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Jeffrey Bush, PhD

Title(s)Associate Professor, Cell and Tissue Biology
SchoolSchool of Dentistry
Address513 Parnassus Ave, HSE
San Francisco CA 94143
Phone415-476-9459
ORCID ORCID Icon0000-0002-6053-8756 Additional info
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    Phenotype-driven approach to understanding the function of craniofacial regulators using IMPC-generated mouse strains
    NIH/NIDCR R01DE028753Apr 1, 2019 - Mar 31, 2024
    Role: Co-Principal Investigator
    Mechanisms of early tracheal specification and morphogenesis
    NIH/NHLBI R01HL144785Mar 6, 2019 - Feb 28, 2023
    Role: Principal Investigator
    A human iPSC-based model of craniofrontonasal syndrome
    NIH/NIDCR R21DE025923Dec 1, 2016 - Nov 30, 2018
    Role: Principal Investigator
    Cellular mechanisms of lip and palate fusion
    NIH/NIDCR R01DE025877Apr 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    Delineating ephrin-B2 mechanisms in morphogenesis of the foregut
    NIH/NICHD R03HD084895Jul 5, 2015 - Jun 30, 2017
    Role: Principal Investigator
    Mechanisms of Eph/Ephrin signaling in craniofacial morphogenesis and craniofrontonasal syndrome
    NIH/NIDCR R01DE023337Jul 9, 2013 - May 31, 2023
    Role: Principal Investigator
    Nonmuscle myosins in craniofacial morphogenesis and orofacial clefting
    NIH/NIDCR R03DE022818Sep 1, 2012 - Aug 31, 2014
    Role: Principal Investigator
    Eph/ephrin signaling in craniofacial development and disease
    NIH/NIDCR R00DE020855Feb 1, 2011 - Jan 31, 2014
    Role: Principal Investigator
    Eph/ephrin signaling in craniofacial development and disease
    NIH/NIDCR K99DE020855Mar 1, 2010 - Jan 31, 2011
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Forced to communicate: Integration of mechanical and biochemical signaling in morphogenesis. Curr Opin Cell Biol. 2020 Jun 19; 66:59-68. Kindberg A, Hu JK, Bush JO. PMID: 32569947.
      View in: PubMed   Mentions:    Fields:    
    2. Delineating the early transcriptional specification of the mammalian trachea and esophagus. Elife. 2020 06 09; 9. Kuwahara A, Lewis AE, Coombes C, Leung FS, Percharde M, Bush JO. PMID: 32515350.
      View in: PubMed   Mentions:    Fields:    
    3. The UCSF Mouse Inventory Database Application, an Open Source Web App for Sharing Mutant Mice Within a Research Community. G3 (Bethesda). 2020 May 04; 10(5):1503-1510. Wall E, Scoles J, Joo A, Klein O, Quinonez C, Bush JO, Martin GR, Laird DJ. PMID: 32152007.
      View in: PubMed   Mentions:    Fields:    
    4. Aberrant cell segregation in the craniofacial primordium and the emergence of facial dysmorphology in craniofrontonasal syndrome. PLoS Genet. 2020 02; 16(2):e1008300. Niethamer TK, Teng T, Franco M, Du YX, Percival CJ, Bush JO. PMID: 32092051.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Cellular organization and boundary formation in craniofacial development. Genesis. 2019 01; 57(1):e23271. Kindberg AA, Bush JO. PMID: 30548771.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    6. WITHDRAWN: Editorial Introduction. Dev Biol. 2019 Jan 11. Bush JO, Andersson ER. PMID: 30639158.
      View in: PubMed   Mentions:    Fields:    
    7. Editorial: Signaling pathways instruct the blueprint of life. Dev Biol. 2019 03 01; 447(1):1-2. Bush JO, Andersson ER. PMID: 29885286.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. Getting direction(s): The Eph/ephrin signaling system in cell positioning. Dev Biol. 2019 03 01; 447(1):42-57. Niethamer TK, Bush JO. PMID: 29360434.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. Live Imaging of Mouse Secondary Palate Fusion. J Vis Exp. 2017 07 27; (125). Kim S, Prochazka J, Bush JO. PMID: 28784960.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    10. EPHRIN-B1 Mosaicism Drives Cell Segregation in Craniofrontonasal Syndrome hiPSC-Derived Neuroepithelial Cells. Stem Cell Reports. 2017 03 14; 8(3):529-537. Niethamer TK, Larson AR, O'Neill AK, Bershteyn M, Hsiao EC, Klein OD, Pomerantz JH, Bush JO. PMID: 28238796.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation. J Cell Biol. 2016 Oct 24; 215(2):217-229. O'Neill AK, Kindberg AA, Niethamer TK, Larson AR, Ho HH, Greenberg ME, Bush JO. PMID: 27810913.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    12. From Bench to Bedside and Back: Improving Diagnosis and Treatment of Craniofacial Malformations Utilizing Animal Models. Curr Top Dev Biol. 2015; 115:459-92. Goodwin AF, Kim R, Bush JO, Klein OD. PMID: 26589935.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    13. Neural crest defects in ephrin-B2 mutant mice are non-autonomous and originate from defects in the vasculature. Dev Biol. 2015 Oct 15; 406(2):186-95. Lewis AE, Hwa J, Wang R, Soriano P, Bush JO. PMID: 26385750.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    14. Convergence and extrusion are required for normal fusion of the mammalian secondary palate. PLoS Biol. 2015 Apr; 13(4):e1002122. Kim S, Lewis AE, Singh V, Ma X, Adelstein R, Bush JO. PMID: 25848986.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    15. Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate. Dev Dyn. 2014 Nov; 243(11):1470-6. Agrawal P, Wang M, Kim S, Lewis AE, Bush JO. PMID: 25073978.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    16. The society of craniofacial genetics and developmental biology 35th annual meeting. American Journal of Medical Genetics Part A. 2013 Dec 1; 161(12):2938-2952. Ophir D. Klein, Jeffrey O. Bush, Sarah M. Knox, Andrew H. Jheon, Dwight R. Cordero, Joan T. Richtsmeier. .
      View in: Publisher Site   Mentions:
    17. The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling. Dev Biol. 2013 Jul 15; 379(2):229-34. Lewis AE, Vasudevan HN, O'Neill AK, Soriano P, Bush JO. PMID: 23648512.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    18. Ephrin B1 maintains apical adhesion of neural progenitors. Development. 2013 May; 140(10):2082-92. Arvanitis DN, Béhar A, Tryoen-Tóth P, Bush JO, Jungas T, Vitale N, Davy A. PMID: 23578932.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    19. Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development. Development. 2012 Jan; 139(2):231-43. Bush JO, Jiang R. PMID: 22186724.
      View in: PubMed   Mentions: 119     Fields:    Translation:Animals
    20. Eph/ephrin signaling: genetic, phosphoproteomic, and transcriptomic approaches. Semin Cell Dev Biol. 2012 Feb; 23(1):26-34. Bush JO, Soriano P. PMID: 22040918.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    21. Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries. Genes Dev. 2010 Sep 15; 24(18):2068-80. Bush JO, Soriano P. PMID: 20844017.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    22. Analysis of signaling downstream of ephrin-B1 during development. Developmental Biology. 2009 Jul 1; 331(2):479. Jeffrey O. Bush, Philippe Soriano. .
      View in: Publisher Site   Mentions:
    23. Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism. Genes Dev. 2009 Jul 01; 23(13):1586-99. Bush JO, Soriano P. PMID: 19515977.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    24. The TGF-beta pseudoreceptor gene Bambi is dispensable for mouse embryonic development and postnatal survival. Genesis. 2007 Aug; 45(8):482-6. Chen J, Bush JO, Ovitt CE, Lan Y, Jiang R. PMID: 17661381.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    25. Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies craniofrontonasal syndrome. PLoS Biol. 2006 Oct; 4(10):e315. Davy A, Bush JO, Soriano P. PMID: 16968134.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    26. Development of the upper lip: morphogenetic and molecular mechanisms. Dev Dyn. 2006 May; 235(5):1152-66. Jiang R, Bush JO, Lidral AC. PMID: 16292776.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    27. Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice. Dev Dyn. 2006 May; 235(5):1448-54. Lan Y, Ryan RC, Zhang Z, Bullard SA, Bush JO, Maltby KM, Lidral AC, Jiang R. PMID: 16496313.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    28. Development of the upper lip: Morphogenetic and molecular mechanisms. Developmental Dynamics. 2006 May 1; 235(5):spc1-spc1. Rulang Jiang, Jeffrey O. Bush, Andrew C. Lidral. .
      View in: Publisher Site   Mentions:
    29. The cleft lip and palate defects in Dancer mutant mice result from gain of function of the Tbx10 gene. Proc Natl Acad Sci U S A. 2004 May 04; 101(18):7022-7. Bush JO, Lan Y, Jiang R. PMID: 15118109.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    30. The T-box gene Tbx10 exhibits a uniquely restricted expression pattern during mouse embryogenesis. Gene Expr Patterns. 2003 Aug; 3(4):533-8. Bush JO, Maltby KM, Cho ES, Jiang R. PMID: 12915323.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    31. Isolation and developmental expression analysis of Tbx22, the mouse homolog of the human X-linked cleft palate gene. Dev Dyn. 2002 Nov; 225(3):322-6. Bush JO, Lan Y, Maltby KM, Jiang R. PMID: 12412015.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
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