Diana Laird, PhD

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentOb/Gyn, Reproductive Sciences
Address35 Medical Center Way
San Francisco CA 94143
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    Collapse Biography 
    Collapse Education and Training
    Harvard UniversityA.B.1995Physics
    Stanford UniversityPh.D.2003Biological Sciences
    Sloan Kettering InstitutePostdoctoral Fellowship2007Developmental Biology

    Collapse Overview 
    Collapse Overview
    Our research focuses on the development of germ cells in mammalian embryos. We are working toward understanding the causes of infertility, enhancing our understanding of the fundamental process of gamete selection in evolution, and unlocking the potential of stem cells to generate gametes for research, human reproduction and agriculture.

    Collapse Research 
    Collapse Research Activities and Funding
    The intersection of stress and environmental chemicals in germ cell reprogramming
    NIH/NIEHS R01ES028212Sep 15, 2017 - Aug 31, 2022
    Role: Principal Investigator
    The 2014 Santa Cruz Developmental Biology Meeting
    NIH/NICHD R13HD081860Jul 15, 2014 - Jun 30, 2015
    Role: Principal Investigator
    Assessing transgenerational effects of Phthalates on primordial germ cells
    NIH/NIEHS R21ES023297Aug 29, 2013 - Jul 31, 2016
    Role: Principal Investigator
    Cell competition in the developing mouse germline
    NIH DP2OD007420Sep 30, 2010 - Jun 30, 2015
    Role: Principal Investigator

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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Susman MW, Karuna EP, Kunz RC, Gujral TS, Cantú AV, Choi SS, Jong BY, Okada K, Scales MK, Hum J, Hu LS, Kirschner MW, Nishinakamura R, Yamada S, Laird D, Jao LE, Gygi SP, Greenberg ME, Ho HH. Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates. Elife. 2017 Sep 08; 6. PMID: 28885975.
      View in: PubMed
    2. Cantú AV, Laird D. A pilgrim's progress: Seeking meaning in primordial germ cell migration. Stem Cell Res. 2017 Jul 18. PMID: 28754603.
      View in: PubMed
    3. Whitaker AT, Berthet E, Cantu A, Laird D, Alliston T. Smad4 regulates growth plate matrix production and chondrocyte polarity. Biol Open. 2017 Mar 15; 6(3):358-364. PMID: 28167493.
      View in: PubMed
    4. Curtis A, Li DJ, DeVeale B, Onishi K, Kim MY, Blelloch R, Laird D, Hui EE. Patterning of sharp cellular interfaces with a reconfigurable elastic substrate. Integr Biol (Camb). 2017 Jan 23; 9(1):50-57. PMID: 28001149.
      View in: PubMed
    5. Arora R, Fries A, Oelerich K, Marchuk K, Sabeur K, Giudice LC, Laird D. Insights from imaging the implanting embryo and the uterine environment in three dimensions. Development. 2016 Dec 15; 143(24):4749-4754. PMID: 27836961.
      View in: PubMed
    6. Cantú AV, Altshuler-Keylin S, Laird D, et al. Discrete somatic niches coordinate proliferation and migration of primordial germ cells via Wnt signaling. J Cell Biol. 2016 Jul 18; 214(2):215-29. PMID: 27402951; PMCID: PMC4949447 [Available on 01/18/17].
    7. Arora R, Abby E, Ross AD, Cantu AV, Kissner MD, Castro V, Ho HY, Livera G, Laird D. Meiotic onset is reliant on spatial distribution but independent of germ cell number in the mouse ovary. J Cell Sci. 2016 Jul 01; 129(13):2493-9. PMID: 27199373.
      View in: PubMed
    8. Tran ND, Kissner M, Subramanyam D, Parchem RJ, Laird D, Blelloch RH. A miR-372/let-7 Axis Regulates Human Germ Versus Somatic Cell Fates. Stem Cells. 2016 Jul; 34(7):1985-91. PMID: 27066911.
      View in: PubMed
    9. Martins JP, Liu X, Oke A, Arora R, Franciosi F, Viville S, Laird D, Fung JC, Conti M. DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation. J Cell Sci. 2016 Mar 15; 129(6):1271-82. PMID: 26826184; PMCID: PMC4813292 [Available on 03/15/17].
    10. Chen JC, Hoffman JR, Arora R, Perrone LA, Gonzalez-Gomez CJ, Vo KC, Laird D, Irwin JC, Giudice LC. Cryopreservation and recovery of human endometrial epithelial cells with high viability, purity, and functional fidelity. Fertil Steril. 2016 Feb; 105(2):501-10.e1. PMID: 26515378; PMCID: PMC4744114 [Available on 02/01/17].
    11. Faire M, Skillern A, Arora R, Nguyen DH, Wang J, Chamberlain C, German MS, Fung JC, Laird D. Follicle dynamics and global organization in the intact mouse ovary. Dev Biol. 2015 Jul 01; 403(1):69-79. PMID: 25889274; PMCID: PMC4469539.
    12. Arora R, Altman E, Tran ND, Laird D. Novel domains of expression for orphan receptor tyrosine kinase Ror2 in the human and mouse reproductive system. Dev Dyn. 2014 Aug; 243(8):1037-45. PMID: 24753105; PMCID: PMC4258601.
    13. Cantú AV, Laird D. Wnt and Bmp fit germ cells to a T. Dev Cell. 2013 Dec 09; 27(5):485-7. PMID: 24331924; PMCID: PMC3929049.
    14. Blaschke K, Ebata KT, Karimi MM, Zepeda-Martínez JA, Goyal P, Mahapatra S, Tam A, Laird D, Hirst M, Rao A, Lorincz MC, Ramalho-Santos M. Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature. 2013 Aug 08; 500(7461):222-6. PMID: 23812591; PMCID: PMC3893718.
    15. Laird D. Humans put their eggs in more than one basket. Nat Cell Biol. 2013 Jan; 15(1):13-5. PMID: 23263370; PMCID: PMC3889477.
    16. Chen L, Faire M, Kissner MD, Laird D. Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele. Hum Mol Genet. 2013 Jan 15; 22(2):313-27. PMID: 23077213; PMCID: PMC3526162.
    17. Laird D, Altshuler-Keylin S, Kissner MD, Zhou X, Anderson KV. Ror2 enhances polarity and directional migration of primordial germ cells. PLoS Genet. 2011 Dec; 7(12):e1002428. PMID: 22216013; PMCID: PMC3245308.
    18. Espejel S, Roll GR, McLaughlin KJ, Lee AY, Zhang JY, Laird D, Okita K, Yamanaka S, Willenbring H. Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice. J Clin Invest. 2010 Sep; 120(9):3120-6. PMID: 20739754; PMCID: PMC2929736.
    19. Laird D, von Andrian UH, Wagers AJ. Stem cell trafficking in tissue development, growth, and disease. Cell. 2008 Feb 22; 132(4):612-30. PMID: 18295579.
      View in: PubMed
    20. Laird D, De Tomaso AW, Weissman IL. Stem cells are units of natural selection in a colonial ascidian. Cell. 2005 Dec 29; 123(7):1351-60. PMID: 16377573.
      View in: PubMed
    21. Laird D, Chang WT, Weissman IL, Lauzon RJ. Identification of a novel gene involved in asexual organogenesis in the budding ascidian Botryllus schlosseri. Dev Dyn. 2005 Dec; 234(4):997-1005. PMID: 16193502; PMCID: PMC2821222.
    22. Laird D, De Tomaso AW. Predatory stem cells in the non-zebrafish chordate, Botryllus schlosseri. Zebrafish. 2005; 1(4):357-61. PMID: 18248214.
      View in: PubMed
    23. Laird D, Weissman IL. Telomerase maintained in self-renewing tissues during serial regeneration of the urochordate Botryllus schlosseri. Dev Biol. 2004 Sep 15; 273(2):185-94. PMID: 15328006.
      View in: PubMed
    24. Laird D, Weissman IL. Continuous development precludes radioprotection in a colonial ascidian. Dev Comp Immunol. 2004 Mar; 28(3):201-9. PMID: 14642887.
      View in: PubMed
    25. Laird D, De Tomaso AW, Cooper MD, Weissman IL. 50 million years of chordate evolution: seeking the origins of adaptive immunity. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):6924-6. PMID: 10860947; PMCID: PMC34360.
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