Jeffrey Bush • UCSF Profiles

Jeffrey Bush, PhD

Title(s)	Associate Professor, Cell And Tissue Biology
School	School of Dentistry
Phone	415-476-9459
ORCID	0000-0002-6053-8756
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Research

Research Activities and Funding

Phenotype-driven approach to understanding the function of craniofacial regulators using IMPC-generated mouse strains
NIH/NIDCR R01DE028753Apr 1, 2019 - Mar 31, 2024
Role: Co-Principal Investigator

Mechanisms of early tracheal specification and morphogenesis
NIH/NHLBI R01HL144785Mar 6, 2019 - Feb 28, 2023
Role: Principal Investigator

A human iPSC-based model of craniofrontonasal syndrome
NIH/NIDCR R21DE025923Dec 1, 2016 - Nov 30, 2018
Role: Principal Investigator

Cellular mechanisms of lip and palate fusion
NIH/NIDCR R01DE025877Apr 1, 2016 - Mar 31, 2021
Role: Principal Investigator

Delineating ephrin-B2 mechanisms in morphogenesis of the foregut
NIH/NICHD R03HD084895Jul 5, 2015 - Jun 30, 2017
Role: Principal Investigator

Mechanisms of Eph/Ephrin signaling in craniofacial morphogenesis and craniofrontonasal syndrome
NIH/NIDCR R01DE023337Jul 9, 2013 - May 31, 2023
Role: Principal Investigator

Nonmuscle myosins in craniofacial morphogenesis and orofacial clefting
NIH/NIDCR R03DE022818Sep 1, 2012 - Aug 31, 2014
Role: Principal Investigator

Eph/ephrin signaling in craniofacial development and disease
NIH/NIDCR R00DE020855Feb 1, 2011 - Jan 31, 2014
Role: Principal Investigator

Eph/ephrin signaling in craniofacial development and disease
NIH/NIDCR K99DE020855Mar 1, 2010 - Jan 31, 2011
Role: Principal Investigator

ORNG Applications

Featured Videos

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.

List All | Timeline

Wall E, Scoles J, Joo A, Klein O, Quinonez C, Bush JO, Martin GR, Laird DJ. The UCSF Mouse Inventory Database Application, an Open Source Web App for Sharing Mutant Mice within a Research Community. G3 (Bethesda). 2020 Mar 09. PMID: 32152007.

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Niethamer TK, Teng T, Franco M, Du YX, Percival CJ, Bush JO. Aberrant cell segregation in the craniofacial primordium and the emergence of facial dysmorphology in craniofrontonasal syndrome. PLoS Genet. 2020 Feb; 16(2):e1008300. PMID: 32092051.

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Kindberg AA, Bush JO. Cellular organization and boundary formation in craniofacial development. Genesis. 2019 01; 57(1):e23271. PMID: 30548771.

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Bush JO, Andersson ER. WITHDRAWN: Editorial Introduction. Dev Biol. 2019 Jan 11. PMID: 30639158.

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Bush JO, Andersson ER. Editorial: Signaling pathways instruct the blueprint of life. Dev Biol. 2019 03 01; 447(1):1-2. PMID: 29885286.

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Niethamer TK, Bush JO. Getting direction(s): The Eph/ephrin signaling system in cell positioning. Dev Biol. 2019 03 01; 447(1):42-57. PMID: 29360434.

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Kim S, Prochazka J, Bush JO. Live Imaging of Mouse Secondary Palate Fusion. J Vis Exp. 2017 07 27; (125). PMID: 28784960.

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Niethamer TK, Larson AR, O'Neill AK, Bershteyn M, Hsiao EC, Klein OD, Pomerantz JH, Bush JO. EPHRIN-B1 Mosaicism Drives Cell Segregation in Craniofrontonasal Syndrome hiPSC-Derived Neuroepithelial Cells. Stem Cell Reports. 2017 03 14; 8(3):529-537. PMID: 28238796.

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O'Neill AK, Kindberg AA, Niethamer TK, Larson AR, Ho HH, Greenberg ME, Bush JO. Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation. J Cell Biol. 2016 Oct 24; 215(2):217-229. PMID: 27810913.

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Goodwin AF, Kim R, Bush JO, Klein OD. From Bench to Bedside and Back: Improving Diagnosis and Treatment of Craniofacial Malformations Utilizing Animal Models. Curr Top Dev Biol. 2015; 115:459-92. PMID: 26589935.

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Lewis AE, Hwa J, Wang R, Soriano P, Bush JO. Neural crest defects in ephrin-B2 mutant mice are non-autonomous and originate from defects in the vasculature. Dev Biol. 2015 Oct 15; 406(2):186-95. PMID: 26385750.

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Kim S, Lewis AE, Singh V, Ma X, Adelstein R, Bush JO. Convergence and extrusion are required for normal fusion of the mammalian secondary palate. PLoS Biol. 2015 Apr; 13(4):e1002122. PMID: 25848986.

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Agrawal P, Wang M, Kim S, Lewis AE, Bush JO. Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate. Dev Dyn. 2014 Nov; 243(11):1470-6. PMID: 25073978.

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Ophir D. Klein, Jeffrey O. Bush, Sarah M. Knox, Andrew H. Jheon, Dwight R. Cordero, Joan T. Richtsmeier. The society of craniofacial genetics and developmental biology 35th annual meeting. American Journal of Medical Genetics Part A. 2013 Dec 1; 161(12):2938-2952.

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Lewis AE, Vasudevan HN, O'Neill AK, Soriano P, Bush JO. The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling. Dev Biol. 2013 Jul 15; 379(2):229-34. PMID: 23648512.

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Arvanitis DN, Béhar A, Tryoen-Tóth P, Bush JO, Jungas T, Vitale N, Davy A. Ephrin B1 maintains apical adhesion of neural progenitors. Development. 2013 May; 140(10):2082-92. PMID: 23578932.

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Bush JO, Jiang R. Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development. Development. 2012 Jan; 139(2):231-43. PMID: 22186724.

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Bush JO, Soriano P. Eph/ephrin signaling: genetic, phosphoproteomic, and transcriptomic approaches. Semin Cell Dev Biol. 2012 Feb; 23(1):26-34. PMID: 22040918.

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Bush JO, Soriano P. Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries. Genes Dev. 2010 Sep 15; 24(18):2068-80. PMID: 20844017.

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Jeffrey O. Bush, Philippe Soriano. Analysis of signaling downstream of ephrin-B1 during development. Developmental Biology. 2009 Jul 1; 331(2):479.

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Bush JO, Soriano P. Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism. Genes Dev. 2009 Jul 01; 23(13):1586-99. PMID: 19515977.

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Chen J, Bush JO, Ovitt CE, Lan Y, Jiang R. The TGF-beta pseudoreceptor gene Bambi is dispensable for mouse embryonic development and postnatal survival. Genesis. 2007 Aug; 45(8):482-6. PMID: 17661381.

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Davy A, Bush JO, Soriano P. Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies craniofrontonasal syndrome. PLoS Biol. 2006 Oct; 4(10):e315. PMID: 16968134.

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Jiang R, Bush JO, Lidral AC. Development of the upper lip: morphogenetic and molecular mechanisms. Dev Dyn. 2006 May; 235(5):1152-66. PMID: 16292776.

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Lan Y, Ryan RC, Zhang Z, Bullard SA, Bush JO, Maltby KM, Lidral AC, Jiang R. Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice. Dev Dyn. 2006 May; 235(5):1448-54. PMID: 16496313.

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Rulang Jiang, Jeffrey O. Bush, Andrew C. Lidral. Development of the upper lip: Morphogenetic and molecular mechanisms. Developmental Dynamics. 2006 May 1; 235(5):spc1-spc1.

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Bush JO, Lan Y, Jiang R. The cleft lip and palate defects in Dancer mutant mice result from gain of function of the Tbx10 gene. Proc Natl Acad Sci U S A. 2004 May 04; 101(18):7022-7. PMID: 15118109.

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Bush JO, Maltby KM, Cho ES, Jiang R. The T-box gene Tbx10 exhibits a uniquely restricted expression pattern during mouse embryogenesis. Gene Expr Patterns. 2003 Aug; 3(4):533-8. PMID: 12915323.

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Bush JO, Lan Y, Maltby KM, Jiang R. Isolation and developmental expression analysis of Tbx22, the mouse homolog of the human X-linked cleft palate gene. Dev Dyn. 2002 Nov; 225(3):322-6. PMID: 12412015.

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