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Jeffrey Bush, PhD

Title(s)Associate Professor, Cell and Tissue Biology
SchoolSchool of Dentistry
Phone415-476-9459
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    Phenotype-driven approach to understanding the function of craniofacial regulators using IMPC-generated mouse strains
    NIH/NIDCR R01DE028753Apr 1, 2019 - Mar 31, 2024
    Role: Co-Principal Investigator
    Mechanisms of early tracheal specification and morphogenesis
    NIH/NHLBI R01HL144785Mar 6, 2019 - Feb 28, 2023
    Role: Principal Investigator
    A human iPSC-based model of craniofrontonasal syndrome
    NIH/NIDCR R21DE025923Dec 1, 2016 - Nov 30, 2018
    Role: Principal Investigator
    Cellular mechanisms of lip and palate fusion
    NIH/NIDCR R01DE025877Apr 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    Delineating ephrin-B2 mechanisms in morphogenesis of the foregut
    NIH/NICHD R03HD084895Jul 5, 2015 - Jun 30, 2017
    Role: Principal Investigator
    Mechanisms of Eph/Ephrin signaling in craniofacial morphogenesis and craniofrontonasal syndrome
    NIH/NIDCR R01DE023337Jul 9, 2013 - May 31, 2023
    Role: Principal Investigator
    Nonmuscle myosins in craniofacial morphogenesis and orofacial clefting
    NIH/NIDCR R03DE022818Sep 1, 2012 - Aug 31, 2014
    Role: Principal Investigator
    Eph/ephrin signaling in craniofacial development and disease
    NIH/NIDCR R00DE020855Feb 1, 2011 - Jan 31, 2014
    Role: Principal Investigator
    Eph/ephrin signaling in craniofacial development and disease
    NIH/NIDCR K99DE020855Mar 1, 2010 - Jan 31, 2011
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kindberg AA, Bush JO. Cellular organization and boundary formation in craniofacial development. Genesis. 2019 01; 57(1):e23271. PMID: 30548771.
      View in: PubMed
    2. Bush JO, Andersson ER. WITHDRAWN: Editorial Introduction. Dev Biol. 2019 Jan 11. PMID: 30639158.
      View in: PubMed
    3. Bush JO, Andersson ER. Editorial: Signaling pathways instruct the blueprint of life. Dev Biol. 2019 Mar 01; 447(1):1-2. PMID: 29885286.
      View in: PubMed
    4. Niethamer TK, Bush JO. Getting direction(s): The Eph/ephrin signaling system in cell positioning. Dev Biol. 2019 Mar 01; 447(1):42-57. PMID: 29360434.
      View in: PubMed
    5. Kim S, Prochazka J, Bush JO. Live Imaging of Mouse Secondary Palate Fusion. J Vis Exp. 2017 07 27; (125). PMID: 28784960.
      View in: PubMed
    6. Niethamer TK, Larson AR, O'Neill AK, Bershteyn M, Hsiao EC, Klein OD, Pomerantz JH, Bush JO. EPHRIN-B1 Mosaicism Drives Cell Segregation in Craniofrontonasal Syndrome hiPSC-Derived Neuroepithelial Cells. Stem Cell Reports. 2017 03 14; 8(3):529-537. PMID: 28238796.
      View in: PubMed
    7. O'Neill AK, Kindberg AA, Niethamer TK, Larson AR, Ho HH, Greenberg ME, Bush JO. Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation. J Cell Biol. 2016 Oct 24; 215(2):217-229. PMID: 27810913.
      View in: PubMed
    8. Goodwin AF, Kim R, Bush JO, Klein OD. From Bench to Bedside and Back: Improving Diagnosis and Treatment of Craniofacial Malformations Utilizing Animal Models. Curr Top Dev Biol. 2015; 115:459-92. PMID: 26589935.
      View in: PubMed
    9. Lewis AE, Hwa J, Wang R, Soriano P, Bush JO. Neural crest defects in ephrin-B2 mutant mice are non-autonomous and originate from defects in the vasculature. Dev Biol. 2015 Oct 15; 406(2):186-95. PMID: 26385750; PMCID: PMC4639416 [Available on 10/15/16].
      View in: PubMed, PubMed Central
    10. Kim S, Lewis AE, Singh V, Ma X, Adelstein R, Bush JO. Convergence and extrusion are required for normal fusion of the mammalian secondary palate. PLoS Biol. 2015 Apr; 13(4):e1002122. PMID: 25848986.
      View in: PubMed
    11. Agrawal P, Wang M, Kim S, Lewis AE, Bush JO. Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate. Dev Dyn. 2014 Nov; 243(11):1470-6. PMID: 25073978; PMCID: PMC4404412.
      View in: PubMed, PubMed Central
    12. Lewis AE, Vasudevan HN, O'Neill AK, Soriano P, Bush JO. The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling. Dev Biol. 2013 Jul 15; 379(2):229-34. PMID: 23648512.
      View in: PubMed
    13. Arvanitis DN, Béhar A, Tryoen-Tóth P, Bush JO, Jungas T, Vitale N, Davy A. Ephrin B1 maintains apical adhesion of neural progenitors. Development. 2013 May; 140(10):2082-92. PMID: 23578932.
      View in: PubMed
    14. Bush JO, Jiang R. Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development. Development. 2012 Jan; 139(2):231-43. PMID: 22186724; PMCID: PMC3243091.
      View in: PubMed, PubMed Central
    15. Bush JO, Soriano P. Eph/ephrin signaling: genetic, phosphoproteomic, and transcriptomic approaches. Semin Cell Dev Biol. 2012 Feb; 23(1):26-34. PMID: 22040918; PMCID: PMC3288612.
      View in: PubMed, PubMed Central
    16. Bush JO, Soriano P. Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries. Genes Dev. 2010 Sep 15; 24(18):2068-80. PMID: 20844017.
      View in: PubMed
    17. Bush JO, Soriano P. Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism. Genes Dev. 2009 Jul 01; 23(13):1586-99. PMID: 19515977.
      View in: PubMed
    18. Chen J, Bush JO, Ovitt CE, Lan Y, Jiang R. The TGF-beta pseudoreceptor gene Bambi is dispensable for mouse embryonic development and postnatal survival. Genesis. 2007 Aug; 45(8):482-6. PMID: 17661381; PMCID: PMC2376806.
      View in: PubMed, PubMed Central
    19. Davy A, Bush JO, Soriano P. Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies craniofrontonasal syndrome. PLoS Biol. 2006 Oct; 4(10):e315. PMID: 16968134; PMCID: PMC1563491.
      View in: PubMed, PubMed Central
    20. Lan Y, Ryan RC, Zhang Z, Bullard SA, Bush JO, Maltby KM, Lidral AC, Jiang R. Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice. Dev Dyn. 2006 May; 235(5):1448-54. PMID: 16496313; PMCID: PMC2559872.
      View in: PubMed, PubMed Central
    21. Jiang R, Bush JO, Lidral AC. Development of the upper lip: morphogenetic and molecular mechanisms. Dev Dyn. 2006 May; 235(5):1152-66. PMID: 16292776; PMCID: PMC2562450.
      View in: PubMed, PubMed Central
    22. Bush JO, Lan Y, Jiang R. The cleft lip and palate defects in Dancer mutant mice result from gain of function of the Tbx10 gene. Proc Natl Acad Sci U S A. 2004 May 04; 101(18):7022-7. PMID: 15118109; PMCID: PMC406459.
      View in: PubMed, PubMed Central
    23. Bush JO, Maltby KM, Cho ES, Jiang R. The T-box gene Tbx10 exhibits a uniquely restricted expression pattern during mouse embryogenesis. Gene Expr Patterns. 2003 Aug; 3(4):533-8. PMID: 12915323.
      View in: PubMed
    24. Bush JO, Lan Y, Maltby KM, Jiang R. Isolation and developmental expression analysis of Tbx22, the mouse homolog of the human X-linked cleft palate gene. Dev Dyn. 2002 Nov; 225(3):322-6. PMID: 12412015.
      View in: PubMed
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