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Francesca Nesta Delling, MD, MPH

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Phone415-353-2873
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    Collapse Biography 
    Collapse Education and Training
    Universita' di Brescia School of MedicineM.D.1998Medicine
    Cardiac Ultrasound Laboratory, Massachusetts General HospitalFellow2004Echocardiography
    Boston University Medical CenterResident2007Medicine
    Beth Israel Deaconess Medical CenterFellow2010Cardiovascular Medicine
    Harvard T.H. Chan School of Public HealthM.P.H.2016Public Health
    Collapse Awards and Honors
    American Heart Association2004Samuel A. Levine Young Clinical Investigator Award finalist

    Collapse Overview 
    Collapse Overview
    CLINICAL
    Dr Delling is a cardiologist with advanced training in echocardiography and cardiac magnetic resonance imaging (MRI). She completed internal medicine residency at Boston University Medical Center and cardiovascular and cardiac imaging fellowships at Beth Israel Deaconess Medical Center and Massachusetts General Hospital. Her clinical interests include valvular heart disease (with a focus on mitral valve prolapse), primary and secondary cardiomyopathies and sudden cardiac death related to valvular disease.

    RESEARCH
    Dr Delling's research has focused on mitral valve disease and the combined use of echocardiography, cardiac MRI, and molecular genetics as tools to better understand disease mechanisms and progression. She is currently an NIH-funded investigator (previously supported by the American Heart Association) with collaborators at the Framingham Heart Study and the Leducq MITRAL Network in Europe. Attended coursework essential for her research endeavors includes a Master in Public Health (Harvard T.H. Chan School of Public Health).

    Collapse Research 
    Collapse Research Activities and Funding
    Sudden cardiac death in mitral valve prolapse: a genotype-phenotype study
    NIH R03HL145238Sep 17, 2018 - Aug 31, 2020
    Role: Principal Investigator
    Genetic Determinants and Progression of Mitral Valve Prolapse
    NIH K23HL116652Jan 17, 2014 - Dec 31, 2018
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
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    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Toomer KA, Yu M, Fulmer D, Guo L, Moore KS, Moore R, Drayton KD, Glover J, Peterson N, Ramos-Ortiz S, Drohan A, Catching BJ, Stairley R, Wessels A, Lipschutz JH, Delling FN, Jeunemaitre X, Dina C, Collins RL, Brand H, Talkowski ME, Del Monte F, Mukherjee R, Awgulewitsch A, Body S, Hardiman G, Hazard ES, da Silveira WA, Wang B, Leyne M, Durst R, Markwald RR, Le Scouarnec S, Hagege A, Le Tourneau T, Kohl P, Rog-Zielinska EA, Ellinor PT, Levine RA, Milan DJ, Schott JJ, Bouatia-Naji N, Slaugenhaupt SA, Norris RA. Primary cilia defects causing mitral valve prolapse. Sci Transl Med. 2019 May 22; 11(493). PMID: 31118289.
      View in: PubMed
    2. Delling FN, Vittinghoff E, Dewland TA, Pletcher MJ, Olgin JE, Nah G, Aschbacher K, Fang CD, Lee ES, Fan SM, Kazi DS, Marcus GM. Does cannabis legalisation change healthcare utilisation? A population-based study using the healthcare cost and utilisation project in Colorado, USA. BMJ Open. 2019 May 15; 9(5):e027432. PMID: 31092662.
      View in: PubMed
    3. Yu M, Georges A, Tucker NR, Kyryachenko S, Toomer K, Schott JJ, Delling FN, Fernandez-Friera L, Solis J, Ellinor PT, Levine RA, Slaugenhaupt SA, Hagège AA, Dina C, Jeunemaitre X, Milan DJ, Norris RA, Bouatia-Naji N. Genome-Wide Association Study-Driven Gene-Set Analyses, Genetic, and Functional Follow-Up Suggest GLIS1 as a Susceptibility Gene for Mitral Valve Prolapse. Circ Genom Precis Med. 2019 May; 12(5):e002497. PMID: 31112420.
      View in: PubMed
    4. Benjamin EJ, Muntner P, Alonso A, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Chang AR, Cheng S, Das SR, Delling FN, Djousse L, Elkind MSV, Ferguson JF, Fornage M, Jordan LC, Khan SS, Kissela BM, Knutson KL, Kwan TW, Lackland DT, Lewis TT, Lichtman JH, Longenecker CT, Loop MS, Lutsey PL, Martin SS, Matsushita K, Moran AE, Mussolino ME, O'Flaherty M, Pandey A, Perak AM, Rosamond WD, Roth GA, Sampson UKA, Satou GM, Schroeder EB, Shah SH, Spartano NL, Stokes A, Tirschwell DL, Tsao CW, Turakhia MP, VanWagner LB, Wilkins JT, Wong SS, Virani SS. Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association. Circulation. 2019 03 05; 139(10):e56-e528. PMID: 30700139.
      View in: PubMed
    5. Ermakov S, Gulhar R, Lim L, Bibby D, Fang Q, Nah G, Abraham TP, Schiller NB, Delling FN. Left ventricular mechanical dispersion predicts arrhythmic risk in mitral valve prolapse. Heart. 2019 Feb 12. PMID: 30755467.
      View in: PubMed
    6. Le Tourneau T, Le Scouarnec S, Cueff C, Bernstein D, Aalberts JJJ, Lecointe S, Mérot J, Bernstein JA, Oomen T, Dina C, Karakachoff M, Desal H, Al Habash O, Delling FN, Capoulade R, Suurmeijer AJH, Milan D, Norris RA, Markwald R, Aikawa E, Slaugenhaupt SA, Jeunemaitre X, Hagège A, Roussel JC, Trochu JN, Levine RA, Kyndt F, Probst V, Le Marec H, Schott JJ. New insights into mitral valve dystrophy: a Filamin-A genotype-phenotype and outcome study. Eur Heart J. 2018 Apr 14; 39(15):1269-1277. PMID: 29020406.
      View in: PubMed
    7. Addison D, Lawler PR, Emami H, Janjua SA, Staziaki PV, Hallett TR, Hennessy O, Lee H, Szilveszter B, Lu M, Mousavi N, Nayor MG, Delling FN, Romero JM, Wirth LJ, Chan AW, Hoffmann U, Neilan TG. Incidental Statin Use and the Risk of Stroke or Transient Ischemic Attack after Radiotherapy for Head and Neck Cancer. J Stroke. 2018 Jan; 20(1):71-79. PMID: 29402065.
      View in: PubMed
    8. Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang AR, Cheng S, Chiuve SE, Cushman M, Delling FN, Deo R, de Ferranti SD, Ferguson JF, Fornage M, Gillespie C, Isasi CR, Jiménez MC, Jordan LC, Judd SE, Lackland D, Lichtman JH, Lisabeth L, Liu S, Longenecker CT, Lutsey PL, Mackey JS, Matchar DB, Matsushita K, Mussolino ME, Nasir K, O'Flaherty M, Palaniappan LP, Pandey A, Pandey DK, Reeves MJ, Ritchey MD, Rodriguez CJ, Roth GA, Rosamond WD, Sampson UKA, Satou GM, Shah SH, Spartano NL, Tirschwell DL, Tsao CW, Voeks JH, Willey JZ, Wilkins JT, Wu JH, Alger HM, Wong SS, Muntner P. Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart Association. Circulation. 2018 03 20; 137(12):e67-e492. PMID: 29386200.
      View in: PubMed
    9. Parwani P, Avierinos JF, Levine RA, Delling FN. Mitral Valve Prolapse: Multimodality Imaging and Genetic Insights. Prog Cardiovasc Dis. 2017 Nov - Dec; 60(3):361-369. PMID: 29122631.
      View in: PubMed
    10. Delling FN, Li X, Li S, Yang Q, Xanthakis V, Martinsson A, Andell P, Lehman BT, Osypiuk EW, Stantchev P, Zöller B, Benjamin EJ, Sundquist K, Vasan RS, Smith JG. Heritability of Mitral Regurgitation: Observations From the Framingham Heart Study and Swedish Population. Circ Cardiovasc Genet. 2017 Oct; 10(5). PMID: 28993406.
      View in: PubMed
    11. Basha TA, Akçakaya M, Liew C, Tsao CW, Delling FN, Addae G, Ngo L, Manning WJ, Nezafat R. Clinical performance of high-resolution late gadolinium enhancement imaging with compressed sensing. J Magn Reson Imaging. 2017 12; 46(6):1829-1838. PMID: 28301075.
      View in: PubMed
    12. Kato S, Nakamori S, Roujol S, Delling FN, Akhtari S, Jang J, Basha T, Berg S, Kissinger KV, Goddu B, Manning WJ, Nezafat R. Relationship between native papillary muscle T1 time and severity of functional mitral regurgitation in patients with non-ischemic dilated cardiomyopathy. J Cardiovasc Magn Reson. 2016 Nov 16; 18(1):79. PMID: 27846845.
      View in: PubMed
    13. Bui AH, Roujol S, Foppa M, Kissinger KV, Goddu B, Hauser TH, Zimetbaum PJ, Ngo LH, Manning WJ, Nezafat R, Delling FN. Diffuse myocardial fibrosis in patients with mitral valve prolapse and ventricular arrhythmia. Heart. 2017 02; 103(3):204-209. PMID: 27515954.
      View in: PubMed
    14. Delling FN, Rong J, Larson MG, Lehman B, Fuller D, Osypiuk E, Stantchev P, Hackman B, Manning WJ, Benjamin EJ, Levine RA, Vasan RS. Evolution of Mitral Valve Prolapse: Insights From the Framingham Heart Study. Circulation. 2016 Apr 26; 133(17):1688-95. PMID: 27006478.
      View in: PubMed
    15. Delling FN, Hassan ZK, Piatkowski G, Tsao CW, Rajabali A, Markson LJ, Zimetbaum PJ, Manning WJ, Chang JD, Mukamal KJ. Tricuspid Regurgitation and Mortality in Patients With Transvenous Permanent Pacemaker Leads. Am J Cardiol. 2016 Mar 15; 117(6):988-92. PMID: 26833208.
      View in: PubMed
    16. Levine RA, Hagége AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, Beaudoin J, Bischoff J, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Le Marec H, Le Tourneau T, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E, Slaugenhaupt SA, Song JK, Yacoub MH. Mitral valve disease--morphology and mechanisms. Nat Rev Cardiol. 2015 Dec; 12(12):689-710. PMID: 26483167.
      View in: PubMed
    17. Delling FN, Rong J, Larson MG, Lehman B, Osypiuk E, Stantchev P, Slaugenhaupt SA, Benjamin EJ, Levine RA, Vasan RS. Response to Letter Regarding Article, "Familial Clustering of Mitral Valve Prolapse in the Community". Circulation. 2015 Oct 06; 132(14):e187-8. PMID: 26438779.
      View in: PubMed
    18. Delling FN. Left Ventricular Ejection Index as a Marker of Early Myocardial Dysfunction in Primary Mitral Regurgitation: Novel or Old in Disguise? Circ Cardiovasc Imaging. 2015 Sep; 8(9):e003995. PMID: 26338880; PMCID: PMC4563999.
      View in: PubMed, PubMed Central
    19. Dina C, Bouatia-Naji N, Tucker N, Delling FN, Toomer K, Durst R, Perrocheau M, Fernandez-Friera L, Solis J, Le Tourneau T, Chen MH, Probst V, Bosse Y, Pibarot P, Zelenika D, Lathrop M, Hercberg S, Roussel R, Benjamin EJ, Bonnet F, Lo SH, Dolmatova E, Simonet F, Lecointe S, Kyndt F, Redon R, Le Marec H, Froguel P, Ellinor PT, Vasan RS, Bruneval P, Markwald RR, Norris RA, Milan DJ, Slaugenhaupt SA, Levine RA, Schott JJ, Hagege AA, Jeunemaitre X. Genetic association analyses highlight biological pathways underlying mitral valve prolapse. Nat Genet. 2015 Oct; 47(10):1206-11. PMID: 26301497.
      View in: PubMed
    20. Durst R, Sauls K, Peal DS, deVlaming A, Toomer K, Leyne M, Salani M, Talkowski ME, Brand H, Perrocheau M, Simpson C, Jett C, Stone MR, Charles F, Chiang C, Lynch SN, Bouatia-Naji N, Delling FN, Freed LA, Tribouilloy C, Le Tourneau T, LeMarec H, Fernandez-Friera L, Solis J, Trujillano D, Ossowski S, Estivill X, Dina C, Bruneval P, Chester A, Schott JJ, Irvine KD, Mao Y, Wessels A, Motiwala T, Puceat M, Tsukasaki Y, Menick DR, Kasiganesan H, Nie X, Broome AM, Williams K, Johnson A, Markwald RR, Jeunemaitre X, Hagege A, Levine RA, Milan DJ, Norris RA, Slaugenhaupt SA. Mutations in DCHS1 cause mitral valve prolapse. Nature. 2015 Sep 03; 525(7567):109-13. PMID: 26258302.
      View in: PubMed
    21. Motiwala SR, Delling FN. Assessment of mitral valve disease: a review of imaging modalities. Curr Treat Options Cardiovasc Med. 2015 Jul; 17(7):390. PMID: 25981195.
      View in: PubMed
    22. Delling FN, Vasan RS. Mitral valve prolapse and glaucoma: a 'floppy' perception? Heart. 2015 Apr; 101(8):584-5. PMID: 25637370.
      View in: PubMed
    23. Delling FN, Rong J, Larson MG, Lehman B, Osypiuk E, Stantchev P, Slaugenhaupt SA, Benjamin EJ, Levine RA, Vasan RS. Familial clustering of mitral valve prolapse in the community. Circulation. 2015 Jan 20; 131(3):263-8. PMID: 25361552.
      View in: PubMed
    24. Delling FN, Vasan RS. Epidemiology and pathophysiology of mitral valve prolapse: new insights into disease progression, genetics, and molecular basis. Circulation. 2014 May 27; 129(21):2158-70. PMID: 24867995.
      View in: PubMed
    25. Delling FN, Gona P, Larson MG, Lehman B, Manning WJ, Levine RA, Benjamin EJ, Vasan RS. Mild expression of mitral valve prolapse in the Framingham offspring: expanding the phenotypic spectrum. J Am Soc Echocardiogr. 2014 Jan; 27(1):17-23. PMID: 24206636.
      View in: PubMed
    26. Appelbaum E, Maron BJ, Adabag S, Hauser TH, Lesser JR, Haas TS, Riley AB, Harrigan CJ, Delling FN, Udelson JE, Gibson CM, Manning WJ, Maron MS. Intermediate-signal-intensity late gadolinium enhancement predicts ventricular tachyarrhythmias in patients with hypertrophic cardiomyopathy. Circ Cardiovasc Imaging. 2012 Jan; 5(1):78-85. PMID: 22135401.
      View in: PubMed
    27. Delling FN, Kang LL, Yeon SB, Kissinger KV, Goddu B, Manning WJ, Han Y. CMR predictors of mitral regurgitation in mitral valve prolapse. JACC Cardiovasc Imaging. 2010 Oct; 3(10):1037-45. PMID: 20947049.
      View in: PubMed
    28. Beeri R, Yosefy C, Guerrero JL, Nesta F, Abedat S, Chaput M, del Monte F, Handschumacher MD, Stroud R, Sullivan S, Pugatsch T, Gilon D, Vlahakes GJ, Spinale FG, Hajjar RJ, Levine RA. Mitral regurgitation augments post-myocardial infarction remodeling failure of hypertrophic compensation. J Am Coll Cardiol. 2008 Jan 29; 51(4):476-86. PMID: 18222360.
      View in: PubMed
    29. Delling FN, Sanborn DY, Levine RA, Picard MH, Fifer MA, Palacios IF, Lowry PA, Vlahakes GJ, Vaturi M, Hung J. Frequency and mechanism of persistent systolic anterior motion and mitral regurgitation after septal ablation in obstructive hypertrophic cardiomyopathy. Am J Cardiol. 2007 Dec 01; 100(11):1691-5. PMID: 18036370.
      View in: PubMed
    30. Syed Z, Leeds D, Curtis D, Nesta F, Levine RA, Guttag J. A framework for the analysis of acoustical cardiac signals. IEEE Trans Biomed Eng. 2007 Apr; 54(4):651-62. PMID: 17405372.
      View in: PubMed
    31. Syed Z, Curtis D, Guttag J, Nesta F, Levine RA. Software enhanced learning of cardiac auscultation. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:6105-8. PMID: 17946356.
      View in: PubMed
    32. Nesta F, Leyne M, Yosefy C, Simpson C, Dai D, Marshall JE, Hung J, Slaugenhaupt SA, Levine RA. New locus for autosomal dominant mitral valve prolapse on chromosome 13: clinical insights from genetic studies. Circulation. 2005 Sep 27; 112(13):2022-30. PMID: 16172273.
      View in: PubMed
    33. Sebag IA, Morgan JG, Handschumacher MD, Marshall JE, Nesta F, Hung J, Picard MH, Levine RA. Usefulness of three-dimensionally guided assessment of mitral stenosis using matrix-array ultrasound. Am J Cardiol. 2005 Oct 15; 96(8):1151-6. PMID: 16214455.
      View in: PubMed
    34. Dember LM, Shepard JA, Nesta F, Stone JR. Case records of the Massachusetts General Hospital. Case 15-2005. An 80-year-old man with shortness of breath, edema, and proteinuria. N Engl J Med. 2005 May 19; 352(20):2111-9. PMID: 15901865.
      View in: PubMed
    35. Nesta F, Otsuji Y, Handschumacher MD, Messas E, Leavitt M, Carpentier A, Levine RA, Hung J. Leaflet concavity: a rapid visual clue to the presence and mechanism of functional mitral regurgitation. J Am Soc Echocardiogr. 2003 Dec; 16(12):1301-8. PMID: 14652610.
      View in: PubMed
    36. Freed LA, Acierno JS, Dai D, Leyne M, Marshall JE, Nesta F, Levine RA, Slaugenhaupt SA. A locus for autosomal dominant mitral valve prolapse on chromosome 11p15.4. Am J Hum Genet. 2003 Jun; 72(6):1551-9. PMID: 12707861; PMCID: PMC1180315.
      View in: PubMed, PubMed Central
    37. Mele D, Campana M, Sclavo M, Seveso G, Aschieri D, Nesta F, D'Aiello I, Ferrari R, Levine RA. Impact of tissue harmonic imaging in patients with distorted left ventricles: improvement in accuracy and reproducibility of visual, manual and automated echocardiographic assessment of left ventricular ejection fraction. Eur J Echocardiogr. 2003 Mar; 4(1):59-67. PMID: 12565064.
      View in: PubMed
    38. Mele D, Schwammenthal E, Torp H, Nesta F, Pedini I, Vandervoort P, Alboni P, Levine RA. A semiautomated objective technique for applying the proximal isovelocity surface area method to quantitate mitral regurgitation: Clinical studies with the digital flow map. Am Heart J. 2001 Apr; 141(4):653-60. PMID: 11275934.
      View in: PubMed
    39. Ferrari R, Agnoletti L, Ceconi C, Curello S, Nesta F, Manfredini R.Endothelial dysfunction during heart failure: effects of Carvedilol. Heart Failure Reviews. 1999; 1(4):53-64.
    40. Ferrari R, Pepi P, Ferrari F, Nesta F, Benigno M, Visioli O. Metabolic derangement in ischemic heart disease and its therapeutic control. Am J Cardiol. 1998 Sep 03; 82(5A):2K-13K. PMID: 9737480.
      View in: PubMed
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