG, Hnasko TS, Edwards RH, Huberman AD, Ullian EM. PMID: 21791283; PMCID: PMC3375067.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    45. Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein. J Biol Chem. 2011 Jun 10; 286(23):20710-26. Nakamura K, Nemani VM, Azarbal F, Skibinski G, Levy JM, Egami K, Munishkina L, Zhang J, Gardner B, Wakabayashi J, Sesaki H, Cheng Y, Finkbeiner S, Nussbaum RL, Masliah E, Edwards RH. PMID: 21489994; PMCID: PMC3121472.
      View in: PubMed   Mentions: 300     Fields:    Translation:HumansAnimalsCells
    46. RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway. J Cell Biol. 2010 Dec 13; 191(6):1173-87. Asensio CS, Sirkis DW, Edwards RH. PMID: 21149569; PMCID: PMC3002028.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    47. Metabolic control of vesicular glutamate transport and release. Neuron. 2010 Oct 06; 68(1):99-112. Juge N, Gray JA, Omote H, Miyaji T, Inoue T, Hara C, Uneyama H, Edwards RH, Nicoll RA, Moriyama Y. PMID: 20920794; PMCID: PMC2978156.
      View in: PubMed   Mentions: 183     Fields:    Translation:HumansAnimalsCells
    48. Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate. J Neurosci. 2010 Jun 16; 30(24):8229-33. Stuber GD, Hnasko TS, Britt JP, Edwards RH, Bonci A. PMID: 20554874; PMCID: PMC2918390.
      View in: PubMed   Mentions: 296     Fields:    Translation:AnimalsCells
    49. Vesicular monoamine and glutamate transporters select distinct synaptic vesicle recycling pathways. J Neurosci. 2010 Jun 09; 30(23):7917-27. Onoa B, Li H, Gagnon-Bartsch JA, Elias LA, Edwards RH. PMID: 20534840; PMCID: PMC3184447.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    50. Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo. Neuron. 2010 Mar 11; 65(5):643-56. Hnasko TS, Chuhma N, Zhang H, Goh GY, Sulzer D, Palmiter RD, Rayport S, Edwards RH. PMID: 20223200; PMCID: PMC2846457.
      View in: PubMed   Mentions: 234     Fields:    Translation:HumansAnimalsCells
    51. Glutamate co-release at GABA/glycinergic synapses is crucial for the refinement of an inhibitory map. Nat Neurosci. 2010 Feb; 13(2):232-8. Noh J, Seal RP, Garver JA, Edwards RH, Kandler K. PMID: 20081852; PMCID: PMC2832847.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    52. Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. Neuron. 2010 Jan 14; 65(1):66-79. Nemani VM, Lu W, Berge V, Nakamura K, Onoa B, Lee MK, Chaudhry FA, Nicoll RA, Edwards RH. PMID: 20152114; PMCID: PMC3119527.
      View in: PubMed   Mentions: 536     Fields:    Translation:HumansAnimalsCells
    53. Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors. Nature. 2009 Dec 03; 462(7273):651-5. Seal RP, Wang X, Guan Y, Raja SN, Woodbury CJ, Basbaum AI, Edwards RH. PMID: 19915548; PMCID: PMC2810205.
      View in: PubMed   Mentions: 207     Fields:    Translation:AnimalsCells
    54. Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminals. Science. 2009 Jun 12; 324(5933):1441-4. Gubernator NG, Zhang H, Staal RG, Mosharov EV, Pereira DB, Yue M, Balsanek V, Vadola PA, Mukherjee B, Edwards RH, Sulzer D, Sames D. PMID: 19423778; PMCID: PMC6696931.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    55. Synaptic and extrasynaptic factors governing glutamatergic retinal waves. Neuron. 2009 Apr 30; 62(2):230-41. Blankenship AG, Ford KJ, Johnson J, Seal RP, Edwards RH, Copenhagen DR, Feller MB. PMID: 19409268; PMCID: PMC2807181.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    56. Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons. Neuron. 2009 Apr 30; 62(2):218-29. Mosharov EV, Larsen KE, Kanter E, Phillips KA, Wilson K, Schmitz Y, Krantz DE, Kobayashi K, Edwards RH, Sulzer D. PMID: 19409267; PMCID: PMC2677560.
      View in: PubMed   Mentions: 246     Fields:    Translation:HumansAnimalsCells
    57. What the neuron tells glia. Neuron. 2009 Mar 26; 61(6):811-2. Edwards R. PMID: 19323989.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    58. Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria. J Neurosci. 2008 Nov 19; 28(47):12305-17. Nakamura K, Nemani VM, Wallender EK, Kaehlcke K, Ott M, Edwards RH. PMID: 19020024; PMCID: PMC6671709.
      View in: PubMed   Mentions: 103     Fields:    Translation:AnimalsCells
    59. Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3. Neuron. 2008 Jan 24; 57(2):263-75. Seal RP, Akil O, Yi E, Weber CM, Grant L, Yoo J, Clause A, Kandler K, Noebels JL, Glowatzki E, Lustig LR, Edwards RH. PMID: 18215623; PMCID: PMC2293283.
      View in: PubMed   Mentions: 181     Fields:    Translation:AnimalsCells
    60. Pharmacology of neurotransmitter transport into secretory vesicles. Handb Exp Pharmacol. 2008; (184):77-106. Chaudhry FA, Boulland JL, Jenstad M, Bredahl MK, Edwards RH. PMID: 18064412.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    61. Vesicular neurotransmitter transporters as targets for endogenous and exogenous toxic substances. Annu Rev Pharmacol Toxicol. 2008; 48:277-301. Chaudhry FA, Edwards RH, Fonnum F. PMID: 17883368.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    62. The neurotransmitter cycle and quantal size. Neuron. 2007 Sep 20; 55(6):835-58. Edwards RH. PMID: 17880890.
      View in: PubMed   Mentions: 159     Fields:    Translation:HumansAnimalsCells
    63. Physiology versus pathology in Parkinson's disease. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):11867-8. Nakamura K, Edwards RH. PMID: 17623781; PMCID: PMC1924576.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    64. Vesicular glutamate transporter 1 is required for photoreceptor synaptic signaling but not for intrinsic visual functions. J Neurosci. 2007 Jul 04; 27(27):7245-55. Johnson J, Fremeau RT, Duncan JL, Rentería RC, Yang H, Hua Z, Liu X, LaVail MM, Edwards RH, Copenhagen DR. PMID: 17611277; PMCID: PMC2443709.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    65. Thyronamines inhibit plasma membrane and vesicular monoamine transport. ACS Chem Biol. 2007 Jun 15; 2(6):390-8. Snead AN, Santos MS, Seal RP, Miyakawa M, Edwards RH, Scanlan TS. PMID: 17530732.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    66. Do different endocytic pathways make different synaptic vesicles? Curr Opin Neurobiol. 2007 Jun; 17(3):374-80. Voglmaier SM, Edwards RH. PMID: 17449236.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    67. Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis. J Neurosci. 2006 Nov 15; 26(46):11915-22. Larsen KE, Schmitz Y, Troyer MD, Mosharov E, Dietrich P, Quazi AZ, Savalle M, Nemani V, Chaudhry FA, Edwards RH, Stefanis L, Sulzer D. PMID: 17108165; PMCID: PMC6674868.
      View in: PubMed   Mentions: 216     Fields:    Translation:AnimalsCells
    68. Synaptic vesicles: half full or half empty? Neuron. 2006 Sep 07; 51(5):523-4. Hnasko TS, Edwards RH. PMID: 16950150.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    69. Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling. Neuron. 2006 Jul 06; 51(1):71-84. Voglmaier SM, Kam K, Yang H, Fortin DL, Hua Z, Nicoll RA, Edwards RH. PMID: 16815333.
      View in: PubMed   Mentions: 216     Fields:    Translation:AnimalsCells
    70. PharmGKB submission update: VI. PMT submissions of genetic variations in neurotransmitter transporters (SLC6, SLC17, and SLC18) to the PharmGKB network. Pharmacol Rev. 2006 Mar; 58(1):5-6. Badagnani I, Sorani M, Edwards RH, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Carlson EJ, Taylor T, Chan W, De La Cruz M, Ferrin TE, Burchard EG, Herskowitz I, Kroetz DL, Giacomini KM. PMID: 16507879.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    71. Functional implications of neurotransmitter co-release: glutamate and GABA share the load. Curr Opin Pharmacol. 2006 Feb; 6(1):114-9. Seal RP, Edwards RH. PMID: 16359920.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    72. Sorting of vesicular monoamine transporter 2 to the regulated secretory pathway confers the somatodendritic exocytosis of monoamines. Neuron. 2005 Nov 23; 48(4):619-33. Li H, Waites CL, Staal RG, Dobryy Y, Park J, Sulzer DL, Edwards RH. PMID: 16301178.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    73. Neural activity controls the synaptic accumulation of alpha-synuclein. J Neurosci. 2005 Nov 23; 25(47):10913-21. Fortin DL, Nemani VM, Voglmaier SM, Anthony MD, Ryan TA, Edwards RH. PMID: 16306404; PMCID: PMC6725870.
      View in: PubMed   Mentions: 139     Fields:    Translation:AnimalsCells
    74. A combinatorial code for the interaction of alpha-synuclein with membranes. J Biol Chem. 2005 Sep 09; 280(36):31664-72. Kubo S, Nemani VM, Chalkley RJ, Anthony MD, Hattori N, Mizuno Y, Edwards RH, Fortin DL. PMID: 16020543.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    75. Antidepressants and the monoamine masquerade. Neuron. 2005 Apr 07; 46(1):1-2. Sulzer D, Edwards RH. PMID: 15820686.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    76. Expression of the vesicular glutamate transporters during development indicates the widespread corelease of multiple neurotransmitters. J Comp Neurol. 2004 Dec 13; 480(3):264-80. Boulland JL, Qureshi T, Seal RP, Rafiki A, Gundersen V, Bergersen LH, Fremeau RT, Edwards RH, Storm-Mathisen J, Chaudhry FA. PMID: 15515175.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    77. Normal biogenesis and cycling of empty synaptic vesicles in dopamine neurons of vesicular monoamine transporter 2 knockout mice. Mol Biol Cell. 2005 Jan; 16(1):306-15. Croft BG, Fortin GD, Corera AT, Edwards RH, Beaudet A, Trudeau LE, Fon EA. PMID: 15496457; PMCID: PMC539174.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    78. Vesicular glutamate transporter 3 expression identifies glutamatergic amacrine cells in the rodent retina. J Comp Neurol. 2004 Sep 27; 477(4):386-98. Johnson J, Sherry DM, Liu X, Fremeau RT, Seal RP, Edwards RH, Copenhagen DR. PMID: 15329888; PMCID: PMC2586940.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    79. The effect of rare human sequence variants on the function of vesicular monoamine transporter 2. Pharmacogenetics. 2004 Sep; 14(9):587-94. Burman J, Tran CH, Glatt C, Freimer NB, Edwards RH. PMID: 15475732.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    80. Lipid rafts mediate the synaptic localization of alpha-synuclein. J Neurosci. 2004 Jul 28; 24(30):6715-23. Fortin DL, Troyer MD, Nakamura K, Kubo S, Anthony MD, Edwards RH. PMID: 15282274; PMCID: PMC6729723.
      View in: PubMed   Mentions: 233     Fields:    Translation:HumansAnimalsCells
    81. Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites. Science. 2004 Jun 18; 304(5678):1815-9. Fremeau RT, Kam K, Qureshi T, Johnson J, Copenhagen DR, Storm-Mathisen J, Chaudhry FA, Nicoll RA, Edwards RH. PMID: 15118123.
      View in: PubMed   Mentions: 215     Fields:    Translation:AnimalsCells
    82. VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate. Trends Neurosci. 2004 Feb; 27(2):98-103. Fremeau RT, Voglmaier S, Seal RP, Edwards RH. PMID: 15102489.
      View in: PubMed   Mentions: 325     Fields:    Translation:HumansAnimalsCells
    83. Plasma membrane and vesicular glutamate transporter mRNAs/proteins in hypothalamic neurons that regulate body weight. Eur J Neurosci. 2003 Sep; 18(5):1265-78. Collin M, Bäckberg M, Ovesjö ML, Fisone G, Edwards RH, Fujiyama F, Meister B. PMID: 12956725.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    84. Organic anion transport is the primary function of the SLC17/type I phosphate transporter family. Pflugers Arch. 2004 Feb; 447(5):629-35. Reimer RJ, Edwards RH. PMID: 12811560.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimals
    85. The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons. J Neurosci. 2003 Feb 15; 23(4):1265-75. Wreden CC, Johnson J, Tran C, Seal RP, Copenhagen DR, Reimer RJ, Edwards RH. PMID: 12598615; PMCID: PMC6742289.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    86. Vesicular neurotransmitter transporter expression in developing postnatal rodent retina: GABA and glycine precede glutamate. J Neurosci. 2003 Jan 15; 23(2):518-29. Johnson J, Tian N, Caywood MS, Reimer RJ, Edwards RH, Copenhagen DR. PMID: 12533612; PMCID: PMC6741860.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    87. The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14488-93. Fremeau RT, Burman J, Qureshi T, Tran CH, Proctor J, Johnson J, Zhang H, Sulzer D, Copenhagen DR, Storm-Mathisen J, Reimer RJ, Chaudhry FA, Edwards RH. PMID: 12388773; PMCID: PMC137910.
      View in: PubMed   Mentions: 201     Fields:    Translation:HumansAnimalsCells
    88. The glutamine commute: take the N line and transfer to the A. J Cell Biol. 2002 Apr 29; 157(3):349-55. Chaudhry FA, Reimer RJ, Edwards RH. PMID: 11980913; PMCID: PMC2173294.
      View in: PubMed   Mentions: 84     Fields:    Translation:Cells
    89. Glutamine uptake by neurons: interaction of protons with system a transporters. J Neurosci. 2002 Jan 01; 22(1):62-72. Chaudhry FA, Schmitz D, Reimer RJ, Larsson P, Gray AT, Nicoll R, Kavanaugh M, Edwards RH. PMID: 11756489; PMCID: PMC6757603.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
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