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Licia Selleri, PhD, MD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentOrofacial Sciences
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-502-2263
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    Collapse Biography 
    Collapse Education and Training
    Ginnasio Ludovico MuratoriBaccalaureat1980
    University of ModenaM.D. 1985Medical School
    University of Modena, and Erasmus University (Advisors: Dr. Umberto Torelli & Dr. Gerard Grosveld)Ph.D. Molecular Biology1990Graduate School
    The Salk Institute for Biological Studies, Molecular Genetics Laboratory (Advisor: Dr. Glen Evans)“Fogarty” Postdoctoral Fellow1992

    Collapse Overview 
    Collapse Overview
    UCSF School of Medicine
    Department of Anatomy
    Institute of Human Genetics
    Eli and Edythe Broad Center of Regeneration Medicine & Stem Cell Research

    Genetic and regulatory control of morphogenesis in embryonic development, evolution, and disease

    The laboratory studies the genetic and regulatory basis of how elaborately patterned tissues form during embryonic development and evolution. The laboratory combines different genetic approaches, using the mouse as a model, to understand the mechanisms underpinning basic developmental processes related to cranial and appendicular morphogenesis. They discovered that homeodomain-containing transcription factors of the Pbx family, also known as Hox-cofactors, are critical developmental regulators through the transcriptional control of target genes within tissue-specific regulatory networks. The lab uses genetically-engineered and ethylnitrosourea (ENU)-mutagenized mouse lines. Recently they utilize additional animal models, such as jerboas and primates, with the ultimate goal to identify novel genes and regulatory networks underlying morphogenesis of embryonic structures, morphological variation, and evolution. Focus is also given to how perturbation of these regulatory networks can result in human congenital disease.


    Collapse Research 
    Collapse Research Activities and Funding
    Pbx-Directed Control of Cellular Behaviors that Drive Midface Morphogenesis
    NIH/NIDCR R01DE024745Jul 1, 2015 - May 31, 2020
    Role: Principal Investigator
    Epigenetic landscapes and regulatory divergence of human craniofacial traits
    NIH/NIDCR U01DE024430May 22, 2014 - Apr 30, 2019
    Role: Co-Principal Investigator
    Genetic and Transcriptional Control of Spleen Development
    NIH/NICHD R01HD061403Sep 15, 2010 - May 31, 2015
    Role: Principal Investigator
    CLONING OF THE Hol MUTATION
    NIH/NIDCR R21DE018031Apr 1, 2008 - Mar 31, 2011
    Role: Principal Investigator
    Mechanisms of Pbx-directed Genetic & Transcriptional Control of Limb Development
    NIH/NICHD R01HD043997Apr 1, 2003 - Dec 31, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Global Health
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bolze A, Boisson B, Bosch B, Antipenko A, Bouaziz M, Sackstein P, Chaker-Margot M, Barlogis V, Briggs T, Colino E, Elmore AC, Fischer A, Genel F, Hewlett A, Jedidi M, Kelecic J, Krüger R, Ku CL, Kumararatne D, Lefevre-Utile A, Loughlin S, Mahlaoui N, Markus S, Garcia JM, Nizon M, Oleastro M, Pac M, Picard C, Pollard AJ, Rodriguez-Gallego C, Thomas C, Von Bernuth H, Worth A, Meyts I, Risolino M, Selleri L, Puel A, Klinge S, Abel L, Casanova JL. Incomplete penetrance for isolated congenital asplenia in humans with mutations in translated and untranslated RPSA exons. Proc Natl Acad Sci U S A. 2018 Aug 02. PMID: 30072435.
      View in: PubMed
    2. Welsh IC, Hart J, Brown JM, Hansen K, Rocha Marques M, Aho RJ, Grishina I, Hurtado R, Herzlinger D, Ferretti E, Garcia-Garcia MJ, Selleri L. Pbx loss in cranial neural crest, unlike in epithelium, results in cleft palate only and a broader midface. J Anat. 2018 May 23. PMID: 29797482.
      View in: PubMed
    3. Losa M, Risolino M, Li B, Hart J, Quintana L, Grishina I, Yang H, Choi IF, Lewicki P, Khan S, Aho R, Feenstra J, Vincent CT, Brown AMC, Ferretti E, Williams T, Selleri L. Face morphogenesis is promoted by Pbx-dependent EMT via regulation of Snail1 during frontonasal prominence fusion. Development. 2018 03 01; 145(5). PMID: 29437830.
      View in: PubMed
    4. McCulley DJ, Wienhold MD, Hines EA, Hacker TA, Rogers A, Pewowaruk RJ, Zewdu R, Chesler NC, Selleri L, Sun X. PBX transcription factors drive pulmonary vascular adaptation to birth. J Clin Invest. 2018 Feb 01; 128(2):655-667. PMID: 29251627.
      View in: PubMed
    5. Slavotinek A, Risolino M, Losa M, Cho MT, Monaghan KG, Schneidman-Duhovny D, Parisotto S, Herkert JC, Stegmann APA, Miller K, Shur N, Chui J, Muller E, DeBrosse S, Szot JO, Chapman G, Pachter NS, Winlaw DS, Mendelsohn BA, Dalton J, Sarafoglou K, Karachunski PI, Lewis JM, Pedro H, Dunwoodie SL, Selleri L, Shieh J. De novo, deleterious sequence variants that alter the transcriptional activity of the homeoprotein PBX1 are associated with intellectual disability and pleiotropic developmental defects. Hum Mol Genet. 2017 Dec 15; 26(24):4849-4860. PMID: 29036646.
      View in: PubMed
    6. Dong X, Landford WN, Hart J, Risolino M, Kaymakcalan O, Jin J, Toyoda Y, Ferretti E, Selleri L, Spector JA. Toward Microsurgical Correction of Cleft Lip Ex Utero through Restoration of Craniofacial Developmental Programs. Plast Reconstr Surg. 2017 Jul; 140(1):75-85. PMID: 28338586.
      View in: PubMed
    7. Selleri L, Bartolomei MS, Bickmore WA, He L, Stubbs L, Reik W, Barsh GS. A Hox-Embedded Long Noncoding RNA: Is It All Hot Air? PLoS Genet. 2016 Dec; 12(12):e1006485. PMID: 27977680.
      View in: PubMed
    8. Jung JG, Shih IM, Park JT, Gerry E, Kim TH, Ayhan A, Handschuh K, Davidson B, Fader AN, Selleri L, Wang TL. Ovarian Cancer Chemoresistance Relies on the Stem Cell Reprogramming Factor PBX1. Cancer Res. 2016 11 01; 76(21):6351-6361. PMID: 27590741.
      View in: PubMed
    9. Hanley O, Zewdu R, Cohen LJ, Jung H, Lacombe J, Philippidou P, Lee DH, Selleri L, Dasen JS. Parallel Pbx-Dependent Pathways Govern the Coalescence and Fate of Motor Columns. Neuron. 2016 Sep 07; 91(5):1005-1020. PMID: 27568519; PMCID: PMC5017921 [Available on 09/07/17].
    10. Villaescusa JC, Li B, Toledo EM, Rivetti di Val Cervo P, Yang S, Stott SR, Kaiser K, Islam S, Gyllborg D, Laguna-Goya R, Landreh M, Lönnerberg P, Falk A, Bergman T, Barker RA, Linnarsson S, Selleri L, Arenas E. A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease. EMBO J. 2016 09 15; 35(18):1963-78. PMID: 27354364.
      View in: PubMed
    11. Brinkley JF, Fisher S, Harris MP, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Maas RL, Marazita ML, Selleri L, Spritz RA, van Bakel H, Visel A, Williams TJ, Wysocka J. The FaceBase Consortium: a comprehensive resource for craniofacial researchers. Development. 2016 07 15; 143(14):2677-88. PMID: 27287806; PMCID: PMC4958338.
    12. Grebbin BM, Hau AC, Groß A, Anders-Maurer M, Schramm J, Koss M, Wille C, Mittelbronn M, Selleri L, Schulte D. Pbx1 is required for adult subventricular zone neurogenesis. Development. 2016 07 01; 143(13):2281-91. PMID: 27226325; PMCID: PMC4958316 [Available on 07/01/17].
    13. Zewdu R, Risolino M, Barbulescu A, Ramalingam P, Butler JM, Selleri L. Spleen hypoplasia leads to abnormal stress hematopoiesis in mice with loss of Pbx homeoproteins in splenic mesenchyme. J Anat. 2016 07; 229(1):153-69. PMID: 27075259.
      View in: PubMed
    14. Golonzhka O, Nord A, Tang PLF, Lindtner S, Ypsilanti AR, Ferretti E, Visel A, Selleri L, Rubenstein JLR. Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic Neurons. Neuron. 2015 Dec 16; 88(6):1192-1207. PMID: 26671461.
      View in: PubMed
    15. Prescott SL, Srinivasan R, Marchetto MC, Grishina I, Narvaiza I, Selleri L, Gage FH, Swigut T, Wysocka J. Enhancer divergence and cis-regulatory evolution in the human and chimp neural crest. Cell. 2015 Sep 24; 163(1):68-83. PMID: 26365491; PMCID: PMC4848043.
    16. Hurtado R, Zewdu R, Mtui J, Liang C, Aho R, Kurylo C, Selleri L, Herzlinger D. Pbx1-dependent control of VMC differentiation kinetics underlies gross renal vascular patterning. Development. 2015 Aug 01; 142(15):2653-64. PMID: 26138478; PMCID: PMC4529034.
    17. Han YC, Vidigal JA, Mu P, Yao E, Singh I, González AJ, Concepcion CP, Bonetti C, Ogrodowski P, Carver B, Selleri L, Betel D, Leslie C, Ventura A. An allelic series of miR-17 ~ 92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron. Nat Genet. 2015 Jul; 47(7):766-75. PMID: 26029871; PMCID: PMC4485521.
    18. Vierstra J, Rynes E, Sandstrom R, Zhang M, Canfield T, Hansen RS, Stehling-Sun S, Sabo PJ, Byron R, Humbert R, Thurman RE, Johnson AK, Vong S, Lee K, Bates D, Neri F, Diegel M, Giste E, Haugen E, Dunn D, Wilken MS, Josefowicz S, Samstein R, Chang KH, Eichler EE, De Bruijn M, Reh TA, Skoultchi A, Rudensky A, Orkin SH, Papayannopoulou T, Treuting PM, Selleri L, Kaul R, Groudine M, Bender MA, Stamatoyannopoulos JA. Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution. Science. 2014 Nov 21; 346(6212):1007-12. PMID: 25411453; PMCID: PMC4337786.
    19. Yue F, Cheng Y, Breschi A, Vierstra J, Wu W, Ryba T, Sandstrom R, Ma Z, Davis C, Pope BD, Shen Y, Pervouchine DD, Djebali S, Thurman RE, Kaul R, Rynes E, Kirilusha A, Marinov GK, Williams BA, Trout D, Amrhein H, Fisher-Aylor K, Antoshechkin I, DeSalvo G, See LH, Fastuca M, Drenkow J, Zaleski C, Dobin A, Prieto P, Lagarde J, Bussotti G, Tanzer A, Denas O, Li K, Bender MA, Zhang M, Byron R, Groudine MT, McCleary D, Pham L, Ye Z, Kuan S, Edsall L, Wu YC, Rasmussen MD, Bansal MS, Kellis M, Keller CA, Morrissey CS, Mishra T, Jain D, Dogan N, Harris RS, Cayting P, Kawli T, Boyle AP, Euskirchen G, Kundaje A, Lin S, Lin Y, Jansen C, Malladi VS, Cline MS, Erickson DT, Kirkup VM, Learned K, Sloan CA, Rosenbloom KR, Lacerda de Sousa B, Beal K, Pignatelli M, Flicek P, Lian J, Kahveci T, Lee D, Kent WJ, Ramalho Santos M, Herrero J, Notredame C, Johnson A, Vong S, Lee K, Bates D, Neri F, Diegel M, Canfield T, Sabo PJ, Wilken MS, Reh TA, Giste E, Shafer A, Kutyavin T, Haugen E, Dunn D, Reynolds AP, Neph S, Humbert R, Hansen RS, De Bruijn M, Selleri L, Rudensky A, Josefowicz S, Samstein R, Eichler EE, Orkin SH, Levasseur D, Papayannopoulou T, Chang KH, Skoultchi A, Gosh S, Disteche C, Treuting P, Wang Y, Weiss MJ, Blobel GA, Cao X, Zhong S, Wang T, Good PJ, Lowdon RF, Adams LB, Zhou XQ, Pazin MJ, Feingold EA, Wold B, Taylor J, Mortazavi A, Weissman SM, Stamatoyannopoulos JA, Snyder MP, Guigo R, Gingeras TR, Gilbert DM, Hardison RC, Beer MA, Ren B. A comparative encyclopedia of DNA elements in the mouse genome. Nature. 2014 Nov 20; 515(7527):355-64. PMID: 25409824.
      View in: PubMed
    20. Cheng Y, Ma Z, Kim BH, Wu W, Cayting P, Boyle AP, Sundaram V, Xing X, Dogan N, Li J, Euskirchen G, Lin S, Lin Y, Visel A, Kawli T, Yang X, Patacsil D, Keller CA, Giardine B. Principles of regulatory information conservation between mouse and human. Nature. 2014 Nov 20; 515(7527):371-375. PMID: 25409826.
      View in: PubMed
    21. Handschuh K, Feenstra J, Koss M, Ferretti E, Risolino M, Zewdu R, Sahai MA, Bénazet JD, Peng XP, Depew MJ, Quintana L, Sharpe J, Wang B, Alcorn H, Rivi R, Butcher S, Manak JR, Vaccari T, Weinstein H, Anderson KV, Lacy E, Selleri L. ESCRT-II/Vps25 constrains digit number by endosome-mediated selective modulation of FGF-SHH signaling. Cell Rep. 2014 Oct 23; 9(2):674-87. PMID: 25373905; PMCID: PMC4223648.
    22. Li W, Lin CY, Shang C, Han P, Xiong Y, Lin CJ, Yang J, Selleri L, Chang CP. Pbx1 activates Fgf10 in the mesenchyme of developing lungs. Genesis. 2014 May; 52(5):399-407. PMID: 24591256.
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    23. Hall KC, Hill D, Otero M, Plumb DA, Froemel D, Dragomir CL, Maretzky T, Boskey A, Crawford HC, Selleri L, Goldring MB, Blobel CP. ADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes. Mol Cell Biol. 2013 Aug; 33(16):3077-90. PMID: 23732913; PMCID: PMC3753912.
    24. Bolze A, Mahlaoui N, Byun M, Turner B, Trede N, Ellis SR, Abhyankar A, Itan Y, Patin E, Brebner S, Sackstein P, Puel A, Picard C, Abel L, Quintana-Murci L, Faust SN, Williams AP, Baretto R, Duddridge M, Kini U, Pollard AJ, Gaud C, Frange P, Orbach D, Emile JF, Stephan JL, Sorensen R, Plebani A, Hammarstrom L, Conley ME, Selleri L, Casanova JL. Ribosomal protein SA haploinsufficiency in humans with isolated congenital asplenia. Science. 2013 May 24; 340(6135):976-8. PMID: 23579497; PMCID: PMC3677541.
    25. Feldhahn N, Ferretti E, Robbiani DF, Callen E, Deroubaix S, Selleri L, Nussenzweig A, Nussenzweig MC. The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo. EMBO J. 2012 Oct 17; 31(20):4045-56. PMID: 22940690; PMCID: PMC3474923.
    26. Koss M, Bolze A, Brendolan A, Saggese M, Capellini TD, Bojilova E, Boisson B, Prall OW, Elliott DA, Solloway M, Lenti E, Hidaka C, Chang CP, Mahlaoui N, Harvey RP, Casanova JL, Selleri L. Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module. Dev Cell. 2012 May 15; 22(5):913-26. PMID: 22560297; PMCID: PMC3356505.
    27. Ferretti E, Li B, Zewdu R, Wells V, Hebert JM, Karner C, Anderson MJ, Williams T, Dixon J, Dixon MJ, Depew MJ, Selleri L. A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis. Dev Cell. 2011 Oct 18; 21(4):627-41. PMID: 21982646; PMCID: PMC3199312.
    28. Gordon JA, Hassan MQ, Koss M, Montecino M, Selleri L, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Epigenetic regulation of early osteogenesis and mineralized tissue formation by a HOXA10-PBX1-associated complex. Cells Tissues Organs. 2011; 194(2-4):146-50. PMID: 21597276; PMCID: PMC3178072.
    29. Vitobello A, Ferretti E, Lampe X, Vilain N, Ducret S, Ori M, Spetz JF, Selleri L, Rijli FM. Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentation. Dev Cell. 2011 Apr 19; 20(4):469-82. PMID: 21497760; PMCID: PMC3677862.
    30. Capellini TD, Handschuh K, Quintana L, Ferretti E, Di Giacomo G, Fantini S, Vaccari G, Clarke SL, Wenger AM, Bejerano G, Sharpe J, Zappavigna V, Selleri L. Control of pelvic girdle development by genes of the Pbx family and Emx2. Dev Dyn. 2011 May; 240(5):1173-89. PMID: 21455939; PMCID: PMC3081414.
    31. Capellini TD, Zappavigna V, Selleri L. Pbx homeodomain proteins: TALEnted regulators of limb patterning and outgrowth. Dev Dyn. 2011 May; 240(5):1063-86. PMID: 21416555; PMCID: PMC3081394.
    32. Capellini TD, Vaccari G, Ferretti E, Fantini S, He M, Pellegrini M, Quintana L, Di Giacomo G, Sharpe J, Selleri L, Zappavigna V. Scapula development is governed by genetic interactions of Pbx1 with its family members and with Emx2 via their cooperative control of Alx1. Development. 2010 Aug 01; 137(15):2559-69. PMID: 20627960; PMCID: PMC2927673.
    33. Mercader N, Selleri L, Criado LM, Pallares P, Parras C, Cleary ML, Torres M. Ectopic Meis1 expression in the mouse limb bud alters P-D patterning in a Pbx1-independent manner. Int J Dev Biol. 2009; 53(8-10):1483-94. PMID: 19247936.
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    34. Capellini TD, Dunn MP, Passamaneck YJ, Selleri L, Di Gregorio A. Conservation of notochord gene expression across chordates: insights from the Leprecan gene family. Genesis. 2008 Nov; 46(11):683-96. PMID: 18798549; PMCID: PMC3065379.
    35. Stankunas K, Shang C, Twu KY, Kao SC, Jenkins NA, Copeland NG, Sanyal M, Selleri L, Cleary ML, Chang CP. Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease. Circ Res. 2008 Sep 26; 103(7):702-9. PMID: 18723445; PMCID: PMC2633052.
    36. Capellini TD, Zewdu R, Di Giacomo G, Asciutti S, Kugler JE, Di Gregorio A, Selleri L. Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome. Dev Biol. 2008 Sep 15; 321(2):500-14. PMID: 18691704.
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    37. Chung EY, Liu J, Homma Y, Zhang Y, Brendolan A, Saggese M, Han J, Silverstein R, Selleri L, Ma X. Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1. Immunity. 2007 Dec; 27(6):952-64. PMID: 18093541; PMCID: PMC2194654.
    38. Yeh N, Miller JP, Gaur T, Capellini TD, Nikolich-Zugich J, de la Hoz C, Selleri L, Bromage TG, van Wijnen AJ, Stein GS, Lian JB, Vidal A, Koff A. Cooperation between p27 and p107 during endochondral ossification suggests a genetic pathway controlled by p27 and p130. Mol Cell Biol. 2007 Jul; 27(14):5161-71. PMID: 17502351; PMCID: PMC1951950.
    39. Brendolan A, Rosado MM, Carsetti R, Selleri L, Dear TN. Development and function of the mammalian spleen. Bioessays. 2007 Feb; 29(2):166-77. PMID: 17226804.
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    40. Sanyal M, Tung JW, Karsunky H, Zeng H, Selleri L, Weissman IL, Herzenberg LA, Cleary ML. B-cell development fails in the absence of the Pbx1 proto-oncogene. Blood. 2007 May 15; 109(10):4191-9. PMID: 17244677; PMCID: PMC1885499.
    41. Ferretti E, Villaescusa JC, Di Rosa P, Fernandez-Diaz LC, Longobardi E, Mazzieri R, Miccio A, Micali N, Selleri L, Ferrari G, Blasi F. Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype. Mol Cell Biol. 2006 Aug; 26(15):5650-62. PMID: 16847320; PMCID: PMC1592771.
    42. Zhang X, Rowan S, Yue Y, Heaney S, Pan Y, Brendolan A, Selleri L, Maas RL. Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development. Dev Biol. 2006 Dec 15; 300(2):748-57. PMID: 17049510.
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    43. Capellini TD, Di Giacomo G, Salsi V, Brendolan A, Ferretti E, Srivastava D, Zappavigna V, Selleri L. Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression. Development. 2006 Jun; 133(11):2263-73. PMID: 16672333.
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    44. Moens CB, Selleri L. Hox cofactors in vertebrate development. Dev Biol. 2006 Mar 15; 291(2):193-206. PMID: 16515781.
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    45. Di Giacomo G, Koss M, Capellini TD, Brendolan A, Pöpperl H, Selleri L. Spatio-temporal expression of Pbx3 during mouse organogenesis. Gene Expr Patterns. 2006 Oct; 6(7):747-57. PMID: 16434237.
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    46. Brendolan A, Ferretti E, Salsi V, Moses K, Quaggin S, Blasi F, Cleary ML, Selleri L. A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny. Development. 2005 Jul; 132(13):3113-26. PMID: 15944191.
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    47. Manley NR, Selleri L, Brendolan A, Gordon J, Cleary ML. Abnormalities of caudal pharyngeal pouch development in Pbx1 knockout mice mimic loss of Hox3 paralogs. Dev Biol. 2004 Dec 15; 276(2):301-12. PMID: 15581866.
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    48. Rhee JW, Arata A, Selleri L, Jacobs Y, Arata S, Onimaru H, Cleary ML. Pbx3 deficiency results in central hypoventilation. Am J Pathol. 2004 Oct; 165(4):1343-50. PMID: 15466398; PMCID: PMC1618620.
    49. Selleri L, DiMartino J, van Deursen J, Brendolan A, Sanyal M, Boon E, Capellini T, Smith KS, Rhee J, Pöpperl H, Grosveld G, Cleary ML. The TALE homeodomain protein Pbx2 is not essential for development and long-term survival. Mol Cell Biol. 2004 Jun; 24(12):5324-31. PMID: 15169896; PMCID: PMC419882.
    50. Schnabel CA, Selleri L, Cleary ML. Pbx1 is essential for adrenal development and urogenital differentiation. Genesis. 2003 Nov; 37(3):123-30. PMID: 14595835.
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    51. Kim SK, Selleri L, Lee JS, Zhang AY, Gu X, Jacobs Y, Cleary ML. Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus. Nat Genet. 2002 Apr; 30(4):430-5. PMID: 11912494.
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    52. Wlodarska I, Selleri L, La Starza R, Paternotte C, Evans GA, Boogaerts M, Van den Berghe H, Mecucci C. Molecular cytogenetics localizes two new breakpoints on 11q23.3 and 21q11.2 in myelodysplastic syndrome with t(11;21) translocation. Genes Chromosomes Cancer. 1999 Mar; 24(3):199-206. PMID: 10451699.
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    53. Legius E, Wlodarska I, Selleri L, Evans GA, Wu R, Smet G, Fryns JP. De novo 46,XX, dir dup (11)(q133.3-->q14.2) in a patient with mental retardation, congenital cardiopathy and thrombopenia. Clin Genet. 1996 Apr; 49(4):206-10. PMID: 8828987.
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    54. Quackenbush J, Davies C, Bailis JM, Khristich JV, Diggle K, Marchuck Y, Tobin J, Clark SP, Rodkins A, Marcano S. An STS content map of human chromosome 11: localization of 910 YAC clones and 109 islands. Genomics. 1995 Sep 20; 29(2):512-25. PMID: 8666402.
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    55. Hernández JM, Mecucci C, Beverloo HB, Selleri L, Wlodarska I, Stul M, Michaux L, Verhoef G, Van Orshoven A, Cassiman JJ. Translocation (11;15)(q23;q14) in three patients with acute non-lymphoblastic leukemia (ANLL): clinical, cytogenetic and molecular studies. Leukemia. 1995 Jul; 9(7):1162-6. PMID: 7630191.
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    56. Luppi M, Morselli M, Emilia G, Temperani P, Marasca R, Barozzi P, Selleri L, Torelli G. Spontaneous loss of Ph chromosome with maintenance of clonal hemopoiesis in an untreated patient with myeloproliferative disease and a long survival. Genes Chromosomes Cancer. 1995 Mar; 12(3):237-40. PMID: 7536465.
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    57. Smith MW, Clark SP, Hutchinson JS, Wei YH, Churukian AC, Daniels LB, Diggle KL, Gen MW, Romo AJ, Lin Y. A sequence-tagged site map of human chromosome 11. Genomics. 1993 Sep; 17(3):699-725. PMID: 8244387.
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    58. Soekarman D, von Lindern M, van der Plas DC, Selleri L, Bartram CR, Martiat P, Culligan D, Padua RA, Hasper-Voogt KP, Hagemeijer A. Dek-can rearrangement in translocation (6;9)(p23;q34). Leukemia. 1992 Jun; 6(6):489-94. PMID: 1602786.
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    59. Selleri L, Hermanson GG, Eubanks JH, Evans GA. Chromosomal in situ hybridization using yeast artificial chromosomes. Genet Anal Tech Appl. 1991 Apr; 8(2):59-66. PMID: 2064820.
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    60. Ferrari S, Tagliafico E, D'Incá M, Ceccherelli G, Manfredini R, Selleri L, Donelli A, Sacchi S, Torelli G, Torelli U. Ratios between the abundance of messenger RNA and the corresponding protein of two growth-related genes, c-myc and vimentin, in leukemia blast cells. Cancer Res. 1990 Apr 01; 50(7):1988-91. PMID: 2180559.
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    61. Selleri L, Emilia G, Luppi M, Temperani P, Zucchini P, Tagliafico E, Artusi T, Sarti M, Donelli A, Castoldi GL. Chronic myelogenous leukemia with typical clinical and morphological features can be Philadelphia chromosome negative and "bcr negative". Hematol Pathol. 1990; 4(2):67-77. PMID: 2197265.
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    62. Selleri L, Emilia G, Temperani P, Grassilli E, Zucchini P, Tagliafico E, Bonati A, Venezia L, Ferrari S, Torelli U. Philadelphia-positive chronic myelogenous leukemia with typical bcr/abl molecular features and atypical, prolonged survival. Leukemia. 1989 Jul; 3(7):538-42. PMID: 2733455.
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    63. Ferrari S, Tagliafico E, Ceccherelli G, Selleri L, Calabretta B, Donelli A, Temperani P, Sarti M, Sacchi S, Emilia G. Expression of the myeloperoxidase gene in acute and chronic myeloid leukemias: relationship to the expression of cell cycle-related genes. Leukemia. 1989 Jun; 3(6):423-30. PMID: 2542700.
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    64. Emilia G, Temperani P, Ferrari S, Zucchini P, Tagliafico E, Selleri L, Torelli G, Artusi T, Torelli U. Cytogenetic and molecular studies in primary myelofibrosis. Cancer Genet Cytogenet. 1989 Mar; 38(1):101-13. PMID: 2713806.
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    65. Ferrari S, Calabretta B, Selleri L, Ceccherelli G, Torelli G, Torelli U. Expression of oncogenes and cell cycle related genes in acute and chronic leukemias. Leukemia. 1988 Dec; 2(12 Suppl):160S-166S. PMID: 3199878.
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    66. Venturelli D, Lange B, Narni F, Selleri L, Mariano MT, Torelli U, Gewirtz AM, Calabretta B. Prognostic significance of "short-term" effects of chemotherapy on MYC and histone H3 mRNA levels in acute leukemia patients. Proc Natl Acad Sci U S A. 1988 May; 85(10):3590-4. PMID: 3285345; PMCID: PMC280259.
    67. Torelli G, Venturelli D, Coló A, Zanni C, Selleri L, Moretti L, Calabretta B, Torelli U. Expression of c-myb protooncogene and other cell cycle-related genes in normal and neoplastic human colonic mucosa. Cancer Res. 1987 Oct 15; 47(20):5266-9. PMID: 3652034.
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    68. Torelli UL, Torelli GM, Emilia G, Selleri L, Venturelli D, Artusi T, Donelli A, Colò A, Fornieri C. Simultaneously increased expression of the c-myc and mu chain genes in the acute blastic transformation of a chronic lymphocytic leukaemia. Br J Haematol. 1987 Feb; 65(2):165-70. PMID: 3103669.
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    69. Calabretta B, Kaczmarek L, Selleri L, Torelli G, Ming PM, Ming SC, Mercer WE. Growth-dependent expression of human Mr 53,000 tumor antigen messenger RNA in normal and neoplastic cells. Cancer Res. 1986 Nov; 46(11):5738-42. PMID: 3019534.
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    70. Emilia G, Donelli A, Ferrari S, Torelli U, Selleri L, Zucchini P, Moretti L, Venturelli D, Ceccherelli G, Torelli G. Cellular levels of mRNA from c-myc, c-myb and c-fes onc-genes in normal myeloid and erythroid precursors of human bone marrow: an in situ hybridization study. Br J Haematol. 1986 Feb; 62(2):287-92. PMID: 3947550.
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    71. Torelli U, Selleri L, Venturelli D, Donelli A, Emilia G, Ceccherelli G, Turchi L, Torelli G. Differential patterns of expression of cell cycle-related genes in blast cells of acute myeloid leukemia. Leuk Res. 1986; 10(10):1249-54. PMID: 3464813.
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    72. Ferrari S, Torelli U, Selleri L, Donelli A, Venturelli D, Moretti L, Torelli G. Expression of human c-fes onc-gene occurs at detectable levels in myeloid but not in lymphoid cell populations. Br J Haematol. 1985 Jan; 59(1):21-5. PMID: 3855647.
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    73. Ferrari S, Torelli U, Selleri L, Donelli A, Venturelli D, Narni F, Moretti L, Torelli G. Study of the levels of expression of two oncogenes, c-myc and c-myb, in acute and chronic leukemias of both lymphoid and myeloid lineage. Leuk Res. 1985; 9(7):833-42. PMID: 3860696.
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