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Roland Bainton, MD, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentAnesthesia
Address600 16th Street
San Francisco CA 94158
Phone415-514-4076
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoM.D.1994 Medicine
    University of California, San FranciscoPh.D.1992 Graduate Division (Biochemistry)

    Collapse Research 
    Collapse Research Activities and Funding
    Discovering fundamental metabolic control processes of the blood brain barrier
    NIH/NINDS R21NS082856Feb 1, 2013 - Jan 31, 2015
    Role: Principal Investigator
    A platform for rapid characterization of metabolic disrupters in whole animals
    NIH/NIEHS R21ES021412May 25, 2012 - Apr 30, 2014
    Role: Principal Investigator
    Physiology and regulation of drug transport across the blood brain barrier
    NIH/NIGMS R01GM081863Aug 1, 2007 - May 31, 2013
    Role: Principal Investigator
    A GENETIC STUDY OF DROSOPHILA RESPONSES TO COCAINE
    NIH/NIDA K08DA000481Sep 20, 2000 - Feb 28, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hindle SJ, Bainton R. Barrier mechanisms in the Drosophila blood-brain barrier. Front Neurosci. 2014; 8:414. PMID: 25565944; PMCID: PMC4267209.
    2. DeSalvo MK, Hindle SJ, Rusan ZM, Orng S, Eddison M, Halliwill K, Bainton R. The Drosophila surface glia transcriptome: evolutionary conserved blood-brain barrier processes. Front Neurosci. 2014; 8:346. PMID: 25426014; PMCID: PMC4224204.
    3. Lemieux GA, Keiser MJ, Sassano MF, Laggner C, Mayer F, Bainton R, Werb Z, Roth BL, Shoichet BK, Ashrafi K. In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding. PLoS Biol. 2013 Nov; 11(11):e1001712. PMID: 24260022; PMCID: PMC3833878.
    4. Lemieux GA, Liu J, Mayer N, Bainton R, Ashrafi K, Werb Z. A whole-organism screen identifies new regulators of fat storage. Nat Chem Biol. 2011 Apr; 7(4):206-13. PMID: 21390037; PMCID: PMC3076723.
    5. DeSalvo MK, Mayer N, Mayer F, Bainton R. Physiologic and anatomic characterization of the brain surface glia barrier of Drosophila. Glia. 2011 Sep; 59(9):1322-40. PMID: 21351158; PMCID: PMC3130812.
    6. Pinsonneault RL, Mayer N, Mayer F, Tegegn N, Bainton R. Novel models for studying the blood-brain and blood-eye barriers in Drosophila. Methods Mol Biol. 2011; 686:357-69. PMID: 21082381; PMCID: PMC3040118.
    7. Kong EC, Woo K, Li H, Lebestky T, Mayer N, Sniffen MR, Heberlein U, Bainton R, Hirsh J, Wolf FW. A pair of dopamine neurons target the D1-like dopamine receptor DopR in the central complex to promote ethanol-stimulated locomotion in Drosophila. PLoS One. 2010; 5(4):e9954. PMID: 20376353; PMCID: PMC2848596.
    8. Mayer F, Mayer N, Chinn L, Pinsonneault RL, Kroetz D, Bainton R. Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila. J Neurosci. 2009 Mar 18; 29(11):3538-50. PMID: 19295159; PMCID: PMC3040577.
    9. Banerjee S, Bainton R, Mayer N, Beckstead R, Bhat MA. Septate junctions are required for ommatidial integrity and blood-eye barrier function in Drosophila. Dev Biol. 2008 May 15; 317(2):585-99. PMID: 18407259; PMCID: PMC2423378.
    10. Stork T, Engelen D, Krudewig A, Silies M, Bainton R, Klämbt C. Organization and function of the blood-brain barrier in Drosophila. J Neurosci. 2008 Jan 16; 28(3):587-97. PMID: 18199760.
      View in: PubMed
    11. Rothenfluh A, Threlkeld RJ, Bainton R, Tsai LT, Lasek AW, Heberlein U. Distinct behavioral responses to ethanol are regulated by alternate RhoGAP18B isoforms. Cell. 2006 Oct 6; 127(1):199-211. PMID: 17018286.
      View in: PubMed
    12. Chang HY, Grygoruk A, Brooks ES, Ackerson LC, Maidment NT, Bainton R, Krantz DE. Overexpression of the Drosophila vesicular monoamine transporter increases motor activity and courtship but decreases the behavioral response to cocaine. Mol Psychiatry. 2006 Jan; 11(1):99-113. PMID: 16189511.
      View in: PubMed
    13. Bainton R, Tsai LT, Schwabe T, DeSalvo M, Gaul U, Heberlein U. moody encodes two GPCRs that regulate cocaine behaviors and blood-brain barrier permeability in Drosophila. Cell. 2005 Oct 7; 123(1):145-56. PMID: 16213219.
      View in: PubMed
    14. Schwabe T, Bainton R, Fetter RD, Heberlein U, Gaul U. GPCR signaling is required for blood-brain barrier formation in drosophila. Cell. 2005 Oct 7; 123(1):133-44. PMID: 16213218.
      View in: PubMed
    15. Greer CL, Grygoruk A, Patton DE, Ley B, Romero-Calderon R, Chang HY, Houshyar R, Bainton R, Diantonio A, Krantz DE. A splice variant of the Drosophila vesicular monoamine transporter contains a conserved trafficking domain and functions in the storage of dopamine, serotonin, and octopamine. J Neurobiol. 2005 Sep 5; 64(3):239-58. PMID: 15849736.
      View in: PubMed
    16. Tsai LT, Bainton R, Blau J, Heberlein U. Lmo mutants reveal a novel role for circadian pacemaker neurons in cocaine-induced behaviors. PLoS Biol. 2004 Dec; 2(12):e408. PMID: 15550987; PMCID: PMC529317.
    17. Kunwar PS, Starz-Gaiano M, Bainton R, Heberlein U, Lehmann R. Tre1, a G protein-coupled receptor, directs transepithelial migration of Drosophila germ cells. PLoS Biol. 2003 Dec; 1(3):E80. PMID: 14691551; PMCID: PMC300690.
    18. Bainton R, Tsai LT, Singh CM, Moore MS, Neckameyer WS, Heberlein U. Dopamine modulates acute responses to cocaine, nicotine and ethanol in Drosophila. Curr Biol. 2000 Feb 24; 10(4):187-94. PMID: 10704411.
      View in: PubMed
    19. Gary PA, Biery MC, Bainton R, Craig NL. Multiple DNA processing reactions underlie Tn7 transposition. J Mol Biol. 1996 Mar 29; 257(2):301-16. PMID: 8609625.
      View in: PubMed
    20. Bainton R, Kubo KM, Feng JN, Craig NL. Tn7 transposition: target DNA recognition is mediated by multiple Tn7-encoded proteins in a purified in vitro system. Cell. 1993 Mar 26; 72(6):931-43. PMID: 8384534.
      View in: PubMed
    21. Bainton R, Gamas P, Craig NL. Tn7 transposition in vitro proceeds through an excised transposon intermediate generated by staggered breaks in DNA. Cell. 1991 May 31; 65(5):805-16. PMID: 1645619.
      View in: PubMed
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