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Grant Gullberg, PhD

Title(s)Professor, Radiology
SchoolSchool of Medicine
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    Collapse Research 
    Collapse Research Activities and Funding
    Dynamic cardiac SPECT
    NIH/NHLBI R01HL135490May 1, 2017 - Apr 30, 2021
    Role: Co-Principal Investigator
    Molecular Imaging of Cardiac Hypertrophy Using microPET and Pinhole SPECT
    NIH/NIBIB R01EB007219Jul 15, 2008 - Apr 30, 2013
    Role: Principal Investigator
    Dynamic Cardiac SPECT Imaging
    NIH/NHLBI R01HL050663Jan 1, 1995 - Apr 30, 2015
    Role: Principal Investigator
    FULLY THREE-DIMENSIONAL TOMOGRAPHY MEETING
    NIH/NCI R13CA059807May 15, 1993 - May 14, 1994
    Role: Principal Investigator
    Improved Cardiac SPECT-CT with Converging Hole Collimation
    NIH/NIBIB R01EB000121Jul 1, 1988 - May 31, 2013
    Role: Principal Investigator
    IMPROVED CARDIAC SPECT WITH CONVERGENT HOLE COLLIMATORS
    NIH/NHLBI R01HL039792Jul 1, 1988 - Mar 31, 2002
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Gullberg GT, Shrestha UM, Seo Y. PET imaging of glucose and fatty acid metabolism for NAFLD patients. J Nucl Cardiol. 2018 Dec 13. PMID: 30547298.
      View in: PubMed
    2. Gullberg GT, Fuller M, Shrestha U, Seo Y. Tensor Tomography of Dark Field Scatter using X-ray Interferometry with Bi-prisms. IEEE Nucl Sci Symp Conf Rec (1997). 2017 Oct; 2017. PMID: 30626995.
      View in: PubMed
    3. Mitra D, Abdalah M, Boutchko R, Chang H, Shrestha U, Botvinick E, Seo Y, Gullberg GT. Comparison of sparse domain approaches for 4D SPECT dynamic image reconstruction. Med Phys. 2018 Oct; 45(10):4493-4509. PMID: 30027577.
      View in: PubMed
    4. Gullberg GT, Shrestha UM, Seo Y. Dynamic cardiac PET imaging: Technological improvements advancing future cardiac health. J Nucl Cardiol. 2018 Jan 31. PMID: 29388118.
      View in: PubMed
    5. Pan H, Chang H, Mitra D, Gullberg GT, Seo Y. Sparse domain approaches in dynamic SPECT imaging with high-performance computing. Am J Nucl Med Mol Imaging. 2017; 7(6):283-294. PMID: 29348983.
      View in: PubMed
    6. Sciammarella M, Shrestha UM, Seo Y, Gullberg GT, Botvinick EH. A combined static-dynamic single-dose imaging protocol to compare quantitative dynamic SPECT with static conventional SPECT. J Nucl Cardiol. 2017 Aug 03. PMID: 28776314.
      View in: PubMed
    7. Zan Y, Long Y, Chen K, Li B, Huang Q, Gullberg GT. Design of a short nonuniform acquisition protocol for quantitative analysis in dynamic cardiac SPECT imaging - a retrospective 123 I-MIBG animal study. Med Phys. 2017 Jul; 44(7):3639-3649. PMID: 28429371.
      View in: PubMed
    8. Pampaloni MH, Shrestha UM, Sciammarella M, Seo Y, Gullberg GT, Botvinick EH. Noninvasive PET quantitative myocardial blood flow with regadenoson for assessing cardiac allograft vasculopathy in orthotopic heart transplantation patients. J Nucl Cardiol. 2017 08; 24(4):1134-1144. PMID: 28138813.
      View in: PubMed
    9. Huber JS, Hernandez AM, Janabi M, O'Neil JP, Brennan KM, Murphy ST, Seo Y, Gullberg GT. Longitudinal Evaluation of Myocardial Fatty Acid and Glucose Metabolism in Fasted and Nonfasted Spontaneously Hypertensive Rats Using MicroPET/CT. Mol Imaging. 2017 Jan-Dec; 16:1536012117724558. PMID: 28877656.
      View in: PubMed
    10. Tran N, Giannakidis A, Gullberg GT, Seo Y. Quantitative analysis of hypertrophic myocardium using diffusion tensor magnetic resonance imaging. J Med Imaging (Bellingham). 2016 Oct; 3(4):046001. PMID: 27872872.
      View in: PubMed
    11. Giannakidis A, Melkus G, Yang G, Gullberg GT. On the averaging of cardiac diffusion tensor MRI data: the effect of distance function selection. Phys Med Biol. 2016 11 07; 61(21):7765-7786. PMID: 27754986.
      View in: PubMed
    12. Giannakidis A, Gullberg GT, Pennell DJ, Firmin DN. Value of Formalin Fixation for the Prolonged Preservation of Rodent Myocardial Microanatomical Organization: Evidence by MR Diffusion Tensor Imaging. Anat Rec (Hoboken). 2016 07; 299(7):878-87. PMID: 27111575.
      View in: PubMed
    13. Shrestha U, Sciammarella M, Alhassen F, Yeghiazarians Y, Ellin J, Verdin E, Boyle A, Seo Y, Botvinick EH, Gullberg GT. Measurement of absolute myocardial blood flow in humans using dynamic cardiac SPECT and 99mTc-tetrofosmin: Method and validation. J Nucl Cardiol. 2017 02; 24(1):268-277. PMID: 26715603.
      View in: PubMed
    14. Shrestha UM, Seo Y, Botvinick EH, Gullberg GT. Image reconstruction in higher dimensions: myocardial perfusion imaging of tracer dynamics with cardiac motion due to deformation and respiration. Phys Med Biol. 2015 Nov 07; 60(21):8275-301. PMID: 26450115; PMCID: PMC4636034.
      View in: PubMed, PubMed Central
    15. Boutchko R, Mitra D, Baker SL, Jagust WJ, Gullberg GT. Clustering-initiated factor analysis application for tissue classification in dynamic brain positron emission tomography. J Cereb Blood Flow Metab. 2015 Jul; 35(7):1104-11. PMID: 25899294; PMCID: PMC4640278.
      View in: PubMed, PubMed Central
    16. Veress AI, Fung GS, Lee TS, Tsui BM, Kicska GA, Paul Segars W, Gullberg GT. The direct incorporation of perfusion defect information to define ischemia and infarction in a finite element model of the left ventricle. J Biomech Eng. 2015 May; 137(5):051004. PMID: 25367177; PMCID: PMC4340187.
      View in: PubMed, PubMed Central
    17. Zan Y, Boutchko R, Huang Q, Li B, Chen K, Gullberg GT. Longitudinal Evaluation of Sympathetic Nervous System and Perfusion in Normal and Spontaneously Hypertensive Rat Hearts with Dynamic Single-Photon Emission Computed Tomography. Mol Imaging. 2015; 14:373-84. PMID: 26162232.
      View in: PubMed
    18. Lee JH, Yao Y, Shrestha U, Gullberg GT, Seo Y. Handling Big Data in Medical Imaging: Iterative Reconstruction with Large-Scale Automated Parallel Computation. IEEE Nucl Sci Symp Conf Rec (1997). 2014 Nov; 2014. PMID: 27081299.
      View in: PubMed
    19. Shrestha U, Botvinick EH, Yeghiazarians Y, Seo Y, Gullberg GT. Quantitative Signature of Coronary Steal in a Patient with Occluded Coronary Arteries Supported by Collateral Circulation Using Dynamic SPECT. IEEE Nucl Sci Symp Conf Rec (1997). 2014 Nov; 2014. PMID: 27081301.
      View in: PubMed
    20. Lee TC, Ellin JR, Huang Q, Shrestha U, Gullberg GT, Seo Y. Multipinhole collimator with 20 apertures for a brain SPECT application. Med Phys. 2014 Nov; 41(11):112501. PMID: 25370660; PMCID: PMC4218691.
      View in: PubMed, PubMed Central
    21. Abdalah M, Boutchko R, Mitra D, Gullberg GT. Reconstruction of 4-D dynamic SPECT images from inconsistent projections using a Spline initialized FADS algorithm (SIFADS). IEEE Trans Med Imaging. 2015 Jan; 34(1):216-28. PMID: 25167546.
      View in: PubMed
    22. Lee TC, Burghardt AJ, Yao W, Lane NE, Majumdar S, Gullberg GT, Seo Y. Improved trabecular bone structure of 20-month-old male spontaneously hypertensive rats. Calcif Tissue Int. 2014 Sep; 95(3):282-91. PMID: 25106873; PMCID: PMC4153466.
      View in: PubMed, PubMed Central
    23. Wehrl HF, Wiehr S, Divine MR, Gatidis S, Gullberg GT, Maier FC, Rolle AM, Schwenck J, Thaiss WM, Pichler BJ. Preclinical and Translational PET/MR Imaging. J Nucl Med. 2014 Jun 01; 55(Supplement 2):11S-18S. PMID: 24833493.
      View in: PubMed
    24. Alhassen F, Nguyen N, Bains S, Gould RG, Seo Y, Bacharach SL, Song X, Shao L, Gullberg GT, Aparici CM. Myocardial blood flow measurement with a conventional dual-head SPECT/CT with spatiotemporal iterative reconstructions - a clinical feasibility study. Am J Nucl Med Mol Imaging. 2013; 4(1):53-9. PMID: 24380045; PMCID: PMC3867729.
      View in: PubMed, PubMed Central
    25. Hernandez AM, Huber JS, Murphy ST, Janabi M, Zeng GL, Brennan KM, O'Neil JP, Seo Y, Gullberg GT. Longitudinal evaluation of left ventricular substrate metabolism, perfusion, and dysfunction in the spontaneously hypertensive rat model of hypertrophy using small-animal PET/CT imaging. J Nucl Med. 2013 Nov; 54(11):1938-45. PMID: 24092939; PMCID: PMC4000452.
      View in: PubMed, PubMed Central
    26. Bowen JD, Huang Q, Ellin JR, Lee TC, Shrestha U, Gullberg GT, Seo Y. Design and performance evaluation of a 20-aperture multipinhole collimator for myocardial perfusion imaging applications. Phys Med Biol. 2013 Oct 21; 58(20):7209-26. PMID: 24061162; PMCID: PMC3855225.
      View in: PubMed, PubMed Central
    27. Zan Y, Boutchko R, Huang Q, Li B, Chen K, Gullberg GT. Fast direct estimation of the blood input function and myocardial time activity curve from dynamic SPECT projections via reduction in spatial and temporal dimensions. Med Phys. 2013 Sep; 40(9):092503. PMID: 24007179; PMCID: PMC3751963.
      View in: PubMed, PubMed Central
    28. Veress AI, Klein G, Gullberg GT. A Comparison of Hyperelastic Warping of PET Images with Tagged MRI for the Analysis of Cardiac Deformation. Int J Biomed Imaging. 2013; 2013:728624. PMID: 23843780; PMCID: PMC3697413.
      View in: PubMed, PubMed Central
    29. Zeng GL, Gullberg GT. On the bias of finite-view interior tomography using piecewise-constant and non-negativity constraints. Phys Med Biol. 2013 Mar 07; 58(5):L13-6. PMID: 23380877; PMCID: PMC3584581.
      View in: PubMed, PubMed Central
    30. Zeng GL, Kadrmas DJ, Gullberg GT. Fourier domain closed-form formulas for estimation of kinetic parameters in reversible multi-compartment models. Biomed Eng Online. 2012 Sep 20; 11:70. PMID: 22995548; PMCID: PMC3538570.
      View in: PubMed, PubMed Central
    31. Zeng GL, Hernandez A, Kadrmas DJ, Gullberg GT. Kinetic parameter estimation using a closed-form expression via integration by parts. Phys Med Biol. 2012 Sep 21; 57(18):5809-21. PMID: 22951326; PMCID: PMC3495573.
      View in: PubMed, PubMed Central
    32. Zeng GL, Gullberg GT. Null-space function estimation for the interior problem. Phys Med Biol. 2012 Apr 07; 57(7):1873-87. PMID: 22421269; PMCID: PMC3358924.
      View in: PubMed, PubMed Central
    33. Boutchko R, Rayz VL, Vandehey NT, O'Neil JP, Budinger TF, Nico PS, Druhan JL, Saloner DA, Gullberg GT, Moses WW. Imaging and modeling of flow in porous media using clinical nuclear emission tomography systems and computational fluid dynamics. J Appl Geophy. 2012 Jan; 76:74-81. PMID: 24917693.
      View in: PubMed
    34. Winant CD, Aparici CM, Zelnik YR, Reutter BW, Sitek A, Bacharach SL, Gullberg GT. Investigation of dynamic SPECT measurements of the arterial input function in human subjects using simulation, phantom and human studies. Phys Med Biol. 2012 Jan 21; 57(2):375-93. PMID: 22170801; PMCID: PMC3325151.
      View in: PubMed, PubMed Central
    35. Fung GS, Segars WP, Gullberg GT, Tsui BM. Development of a model of the coronary arterial tree for the 4D XCAT phantom. Phys Med Biol. 2011 Sep 07; 56(17):5651-63. PMID: 21828911; PMCID: PMC3169781.
      View in: PubMed, PubMed Central
    36. Lee KS, Roeck WW, Gullberg GT, Nalcioglu O. MR-based keyhole SPECT for small animal imaging. Phys Med Biol. 2011 Feb 07; 56(3):685-702. PMID: 21220840; PMCID: PMC3074940.
      View in: PubMed, PubMed Central
    37. Reutter BW, Huesman RH, Brennan KM, Boutchko R, Hanrahan SM, Gullberg GT. Longitudinal Evaluation of Fatty Acid Metabolism in Normal and Spontaneously Hypertensive Rat Hearts with Dynamic MicroSPECT Imaging. Int J Mol Imaging. 2011; 2011:893129. PMID: 21490736; PMCID: PMC3072139.
      View in: PubMed, PubMed Central
    38. Zeng GL, Gullberg GT, Kadrmas DJ. Closed-form kinetic parameter estimation solution to the truncated data problem. Phys Med Biol. 2010 Dec 21; 55(24):7453-68. PMID: 21098917; PMCID: PMC3023984.
      View in: PubMed, PubMed Central
    39. Veress AI, Segars WP, Tsui BM, Gullberg GT. Incorporation of a left ventricle finite element model defining infarction into the XCAT imaging phantom. IEEE Trans Med Imaging. 2011 Apr; 30(4):915-27. PMID: 21041157; PMCID: PMC3097415.
      View in: PubMed, PubMed Central
    40. Fung GS, Segars WP, Lee TS, Higuchi T, Veress AI, Gullberg GT, Tsui BM. Realistic Simulation of Regional Myocardial Perfusion Defects for Cardiac SPECT Studies. IEEE Nucl Sci Symp Conf Rec (1997). 2010 Oct-Nov; 2010:3061-3064. PMID: 26535552.
      View in: PubMed
    41. Gullberg GT, Reutter BW, Sitek A, Maltz JS, Budinger TF. Dynamic single photon emission computed tomography--basic principles and cardiac applications. Phys Med Biol. 2010 Oct 21; 55(20):R111-91. PMID: 20858925; PMCID: PMC3306016.
      View in: PubMed, PubMed Central
    42. Zeng GL, Gullberg GT. SPECT region of interest reconstruction with truncated transmission and emission data. Med Phys. 2010 Sep; 37(9):4627-33. PMID: 20964181; PMCID: PMC2933253.
      View in: PubMed, PubMed Central
    43. Zeng GL, Gullberg GT. Exact iterative reconstruction for the interior problem. Phys Med Biol. 2009 Oct 07; 54(19):5805-14. PMID: 19741279; PMCID: PMC3074952.
      View in: PubMed, PubMed Central
    44. Huang Q, Xu J, Tsui BM, Gullberg GT. Reconstructing uniformly attenuated rotating slant-hole SPECT projection data using the DBH method. Phys Med Biol. 2009 Jul 07; 54(13):4325-39. PMID: 19531850; PMCID: PMC2871256.
      View in: PubMed, PubMed Central
    45. Zeng GL, Gullberg GT. Exact emission SPECT reconstruction with truncated transmission data. Phys Med Biol. 2009 Jun 07; 54(11):3329-40. PMID: 19430109; PMCID: PMC2871257.
      View in: PubMed, PubMed Central
    46. Huang Q, You J, Zeng GL, Gullberg GT. Reconstruction from uniformly attenuated SPECT projection data using the DBH method. IEEE Trans Med Imaging. 2009 Jan; 28(1):17-29. PMID: 19116185; PMCID: PMC2871258.
      View in: PubMed, PubMed Central
    47. Veress AI, Weiss JA, Huesman RH, Reutter BW, Taylor SE, Sitek A, Feng B, Yang Y, Gullberg GT. Measuring regional changes in the diastolic deformation of the left ventricle of SHR rats using microPET technology and hyperelastic warping. Ann Biomed Eng. 2008 Jul; 36(7):1104-17. PMID: 18437574; PMCID: PMC2871255.
      View in: PubMed, PubMed Central
    48. Hwang AB, Franc BL, Gullberg GT, Hasegawa BH. Assessment of the sources of error affecting the quantitative accuracy of SPECT imaging in small animals. Phys Med Biol. 2008 May 07; 53(9):2233-52. PMID: 18401059; PMCID: PMC2871254.
      View in: PubMed, PubMed Central
    49. Rohmer D, Sitek A, Gullberg GT. Reconstruction and visualization of fiber and laminar structure in the normal human heart from ex vivo diffusion tensor magnetic resonance imaging (DTMRI) data. Invest Radiol. 2007 Nov; 42(11):777-89. PMID: 18030201.
      View in: PubMed
    50. Tang Q, Zeng GL, Gullberg GT. A Fourier reconstruction algorithm with constant attenuation compensation using 180 degrees acquisition data for SPECT. Phys Med Biol. 2007 Oct 21; 52(20):6165-79. PMID: 17921578.
      View in: PubMed
    51. Veress AI, Segars WP, Weiss JA, Tsui BM, Gullberg GT. Normal and pathological NCAT image and phantom data based on physiologically realistic left ventricle finite-element models. IEEE Trans Med Imaging. 2006 Dec; 25(12):1604-16. PMID: 17167995.
      View in: PubMed
    52. Sitek A, Huesman RH, Gullberg GT. Tomographic reconstruction using an adaptive tetrahedral mesh defined by a point cloud. IEEE Trans Med Imaging. 2006 Sep; 25(9):1172-9. PMID: 16967802.
      View in: PubMed
    53. Sitek A, Reutter BW, Huesman RH, Gullberg GT. Method of generating multiple sets of experimental phantom data. J Nucl Med. 2006 Jul; 47(7):1187-92. PMID: 16818954.
      View in: PubMed
    54. Defrise M, Gullberg GT. Image reconstruction. Phys Med Biol. 2006 Jul 07; 51(13):R139-54. PMID: 16790900.
      View in: PubMed
    55. Veress AI, Gullberg GT, Weiss JA. Measurement of strain in the left ventricle during diastole with cine-MRI and deformable image registration. J Biomech Eng. 2005 Dec; 127(7):1195-207. PMID: 16502662.
      View in: PubMed
    56. Tang Q, Zeng GL, Wu J, Gullberg GT. Exact fan-beam and 4pi-acquisition cone-beam SPECT algorithms with uniform attenuation correction. Med Phys. 2005 Nov; 32(11):3440-7. PMID: 16372416.
      View in: PubMed
    57. Tang Q, Zeng GL, Gullberg GT. Analytical fan-beam and cone-beam reconstruction algorithms with uniform attenuation correction for SPECT. Phys Med Biol. 2005 Jul 07; 50(13):3153-70. PMID: 15972987.
      View in: PubMed
    58. Zeng GL, Gullberg GT. Cone-beam and fan-beam image reconstruction algorithms based on spherical and circular harmonics. Phys Med Biol. 2004 Jun 07; 49(11):2239-56. PMID: 15248575.
      View in: PubMed
    59. Cheryauka AB, Lee JN, Samsonov AA, Defrise M, Gullberg GT. MRI diffusion tensor reconstruction with PROPELLER data acquisition. Magn Reson Imaging. 2004 Feb; 22(2):139-48. PMID: 15010105.
      View in: PubMed
    60. Veress AI, Weiss JA, Gullberg GT, Vince DG, Rabbitt RD. Strain measurement in coronary arteries using intravascular ultrasound and deformable images. J Biomech Eng. 2002 Dec; 124(6):734-41. PMID: 12596642.
      View in: PubMed
    61. Panin VY, Zeng GL, Defrise M, Gullberg GT. Diffusion tensor MR imaging of principal directions: a tensor tomography approach. Phys Med Biol. 2002 Aug 07; 47(15):2737-57. PMID: 12200936.
      View in: PubMed
    62. Feng B, Sitek A, Gullberg GT. Calculation of the left ventricular ejection fraction without edge detection: application to small hearts. J Nucl Med. 2002 Jun; 43(6):786-94. PMID: 12050324.
      View in: PubMed
    63. Sitek A, Gullberg GT, Huesman RH. Correction for ambiguous solutions in factor analysis using a penalized least squares objective. IEEE Trans Med Imaging. 2002 Mar; 21(3):216-25. PMID: 11989846.
      View in: PubMed
    64. Sitek A, Di Bella EV, Gullberg GT, Huesman RH. Removal of liver activity contamination in teboroxime dynamic cardiac SPECT imaging with the use of factor analysis. J Nucl Cardiol. 2002 Mar-Apr; 9(2):197-205. PMID: 11986565.
      View in: PubMed
    65. Khare HS, Dibella EV, Kadrmas DJ, Christian PE, Gullberg GT. Comparison of Static and Dynamic Cardiac Perfusion Thallium-201 SPECT. IEEE Trans Nucl Sci. 2001 Jun; 48(3):774. PMID: 20107525.
      View in: PubMed
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