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Judy Sakanari, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentPharmaceutical Chemistry
Address1700 4th St
San Francisco CA 94158
Phone415-476-0825
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    Collapse Research 
    Collapse Research Activities and Funding
    Novel Therapeutics for Treatment of River Blindness and Lymphatic Filariasis
    NIH R21AI127639Dec 26, 2016 - Nov 30, 2018
    Role: Principal Investigator
    Developing a macrofilaricidal drug for onchocerciasis and lymphatic filariasis
    Bill & Melinda Gates Foundation Jul 1, 2014
    Role: Principal Investigator
    ASCARID SERINE PROTEASE INHIBITORS
    NIH/NIAID R21AI040703Sep 30, 1997 - Sep 29, 2000
    Role: Principal Investigator
    SERINE PROTEASE FROM ANISAKIS
    NIH/NIAID R29AI029457Feb 1, 1991 - Jan 31, 1997
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Tyagi R, Maddirala AR, Elfawal M, Fischer C, Bulman CA, Rosa BA, Gao X, Chugani R, Zhou M, Helander J, Brindley PJ, Tseng CC, Greig IR, Sakanari J, Wildman SA, Aroian R, Janetka JW, Mitreva M. Small Molecule Inhibitors of Metabolic Enzymes Repurposed as a New Class of Anthelmintics. ACS Infect Dis. 2018 May 14. PMID: 29718656.
      View in: PubMed
    2. Bulman CA, Bidlow CM, Lustigman S, Cho-Ngwa F, Williams D, Rascón AA, Tricoche N, Samje M, Bell A, Suzuki B, Lim KC, Supakorndej N, Supakorndej P, Wolfe AR, Knudsen GM, Chen S, Wilson C, Ang KH, Arkin M, Gut J, Franklin C, Marcellino C, McKerrow JH, Debnath A, Sakanari J. Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis. PLoS Negl Trop Dis. 2015 Feb; 9(2):e0003534. PMID: 25700363; PMCID: PMC4336141.
    3. Geary TG, Sakanari J, Caffrey CR. Anthelmintic drug discovery: into the future. J Parasitol. 2015 Apr; 101(2):125-33. PMID: 25584662.
      View in: PubMed
    4. Storey B, Marcellino C, Miller M, Maclean M, Mostafa E, Howell S, Sakanari J, Wolstenholme A, Kaplan R. Utilization of computer processed high definition video imaging for measuring motility of microscopic nematode stages on a quantitative scale: "The Worminator". Int J Parasitol Drugs Drug Resist. 2014 Dec; 4(3):233-43. PMID: 25516834; PMCID: PMC4266792.
    5. Ndao M, Nath-Chowdhury M, Sajid M, Marcus V, Mashiyama ST, Sakanari J, Chow E, Mackey Z, Land KM, Jacobson MP, Kalyanaraman C, McKerrow JH, Arrowood MJ, Caffrey CR. A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infection. Antimicrob Agents Chemother. 2013 Dec; 57(12):6063-73. PMID: 24060869; PMCID: PMC3837922.
    6. Ingram JR, Rafi SB, Eroy-Reveles AA, Ray M, Lambeth L, Hsieh I, Ruelas D, Lim KC, Sakanari J, Craik CS, Jacobson MP, McKerrow JH. Investigation of the proteolytic functions of an expanded cercarial elastase gene family in Schistosoma mansoni. PLoS Negl Trop Dis. 2012; 6(4):e1589. PMID: 22509414; PMCID: PMC3317910.
    7. Marcellino C, Gut J, Lim KC, Singh R, McKerrow J, Sakanari J. WormAssay: a novel computer application for whole-plate motion-based screening of macroscopic parasites. PLoS Negl Trop Dis. 2012 Jan; 6(1):e1494. PMID: 22303493; PMCID: PMC3269415.
    8. Ingram J, Knudsen G, Lim KC, Hansell E, Sakanari J, McKerrow J. Proteomic analysis of human skin treated with larval schistosome peptidases reveals distinct invasion strategies among species of blood flukes. PLoS Negl Trop Dis. 2011 Sep; 5(9):e1337. PMID: 21980548; PMCID: PMC3181243.
    9. DuBois KN, Abodeely M, Sakanari J, Craik CS, Lee M, McKerrow JH, Sajid M. Identification of the major cysteine protease of Giardia and its role in encystation. J Biol Chem. 2008 Jun 27; 283(26):18024-31. PMID: 18445589; PMCID: PMC2440617.
    10. Nadler SA, D'Amelio S, Dailey MD, Paggi L, Siu S, Sakanari J. Molecular phylogenetics and diagnosis of Anisakis, Pseudoterranova, and Contracaecum from northern Pacific marine mammals. J Parasitol. 2005 Dec; 91(6):1413-29. PMID: 16539026.
      View in: PubMed
    11. Kim YM, Hwang HA, Yun WS, Kim SI, Lee KW, Park SK, Lee YJ, Kim TK, Wongsrichanalai C, Sakanari J, Park H. Efficacy of the merozoite surface protein 1 of Plasmodium vivax as an antigen for ELISA to diagnose malaria. Yonsei Med J. 2004 Feb 29; 45(1):129-34. PMID: 15004879.
      View in: PubMed
    12. Park SY, Lee KH, Hwang YB, Kim KY, Park SK, Hwang HA, Sakanari J, Hong KM, Kim SI, Park H. Characterization and large-scale expression of the recombinant cysteine proteinase from adult Clonorchis sinensis. J Parasitol. 2001 Dec; 87(6):1454-8. PMID: 11780837.
      View in: PubMed
    13. Park H, Hong KM, Sakanari J, Choi JH, Park SK, Kim KY, Hwang HA, Paik MK, Yun KJ, Shin CH, Lee JB, Ryu JS, Min DY. Paragonimus westermani: cloning of a cathepsin F-like cysteine proteinase from the adult worm. Exp Parasitol. 2001 Aug; 98(4):223-7. PMID: 11560415.
      View in: PubMed
    14. Selzer PM, Pingel S, Hsieh I, Ugele B, Chan VJ, Engel JC, Bogyo M, Russell DG, Sakanari J, McKerrow JH. Cysteine protease inhibitors as chemotherapy: lessons from a parasite target. Proc Natl Acad Sci U S A. 1999 Sep 28; 96(20):11015-22. PMID: 10500116; PMCID: PMC34234.
    15. Nguyen TT, Qasim MA, Morris S, Lu CC, Hill D, Laskowski M, Sakanari J. Expression and characterization of elastase inhibitors from the ascarid nematodes Anisakis simplex and Ascaris suum. Mol Biochem Parasitol. 1999 Jul 30; 102(1):79-89. PMID: 10477178.
      View in: PubMed
    16. Chan VJ, Selzer PM, McKerrow JH, Sakanari J. Expression and alteration of the S2 subsite of the Leishmania major cathepsin B-like cysteine protease. Biochem J. 1999 May 15; 340 ( Pt 1):113-7. PMID: 10229665; PMCID: PMC1220228.
    17. Lu CC, Nguyen T, Morris S, Hill D, Sakanari J. Anisakis simplex: mutational bursts in the reactive site centers of serine protease inhibitors from an ascarid nematode. Exp Parasitol. 1998 Jun; 89(2):257-61. PMID: 9635450.
      View in: PubMed
    18. Selzer PM, Chen X, Chan VJ, Cheng M, Kenyon GL, Kuntz ID, Sakanari J, Cohen FE, McKerrow JH. Leishmania major: molecular modeling of cysteine proteases and prediction of new nonpeptide inhibitors. Exp Parasitol. 1997 Nov; 87(3):212-21. PMID: 9371086.
      View in: PubMed
    19. Sakanari J, Nadler SA, Chan VJ, Engel JC, Leptak C, Bouvier J. Leishmania major: comparison of the cathepsin L- and B-like cysteine protease genes with those of other trypanosomatids. Exp Parasitol. 1997 Jan; 85(1):63-76. PMID: 9024203.
      View in: PubMed
    20. Hagen HE, Kläger SL, Chan V, Sakanari J, McKerrow JH, Ham PJ. Simulium damnosum s.l.: identification of inducible serine proteases following an Onchocerca infection by differential display reverse transcription PCR. Exp Parasitol. 1995 Nov; 81(3):249-54. PMID: 7498421.
      View in: PubMed
    21. McGrath ME, Hines WM, Sakanari J, Fletterick RJ, Craik CS. The sequence and reactive site of ecotin. A general inhibitor of pancreatic serine proteases from Escherichia coli. J Biol Chem. 1991 Apr 05; 266(10):6620-5. PMID: 2007606.
      View in: PubMed
    22. Sakanari J, McKerrow JH. Identification of the secreted neutral proteases from Anisakis simplex. J Parasitol. 1990 Oct; 76(5):625-30. PMID: 2213405.
      View in: PubMed
    23. Sakanari J, Moser M. Adaptation of an introduced host to an indigenous parasite. J Parasitol. 1990 Jun; 76(3):420-3. PMID: 2352072.
      View in: PubMed
    24. Eakin AE, Bouvier J, Sakanari J, Craik CS, McKerrow JH. Amplification and sequencing of genomic DNA fragments encoding cysteine proteases from protozoan parasites. Mol Biochem Parasitol. 1990 Feb; 39(1):1-8. PMID: 2406590.
      View in: PubMed
    25. Sakanari J, Staunton CE, Eakin AE, Craik CS, McKerrow JH. Serine proteases from nematode and protozoan parasites: isolation of sequence homologs using generic molecular probes. Proc Natl Acad Sci U S A. 1989 Jul; 86(13):4863-7. PMID: 2662185; PMCID: PMC297515.
    26. Sakanari J, McKerrow JH. Anisakiasis. Clin Microbiol Rev. 1989 Jul; 2(3):278-84. PMID: 2670191; PMCID: PMC358121.
    27. Lackey A, James ER, Sakanari J, Resnick SD, Brown M, Bianco AE, McKerrow JH. Extracellular proteases of Onchocerca. Exp Parasitol. 1989 Feb; 68(2):176-85. PMID: 2647506.
      View in: PubMed
    28. McKerrow JH, Sakanari J, Deardorff TL. Anisakiasis: revenge of the sushi parasite. N Engl J Med. 1988 Nov 03; 319(18):1228-9. PMID: 3173465.
      View in: PubMed
    29. Sakanari J, Loinaz HM, Deardorff TL, Raybourne RB, McKerrow JH, Frierson JG. Intestinal anisakiasis. A case diagnosed by morphologic and immunologic methods. Am J Clin Pathol. 1988 Jul; 90(1):107-13. PMID: 3291604.
      View in: PubMed
    30. Amiri P, Sakanari J, Basch P, Newport G, McKerrow JH. The Schistosomatium douthitti cercarial elastase is biochemically and structurally distinct from that of Schistosoma mansoni. Mol Biochem Parasitol. 1988 Mar; 28(2):113-20. PMID: 2452979.
      View in: PubMed
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