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Sarah Knox, PhD

Title(s)Professor, Cell and Tissue Biology
SchoolSchool of Dentistry
Address513 Parnassus Avenue, HSE, #1510
San Francisco CA 94143
Phone415-502-0811
ORCID ORCID Icon0000-0002-7567-083X Additional info
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    Collapse Biography 
    Collapse education and training
    NIDCRPost-doctoral Fellow2011Laboratory of Cell and Developmental Biology
    University of NSWPhD2002Biomedical Engineering

    Collapse Overview 
    Collapse overview
    The Knox Lab research program investigates the role of peripheral nerves in controlling epithelial organ development, regeneration, and chronic disease (autoimmune disease, aging, cancer). To explore these areas, we utilize a multiorgan approach that includes the salivary glands and cornea. Our experimental approach employs a bevy of tools that define cell identity, cell-cell relationships and cell/tissue behavior during development and response to injury and regenerative cues including mouse genetics, single cell/bulk RNA sequencing, organoids, atomic force microscopy, ex vivo organ culture, hydrogel synthesis (mechanical, physical and biological testing etc.) and high-resolution imaging. Using this strategy, we have discovered essential functions of peripheral nerves in regulating stem cell maintenance, differentiation and maturation, tissue morphogenesis and regeneration, and cell lineage outcomes. We have also uncovered multiple aspects of nerve-epithelial cell interactions and factors that drive reinnervation. Importantly, our basic research has led to the initiation of translational projects. For example, based on our recent discovery of a nerve-derived factor that promotes glandular repair after radiation-induced damage, we designed a drug-hydrogel system that provides local penetration of irradiated tissue for achieving long-term functional and structural regeneration. This therapeutic product has the potential to regenerate the salivary glands of patients who have received radiotherapy for head and neck cancer, an off target injury for which there are no regenerative therapies, and poor palliative therapies. These studies are funded by the CDOCTOR/NIDCR program and the California Institute for Regenerative Medicine translational award (TRAN1). We have conducted a pre-IND and are currently performing a pre-clinical trial in 2 large animal models (dog and rabbit) to meet the needs of the FDA for clinical translation.
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    Collapse Research 
    Collapse research activities and funding
    Lacritin Regulation of Homeostasis and Ocular Surface Health
    NIH R01EY032956Sep 1, 2021 - Jul 31, 2026
    Role: Co-Principal Investigator
    Defining mechanisms driving dry eye disease progression
    NIH R01EY033040Aug 1, 2021 - Jul 31, 2026
    Role: Principal Investigator
    2018 Salivary Glands and Exocrine Biology Gordon Research Conference and Seminar
    NIH R13DE028494Feb 1, 2019 - Jan 31, 2020
    Role: Principal Investigator
    Defining mechanisms driving salivary gland regeneration
    NIH R35DE028255Sep 18, 2018 - Jun 30, 2026
    Role: Principal Investigator
    Autonomic regulation of lacrimal stem cells
    NIH R01EY027392Sep 30, 2017 - Jun 30, 2021
    Role: Principal Investigator
    Defining the role of immune-neuronal crosstalk in dry eye disease
    NIH R01EY026492Sep 30, 2016 - Jul 31, 2020
    Role: Principal Investigator
    2016 Proteoglycans Gordon Research Conference & Gordon Research Seminar
    NIH R13AR069957May 1, 2016 - Apr 30, 2017
    Role: Principal Investigator
    Impact of aging on salivary stem cells and organ regeneration
    NIH R21DE025736Apr 1, 2016 - Mar 31, 2018
    Role: Principal Investigator
    Defining the role of the nervous system in aqueous-deficient dry eye
    NIH R01EY025980Aug 1, 2015 - Jun 30, 2021
    Role: Principal Investigator
    Neuronal regulation of salivary stem cells
    NIH R01DE024188Apr 1, 2014 - Dec 31, 2018
    Role: Principal Investigator
    Salivary gland repair and regeneration via Schwann cell-nerve interactions
    NIH R21DE022951Jul 20, 2012 - Jun 30, 2015
    Role: Principal Investigator
    Neuronal-epithelial interactions that regulate mouse salivary gland development
    NIH R00DE018969Jan 24, 2012 - Dec 31, 2015
    Role: Principal Investigator

    Collapse Featured Content 
    Collapse Featured Presentations

      Collapse Bibliographic 
      Collapse selected publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
      Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
      Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
      1. Correction: An FGFR-p53 developmental signaling axis drives salivary cancer progression. Oncogene. 2025 Aug; 44(32):2924. Musicant AM, Billington JMR, Damrauer JS, Modliszewski JL, Landau LJB, Tsai YH, Mehta JH, Powers J, Betancourt R, Sekhri R, Padilla RJ, Hernandez-Prera JC, Hayes DN, Hackman TG, Gokcumen O, Knox SM, Amelio AL. PMID: 40542202.
        View in: PubMed   Mentions:    Fields:    
      2. An FGFR-p53 developmental signaling axis drives salivary cancer progression. Oncogene. 2025 Jun 02. Musicant AM, Billington JMR, Damrauer JS, Modliszewski JL, Landuau LJB, Tsai YH, Mehta JH, Powers J, Betancourt R, Sekhri R, Padilla RJ, Hernandez-Prera JC, Hayes DN, Hackman TG, Gokcumen O, Knox SM, Amelio AL. PMID: 40456865.
        View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
      3. Rescue of non-healing, degenerative salivary glands by cholinergic-calcium signaling. bioRxiv. 2025 Feb 28. Li J, Sun B, Tan LX, Griffin N, Niknezhad SV, Yu C, Berthoin L, Cruz-Pacheco N, Mohabbat S, Sinada H, Efraim Y, Chen FYT, An L, Gaylord EA, Bahney CS, Lombaert IMA, Knox SM. PMID: 39803569; PMCID: PMC11722244.
        View in: PubMed   Mentions:
      4. Rebuilding the autoimmune-damaged corneal stroma through topical lubrication. bioRxiv. 2024 Dec 03. Efraim Y, Chen FYT, Niknezhad SV, Pham D, Cheong KN, An L, Sinada H, McNamara NA, Knox SM. PMID: 39677756; PMCID: PMC11642755.
        View in: PubMed   Mentions:
      5. Methane fluxes in tidal marshes of the conterminous United States. Glob Chang Biol. 2024 Sep; 30(9):e17462. Arias-Ortiz A, Wolfe J, Bridgham SD, Knox S, McNicol G, Needelman BA, Shahan J, Stuart-Haëntjens EJ, Windham-Myers L, Oikawa PY, Baldocchi DD, Caplan JS, Capooci M, Czapla KM, Derby RK, Diefenderfer HL, Forbrich I, Groseclose G, Keller JK, Kelley C, Keshta AE, Kleiner HS, Krauss KW, Lane RR, Mack S, Moseman-Valtierra S, Mozdzer TJ, Mueller P, Neubauer SC, Noyce G, Schäfer KVR, Sanders-DeMott R, Schutte CA, Vargas R, Weston NB, Wilson B, Megonigal JP, Holmquist JR. PMID: 39234688.
        View in: PubMed   Mentions: 1     Fields:    Translation:PHPublic Health
      6. Practical Guide to Measuring Wetland Carbon Pools and Fluxes. Wetlands (Wilmington). 2023; 43(8):105. Bansal S, Creed IF, Tangen BA, Bridgham SD, Desai AR, Krauss KW, Neubauer SC, Noe GB, Rosenberry DO, Trettin C, Wickland KP, Allen ST, Arias-Ortiz A, Armitage AR, Baldocchi D, Banerjee K, Bastviken D, Berg P, Bogard MJ, Chow AT, Conner WH, Craft C, Creamer C, DelSontro T, Duberstein JA, Eagle M, Fennessy MS, Finkelstein SA, Göckede M, Grunwald S, Halabisky M, Herbert E, Jahangir MMR, Johnson OF, Jones MC, Kelleway JJ, Knox S, Kroeger KD, Kuehn KA, Lobb D, Loder AL, Ma S, Maher DT, McNicol G, Meier J, Middleton BA, Mills C, Mistry P, Mitra A, Mobilian C, Nahlik AM, Newman S, O'Connell JL, Oikawa P, van der Burg MP, Schutte CA, Song C, Stagg CL, Turner J, Vargas R, Waldrop MP, Wallin MB, Wang ZA, Ward EJ, Willard DA, Yarwood S, Zhu X. PMID: 38037553; PMCID: PMC10684704.
        View in: PubMed   Mentions: 8  
      7. The First Transcriptomic Atlas of the Adult Lacrimal Gland Reveals Epithelial Complexity and Identifies Novel Progenitor Cells in Mice. Cells. 2023 05 21; 12(10). Delcroix V, Mauduit O, Lee HS, Ivanova A, Umazume T, Knox SM, de Paiva CS, Dartt DA, Makarenkova HP. PMID: 37408269; PMCID: PMC10216974.
        View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
      8. Long-term functional regeneration of radiation-damaged salivary glands through delivery of a neurogenic hydrogel. Sci Adv. 2022 Dec 21; 8(51):eadc8753. Li J, Sudiwala S, Berthoin L, Mohabbat S, Gaylord EA, Sinada H, Cruz Pacheco N, Chang JC, Jeon O, Lombaert IMA, May AJ, Alsberg E, Bahney CS, Knox SM. PMID: 36542703; PMCID: PMC9770982.
        View in: PubMed   Mentions: 10     Fields:    
      9. Neuronal-epithelial cross-talk drives acinar specification via NRG1-ERBB3-mTORC2 signaling. Dev Cell. 2022 11 21; 57(22):2550-2565.e5. May AJ, Mattingly AJ, Gaylord EA, Griffin N, Sudiwala S, Cruz-Pacheco N, Emmerson E, Mohabbat S, Nathan S, Sinada H, Lombaert IMA, Knox SM. PMID: 36413949; PMCID: PMC9727910.
        View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
      10. A synthetic tear protein resolves dry eye through promoting corneal nerve regeneration. Cell Rep. 2022 08 30; 40(9):111307. Efraim Y, Chen FYT, Cheong KN, Gaylord EA, McNamara NA, Knox SM. PMID: 36044852; PMCID: PMC9549932.
        View in: PubMed   Mentions: 10     Fields:    Translation:Humans
      11. A mechanism of gene evolution generating mucin function. Sci Adv. 2022 08 26; 8(34):eabm8757. Pajic P, Shen S, Qu J, May AJ, Knox S, Ruhl S, Gokcumen O. PMID: 36026444; PMCID: PMC9417175.
        View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
      12. Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell phenotype. PNAS Nexus. 2022 May; 1(2):pgac056. Viswanathan V, Cao H, Saiki J, Jiang D, Mattingly A, Nambiar D, Bloomstein J, Li Y, Jiang S, Chamoli M, Sirjani D, Kaplan M, Holsinger FC, Liang R, Von Eyben R, Jiang H, Guan L, Lagory E, Feng Z, Nolan G, Ye J, Denko N, Knox S, Rosen DM, Le QT. PMID: 35707206; PMCID: PMC9186046.
        View in: PubMed   Mentions: 2  
      13. Exocrine gland structure-function relationships. Development. 2022 01 01; 149(1). Khan S, Fitch S, Knox S, Arora R. PMID: 34989394.
        View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
      14. Anthropogenic emission is the main contributor to the rise of atmospheric methane during 1993-2017. Natl Sci Rev. 2022 May; 9(5):nwab200. Zhang Z, Poulter B, Knox S, Stavert A, McNicol G, Fluet-Chouinard E, Feinberg A, Zhao Y, Bousquet P, Canadell JG, Ganesan A, Hugelius G, Hurtt G, Jackson RB, Patra PK, Saunois M, Höglund-Isaksson L, Huang C, Chatterjee A, Li X. PMID: 35547958; PMCID: PMC9084358.
        View in: PubMed   Mentions: 6  
      15. Septum submucosal glands exhibit aberrant morphology and reduced mucin production in chronic rhinosinusitis. Int Forum Allergy Rhinol. 2021 10; 11(10):1443-1451. Nnabue OE, Pletcher SD, Gurrola JG, Goldberg AN, Jordan KM, Knox SM, May AJ. PMID: 33956392.
        View in: PubMed   Mentions: 1     Fields:    Translation:Humans
      16. Author Correction: The FLUXNET2015 dataset and the ONEFlux processing pipeline for eddy covariance data. Sci Data. 2021 Feb 25; 8(1):72. Pastorello G, Trotta C, Canfora E, Chu H, Christianson D, Cheah YW, Poindexter C, Chen J, Elbashandy A, Humphrey M, Isaac P, Polidori D, Reichstein M, Ribeca A, van Ingen C, Vuichard N, Zhang L, Amiro B, Ammann C, Arain MA, Ardö J, Arkebauer T, Arndt SK, Arriga N, Aubinet M, Aurela M, Baldocchi D, Barr A, Beamesderfer E, Marchesini LB, Bergeron O, Beringer J, Bernhofer C, Berveiller D, Billesbach D, Black TA, Blanken PD, Bohrer G, Boike J, Bolstad PV, Bonal D, Bonnefond JM, Bowling DR, Bracho R, Brodeur J, Brümmer C, Buchmann N, Burban B, Burns SP, Buysse P, Cale P, Cavagna M, Cellier P, Chen S, Chini I, Christensen TR, Cleverly J, Collalti A, Consalvo C, Cook BD, Cook D, Coursolle C, Cremonese E, Curtis PS, D'Andrea E, da Rocha H, Dai X, Davis KJ, De Cinti B, de Grandcourt A, De Ligne A, De Oliveira RC, Delpierre N, Desai AR, Di Bella CM, di Tommasi P, Dolman H, Domingo F, Dong G, Dore S, Duce P, Dufrêne E, Dunn A, Dušek J, Eamus D, Eichelmann U, ElKhidir HAM, Eugster W, Ewenz CM, Ewers B, Famulari D, Fares S, Feigenwinter I, Feitz A, Fensholt R, Filippa G, Fischer M, Frank J, Galvagno M, Gharun M, Gianelle D, Gielen B, Gioli B, Gitelson A, Goded I, Goeckede M, Goldstein AH, Gough CM, Goulden ML, Graf A, Griebel A, Gruening C, Grünwald T, Hammerle A, Han S, Han X, Hansen BU, Hanson C, Hatakka J, He Y, Hehn M, Heinesch B, Hinko-Najera N, Hörtnagl L, Hutley L, Ibrom A, Ikawa H, Jackowicz-Korczynski M, Janouš D, Jans W, Jassal R, Jiang S, Kato T, Khomik M, Klatt J, Knohl A, Knox S, Kobayashi H, Koerber G, Kolle O, Kosugi Y, Kotani A, Kowalski A, Kruijt B, Kurbatova J, Kutsch WL, Kwon H, Launiainen S, Laurila T, Law B, Leuning R, Li Y, Liddell M, Limousin JM, Lion M, Liska AJ, Lohila A, López-Ballesteros A, López-Blanco E, Loubet B, Loustau D, Lucas-Moffat A, Lüers J, Ma S, Macfarlane C, Magliulo V, Maier R, Mammarella I, Manca G, Marcolla B, Margolis HA, Marras S, Massman W, Mastepanov M, Matamala R, Matthes JH, Mazzenga F, McCaughey H, McHugh I, McMillan AMS, Merbold L, Meyer W, Meyers T, Miller SD, Minerbi S, Moderow U, Monson RK, Montagnani L, Moore CE, Moors E, Moreaux V, Moureaux C, Munger JW, Nakai T, Neirynck J, Nesic Z, Nicolini G, Noormets A, Northwood M, Nosetto M, Nouvellon Y, Novick K, Oechel W, Olesen JE, Ourcival JM, Papuga SA, Parmentier FJ, Paul-Limoges E, Pavelka M, Peichl M, Pendall E, Phillips RP, Pilegaard K, Pirk N, Posse G, Powell T, Prasse H, Prober SM, Rambal S, Rannik Ü, Raz-Yaseef N, Rebmann C, Reed D, de Dios VR, Restrepo-Coupe N, Reverter BR, Roland M, Sabbatini S, Sachs T, Saleska SR, Sánchez-Cañete EP, Sanchez-Mejia ZM, Schmid HP, Schmidt M, Schneider K, Schrader F, Schroder I, Scott RL, Sedlák P, Serrano-Ortíz P, Shao C, Shi P, Shironya I, Siebicke L, Šigut L, Silberstein R, Sirca C, Spano D, Steinbrecher R, Stevens RM, Sturtevant C, Suyker A, Tagesson T, Takanashi S, Tang Y, Tapper N, Thom J, Tomassucci M, Tuovinen JP, Urbanski S, Valentini R, van der Molen M, van Gorsel E, van Huissteden K, Varlagin A, Verfaillie J, Vesala T, Vincke C, Vitale D, Vygodskaya N, Walker JP, Walter-Shea E, Wang H, Weber R, Westermann S, Wille C, Wofsy S, Wohlfahrt G, Wolf S, Woodgate W, Li Y, Zampedri R, Zhang J, Zhou G, Zona D, Agarwal D, Biraud S, Torn M, Papale D. PMID: 33633116; PMCID: PMC7907353.
        View in: PubMed   Mentions:    Fields:    
      17. Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva. Cell Rep. 2020 11 17; 33(7):108402. Saitou M, Gaylord EA, Xu E, May AJ, Neznanova L, Nathan S, Grawe A, Chang J, Ryan W, Ruhl S, Knox SM, Gokcumen O. PMID: 33207190; PMCID: PMC7703872.
        View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
      18. The FLUXNET2015 dataset and the ONEFlux processing pipeline for eddy covariance data. Sci Data. 2020 07 09; 7(1):225. Pastorello G, Trotta C, Canfora E, Chu H, Christianson D, Cheah YW, Poindexter C, Chen J, Elbashandy A, Humphrey M, Isaac P, Polidori D, Reichstein M, Ribeca A, van Ingen C, Vuichard N, Zhang L, Amiro B, Ammann C, Arain MA, Ardö J, Arkebauer T, Arndt SK, Arriga N, Aubinet M, Aurela M, Baldocchi D, Barr A, Beamesderfer E, Marchesini LB, Bergeron O, Beringer J, Bernhofer C, Berveiller D, Billesbach D, Black TA, Blanken PD, Bohrer G, Boike J, Bolstad PV, Bonal D, Bonnefond JM, Bowling DR, Bracho R, Brodeur J, Brümmer C, Buchmann N, Burban B, Burns SP, Buysse P, Cale P, Cavagna M, Cellier P, Chen S, Chini I, Christensen TR, Cleverly J, Collalti A, Consalvo C, Cook BD, Cook D, Coursolle C, Cremonese E, Curtis PS, D'Andrea E, da Rocha H, Dai X, Davis KJ, Cinti B, Grandcourt A, Ligne A, De Oliveira RC, Delpierre N, Desai AR, Di Bella CM, Tommasi PD, Dolman H, Domingo F, Dong G, Dore S, Duce P, Dufrêne E, Dunn A, Dušek J, Eamus D, Eichelmann U, ElKhidir HAM, Eugster W, Ewenz CM, Ewers B, Famulari D, Fares S, Feigenwinter I, Feitz A, Fensholt R, Filippa G, Fischer M, Frank J, Galvagno M, Gharun M, Gianelle D, Gielen B, Gioli B, Gitelson A, Goded I, Goeckede M, Goldstein AH, Gough CM, Goulden ML, Graf A, Griebel A, Gruening C, Grünwald T, Hammerle A, Han S, Han X, Hansen BU, Hanson C, Hatakka J, He Y, Hehn M, Heinesch B, Hinko-Najera N, Hörtnagl L, Hutley L, Ibrom A, Ikawa H, Jackowicz-Korczynski M, Janouš D, Jans W, Jassal R, Jiang S, Kato T, Khomik M, Klatt J, Knohl A, Knox S, Kobayashi H, Koerber G, Kolle O, Kosugi Y, Kotani A, Kowalski A, Kruijt B, Kurbatova J, Kutsch WL, Kwon H, Launiainen S, Laurila T, Law B, Leuning R, Li Y, Liddell M, Limousin JM, Lion M, Liska AJ, Lohila A, López-Ballesteros A, López-Blanco E, Loubet B, Loustau D, Lucas-Moffat A, Lüers J, Ma S, Macfarlane C, Magliulo V, Maier R, Mammarella I, Manca G, Marcolla B, Margolis HA, Marras S, Massman W, Mastepanov M, Matamala R, Matthes JH, Mazzenga F, McCaughey H, McHugh I, McMillan AMS, Merbold L, Meyer W, Meyers T, Miller SD, Minerbi S, Moderow U, Monson RK, Montagnani L, Moore CE, Moors E, Moreaux V, Moureaux C, Munger JW, Nakai T, Neirynck J, Nesic Z, Nicolini G, Noormets A, Northwood M, Nosetto M, Nouvellon Y, Novick K, Oechel W, Olesen JE, Ourcival JM, Papuga SA, Parmentier FJ, Paul-Limoges E, Pavelka M, Peichl M, Pendall E, Phillips RP, Pilegaard K, Pirk N, Posse G, Powell T, Prasse H, Prober SM, Rambal S, Rannik Ü, Raz-Yaseef N, Rebmann C, Reed D, Dios VR, Restrepo-Coupe N, Reverter BR, Roland M, Sabbatini S, Sachs T, Saleska SR, Sánchez-Cañete EP, Sanchez-Mejia ZM, Schmid HP, Schmidt M, Schneider K, Schrader F, Schroder I, Scott RL, Sedlák P, Serrano-Ortíz P, Shao C, Shi P, Shironya I, Siebicke L, Šigut L, Silberstein R, Sirca C, Spano D, Steinbrecher R, Stevens RM, Sturtevant C, Suyker A, Tagesson T, Takanashi S, Tang Y, Tapper N, Thom J, Tomassucci M, Tuovinen JP, Urbanski S, Valentini R, van der Molen M, van Gorsel E, van Huissteden K, Varlagin A, Verfaillie J, Vesala T, Vincke C, Vitale D, Vygodskaya N, Walker JP, Walter-Shea E, Wang H, Weber R, Westermann S, Wille C, Wofsy S, Wohlfahrt G, Wolf S, Woodgate W, Li Y, Zampedri R, Zhang J, Zhou G, Zona D, Agarwal D, Biraud S, Torn M, Papale D. PMID: 32647314; PMCID: PMC7347557.
        View in: PubMed   Mentions: 131     Fields:    
      19. Alterations in corneal biomechanics underlie early stages of autoimmune-mediated dry eye disease. J Autoimmun. 2020 11; 114:102500. Efraim Y, Chen FYT, Stashko C, Cheong KN, Gaylord E, McNamara N, Knox SM. PMID: 32565048; PMCID: PMC8269964.
        View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
      20. Actigraphy-Based Assessment of Sleep Parameters. Ann Work Expo Health. 2020 04 30; 64(4):350-367. Fekedulegn D, Andrew ME, Shi M, Violanti JM, Knox S, Innes KE. PMID: 32053169; PMCID: PMC7191872.
        View in: PubMed   Mentions: 83     Fields:    Translation:Humans
      21. 2155-P: Peripheral Nervous System Innervation of the Developing Pancreas. Diabetes. 2019 Jun 1; 68(Supplement 1):2155-p. LA O LS, BYRNES BL, WONG WD, KNOX KS, SNEDDON SJ. .
        View in: Publisher Site   Mentions:
      22. The emerging role of cranial nerves in shaping craniofacial development. Genesis. 2019 01; 57(1):e23282. Sudiwala S, Knox SM. PMID: 30628162; PMCID: PMC9216240.
        View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
      23. Deciphering Molecular and Phenotypic Changes Associated with Early Autoimmune Disease in the Aire-Deficient Mouse Model of Sjögren's Syndrome. Int J Mol Sci. 2018 Nov 17; 19(11). Chen FY, Gaylord E, McNamara N, Knox S. PMID: 30453645; PMCID: PMC6274681.
        View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
      24. Diverse progenitor cells preserve salivary gland ductal architecture after radiation-induced damage. Development. 2018 11 05; 145(21). May AJ, Cruz-Pacheco N, Emmerson E, Gaylord EA, Seidel K, Nathan S, Muench MO, Klein OD, Knox SM. PMID: 30305288; PMCID: PMC6240316.
        View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCellsPHPublic Health
      25. Lineage dynamics of murine pancreatic development at single-cell resolution. Nat Commun. 2018 09 25; 9(1):3922. Byrnes LE, Wong DM, Subramaniam M, Meyer NP, Gilchrist CL, Knox SM, Tward AD, Ye CJ, Sneddon JB. PMID: 30254276; PMCID: PMC6156586.
        View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
      26. Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes. Proc Natl Acad Sci U S A. 2018 06 12; 115(24):6279-6284. Saiki JP, Cao H, Van Wassenhove LD, Viswanathan V, Bloomstein J, Nambiar DK, Mattingly AJ, Jiang D, Chen CH, Stevens MC, Simmons AL, Park HS, von Eyben R, Kool ET, Sirjani D, Knox SM, Le QT, Mochly-Rosen D. PMID: 29794221; PMCID: PMC6004437.
        View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
      27. Salivary gland stem cells: A review of development, regeneration and cancer. Genesis. 2018 05; 56(5):e23211. Emmerson E, Knox SM. PMID: 29663717; PMCID: PMC5980780.
        View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
      28. Salivary glands regenerate after radiation injury through SOX2-mediated secretory cell replacement. EMBO Mol Med. 2018 03; 10(3). Emmerson E, May AJ, Berthoin L, Cruz-Pacheco N, Nathan S, Mattingly AJ, Chang JL, Ryan WR, Tward AD, Knox SM. PMID: 29335337; PMCID: PMC5840548.
        View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCellsPHPublic Health
      29. Aire-deficient mice provide a model of corneal and lacrimal gland neuropathy in Sjögren's syndrome. PLoS One. 2017; 12(9):e0184916. Chen FY, Lee A, Ge S, Nathan S, Knox SM, McNamara NA. PMID: 28926640; PMCID: PMC5605119.
        View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
      30. SOX2 regulates acinar cell development in the salivary gland. Elife. 2017 06 17; 6. Emmerson E, May AJ, Nathan S, Cruz-Pacheco N, Lizama CO, Maliskova L, Zovein AC, Shen Y, Muench MO, Knox SM. PMID: 28623666; PMCID: PMC5498133.
        View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
      31. Identification and characterization of a rich population of CD34+ mesenchymal stem/stromal cells in human parotid, sublingual and submandibular glands. Sci Rep. 2017 06 14; 7(1):3484. Togarrati PP, Sasaki RT, Abdel-Mohsen M, Dinglasan N, Deng X, Desai S, Emmerson E, Yee E, Ryan WR, da Silva MCP, Knox SM, Pillai SK, Muench MO. PMID: 28615711; PMCID: PMC5471181.
        View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
      32. Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland. Development. 2017 07 01; 144(13):2517-2528. Farmer DT, Nathan S, Finley JK, Shengyang Yu K, Emmerson E, Byrnes LE, Sneddon JB, McManus MT, Tward AD, Knox SM. PMID: 28576768; PMCID: PMC5536870.
        View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
      33. miR-205 is a critical regulator of lacrimal gland development. Dev Biol. 2017 07 01; 427(1):12-20. Farmer DT, Finley JK, Chen FY, Tarifeño-Saldivia E, McNamara NA, Knox SM, McManus MT. PMID: 28511845; PMCID: PMC9276161.
        View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
      34. Salivary gland development and disease. Wiley Interdiscip Rev Dev Biol. 2015 Nov-Dec; 4(6):573-90. Mattingly A, Finley JK, Knox SM. PMID: 25970268; PMCID: PMC9273040.
        View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
      35. Submandibular parasympathetic gangliogenesis requires sprouty-dependent Wnt signals from epithelial progenitors. Dev Cell. 2015 Mar 23; 32(6):667-77. Knosp WM, Knox SM, Lombaert IM, Haddox CL, Patel VN, Hoffman MP. PMID: 25805134; PMCID: PMC4374127.
        View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
      36. Manipulating the murine lacrimal gland. J Vis Exp. 2014 Nov 18; (93):e51970. Finley JK, Farmer D, Emmerson E, Cruz Pacheco N, Knox SM. PMID: 25490187; PMCID: PMC4354001.
        View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
      37. Manipulating the Murine Lacrimal Gland. Journal of Visualized Experiments. 2014 Nov 18; (93). Finley FJ, Farmer FD, Emmerson EE, Cruz Pacheco CN, Knox KS. .
        View in: Publisher Site   Mentions:
      38. Parasympathetic innervation regulates tubulogenesis in the developing salivary gland. Dev Cell. 2014 Aug 25; 30(4):449-62. Nedvetsky PI, Emmerson E, Finley JK, Ettinger A, Cruz-Pacheco N, Prochazka J, Haddox CL, Northrup E, Hodges C, Mostov KE, Hoffman MP, Knox SM. PMID: 25158854; PMCID: PMC4155578.
        View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
      39. The society of craniofacial genetics and developmental biology 35th annual meeting. American Journal of Medical Genetics Part A. 2013 Dec 1; 161(12):2938-2952. Klein KO, Bush BJ, Knox KS, Jheon JA, Cordero CD, Richtsmeier RJ. .
        View in: Publisher Site   Mentions:
      40. Parasympathetic stimulation improves epithelial organ regeneration. Nat Commun. 2013; 4:1494. Knox SM, Lombaert IM, Haddox CL, Abrams SR, Cotrim A, Wilson AJ, Hoffman MP. PMID: 23422662; PMCID: PMC3582394.
        View in: PubMed   Mentions: 117     Fields:    Translation:HumansAnimalsCells
      41. Salivary gland organogenesis. Wiley Interdiscip Rev Dev Biol. 2012 Jan-Feb; 1(1):69-82. Knosp WM, Knox SM, Hoffman MP. PMID: 23801668.
        View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
      42. Salivary gland progenitor cell biology provides a rationale for therapeutic salivary gland regeneration. Oral Dis. 2011 Jul; 17(5):445-9. Lombaert IM, Knox SM, Hoffman MP. PMID: 21223454; PMCID: PMC3375332.
        View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
      43. Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis. Science. 2010 Sep 24; 329(5999):1645-7. Knox SM, Lombaert IM, Reed X, Vitale-Cross L, Gutkind JS, Hoffman MP. PMID: 20929848; PMCID: PMC3376907.
        View in: PubMed   Mentions: 196     Fields:    Translation:AnimalsCells
      44. Recombinant heparan sulfate for use in tissue engineering applications. Journal of Chemical Technology & Biotechnology. 2008 Apr 1; 83(4):496-504. Whitelock WJ, Leo LJ, Davies DN, Nielsen NN, Chuang CC, Rees RM, Iozzo IR, Knox KS, Lord LM. .
        View in: Publisher Site   Mentions:
      45. Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. Development. 2007 Dec; 134(23):4177-86. Patel VN, Knox SM, Likar KM, Lathrop CA, Hossain R, Eftekhari S, Whitelock JM, Elkin M, Vlodavsky I, Hoffman MP. PMID: 17959718.
        View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
      46. The function of a Drosophila glypican does not depend entirely on heparan sulfate modification. Dev Biol. 2006 Dec 15; 300(2):570-82. Kirkpatrick CA, Knox SM, Staatz WD, Fox B, Lercher DM, Selleck SB. PMID: 17055473.
        View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
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