Roland Bainton, MD, PhD

Title(s)Professor, Anesthesia
SchoolSchool of Medicine
Address600 16th Street, #001
San Francisco CA 94158
Phone415-514-4076
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoM.D.1994 Medicine
    University of California, San FranciscoPh.D.1992 Graduate Division (Biochemistry)

    Collapse Research 
    Collapse Research Activities and Funding
    Discovering fundamental metabolic control processes of the blood brain barrier
    NIH R21NS082856Feb 1, 2013 - Jan 31, 2017
    Role: Principal Investigator
    A platform for rapid characterization of metabolic disrupters in whole animals
    NIH R21ES021412May 25, 2012 - Apr 30, 2015
    Role: Principal Investigator
    Physiology and regulation of drug transport across the blood brain barrier
    NIH R01GM081863Aug 1, 2007 - May 31, 2013
    Role: Principal Investigator
    A GENETIC STUDY OF DROSOPHILA RESPONSES TO COCAINE
    NIH K08DA000481Sep 20, 2000 - Feb 28, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Effects of the circulating environment of COVID-19 on platelet and neutrophil behavior. Front Immunol. 2023; 14:1130288. Fields AT, Andraska EA, Kaltenmeier C, Matthay ZA, Herrera K, Nuñez-Garcia B, Jones CM, Wick KD, Liu S, Luo JH, Yu YP, Matthay MA, Hendrickson CM, Bainton RJ, Barrett TJ, Berger JS, Neal MD, Kornblith LZ. PMID: 36999030; PMCID: PMC10043426.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    2. COVID-19-associated Lung Microvascular Endotheliopathy: A "From the Bench" Perspective. Am J Respir Crit Care Med. 2022 10 15; 206(8):961-972. Joffre J, Rodriguez L, Matthay ZA, Lloyd E, Fields AT, Bainton RJ, Kurien P, Sil A, Calfee CS, Woodruff PG, Erle DJ, Hendrickson C, Krummel MF, Langelier CR, Matthay MA, Kornblith LZ, Hellman J, COVID-19 Multi-Phenotyping for Effective Therapies (COMET) Consortium, COVID-19 Associated Coagulopathy, Inflammation, and Thrombosis (Co-ACIT) Study Group. PMID: 35649173; PMCID: PMC9801996.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    3. A new trauma frontier: Exploratory pilot study of platelet transcriptomics in trauma patients. J Trauma Acute Care Surg. 2022 02 01; 92(2):313-322. Fields AT, Lee MC, Mayer F, Santos YA, Bainton CMV, Matthay ZA, Callcut RA, Mayer N, Cuschieri J, Kober KM, Bainton RJ, Kornblith LZ. PMID: 34738997; PMCID: PMC8781218.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    4. Good Platelets Gone Bad: The Effects of Trauma Patient Plasma on Healthy Platelet Aggregation. Shock. 2021 02 01; 55(2):189-197. Fields AT, Matthay ZA, Nunez-Garcia B, Matthay EC, Bainton RJ, Callcut RA, Kornblith LZ. PMID: 32694397; PMCID: PMC8547718.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    5. Clinical Evaluation of a COVID-19 Antibody Lateral Flow Assay using Point of Care Samples. medRxiv. 2020 Dec 04. Lee W, Straube S, Sincic R, Noble JA, Montoy JC, Kornblith AE, Prakash A, Wang R, Bainton RJ, Kurien PA. PMID: 33300003; PMCID: PMC7724668.
      View in: PubMed   Mentions:
    6. A journey upstream: Fluctuating platelet-specific genes in cell-free plasma as proof-of-concept for using ribonucleic acid sequencing to improve understanding of postinjury platelet biology. J Trauma Acute Care Surg. 2020 06; 88(6):742-751. Kornblith LZ, Bainton CMV, Fields AT, Matthay ZA, Magid NT, Nunez-Garcia B, Prakash A, Kurien PA, Callcut RA, Cohen MJ, Bainton RJ. PMID: 32195992; PMCID: PMC7571783.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. Evolutionarily Conserved Roles for Blood-Brain Barrier Xenobiotic Transporters in Endogenous Steroid Partitioning and Behavior. Cell Rep. 2017 Oct 31; 21(5):1304-1316. Hindle SJ, Munji RN, Dolghih E, Gaskins G, Orng S, Ishimoto H, Soung A, DeSalvo M, Kitamoto T, Keiser MJ, Jacobson MP, Daneman R, Bainton RJ. PMID: 29091768; PMCID: PMC5774027.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    8. Barrier mechanisms in the Drosophila blood-brain barrier. Front Neurosci. 2014; 8:414. Hindle SJ, Bainton RJ. PMID: 25565944; PMCID: PMC4267209.
      View in: PubMed   Mentions: 60  
    9. The Drosophila surface glia transcriptome: evolutionary conserved blood-brain barrier processes. Front Neurosci. 2014; 8:346. DeSalvo MK, Hindle SJ, Rusan ZM, Orng S, Eddison M, Halliwill K, Bainton RJ. PMID: 25426014; PMCID: PMC4224204.
      View in: PubMed   Mentions: 65  
    10. In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding. PLoS Biol. 2013 Nov; 11(11):e1001712. Lemieux GA, Keiser MJ, Sassano MF, Laggner C, Mayer F, Bainton RJ, Werb Z, Roth BL, Shoichet BK, Ashrafi K. PMID: 24260022; PMCID: PMC3833878.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    11. A whole-organism screen identifies new regulators of fat storage. Nat Chem Biol. 2011 Apr; 7(4):206-13. Lemieux GA, Liu J, Mayer N, Bainton RJ, Ashrafi K, Werb Z. PMID: 21390037; PMCID: PMC3076723.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    12. Physiologic and anatomic characterization of the brain surface glia barrier of Drosophila. Glia. 2011 Sep; 59(9):1322-40. DeSalvo MK, Mayer N, Mayer F, Bainton RJ. PMID: 21351158; PMCID: PMC3130812.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    13. Novel models for studying the blood-brain and blood-eye barriers in Drosophila. Methods Mol Biol. 2011; 686:357-69. Pinsonneault RL, Mayer N, Mayer F, Tegegn N, Bainton RJ. PMID: 21082381; PMCID: PMC3040118.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    14. A pair of dopamine neurons target the D1-like dopamine receptor DopR in the central complex to promote ethanol-stimulated locomotion in Drosophila. PLoS One. 2010 Apr 01; 5(4):e9954. Kong EC, Woo K, Li H, Lebestky T, Mayer N, Sniffen MR, Heberlein U, Bainton RJ, Hirsh J, Wolf FW. PMID: 20376353; PMCID: PMC2848596.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCells
    15. Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila. J Neurosci. 2009 Mar 18; 29(11):3538-50. Mayer F, Mayer N, Chinn L, Pinsonneault RL, Kroetz D, Bainton RJ. PMID: 19295159; PMCID: PMC3040577.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    16. Septate junctions are required for ommatidial integrity and blood-eye barrier function in Drosophila. Dev Biol. 2008 May 15; 317(2):585-99. Banerjee S, Bainton RJ, Mayer N, Beckstead R, Bhat MA. PMID: 18407259; PMCID: PMC2423378.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    17. Organization and function of the blood-brain barrier in Drosophila. J Neurosci. 2008 Jan 16; 28(3):587-97. Stork T, Engelen D, Krudewig A, Silies M, Bainton RJ, Klämbt C. PMID: 18199760; PMCID: PMC6670337.
      View in: PubMed   Mentions: 178     Fields:    Translation:AnimalsCells
    18. Distinct behavioral responses to ethanol are regulated by alternate RhoGAP18B isoforms. Cell. 2006 Oct 06; 127(1):199-211. Rothenfluh A, Threlkeld RJ, Bainton RJ, Tsai LT, Lasek AW, Heberlein U. PMID: 17018286.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    19. Overexpression of the Drosophila vesicular monoamine transporter increases motor activity and courtship but decreases the behavioral response to cocaine. Mol Psychiatry. 2006 Jan; 11(1):99-113. Chang HY, Grygoruk A, Brooks ES, Ackerson LC, Maidment NT, Bainton RJ, Krantz DE. PMID: 16189511.
      View in: PubMed   Mentions: 66     Fields:    Translation:Animals
    20. moody encodes two GPCRs that regulate cocaine behaviors and blood-brain barrier permeability in Drosophila. Cell. 2005 Oct 07; 123(1):145-56. Bainton RJ, Tsai LT, Schwabe T, DeSalvo M, Gaul U, Heberlein U. PMID: 16213219.
      View in: PubMed   Mentions: 122     Fields:    Translation:AnimalsCells
    21. GPCR signaling is required for blood-brain barrier formation in drosophila. Cell. 2005 Oct 07; 123(1):133-44. Schwabe T, Bainton RJ, Fetter RD, Heberlein U, Gaul U. PMID: 16213218.
      View in: PubMed   Mentions: 130     Fields:    Translation:AnimalsCells
    22. A splice variant of the Drosophila vesicular monoamine transporter contains a conserved trafficking domain and functions in the storage of dopamine, serotonin, and octopamine. J Neurobiol. 2005 Sep 05; 64(3):239-58. Greer CL, Grygoruk A, Patton DE, Ley B, Romero-Calderon R, Chang HY, Houshyar R, Bainton RJ, Diantonio A, Krantz DE. PMID: 15849736.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    23. Lmo mutants reveal a novel role for circadian pacemaker neurons in cocaine-induced behaviors. PLoS Biol. 2004 Dec; 2(12):e408. Tsai LT, Bainton RJ, Blau J, Heberlein U. PMID: 15550987; PMCID: PMC529317.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    24. Tre1, a G protein-coupled receptor, directs transepithelial migration of Drosophila germ cells. PLoS Biol. 2003 Dec; 1(3):E80. Kunwar PS, Starz-Gaiano M, Bainton RJ, Heberlein U, Lehmann R. PMID: 14691551; PMCID: PMC300690.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    25. Dopamine modulates acute responses to cocaine, nicotine and ethanol in Drosophila. Curr Biol. 2000 Feb 24; 10(4):187-94. Bainton RJ, Tsai LT, Singh CM, Moore MS, Neckameyer WS, Heberlein U. PMID: 10704411.
      View in: PubMed   Mentions: 132     Fields:    Translation:Animals
    26. Multiple DNA processing reactions underlie Tn7 transposition. J Mol Biol. 1996 Mar 29; 257(2):301-16. Gary PA, Biery MC, Bainton RJ, Craig NL. PMID: 8609625.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    27. Tn7 transposition: target DNA recognition is mediated by multiple Tn7-encoded proteins in a purified in vitro system. Cell. 1993 Mar 26; 72(6):931-43. Bainton RJ, Kubo KM, Feng JN, Craig NL. PMID: 8384534.
      View in: PubMed   Mentions: 87     Fields:    Translation:Cells
    28. Tn7 transposition in vitro proceeds through an excised transposon intermediate generated by staggered breaks in DNA. Cell. 1991 May 31; 65(5):805-16. Bainton R, Gamas P, Craig NL. PMID: 1645619.
      View in: PubMed   Mentions: 71     Fields:    Translation:Cells
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