Diana Laird, PhD
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Title(s) | Associate Professor, Ob/Gyn, Reproductive Sciences |
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School | School of Medicine |
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Address | 35 Medical Center Way San Francisco CA 94143
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Phone | 415-476-5471 |
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ORCID
.gif) | 0000-0002-4930-0560  |
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vCard | Download vCard |
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Biography Harvard University | A.B. | 1995 | Physics | Stanford University | Ph.D. | 2003 | Biological Sciences | Sloan Kettering Institute | Postdoctoral Fellowship | 2007 | Developmental Biology |
Overview Our work focuses on three interrelated questions: do all developing germ cells have equal potential to give rise to functional eggs or sperm; how do environmental inputs affect germ cells during development, and what is the role of germ cells in ovarian and systemic aging? Using mouse models, human cells, and naked mole rats, we explore these questions in the real-world contexts of prenatal exposures to endocrine-disrupting chemicals and psychosocial stress as well as genetic causes of infertility such as Fragile X Primary Ovarian Insufficiency. Our work spans the fields of epigenetics, developmental and stem cell biology. As a federally-funded lab in a public university, our broad mission is to advance knowledge toward improving human health, provide research training for students and postdoctoral fellows, and promote public awareness of science.
Research ORNG Applications Bibliographic
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
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Apoptosis in the fetal testis eliminates developmentally defective germ cell clones. Nat Cell Biol. 2020 Dec; 22(12):1423-1435.
Nguyen DH, Soygur B, Peng SP, Malki S, Hu G, Laird DJ. PMID: 33199844.
View in: PubMed Mentions: 1 Fields:
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MON-LB130 Glucocorticoid Receptor Signaling and Stress in the Developing Mammalian Germline. Journal of the Endocrine Society. 2020 May 8; 4(Suppl 1).
Steven Anthony Cincotta, Diana Laird. .
View in: Publisher Site Mentions:
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The UCSF Mouse Inventory Database Application, an Open Source Web App for Sharing Mutant Mice Within a Research Community. G3 (Bethesda). 2020 05 04; 10(5):1503-1510.
Wall E, Scoles J, Joo A, Klein O, Quinonez C, Bush JO, Martin GR, Laird DJ. PMID: 32152007.
View in: PubMed Mentions: Fields:
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Maternal vitamin C regulates reprogramming of DNA methylation and germline development. Nature. 2019 09; 573(7773):271-275.
DiTroia SP, Percharde M, Guerquin MJ, Wall E, Collignon E, Ebata KT, Mesh K, Mahesula S, Agathocleous M, Laird DJ, Livera G, Ramalho-Santos M. PMID: 31485074.
View in: PubMed Mentions: 11 Fields: Translation: AnimalsCells
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Heterogeneity of primordial germ cells. Curr Top Dev Biol. 2019; 135:155-201.
Nguyen DH, Jaszczak RG, Laird DJ. PMID: 31155358.
View in: PubMed Mentions: Fields: Translation: AnimalsCells
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Heterogeneity of transposon expression and activation of the repressive network in human fetal germ cells. Development. 2019 02 01; 146(12).
Reznik B, Cincotta SA, Jaszczak RG, Mateo LJ, Shen J, Cao M, Baskin L, Ye P, An W, Laird DJ. PMID: 30658985.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimalsCells
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How to lose your inheritance. Nature. 2018 10; 562(7728):497-498.
Laird DJ. PMID: 30349122.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
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Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates. Elife. 2017 09 08; 6.
Susman MW, Karuna EP, Kunz RC, Gujral TS, Cantú AV, Choi SS, Jong BY, Okada K, Scales MK, Hum J, Hu LS, Kirschner MW, Nishinakamura R, Yamada S, Laird DJ, Jao LE, Gygi SP, Greenberg ME, Ho HH. PMID: 28885975.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimalsCells
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A pilgrim's progress: Seeking meaning in primordial germ cell migration. Stem Cell Res. 2017 10; 24:181-187.
Cantú AV, Laird DJ. PMID: 28754603.
View in: PubMed Mentions: 2 Fields: Translation: AnimalsCells
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Smad4 regulates growth plate matrix production and chondrocyte polarity. Biol Open. 2017 Mar 15; 6(3):358-364.
Whitaker AT, Berthet E, Cantu A, Laird DJ, Alliston T. PMID: 28167493.
View in: PubMed Mentions:
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Patterning of sharp cellular interfaces with a reconfigurable elastic substrate. Integr Biol (Camb). 2017 01 23; 9(1):50-57.
Curtis A, Li DJ, DeVeale B, Onishi K, Kim MY, Blelloch R, Laird DJ, Hui EE. PMID: 28001149.
View in: PubMed Mentions: 2 Fields: Translation: AnimalsCells
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Insights from imaging the implanting embryo and the uterine environment in three dimensions. Development. 2016 12 15; 143(24):4749-4754.
Arora R, Fries A, Oelerich K, Marchuk K, Sabeur K, Giudice LC, Laird DJ. PMID: 27836961.
View in: PubMed Mentions: 10 Fields: Translation: HumansAnimals
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ROR2 in the adult mouse testis. Mol Reprod Dev. 2016 11; 83(11):943.
Arora R, Laird DJ. PMID: 27696582.
View in: PubMed Mentions: Fields:
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Discrete somatic niches coordinate proliferation and migration of primordial germ cells via Wnt signaling. J Cell Biol. 2016 07 18; 214(2):215-29.
Cantú AV, Altshuler-Keylin S, Laird DJ. PMID: 27402951.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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Meiotic onset is reliant on spatial distribution but independent of germ cell number in the mouse ovary. J Cell Sci. 2016 07 01; 129(13):2493-9.
Arora R, Abby E, Ross AD, Cantu AV, Kissner MD, Castro V, Ho HY, Livera G, Laird DJ. PMID: 27199373.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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A miR-372/let-7 Axis Regulates Human Germ Versus Somatic Cell Fates. Stem Cells. 2016 07; 34(7):1985-91.
Tran ND, Kissner M, Subramanyam D, Parchem RJ, Laird DJ, Blelloch RH. PMID: 27066911.
View in: PubMed Mentions: 8 Fields: Translation: HumansCells
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DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation. J Cell Sci. 2016 Mar 15; 129(6):1271-82.
Sousa Martins JP, Liu X, Oke A, Arora R, Franciosi F, Viville S, Laird DJ, Fung JC, Conti M. PMID: 26826184.
View in: PubMed Mentions: 25 Fields: Translation: AnimalsCells
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Cryopreservation and recovery of human endometrial epithelial cells with high viability, purity, and functional fidelity. Fertil Steril. 2016 Feb; 105(2):501-10.e1.
Chen JC, Hoffman JR, Arora R, Perrone LA, Gonzalez-Gomez CJ, Vo KC, Laird DJ, Irwin JC, Giudice LC. PMID: 26515378.
View in: PubMed Mentions: 3 Fields: Translation: HumansCells
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Follicle dynamics and global organization in the intact mouse ovary. Dev Biol. 2015 Jul 01; 403(1):69-79.
Faire M, Skillern A, Arora R, Nguyen DH, Wang J, Chamberlain C, German MS, Fung JC, Laird DJ. PMID: 25889274.
View in: PubMed Mentions: 12 Fields: Translation: AnimalsCells
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Novel domains of expression for orphan receptor tyrosine kinase Ror2 in the human and mouse reproductive system. Dev Dyn. 2014 Aug; 243(8):1037-45.
Arora R, Altman E, Tran ND, Laird DJ. PMID: 24753105.
View in: PubMed Mentions: 3 Fields: Translation: HumansAnimalsCells
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Wnt and Bmp fit germ cells to a T. Dev Cell. 2013 Dec 09; 27(5):485-7.
PMID: 24331924.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature. 2013 Aug 08; 500(7461):222-6.
PMID: 23812591.
View in: PubMed Mentions: 256 Fields: Translation: AnimalsCells
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Humans put their eggs in more than one basket. Nat Cell Biol. 2013 Jan; 15(1):13-5.
PMID: 23263370.
View in: PubMed Mentions: 2 Fields: Translation: HumansCells
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Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele. Hum Mol Genet. 2013 Jan 15; 22(2):313-27.
PMID: 23077213.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
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miR-372/let-7 axis regulates human primordial germ cell specification. Fertility and Sterility. 2012 Sep 1; 98(3):s19.
N.D. Tran, M. Kissner, D. Laird, R. Blelloch. .
View in: Publisher Site Mentions:
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Ror2 enhances polarity and directional migration of primordial germ cells. PLoS Genet. 2011 Dec; 7(12):e1002428.
PMID: 22216013.
View in: PubMed Mentions: 27 Fields: Translation: AnimalsCells
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Lin28-let7-Blimp1 Circuitry regulates human primordial germ cells (hPGC) development from human embryonic stem cells (hESC). Fertility and Sterility. 2011 Sep 1; 96(3):s104.
N.D. Tran, D. Laird, M. Kissner, M. Conti, R. Blelloch. .
View in: Publisher Site Mentions:
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Establishment and characterization of human germ cells derived from embryonic stem cells (hESCs). Fertility and Sterility. 2010 Sep 1; 94(4):s7-s8.
N.D. Tran, D. Laird, M. Kissner, D. Supramanyam, M. Conti, R. Blelloch. .
View in: Publisher Site Mentions:
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Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice. J Clin Invest. 2010 Sep; 120(9):3120-6.
Espejel S, Roll GR, McLaughlin KJ, Lee AY, Zhang JY, Laird DJ, Okita K, Yamanaka S, Willenbring H. PMID: 20739754.
View in: PubMed Mentions: 59 Fields: Translation: AnimalsCells
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Stem cell trafficking in tissue development, growth, and disease. Cell. 2008 Feb 22; 132(4):612-30.
Laird DJ, von Andrian UH, Wagers AJ. PMID: 18295579.
View in: PubMed Mentions: 90 Fields: Translation: HumansAnimalsCells
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Stem cells are units of natural selection in a colonial ascidian. Cell. 2005 Dec 29; 123(7):1351-60.
Laird DJ, De Tomaso AW, Weissman IL. PMID: 16377573.
View in: PubMed Mentions: 50 Fields: Translation: AnimalsCells
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Identification of a novel gene involved in asexual organogenesis in the budding ascidian Botryllus schlosseri. Dev Dyn. 2005 Dec; 234(4):997-1005.
Laird DJ, Chang WT, Weissman IL, Lauzon RJ. PMID: 16193502.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
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Predatory stem cells in the non-zebrafish chordate, Botryllus schlosseri. Zebrafish. 2005; 1(4):357-61.
Laird DJ, De Tomaso AW. PMID: 18248214.
View in: PubMed Mentions: Fields:
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Telomerase maintained in self-renewing tissues during serial regeneration of the urochordate Botryllus schlosseri. Dev Biol. 2004 Sep 15; 273(2):185-94.
Laird DJ, Weissman IL. PMID: 15328006.
View in: PubMed Mentions: 10 Fields: Translation: AnimalsCells
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Continuous development precludes radioprotection in a colonial ascidian. Dev Comp Immunol. 2004 Mar; 28(3):201-9.
Laird DJ, Weissman IL. PMID: 14642887.
View in: PubMed Mentions: 1 Fields: Translation: Animals
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50 million years of chordate evolution: seeking the origins of adaptive immunity. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):6924-6.
Laird DJ, De Tomaso AW, Cooper MD, Weissman IL. PMID: 10860947.
View in: PubMed Mentions: 21 Fields: Translation: HumansAnimals
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Year | Publications |
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2000 | 1 | 2004 | 2 | 2005 | 3 | 2008 | 1 | 2010 | 2 | 2011 | 2 | 2012 | 2 | 2013 | 3 | 2014 | 1 | 2015 | 2 | 2016 | 6 | 2017 | 4 | 2018 | 1 | 2019 | 3 | 2020 | 3 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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