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Jeffrey Bush, PhD

TitleAssociate Professor
SchoolUCSF School of Dentistry
DepartmentCell and Tissue Biology
AddressCore Campus, HSE
San Francisco CA 94143
Phone415-476-9459
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    Collapse Research 
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    A human iPSC-based model of craniofrontonasal syndrome
    NIH/NIDCR R21DE025923Dec 1, 2016 - Nov 30, 2018
    Role: Principal Investigator
    Cellular mechanisms of lip and palate fusion
    NIH/NIDCR R01DE025877Apr 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    Delineating ephrin-B2 mechanisms in morphogenesis of the foregut
    NIH/NICHD R03HD084895Jul 5, 2015 - Jun 30, 2017
    Role: Principal Investigator
    Mechanisms of craniofrontonasal syndrome: toward a rational therapeutic strategy
    NIH/NIDCR R01DE023337Jul 9, 2013 - May 31, 2018
    Role: Principal Investigator
    Nonmuscle myosins in craniofacial morphogenesis and orofacial clefting
    NIH/NIDCR R03DE022818Sep 1, 2012 - Aug 31, 2014
    Role: Principal Investigator
    Eph/ephrin signaling in craniofacial development and disease
    NIH/NIDCR R00DE020855Feb 1, 2011 - Jan 31, 2014
    Role: Principal Investigator
    Eph/ephrin signaling in craniofacial development and disease
    NIH/NIDCR K99DE020855Mar 1, 2010 - Jan 31, 2011
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Niethamer TK, Larson AR, O'Neill AK, Bershteyn M, Hsiao EC, Klein OD, Pomerantz JH, Bush J. EPHRIN-B1 Mosaicism Drives Cell Segregation in Craniofrontonasal Syndrome hiPSC-Derived Neuroepithelial Cells. Stem Cell Reports. 2017 Feb 22. PMID: 28238796.
      View in: PubMed
    2. O'Neill AK, Kindberg AA, Niethamer TK, Larson AR, Ho HH, Greenberg ME, Bush J. Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation. J Cell Biol. 2016 Oct 24; 215(2):217-229. PMID: 27810913.
      View in: PubMed
    3. Goodwin AF, Kim R, Bush J, Klein OD. From Bench to Bedside and Back: Improving Diagnosis and Treatment of Craniofacial Malformations Utilizing Animal Models. Curr Top Dev Biol. 2015; 115:459-92. PMID: 26589935.
      View in: PubMed
    4. Lewis AE, Hwa J, Wang R, Soriano P, Bush J. Neural crest defects in ephrin-B2 mutant mice are non-autonomous and originate from defects in the vasculature. Dev Biol. 2015 Oct 15; 406(2):186-95. PMID: 26385750; PMCID: PMC4639416 [Available on 10/15/16].
      View in: PubMed, PubMed Central
    5. Kim S, Lewis AE, Singh V, Ma X, Adelstein R, Bush J. Convergence and extrusion are required for normal fusion of the mammalian secondary palate. PLoS Biol. 2015 Apr; 13(4):e1002122. PMID: 25848986; PMCID: PMC4388528.
      View in: PubMed, PubMed Central
    6. Agrawal P, Wang M, Kim S, Lewis AE, Bush J. Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate. Dev Dyn. 2014 Nov; 243(11):1470-6. PMID: 25073978; PMCID: PMC4404412.
      View in: PubMed, PubMed Central
    7. Lewis AE, Vasudevan HN, O'Neill AK, Soriano P, Bush J. The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling. Dev Biol. 2013 Jul 15; 379(2):229-34. PMID: 23648512; PMCID: PMC3804302.
      View in: PubMed, PubMed Central
    8. Arvanitis DN, Béhar A, Tryoen-Tóth P, Bush J, Jungas T, Vitale N, Davy A. Ephrin B1 maintains apical adhesion of neural progenitors. Development. 2013 May; 140(10):2082-92. PMID: 23578932.
      View in: PubMed
    9. Bush J, Jiang R. Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development. Development. 2012 Jan; 139(2):231-43. PMID: 22186724; PMCID: PMC3243091.
      View in: PubMed, PubMed Central
    10. Bush J, Soriano P. Eph/ephrin signaling: genetic, phosphoproteomic, and transcriptomic approaches. Semin Cell Dev Biol. 2012 Feb; 23(1):26-34. PMID: 22040918; PMCID: PMC3288612.
      View in: PubMed, PubMed Central
    11. Bush J, Soriano P. Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries. Genes Dev. 2010 Sep 15; 24(18):2068-80. PMID: 20844017; PMCID: PMC2939368.
      View in: PubMed, PubMed Central
    12. Bush J, Soriano P. Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism. Genes Dev. 2009 Jul 1; 23(13):1586-99. PMID: 19515977; PMCID: PMC2704468.
      View in: PubMed, PubMed Central
    13. Chen J, Bush J, Ovitt CE, Lan Y, Jiang R. The TGF-beta pseudoreceptor gene Bambi is dispensable for mouse embryonic development and postnatal survival. Genesis. 2007 Aug; 45(8):482-6. PMID: 17661381; PMCID: PMC2376806.
      View in: PubMed, PubMed Central
    14. Davy A, Bush J, Soriano P. Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies craniofrontonasal syndrome. PLoS Biol. 2006 Oct; 4(10):e315. PMID: 16968134; PMCID: PMC1563491.
      View in: PubMed, PubMed Central
    15. Jiang R, Bush J, Lidral AC. Development of the upper lip: morphogenetic and molecular mechanisms. Dev Dyn. 2006 May; 235(5):1152-66. PMID: 16292776; PMCID: PMC2562450.
      View in: PubMed, PubMed Central
    16. Lan Y, Ryan RC, Zhang Z, Bullard SA, Bush J, Maltby KM, Lidral AC, Jiang R. Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice. Dev Dyn. 2006 May; 235(5):1448-54. PMID: 16496313; PMCID: PMC2559872.
      View in: PubMed, PubMed Central
    17. Bush J, Lan Y, Jiang R. The cleft lip and palate defects in Dancer mutant mice result from gain of function of the Tbx10 gene. Proc Natl Acad Sci U S A. 2004 May 4; 101(18):7022-7. PMID: 15118109; PMCID: PMC406459.
      View in: PubMed, PubMed Central
    18. Bush J, Maltby KM, Cho ES, Jiang R. The T-box gene Tbx10 exhibits a uniquely restricted expression pattern during mouse embryogenesis. Gene Expr Patterns. 2003 Aug; 3(4):533-8. PMID: 12915323.
      View in: PubMed
    19. Bush J, Lan Y, Maltby KM, Jiang R. Isolation and developmental expression analysis of Tbx22, the mouse homolog of the human X-linked cleft palate gene. Dev Dyn. 2002 Nov; 225(3):322-6. PMID: 12412015.
      View in: PubMed
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