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Diana Laird, PhD

Title(s)Associate Professor, Ob/Gyn, Reproductive Sciences
SchoolSchool of Medicine
Phone415-476-5471
ORCID ORCID Icon0000-0002-4930-0560 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Harvard UniversityA.B.1995Physics
    Stanford UniversityPh.D.2003Biological Sciences
    Sloan Kettering InstitutePostdoctoral Fellowship2007Developmental Biology

    Collapse Overview 
    Collapse Overview
    Our work focuses on three interrelated questions: do all developing germ cells have equal potential to give rise to functional eggs or sperm; how do environmental inputs affect germ cells during development, and what is the role of germ cells in ovarian and systemic aging? Using mouse models, human cells, and naked mole rats, we explore these questions in the real-world contexts of prenatal exposures to endocrine-disrupting chemicals and psychosocial stress as well as genetic causes of infertility such as Fragile X Primary Ovarian Insufficiency. Our work spans the fields of epigenetics, developmental and stem cell biology. As a federally-funded lab in a public university, our broad mission is to advance knowledge toward improving human health, provide research training for students and postdoctoral fellows, and promote public awareness of science.

    Collapse Research 
    Collapse Research Activities and Funding
    Fmr1 Function and Repeat Expansion in the Developing Germline
    NIH/NIGMS R01GM122902Dec 26, 2017 - Nov 30, 2021
    Role: Principal Investigator
    The intersection of stress and environmental chemicals in germ cell reprogramming
    NIH/NIEHS R01ES028212Sep 15, 2017 - Aug 31, 2022
    Role: Principal Investigator
    The 2014 Santa Cruz Developmental Biology Meeting
    NIH/NICHD R13HD081860Jul 15, 2014 - Jun 30, 2015
    Role: Principal Investigator
    Assessing transgenerational effects of Phthalates on primordial germ cells
    NIH/NIEHS R21ES023297Aug 29, 2013 - Jul 31, 2016
    Role: Principal Investigator
    Cell competition in the developing mouse germline
    NIH DP2OD007420Sep 30, 2010 - Jun 30, 2015
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
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    Collapse In The News
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Wall E, Scoles J, Joo A, Klein O, Quinonez C, Bush JO, Martin GR, Laird DJ. The UCSF Mouse Inventory Database Application, an Open Source Web App for Sharing Mutant Mice within a Research Community. G3 (Bethesda). 2020 Mar 09. PMID: 32152007.
      View in: PubMed
    2. DiTroia SP, Percharde M, Guerquin MJ, Wall E, Collignon E, Ebata KT, Mesh K, Mahesula S, Agathocleous M, Laird DJ, Livera G, Ramalho-Santos M. Maternal vitamin C regulates reprogramming of DNA methylation and germline development. Nature. 2019 09; 573(7773):271-275. PMID: 31485074.
      View in: PubMed
    3. Nguyen DH, Jaszczak RG, Laird DJ. Heterogeneity of primordial germ cells. Curr Top Dev Biol. 2019; 135:155-201. PMID: 31155358.
      View in: PubMed
    4. Reznik B, Cincotta SA, Jaszczak RG, Mateo LJ, Shen J, Cao M, Baskin L, Ye P, An W, Laird DJ. Heterogeneity of transposon expression and activation of the repressive network in human fetal germ cells. Development. 2019 Feb 01; 146(12). PMID: 30658985.
      View in: PubMed
    5. Laird DJ. How to lose your inheritance. Nature. 2018 10; 562(7728):497-498. PMID: 30349122.
      View in: PubMed
    6. Susman MW, Karuna EP, Kunz RC, Gujral TS, Cantú AV, Choi SS, Jong BY, Okada K, Scales MK, Hum J, Hu LS, Kirschner MW, Nishinakamura R, Yamada S, Laird DJ, Jao LE, Gygi SP, Greenberg ME, Ho HH. Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates. Elife. 2017 09 08; 6. PMID: 28885975.
      View in: PubMed
    7. Cantú AV, Laird DJ. A pilgrim's progress: Seeking meaning in primordial germ cell migration. Stem Cell Res. 2017 10; 24:181-187. PMID: 28754603.
      View in: PubMed
    8. Whitaker AT, Berthet E, Cantu A, Laird DJ, Alliston T. Smad4 regulates growth plate matrix production and chondrocyte polarity. Biol Open. 2017 Mar 15; 6(3):358-364. PMID: 28167493.
      View in: PubMed
    9. Curtis A, Li DJ, DeVeale B, Onishi K, Kim MY, Blelloch R, Laird DJ, Hui EE. Patterning of sharp cellular interfaces with a reconfigurable elastic substrate. Integr Biol (Camb). 2017 01 23; 9(1):50-57. PMID: 28001149.
      View in: PubMed
    10. Arora R, Fries A, Oelerich K, Marchuk K, Sabeur K, Giudice LC, Laird DJ. Insights from imaging the implanting embryo and the uterine environment in three dimensions. Development. 2016 12 15; 143(24):4749-4754. PMID: 27836961.
      View in: PubMed
    11. Arora R, Laird DJ. ROR2 in the adult mouse testis. Mol Reprod Dev. 2016 11; 83(11):943. PMID: 27696582.
      View in: PubMed
    12. Cantú AV, Altshuler-Keylin S, Laird DJ. Discrete somatic niches coordinate proliferation and migration of primordial germ cells via Wnt signaling. J Cell Biol. 2016 07 18; 214(2):215-29. PMID: 27402951.
      View in: PubMed
    13. Arora R, Abby E, Ross AD, Cantu AV, Kissner MD, Castro V, Ho HY, Livera G, Laird DJ. Meiotic onset is reliant on spatial distribution but independent of germ cell number in the mouse ovary. J Cell Sci. 2016 07 01; 129(13):2493-9. PMID: 27199373.
      View in: PubMed
    14. Tran ND, Kissner M, Subramanyam D, Parchem RJ, Laird DJ, Blelloch RH. A miR-372/let-7 Axis Regulates Human Germ Versus Somatic Cell Fates. Stem Cells. 2016 07; 34(7):1985-91. PMID: 27066911.
      View in: PubMed
    15. Sousa Martins JP, Liu X, Oke A, Arora R, Franciosi F, Viville S, Laird DJ, Fung JC, Conti M. DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation. J Cell Sci. 2016 Mar 15; 129(6):1271-82. PMID: 26826184.
      View in: PubMed
    16. Chen JC, Hoffman JR, Arora R, Perrone LA, Gonzalez-Gomez CJ, Vo KC, Laird DJ, Irwin JC, Giudice LC. Cryopreservation and recovery of human endometrial epithelial cells with high viability, purity, and functional fidelity. Fertil Steril. 2016 Feb; 105(2):501-10.e1. PMID: 26515378.
      View in: PubMed
    17. Faire M, Skillern A, Arora R, Nguyen DH, Wang J, Chamberlain C, German MS, Fung JC, Laird DJ. Follicle dynamics and global organization in the intact mouse ovary. Dev Biol. 2015 Jul 01; 403(1):69-79. PMID: 25889274.
      View in: PubMed
    18. Arora R, Altman E, Tran ND, Laird DJ. Novel domains of expression for orphan receptor tyrosine kinase Ror2 in the human and mouse reproductive system. Dev Dyn. 2014 Aug; 243(8):1037-45. PMID: 24753105.
      View in: PubMed
    19. Cantú AV, Laird DJ. Wnt and Bmp fit germ cells to a T. Dev Cell. 2013 Dec 09; 27(5):485-7. PMID: 24331924.
      View in: PubMed
    20. Blaschke K, Ebata KT, Karimi MM, Zepeda-Martínez JA, Goyal P, Mahapatra S, Tam A, Laird DJ, Hirst M, Rao A, Lorincz MC, Ramalho-Santos M. Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature. 2013 Aug 08; 500(7461):222-6. PMID: 23812591.
      View in: PubMed
    21. Laird DJ. Humans put their eggs in more than one basket. Nat Cell Biol. 2013 Jan; 15(1):13-5. PMID: 23263370.
      View in: PubMed
    22. Chen L, Faire M, Kissner MD, Laird DJ. Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele. Hum Mol Genet. 2013 Jan 15; 22(2):313-27. PMID: 23077213.
      View in: PubMed
    23. N.D. Tran, M. Kissner, D. Laird, R. Blelloch. miR-372/let-7 axis regulates human primordial germ cell specification. Fertility and Sterility. 2012 Sep 1; 98(3):s19.
      View in: Publisher Site
    24. Laird DJ, Altshuler-Keylin S, Kissner MD, Zhou X, Anderson KV. Ror2 enhances polarity and directional migration of primordial germ cells. PLoS Genet. 2011 Dec; 7(12):e1002428. PMID: 22216013.
      View in: PubMed
    25. N.D. Tran, D. Laird, M. Kissner, M. Conti, R. Blelloch. Lin28-let7-Blimp1 Circuitry regulates human primordial germ cells (hPGC) development from human embryonic stem cells (hESC). Fertility and Sterility. 2011 Sep 1; 96(3):s104.
      View in: Publisher Site
    26. N.D. Tran, D. Laird, M. Kissner, D. Supramanyam, M. Conti, R. Blelloch. Establishment and characterization of human germ cells derived from embryonic stem cells (hESCs). Fertility and Sterility. 2010 Sep 1; 94(4):s7-s8.
      View in: Publisher Site
    27. Espejel S, Roll GR, McLaughlin KJ, Lee AY, Zhang JY, Laird DJ, Okita K, Yamanaka S, Willenbring H. Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice. J Clin Invest. 2010 Sep; 120(9):3120-6. PMID: 20739754.
      View in: PubMed
    28. Laird DJ, von Andrian UH, Wagers AJ. Stem cell trafficking in tissue development, growth, and disease. Cell. 2008 Feb 22; 132(4):612-30. PMID: 18295579.
      View in: PubMed
    29. Laird DJ, De Tomaso AW, Weissman IL. Stem cells are units of natural selection in a colonial ascidian. Cell. 2005 Dec 29; 123(7):1351-60. PMID: 16377573.
      View in: PubMed
    30. Laird DJ, Chang WT, Weissman IL, Lauzon RJ. Identification of a novel gene involved in asexual organogenesis in the budding ascidian Botryllus schlosseri. Dev Dyn. 2005 Dec; 234(4):997-1005. PMID: 16193502.
      View in: PubMed
    31. Laird DJ, De Tomaso AW. Predatory stem cells in the non-zebrafish chordate, Botryllus schlosseri. Zebrafish. 2005; 1(4):357-61. PMID: 18248214.
      View in: PubMed
    32. Laird DJ, Weissman IL. Telomerase maintained in self-renewing tissues during serial regeneration of the urochordate Botryllus schlosseri. Dev Biol. 2004 Sep 15; 273(2):185-94. PMID: 15328006.
      View in: PubMed
    33. Laird DJ, Weissman IL. Continuous development precludes radioprotection in a colonial ascidian. Dev Comp Immunol. 2004 Mar; 28(3):201-9. PMID: 14642887.
      View in: PubMed
    34. Laird DJ, De Tomaso AW, Cooper MD, Weissman IL. 50 million years of chordate evolution: seeking the origins of adaptive immunity. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):6924-6. PMID: 10860947.
      View in: PubMed
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