Jeffrey Bush, PhD

Title(s)Professor, Cell and Tissue Biology
SchoolSchool of Dentistry
Address513 Parnassus Avenue, HSE, #1502
San Francisco CA 94143
ORCID ORCID Icon0000-0002-6053-8756 Additional info
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    Rutgers University, New Brunswick, NJBA05/1999Molecular Biology and Biochemistry
    University of Rochester, Rochester, NYMS/Ph.D.2004Biology/Developmental Genetics
    Fred Hutchinson Cancer Research Center and Mt. Sinai School of Medicine, Seattle/New York CityPostdoctoral2011Cell signaling and morphogenesis

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    As a Professor and Chair of the Department of Cell and Tissue Biology at UCSF, I study fundamental mechanisms by which signaling between cells coordinates mammalian morphogenesis. These studies have significance to understanding and ultimately informing therapies for human congenital anomalies, which are the leading cause of death for infants during the first year of life. Our lab has NIH-sponsored projects focused on understanding development in multiple organ systems that include the craniofacial complex, the brain, the trachea and the esophagus. We have a highly collaborative group of researchers that are committed to understanding fundamental cellular and genetic mechanisms that underlie development and disease. We have made discoveries that reveal the intricate mechanisms of EPH/EPHRIN signaling during development, have elucidated how tissue fusion occurs in multiple aspects of development, and have revealed early transcriptional networks that control tracheal development. To make these discoveries, we have developed new live imaging approaches, novel mouse genetics reagents, and the first human induced pluripotent stem cell model of a congenital craniofacial disease.
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    Signaling control and cellular basis of craniofacial morphogenesis and congenital disease
    NIH/NIDCR R35DE031926Mar 1, 2022 - Feb 28, 2030
    Role: PI
    Description: This is an R35 NIH/NIDCR Award for Sustaining Outstanding Achievement in Research (SOAR) application. This proposal seeks to study cellular mechanisms driving craniofacial morphogenesis. This work includes a focus on signaling molecules that regulate mesenchymal cell movements, studies on understanding the cellular dynamics of craniofacial tissue fusion, and the generation and study of new mouse models of craniofacial congenital disease.
    Phenotype-driven approach to understanding the function of craniofacial regulators using IMPC-generated mouse strains
    NIH R01DE028753Apr 1, 2019 - Mar 31, 2024
    Role: Co-Principal Investigator
    Mechanisms of early tracheal specification and morphogenesis
    NIH R01HL144785Mar 6, 2019 - Feb 28, 2023
    Role: Principal Investigator
    A human iPSC-based model of craniofrontonasal syndrome
    NIH R21DE025923Dec 1, 2016 - Nov 30, 2019
    Role: Principal Investigator
    Cellular mechanisms of lip and palate fusion
    NIH R01DE025877Apr 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    Delineating ephrin-B2 mechanisms in morphogenesis of the foregut
    NIH R03HD084895Jul 5, 2015 - Jun 30, 2017
    Role: Principal Investigator
    Mechanisms of Eph/Ephrin signaling in craniofacial morphogenesis and craniofrontonasal syndrome
    NIH R01DE023337Jul 9, 2013 - May 31, 2023
    Role: Principal Investigator
    Nonmuscle myosins in craniofacial morphogenesis and orofacial clefting
    NIH R03DE022818Sep 1, 2012 - Aug 31, 2014
    Role: Principal Investigator
    Eph/ephrin signaling in craniofacial development and disease
    NIH R00DE020855Feb 1, 2011 - Jan 31, 2014
    Role: Principal Investigator
    Eph/ephrin signaling in craniofacial development and disease
    NIH K99DE020855Mar 1, 2010 - Jan 31, 2011
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Eed controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crest. bioRxiv. 2024 Mar 14. Casey-Clyde T, Liu SJ, Serrano JAC, Teng C, Jang YG, Vasudevan HN, Bush JO, Raleigh DR. PMID: 38558995; PMCID: PMC10979956.
      View in: PubMed   Mentions:
    2. Alternative cleavage and polyadenylation of the Ccnb1 mRNA defines accumulation of cyclin protein during the meiotic cell cycle. Nucleic Acids Res. 2024 Feb 09; 52(3):1258-1271. Wang X, Leung FS, Bush JO, Conti M. PMID: 38048302; PMCID: PMC10853788.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. A Suite of Mouse Reagents for Studying Amelogenesis. bioRxiv. 2023 Apr 02. Wald T, Verma A, Cooley V, Marangoni P, Cazares O, Sharir A, Sandoval EJ, Sung D, Najibi H, Drennon TY, Bush JO, Joester D, Klein OD. PMID: 37034814; PMCID: PMC10081212.
      View in: PubMed   Mentions:
    4. Exome sequencing efficacy and phenotypic expansions involving esophageal atresia/tracheoesophageal fistula plus. Am J Med Genet A. 2022 12; 188(12):3492-3504. Sy MR, Chauhan J, Prescott K, Imam A, Kraus A, Beleza A, Salkeld L, Hosdurga S, Parker M, Vasudevan P, Islam L, Goel H, Bain N, Park SM, Mohammed S, Dieterich K, Coutton C, Satre V, Vieville G, Donaldson A, Beneteau C, Ghoumid J, Van Den Bogaert K, Boogaerts A, Boudry E, Vanlerberghe C, Petit F, Bernardini L, Torres B, Mattina T, Carli D, Mandrile G, Pinelli M, Brunetti-Pierri N, Neas K, Beddow R, Tørring PM, Faletra F, Spedicati B, Gasparini P, Mussa A, Ferrero GB, Lampe A, Lam W, Bi W, Bacino CA, Kuwahara A, Bush JO, Zhao X, Luna PN, Shaw CA, Rosenfeld JA, Scott DA. PMID: 36135330; PMCID: PMC9669235.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. A unique form of collective epithelial migration is crucial for tissue fusion in the secondary palate and can overcome loss of epithelial apoptosis. Development. 2022 05 15; 149(10). Teng T, Teng CS, Kaartinen V, Bush JO. PMID: 35593401; PMCID: PMC9188751.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    6. Investigating Cell Fate Specification upon Nkx2-1Loss. The FASEB Journal. 2022 May 13; 36(S1). O'Neill OM, Bush BJ. .
      View in: Publisher Site   Mentions:
    7. Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sorting. Cell Rep. 2022 03 15; 38(11):110510. Lewis AE, Kuwahara A, Franzosi J, Bush JO. PMID: 35294885; PMCID: PMC9033272.
      View in: PubMed   Mentions: 2     Fields:    
    8. Cellular and molecular mechanisms of EPH/EPHRIN signaling in evolution and development. Curr Top Dev Biol. 2022; 149:153-201. Bush JO. PMID: 35606056.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    9. Investigating the effects of compound paralogous EPHB receptor mutations on mouse facial development. Dev Dyn. 2022 07; 251(7):1138-1155. Mincer ST, Niethamer TK, Teng T, Bush JO, Percival CJ. PMID: 35025117; PMCID: PMC9924224.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    10. EPH/EPHRIN regulates cellular organization by actomyosin contractility effects on cell contacts. J Cell Biol. 2021 06 07; 220(6). Kindberg AA, Srivastava V, Muncie JM, Weaver VM, Gartner ZJ, Bush JO. PMID: 33798261; PMCID: PMC8025214.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    11. Separation of the trachea and esophagus is coupled to identity specification by NKX2-1-mediated regulation of EPH/EPHRIN signaling and cell sorting. The FASEB Journal. 2021 May 14; 35(S1). Lewis LA, Kuwahara KA, Bush BJ. .
      View in: Publisher Site   Mentions:
    12. Cellular and Molecular Regulation of Upper Lip Fusion. The FASEB Journal. 2021 May 14; 35(S1). Teng TC, Teng TT, Bush BJ. .
      View in: Publisher Site   Mentions:
    13. Effects of EPHB receptors on facial morphology: non-additive interactions during mouse facial development. The FASEB Journal. 2021 May 14; 35(S1). Mincer MS, Niethamer NT, Teng TT, Bush BJ, Percival PC. .
      View in: Publisher Site   Mentions:
    14. NMDA receptors control development of somatosensory callosal axonal projections. Elife. 2021 03 04; 10. Zhou J, Lin Y, Huynh T, Noguchi H, Bush JO, Pleasure SJ. PMID: 33661095; PMCID: PMC7959694.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    15. YAP/TAZ Regulate Elevation and Bone Formation of the Mouse Secondary Palate. J Dent Res. 2020 11; 99(12):1387-1396. Goodwin AF, Chen CP, Vo NT, Bush JO, Klein OD. PMID: 32623954; PMCID: PMC7580170.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    16. Forced to communicate: Integration of mechanical and biochemical signaling in morphogenesis. Curr Opin Cell Biol. 2020 10; 66:59-68. Kindberg A, Hu JK, Bush JO. PMID: 32569947; PMCID: PMC7577940.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    17. Delineating the early transcriptional specification of the mammalian trachea and esophagus. Elife. 2020 06 09; 9. Kuwahara A, Lewis AE, Coombes C, Leung FS, Percharde M, Bush JO. PMID: 32515350; PMCID: PMC7282815.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    18. The UCSF Mouse Inventory Database Application, an Open Source Web App for Sharing Mutant Mice Within a Research Community. G3 (Bethesda). 2020 05 04; 10(5):1503-1510. Wall E, Scoles J, Joo A, Klein O, Quinonez C, Bush JO, Martin GR, Laird DJ. PMID: 32152007; PMCID: PMC7202022.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    19. Morphometric Analysis of Efnb1 Dependent Palate Growth. The FASEB Journal. 2020 Apr 1; 34(S1):1-1. O'Neill OM, Percival PC, Bush BJ. .
      View in: Publisher Site   Mentions:
    20. Aberrant cell segregation in the craniofacial primordium and the emergence of facial dysmorphology in craniofrontonasal syndrome. PLoS Genet. 2020 02; 16(2):e1008300. Niethamer TK, Teng T, Franco M, Du YX, Percival CJ, Bush JO. PMID: 32092051; PMCID: PMC7058351.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    21. Hypertelorism of Efnb1 Null Mice Occurs Independently of Changes to Underlying Brain Shape. The FASEB Journal. 2019 Apr 1; 33(S1):77.3-77.3. Percival PC, Devine DJ, Niethamer NT, Bush BJ. .
      View in: Publisher Site   Mentions:
    22. Cellular organization and boundary formation in craniofacial development. Genesis. 2019 01; 57(1):e23271. Kindberg AA, Bush JO. PMID: 30548771; PMCID: PMC6503678.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    23. WITHDRAWN: Editorial Introduction. Dev Biol. 2019 Jan 11. Bush JO, Andersson ER. PMID: 30639158.
      View in: PubMed   Mentions:    Fields:    
    24. Editorial: Signaling pathways instruct the blueprint of life. Dev Biol. 2019 03 01; 447(1):1-2. Bush JO, Andersson ER. PMID: 29885286.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    25. Getting direction(s): The Eph/ephrin signaling system in cell positioning. Dev Biol. 2019 03 01; 447(1):42-57. Niethamer TK, Bush JO. PMID: 29360434; PMCID: PMC6066467.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    26. Live Imaging of Mouse Secondary Palate Fusion. J Vis Exp. 2017 07 27; (125). Kim S, Prochazka J, Bush JO. PMID: 28784960; PMCID: PMC5613774.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    27. Cellular dynamics of tissue fusion in craniofacial development and orofacial clefting. The FASEB Journal. 2017 Apr 1; 31(S1). Bush BJ, Kim KS, Hagan HB. .
      View in: Publisher Site   Mentions:
    28. EPHRIN-B1 Mosaicism Drives Cell Segregation in Craniofrontonasal Syndrome hiPSC-Derived Neuroepithelial Cells. Stem Cell Reports. 2017 03 14; 8(3):529-537. Niethamer TK, Larson AR, O'Neill AK, Bershteyn M, Hsiao EC, Klein OD, Pomerantz JH, Bush JO. PMID: 28238796; PMCID: PMC5355632.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    29. Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation. J Cell Biol. 2016 Oct 24; 215(2):217-229. O'Neill AK, Kindberg AA, Niethamer TK, Larson AR, Ho HH, Greenberg ME, Bush JO. PMID: 27810913; PMCID: PMC5084648.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    30. From Bench to Bedside and Back: Improving Diagnosis and Treatment of Craniofacial Malformations Utilizing Animal Models. Curr Top Dev Biol. 2015; 115:459-92. Goodwin AF, Kim R, Bush JO, Klein OD. PMID: 26589935; PMCID: PMC7398124.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    31. Neural crest defects in ephrin-B2 mutant mice are non-autonomous and originate from defects in the vasculature. Dev Biol. 2015 Oct 15; 406(2):186-95. Lewis AE, Hwa J, Wang R, Soriano P, Bush JO. PMID: 26385750; PMCID: PMC4639416.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    32. Convergence and extrusion are required for normal fusion of the mammalian secondary palate. PLoS Biol. 2015 Apr; 13(4):e1002122. Kim S, Lewis AE, Singh V, Ma X, Adelstein R, Bush JO. PMID: 25848986; PMCID: PMC4388528.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    33. Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate. Dev Dyn. 2014 Nov; 243(11):1470-6. Agrawal P, Wang M, Kim S, Lewis AE, Bush JO. PMID: 25073978; PMCID: PMC4404412.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    34. Cell intercalation and migration mediated by actin contractility are key cellular behaviors in fusion of the mammalian secondary palate (344.2). The FASEB Journal. 2014 Apr 1; 28. Bush BJ, Kim KS. .
      View in: Publisher Site   Mentions:
    35. The society of craniofacial genetics and developmental biology 35th annual meeting. American Journal of Medical Genetics Part A. 2013 Dec 1; 161(12):2938-2952. Klein KO, Bush BJ, Knox KS, Jheon JA, Cordero CD, Richtsmeier RJ. .
      View in: Publisher Site   Mentions:
    36. The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling. Dev Biol. 2013 Jul 15; 379(2):229-34. Lewis AE, Vasudevan HN, O'Neill AK, Soriano P, Bush JO. PMID: 23648512; PMCID: PMC3804302.
      View in: PubMed   Mentions: 140     Fields:    Translation:AnimalsCells
    37. Ephrin B1 maintains apical adhesion of neural progenitors. Development. 2013 May; 140(10):2082-92. Arvanitis DN, Béhar A, Tryoen-Tóth P, Bush JO, Jungas T, Vitale N, Davy A. PMID: 23578932.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    38. Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development. Development. 2012 Jan; 139(2):231-43. Bush JO, Jiang R. PMID: 22186724; PMCID: PMC3243091.
      View in: PubMed   Mentions: 253     Fields:    Translation:Animals
    39. Eph/ephrin signaling: genetic, phosphoproteomic, and transcriptomic approaches. Semin Cell Dev Biol. 2012 Feb; 23(1):26-34. Bush JO, Soriano P. PMID: 22040918; PMCID: PMC3288612.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    40. Ephrin-B signaling in craniofacial development and disease. The FASEB Journal. 2011 Apr 1; 25:420.6-420.6. Bush BJ, Soriano SP. .
      View in: Publisher Site   Mentions:
    41. Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries. Genes Dev. 2010 Sep 15; 24(18):2068-80. Bush JO, Soriano P. PMID: 20844017; PMCID: PMC2939368.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    42. Analysis of signaling downstream of ephrin-B1 during development. Developmental Biology. 2009 Jul 1; 331(2):479. Bush BJ, Soriano SP. .
      View in: Publisher Site   Mentions:
    43. Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism. Genes Dev. 2009 Jul 01; 23(13):1586-99. Bush JO, Soriano P. PMID: 19515977; PMCID: PMC2704468.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    44. The TGF-beta pseudoreceptor gene Bambi is dispensable for mouse embryonic development and postnatal survival. Genesis. 2007 Aug; 45(8):482-6. Chen J, Bush JO, Ovitt CE, Lan Y, Jiang R. PMID: 17661381; PMCID: PMC2376806.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    45. Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies craniofrontonasal syndrome. PLoS Biol. 2006 Oct; 4(10):e315. Davy A, Bush JO, Soriano P. PMID: 16968134; PMCID: PMC1563491.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    46. Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice. Dev Dyn. 2006 May; 235(5):1448-54. Lan Y, Ryan RC, Zhang Z, Bullard SA, Bush JO, Maltby KM, Lidral AC, Jiang R. PMID: 16496313; PMCID: PMC2559872.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    47. Development of the upper lip: Morphogenetic and molecular mechanisms. Developmental Dynamics. 2006 May 1; 235(5):spc1-spc1. Jiang JR, Bush BJ, Lidral LA. .
      View in: Publisher Site   Mentions:
    48. Development of the upper lip: morphogenetic and molecular mechanisms. Dev Dyn. 2006 May; 235(5):1152-66. Jiang R, Bush JO, Lidral AC. PMID: 16292776; PMCID: PMC2562450.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansAnimalsCells
    49. The cleft lip and palate defects in Dancer mutant mice result from gain of function of the Tbx10 gene. Proc Natl Acad Sci U S A. 2004 May 04; 101(18):7022-7. Bush JO, Lan Y, Jiang R. PMID: 15118109; PMCID: PMC406459.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    50. The T-box gene Tbx10 exhibits a uniquely restricted expression pattern during mouse embryogenesis. Gene Expr Patterns. 2003 Aug; 3(4):533-8. Bush JO, Maltby KM, Cho ES, Jiang R. PMID: 12915323.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
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