 Maggie Waung, MD
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| Title(s) | Assistant Professor, Neurology |
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| School | School of Medicine |
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| vCard | Download vCard |
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| Title(s) | UCSF Weill Institute for Neurosciences |
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 Biography | University of California San Francisco | Residency | 2014 | Neurology | | University of Texas Southwestern Medical Center | MD, PhD | 2010 | Medicine, Neuroscience | | Wellesley College | B.A. | 2002 | Physics |
| University of California San Francisco | 2016
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| 2017 | Weill Neuroscience Scholar | | American Headache Society | 2016 | | Frontiers in Headache Medicine Scholarship Award | | San Francisco Neurological Society | 2016 | | Newman Award for Best Clinical Neurology Paper | | Association of Migraine Disorders | 2014
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| 2015 | Basic Headache Research Grant Recipient | | American Academy of Neurology | 2010 | | Medical Student Prize for Excellence in Neurology |
Overview My career goal is to broaden the understanding of central pain processing to develop targeted, novel therapeutics for specific headache syndromes. My experiences with patients who experience migraines prompted me to think more deeply about concepts of pain and central sensitization. Migraineurs have exquisite sensitivity to external stimuli, and headaches seem to be triggered by pain pathways that may have undergone maladaptive changes. Additionally, long-term acute medication use promotes the severity and frequency of migraines, which can become refractory to treatment. Because migraines can worsen over time, this indicates plastic changes in circuitry may be potential targets for new therapies.
I am currently employing state of the art optogenetic methods combined with ex vivo brain slice whole cell physiology and pharmacology to interrogate specific circuits implicated in migraine pathophysiology. Evaluating changes in these circuits in response to headache or analgesic use will provide much needed insight into clinical conditions such as chronic migraine and medication overuse headache, fulfilling an underserved translational need in the area of headache.
Research Bibliographic
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Waung MW, Margolis EB, Charbit AR, Fields HL. A Midbrain Circuit that Mediates Headache Aversiveness in Rats. Cell Rep. 2019 Sep 10; 28(11):2739-2747.e4. PMID: 31509737.
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Berger A, Litwin J, Allen IE, Qubty W, Irwin S, Waung M, Gelfand AA. Preliminary Evidence that Melatonin Is not a Biomarker in Children and Adolescents With Episodic Migraine. Headache. 2019 May 03. PMID: 31054199.
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Waung MW, Akerman S, Wakefield M, Keywood C, Goadsby PJ. Metabotropic glutamate receptor 5: a target for migraine therapy. Ann Clin Transl Neurol. 2016 08; 3(8):560-71. PMID: 27606340.
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Byers CE, Barylko B, Ross JA, Southworth DR, James NG, Taylor CA, Wang L, Collins KA, Estrada A, Waung M, Tassin TC, Huber KM, Jameson DM, Albanesi JP. Enhancement of dynamin polymerization and GTPase activity by Arc/Arg3.1. Biochim Biophys Acta. 2015 Jun; 1850(6):1310-8. PMID: 25783003.
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Waung MW, Abrams GM. Combat-related headache and traumatic brain injury. Curr Pain Headache Rep. 2012 Dec; 16(6):533-8. PMID: 22956047.
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Waung MW, Grossman AW, Barmada SJ, Josephson SA, Dillon WP, Ralph JW. Pearls & oy-sters: the use of CT venography in Hirayama disease. Neurology. 2012 Jul 31; 79(5):e38-40. PMID: 22851722; PMCID: PMC3405252.
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Waung MW, Singer MA. An unusual case of Miller Fisher syndrome presenting with proptosis and chemosis. Muscle Nerve. 2012 May; 45(5):764-6. PMID: 22499110.
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Waung MW, Huber KM. Protein translation in synaptic plasticity: mGluR-LTD, Fragile X. Curr Opin Neurobiol. 2009 Jun; 19(3):319-26. PMID: 19411173.
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Waung MW, Pfeiffer BE, Nosyreva ED, Ronesi JA, Huber KM. Rapid translation of Arc/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate. Neuron. 2008 Jul 10; 59(1):84-97. PMID: 18614031.
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