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Correction: Protein Phosphatase 2A as a Therapeutic Target in Small Cell Lung Cancer. Mol Cancer Ther. 2022 Apr 01; 21(4):700.
Mirzapoiazova T, Xiao G, Mambetsariev B, Nasser MW, Miaou E, Singhal SS, Srivastava S, Mambetsariev I, Nelson MS, Nam A, Behal A, Arvanitis LD, Atri P, Muschen M, Tissot FLH, Miser J, Kovach JS, Sattler M, Batra SK, Kulkarni P, Salgia R. PMID: 35373301; PMCID: PMC10996841.
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Protein Phosphatase 2A as a Therapeutic Target in Small Cell Lung Cancer. Mol Cancer Ther. 2021 10; 20(10):1820-1835.
Mirzapoiazova T, Xiao G, Mambetsariev B, Nasser MW, Miaou E, Singhal SS, Srivastava S, Mambetsariev I, Nelson MS, Nam A, Behal A, Arvanitis LD, Atri P, Muschen M, Tissot FLH, Miser J, Kovach JS, Sattler M, Batra SK, Kulkarni P, Salgia R. PMID: 34253596; PMCID: PMC8722383.
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7 Fields:
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HumansCells
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IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia. Blood. 2020 09 24; 136(13):1520-1534.
Song C, Ge Z, Ding Y, Tan BH, Desai D, Gowda K, Amin S, Gowda R, Robertson GP, Yue F, Huang S, Spiegelman V, Payne JL, Reeves ME, Gurel Z, Iyer S, Dhanyamraju PK, Xiang M, Kawasawa YI, Cury NM, Yunes JA, McGrath M, Schramm J, Su R, Yang Y, Zhao Z, Lyu X, Muschen M, Payne KJ, Gowda C, Dovat S. PMID: 32396934; PMCID: PMC7515690.
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24 Fields:
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HumansAnimalsCells
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Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease. Nat Commun. 2017 10 17; 8(1):978.
Deng R, Hurtz C, Song Q, Yue C, Xiao G, Yu H, Wu X, Muschen M, Forman S, Martin PJ, Zeng D. PMID: 29042531; PMCID: PMC5645449.
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45 Fields:
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HumansAnimalsCells
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Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells. J Clin Invest. 2017 Jun 01; 127(6):2392-2406.
Nieborowska-Skorska M, Sullivan K, Dasgupta Y, Podszywalow-Bartnicka P, Hoser G, Maifrede S, Martinez E, Di Marcantonio D, Bolton-Gillespie E, Cramer-Morales K, Lee J, Li M, Slupianek A, Gritsyuk D, Cerny-Reiterer S, Seferynska I, Stoklosa T, Bullinger L, Zhao H, Gorbunova V, Piwocka K, Valent P, Civin CI, Muschen M, Dick JE, Wang JC, Bhatia S, Bhatia R, Eppert K, Minden MD, Sykes SM, Skorski T. PMID: 28481221; PMCID: PMC5451241.
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48 Fields:
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HumansAnimalsCells
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The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 2016 07 11; 30(1):183.
Townsend EC, Murakami MA, Christodoulou A, Christie AL, Köster J, DeSouza TA, Morgan EA, Kallgren SP, Liu H, Wu SC, Plana O, Montero J, Stevenson KE, Rao P, Vadhi R, Andreeff M, Armand P, Ballen KK, Barzaghi-Rinaudo P, Cahill S, Clark RA, Cooke VG, Davids MS, DeAngelo DJ, Dorfman DM, Eaton H, Ebert BL, Etchin J, Firestone B, Fisher DC, Freedman AS, Galinsky IA, Gao H, Garcia JS, Garnache-Ottou F, Graubert TA, Gutierrez A, Halilovic E, Harris MH, Herbert ZT, Horwitz SM, Inghirami G, Intlekofer AM, Ito M, Izraeli S, Jacobsen ED, Jacobson CA, Jeay S, Jeremias I, Kelliher MA, Koch R, Konopleva M, Kopp N, Kornblau SM, Kung AL, Kupper TS, LeBoeuf NR, LaCasce AS, Lees E, Li LS, Look AT, Murakami M, Muschen M, Neuberg D, Ng SY, Odejide OO, Orkin SH, Paquette RR, Place AE, Roderick JE, Ryan JA, Sallan SE, Shoji B, Silverman LB, Soiffer RJ, Steensma DP, Stegmaier K, Stone RM, Tamburini J, Thorner AR, van Hummelen P, Wadleigh M, Wiesmann M, Weng AP, Wuerthner JU, Williams DA, Wollison BM, Lane AA, Letai A, Bertagnolli MM, Ritz J, Brown M, Long H, Aster JC, Shipp MA, Griffin JD, Weinstock DM. PMID: 27479034.
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39 Fields:
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The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 2016 04 11; 29(4):574-586.
Townsend EC, Murakami MA, Christodoulou A, Christie AL, Köster J, DeSouza TA, Morgan EA, Kallgren SP, Liu H, Wu SC, Plana O, Montero J, Stevenson KE, Rao P, Vadhi R, Andreeff M, Armand P, Ballen KK, Barzaghi-Rinaudo P, Cahill S, Clark RA, Cooke VG, Davids MS, DeAngelo DJ, Dorfman DM, Eaton H, Ebert BL, Etchin J, Firestone B, Fisher DC, Freedman AS, Galinsky IA, Gao H, Garcia JS, Garnache-Ottou F, Graubert TA, Gutierrez A, Halilovic E, Harris MH, Herbert ZT, Horwitz SM, Inghirami G, Intlekofer AM, Ito M, Izraeli S, Jacobsen ED, Jacobson CA, Jeay S, Jeremias I, Kelliher MA, Koch R, Konopleva M, Kopp N, Kornblau SM, Kung AL, Kupper TS, LeBoeuf NR, LaCasce AS, Lees E, Li LS, Look AT, Murakami M, Muschen M, Neuberg D, Ng SY, Odejide OO, Orkin SH, Paquette RR, Place AE, Roderick JE, Ryan JA, Sallan SE, Shoji B, Silverman LB, Soiffer RJ, Steensma DP, Stegmaier K, Stone RM, Tamburini J, Thorner AR, van Hummelen P, Wadleigh M, Wiesmann M, Weng AP, Wuerthner JU, Williams DA, Wollison BM, Lane AA, Letai A, Bertagnolli MM, Ritz J, Brown M, Long H, Aster JC, Shipp MA, Griffin JD, Weinstock DM. PMID: 27070704; PMCID: PMC5177991.
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147 Fields:
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HumansAnimalsCells
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Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia. Oncotarget. 2016 Apr 05; 7(14):18736-49.
Sun H, Lin DC, Guo X, Kharabi Masouleh B, Gery S, Cao Q, Alkan S, Ikezoe T, Akiba C, Paquette R, Chien W, Müller-Tidow C, Jing Y, Agelopoulos K, Müschen M, Koeffler HP. PMID: 26934650; PMCID: PMC4951325.
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47 Fields:
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HumansAnimalsCells
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PTEN opposes negative selection and enables oncogenic transformation of pre-B cells. Nat Med. 2016 Apr; 22(4):379-87.
Shojaee S, Chan LN, Buchner M, Cazzaniga V, Cosgun KN, Geng H, Qiu YH, von Minden MD, Ernst T, Hochhaus A, Cazzaniga G, Melnick A, Kornblau SM, Graeber TG, Wu H, Jumaa H, Müschen M. PMID: 26974310; PMCID: PMC5178869.
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61 Fields:
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HumansAnimalsCells
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Normal ABL1 is a tumor suppressor and therapeutic target in human and mouse leukemias expressing oncogenic ABL1 kinases. Blood. 2016 04 28; 127(17):2131-43.
Dasgupta Y, Koptyra M, Hoser G, Kantekure K, Roy D, Gornicka B, Nieborowska-Skorska M, Bolton-Gillespie E, Cerny-Reiterer S, Müschen M, Valent P, Wasik MA, Richardson C, Hantschel O, van der Kuip H, Stoklosa T, Skorski T. PMID: 26864341; PMCID: PMC4850868.
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16 Fields:
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HumansAnimalsCells
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Pre-BCR signaling in precursor B-cell acute lymphoblastic leukemia regulates PI3K/AKT, FOXO1 and MYC, and can be targeted by SYK inhibition. Leukemia. 2016 06; 30(6):1246-54.
Köhrer S, Havranek O, Seyfried F, Hurtz C, Coffey GP, Kim E, Ten Hacken E, Jäger U, Vanura K, O'Brien S, Thomas DA, Kantarjian H, Ghosh D, Wang Z, Zhang M, Ma W, Jumaa H, Debatin KM, Müschen M, Meyer LH, Davis RE, Burger JA. PMID: 26847027; PMCID: PMC5459356.
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45 Fields:
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HumansAnimalsCells
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BCOR regulates myeloid cell proliferation and differentiation. Leukemia. 2016 05; 30(5):1155-65.
Cao Q, Gearhart MD, Gery S, Shojaee S, Yang H, Sun H, Lin DC, Bai JW, Mead M, Zhao Z, Chen Q, Chien WW, Alkan S, Alpermann T, Haferlach T, Müschen M, Bardwell VJ, Koeffler HP. PMID: 26847029; PMCID: PMC5131645.
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47 Fields:
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HumansAnimalsCells
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MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199. Cell Rep. 2015 Dec 29; 13(12):2715-27.
Benito JM, Godfrey L, Kojima K, Hogdal L, Wunderlich M, Geng H, Marzo I, Harutyunyan KG, Golfman L, North P, Kerry J, Ballabio E, Chonghaile TN, Gonzalo O, Qiu Y, Jeremias I, Debose L, O'Brien E, Ma H, Zhou P, Jacamo R, Park E, Coombes KR, Zhang N, Thomas DA, O'Brien S, Kantarjian HM, Leverson JD, Kornblau SM, Andreeff M, Müschen M, Zweidler-McKay PA, Mulloy JC, Letai A, Milne TA, Konopleva M. PMID: 26711339; PMCID: PMC4700051.
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68 Fields:
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HumansAnimalsCells
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Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia. Leukemia. 2016 06; 30(6):1436-40.
Song C, Pan X, Ge Z, Gowda C, Ding Y, Li H, Li Z, Yochum G, Muschen M, Li Q, Payne KJ, Dovat S. PMID: 26639180; PMCID: PMC4889471.
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34 Fields:
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Humans
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Infection and the Perils of B-cell Activation. Cancer Discov. 2015 Dec; 5(12):1244-6.
Greaves M, Müschen M. PMID: 26637659; PMCID: PMC4758198.
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4 Fields:
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HumansCells
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MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia. Blood. 2015 Nov 05; 126(19):2202-12.
Jones CL, Gearheart CM, Fosmire S, Delgado-Martin C, Evensen NA, Bride K, Waanders AJ, Pais F, Wang J, Bhatla T, Bitterman DS, de Rijk SR, Bourgeois W, Dandekar S, Park E, Burleson TM, Madhusoodhan PP, Teachey DT, Raetz EA, Hermiston ML, Müschen M, Loh ML, Hunger SP, Zhang J, Garabedian MJ, Porter CC, Carroll WL. PMID: 26324703; PMCID: PMC4635116.
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Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia. Blood. 2015 Oct 08; 126(15):1813-22.
Song C, Gowda C, Pan X, Ding Y, Tong Y, Tan BH, Wang H, Muthusami S, Ge Z, Sachdev M, Amin SG, Desai D, Gowda K, Gowda R, Robertson GP, Schjerven H, Muschen M, Payne KJ, Dovat S. PMID: 26219304; PMCID: PMC4600018.
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59 Fields:
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HumansAnimalsCells
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Infectious origins of childhood leukemia. Oncotarget. 2015 Jul 10; 6(19):16798-9.
Swaminathan S, Müschen M. PMID: 26196452; PMCID: PMC4627260.
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2 Fields:
Translation:
HumansAnimals
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Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia. Cancer Cell. 2015 Jul 13; 28(1):114-28.
Shojaee S, Caeser R, Buchner M, Park E, Swaminathan S, Hurtz C, Geng H, Chan LN, Klemm L, Hofmann WK, Qiu YH, Zhang N, Coombes KR, Paietta E, Molkentin J, Koeffler HP, Willman CL, Hunger SP, Melnick A, Kornblau SM, Müschen M. PMID: 26073130; PMCID: PMC4565502.
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66 Fields:
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HumansAnimalsCells
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HSP90 inhibitors decrease AID levels and activity in mice and in human cells. Eur J Immunol. 2015 Aug; 45(8):2365-76.
Montamat-Sicotte D, Litzler LC, Abreu C, Safavi S, Zahn A, Orthwein A, Müschen M, Oppezzo P, Muñoz DP, Di Noia JM. PMID: 25912253; PMCID: PMC4536124.
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11 Fields:
Translation:
HumansAnimalsCells
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Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia. Nat Immunol. 2015 Jul; 16(7):766-774.
Swaminathan S, Klemm L, Park E, Papaemmanuil E, Ford A, Kweon SM, Trageser D, Hasselfeld B, Henke N, Mooster J, Geng H, Schwarz K, Kogan SC, Casellas R, Schatz DG, Lieber MR, Greaves MF, Müschen M. PMID: 25985233; PMCID: PMC4475638.
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106 Fields:
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HumansAnimalsCells
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Ph+ ALL: drawing strength from a benign past. Blood. 2015 May 07; 125(19):2879-80.
Müschen M. PMID: 25953975; PMCID: PMC4424411.
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1 Fields:
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AnimalsCells
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YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway. J Hematol Oncol. 2015 Apr 22; 8:39.
Chang BH, Johnson K, LaTocha D, Rowley JS, Bryant J, Burke R, Smith RL, Loriaux M, Müschen M, Mullighan C, Druker BJ, Tyner JW. PMID: 25895498; PMCID: PMC4408565.
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17 Fields:
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HumansCells
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Rationale for targeting the pre-B-cell receptor signaling pathway in acute lymphoblastic leukemia. Blood. 2015 Jun 11; 125(24):3688-93.
Müschen M. PMID: 25878119; PMCID: PMC4463734.
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22 Fields:
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HumansCells
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Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2015 May 21; 521(7552):357-61.
Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M. PMID: 25799995; PMCID: PMC4441554.
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PubMed Mentions:
80 Fields:
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HumansAnimalsCells
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Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia. Nat Commun. 2015 Mar 10; 6:6471.
Buchner M, Park E, Geng H, Klemm L, Flach J, Passegué E, Schjerven H, Melnick A, Paietta E, Kopanja D, Raychaudhuri P, Müschen M. PMID: 25753524; PMCID: PMC4366523.
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PubMed Mentions:
31 Fields:
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HumansAnimalsCells
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Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia. Cancer Cell. 2015 Mar 09; 27(3):409-25.
Geng H, Hurtz C, Lenz KB, Chen Z, Baumjohann D, Thompson S, Goloviznina NA, Chen WY, Huan J, LaTocha D, Ballabio E, Xiao G, Lee JW, Deucher A, Qi Z, Park E, Huang C, Nahar R, Kweon SM, Shojaee S, Chan LN, Yu J, Kornblau SM, Bijl JJ, Ye BH, Ansel KM, Paietta E, Melnick A, Hunger SP, Kurre P, Tyner JW, Loh ML, Roeder RG, Druker BJ, Burger JA, Milne TA, Chang BH, Müschen M. PMID: 25759025; PMCID: PMC4618684.
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PubMed Mentions:
77 Fields:
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HumansCells
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Human lymphoid translocation fragile zones are hypomethylated and have accessible chromatin. Mol Cell Biol. 2015 Apr; 35(7):1209-22.
Lu Z, Lieber MR, Tsai AG, Pardo CE, Müschen M, Kladde MP, Hsieh CL. PMID: 25624348; PMCID: PMC4355534.
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PubMed Mentions:
9 Fields:
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HumansCells
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Mechanisms of pre-B-cell receptor checkpoint control and its oncogenic subversion in acute lymphoblastic leukemia. Immunol Rev. 2015 Jan; 263(1):192-209.
Buchner M, Swaminathan S, Chen Z, Müschen M. PMID: 25510278.
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23 Fields:
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HumansAnimalsCells
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Follicular lymphoma: too many reminders for a memory B cell. J Clin Invest. 2014 Dec; 124(12):5095-8.
Swaminathan S, Müschen M. PMID: 25384212; PMCID: PMC4348960.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Identification and characterization of OSTL (RNF217) encoding a RING-IBR-RING protein adjacent to a translocation breakpoint involving ETV6 in childhood ALL. Sci Rep. 2014 Oct 09; 4:6565.
Fontanari Krause LM, Japp AS, Krause A, Mooster J, Chopra M, Müschen M, Bohlander SK. PMID: 25298122; PMCID: PMC4190505.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Targeting the B-cell receptor signaling pathway in B lymphoid malignancies. Curr Opin Hematol. 2014 Jul; 21(4):341-9.
Buchner M, Müschen M. PMID: 24811161; PMCID: PMC4136419.
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27 Fields:
Translation:
HumansAnimalsCells
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Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):E2219-28.
Kharabi Masouleh B, Geng H, Hurtz C, Chan LN, Logan AC, Chang MS, Huang C, Swaminathan S, Sun H, Paietta E, Melnick AM, Koeffler P, Müschen M. PMID: 24821775; PMCID: PMC4040579.
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PubMed Mentions:
52 Fields:
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HumansAnimalsCells
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AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine. Oncotarget. 2014 Jan 15; 5(1):211-23.
Tsai CT, Yang PM, Chern TR, Chuang SH, Lin JH, Klemm L, Müschen M, Chen CC. PMID: 24457556; PMCID: PMC3960202.
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8 Fields:
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HumansAnimalsCells
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RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia. Nat Genet. 2014 Feb; 46(2):116-25.
Papaemmanuil E, Rapado I, Li Y, Potter NE, Wedge DC, Tubio J, Alexandrov LB, Van Loo P, Cooke SL, Marshall J, Martincorena I, Hinton J, Gundem G, van Delft FW, Nik-Zainal S, Jones DR, Ramakrishna M, Titley I, Stebbings L, Leroy C, Menzies A, Gamble J, Robinson B, Mudie L, Raine K, O'Meara S, Teague JW, Butler AP, Cazzaniga G, Biondi A, Zuna J, Kempski H, Muschen M, Ford AM, Stratton MR, Greaves M, Campbell PJ. PMID: 24413735; PMCID: PMC3960636.
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PubMed Mentions:
210 Fields:
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HumansCells
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Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia. Cancer Discov. 2014 Mar; 4(3):362-75.
Pan R, Hogdal LJ, Benito JM, Bucci D, Han L, Borthakur G, Cortes J, DeAngelo DJ, Debose L, Mu H, Döhner H, Gaidzik VI, Galinsky I, Golfman LS, Haferlach T, Harutyunyan KG, Hu J, Leverson JD, Marcucci G, Müschen M, Newman R, Park E, Ruvolo PP, Ruvolo V, Ryan J, Schindela S, Zweidler-McKay P, Stone RM, Kantarjian H, Andreeff M, Konopleva M, Letai AG. PMID: 24346116; PMCID: PMC3975047.
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372 Fields:
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HumansAnimalsCells
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BACH2-BCL6 balance regulates selection at the pre-B cell receptor checkpoint. Trends Immunol. 2014 Mar; 35(3):131-7.
Swaminathan S, Duy C, Müschen M. PMID: 24332591; PMCID: PMC3943645.
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21 Fields:
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HumansAnimalsCells
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VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia. Leukemia. 2014 Jan; 28(1):216-20.
Mangum DS, Downie J, Mason CC, Jahromi MS, Joshi D, Rodic V, Müschen M, Meeker N, Trede N, Frazer JK, Zhou Y, Cheng C, Jeha S, Pui CH, Willman CL, Harvey RC, Hunger SP, Yang JJ, Barnette P, Mullighan CG, Miles RR, Schiffman JD. PMID: 23881307; PMCID: PMC4043450.
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15 Fields:
Translation:
Humans
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BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint. Nat Med. 2013 Aug; 19(8):1014-22.
Swaminathan S, Huang C, Geng H, Chen Z, Harvey R, Kang H, Ng C, Titz B, Hurtz C, Sadiyah MF, Nowak D, Thoennissen GB, Rand V, Graeber TG, Koeffler HP, Carroll WL, Willman CL, Hall AG, Igarashi K, Melnick A, Müschen M. PMID: 23852341; PMCID: PMC3954721.
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PubMed Mentions:
59 Fields:
Translation:
AnimalsCells
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Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile. Blood. 2013 Aug 15; 122(7):1293-304.
Cramer-Morales K, Nieborowska-Skorska M, Scheibner K, Padget M, Irvine DA, Sliwinski T, Haas K, Lee J, Geng H, Roy D, Slupianek A, Rassool FV, Wasik MA, Childers W, Copland M, Müschen M, Civin CI, Skorski T. PMID: 23836560; PMCID: PMC3744994.
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PubMed Mentions:
88 Fields:
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HumansAnimalsCells
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Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia. Oncogene. 2014 Apr 24; 33(17):2169-78.
Gang EJ, Hsieh YT, Pham J, Zhao Y, Nguyen C, Huantes S, Park E, Naing K, Klemm L, Swaminathan S, Conway EM, Pelus LM, Crispino J, Mullighan CG, McMillan M, Müschen M, Kahn M, Kim YM. PMID: 23728349; PMCID: PMC3994178.
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100 Fields:
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HumansAnimalsCells
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O-acetylated N-acetylneuraminic acid as a novel target for therapy in human pre-B acute lymphoblastic leukemia. J Exp Med. 2013 Apr 08; 210(4):805-19.
Parameswaran R, Lim M, Arutyunyan A, Abdel-Azim H, Hurtz C, Lau K, Müschen M, Yu RK, von Itzstein M, Heisterkamp N, Groffen J. PMID: 23478187; PMCID: PMC3620349.
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Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy. Blood. 2013 Mar 07; 121(10):1814-8.
Hsieh YT, Gang EJ, Geng H, Park E, Huantes S, Chudziak D, Dauber K, Schaefer P, Scharman C, Shimada H, Shojaee S, Klemm L, Parameswaran R, Loh M, Kang ES, Koo HH, Hofmann WK, Andrade J, Crooks GM, Willman CL, Müschen M, Papayannopoulou T, Heisterkamp N, Bönig H, Kim YM. PMID: 23319569; PMCID: PMC3591800.
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71 Fields:
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HumansAnimalsCells
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Both CpG methylation and activation-induced deaminase are required for the fragility of the human bcl-2 major breakpoint region: implications for the timing of the breaks in the t(14;18) translocation. Mol Cell Biol. 2013 Mar; 33(5):947-57.
Cui X, Lu Z, Kurosawa A, Klemm L, Bagshaw AT, Tsai AG, Gemmell N, Müschen M, Adachi N, Hsieh CL, Lieber MR. PMID: 23263985; PMCID: PMC3623081.
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PubMed Mentions:
21 Fields:
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HumansCells
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SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia. Blood. 2013 Jan 03; 121(1):148-55.
Ramezani-Rad P, Geng H, Hurtz C, Chan LN, Chen Z, Jumaa H, Melnick A, Paietta E, Carroll WL, Willman CL, Lefebvre V, Müschen M. PMID: 23152540; PMCID: PMC3538327.
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PubMed Mentions:
45 Fields:
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HumansAnimalsCells
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Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia. Cancer Cell. 2012 Nov 13; 22(5):656-67.
Bicocca VT, Chang BH, Masouleh BK, Muschen M, Loriaux MM, Druker BJ, Tyner JW. PMID: 23153538; PMCID: PMC3500515.
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PubMed Mentions:
97 Fields:
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HumansCells
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Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia. Cancer Discov. 2012 Nov; 2(11):1004-23.
Geng H, Brennan S, Milne TA, Chen WY, Li Y, Hurtz C, Kweon SM, Zickl L, Shojaee S, Neuberg D, Huang C, Biswas D, Xin Y, Racevskis J, Ketterling RP, Luger SM, Lazarus H, Tallman MS, Rowe JM, Litzow MR, Guzman ML, Allis CD, Roeder RG, Müschen M, Paietta E, Elemento O, Melnick AM. PMID: 23107779; PMCID: PMC3516186.
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PubMed Mentions:
51 Fields:
Translation:
HumansCells
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IKAROS deletions dictate a unique gene expression signature in patients with adult B-cell acute lymphoblastic leukemia. PLoS One. 2012; 7(7):e40934.
Iacobucci I, Iraci N, Messina M, Lonetti A, Chiaretti S, Valli E, Ferrari A, Papayannidis C, Paoloni F, Vitale A, Storlazzi CT, Ottaviani E, Guadagnuolo V, Durante S, Vignetti M, Soverini S, Pane F, Foà R, Baccarani M, Müschen M, Perini G, Martinelli G. PMID: 22848414; PMCID: PMC3405023.
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PubMed Mentions:
43 Fields:
Translation:
HumansCellsCTClinical Trials
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Zebrafish screen identifies novel compound with selective toxicity against leukemia. Blood. 2012 Jun 14; 119(24):5621-31.
Ridges S, Heaton WL, Joshi D, Choi H, Eiring A, Batchelor L, Choudhry P, Manos EJ, Sofla H, Sanati A, Welborn S, Agarwal A, Spangrude GJ, Miles RR, Cox JE, Frazer JK, Deininger M, Balan K, Sigman M, Müschen M, Perova T, Johnson R, Montpellier B, Guidos CJ, Jones DA, Trede NS. PMID: 22490804; PMCID: PMC3382926.
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PubMed Mentions:
84 Fields:
Translation:
HumansAnimalsCells
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Control of B cell development by the histone H2A deubiquitinase MYSM1. Immunity. 2011 Dec 23; 35(6):883-96.
Jiang XX, Nguyen Q, Chou Y, Wang T, Nandakumar V, Yates P, Jones L, Wang L, Won H, Lee HR, Jung JU, Müschen M, Huang XF, Chen SY. PMID: 22169041; PMCID: PMC4098839.
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PubMed Mentions:
48 Fields:
Translation:
AnimalsCells
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BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia. J Exp Med. 2011 Oct 24; 208(11):2163-74.
Hurtz C, Hatzi K, Cerchietti L, Braig M, Park E, Kim YM, Herzog S, Ramezani-Rad P, Jumaa H, Müller MC, Hofmann WK, Hochhaus A, Ye BH, Agarwal A, Druker BJ, Shah NP, Melnick AM, Müschen M. PMID: 21911423; PMCID: PMC3201200.
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PubMed Mentions:
97 Fields:
Translation:
HumansAnimalsCells
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Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC. Blood. 2011 Oct 13; 118(15):4174-8.
Nahar R, Ramezani-Rad P, Mossner M, Duy C, Cerchietti L, Geng H, Dovat S, Jumaa H, Ye BH, Melnick A, Müschen M. PMID: 21856866; PMCID: PMC3204735.
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PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
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Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia. Blood. 2011 Aug 25; 118(8):2191-9.
Park E, Gang EJ, Hsieh YT, Schaefer P, Chae S, Klemm L, Huantes S, Loh M, Conway EM, Kang ES, Hoe Koo H, Hofmann WK, Heisterkamp N, Pelus L, Keerthivasan G, Crispino J, Kahn M, Müschen M, Kim YM. PMID: 21715311; PMCID: PMC3162353.
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PubMed Mentions:
59 Fields:
Translation:
HumansAnimals
-
American Journal of Blood Research: Editorial Board (2011) e-Century Publishing Corporation. Am J Blood Res. 2011; 1(1):106-9.
Kwak LW, Goldenberg DM, Benz EJ, Yi Q, Müschen M, Wang D. PMID: 22432071; PMCID: PMC3301414.
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PubMed Mentions:
-
Launching of american journal of blood research. Am J Blood Res. 2011; 1(1):i.
Kwak LW, Goldenberg DM, Benz EJ, Yi Q, Muschen M, Wang D. PMID: 22432072; PMCID: PMC3301420.
View in:
PubMed Mentions:
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BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. Nature. 2011 May 19; 473(7347):384-8.
Duy C, Hurtz C, Shojaee S, Cerchietti L, Geng H, Swaminathan S, Klemm L, Kweon SM, Nahar R, Braig M, Park E, Kim YM, Hofmann WK, Herzog S, Jumaa H, Koeffler HP, Yu JJ, Heisterkamp N, Graeber TG, Wu H, Ye BH, Melnick A, Müschen M. PMID: 21593872; PMCID: PMC3597744.
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PubMed Mentions:
118 Fields:
Translation:
HumansAnimalsCells
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HDAC inhibitors potentiate the activity of the BCR/ABL kinase inhibitor KW-2449 in imatinib-sensitive or -resistant BCR/ABL+ leukemia cells in vitro and in vivo. Clin Cancer Res. 2011 May 15; 17(10):3219-32.
Nguyen T, Dai Y, Attkisson E, Kramer L, Jordan N, Nguyen N, Kolluri N, Muschen M, Grant S. PMID: 21474579; PMCID: PMC3096723.
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PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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Global phosphoproteomics reveals crosstalk between Bcr-Abl and negative feedback mechanisms controlling Src signaling. Sci Signal. 2011 Mar 29; 4(166):ra18.
Rubbi L, Titz B, Brown L, Galvan E, Komisopoulou E, Chen SS, Low T, Tahmasian M, Skaggs B, Müschen M, Pellegrini M, Graeber TG. PMID: 21447799; PMCID: PMC4057100.
View in:
PubMed Mentions:
30 Fields:
Translation:
HumansCells
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ABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1. Leukemia. 2011 Feb; 25(2):290-300.
Thai M, Ting PY, McLaughlin J, Cheng D, Müschen M, Witte ON, Colicelli J. PMID: 21102429; PMCID: PMC3049868.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Activation-induced cytidine deaminase accelerates clonal evolution in BCR-ABL1-driven B-cell lineage acute lymphoblastic leukemia. Cancer Res. 2010 Oct 01; 70(19):7411-20.
Gruber TA, Chang MS, Sposto R, Müschen M. PMID: 20876806; PMCID: PMC2948648.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
-
Integrated microfluidic and imaging platform for a kinase activity radioassay to analyze minute patient cancer samples. Cancer Res. 2010 Nov 01; 70(21):8299-308.
Fang C, Wang Y, Vu NT, Lin WY, Hsieh YT, Rubbi L, Phelps ME, Müschen M, Kim YM, Chatziioannou AF, Tseng HR, Graeber TG. PMID: 20837665; PMCID: PMC3989903.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Diet-induced obesity accelerates acute lymphoblastic leukemia progression in two murine models. Cancer Prev Res (Phila). 2010 Oct; 3(10):1259-64.
Yun JP, Behan JW, Heisterkamp N, Butturini A, Klemm L, Ji L, Groffen J, Müschen M, Mittelman SD. PMID: 20823291; PMCID: PMC2955776.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimals
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BCL6 is critical for the development of a diverse primary B cell repertoire. J Exp Med. 2010 Jun 07; 207(6):1209-21.
Duy C, Yu JJ, Nahar R, Swaminathan S, Kweon SM, Polo JM, Valls E, Klemm L, Shojaee S, Cerchietti L, Schuh W, Jäck HM, Hurtz C, Ramezani-Rad P, Herzog S, Jumaa H, Koeffler HP, de Alborán IM, Melnick AM, Ye BH, Müschen M. PMID: 20498019; PMCID: PMC2882829.
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PubMed Mentions:
68 Fields:
Translation:
HumansAnimalsCells
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A functional receptor for B-cell-activating factor is expressed on human acute lymphoblastic leukemias. Cancer Res. 2010 Jun 01; 70(11):4346-56.
Parameswaran R, Müschen M, Kim YM, Groffen J, Heisterkamp N. PMID: 20460528; PMCID: PMC2880197.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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Genetic relicts from the origin of ALL. Blood. 2010 Apr 29; 115(17):3424-5.
Müschen M. PMID: 20430963.
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PubMed Mentions:
1 Fields:
-
Identification and functional relevance of de novo DNA methylation in cancerous B-cell populations. J Cell Biochem. 2010 Mar 01; 109(4):818-27.
Wang XM, Greiner TC, Bibikova M, Pike BL, Siegmund KD, Sinha UK, Müschen M, Jaeger EB, Weisenburger DD, Chan WC, Shibata D, Fan JB, Hacia JG. PMID: 20069569; PMCID: PMC3122883.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Development of resistance to dasatinib in Bcr/Abl-positive acute lymphoblastic leukemia. Leukemia. 2010 Apr; 24(4):813-20.
Fei F, Stoddart S, Müschen M, Kim YM, Groffen J, Heisterkamp N. PMID: 20111071; PMCID: PMC3038787.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Pre-B cell receptor signaling in acute lymphoblastic leukemia. Cell Cycle. 2009 Dec; 8(23):3874-7.
Nahar R, Müschen M. PMID: 19901533; PMCID: PMC4047560.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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SNP array analysis of tyrosine kinase inhibitor-resistant chronic myeloid leukemia identifies heterogeneous secondary genomic alterations. Blood. 2010 Feb 04; 115(5):1049-53.
Nowak D, Ogawa S, Müschen M, Kato M, Kawamata N, Meixel A, Nowak V, Kim HS, Kang S, Paquette R, Chang MS, Thoennissen NH, Thoenissen NH, Mossner M, Hofmann WK, Kohlmann A, Weiss T, Haferlach T, Haferlach C, Koeffler HP. PMID: 19965645; PMCID: PMC2817631.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia. Cancer Cell. 2009 Sep 08; 16(3):232-45.
Klemm L, Duy C, Iacobucci I, Kuchen S, von Levetzow G, Feldhahn N, Henke N, Li Z, Hoffmann TK, Kim YM, Hofmann WK, Jumaa H, Groffen J, Heisterkamp N, Martinelli G, Lieber MR, Casellas R, Müschen M. PMID: 19732723; PMCID: PMC2931825.
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PubMed Mentions:
74 Fields:
Translation:
HumansAnimalsCells
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Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function. J Exp Med. 2009 Aug 03; 206(8):1739-53.
Trageser D, Iacobucci I, Nahar R, Duy C, von Levetzow G, Klemm L, Park E, Schuh W, Gruber T, Herzog S, Kim YM, Hofmann WK, Li A, Storlazzi CT, Jäck HM, Groffen J, Martinelli G, Heisterkamp N, Jumaa H, Müschen M. PMID: 19620627; PMCID: PMC2722172.
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PubMed Mentions:
67 Fields:
Translation:
HumansAnimalsCells
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Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity. Cell. 2008 Dec 12; 135(6):1130-42.
Tsai AG, Lu H, Raghavan SC, Muschen M, Hsieh CL, Lieber MR. PMID: 19070581; PMCID: PMC2642632.
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PubMed Mentions:
120 Fields:
Translation:
HumansCells
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Identification of different Ikaros cDNA transcripts in Philadelphia-positive adult acute lymphoblastic leukemia by a high-throughput capillary electrophoresis sizing method. Haematologica. 2008 Dec; 93(12):1814-21.
Iacobucci I, Lonetti A, Cilloni D, Messa F, Ferrari A, Zuntini R, Ferrari S, Ottaviani E, Arruga F, Paolini S, Papayannidis C, Piccaluga PP, Soverini S, Saglio G, Pane F, Baruzzi A, Vignetti M, Berton G, Vitale A, Chiaretti S, Müschen M, Foà R, Baccarani M, Martinelli G. PMID: 18838475.
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PubMed Mentions:
12 Fields:
Translation:
Humans
-
Highlight: self-renewal signaling in stem cells. Biol Chem. 2008 Jul; 389(7):787.
Müschen M. PMID: 18681824.
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PubMed Mentions: Fields:
Translation:
Cells
-
The WNT receptor FZD7 contributes to self-renewal signaling of human embryonic stem cells. Biol Chem. 2008 Jul; 389(7):897-903.
Melchior K, Weiss J, Zaehres H, Kim YM, Lutzko C, Roosta N, Hescheler J, Müschen M. PMID: 18681827.
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PubMed Mentions:
35 Fields:
Translation:
HumansCells
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Nilotinib treatment in mouse models of P190 Bcr/Abl lymphoblastic leukemia. Mol Cancer. 2007 Oct 25; 6:67.
Kaur P, Feldhahn N, Zhang B, Trageser D, Müschen M, Pertz V, Groffen J, Heisterkamp N. PMID: 17958915; PMCID: PMC2169263.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells. J Exp Med. 2007 May 14; 204(5):1157-66.
Feldhahn N, Henke N, Melchior K, Duy C, Soh BN, Klein F, von Levetzow G, Giebel B, Li A, Hofmann WK, Jumaa H, Müschen M. PMID: 17485517; PMCID: PMC2118573.
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PubMed Mentions:
42 Fields:
Translation:
HumansCells
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Conventional light chains inhibit the autonomous signaling capacity of the B cell receptor. Immunity. 2007 Mar; 26(3):323-33.
Meixlsperger S, Köhler F, Wossning T, Reppel M, Müschen M, Jumaa H. PMID: 17331747.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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Immunoglobulin class-switch recombination occurs in mantle cell lymphomas. J Pathol. 2006 Jun; 209(2):250-7.
Klapper W, Szczepanowski M, Heidorn K, Müschen M, Liedtke S, Sotnikova A, Andersen NS, Greeve J, Parwaresch R. PMID: 16508921.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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SLP65 deficiency results in perpetual V(D)J recombinase activity in pre-B-lymphoblastic leukemia and B-cell lymphoma cells. Oncogene. 2006 Aug 24; 25(37):5180-6.
Sprangers M, Feldhahn N, Liedtke S, Jumaa H, Siebert R, Müschen M. PMID: 16636677.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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The SRC family kinase LYN redirects B cell receptor signaling in human SLP65-deficient B cell lymphoma cells. Oncogene. 2006 Aug 17; 25(36):5056-62.
Sprangers M, Feldhahn N, Herzog S, Hansmann ML, Reppel M, Hescheler J, Jumaa H, Siebert R, Müschen M. PMID: 16568084.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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BCR-ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cells. Oncogene. 2006 Feb 16; 25(7):1118-24.
Klein F, Feldhahn N, Herzog S, Sprangers M, Mooster JL, Jumaa H, Müschen M. PMID: 16205638.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Deficiency of Bruton's tyrosine kinase in B cell precursor leukemia cells. Proc Natl Acad Sci U S A. 2005 Sep 13; 102(37):13266-71.
Feldhahn N, Río P, Soh BN, Liedtke S, Sprangers M, Klein F, Wernet P, Jumaa H, Hofmann WK, Hanenberg H, Rowley JD, Müschen M. PMID: 16141323; PMCID: PMC1201599.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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B-lymphoid or myeloid lineage identity of cell lines derived from chronic myeloid leukemia blast crisis. Cancer Genet Cytogenet. 2005 Sep; 161(2):187-8.
Soh BN, Klein F, Feldhahn N, Müschen M. PMID: 16102593.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Mimicry of a constitutively active pre-B cell receptor in acute lymphoblastic leukemia cells. J Exp Med. 2005 Jun 06; 201(11):1837-52.
Feldhahn N, Klein F, Mooster JL, Hadweh P, Sprangers M, Wartenberg M, Bekhite MM, Hofmann WK, Herzog S, Jumaa H, Rowley JD, Müschen M. PMID: 15939795; PMCID: PMC2213268.
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PubMed Mentions:
33 Fields:
Translation:
HumansCells
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Tracing the pre-B to immature B cell transition in human leukemia cells reveals a coordinated sequence of primary and secondary IGK gene rearrangement, IGK deletion, and IGL gene rearrangement. J Immunol. 2005 Jan 01; 174(1):367-75.
Klein F, Feldhahn N, Mooster JL, Sprangers M, Hofmann WK, Wernet P, Wartenberg M, Müschen M. PMID: 15611260.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
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The molecular requirements for LAT-mediated differentiation and the role of LAT in limiting pre-B cell expansion. Eur J Immunol. 2004 Dec; 34(12):3614-22.
Su YW, Herzog S, Lotz M, Feldhahn N, Müschen M, Jumaa H. PMID: 15549729.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Interference of BCR-ABL1 kinase activity with antigen receptor signaling in B cell precursor leukemia cells. Cell Cycle. 2004 Jul; 3(7):858-60.
Klein F, Feldhahn N, Müschen M. PMID: 15254401.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. J Exp Med. 2004 Jul 19; 200(2):123-35.
Kögler G, Sensken S, Airey JA, Trapp T, Müschen M, Feldhahn N, Liedtke S, Sorg RV, Fischer J, Rosenbaum C, Greschat S, Knipper A, Bender J, Degistirici O, Gao J, Caplan AI, Colletti EJ, Almeida-Porada G, Müller HW, Zanjani E, Wernet P. PMID: 15263023; PMCID: PMC2212008.
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PubMed Mentions:
259 Fields:
Translation:
HumansAnimalsCells
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The BCR-ABL1 kinase bypasses selection for the expression of a pre-B cell receptor in pre-B acute lymphoblastic leukemia cells. J Exp Med. 2004 Mar 01; 199(5):673-85.
Klein F, Feldhahn N, Harder L, Wang H, Wartenberg M, Hofmann WK, Wernet P, Siebert R, Müschen M. PMID: 14993251; PMCID: PMC2213306.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
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Epstein-Barr virus and the B cell: a secret romance. Trends Microbiol. 2003 Jun; 11(6):243-5.
Schuster VH, Müschen M. PMID: 12823936.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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T lymphoid differentiation in human bone marrow. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6747-52.
Klein F, Feldhahn N, Lee S, Wang H, Ciuffi F, von Elstermann M, Toribio ML, Sauer H, Wartenberg M, Barath VS, Krönke M, Wernet P, Rowley JD, Müschen M. PMID: 12738882; PMCID: PMC164518.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species. FASEB J. 2003 Mar; 17(3):503-5.
Wartenberg M, Ling FC, Müschen M, Klein F, Acker H, Gassmann M, Petrat K, Pütz V, Hescheler J, Sauer H. PMID: 12514119.
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PubMed Mentions:
91 Fields:
Translation:
HumansCells
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Molecular portraits of B cell lineage commitment. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):10014-9.
Müschen M, Lee S, Zhou G, Feldhahn N, Barath VS, Chen J, Moers C, Krönke M, Rowley JD, Wang SM. PMID: 12119411; PMCID: PMC126616.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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The origin of CD95-gene mutations in B-cell lymphoma. Trends Immunol. 2002 Feb; 23(2):75-80.
Müschen M, Rajewsky K, Krönke M, Küppers R. PMID: 11929130.
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PubMed Mentions:
16 Fields:
Translation:
Humans
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Resistance to CD95-mediated apoptosis in breast cancer is not due to somatic mutation of the CD95 gene. Int J Cancer. 2001 Apr 15; 92(2):309-10.
Müschen M, Re D, Betz B, Moers C, Wolf J, Niederacher D, Diehl V, Beckmann MW. PMID: 11291062.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Molecular single-cell analysis of Hodgkin- and Reed-Sternberg cells harboring unmutated immunoglobulin variable region genes. Lab Invest. 2001 Mar; 81(3):289-95.
Müschen M, Küppers R, Spieker T, Bräuninger A, Rajewsky K, Hansmann ML. PMID: 11310822.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Oct-2 and Bob-1 deficiency in Hodgkin and Reed Sternberg cells. Cancer Res. 2001 Mar 01; 61(5):2080-4.
Re D, Müschen M, Ahmadi T, Wickenhauser C, Staratschek-Jox A, Holtick U, Diehl V, Wolf J. PMID: 11280769.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Evidence that Hodgkin and Reed-Sternberg cells in Hodgkin disease do not represent cell fusions. Blood. 2001 Feb 01; 97(3):818-21.
Küppers R, Bräuninger A, Müschen M, Distler V, Hansmann ML, Rajewsky K. PMID: 11157505.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction. J Exp Med. 2000 Dec 18; 192(12):1833-40.
Müschen M, Re D, Jungnickel B, Diehl V, Rajewsky K, Küppers R. PMID: 11120779; PMCID: PMC2213498.
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PubMed Mentions:
46 Fields:
Translation:
HumansCells
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Somatic mutations of the CD95 gene in Hodgkin and Reed-Sternberg cells. Cancer Res. 2000 Oct 15; 60(20):5640-3.
Müschen M, Re D, Bräuninger A, Wolf J, Hansmann ML, Diehl V, Küppers R, Rajewsky K. PMID: 11059754.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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CD95 ligand expression as a criterion of malignant transformation in breast cancer. J Pathol. 2000 Aug; 191(4):468-70.
Müschen M, Beckmann MW. PMID: 10918226.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Rare occurrence of classical Hodgkin's disease as a T cell lymphoma. J Exp Med. 2000 Jan 17; 191(2):387-94.
Müschen M, Rajewsky K, Bräuninger A, Baur AS, Oudejans JJ, Roers A, Hansmann ML, Küppers R. PMID: 10637283; PMCID: PMC2195757.
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PubMed Mentions:
47 Fields:
Translation:
HumansCells
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Defining CD95 as a tumor suppressor gene. J Mol Med (Berl). 2000; 78(6):312-25.
Müschen M, Warskulat U, Beckmann MW. PMID: 11001528.
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PubMed Mentions:
42 Fields:
Translation:
Humans
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CD95 ligand expression as a mechanism of immune escape in breast cancer. Immunology. 2000 Jan; 99(1):69-77.
Müschen M, Moers C, Warskulat U, Even J, Niederacher D, Beckmann MW. PMID: 10651943; PMCID: PMC2327134.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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CD95 ligand expression in dedifferentiated breast cancer. J Pathol. 1999 Nov; 189(3):378-86.
Müschen M, Moers C, Warskulat U, Niederacher D, Betz B, Even J, Lim A, Josien R, Beckmann MW, Häussinger D. PMID: 10547600.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Involvement of soluble CD95 in Churg-Strauss syndrome. Am J Pathol. 1999 Sep; 155(3):915-25.
Müschen M, Warskulat U, Perniok A, Even J, Moers C, Kismet B, Temizkan N, Simon D, Schneider M, Häussinger D. PMID: 10487849; PMCID: PMC1866905.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Involvement of CD95 (Apo-1/Fas) ligand expressed by rat Kupffer cells in hepatic immunoregulation. Gastroenterology. 1999 Mar; 116(3):666-77.
Müschen M, Warskulat U, Peters-Regehr T, Bode JG, Kubitz R, Häussinger D. PMID: 10029626.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Regulation of CD95 (Apo-1/Fas) ligand and receptor expression in squamous-cell carcinoma by interferon-gamma and cisplatin. Int J Cancer. 1999 Feb 09; 80(4):564-72.
Moers C, Warskulat U, Müschen M, Even J, Niederacher D, Josien R, Koldovsky U, Beckmann MW, Häussinger D. PMID: 9935158.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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A critical role for transforming growth factor-beta in donor transfusion-induced allograft tolerance. J Clin Invest. 1998 Dec 01; 102(11):1920-6.
Josien R, Douillard P, Guillot C, Müschen M, Anegon I, Chetritt J, Menoret S, Vignes C, Soulillou JP, Cuturi MC. PMID: 9835616; PMCID: PMC509143.
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HumansAnimalsCells
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Deranged CD95 system in a case of Churg-Strauss vasculitis. Gastroenterology. 1998 Jun; 114(6):1351-2.
Müschen M, Warskulat U, Häussinger D, Moers C, Simon D, Even J. PMID: 9618660.
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HumansCells
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Regulation of CD95 (APO-1/Fas) receptor and ligand expression by lipopolysaccharide and dexamethasone in parenchymal and nonparenchymal rat liver cells. Hepatology. 1998 Jan; 27(1):200-8.
Müschen M, Warskulat U, Douillard P, Gilbert E, Häussinger D. PMID: 9425938.
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18 Fields:
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AnimalsCells