Ken Nakamura, MD, PhD
Title(s) | UCSF Weill Institute for Neurosciences |
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Overview Dr. Ken Nakamura is a neurologist who specializes in diagnosing and treating patients with Parkinson’s disease at the Parkinson’s Disease and Movement Disorders Clinic. He also runs a research laboratory at the Gladstone Institutes, where he investigates how disruptions of mitochondria—the “power centers” of cells that convert nutrients into energy—contribute to the development and progression of Parkinson’s disease and Alzheimer’s disease.
Nakamura earned a bachelor’s degree in chemistry and biological sciences from Cornell University, and an MD and PhD in neurobiology from the University of Chicago. His thesis work focused on the role of oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson’s disease. Nakamura then completed an internship in internal medicine and a residency in neurology at UCSF, and a clinical fellowship in movement disorders at UCSF and the San Francisco VA Medical Center. He also completed a research fellowship at UCSF, during which he investigated how alpha-synuclein disrupts mitochondrial morphology and function and contributes to the development of Parkinson’s disease. He has received several awards, including a Burroughs Wellcome Fund Career Award for Medical Scientists.
Research ORNG Applications Bibliographic
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Defining the ATPome reveals cross-optimization of metabolic pathways. Nat Commun. 2020 08 28; 11(1):4319.
Bennett NK, Nguyen MK, Darch MA, Nakaoka HJ, Cousineau D, Ten Hoeve J, Graeber TG, Schuelke M, Maltepe E, Kampmann M, Mendelsohn BA, Nakamura JL, Nakamura K. PMID: 32859923.
View in: PubMed Mentions: 1 Fields: Translation: HumansCells
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Loss of HIPK2 Protects Neurons from Mitochondrial Toxins by Regulating Parkin Protein Turnover. J Neurosci. 2020 01 15; 40(3):557-568.
Zhang J, Shang Y, Kamiya S, Kotowski SJ, Nakamura K, Huang EJ. PMID: 31776210.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
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To be or not to be pink(1): contradictory findings in an animal model for Parkinson's disease. Brain Commun. 2019; 1(1):fcz016.
de Haas R, Heltzel LCMW, Tax D, van den Broek P, Steenbreker H, Verheij MMM, Russel FGM, Orr AL, Nakamura K, Smeitink JAM. PMID: 31667474.
View in: PubMed Mentions:
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A high-throughput screen of real-time ATP levels in individual cells reveals mechanisms of energy failure. PLoS Biol. 2018 08; 16(8):e2004624.
Mendelsohn BA, Bennett NK, Darch MA, Yu K, Nguyen MK, Pucciarelli D, Nelson M, Horlbeck MA, Gilbert LA, Hyun W, Kampmann M, Nakamura JL, Nakamura K. PMID: 30148842.
View in: PubMed Mentions: 9 Fields: Translation: HumansCells
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Mapping the Genetic Landscape of Human Cells. Cell. 2018 08 09; 174(4):953-967.e22.
Horlbeck MA, Xu A, Wang M, Bennett NK, Park CY, Bogdanoff D, Adamson B, Chow ED, Kampmann M, Peterson TR, Nakamura K, Fischbach MA, Weissman JS, Gilbert LA. PMID: 30033366.
View in: PubMed Mentions: 31 Fields: Translation: HumansCells
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A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling. Cell Syst. 2017 12 27; 5(6):564-577.e12.
Malty RH, Aoki H, Kumar A, Phanse S, Amin S, Zhang Q, Minic Z, Goebels F, Musso G, Wu Z, Abou-Tok H, Meyer M, Deineko V, Kassir S, Sidhu V, Jessulat M, Scott NE, Xiong X, Vlasblom J, Prasad B, Foster LJ, Alberio T, Garavaglia B, Yu H, Bader GD, Nakamura K, Parkinson J, Babu M. PMID: 29128334.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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Understanding the susceptibility of dopamine neurons to mitochondrial stressors in Parkinson's disease. FEBS Lett. 2015 Dec 21; 589(24 Pt A):3702-13.
Haddad D, Nakamura K. PMID: 26526613.
View in: PubMed Mentions: 23 Fields: Translation: HumansAnimalsCells
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The role of mitochondrially derived ATP in synaptic vesicle recycling. J Biol Chem. 2015 Sep 11; 290(37):22325-36.
Pathak D, Shields LY, Mendelsohn BA, Haddad D, Lin W, Gerencser AA, Kim H, Brand MD, Edwards RH, Nakamura K. PMID: 26126824.
View in: PubMed Mentions: 52 Fields: Translation: AnimalsCells
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Dynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons. Cell Death Dis. 2015 Apr 16; 6:e1725.
Shields LY, Kim H, Zhu L, Haddad D, Berthet A, Pathak D, Lam M, Ponnusamy R, Diaz-Ramirez LG, Gill TM, Sesaki H, Mucke L, Nakamura K. PMID: 25880092.
View in: PubMed Mentions: 29 Fields: Translation: AnimalsCells
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Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons. J Neurosci. 2014 Oct 22; 34(43):14304-17.
Berthet A, Margolis EB, Zhang J, Hsieh I, Zhang J, Hnasko TS, Ahmad J, Edwards RH, Sesaki H, Huang EJ, Nakamura K. PMID: 25339743.
View in: PubMed Mentions: 61 Fields: Translation: AnimalsCells
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Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies. J Neurosci. 2014 Jan 08; 34(2):418-33.
PMID: 24403142.
View in: PubMed Mentions: 57 Fields: Translation: HumansCells
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SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK. Aging (Albany NY). 2013 Nov; 5(11):835-49.
PMID: 24296486.
View in: PubMed Mentions: 49 Fields: Translation: HumansAnimalsCells
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Energy failure: does it contribute to neurodegeneration? Ann Neurol. 2013 Oct; 74(4):506-16.
PMID: 24038413.
View in: PubMed Mentions: 41 Fields: Translation: HumansAnimalsCells
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The ubiquitin ligase parkin mediates resistance to intracellular pathogens. Nature. 2013 Sep 26; 501(7468):512-6.
PMID: 24005326.
View in: PubMed Mentions: 190 Fields: Translation: AnimalsCells
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A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1. Cell. 2013 Aug 15; 154(4):737-47.
PMID: 23953109.
View in: PubMed Mentions: 59 Fields: Translation: HumansAnimalsCells
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a-Synuclein and mitochondria: partners in crime? Neurotherapeutics. 2013 Jul; 10(3):391-9.
PMID: 23512373.
View in: PubMed Mentions: 43 Fields: Translation: HumansAnimalsCells
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Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):E1604-12.
PMID: 23564345.
View in: PubMed Mentions: 71 Fields: Translation: HumansAnimalsCells
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Mitochondrial dynamics in neurodegeneration. Trends Cell Biol. 2013 Feb; 23(2):64-71.
PMID: 23159640.
View in: PubMed Mentions: 159 Fields: Translation: HumansAnimalsCells
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Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein. J Biol Chem. 2011 Jun 10; 286(23):20710-26.
Nakamura K, Nemani VM, Azarbal F, Skibinski G, Levy JM, Egami K, Munishkina L, Zhang J, Gardner B, Wakabayashi J, Sesaki H, Cheng Y, Finkbeiner S, Nussbaum RL, Masliah E, Edwards RH. PMID: 21489994.
View in: PubMed Mentions: 206 Fields: Translation: HumansAnimalsCells
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Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. Neuron. 2010 Jan 14; 65(1):66-79.
Nemani VM, Lu W, Berge V, Nakamura K, Onoa B, Lee MK, Chaudhry FA, Nicoll RA, Edwards RH. PMID: 20152114.
View in: PubMed Mentions: 366 Fields: Translation: HumansAnimalsCells
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The behavior of alpha-synuclein in neurons. Mov Disord. 2010; 25 Suppl 1:S21-6.
Fortin DL, Nemani VM, Nakamura K, Edwards RH. PMID: 20187244.
View in: PubMed Mentions: 12 Fields: Translation: HumansCells
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Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria. J Neurosci. 2008 Nov 19; 28(47):12305-17.
Nakamura K, Nemani VM, Wallender EK, Kaehlcke K, Ott M, Edwards RH. PMID: 19020024.
View in: PubMed Mentions: 77 Fields: Translation: AnimalsCells
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Effects of unilateral subthalamic and pallidal deep brain stimulation on fine motor functions in Parkinson's disease. Mov Disord. 2007 Apr 15; 22(5):619-26.
Nakamura K, Christine CW, Starr PA, Marks WJ. PMID: 17230483.
View in: PubMed Mentions: 13 Fields: Translation: Humans
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Huntington's disease: clinical characteristics, pathogenesis and therapies. Drugs Today (Barc). 2007 Feb; 43(2):97-116.
Nakamura K, Aminoff MJ. PMID: 17353947.
View in: PubMed Mentions: 7 Fields: Translation: HumansCells
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Textbook of neural repair and rehabilitation (eds Selzer ME, Cohen L, Gage FH, Clarke S and Duncan PW). Trophic factor delivery by gene therapy. 2006; 532-547.
Nakamura K
Kang UJ. .
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Lipid rafts mediate the synaptic localization of alpha-synuclein. J Neurosci. 2004 Jul 28; 24(30):6715-23.
Fortin DL, Troyer MD, Nakamura K, Kubo S, Anthony MD, Edwards RH. PMID: 15282274.
View in: PubMed Mentions: 163 Fields: Translation: HumansAnimalsCells
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Vitamin B12 deficiency. Arch Neurol. 2004 Jun; 61(6):960.
Nakamura K, Mukherjee P, Swanson RA. PMID: 15210541.
View in: PubMed Mentions: 1 Fields: Translation: Humans
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Polyneuropathy following gastric bypass surgery. Am J Med. 2003 Dec 01; 115(8):679-80.
Nakamura K, Roberson ED, Reilly LG, Tsao JW. PMID: 14656629.
View in: PubMed Mentions: 2 Fields: Translation: Humans
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Potential of gene therapy for pediatric neurotransmitter diseases: lessons from Parkinson's disease. Ann Neurol. 2003; 54 Suppl 6:S103-9.
Kang UJ, Nakamura K. PMID: 12891660.
View in: PubMed Mentions: 1 Fields: Translation: Humans
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The localization and functional contribution of striatal aromatic L-amino acid decarboxylase to L-3,4-dihydroxyphenylalanine decarboxylation in rodent parkinsonian models. Cell Transplant. 2000 Sep-Oct; 9(5):567-76.
Nakamura K, Ahmed M, Barr E, Leiden JM, Kang UJ. PMID: 11144954.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
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Preferential resistance of dopaminergic neurons to glutathione depletion in a reconstituted nigrostriatal system. Brain Res. 2000 Aug 11; 873(2):203-11.
Nakamura K, Won L, Heller A, Kang UJ. PMID: 10930545.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
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The selective toxicity of 1-methyl-4-phenylpyridinium to dopaminergic neurons: the role of mitochondrial complex I and reactive oxygen species revisited. Mol Pharmacol. 2000 Aug; 58(2):271-8.
Nakamura K, Bindokas VP, Marks JD, Wright DA, Frim DM, Miller RJ, Kang UJ. PMID: 10908294.
View in: PubMed Mentions: 22 Fields: Translation: AnimalsCells
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Preferential resistance of dopaminergic neurons to the toxicity of glutathione depletion is independent of cellular glutathione peroxidase and is mediated by tetrahydrobiopterin. J Neurochem. 2000 Jun; 74(6):2305-14.
Nakamura K, Wright DA, Wiatr T, Kowlessur D, Milstien S, Lei XG, Kang UJ. PMID: 10820190.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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The role of glutathione in dopaminergic neuronal survival. J Neurochem. 1997 Nov; 69(5):1850-8.
Nakamura K, Wang W, Kang UJ. PMID: 9349527.
View in: PubMed Mentions: 19 Fields: Translation: AnimalsCells
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Year | Publications |
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1997 | 1 | 2000 | 4 | 2003 | 2 | 2004 | 2 | 2006 | 1 | 2007 | 2 | 2008 | 1 | 2010 | 2 | 2011 | 1 | 2012 | 1 | 2013 | 6 | 2014 | 2 | 2015 | 3 | 2017 | 1 | 2018 | 2 | 2019 | 2 | 2020 | 1 |
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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