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Clifford Lowell, MD, PhD

Title(s)Professor, Laboratory Medicine
SchoolSchool of Medicine
Address533 Parnassus Avenue
San Francisco CA 94117
Phone415-476-2963
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    Other Positions
    Title(s)Chair, Laboratory Medicine


    Collapse Biography 
    Collapse Education and Training
    Stanford UniversityBS1979Biology
    Johns Hopkins UniversityMD - PhD1986School of Medicine
    Johns Hopkins HospitalOsler Medical House Officier1989Medicine
    University of California, San FranciscoClinical Fellowship 1992Oncology
    University of California, San FranciscoPost-Doctoral Research Fellowship1995Laboratory: Harold Varmus
    Collapse Awards and Honors
    LLS2001Leukemia/Lymphoma Society Scholar
    FASEB2009Elected FASEB conference organizer
    Universite du Quebec2014Elected Advisory Board Neutrophil Immunity
    UCSF2015Distinguished Professorship

    Collapse Overview 
    Collapse Overview
    The Lowell laboratory studies tyrosine kinase based signal transduction in innate immune cells. Our general approach involves examination of innate immune function in knockout mice lacking various members of the Src-family or Syk family of tyrosine kinases. Many of these studies also involve use of mice lacking these kinases in specific hematopoietic lineages, such as neutrophils, macrophages or DCs, generated through Cre/Lox technology. We have also used this approach to study other tyrosine kinases (Pyk2/Fak) and intracellular signaling molecules (WASp, STIM1) in innate immune cells. Our major findings have illuminated the function of Src-family and Syk kinases in leukocyte integrin signaling – loss of these kinases results in significant defects in inflammatory and host defense functions mediated by integrins. We have found that leukocyte integrin signaling utilizes the same intracellular pathways initiated by classical immunoreceptors (such as Fc?Rs) by co-opting ITAM-containing adapter proteins. We have also demonstrated the important ways these kinases regulate innate immune cells in the setting of autoimmune and inflammatory diseases, using the Lyn kinase-deficient model. Ongoing studies also involve examination of tyrosine phosphatases (mainly SHP-1) in the counter regulation tyrosine kinases, especially in the setting of hematopoietic malignancy, as well as studies of calcium signaling proteins, using mice lacking these genes specifically in myeloid lineage cells. Publications total = 191

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of Innate Immune Signaling by Lyn Kinase
    NIH/NIAID R01AI113272Feb 1, 2015 - Jan 31, 2020
    Role: Principal Investigator
    Signal Transduction in the Immune System-FASEB Summer Conference
    NIH/NIAID R13AI084313Jun 21, 2009 - Jun 29, 2009
    Role: Principal Investigator
    Innate immune regulation of inflammation and adaptive immunity
    NIH/NIAID P01AI078869Jul 15, 2008 - Jun 30, 2013
    Role: Co-Investigator
    FASEB Summer Conference on Signal Transduction in the Immune System
    NIH/NIAID R13AI074219Jun 1, 2007 - May 31, 2008
    Role: Principal Investigator
    Transfusion and Lung Injury
    NIH/NHLBI P50HL081027Sep 30, 2005 - Aug 31, 2011
    Role: Co-Investigator
    Mechanisms of Neutrophil Activation
    NIH/NIAID R01AI065495Jul 1, 2005 - Mar 31, 2011
    Role: Principal Investigator
    Proximal Signaling Events in Leukocyte Integrin Function
    NIH/FIC R03TW006831Aug 15, 2004 - Jul 31, 2008
    Role: Principal Investigator
    Signaling by Cytoplasmic Tyrosine Kinases in Leukocytes
    NIH/NIDDK R01DK058066Jul 1, 2001 - Jun 30, 2006
    Role: Principal Investigator
    Signaling by Cytoplasmic Tyrosine Kinases in Leukocytes
    NIH/NIAID R01AI068150Aug 1, 2000 - Jan 31, 2017
    Role: Principal Investigator
    MURINE MODELS TO INVESTIGATE THE HEMATOLOGIC SYSTEM
    NIH/NIDDK P01DK050267Aug 1, 1997 - Jul 31, 2001
    Role: Co-Investigator
    TRANSFUSION BIOLOGY AND MEDICINE
    NIH/NHLBI P50HL054476Feb 1, 1996 - Dec 31, 2006
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defense. Proc Natl Acad Sci U S A. 2020 Sep 14. Grimes D, Johnson R, Pashos M, Cummings C, Kang C, Sampedro GR, Tycksen E, McBride HJ, Sah R, Lowell CA, Clemens RA. PMID: 32929002.
      View in: PubMed   Mentions:    Fields:    
    2. The Ubiquitin-Modifying Enzyme A20 Terminates C-Type Lectin Receptor Signals and Is a Suppressor of Host Defense against Systemic Fungal Infection. Infect Immun. 2020 Aug 19; 88(9). Liang J, Zhang JJ, Huang HI, Kanayama M, Youssef N, Jin YJ, Reyes EY, Abram CL, Yang S, Lowell CA, Wang D, Shao L, Shinohara ML, Zhang JY, Hammer GE. PMID: 32540868.
      View in: PubMed   Mentions:    Fields:    
    3. Complement activation on endothelium initiates antibody-mediated acute lung injury. J Clin Invest. 2020 Jul 30. Cleary SJ, Kwaan N, Tian JJ, Calabrese DR, Mallavia B, Magnen M, Greenland JR, Urisman A, Singer JP, Hays SR, Kukreja J, Hay AM, Howie HL, Toy P, Lowell CA, Morrell CN, Zimring JC, Looney MR. PMID: 32730229.
      View in: PubMed   Mentions:    Fields:    
    4. Inhibition of the SRC Kinase HCK Impairs STAT3-Dependent Gastric Tumor Growth in Mice. Cancer Immunol Res. 2020 04; 8(4):428-435. Poh AR, Dwyer AR, Eissmann MF, Chand AL, Baloyan D, Boon L, Murrey MW, Whitehead L, O'Brien M, Lowell CA, Putoczki TL, Pixley FJ, O'Donoghue RJJ, Ernst M. PMID: 31992566.
      View in: PubMed   Mentions: 1     Fields:    
    5. Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils. J Clin Invest. 2020 01 02; 130(1):389-403. Mahiddine K, Blaisdell A, Ma S, Créquer-Grandhomme A, Lowell CA, Erlebacher A. PMID: 31600172.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    6. Src family kinase-mediated vesicle trafficking is critical for neutrophil basement membrane penetration. Haematologica. 2020 Jul; 105(7):1845-1856. Rohwedder I, Kurz ARM, Pruenster M, Immler R, Pick R, Eggersmann T, Klapproth S, Johnson JL, Alsina SM, Lowell CA, Mócsai A, Catz SD, Sperandio M. PMID: 31699792.
      View in: PubMed   Mentions:    Fields:    
    7. L-selectin shedding affects bacterial clearance in the lung: a new regulatory pathway for integrin outside-in signaling. Blood. 2019 10 24; 134(17):1445-1457. Cappenberg A, Margraf A, Thomas K, Bardel B, McCreedy DA, Van Marck V, Mellmann A, Lowell CA, Zarbock A. PMID: 31366620.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    8. CARD9 mediates dendritic cell-induced development of Lyn deficiency-associated autoimmune and inflammatory diseases. Sci Signal. 2019 10 08; 12(602). Ma J, Abram CL, Hu Y, Lowell CA. PMID: 31594855.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    9. CRAC channel regulation of innate immune cells in health and disease. Cell Calcium. 2019 03; 78:56-65. Clemens RA, Lowell CA. PMID: 30641250.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    10. Early Targeting of L-Selectin on Leukocytes Promotes Recovery after Spinal Cord Injury, Implicating Novel Mechanisms of Pathogenesis. eNeuro. 2018 Jul-Aug; 5(4). McCreedy DA, Lee S, Sontag CJ, Weinstein P, Olivas AD, Martinez AF, Fandel TM, Trivedi A, Lowell CA, Rosen SD, Noble-Haeusslein LJ. PMID: 30225356.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    11. Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma. Blood Adv. 2018 07 10; 2(13):1595-1607. Rubenstein JL, Geng H, Fraser EJ, Formaker P, Chen L, Sharma J, Killea P, Choi K, Ventura J, Kurhanewicz J, Lowell C, Hwang J, Treseler P, Sneed PK, Li J, Wang X, Chen N, Gangoiti J, Munster PN, Damato B. PMID: 29986852.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    12. PRN473, an inhibitor of Bruton's tyrosine kinase, inhibits neutrophil recruitment via inhibition of macrophage antigen-1 signalling. Br J Pharmacol. 2018 02; 175(3):429-439. Herter JM, Margraf A, Volmering S, Correia BE, Bradshaw JM, Bisconte A, Hill RJ, Langrish CL, Lowell CA, Zarbock A. PMID: 29130484.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    13. Neutrophils: Their Role in Innate and Adaptive Immunity 2017. J Immunol Res. 2017; 2017:9748345. Rosales C, Lowell CA, Schnoor M, Uribe-Querol E. PMID: 29238732.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    14. B cell autoimmunity at the extremes. Nat Immunol. 2017 09 19; 18(10):1065-1066. Zikherman J, Lowell CA. PMID: 28926534.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    15. Efficiency and Specificity of Gene Deletion in Lung Epithelial Doxycycline-Inducible Cre Mice. Am J Respir Cell Mol Biol. 2017 08; 57(2):248-257. Sinha M, Lowell CA. PMID: 28287822.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    16. STIM1 and STIM2 cooperatively regulate mouse neutrophil store-operated calcium entry and cytokine production. Blood. 2017 09 28; 130(13):1565-1577. Clemens RA, Chong J, Grimes D, Hu Y, Lowell CA. PMID: 28724541.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    17. Role of MyD88 signaling in the imiquimod-induced mouse model of psoriasis: focus on innate myeloid cells. J Leukoc Biol. 2017 09; 102(3):791-803. Costa S, Marini O, Bevilacqua D, DeFranco AL, Hou B, Lonardi S, Vermi W, Rodegher P, Panato A, Tagliaro F, Lowell CA, Cassatella MA, Girolomoni G, Scapini P. PMID: 28642279.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    18. Shp1 function in myeloid cells. J Leukoc Biol. 2017 09; 102(3):657-675. Abram CL, Lowell CA. PMID: 28606940.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    19. Differentiating pulmonary transfusion reactions using recipient and transfusion factors. Transfusion. 2017 07; 57(7):1684-1690. Roubinian NH, Looney MR, Keating S, Kor DJ, Lowell CA, Gajic O, Hubmayr R, Gropper M, Koenigsberg M, Wilson GA, A Matthay M, Toy P, Murphy EL. PMID: 28470756.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    20. SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin. Nature. 2017 04 27; 544(7651):493-497. Chen J, Zhong MC, Guo H, Davidson D, Mishel S, Lu Y, Rhee I, Pérez-Quintero LA, Zhang S, Cruz-Munoz ME, Wu N, Vinh DC, Sinha M, Calderon V, Lowell CA, Danska JS, Veillette A. PMID: 28424516.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    21. Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression. Cancer Cell. 2017 04 10; 31(4):563-575.e5. Poh AR, Love CG, Masson F, Preaudet A, Tsui C, Whitehead L, Monard S, Khakham Y, Burstroem L, Lessene G, Sieber O, Lowell C, Putoczki TL, O'Donoghue RJJ, Ernst M. PMID: 28399411.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    22. Skap2 is required for ß2 integrin-mediated neutrophil recruitment and functions. J Exp Med. 2017 03 06; 214(3):851-874. Boras M, Volmering S, Bokemeyer A, Rossaint J, Block H, Bardel B, Van Marck V, Heitplatz B, Kliche S, Reinhold A, Lowell C, Zarbock A. PMID: 28183734.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    23. Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9. PLoS One. 2016; 11(12):e0167693. Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM, DeFranco AL. PMID: 27977701.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    24. Targeting NF-KB Activation in Novel Intracranial Models of CNS Lymphoma. Blood. 2016 Dec 2; 128(22):777-777. Huimin Geng, Huaxin Gao, Cigall Kadoch, Ming Lu, Lingjing Chen, Rana Anjum, Lisa Drew, Sebastien Degorce, Keith Dillman, Michele Mayo, Shawn Anderson, Colin Collins, Clifford A. Lowell, James L. Rubenstein. .
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    25. Isolation of Highly Pure Primary Mouse Alveolar Epithelial Type II Cells by Flow Cytometric Cell Sorting. Bio Protoc. 2016 Nov 20; 6(22). Sinha M, Lowell CA. PMID: 28180137.
      View in: PubMed   Mentions:
    26. Leishmania Uses Mincle to Target an Inhibitory ITAM Signaling Pathway in Dendritic Cells that Dampens Adaptive Immunity to Infection. Immunity. 2016 10 18; 45(4):788-801. Iborra S, Martínez-López M, Cueto FJ, Conde-Garrosa R, Del Fresno C, Izquierdo HM, Abram CL, Mori D, Campos-Martín Y, Reguera RM, Kemp B, Yamasaki S, Robinson MJ, Soto M, Lowell CA, Sancho D. PMID: 27742545.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    27. LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity. J Clin Invest. 2016 10 03; 126(10):3758-3771. Proekt I, Miller CN, Jeanne M, Fasano KJ, Moon JJ, Lowell CA, Gould DB, Anderson MS, DeFranco AL. PMID: 27571405.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    28. Downregulation of the Syk Signaling Pathway in Intestinal Dendritic Cells Is Sufficient To Induce Dendritic Cells That Inhibit Colitis. J Immunol. 2016 10 01; 197(7):2948-57. Hang L, Blum AM, Kumar S, Urban JF, Mitreva M, Geary TG, Jardim A, Stevenson MM, Lowell CA, Weinstock JV. PMID: 27559049.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    29. MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase. PLoS Pathog. 2016 08; 12(8):e1005787. Wang H, Li M, Hung CY, Sinha M, Lee LM, Wiesner DL, LeBert V, Lerksuthirat T, Galles K, Suresh M, DeFranco AL, Lowell CA, Klein BS, Wüthrich M. PMID: 27542117.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    30. Immune Defense Protein Expression in Highly Purified Mouse Lung Epithelial Cells. Am J Respir Cell Mol Biol. 2016 06; 54(6):802-13. Sinha M, Lowell CA. PMID: 26574781.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    31. FleA Expression in Aspergillus fumigatus Is Recognized by Fucosylated Structures on Mucins and Macrophages to Prevent Lung Infection. PLoS Pathog. 2016 Apr; 12(4):e1005555. Kerr SC, Fischer GJ, Sinha M, McCabe O, Palmer JM, Choera T, Lim FY, Wimmerova M, Carrington SD, Yuan S, Lowell CA, Oscarson S, Keller NP, Fahy JV. PMID: 27058347.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    32. Neutrophils in animal models of autoimmune disease. Semin Immunol. 2016 04; 28(2):174-86. Németh T, Mócsai A, Lowell CA. PMID: 27067180.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    33. Corrigendum: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2016 06 02; 534(7605):138. Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M. PMID: 26958840.
      View in: PubMed   Mentions:    Fields:    
    34. Neutrophils: Their Role in Innate and Adaptive Immunity. J Immunol Res. 2016; 2016:1469780. Rosales C, Demaurex N, Lowell CA, Uribe-Querol E. PMID: 27006954.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    35. The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation. Immunity. 2016 Jan 19; 44(1):73-87. Volmering S, Block H, Boras M, Lowell CA, Zarbock A. PMID: 26777396.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    36. Integrins: Regulation of Adhesion and Downstream Signaling. Encyclopedia of Immunobiology. 2016 Jan 1; 72-82. Clifford A. Lowell. .
      View in: Publisher Site   Mentions:
    37. Targeted Activation of B Cell Autoimmunity Checkpoints in Acute Lymphoblastic Leukemia. Blood. 2015 Dec 3; 126(23):3716-3716. Zhengshan Chen, Huimin Geng, Clifford A. Lowell, Arthur Weiss, Stephen P. Hunger, Ari Melnick, Markus Muschen. .
      View in: Publisher Site   Mentions:
    38. LynA regulates an inflammation-sensitive signaling checkpoint in macrophages. Elife. 2015 Oct 30; 4. Freedman TS, Tan YX, Skrzypczynska KM, Manz BN, Sjaastad FV, Goodridge HS, Lowell CA, Weiss A. PMID: 26517880.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    39. Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses. Immunity. 2015 Oct 20; 43(4):764-75. Yi T, Li J, Chen H, Wu J, An J, Xu Y, Hu Y, Lowell CA, Cyster JG. PMID: 26453377.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    40. Lung Ischemia-Reperfusion is a Sterile Inflammatory Process Influenced by Commensal Microbiota in Mice. Shock. 2015 Sep; 44(3):272-9. Prakash A, Sundar SV, Zhu YG, Tran A, Lee JW, Lowell C, Hellman J. PMID: 26196836.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    41. The Src-Family Kinases Hck and Fgr Regulate Early Lipopolysaccharide-Induced Myeloid Cell Recruitment into the Lung and Their Ability To Secrete Chemokines. J Immunol. 2015 Sep 01; 195(5):2383-95. Mazzi P, Caveggion E, Lapinet-Vera JA, Lowell CA, Berton G. PMID: 26232427.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    42. Cross-Talk between Shp1 and PIPKI? Controls Leukocyte Recruitment. J Immunol. 2015 Aug 01; 195(3):1152-61. Stadtmann A, Block H, Volmering S, Abram C, Sohlbach C, Boras M, Lowell CA, Zarbock A. PMID: 26101325.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    43. Intracellular signalling during neutrophil recruitment. Cardiovasc Res. 2015 Aug 01; 107(3):373-85. Mócsai A, Walzog B, Lowell CA. PMID: 25998986.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    44. Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2015 May 21; 521(7552):357-61. Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M. PMID: 25799995.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    45. A2.21 The role of HCK, FGR and LYN in in vivo inflammation in mice. Annals of the Rheumatic Diseases. 2015 Mar 1; 74(Suppl 1):a24-a24. M Kovács, T Németh, Z Jakus, C Sitaru, E Simon, K Futosi, B Botz, Z Helyes, CA Lowell, A Mócsai. .
      View in: Publisher Site   Mentions:
    46. Store-operated calcium signaling in neutrophils. J Leukoc Biol. 2015 Oct; 98(4):497-502. Clemens RA, Lowell CA. PMID: 25714804.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    47. Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions. Transfusion. 2015 Aug; 55(8):1838-46. Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL. PMID: 25702590.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    48. Recipient clinical risk factors predominate in possible transfusion-related acute lung injury. Transfusion. 2015 May; 55(5):947-52. Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, Sanchez Rosen R, Looney MR. PMID: 25488517.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    49. Harnessing Negative B Cell Selection to Overcome Drug-Resistance in Acute Lymphoblastic Leukemia. Blood. 2014 Dec 6; 124(21):792-792. Zhengshan Chen, Seyedmehdi Shojaee, Huimin Geng, Jae-Woong Lee, Maike Buchner, Lars Klemm, Clifford A. Lowell, Elisabeth Paietta, Cheryl L. Willman, William L. Carroll, Ari Melnick, Jae U. Jung, Hassan Jumaa, John E. Coligan, Silvia Bolland, Tak W. Mak, Markus Muschen. .
      View in: Publisher Site   Mentions:
    50. The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment. J Exp Med. 2014 Sep 22; 211(10):1993-2011. Kovács M, Németh T, Jakus Z, Sitaru C, Simon E, Futosi K, Botz B, Helyes Z, Lowell CA, Mócsai A. PMID: 25225462.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    51. Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*. Crit Care Med. 2014 Jul; 42(7):1676-87. Looney MR, Roubinian N, Gajic O, Gropper MA, Hubmayr RD, Lowell CA, Bacchetti P, Wilson G, Koenigsberg M, Lee DC, Wu P, Grimes B, Norris PJ, Murphy EL, Gandhi MJ, Winters JL, Mair DC, Schuller RM, Hirschler NV, Rosen RS, Matthay MA, Toy P. PMID: 24776608.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    52. Actin cytoskeleton reorganization by Syk regulates Fc? receptor responsiveness by increasing its lateral mobility and clustering. Dev Cell. 2014 Jun 09; 29(5):534-546. Jaumouillé V, Farkash Y, Jaqaman K, Das R, Lowell CA, Grinstein S. PMID: 24914558.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    53. ROS-triggered phosphorylation of complex II by Fgr kinase regulates cellular adaptation to fuel use. Cell Metab. 2014 Jun 03; 19(6):1020-33. Acín-Pérez R, Carrascoso I, Baixauli F, Roche-Molina M, Latorre-Pellicer A, Fernández-Silva P, Mittelbrunn M, Sanchez-Madrid F, Pérez-Martos A, Lowell CA, Manfredi G, Enríquez JA. PMID: 24856931.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    54. Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice. J Immunol Methods. 2014 Jun; 408:89-100. Abram CL, Roberge GL, Hu Y, Lowell CA. PMID: 24857755.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    55. Molecular editing of cellular responses by the high-affinity receptor for IgE. Science. 2014 Feb 28; 343(6174):1021-5. Suzuki R, Leach S, Liu W, Ralston E, Scheffel J, Zhang W, Lowell CA, Rivera J. PMID: 24505132.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    56. STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense. Blood. 2014 Apr 03; 123(14):2238-49. Zhang H, Clemens RA, Liu F, Hu Y, Baba Y, Theodore P, Kurosaki T, Lowell CA. PMID: 24493668.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    57. Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice. J Immunol. 2014 Feb 01; 192(3):875-85. Hua Z, Gross AJ, Lamagna C, Ramos-Hernández N, Scapini P, Ji M, Shao H, Lowell CA, Hou B, DeFranco AL. PMID: 24379120.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    58. B cell-specific loss of Lyn kinase leads to autoimmunity. J Immunol. 2014 Feb 01; 192(3):919-28. Lamagna C, Hu Y, DeFranco AL, Lowell CA. PMID: 24376269.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    59. Inhibitory Receptors and Phosphatases Enable Oncogenic Tyrosine Kinase Signaling In B Cell Lineage Leukemia. Blood. 2013 Nov 15; 122(21):229-229. Zhengshan Chen, Seyedmehdi Shojaee, Huimin Geng, Jaewoong Lee, Maike Buchner, Lars Klemm, Clifford A. Lowell, Elisabeth Paietta, Cheryl L. Willman, William L. Carroll, Ari M. Melnick, Jae U. Jung, Hassan Jumaa, John E. Coligan, Silvia Bolland, Tak W. Mak, Markus Muschen. .
      View in: Publisher Site   Mentions:
    60. Novel Intracranial Xenografts Of CNS Lymphoma Implicate a Role For Cereblon As a Mediator Of Lenalidomide Efficacy. Blood. 2013 Nov 15; 122(21):374-374. Hua-Xin Gao, Shawn Anderson, Cigall Kadoch, Mekhala Maiti, Lingjing Chen, Dong-Han Yao, Gerd Melkus, Maria Wang, Yan Ren, Michael Breider, Carla Heise, Clifford A. Lowell, Colin Collins, James L. Rubenstein. .
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    61. Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma. Clin Cancer Res. 2014 Feb 15; 20(4):1029-41. Kadoch C, Li J, Wong VS, Chen L, Cha S, Munster P, Lowell CA, Shuman MA, Rubenstein JL. PMID: 24190981.
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    62. A critical role for Lyn kinase in strengthening endothelial integrity and barrier function. Blood. 2013 Dec 12; 122(25):4140-9. Han J, Zhang G, Welch EJ, Liang Y, Fu J, Vogel SM, Lowell CA, Du X, Cheresh DA, Malik AB, Li Z. PMID: 24108461.
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    63. Expression of the TEL-Syk fusion protein in hematopoietic stem cells leads to rapidly fatal myelofibrosis in mice. PLoS One. 2013; 8(10):e77542. Graham MT, Abram CL, Hu Y, Lowell CA. PMID: 24116232.
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    64. The multifaceted functions of neutrophils. Annu Rev Pathol. 2014; 9:181-218. Mayadas TN, Cullere X, Lowell CA. PMID: 24050624.
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    65. Neutrophils mediate antibody-induced antitumor effects in mice. Blood. 2013 Oct 31; 122(18):3160-4. Albanesi M, Mancardi DA, Jönsson F, Iannascoli B, Fiette L, Di Santo JP, Lowell CA, Bruhns P. PMID: 23980063.
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    66. Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):E3311-20. Lamagna C, Scapini P, van Ziffle JA, DeFranco AL, Lowell CA. PMID: 23940344.
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    67. Hck contributes to bone homeostasis by controlling the recruitment of osteoclast precursors. FASEB J. 2013 Sep; 27(9):3608-18. Vérollet C, Gallois A, Dacquin R, Lastrucci C, Pandruvada SN, Ortega N, Poincloux R, Behar A, Cougoule C, Lowell C, Al Saati T, Jurdic P, Maridonneau-Parini I. PMID: 23742809.
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    68. CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma. Blood. 2013 Jun 06; 121(23):4740-8. Rubenstein JL, Wong VS, Kadoch C, Gao HX, Barajas R, Chen L, Josephson SA, Scott B, Douglas V, Maiti M, Kaplan LD, Treseler PA, Cha S, Hwang JH, Cinque P, Cyster JG, Lowell C. PMID: 23570798.
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    69. Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice. Immunity. 2013 Mar 21; 38(3):489-501. Abram CL, Roberge GL, Pao LI, Neel BG, Lowell CA. PMID: 23521885.
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    70. Class I phosphoinositide-3-kinases and SRC kinases play a nonredundant role in regulation of adhesion-independent and -dependent neutrophil reactive oxygen species generation. J Immunol. 2013 Apr 01; 190(7):3648-60. Fumagalli L, Campa CC, Germena G, Lowell CA, Hirsch E, Berton G. PMID: 23447687.
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    71. Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization. Dev Cell. 2013 Feb 25; 24(4):372-83. Heit B, Kim H, Cosío G, Castaño D, Collins R, Lowell CA, Kain KC, Trimble WS, Grinstein S. PMID: 23395392.
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    72. Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung. Cell Rep. 2012 Dec 27; 2(6):1762-73. Jhingran A, Mar KB, Kumasaka DK, Knoblaugh SE, Ngo LY, Segal BH, Iwakura Y, Lowell CA, Hamerman JA, Lin X, Hohl TM. PMID: 23200858.
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    73. Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma. Blood. 2013 Jan 31; 121(5):745-51. Rubenstein JL, Li J, Chen L, Advani R, Drappatz J, Gerstner E, Batchelor T, Krouwer H, Hwang J, Auerback G, Kadoch C, Lowell C, Munster P, Cha S, Shuman MA, Damon LE. PMID: 23197589.
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    74. Macrophages require Skap2 and Sirpa for integrin-stimulated cytoskeletal rearrangement. J Cell Sci. 2012 Nov 15; 125(Pt 22):5535-45. Alenghat FJ, Baca QJ, Rubin NT, Pao LI, Matozaki T, Lowell CA, Golan DE, Neel BG, Swanson KD. PMID: 22976304.
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    75. Dectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived antigens. J Biol Chem. 2012 Oct 05; 287(41):34149-56. Ma J, Becker C, Lowell CA, Underhill DM. PMID: 22902620.
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    76. Distinct and overlapping functional roles of Src family kinases in mouse platelets. J Thromb Haemost. 2012 Aug; 10(8):1631-45. Séverin S, Nash CA, Mori J, Zhao Y, Abram C, Lowell CA, Senis YA, Watson SP. PMID: 22694307.
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    77. Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury. J Exp Med. 2012 Feb 13; 209(2):407-21. Block H, Herter JM, Rossaint J, Stadtmann A, Kliche S, Lowell CA, Zarbock A. PMID: 22291096.
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    78. Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans. Anesth Analg. 2012 Mar; 114(3):511-9. Weiskopf RB, Feiner J, Toy P, Twiford J, Shimabukuro D, Lieberman J, Looney MR, Lowell CA, Gropper MA. PMID: 22262647.
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    79. Establishment of a Novel System for Studying the Syk Function in B Cells. Chembiomolecular Science. 2012 Jan 1; 177-182. Tomohiro Kurosaki, Clifford A. Lowell. .
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    80. Overview: studying integrins in vivo. Methods Mol Biol. 2012; 757:369-97. Lowell CA, Mayadas TN. PMID: 21909923.
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    81. B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K. Proc Natl Acad Sci U S A. 2012 Jan 03; 109(1):267-72. Ni M, MacFarlane AW, Toft M, Lowell CA, Campbell KS, Hamerman JA. PMID: 22187458.
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    82. Transfusion-related acute lung injury: incidence and risk factors. Blood. 2012 Feb 16; 119(7):1757-67. Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, Hirschler N, Sanchez Rosen R, Matthay MA. PMID: 22117051.
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    83. Genomic and Molecular Properties of Relapsed CNS Lymphoma Using Novel Primary Meningeal Lymphoma Cell Lines and Intracranial Xenografts,. Blood. 2011 Nov 18; 118(21):3477-3477. Hua-Xin Gao, Shawn Anderson, Lingjing Chen, Cigall Kadoch, Byron C Hann, Clifford Lowell, Colin Collins, James L. Rubenstein. .
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    84. Dynamic Changes in Macrophage Polarization Correlate with Progression and Response in CNS Lymphoma: Insights Into the Transcriptome of Lymphoma-Associated M2 Macrophages,. Blood. 2011 Nov 18; 118(21):3219-3219. Cigall Kadoch, Valerie Wong, Lingjing Chen, Anna Bet-Lachin, Ritu Roy, William Hyun, Caroline Behler, Clifford Lowell, James L. Rubenstein. .
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    85. Strain-dependent induction of neutrophil histamine production and cell death by Pseudomonas aeruginosa. J Leukoc Biol. 2012 Feb; 91(2):275-84. Xu X, Zhang H, Song Y, Lynch SV, Lowell CA, Wiener-Kronish JP, Caughey GH. PMID: 22075928.
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    86. Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureus. Immunity. 2011 Nov 23; 35(5):757-69. Zhu JW, Doan K, Park J, Chau AH, Zhang H, Lowell CA, Weiss A. PMID: 22078799.
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    87. Deletion of Syk in neutrophils prevents immune complex arthritis. J Immunol. 2011 Oct 15; 187(8):4319-30. Elliott ER, Van Ziffle JA, Scapini P, Sullivan BM, Locksley RM, Lowell CA. PMID: 21918195.
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    88. B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):E823-32. Scapini P, Lamagna C, Hu Y, Lee K, Tang Q, DeFranco AL, Lowell CA. PMID: 21911371.
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    89. The process of macrophage migration promotes matrix metalloproteinase-independent invasion by tumor cells. J Immunol. 2011 Oct 01; 187(7):3806-14. Guiet R, Van Goethem E, Cougoule C, Balor S, Valette A, Al Saati T, Lowell CA, Le Cabec V, Maridonneau-Parini I. PMID: 21880978.
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    90. Critical role for Syk in responses to vascular injury. Blood. 2011 Nov 03; 118(18):5000-10. Andre P, Morooka T, Sim D, Abe K, Lowell C, Nanda N, Delaney S, Siu G, Yan Y, Hollenbach S, Pandey A, Gao H, Wang Y, Nakajima K, Parikh SA, Shi C, Phillips D, Owen W, Sinha U, Simon DI. PMID: 21881044.
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    91. Differential transformation capacity of Src family kinases during the initiation of prostate cancer. Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16):6579-84. Cai H, Smith DA, Memarzadeh S, Lowell CA, Cooper JA, Witte ON. PMID: 21464326.
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    92. Neutrophils give us a shock. J Clin Invest. 2011 Apr; 121(4):1260-3. Lowell CA. PMID: 21436575.
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    93. Paired immunoglobin-like receptor-B regulates the suppressive function and fate of myeloid-derived suppressor cells. Immunity. 2011 Mar 25; 34(3):385-95. Ma G, Pan PY, Eisenstein S, Divino CM, Lowell CA, Takai T, Chen SH. PMID: 21376641.
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    94. Src-family and Syk kinases in activating and inhibitory pathways in innate immune cells: signaling cross talk. Cold Spring Harb Perspect Biol. 2011 Mar 01; 3(3). Lowell CA. PMID: 21068150.
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    95. IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina. J Immunol. 2011 Feb 15; 186(4):2372-81. Nelson MP, Christmann BS, Werner JL, Metz AE, Trevor JL, Lowell CA, Steele C. PMID: 21220696.
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    96. Pyk2 is required for neutrophil degranulation and host defense responses to bacterial infection. J Immunol. 2011 Feb 01; 186(3):1656-65. Kamen LA, Schlessinger J, Lowell CA. PMID: 21187437.
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    97. Interferon-? production by neutrophils during bacterial pneumonia in mice. Am J Respir Crit Care Med. 2011 May 15; 183(10):1391-401. Yamada M, Gomez JC, Chugh PE, Lowell CA, Dinauer MC, Dittmer DP, Doerschuk CM. PMID: 21169470.
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    98. SYK Is a Tumor Suppressor In Pre-B Cell Acute Lymphoblastic Leukemia and Not a Therapeutic Target. Blood. 2010 Nov 19; 116(21):4199-4199. Carina Ng, Rahul Nahar, Emily Elliott, Clifford A. Lowell, Markus Muschen. .
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    99. Mechanisms of Pre-B Cell Receptor-Inactivation In Acute Lymphoblastic Leukemia. Blood. 2010 Nov 19; 116(21):147-147. Cihangir Duy, Daniel Nowak, Lars Klemm, Rahul Nahar, Carina Ng, Emily Elliott, Wolf-Karsten Hofmann, Nora Heisterkamp, Clifford A. Lowell, Phillip Koeffler, Markus Muschen. .
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    100. The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity. Immunity. 2010 Aug 27; 33(2):181-91. Tavares RM, Turer EE, Liu CL, Advincula R, Scapini P, Rhee L, Barrera J, Lowell CA, Utz PJ, Malynn BA, Ma A. PMID: 20705491.
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    101. Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J Exp Med. 2010 Aug 02; 207(8):1757-73. Scapini P, Hu Y, Chu CL, Migone TS, Defranco AL, Cassatella MA, Lowell CA. PMID: 20624892.
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    102. Interim results of a phase I trial of intraventricular rituximab plus methotrexate in recurrent CNS lymphoma: Macrophage polarization and acquired resistance to therapy. Journal of Clinical Oncology. 2010 May 20; 28(15_suppl):2532-2532. J. L. Rubenstein, C. Kadoch, V. S. Wong, W. Hyun, C. Lowell. .
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    103. An important role of the SRC family kinase Lyn in stimulating platelet granule secretion. J Biol Chem. 2010 Apr 23; 285(17):12559-70. Li Z, Zhang G, Liu J, Stojanovic A, Ruan C, Lowell CA, Du X. PMID: 20189992.
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    104. Management practices and phytoremediation by native grasses. Int J Phytoremediation. 2010 Feb; 12(2):200-14. Nedunuri KV, Lowell C, Meade W, Vonderheide AP, Shann JR. PMID: 20734616.
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    105. c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration. FEBS Lett. 2010 Jan 04; 584(1):15-21. Baruzzi A, Iacobucci I, Soverini S, Lowell CA, Martinelli G, Berton G. PMID: 19903482.
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    106. Macrophage Polarization and Acquired Resistance to Rituximab in CNS Lymphoma. Blood. 2009 Nov 20; 114(22):3749-3749. Cigall Kadoch, Valerie D. Wong, Tara Rambaldo, William Hyun, Clifford Lowell, James Rubenstein. .
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    107. Three-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysis. Blood. 2010 Feb 18; 115(7):1444-52. Cougoule C, Le Cabec V, Poincloux R, Al Saati T, Mège JL, Tabouret G, Lowell CA, Laviolette-Malirat N, Maridonneau-Parini I. PMID: 19897576.
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    108. The expanding roles of ITAM adapters FcRgamma and DAP12 in myeloid cells. Immunol Rev. 2009 Nov; 232(1):42-58. Hamerman JA, Ni M, Killebrew JR, Chu CL, Lowell CA. PMID: 19909355.
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    109. Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest. 2009 Nov; 119(11):3450-61. Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay MA. PMID: 19809160.
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    110. Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection. Blood. 2009 Nov 26; 114(23):4871-82. Van Ziffle JA, Lowell CA. PMID: 19797524.
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    111. Microarray kit analysis of cytokines in blood product units and segments. Transfusion. 2009 Nov; 49(11):2269-75. Weiskopf RB, Yau R, Sanchez R, Lowell C, Toy P. PMID: 19548981.
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    112. Leukocyte adhesion deficiency syndrome: a controversy solved. Immunol Cell Biol. 2009 Aug-Sep; 87(6):440-2. Abram CL, Lowell CA. PMID: 19417769.
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    113. Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model. Clin Cancer Res. 2009 Mar 15; 15(6):1989-97. Kadoch C, Dinca EB, Voicu R, Chen L, Nguyen D, Parikh S, Karrim J, Shuman MA, Lowell CA, Treseler PA, James CD, Rubenstein JL. PMID: 19276270.
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    114. The absence of Hck, Fgr, and Lyn tyrosine kinases augments lung innate immune responses to Pneumocystis murina. Infect Immun. 2009 May; 77(5):1790-7. Nelson MP, Metz AE, Li S, Lowell CA, Steele C. PMID: 19255189.
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    115. Multiple roles of Lyn kinase in myeloid cell signaling and function. Immunol Rev. 2009 Mar; 228(1):23-40. Scapini P, Pereira S, Zhang H, Lowell CA. PMID: 19290919.
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    116. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. Journal of Experimental Medicine. 2009 Feb 16; 206(2):i3-i3. Elsa-Noah N'Diaye, Catherine S. Branda, Steven S. Branda, Lisette Nevarez, Marco Colonna, Clifford Lowell, Jessica A. Hamerman, William E. Seaman. .
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    117. Erratum: Corrigendum: Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nature Immunology. 2009 Feb 1; 10(2):223-223. Jessica A Hamerman, Nadia K Tchao, Clifford A Lowell, Lewis L Lanier. .
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    118. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. J Cell Biol. 2009 Jan 26; 184(2):215-23. N'Diaye EN, Branda CS, Branda SS, Nevarez L, Colonna M, Lowell C, Hamerman JA, Seaman WE. PMID: 19171755.
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    119. Generation of a novel system for studying spleen tyrosine kinase function in macrophages and B cells. J Immunol. 2009 Jan 15; 182(2):988-98. Miller AL, Zhang C, Shokat KM, Lowell CA. PMID: 19124742.
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    120. The ins and outs of leukocyte integrin signaling. Annu Rev Immunol. 2009; 27:339-62. Abram CL, Lowell CA. PMID: 19302044.
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    121. Transmigration of neutrophils across inflamed endothelium is signaled through LFA-1 and Src family kinase. J Immunol. 2008 Dec 15; 181(12):8660-9. Sarantos MR, Zhang H, Schaff UY, Dixit N, Hayenga HN, Lowell CA, Simon SI. PMID: 19050286.
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    122. Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells. Immunity. 2008 Nov 14; 29(5):807-18. Ng G, Sharma K, Ward SM, Desrosiers MD, Stephens LA, Schoel WM, Li T, Lowell CA, Ling CC, Amrein MW, Shi Y. PMID: 18993083.
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    123. PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling. J Exp Med. 2008 Sep 29; 205(10):2339-47. Zarbock A, Abram CL, Hundt M, Altman A, Lowell CA, Ley K. PMID: 18794338.
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    124. Evaluation of the physiological significance of botrocetin/ von Willebrand factor in vitro signaling. J Thromb Haemost. 2008 Nov; 6(11):1915-22. Liu J, Joglekar M, Ware J, Fitzgerald ME, Lowell CA, Berndt MC, Gartner TK. PMID: 18752568.
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    125. Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase. J Leukoc Biol. 2008 Oct; 84(4):1141-50. Paul R, Obermaier B, Van Ziffle J, Angele B, Pfister HW, Lowell CA, Koedel U. PMID: 18625913.
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    126. Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway. Blood. 2008 Aug 15; 112(4):1139-46. Yin H, Liu J, Li Z, Berndt MC, Lowell CA, Du X. PMID: 18550847.
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    127. The diverse functions of Src family kinases in macrophages. Front Biosci. 2008 May 01; 13:4426-50. Abram CL, Lowell CA. PMID: 18508521.
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    128. Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5. J Clin Invest. 2008 Mar; 118(3):924-34. Xiao W, Hong H, Kawakami Y, Lowell CA, Kawakami T. PMID: 18246197.
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    129. Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRgamma. Eur J Immunol. 2008 Jan; 38(1):166-73. Chu CL, Yu YL, Shen KY, Lowell CA, Lanier LL, Hamerman JA. PMID: 18081038.
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    130. Immunoreceptor-like signaling by beta 2 and beta 3 integrins. Trends Cell Biol. 2007 Oct; 17(10):493-501. Jakus Z, Fodor S, Abram CL, Lowell CA, Mócsai A. PMID: 17913496.
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    131. Convergence of immunoreceptor and integrin signaling. Immunol Rev. 2007 Aug; 218:29-44. Abram CL, Lowell CA. PMID: 17624942.
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    132. TRALI--definition, mechanisms, incidence and clinical relevance. Best Pract Res Clin Anaesthesiol. 2007 Jun; 21(2):183-93. Toy P, Lowell C. PMID: 17650771.
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    133. Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1. Immunity. 2007 Jun; 26(6):773-83. Zarbock A, Lowell CA, Ley K. PMID: 17543554.
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    134. The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn. Blood. 2007 Oct 01; 110(7):2511-9. Hong H, Kitaura J, Xiao W, Horejsi V, Ra C, Lowell CA, Kawakami Y, Kawakami T. PMID: 17513616.
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    135. Cutting Edge: B cell receptor (BCR) cross-talk: the IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to Rottlerin, and depends on Lyn. J Immunol. 2007 Apr 15; 178(8):4726-30. Guo B, Blair D, Chiles TC, Lowell CA, Rothstein TL. PMID: 17404251.
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    136. The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine. J Immunol. 2007 Mar 15; 178(6):3874-85. Fumagalli L, Zhang H, Baruzzi A, Lowell CA, Berton G. PMID: 17339487.
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    137. The expanding role for ITAM-based signaling pathways in immune cells. Sci STKE. 2007 Mar 13; 2007(377):re2. Abram CL, Lowell CA. PMID: 17356173.
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    138. Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. J Exp Med. 2006 Dec 25; 203(13):2907-17. Xu X, Zhang D, Zhang H, Wolters PJ, Killeen NP, Sullivan BM, Locksley RM, Lowell CA, Caughey GH. PMID: 17158962.
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    139. Src family kinases mediate neutrophil adhesion to adherent platelets. Blood. 2007 Mar 15; 109(6):2461-9. Evangelista V, Pamuklar Z, Piccoli A, Manarini S, Dell'elba G, Pecce R, Martelli N, Federico L, Rojas M, Berton G, Lowell CA, Totani L, Smyth SS. PMID: 17095622.
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    140. Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat Immunol. 2006 Dec; 7(12):1326-33. Mócsai A, Abram CL, Jakus Z, Hu Y, Lanier LL, Lowell CA. PMID: 17086186.
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    141. Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils. Immunity. 2006 Aug; 25(2):285-95. Zhang H, Schaff UY, Green CE, Chen H, Sarantos MR, Hu Y, Wara D, Simon SI, Lowell CA. PMID: 16901726.
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    142. Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Immunity. 2006 Aug; 25(2):271-83. Hirahashi J, Mekala D, Van Ziffle J, Xiao L, Saffaripour S, Wagner DD, Shapiro SD, Lowell C, Mayadas TN. PMID: 16872848.
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    143. The Src family kinases Hck and Fgr are dispensable for inside-out, chemoattractant-induced signaling regulating beta 2 integrin affinity and valency in neutrophils, but are required for beta 2 integrin-mediated outside-in signaling involved in sustained adhesion. J Immunol. 2006 Jul 01; 177(1):604-11. Giagulli C, Ottoboni L, Caveggion E, Rossi B, Lowell C, Constantin G, Laudanna C, Berton G. PMID: 16785558.
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    144. Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis. Blood. 2006 Oct 15; 108(8):2562-8. Mermel CH, McLemore ML, Liu F, Pereira S, Woloszynek J, Lowell CA, Link DC. PMID: 16772601.
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    145. Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest. 2006 Jun; 116(6):1615-23. Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA. PMID: 16710475.
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    146. Lyn kinase promotes erythroblast expansion and late-stage development. Blood. 2006 Sep 01; 108(5):1524-32. Karur VG, Lowell CA, Besmer P, Agosti V, Wojchowski DM. PMID: 16705093.
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    147. Src-family kinases mediate an outside-in signal necessary for beta2 integrins to achieve full activation and sustain firm adhesion of polymorphonuclear leucocytes tethered on E-selectin. Biochem J. 2006 May 15; 396(1):89-98. Totani L, Piccoli A, Manarini S, Federico L, Pecce R, Martelli N, Cerletti C, Piccardoni P, Lowell CA, Smyth SS, Berton G, Evangelista V. PMID: 16433632.
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    148. A role for PKCtheta in outside-in alpha(IIb)beta3 signaling. J Thromb Haemost. 2006 Mar; 4(3):648-55. Soriani A, Moran B, de Virgilio M, Kawakami T, Altman A, Lowell C, Eto K, Shattil SJ. PMID: 16460447.
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    149. Rewiring phagocytic signal transduction. Immunity. 2006 Mar; 24(3):243-5. Lowell CA. PMID: 16546092.
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    150. Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI. J Immunol. 2006 Feb 15; 176(4):2421-9. Yu M, Lowell CA, Neel BG, Gu H. PMID: 16456001.
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    151. Beautiful blistering. Blood. 2006 Feb 1; 107(3):849-850. Clifford A. Lowell. .
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    152. Dual function for the adaptor MIST in IFN-gamma production by NK and CD4+NKT cells regulated by the Src kinase Fgr. Blood. 2006 May 01; 107(9):3647-55. Sasanuma H, Tatsuno A, Hidano S, Ohshima K, Matsuzaki Y, Hayashi K, Lowell CA, Kitamura D, Goitsuka R. PMID: 16439675.
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    153. Increased expression of genes linked to FcepsilonRI Signaling and to cytokine and chemokine production in Lyn-deficient mast cells. J Immunol. 2005 Dec 15; 175(12):7880-8. Hernandez-Hansen V, Bard JD, Tarleton CA, Wilder JA, Lowell CA, Wilson BS, Oliver JM. PMID: 16339523.
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    154. Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI. J Immunol. 2005 Nov 15; 175(10):6885-92. Xiao W, Nishimoto H, Hong H, Kitaura J, Nunomura S, Maeda-Yamamoto M, Kawakami Y, Lowell CA, Ra C, Kawakami T. PMID: 16272347.
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    155. Regulation of K-Cl cotransport by protein phosphatase 1alpha in mouse erythrocytes. Pflugers Arch. 2006 Mar; 451(6):760-8. De Franceschi L, Villa-Moruzzi E, Biondani A, Siciliano A, Brugnara C, Alper SL, Lowell CA, Berton G. PMID: 16283202.
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    156. G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth. Blood. 2006 Mar 01; 107(5):1847-56. Zhu QS, Xia L, Mills GB, Lowell CA, Touw IP, Corey SJ. PMID: 16282349.
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    157. The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4. Biochem Pharmacol. 2005 Oct 15; 70(8):1231-40. Lee JY, Lowell CA, Lemay DG, Youn HS, Rhee SH, Sohn KH, Jang B, Ye J, Chung JH, Hwang DH. PMID: 16140274.
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    158. The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation. J Immunol. 2005 Sep 01; 175(5):2880-9. Chu CL, Lowell CA. PMID: 16116174.
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    159. Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. Blood. 2005 Oct 01; 106(7):2543-50. Underhill DM, Rossnagle E, Lowell CA, Simmons RM. PMID: 15956283.
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    160. Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat Immunol. 2005 Jun; 6(6):579-86. Hamerman JA, Tchao NK, Lowell CA, Lanier LL. PMID: 15895090.
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    161. Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases. J Immunol. 2005 Apr 15; 174(8):4495-504. Kitaura J, Eto K, Kinoshita T, Kawakami Y, Leitges M, Lowell CA, Kawakami T. PMID: 15814670.
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    162. Src and Syk kinases: key regulators of phagocytic cell activation. Trends Immunol. 2005 Apr; 26(4):208-14. Berton G, Mócsai A, Lowell CA. PMID: 15797511.
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    163. Minimum conditions of major histocompatibility complex compatibility and recipient immune compromise required to establish donor white blood cell persistence in a murine transfusion model. Transfusion. 2005 Mar; 45(3):301-14. Lee TH, Wen L, Montalvo L, Esho O, Lowell C, Reed W, Busch M. PMID: 15752147.
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    164. The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B. Immunity. 2005 Feb; 22(2):235-46. Zhang H, Meng F, Chu CL, Takai T, Lowell CA. PMID: 15723811.
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    165. The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization. Exp Cell Res. 2005 Jan 15; 302(2):253-69. Continolo S, Baruzzi A, Majeed M, Caveggion E, Fumagalli L, Lowell CA, Berton G. PMID: 15561106.
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    167. Lyn Kinase Supports Primary Erythroid Progenitor Cell Development. Blood. 2004 Nov 16; 104(11):1622-1622. Vinit Karur, Bethany Vincent, Clifford Lowell, Don M. Wojchowski. .
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    169. Amplification of IFN-alpha-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors. Nat Immunol. 2004 Nov; 5(11):1181-9. Tassiulas I, Hu X, Ho H, Kashyap Y, Paik P, Hu Y, Lowell CA, Ivashkiv LB. PMID: 15467722.
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    170. Early divergence of Fc epsilon receptor I signals for receptor up-regulation and internalization from degranulation, cytokine production, and survival. J Immunol. 2004 Oct 01; 173(7):4317-23. Kitaura J, Xiao W, Maeda-Yamamoto M, Kawakami Y, Lowell CA, Kawakami T. PMID: 15383560.
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    171. Responses of neutrophils to anti-integrin antibodies depends on costimulation through low affinity Fc gamma Rs: full activation requires both integrin and nonintegrin signals. J Immunol. 2004 Aug 01; 173(3):2068-77. Jakus Z, Berton G, Ligeti E, Lowell CA, Mócsai A. PMID: 15265942.
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    172. Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury. J Clin Invest. 2004 Jul; 114(1):49-56. Chou WH, Choi DS, Zhang H, Mu D, McMahon T, Kharazia VN, Lowell CA, Ferriero DM, Messing RO. PMID: 15232611.
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    173. Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells. J Immunol. 2004 Jul 01; 173(1):100-12. Hernandez-Hansen V, Smith AJ, Surviladze Z, Chigaev A, Mazel T, Kalesnikoff J, Lowell CA, Krystal G, Sklar LA, Wilson BS, Oliver JM. PMID: 15210764.
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    174. Src-family kinases: rheostats of immune cell signaling. Mol Immunol. 2004 Jul; 41(6-7):631-43. Lowell CA. PMID: 15220000.
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    175. CXCL1/macrophage inflammatory protein-2-induced angiogenesis in vivo is mediated by neutrophil-derived vascular endothelial growth factor-A. J Immunol. 2004 Apr 15; 172(8):5034-40. Scapini P, Morini M, Tecchio C, Minghelli S, Di Carlo E, Tanghetti E, Albini A, Lowell C, Berton G, Noonan DM, Cassatella MA. PMID: 15067085.
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    176. The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc Natl Acad Sci U S A. 2004 Apr 20; 101(16):6158-63. Mócsai A, Humphrey MB, Van Ziffle JA, Hu Y, Burghardt A, Spusta SC, Majumdar S, Lanier LL, Lowell CA, Nakamura MC. PMID: 15073337.
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    177. SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophils. Immunity. 2003 Nov; 19(5):761-9. Newbrough SA, Mocsai A, Clemens RA, Wu JN, Silverman MA, Singer AL, Lowell CA, Koretzky GA. PMID: 14614862.
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    178. Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12911-6. Kitaura J, Song J, Tsai M, Asai K, Maeda-Yamamoto M, Mocsai A, Kawakami Y, Liu FT, Lowell CA, Barisas BG, Galli SJ, Kawakami T. PMID: 14569021.
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    179. The Src kinase Lyn is a negative regulator of mast cell proliferation. J Leukoc Biol. 2004 Jan; 75(1):143-51. Hernandez-Hansen V, Mackay GA, Lowell CA, Wilson BS, Oliver JM. PMID: 14525964.
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    180. Reduced dosage of Bruton's tyrosine kinase uncouples B cell hyperresponsiveness from autoimmunity in lyn-/- mice. J Immunol. 2003 Aug 15; 171(4):1850-8. Whyburn LR, Halcomb KE, Contreras CM, Lowell CA, Witte ON, Satterthwaite AB. PMID: 12902486.
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    181. The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling. J Immunol. 2003 Aug 01; 171(3):1319-27. Pereira S, Lowell C. PMID: 12874221.
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    182. Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading. Immunity. 2003 Jul; 19(1):95-104. Chen H, Mocsai A, Zhang H, Ding RX, Morisaki JH, White M, Rothfork JM, Heiser P, Colucci-Guyon E, Lowell CA, Gresham HD, Allen PM, Brown EJ. PMID: 12871642.
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    183. Expression and tyrosine phosphorylation of Cbl regulates macrophage chemokinetic and chemotactic movement. J Cell Physiol. 2003 May; 195(2):276-89. Caveggion E, Continolo S, Pixley FJ, Stanley ER, Bowtell DD, Lowell CA, Berton G. PMID: 12652654.
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    184. Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development. Nat Immunol. 2003 Mar; 4(3):274-9. Saijo K, Schmedt C, Su IH, Karasuyama H, Lowell CA, Reth M, Adachi T, Patke A, Santana A, Tarakhovsky A. PMID: 12563261.
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    185. G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells. Blood. 2003 May 15; 101(10):4155-63. Mócsai A, Zhang H, Jakus Z, Kitaura J, Kawakami T, Lowell CA. PMID: 12531806.
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    186. Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science. 2003 Jan 10; 299(5604):247-51. Abtahian F, Guerriero A, Sebzda E, Lu MM, Zhou R, Mocsai A, Myers EE, Huang B, Jackson DG, Ferrari VA, Tybulewicz V, Lowell CA, Lepore JJ, Koretzky GA, Kahn ML. PMID: 12522250.
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    187. Tumor necrosis factor-alpha-induced leukocyte adhesion and microvessel permeability. Am J Physiol Heart Circ Physiol. 2002 Dec; 283(6):H2420-30. Zeng M, Zhang H, Lowell C, He P. PMID: 12388263.
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    188. Fgr deficiency results in defective eosinophil recruitment to the lung during allergic airway inflammation. J Immunol. 2002 Jun 15; 168(12):6446-54. Vicentini L, Mazzi P, Caveggion E, Continolo S, Fumagalli L, Lapinet-Vera JA, Lowell CA, Berton G. PMID: 12055264.
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    189. Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J Cell Biol. 2002 Apr 15; 157(2):265-75. Obergfell A, Eto K, Mocsai A, Buensuceso C, Moores SL, Brugge JS, Lowell CA, Shattil SJ. PMID: 11940607.
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    191. Role of the Src family kinase Lyn in TxA2 production, adenosine diphosphate secretion, Akt phosphorylation, and irreversible aggregation in platelets stimulated with gamma-thrombin. Blood. 2002 Apr 01; 99(7):2442-7. Cho MJ, Pestina TI, Steward SA, Lowell CA, Jackson CW, Gartner TK. PMID: 11895777.
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    192. Lyn tyrosine kinase is important for IL-5-stimulated eosinophil differentiation. J Immunol. 2002 Feb 15; 168(4):1978-83. Stafford S, Lowell C, Sur S, Alam R. PMID: 11823534.
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    193. Role of Src kinases and Syk in Fcgamma receptor-mediated phagocytosis and phagosome-lysosome fusion. J Leukoc Biol. 2001 Nov; 70(5):801-11. Majeed M, Caveggion E, Lowell CA, Berton G. PMID: 11698501.
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    194. Non-immunogenic murine hepatocellular carcinoma Hepa1-6 cells expressing the membrane form of macrophage colony stimulating factor are rejected in vivo and lead to CD8+ T-cell immunity against the parental tumor. Mol Ther. 2001 Nov; 4(5):427-37. Dan Q, Sanchez R, Delgado C, Wepsic HT, Morgan K, Chen Y, Jeffes EW, Lowell CA, Morgan TR, Jadus MR. PMID: 11708879.
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    195. The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck. J Virol. 2001 Oct; 75(19):9378-92. Hanna Z, Weng X, Kay DG, Poudrier J, Lowell C, Jolicoeur P. PMID: 11533201.
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    197. A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice. J Immunol. 2001 Sep 01; 167(5):2469-78. Hasegawa M, Fujimoto M, Poe JC, Steeber DA, Lowell CA, Tedder TF. PMID: 11509585.
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    198. Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells. Blood. 2001 Jul 15; 98(2):343-50. O'Laughlin-Bunner B, Radosevic N, Taylor ML, DeBerry C, Metcalfe DD, Zhou M, Lowell C, Linnekin D. PMID: 11435302.
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    199. Resting murine neutrophils express functional alpha 4 integrins that signal through Src family kinases. J Immunol. 2001 Mar 15; 166(6):4115-23. Pereira S, Zhou M, Mócsai A, Lowell C. PMID: 11238661.
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    200. Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn. Curr Biol. 2001 Jan 09; 11(1):34-8. Yu CC, Yen TS, Lowell CA, DeFranco AL. PMID: 11166177.
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    201. Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway. Blood. 2000 Dec 15; 96(13):4246-53. Quek LS, Pasquet JM, Hers I, Cornall R, Knight G, Barnes M, Hibbs ML, Dunn AR, Lowell CA, Watson SP. PMID: 11110698.
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    209. Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharide-stimulated nitric oxide production in macrophages via interferon-beta. J Leukoc Biol. 2000 Mar; 67(3):405-14. Weinstein SL, Finn AJ, Davé SH, Meng F, Lowell CA, Sanghera JS, DeFranco AL. PMID: 10733102.
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    213. Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages. J Cell Sci. 1999 Nov; 112 ( Pt 22):4067-78. Suen PW, Ilic D, Caveggion E, Berton G, Damsky CH, Lowell CA. PMID: 10547366.
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    214. Integrin signalling in neutrophils and macrophages. Cell Signal. 1999 Sep; 11(9):621-35. Berton G, Lowell CA. PMID: 10530871.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    215. Integrin signal transduction in myeloid leukocytes. J Leukoc Biol. 1999 Mar; 65(3):313-20. Lowell CA, Berton G. PMID: 10080533.
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    216. Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck. J Immunol. 1999 Jan 15; 162(2):1120-6. Mócsai A, Ligeti E, Lowell CA, Berton G. PMID: 9916742.
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    217. Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways. J Exp Med. 1998 Sep 07; 188(5):833-44. Satterthwaite AB, Lowell CA, Khan WN, Sideras P, Alt FW, Witte ON. PMID: 9730885.
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    218. A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration. EMBO J. 1998 Aug 03; 17(15):4391-403. Meng F, Lowell CA. PMID: 9687507.
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    219. Positive and negative roles of the tyrosine kinase Lyn in B cell function. Semin Immunol. 1998 Aug; 10(4):299-307. DeFranco AL, Chan VW, Lowell CA. PMID: 9695186.
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    220. The molecular mechanism of B cell activation by toll-like receptor protein RP-105. J Exp Med. 1998 Jul 06; 188(1):93-101. Chan VW, Mecklenbräuker I, Su I, Texido G, Leitges M, Carsetti R, Lowell CA, Rajewsky K, Miyake K, Tarakhovsky A. PMID: 9653087.
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    221. Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr. Proc Natl Acad Sci U S A. 1998 Jun 23; 95(13):7580-4. Lowell CA, Berton G. PMID: 9636192.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    222. Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes. Curr Biol. 1998 May 07; 8(10):545-53. Chan VW, Lowell CA, DeFranco AL. PMID: 9601638.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    223. Macrophages kill T9 glioma tumor cells bearing the membrane isoform of macrophage colony stimulating factor through a phagocytosis-dependent pathway. J Immunol. 1998 Jan 01; 160(1):361-8. Jadus MR, Williams CC, Avina MD, Ly M, Kim S, Liu Y, Narasaki R, Lowell CA, Wepsic HT. PMID: 9551992.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    224. Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice. Genes Dev. 1997 Nov 01; 11(21):2835-44. Schwartzberg PL, Xing L, Hoffmann O, Lowell CA, Garrett L, Boyce BF, Varmus HE. PMID: 9353253.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    225. A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages. J Exp Med. 1997 Oct 06; 186(7):1027-39. Crowley MT, Costello PS, Fitzer-Attas CJ, Turner M, Meng F, Lowell C, Tybulewicz VL, DeFranco AL. PMID: 9314552.
      View in: PubMed   Mentions: 127     Fields:    Translation:AnimalsCells
    226. Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity. 1997 Jul; 7(1):69-81. Chan VW, Meng F, Soriano P, DeFranco AL, Lowell CA. PMID: 9252121.
      View in: PubMed   Mentions: 132     Fields:    Translation:AnimalsCells
    227. Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn. J Exp Med. 1997 May 05; 185(9):1661-70. Meng F, Lowell CA. PMID: 9151903.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    228. Deficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport. J Clin Invest. 1997 Jan 15; 99(2):220-7. De Franceschi L, Fumagalli L, Olivieri O, Corrocher R, Lowell CA, Berton G. PMID: 9005990.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    229. Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories. Genes Dev. 1996 Aug 01; 10(15):1845-57. Lowell CA, Soriano P. PMID: 8756343.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    230. Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions. J Cell Biol. 1996 May; 133(4):895-910. Lowell CA, Fumagalli L, Berton G. PMID: 8666673.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
    231. Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis. Blood. 1996 Mar 01; 87(5):1780-92. Lowell CA, Niwa M, Soriano P, Varmus HE. PMID: 8634424.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    232. Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis. Blood. 1996 Mar 1; 87(5):1780-1792. CA Lowell, M Niwa, P Soriano, HE Varmus. .
      View in: Publisher Site   Mentions:
    233. Neutrophil activation by adhesion: mechanisms and pathophysiological implications. Int J Clin Lab Res. 1996; 26(3):160-77. Berton G, Yan SR, Fumagalli L, Lowell CA. PMID: 8905448.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    234. Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. Genes Dev. 1994 Feb 15; 8(4):387-98. Lowell CA, Soriano P, Varmus HE. PMID: 8125254.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    235. Cancer genes and hematopoiesis. Blood. 1994 Jan 01; 83(1):5-9. Varmus HE, Lowell CA. PMID: 8274752.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    236. Mapping of the Epstein-Barr virus and C3dg binding sites to a common domain on complement receptor type 2. J Exp Med. 1989 Dec 01; 170(6):1931-46. Lowell CA, Klickstein LB, Carter RH, Mitchell JA, Fearon DT, Ahearn JM. PMID: 2479703.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    237. Sucrose-metabolizing enzymes in transport tissues and adjacent sink structures in developing citrus fruit. Plant Physiol. 1989 Aug; 90(4):1394-402. Lowell CA, Tomlinson PT, Koch KE. PMID: 16666942.
      View in: PubMed   Mentions: 24     Fields:    
    238. Fenoprofen-induced immune hemolysis. Difficulties in diagnosis and complications in compatibility testing. Am J Clin Pathol. 1988 Mar; 89(3):410-4. Shirey RS, Morton SJ, Lawton KB, Lowell C, Kickler TS, Ness PM. PMID: 3348176.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    239. Structure of the murine serum amyloid A gene family. Gene conversion. J Biol Chem. 1986 Jun 25; 261(18):8442-52. Lowell CA, Potter DA, Stearman RS, Morrow JF. PMID: 3013853.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    240. Transcriptional regulation of serum amyloid A gene expression. J Biol Chem. 1986 Jun 25; 261(18):8453-61. Lowell CA, Stearman RS, Morrow JF. PMID: 2424896.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    241. The sequence and structure of a new serum amyloid A gene. Nucleic Acids Res. 1986 Jan 24; 14(2):797-809. Stearman RS, Lowell CA, Peltzman CG, Morrow JF. PMID: 3003697.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    242. Regulation of synthesis of amyloid A-related protein. Ann N Y Acad Sci. 1982; 389:106-15. Stearman RS, Lowell CA, Pearson WR, Morrow JF. PMID: 6953913.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    243. Mechanism of mitochondrial DNA replication in mouse L-cells. Replication of unicircular dimer molecules. J Mol Biol. 1981 May 05; 148(1):77-93. Bogenhagen D, Lowell C, Clayton DA. PMID: 7310869.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    244. S1 nuclease-specific nicking of mitochondrial DNA containing displacement loops. Anal Biochem. 1978 Dec; 91(2):521-31. Lowell C, Bogenhagen D, Clayton DA. PMID: 9762139.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    245. Topical anesthetic effectiveness. An old and new product evaluated. N Y J Dent. 1972 Nov; 38(9):549-50. Howitt JW, Lowell C. PMID: 4562117.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    246. Topical anesthetic effectiveness. An old and new product evaluated. N Y State Dent J. 1972 Nov; 38(9):549-50. Howitt JW, Lowell C. PMID: 4578243.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
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