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Sarah Knox, PhD

Title(s)Associate Professor, Cell and Tissue Biology
SchoolSchool of Dentistry
Phone415-502-0811
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    Collapse Biography 
    Collapse Education and Training
    NIDCRPost-doctoral Fellow2011Laboratory of Cell and Developmental Biology
    University of NSWPhD2002Biomedical Engineering

    Collapse Research 
    Collapse Research Activities and Funding
    2018 Salivary Glands and Exocrine Biology Gordon Research Conference and Seminar
    NIH/NIDCR R13DE028494Feb 1, 2019 - Jan 31, 2020
    Role: Principal Investigator
    Defining mechanisms driving salivary gland regeneration
    NIH/NIDCR R35DE028255Sep 18, 2018 - Jun 30, 2026
    Role: Principal Investigator
    Autonomic regulation of lacrimal stem cells
    NIH/NEI R01EY027392Sep 30, 2017 - Jun 30, 2020
    Role: Principal Investigator
    Defining the role of immune-neuronal crosstalk in dry eye disease
    NIH/NEI R01EY026492Sep 30, 2016 - Jul 31, 2019
    Role: Principal Investigator
    2016 Proteoglycans Gordon Research Conference & Gordon Research Seminar
    NIH/NIAMS R13AR069957May 1, 2016 - Apr 30, 2017
    Role: Principal Investigator
    Impact of aging on salivary stem cells and organ regeneration
    NIH/NIDCR R21DE025736Apr 1, 2016 - Mar 31, 2018
    Role: Principal Investigator
    Defining the role of the nervous system in aqueous-deficient dry eye
    NIH/NEI R01EY025980Aug 1, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Neuronal regulation of salivary stem cells
    NIH/NIDCR R01DE024188Apr 1, 2014 - Dec 31, 2018
    Role: Principal Investigator
    Salivary gland repair and regeneration via Schwann cell-nerve interactions
    NIH/NIDCR R21DE022951Jul 20, 2012 - Jun 30, 2014
    Role: Principal Investigator
    Neuronal-epithelial interactions that regulate mouse salivary gland development
    NIH/NIDCR R00DE018969Jan 24, 2012 - Dec 31, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Featured Presentations

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sudiwala S, Knox SM. The Emerging Role of Cranial Nerves in Shaping Craniofacial Development. Genesis. 2019 Jan 09; e23282. PMID: 30628162.
      View in: PubMed
    2. Chen FY, Gaylord E, McNamara N, Knox S. Deciphering Molecular and Phenotypic Changes Associated with Early Autoimmune Disease in the Aire-Deficient Mouse Model of Sjögren's Syndrome. Int J Mol Sci. 2018 Nov 17; 19(11). PMID: 30453645.
      View in: PubMed
    3. May AJ, Cruz-Pacheco N, Emmerson E, Gaylord EA, Seidel K, Nathan S, Muench MO, Klein OD, Knox SM. Diverse progenitor cells preserve salivary gland ductal architecture after radiation-induced damage. Development. 2018 Nov 05; 145(21). PMID: 30305288.
      View in: PubMed
    4. Byrnes LE, Wong DM, Subramaniam M, Meyer NP, Gilchrist CL, Knox SM, Tward AD, Ye CJ, Sneddon JB. Lineage dynamics of murine pancreatic development at single-cell resolution. Nat Commun. 2018 09 25; 9(1):3922. PMID: 30254276.
      View in: PubMed
    5. Saiki JP, Cao H, Van Wassenhove LD, Viswanathan V, Bloomstein J, Nambiar DK, Mattingly AJ, Jiang D, Chen CH, Stevens MC, Simmons AL, Park HS, von Eyben R, Kool ET, Sirjani D, Knox SM, Le QT, Mochly-Rosen D. Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes. Proc Natl Acad Sci U S A. 2018 06 12; 115(24):6279-6284. PMID: 29794221.
      View in: PubMed
    6. Emmerson E, Knox SM. Salivary gland stem cells: A review of development, regeneration and cancer. Genesis. 2018 05; 56(5):e23211. PMID: 29663717.
      View in: PubMed
    7. Emmerson E, May AJ, Berthoin L, Cruz-Pacheco N, Nathan S, Mattingly AJ, Chang JL, Ryan WR, Tward AD, Knox SM. Salivary glands regenerate after radiation injury through SOX2-mediated secretory cell replacement. EMBO Mol Med. 2018 03; 10(3). PMID: 29335337.
      View in: PubMed
    8. Chen FY, Lee A, Ge S, Nathan S, Knox SM, McNamara NA. Aire-deficient mice provide a model of corneal and lacrimal gland neuropathy in Sjögren's syndrome. PLoS One. 2017; 12(9):e0184916. PMID: 28926640.
      View in: PubMed
    9. Emmerson E, May AJ, Nathan S, Cruz-Pacheco N, Lizama CO, Maliskova L, Zovein AC, Shen Y, Muench MO, Knox SM. SOX2 regulates acinar cell development in the salivary gland. Elife. 2017 06 17; 6. PMID: 28623666.
      View in: PubMed
    10. Togarrati PP, Sasaki RT, Abdel-Mohsen M, Dinglasan N, Deng X, Desai S, Emmerson E, Yee E, Ryan WR, da Silva MCP, Knox SM, Pillai SK, Muench MO. Identification and characterization of a rich population of CD34+ mesenchymal stem/stromal cells in human parotid, sublingual and submandibular glands. Sci Rep. 2017 06 14; 7(1):3484. PMID: 28615711.
      View in: PubMed
    11. Farmer DT, Nathan S, Finley JK, Shengyang Yu K, Emmerson E, Byrnes LE, Sneddon JB, McManus MT, Tward AD, Knox SM. Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland. Development. 2017 07 01; 144(13):2517-2528. PMID: 28576768.
      View in: PubMed
    12. Farmer DT, Finley JK, Chen FY, Tarifeño-Saldivia E, McNamara NA, Knox SM, McManus MT. miR-205 is a critical regulator of lacrimal gland development. Dev Biol. 2017 07 01; 427(1):12-20. PMID: 28511845.
      View in: PubMed
    13. Mattingly A, Finley JK, Knox SM. Salivary gland development and disease. Wiley Interdiscip Rev Dev Biol. 2015 Nov-Dec; 4(6):573-90. PMID: 25970268.
      View in: PubMed
    14. Knosp WM, Knox SM, Lombaert IM, Haddox CL, Patel VN, Hoffman MP. Submandibular parasympathetic gangliogenesis requires sprouty-dependent Wnt signals from epithelial progenitors. Dev Cell. 2015 Mar 23; 32(6):667-77. PMID: 25805134.
      View in: PubMed
    15. Finley JK, Farmer D, Emmerson E, Cruz Pacheco N, Knox SM. Manipulating the murine lacrimal gland. J Vis Exp. 2014 Nov 18; (93):e51970. PMID: 25490187.
      View in: PubMed
    16. Nedvetsky PI, Emmerson E, Finley JK, Ettinger A, Cruz-Pacheco N, Prochazka J, Haddox CL, Northrup E, Hodges C, Mostov KE, Hoffman MP, Knox SM. Parasympathetic innervation regulates tubulogenesis in the developing salivary gland. Dev Cell. 2014 Aug 25; 30(4):449-62. PMID: 25158854; PMCID: PMC4155578.
    17. Knox SM, Lombaert IM, Haddox CL, Abrams SR, Cotrim A, Wilson AJ, Hoffman MP. Parasympathetic stimulation improves epithelial organ regeneration. Nat Commun. 2013; 4:1494. PMID: 23422662.
      View in: PubMed
    18. Knosp WM, Knox SM, Hoffman MP. Salivary gland organogenesis. Wiley Interdiscip Rev Dev Biol. 2012 Jan-Feb; 1(1):69-82. PMID: 23801668.
      View in: PubMed
    19. Chuang CY, Lord MS, Melrose J, Rees MD, Knox SM, Freeman C, Iozzo RV, Whitelock JM. Heparan sulfate-dependent signaling of fibroblast growth factor 18 by chondrocyte-derived perlecan. Biochemistry. 2010 Jul 06; 49(26):5524-32. PMID: 20507176.
      View in: PubMed
    20. Patel VN, Knox SM, Likar KM, Lathrop CA, Hossain R, Eftekhari S, Whitelock JM, Elkin M, Vlodavsky I, Hoffman MP. Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. Development. 2007 Dec; 134(23):4177-86. PMID: 17959718.
      View in: PubMed
    21. Knox S, Ge H, Dimitroff BD, Ren Y, Howe KA, Arsham AM, Easterday MC, Neufeld TP, O'Connor MB, Selleck SB. Mechanisms of TSC-mediated control of synapse assembly and axon guidance. PLoS One. 2007 Apr 18; 2(4):e375. PMID: 17440611; PMCID: PMC1847706.
    22. Melrose J, Roughley P, Knox S, Smith S, Lord M, Whitelock J. The structure, location, and function of perlecan, a prominent pericellular proteoglycan of fetal, postnatal, and mature hyaline cartilages. J Biol Chem. 2006 Dec 01; 281(48):36905-14. PMID: 16984910.
      View in: PubMed
    23. Kirkpatrick CA, Knox SM, Staatz WD, Fox B, Lercher DM, Selleck SB. The function of a Drosophila glypican does not depend entirely on heparan sulfate modification. Dev Biol. 2006 Dec 15; 300(2):570-82. PMID: 17055473.
      View in: PubMed
    24. Di Giusto DA, Knox SM, Lai Y, Tyrelle GD, Aung MT, King GC. Multitasking by multivalent circular DNA aptamers. Chembiochem. 2006 Mar; 7(3):535-44. PMID: 16482500.
      View in: PubMed
    25. Melrose J, Smith S, Knox S, Whitelock J. Perlecan, the multidomain HS-proteoglycan of basement membranes, is a prominent pericellular component of ovine hypertrophic vertebral growth plate and cartilaginous endplate chondrocytes. Histochem Cell Biol. 2002 Oct; 118(4):269-80. PMID: 12376823.
      View in: PubMed
    26. Knox S, Merry C, Stringer S, Melrose J, Whitelock J. Not all perlecans are created equal: interactions with fibroblast growth factor (FGF) 2 and FGF receptors. J Biol Chem. 2002 Apr 26; 277(17):14657-65. PMID: 11847221.
      View in: PubMed