Sarah Knox, PhD

Title(s)Professor, Cell and Tissue Biology
SchoolSchool of Dentistry
Address513 Parnassus Ave, HSE, #1505
San Francisco CA 94143
Phone415-502-0811
ORCID ORCID Icon0000-0002-7567-083X Additional info
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    Collapse Biography 
    Collapse Education and Training
    NIDCRPost-doctoral Fellow2011Laboratory of Cell and Developmental Biology
    University of NSWPhD2002Biomedical Engineering

    Collapse Research 
    Collapse Research Activities and Funding
    Lacritin Regulation of Homeostasis and Ocular Surface Health
    NIH R01EY032956Sep 1, 2021 - Jul 31, 2026
    Role: Co-Principal Investigator
    Defining mechanisms driving dry eye disease progression
    NIH R01EY033040Aug 1, 2021 - Jul 31, 2026
    Role: Principal Investigator
    2018 Salivary Glands and Exocrine Biology Gordon Research Conference and Seminar
    NIH R13DE028494Feb 1, 2019 - Jan 31, 2020
    Role: Principal Investigator
    Defining mechanisms driving salivary gland regeneration
    NIH R35DE028255Sep 18, 2018 - Jun 30, 2026
    Role: Principal Investigator
    Autonomic regulation of lacrimal stem cells
    NIH R01EY027392Sep 30, 2017 - Jun 30, 2021
    Role: Principal Investigator
    Defining the role of immune-neuronal crosstalk in dry eye disease
    NIH R01EY026492Sep 30, 2016 - Jul 31, 2020
    Role: Principal Investigator
    2016 Proteoglycans Gordon Research Conference & Gordon Research Seminar
    NIH R13AR069957May 1, 2016 - Apr 30, 2017
    Role: Principal Investigator
    Impact of aging on salivary stem cells and organ regeneration
    NIH R21DE025736Apr 1, 2016 - Mar 31, 2018
    Role: Principal Investigator
    Defining the role of the nervous system in aqueous-deficient dry eye
    NIH R01EY025980Aug 1, 2015 - Jun 30, 2021
    Role: Principal Investigator
    Neuronal regulation of salivary stem cells
    NIH R01DE024188Apr 1, 2014 - Dec 31, 2018
    Role: Principal Investigator
    Salivary gland repair and regeneration via Schwann cell-nerve interactions
    NIH R21DE022951Jul 20, 2012 - Jun 30, 2015
    Role: Principal Investigator
    Neuronal-epithelial interactions that regulate mouse salivary gland development
    NIH R00DE018969Jan 24, 2012 - Dec 31, 2015
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Featured Content 
    Collapse Featured Presentations

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
      Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
      Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
      1. The First Transcriptomic Atlas of the Adult Lacrimal Gland Reveals Epithelial Complexity and Identifies Novel Progenitor Cells in Mice. Cells. 2023 05 21; 12(10). Delcroix V, Mauduit O, Lee HS, Ivanova A, Umazume T, Knox SM, de Paiva CS, Dartt DA, Makarenkova HP. PMID: 37408269; PMCID: PMC10216974.
        View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
      2. Long-term functional regeneration of radiation-damaged salivary glands through delivery of a neurogenic hydrogel. Sci Adv. 2022 Dec 21; 8(51):eadc8753. Li J, Sudiwala S, Berthoin L, Mohabbat S, Gaylord EA, Sinada H, Cruz Pacheco N, Chang JC, Jeon O, Lombaert IMA, May AJ, Alsberg E, Bahney CS, Knox SM. PMID: 36542703; PMCID: PMC9770982.
        View in: PubMed   Mentions: 1     Fields:    
      3. Neuronal-epithelial cross-talk drives acinar specification via NRG1-ERBB3-mTORC2 signaling. Dev Cell. 2022 11 21; 57(22):2550-2565.e5. May AJ, Mattingly AJ, Gaylord EA, Griffin N, Sudiwala S, Cruz-Pacheco N, Emmerson E, Mohabbat S, Nathan S, Sinada H, Lombaert IMA, Knox SM. PMID: 36413949; PMCID: PMC9727910.
        View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
      4. A synthetic tear protein resolves dry eye through promoting corneal nerve regeneration. Cell Rep. 2022 08 30; 40(9):111307. Efraim Y, Chen FYT, Cheong KN, Gaylord EA, McNamara NA, Knox SM. PMID: 36044852; PMCID: PMC9549932.
        View in: PubMed   Mentions: 3     Fields:    Translation:Humans
      5. A mechanism of gene evolution generating mucin function. Sci Adv. 2022 08 26; 8(34):eabm8757. Pajic P, Shen S, Qu J, May AJ, Knox S, Ruhl S, Gokcumen O. PMID: 36026444; PMCID: PMC9417175.
        View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
      6. Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell phenotype. PNAS Nexus. 2022 May; 1(2):pgac056. Viswanathan V, Cao H, Saiki J, Jiang D, Mattingly A, Nambiar D, Bloomstein J, Li Y, Jiang S, Chamoli M, Sirjani D, Kaplan M, Holsinger FC, Liang R, Von Eyben R, Jiang H, Guan L, Lagory E, Feng Z, Nolan G, Ye J, Denko N, Knox S, Rosen DM, Le QT. PMID: 35707206; PMCID: PMC9186046.
        View in: PubMed   Mentions:
      7. Septum submucosal glands exhibit aberrant morphology and reduced mucin production in chronic rhinosinusitis. Int Forum Allergy Rhinol. 2021 10; 11(10):1443-1451. Nnabue OE, Pletcher SD, Gurrola JG, Goldberg AN, Jordan KM, Knox SM, May AJ. PMID: 33956392.
        View in: PubMed   Mentions:    Fields:    Translation:Humans
      8. Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva. Cell Rep. 2020 11 17; 33(7):108402. Saitou M, Gaylord EA, Xu E, May AJ, Neznanova L, Nathan S, Grawe A, Chang J, Ryan W, Ruhl S, Knox SM, Gokcumen O. PMID: 33207190; PMCID: PMC7703872.
        View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
      9. Alterations in corneal biomechanics underlie early stages of autoimmune-mediated dry eye disease. J Autoimmun. 2020 11; 114:102500. Efraim Y, Chen FYT, Stashko C, Cheong KN, Gaylord E, McNamara N, Knox SM. PMID: 32565048; PMCID: PMC8269964.
        View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
      10. 2155-P: Peripheral Nervous System Innervation of the Developing Pancreas. Diabetes. 2019 Jun 1; 68(Supplement 1):2155-p. LA O LS, BYRNES BL, WONG WD, KNOX KS, SNEDDON SJ. .
        View in: Publisher Site   Mentions:
      11. The emerging role of cranial nerves in shaping craniofacial development. Genesis. 2019 01; 57(1):e23282. Sudiwala S, Knox SM. PMID: 30628162; PMCID: PMC9216240.
        View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
      12. Deciphering Molecular and Phenotypic Changes Associated with Early Autoimmune Disease in the Aire-Deficient Mouse Model of Sjögren's Syndrome. Int J Mol Sci. 2018 Nov 17; 19(11). Chen FY, Gaylord E, McNamara N, Knox S. PMID: 30453645; PMCID: PMC6274681.
        View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
      13. Diverse progenitor cells preserve salivary gland ductal architecture after radiation-induced damage. Development. 2018 11 05; 145(21). May AJ, Cruz-Pacheco N, Emmerson E, Gaylord EA, Seidel K, Nathan S, Muench MO, Klein OD, Knox SM. PMID: 30305288; PMCID: PMC6240316.
        View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCellsPHPublic Health
      14. Lineage dynamics of murine pancreatic development at single-cell resolution. Nat Commun. 2018 09 25; 9(1):3922. Byrnes LE, Wong DM, Subramaniam M, Meyer NP, Gilchrist CL, Knox SM, Tward AD, Ye CJ, Sneddon JB. PMID: 30254276; PMCID: PMC6156586.
        View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
      15. Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes. Proc Natl Acad Sci U S A. 2018 06 12; 115(24):6279-6284. Saiki JP, Cao H, Van Wassenhove LD, Viswanathan V, Bloomstein J, Nambiar DK, Mattingly AJ, Jiang D, Chen CH, Stevens MC, Simmons AL, Park HS, von Eyben R, Kool ET, Sirjani D, Knox SM, Le QT, Mochly-Rosen D. PMID: 29794221; PMCID: PMC6004437.
        View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
      16. Salivary gland stem cells: A review of development, regeneration and cancer. Genesis. 2018 05; 56(5):e23211. Emmerson E, Knox SM. PMID: 29663717; PMCID: PMC5980780.
        View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
      17. Salivary glands regenerate after radiation injury through SOX2-mediated secretory cell replacement. EMBO Mol Med. 2018 03; 10(3). Emmerson E, May AJ, Berthoin L, Cruz-Pacheco N, Nathan S, Mattingly AJ, Chang JL, Ryan WR, Tward AD, Knox SM. PMID: 29335337; PMCID: PMC5840548.
        View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCellsPHPublic Health
      18. Aire-deficient mice provide a model of corneal and lacrimal gland neuropathy in Sjögren's syndrome. PLoS One. 2017; 12(9):e0184916. Chen FY, Lee A, Ge S, Nathan S, Knox SM, McNamara NA. PMID: 28926640; PMCID: PMC5605119.
        View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
      19. SOX2 regulates acinar cell development in the salivary gland. Elife. 2017 06 17; 6. Emmerson E, May AJ, Nathan S, Cruz-Pacheco N, Lizama CO, Maliskova L, Zovein AC, Shen Y, Muench MO, Knox SM. PMID: 28623666; PMCID: PMC5498133.
        View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
      20. Identification and characterization of a rich population of CD34+ mesenchymal stem/stromal cells in human parotid, sublingual and submandibular glands. Sci Rep. 2017 06 14; 7(1):3484. Togarrati PP, Sasaki RT, Abdel-Mohsen M, Dinglasan N, Deng X, Desai S, Emmerson E, Yee E, Ryan WR, da Silva MCP, Knox SM, Pillai SK, Muench MO. PMID: 28615711; PMCID: PMC5471181.
        View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
      21. Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland. Development. 2017 07 01; 144(13):2517-2528. Farmer DT, Nathan S, Finley JK, Shengyang Yu K, Emmerson E, Byrnes LE, Sneddon JB, McManus MT, Tward AD, Knox SM. PMID: 28576768; PMCID: PMC5536870.
        View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
      22. miR-205 is a critical regulator of lacrimal gland development. Dev Biol. 2017 07 01; 427(1):12-20. Farmer DT, Finley JK, Chen FY, Tarifeño-Saldivia E, McNamara NA, Knox SM, McManus MT. PMID: 28511845; PMCID: PMC9276161.
        View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
      23. Salivary gland development and disease. Wiley Interdiscip Rev Dev Biol. 2015 Nov-Dec; 4(6):573-90. Mattingly A, Finley JK, Knox SM. PMID: 25970268; PMCID: PMC9273040.
        View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
      24. Submandibular parasympathetic gangliogenesis requires sprouty-dependent Wnt signals from epithelial progenitors. Dev Cell. 2015 Mar 23; 32(6):667-77. Knosp WM, Knox SM, Lombaert IM, Haddox CL, Patel VN, Hoffman MP. PMID: 25805134; PMCID: PMC4374127.
        View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
      25. Manipulating the murine lacrimal gland. J Vis Exp. 2014 Nov 18; (93):e51970. Finley JK, Farmer D, Emmerson E, Cruz Pacheco N, Knox SM. PMID: 25490187; PMCID: PMC4354001.
        View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
      26. Manipulating the Murine Lacrimal Gland. Journal of Visualized Experiments. 2014 Nov 18; (93). Finley FJ, Farmer FD, Emmerson EE, Cruz Pacheco CN, Knox KS. .
        View in: Publisher Site   Mentions:
      27. Parasympathetic innervation regulates tubulogenesis in the developing salivary gland. Dev Cell. 2014 Aug 25; 30(4):449-62. Nedvetsky PI, Emmerson E, Finley JK, Ettinger A, Cruz-Pacheco N, Prochazka J, Haddox CL, Northrup E, Hodges C, Mostov KE, Hoffman MP, Knox SM. PMID: 25158854; PMCID: PMC4155578.
        View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
      28. The society of craniofacial genetics and developmental biology 35th annual meeting. American Journal of Medical Genetics Part A. 2013 Dec 1; 161(12):2938-2952. Klein KO, Bush BJ, Knox KS, Jheon JA, Cordero CD, Richtsmeier RJ. .
        View in: Publisher Site   Mentions:
      29. Parasympathetic stimulation improves epithelial organ regeneration. Nat Commun. 2013; 4:1494. Knox SM, Lombaert IM, Haddox CL, Abrams SR, Cotrim A, Wilson AJ, Hoffman MP. PMID: 23422662; PMCID: PMC3582394.
        View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
      30. Salivary gland organogenesis. Wiley Interdiscip Rev Dev Biol. 2012 Jan-Feb; 1(1):69-82. Knosp WM, Knox SM, Hoffman MP. PMID: 23801668.
        View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
      31. Salivary gland progenitor cell biology provides a rationale for therapeutic salivary gland regeneration. Oral Dis. 2011 Jul; 17(5):445-9. Lombaert IM, Knox SM, Hoffman MP. PMID: 21223454; PMCID: PMC3375332.
        View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
      32. Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis. Science. 2010 Sep 24; 329(5999):1645-7. Knox SM, Lombaert IM, Reed X, Vitale-Cross L, Gutkind JS, Hoffman MP. PMID: 20929848; PMCID: PMC3376907.
        View in: PubMed   Mentions: 181     Fields:    Translation:AnimalsCells
      33. Recombinant heparan sulfate for use in tissue engineering applications. Journal of Chemical Technology & Biotechnology. 2008 Apr 1; 83(4):496-504. Whitelock WJ, Leo LJ, Davies DN, Nielsen NN, Chuang CC, Rees RM, Iozzo IR, Knox KS, Lord LM. .
        View in: Publisher Site   Mentions:
      34. Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. Development. 2007 Dec; 134(23):4177-86. Patel VN, Knox SM, Likar KM, Lathrop CA, Hossain R, Eftekhari S, Whitelock JM, Elkin M, Vlodavsky I, Hoffman MP. PMID: 17959718.
        View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
      35. The function of a Drosophila glypican does not depend entirely on heparan sulfate modification. Dev Biol. 2006 Dec 15; 300(2):570-82. Kirkpatrick CA, Knox SM, Staatz WD, Fox B, Lercher DM, Selleck SB. PMID: 17055473.
        View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
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