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Roland Bainton, MD, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentAnesthesia
Address600 16th St
San Francisco CA 94158
Phone415-514-4076
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoM.D.1994 Medicine
    University of California, San FranciscoPh.D.1992 Graduate Division (Biochemistry)

    Collapse Research 
    Collapse Research Activities and Funding
    Discovering fundamental metabolic control processes of the blood brain barrier
    NIH/NINDS R21NS082856Feb 1, 2013 - Jan 31, 2015
    Role: Principal Investigator
    A platform for rapid characterization of metabolic disrupters in whole animals
    NIH/NIEHS R21ES021412May 25, 2012 - Apr 30, 2014
    Role: Principal Investigator
    Physiology and regulation of drug transport across the blood brain barrier
    NIH/NIGMS R01GM081863Aug 1, 2007 - May 31, 2013
    Role: Principal Investigator
    A GENETIC STUDY OF DROSOPHILA RESPONSES TO COCAINE
    NIH/NIDA K08DA000481Sep 20, 2000 - Feb 28, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hindle SJ, Munji RN, Dolghih E, Gaskins G, Orng S, Ishimoto H, Soung A, DeSalvo M, Kitamoto T, Keiser MJ, Jacobson MP, Daneman R, Bainton RJ. Evolutionarily Conserved Roles for Blood-Brain Barrier Xenobiotic Transporters in Endogenous Steroid Partitioning and Behavior. Cell Rep. 2017 Oct 31; 21(5):1304-1316. PMID: 29091768.
      View in: PubMed
    2. Hindle SJ, Bainton RJ. Barrier mechanisms in the Drosophila blood-brain barrier. Front Neurosci. 2014; 8:414. PMID: 25565944; PMCID: PMC4267209.
    3. DeSalvo MK, Hindle SJ, Rusan ZM, Orng S, Eddison M, Halliwill K, Bainton RJ. The Drosophila surface glia transcriptome: evolutionary conserved blood-brain barrier processes. Front Neurosci. 2014; 8:346. PMID: 25426014; PMCID: PMC4224204.
    4. Lemieux GA, Keiser MJ, Sassano MF, Laggner C, Mayer F, Bainton RJ, Werb Z, Roth BL, Shoichet BK, Ashrafi K. In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding. PLoS Biol. 2013 Nov; 11(11):e1001712. PMID: 24260022; PMCID: PMC3833878.
    5. Lemieux GA, Liu J, Mayer N, Bainton RJ, Ashrafi K, Werb Z. A whole-organism screen identifies new regulators of fat storage. Nat Chem Biol. 2011 Apr; 7(4):206-13. PMID: 21390037; PMCID: PMC3076723.
    6. DeSalvo MK, Mayer N, Mayer F, Bainton RJ. Physiologic and anatomic characterization of the brain surface glia barrier of Drosophila. Glia. 2011 Sep; 59(9):1322-40. PMID: 21351158; PMCID: PMC3130812.
    7. Pinsonneault RL, Mayer N, Mayer F, Tegegn N, Bainton RJ. Novel models for studying the blood-brain and blood-eye barriers in Drosophila. Methods Mol Biol. 2011; 686:357-69. PMID: 21082381; PMCID: PMC3040118.
    8. Kong EC, Woo K, Li H, Lebestky T, Mayer N, Sniffen MR, Heberlein U, Bainton RJ, Hirsh J, Wolf FW. A pair of dopamine neurons target the D1-like dopamine receptor DopR in the central complex to promote ethanol-stimulated locomotion in Drosophila. PLoS One. 2010 Apr 01; 5(4):e9954. PMID: 20376353; PMCID: PMC2848596.
    9. Mayer F, Mayer N, Chinn L, Pinsonneault RL, Kroetz D, Bainton RJ. Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila. J Neurosci. 2009 Mar 18; 29(11):3538-50. PMID: 19295159; PMCID: PMC3040577.
    10. Banerjee S, Bainton RJ, Mayer N, Beckstead R, Bhat MA. Septate junctions are required for ommatidial integrity and blood-eye barrier function in Drosophila. Dev Biol. 2008 May 15; 317(2):585-99. PMID: 18407259; PMCID: PMC2423378.
    11. Stork T, Engelen D, Krudewig A, Silies M, Bainton RJ, Klämbt C. Organization and function of the blood-brain barrier in Drosophila. J Neurosci. 2008 Jan 16; 28(3):587-97. PMID: 18199760.
      View in: PubMed
    12. Rothenfluh A, Threlkeld RJ, Bainton RJ, Tsai LT, Lasek AW, Heberlein U. Distinct behavioral responses to ethanol are regulated by alternate RhoGAP18B isoforms. Cell. 2006 Oct 06; 127(1):199-211. PMID: 17018286.
      View in: PubMed
    13. Bainton RJ, Tsai LT, Schwabe T, DeSalvo M, Gaul U, Heberlein U. moody encodes two GPCRs that regulate cocaine behaviors and blood-brain barrier permeability in Drosophila. Cell. 2005 Oct 07; 123(1):145-56. PMID: 16213219.
      View in: PubMed
    14. Schwabe T, Bainton RJ, Fetter RD, Heberlein U, Gaul U. GPCR signaling is required for blood-brain barrier formation in drosophila. Cell. 2005 Oct 07; 123(1):133-44. PMID: 16213218.
      View in: PubMed
    15. Greer CL, Grygoruk A, Patton DE, Ley B, Romero-Calderon R, Chang HY, Houshyar R, Bainton RJ, Diantonio A, Krantz DE. A splice variant of the Drosophila vesicular monoamine transporter contains a conserved trafficking domain and functions in the storage of dopamine, serotonin, and octopamine. J Neurobiol. 2005 Sep 05; 64(3):239-58. PMID: 15849736.
      View in: PubMed
    16. Tsai LT, Bainton RJ, Blau J, Heberlein U. Lmo mutants reveal a novel role for circadian pacemaker neurons in cocaine-induced behaviors. PLoS Biol. 2004 Dec; 2(12):e408. PMID: 15550987; PMCID: PMC529317.
    17. Kunwar PS, Starz-Gaiano M, Bainton RJ, Heberlein U, Lehmann R. Tre1, a G protein-coupled receptor, directs transepithelial migration of Drosophila germ cells. PLoS Biol. 2003 Dec; 1(3):E80. PMID: 14691551; PMCID: PMC300690.
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