Clifford Lowell, MD, PhD

Title(s)Professor, Laboratory Medicine
SchoolSchool of Medicine
Address533 Parnassus Avenue
San Francisco CA 94117
Phone415-476-2963
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    Other Positions
    Title(s)Chair, Laboratory Medicine


    Collapse Biography 
    Collapse Education and Training
    Stanford UniversityBS1979Biology
    Johns Hopkins UniversityMD - PhD1986School of Medicine
    Johns Hopkins HospitalOsler Medical House Officier1989Medicine
    University of California, San FranciscoClinical Fellowship 1992Oncology
    University of California, San FranciscoPost-Doctoral Research Fellowship1995Laboratory: Harold Varmus
    Collapse Awards and Honors
    LLS2001Leukemia/Lymphoma Society Scholar
    FASEB2009Elected FASEB conference organizer
    Universite du Quebec2014Elected Advisory Board Neutrophil Immunity
    UCSF2015Distinguished Professorship
    AAP2021Elected American Association of Physicians

    Collapse Overview 
    Collapse Overview
    The Lowell laboratory studies tyrosine kinase and phosphatase based signal transduction in innate immune cells. Our general approach involves examination of innate immune function in knockout mice lacking various members of the Src-family or Syk family of tyrosine kinases. Many of these studies also involve use of mice lacking these kinases in specific hematopoietic lineages, such as neutrophils, macrophages or DCs, generated through Cre/Lox technology. We have also used this approach to study other tyrosine kinases (Pyk2/Fak) and intracellular signaling molecules (WASp, STIM1, STIM2) in innate immune cells. Our major findings have illuminated the function of Src-family and Syk kinases in leukocyte integrin signaling – loss of these kinases results in significant defects in inflammatory and host defense functions mediated by integrins. We have found that leukocyte integrin signaling utilizes the same intracellular pathways initiated by classical immunoreceptors (such as FcγRs) by co-opting ITAM-containing adapter proteins. We have also demonstrated the important ways these kinases regulate innate immune cells in the setting of autoimmune and inflammatory diseases, using the Lyn kinase-deficient model. Ongoing studies also involve examination of cytoplasmic tyrosine phosphatases (mainly SHP1) in the counter regulation tyrosine kinases, especially in the setting of hematopoietic malignancy and inflammatory disease. Recent publications highlight the role of SHP1, as a negative regulator of anti-tumor immunity, as well as the role of integrin signaling adapter protein SKAP2 in human autoimmune disease, in particular type 1 diabetes. Publications total = 228; h-index 97.

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of Innate Immune Signaling by Lyn Kinase
    NIH R01AI113272Feb 1, 2015 - Jan 31, 2021
    Role: Principal Investigator
    Signal Transduction in the Immune System-FASEB Summer Conference
    NIH R13AI084313Jun 21, 2009 - Jun 29, 2009
    Role: Principal Investigator
    Innate immune regulation of inflammation and adaptive immunity
    NIH P01AI078869Jul 15, 2008 - Jun 30, 2014
    Role: Co-Investigator
    FASEB Summer Conference on Signal Transduction in the Immune System
    NIH R13AI074219Jun 1, 2007 - May 31, 2008
    Role: Principal Investigator
    Transfusion and Lung Injury
    NIH P50HL081027Sep 30, 2005 - Aug 31, 2011
    Role: Co-Investigator
    Mechanisms of Neutrophil Activation
    NIH R01AI065495Jul 1, 2005 - Jan 31, 2019
    Role: Principal Investigator
    Proximal Signaling Events in Leukocyte Integrin Function
    NIH R03TW006831Aug 15, 2004 - Jul 31, 2008
    Role: Principal Investigator
    Signaling by Cytoplasmic Tyrosine Kinases in Leukocytes
    NIH R01DK058066Jul 1, 2001 - Jun 30, 2006
    Role: Principal Investigator
    Signaling by Cytoplasmic Tyrosine Kinases in Leukocytes
    NIH R01AI068150Aug 1, 2000 - Jan 31, 2018
    Role: Principal Investigator
    TRANSFUSION BIOLOGY AND MEDICINE
    NIH P50HL054476Feb 1, 1996 - Dec 31, 2006
    Role: Co-Investigator
    MURINE MODELS TO INVESTIGATE THE HEMATOLOGIC SYSTEM
    NIH P01DK050267Aug 15, 1995 - Jul 31, 2001
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Neutrophils in acute inflammation - current concepts and translational implications. Blood. 2021 Oct 08. Margraf A, Lowell CA, Zarbock A. PMID: 34624098.
      View in: PubMed   Mentions:    Fields:    
    2. Signal Integration by Translocation and Phosphorylation of PKCδ in the B Cell Alternate Pathway. J Immunol. 2021 Nov 01; 207(9):2288-2296. Khan N, Hu Y, Lowell CA, Rothstein TL. PMID: 34588218.
      View in: PubMed   Mentions:    Fields:    
    3. HIV-1 Nef Induces Hck/Lyn-Dependent Expansion of Myeloid-Derived Suppressor Cells Associated with Elevated Interleukin-17/G-CSF Levels. J Virol. 2021 08 10; 95(17):e0047121. Priceputu E, Cool M, Bouchard N, Caceres-Cortes JR, Lowell CA, Hanna Z, Jolicoeur P. PMID: 34106001.
      View in: PubMed   Mentions:    Fields:    
    4. Diabetes With Multiple Autoimmune and Inflammatory Conditions Linked to an Activating SKAP2 Mutation. Diabetes Care. 2021 08; 44(8):1816-1825. Rutsch N, Chamberlain CE, Dixon W, Spector L, Letourneau-Freiberg LR, Lwin WW, Philipson LH, Zarbock A, Saintus K, Wang J, German MS, Anderson MS, Lowell CA. PMID: 34172489.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. 1126-P: Activating SKAP2 Mutation Linked to Diabetes with Multiple Autoimmune and Inflammatory Conditions. Diabetes. 2021 Jun 21; 70(Supplement 1):1126-p. CHAMBERLAIN CC, RUTSCH RN, DIXON DW, LETOURNEAU-FREIBERG LL, PHILIPSON PL, GERMAN GM, ANDERSON AM, LOWELL LC. .
      View in: Publisher Site   Mentions:
    6. Neutrophil-specific deletion of Syk results in recruitment-independent stabilization of the barrier and a long-term improvement in cognitive function after traumatic injury to the developing brain. Neurobiol Dis. 2021 09; 157:105430. Trivedi A, Tercovich KG, Casbon AJ, Raber J, Lowell C, Noble-Haeusslein LJ. PMID: 34153467.
      View in: PubMed   Mentions:    Fields:    
    7. Inhibitory affinity modulation of FcγRIIA ligand binding by glycosphingolipids by inside-out signaling. Cell Rep. 2021 May 18; 35(7):109142. Okubo K, Brenner MD, Cullere X, Saggu G, Patchen ML, Bose N, Mihori S, Yuan Z, Lowell CA, Zhu C, Mayadas TN. PMID: 34010642.
      View in: PubMed   Mentions: 2     Fields:    
    8. A CD22-Shp1 phosphatase axis controls integrin ß 7 display and B cell function in mucosal immunity. The FASEB Journal. 2021 May 14; 35(S1). Ballet BR, Brennan BM, Brandl BC, Feng FN, Berri BJ, Cheng CJ, Ocón OB, Alborzian Deh Sheikh AA, Marki MA, Bi BY, Abram AC, Lowell LC, Tsubata TT, Greenberg GH, Macauley MM, Ley LK, Nitschke NL, Butcher BE. .
      View in: Publisher Site   Mentions:
    9. A CD22-Shp1 phosphatase axis controls integrin β7 display and B cell function in mucosal immunity. Nat Immunol. 2021 03; 22(3):381-390. Ballet R, Brennan M, Brandl C, Feng N, Berri J, Cheng J, Ocón B, Alborzian Deh Sheikh A, Marki A, Bi Y, Abram CL, Lowell CA, Tsubata T, Greenberg HB, Macauley MS, Ley K, Nitschke L, Butcher EC. PMID: 33589816.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. A neutrophil subset defined by intracellular olfactomedin 4 is associated with mortality in sepsis. Am J Physiol Lung Cell Mol Physiol. 2021 05 01; 320(5):L892-L902. Kangelaris KN, Clemens R, Fang X, Jauregui A, Liu T, Vessel K, Deiss T, Sinha P, Leligdowicz A, Liu KD, Zhuo H, Alder MN, Wong HR, Calfee CS, Lowell C, Matthay MA. PMID: 33355521.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsCTClinical Trials
    11. Complement activation on endothelium initiates antibody-mediated acute lung injury. J Clin Invest. 2020 11 02; 130(11):5909-5923. Cleary SJ, Kwaan N, Tian JJ, Calabrese DR, Mallavia B, Magnen M, Greenland JR, Urisman A, Singer JP, Hays SR, Kukreja J, Hay AM, Howie HL, Toy P, Lowell CA, Morrell CN, Zimring JC, Looney MR. PMID: 32730229.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    12. Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity. Front Immunol. 2020; 11:576310. Myers DR, Abram CL, Wildes D, Belwafa A, Welsh AMN, Schulze CJ, Choy TJ, Nguyen T, Omaque N, Hu Y, Singh M, Hansen R, Goldsmith MA, Quintana E, Smith JAM, Lowell CA. PMID: 33133093.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    13. ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defense. Proc Natl Acad Sci U S A. 2020 09 29; 117(39):24403-24414. Grimes D, Johnson R, Pashos M, Cummings C, Kang C, Sampedro GR, Tycksen E, McBride HJ, Sah R, Lowell CA, Clemens RA. PMID: 32929002.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    14. The Ubiquitin-Modifying Enzyme A20 Terminates C-Type Lectin Receptor Signals and Is a Suppressor of Host Defense against Systemic Fungal Infection. Infect Immun. 2020 08 19; 88(9). Liang J, Zhang JJ, Huang HI, Kanayama M, Youssef N, Jin YJ, Reyes EY, Abram CL, Yang S, Lowell CA, Wang D, Shao L, Shinohara ML, Zhang JY, Hammer GE. PMID: 32540868.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    15. Inhibition of the SRC Kinase HCK Impairs STAT3-Dependent Gastric Tumor Growth in Mice. Cancer Immunol Res. 2020 04; 8(4):428-435. Poh AR, Dwyer AR, Eissmann MF, Chand AL, Baloyan D, Boon L, Murrey MW, Whitehead L, O'Brien M, Lowell CA, Putoczki TL, Pixley FJ, O'Donoghue RJJ, Ernst M. PMID: 31992566.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    16. Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils. J Clin Invest. 2020 01 02; 130(1):389-403. Mahiddine K, Blaisdell A, Ma S, Créquer-Grandhomme A, Lowell CA, Erlebacher A. PMID: 31600172.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    17. Src family kinase-mediated vesicle trafficking is critical for neutrophil basement membrane penetration. Haematologica. 2020 07; 105(7):1845-1856. Rohwedder I, Kurz ARM, Pruenster M, Immler R, Pick R, Eggersmann T, Klapproth S, Johnson JL, Alsina SM, Lowell CA, Mócsai A, Catz SD, Sperandio M. PMID: 31699792.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    18. L-selectin shedding affects bacterial clearance in the lung: a new regulatory pathway for integrin outside-in signaling. Blood. 2019 10 24; 134(17):1445-1457. Cappenberg A, Margraf A, Thomas K, Bardel B, McCreedy DA, Van Marck V, Mellmann A, Lowell CA, Zarbock A. PMID: 31366620.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    19. CARD9 mediates dendritic cell-induced development of Lyn deficiency-associated autoimmune and inflammatory diseases. Sci Signal. 2019 10 08; 12(602). Ma J, Abram CL, Hu Y, Lowell CA. PMID: 31594855.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    20. CRAC channel regulation of innate immune cells in health and disease. Cell Calcium. 2019 03; 78:56-65. Clemens RA, Lowell CA. PMID: 30641250.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    21. Early Targeting of L-Selectin on Leukocytes Promotes Recovery after Spinal Cord Injury, Implicating Novel Mechanisms of Pathogenesis. eNeuro. 2018 Jul-Aug; 5(4). McCreedy DA, Lee S, Sontag CJ, Weinstein P, Olivas AD, Martinez AF, Fandel TM, Trivedi A, Lowell CA, Rosen SD, Noble-Haeusslein LJ. PMID: 30225356.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    22. Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma. Blood Adv. 2018 07 10; 2(13):1595-1607. Rubenstein JL, Geng H, Fraser EJ, Formaker P, Chen L, Sharma J, Killea P, Choi K, Ventura J, Kurhanewicz J, Lowell C, Hwang J, Treseler P, Sneed PK, Li J, Wang X, Chen N, Gangoiti J, Munster PN, Damato B. PMID: 29986852.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCTClinical Trials
    23. PRN473, an inhibitor of Bruton's tyrosine kinase, inhibits neutrophil recruitment via inhibition of macrophage antigen-1 signalling. Br J Pharmacol. 2018 02; 175(3):429-439. Herter JM, Margraf A, Volmering S, Correia BE, Bradshaw JM, Bisconte A, Hill RJ, Langrish CL, Lowell CA, Zarbock A. PMID: 29130484.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    24. Neutrophils: Their Role in Innate and Adaptive Immunity 2017. J Immunol Res. 2017; 2017:9748345. Rosales C, Lowell CA, Schnoor M, Uribe-Querol E. PMID: 29238732.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    25. B cell autoimmunity at the extremes. Nat Immunol. 2017 09 19; 18(10):1065-1066. Zikherman J, Lowell CA. PMID: 28926534.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    26. Efficiency and Specificity of Gene Deletion in Lung Epithelial Doxycycline-Inducible Cre Mice. Am J Respir Cell Mol Biol. 2017 08; 57(2):248-257. Sinha M, Lowell CA. PMID: 28287822.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    27. STIM1 and STIM2 cooperatively regulate mouse neutrophil store-operated calcium entry and cytokine production. Blood. 2017 09 28; 130(13):1565-1577. Clemens RA, Chong J, Grimes D, Hu Y, Lowell CA. PMID: 28724541.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    28. Role of MyD88 signaling in the imiquimod-induced mouse model of psoriasis: focus on innate myeloid cells. J Leukoc Biol. 2017 09; 102(3):791-803. Costa S, Marini O, Bevilacqua D, DeFranco AL, Hou B, Lonardi S, Vermi W, Rodegher P, Panato A, Tagliaro F, Lowell CA, Cassatella MA, Girolomoni G, Scapini P. PMID: 28642279.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    29. Shp1 function in myeloid cells. J Leukoc Biol. 2017 09; 102(3):657-675. Abram CL, Lowell CA. PMID: 28606940.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    30. Differentiating pulmonary transfusion reactions using recipient and transfusion factors. Transfusion. 2017 07; 57(7):1684-1690. Roubinian NH, Looney MR, Keating S, Kor DJ, Lowell CA, Gajic O, Hubmayr R, Gropper M, Koenigsberg M, Wilson GA, A Matthay M, Toy P, Murphy EL, TRALI Study Group . PMID: 28470756.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    31. SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin. Nature. 2017 04 27; 544(7651):493-497. Chen J, Zhong MC, Guo H, Davidson D, Mishel S, Lu Y, Rhee I, Pérez-Quintero LA, Zhang S, Cruz-Munoz ME, Wu N, Vinh DC, Sinha M, Calderon V, Lowell CA, Danska JS, Veillette A. PMID: 28424516.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    32. Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression. Cancer Cell. 2017 04 10; 31(4):563-575.e5. Poh AR, Love CG, Masson F, Preaudet A, Tsui C, Whitehead L, Monard S, Khakham Y, Burstroem L, Lessene G, Sieber O, Lowell C, Putoczki TL, O'Donoghue RJJ, Ernst M. PMID: 28399411.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    33. Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions. J Exp Med. 2017 03 06; 214(3):851-874. Boras M, Volmering S, Bokemeyer A, Rossaint J, Block H, Bardel B, Van Marck V, Heitplatz B, Kliche S, Reinhold A, Lowell C, Zarbock A. PMID: 28183734.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    34. Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9. PLoS One. 2016; 11(12):e0167693. Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM, DeFranco AL. PMID: 27977701.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    35. Targeting NF-KB Activation in Novel Intracranial Models of CNS Lymphoma. Blood. 2016 Dec 2; 128(22):777-777. Geng GH, Gao GH, Kadoch KC, Lu LM, Chen CL, Anjum AR, Drew DL, Degorce DS, Dillman DK, Mayo MM, Anderson AS, Collins CC, Lowell LC, Rubenstein RJ. .
      View in: Publisher Site   Mentions:
    36. Isolation of Highly Pure Primary Mouse Alveolar Epithelial Type II Cells by Flow Cytometric Cell Sorting. Bio Protoc. 2016 Nov 20; 6(22). Sinha M, Lowell CA. PMID: 28180137.
      View in: PubMed   Mentions:
    37. Leishmania Uses Mincle to Target an Inhibitory ITAM Signaling Pathway in Dendritic Cells that Dampens Adaptive Immunity to Infection. Immunity. 2016 10 18; 45(4):788-801. Iborra S, Martínez-López M, Cueto FJ, Conde-Garrosa R, Del Fresno C, Izquierdo HM, Abram CL, Mori D, Campos-Martín Y, Reguera RM, Kemp B, Yamasaki S, Robinson MJ, Soto M, Lowell CA, Sancho D. PMID: 27742545.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    38. LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity. J Clin Invest. 2016 10 03; 126(10):3758-3771. Proekt I, Miller CN, Jeanne M, Fasano KJ, Moon JJ, Lowell CA, Gould DB, Anderson MS, DeFranco AL. PMID: 27571405.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    39. Downregulation of the Syk Signaling Pathway in Intestinal Dendritic Cells Is Sufficient To Induce Dendritic Cells That Inhibit Colitis. J Immunol. 2016 10 01; 197(7):2948-57. Hang L, Blum AM, Kumar S, Urban JF, Mitreva M, Geary TG, Jardim A, Stevenson MM, Lowell CA, Weinstock JV. PMID: 27559049.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    40. MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase. PLoS Pathog. 2016 08; 12(8):e1005787. Wang H, Li M, Hung CY, Sinha M, Lee LM, Wiesner DL, LeBert V, Lerksuthirat T, Galles K, Suresh M, DeFranco AL, Lowell CA, Klein BS, Wüthrich M. PMID: 27542117.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    41. Immune Defense Protein Expression in Highly Purified Mouse Lung Epithelial Cells. Am J Respir Cell Mol Biol. 2016 06; 54(6):802-13. Sinha M, Lowell CA. PMID: 26574781.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    42. FleA Expression in Aspergillus fumigatus Is Recognized by Fucosylated Structures on Mucins and Macrophages to Prevent Lung Infection. PLoS Pathog. 2016 Apr; 12(4):e1005555. Kerr SC, Fischer GJ, Sinha M, McCabe O, Palmer JM, Choera T, Lim FY, Wimmerova M, Carrington SD, Yuan S, Lowell CA, Oscarson S, Keller NP, Fahy JV. PMID: 27058347.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    43. Neutrophils in animal models of autoimmune disease. Semin Immunol. 2016 04; 28(2):174-86. Németh T, Mócsai A, Lowell CA. PMID: 27067180.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    44. Corrigendum: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2016 06 02; 534(7605):138. Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M. PMID: 26958840.
      View in: PubMed   Mentions:    Fields:    
    45. Neutrophils: Their Role in Innate and Adaptive Immunity. J Immunol Res. 2016; 2016:1469780. Rosales C, Demaurex N, Lowell CA, Uribe-Querol E. PMID: 27006954.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    46. The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation. Immunity. 2016 Jan 19; 44(1):73-87. Volmering S, Block H, Boras M, Lowell CA, Zarbock A. PMID: 26777396.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    47. Integrins: Regulation of Adhesion and Downstream Signaling. Encyclopedia of Immunobiology. 2016 Jan 1; 72-82. Lowell LC. .
      View in: Publisher Site   Mentions:
    48. Targeted Activation of B Cell Autoimmunity Checkpoints in Acute Lymphoblastic Leukemia. Blood. 2015 Dec 3; 126(23):3716-3716. Chen CZ, Geng GH, Lowell LC, Weiss WA, Hunger HS, Melnick MA, Muschen MM. .
      View in: Publisher Site   Mentions:
    49. LynA regulates an inflammation-sensitive signaling checkpoint in macrophages. Elife. 2015 Oct 30; 4. Freedman TS, Tan YX, Skrzypczynska KM, Manz BN, Sjaastad FV, Goodridge HS, Lowell CA, Weiss A. PMID: 26517880.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    50. Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses. Immunity. 2015 Oct 20; 43(4):764-75. Yi T, Li J, Chen H, Wu J, An J, Xu Y, Hu Y, Lowell CA, Cyster JG. PMID: 26453377.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    51. Lung Ischemia-Reperfusion is a Sterile Inflammatory Process Influenced by Commensal Microbiota in Mice. Shock. 2015 Sep; 44(3):272-9. Prakash A, Sundar SV, Zhu YG, Tran A, Lee JW, Lowell C, Hellman J. PMID: 26196836.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    52. The Src-Family Kinases Hck and Fgr Regulate Early Lipopolysaccharide-Induced Myeloid Cell Recruitment into the Lung and Their Ability To Secrete Chemokines. J Immunol. 2015 Sep 01; 195(5):2383-95. Mazzi P, Caveggion E, Lapinet-Vera JA, Lowell CA, Berton G. PMID: 26232427.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    53. Cross-Talk between Shp1 and PIPKIγ Controls Leukocyte Recruitment. J Immunol. 2015 Aug 01; 195(3):1152-61. Stadtmann A, Block H, Volmering S, Abram C, Sohlbach C, Boras M, Lowell CA, Zarbock A. PMID: 26101325.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    54. Intracellular signalling during neutrophil recruitment. Cardiovasc Res. 2015 Aug 01; 107(3):373-85. Mócsai A, Walzog B, Lowell CA. PMID: 25998986.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    55. Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2015 May 21; 521(7552):357-61. Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M. PMID: 25799995.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    56. A2.21 The role of HCK, FGR and LYN in in vivo inflammation in mice. Annals of the Rheumatic Diseases. 2015 Mar 1; 74(Suppl 1):a24-a24. Kovács KM, Németh NT, Jakus JZ, Sitaru SC, Simon SE, Futosi FK, Botz BB, Helyes HZ, Lowell LC, Mócsai MA. .
      View in: Publisher Site   Mentions:
    57. Store-operated calcium signaling in neutrophils. J Leukoc Biol. 2015 Oct; 98(4):497-502. Clemens RA, Lowell CA. PMID: 25714804.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    58. Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions. Transfusion. 2015 Aug; 55(8):1838-46. Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL, TRALI Study Group . PMID: 25702590.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    59. Recipient clinical risk factors predominate in possible transfusion-related acute lung injury. Transfusion. 2015 May; 55(5):947-52. Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, Sanchez Rosen R, Looney MR. PMID: 25488517.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    60. Harnessing Negative B Cell Selection to Overcome Drug-Resistance in Acute Lymphoblastic Leukemia. Blood. 2014 Dec 6; 124(21):792-792. Chen CZ, Shojaee SS, Geng GH, Lee LJ, Buchner BM, Klemm KL, Lowell LC, Paietta PE, Willman WC, Carroll CW, Melnick MA, Jung JJ, Jumaa JH, Coligan CJ, Bolland BS, Mak MT, Muschen MM. .
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    61. The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment. J Exp Med. 2014 Sep 22; 211(10):1993-2011. Kovács M, Németh T, Jakus Z, Sitaru C, Simon E, Futosi K, Botz B, Helyes Z, Lowell CA, Mócsai A. PMID: 25225462.
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    62. Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*. Crit Care Med. 2014 Jul; 42(7):1676-87. Looney MR, Roubinian N, Gajic O, Gropper MA, Hubmayr RD, Lowell CA, Bacchetti P, Wilson G, Koenigsberg M, Lee DC, Wu P, Grimes B, Norris PJ, Murphy EL, Gandhi MJ, Winters JL, Mair DC, Schuller RM, Hirschler NV, Rosen RS, Matthay MA, Toy P, Transfusion-Related Acute Lung Injury Study Group . PMID: 24776608.
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    63. Actin cytoskeleton reorganization by Syk regulates Fcγ receptor responsiveness by increasing its lateral mobility and clustering. Dev Cell. 2014 Jun 09; 29(5):534-546. Jaumouillé V, Farkash Y, Jaqaman K, Das R, Lowell CA, Grinstein S. PMID: 24914558.
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    64. ROS-triggered phosphorylation of complex II by Fgr kinase regulates cellular adaptation to fuel use. Cell Metab. 2014 Jun 03; 19(6):1020-33. Acín-Pérez R, Carrascoso I, Baixauli F, Roche-Molina M, Latorre-Pellicer A, Fernández-Silva P, Mittelbrunn M, Sanchez-Madrid F, Pérez-Martos A, Lowell CA, Manfredi G, Enríquez JA. PMID: 24856931.
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    65. Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice. J Immunol Methods. 2014 Jun; 408:89-100. Abram CL, Roberge GL, Hu Y, Lowell CA. PMID: 24857755.
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    66. Molecular editing of cellular responses by the high-affinity receptor for IgE. Science. 2014 Feb 28; 343(6174):1021-5. Suzuki R, Leach S, Liu W, Ralston E, Scheffel J, Zhang W, Lowell CA, Rivera J. PMID: 24505132.
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    67. STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense. Blood. 2014 Apr 03; 123(14):2238-49. Zhang H, Clemens RA, Liu F, Hu Y, Baba Y, Theodore P, Kurosaki T, Lowell CA. PMID: 24493668.
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    68. Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice. J Immunol. 2014 Feb 01; 192(3):875-85. Hua Z, Gross AJ, Lamagna C, Ramos-Hernández N, Scapini P, Ji M, Shao H, Lowell CA, Hou B, DeFranco AL. PMID: 24379120.
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    69. B cell-specific loss of Lyn kinase leads to autoimmunity. J Immunol. 2014 Feb 01; 192(3):919-28. Lamagna C, Hu Y, DeFranco AL, Lowell CA. PMID: 24376269.
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    70. Inhibitory Receptors and Phosphatases Enable Oncogenic Tyrosine Kinase Signaling In B Cell Lineage Leukemia. Blood. 2013 Nov 15; 122(21):229-229. Chen CZ, Shojaee SS, Geng GH, Lee LJ, Buchner BM, Klemm KL, Lowell LC, Paietta PE, Willman WC, Carroll CW, Melnick MA, Jung JJ, Jumaa JH, Coligan CJ, Bolland BS, Mak MT, Muschen MM. .
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    71. Novel Intracranial Xenografts Of CNS Lymphoma Implicate a Role For Cereblon As a Mediator Of Lenalidomide Efficacy. Blood. 2013 Nov 15; 122(21):374-374. Gao GH, Anderson AS, Kadoch KC, Maiti MM, Chen CL, Yao YD, Melkus MG, Wang WM, Ren RY, Breider BM, Heise HC, Lowell LC, Collins CC, Rubenstein RJ. .
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    72. Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma. Clin Cancer Res. 2014 Feb 15; 20(4):1029-41. Kadoch C, Li J, Wong VS, Chen L, Cha S, Munster P, Lowell CA, Shuman MA, Rubenstein JL. PMID: 24190981.
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    73. A critical role for Lyn kinase in strengthening endothelial integrity and barrier function. Blood. 2013 Dec 12; 122(25):4140-9. Han J, Zhang G, Welch EJ, Liang Y, Fu J, Vogel SM, Lowell CA, Du X, Cheresh DA, Malik AB, Li Z. PMID: 24108461.
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    74. Expression of the TEL-Syk fusion protein in hematopoietic stem cells leads to rapidly fatal myelofibrosis in mice. PLoS One. 2013; 8(10):e77542. Graham MT, Abram CL, Hu Y, Lowell CA. PMID: 24116232.
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    75. The multifaceted functions of neutrophils. Annu Rev Pathol. 2014; 9:181-218. Mayadas TN, Cullere X, Lowell CA. PMID: 24050624.
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    76. Neutrophils mediate antibody-induced antitumor effects in mice. Blood. 2013 Oct 31; 122(18):3160-4. Albanesi M, Mancardi DA, Jönsson F, Iannascoli B, Fiette L, Di Santo JP, Lowell CA, Bruhns P. PMID: 23980063.
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    77. Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):E3311-20. Lamagna C, Scapini P, van Ziffle JA, DeFranco AL, Lowell CA. PMID: 23940344.
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    78. Hck contributes to bone homeostasis by controlling the recruitment of osteoclast precursors. FASEB J. 2013 Sep; 27(9):3608-18. Vérollet C, Gallois A, Dacquin R, Lastrucci C, Pandruvada SN, Ortega N, Poincloux R, Behar A, Cougoule C, Lowell C, Al Saati T, Jurdic P, Maridonneau-Parini I. PMID: 23742809.
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    79. CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma. Blood. 2013 Jun 06; 121(23):4740-8. Rubenstein JL, Wong VS, Kadoch C, Gao HX, Barajas R, Chen L, Josephson SA, Scott B, Douglas V, Maiti M, Kaplan LD, Treseler PA, Cha S, Hwang JH, Cinque P, Cyster JG, Lowell C. PMID: 23570798.
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    80. Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice. Immunity. 2013 Mar 21; 38(3):489-501. Abram CL, Roberge GL, Pao LI, Neel BG, Lowell CA. PMID: 23521885.
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    81. Class I phosphoinositide-3-kinases and SRC kinases play a nonredundant role in regulation of adhesion-independent and -dependent neutrophil reactive oxygen species generation. J Immunol. 2013 Apr 01; 190(7):3648-60. Fumagalli L, Campa CC, Germena G, Lowell CA, Hirsch E, Berton G. PMID: 23447687.
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    82. Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization. Dev Cell. 2013 Feb 25; 24(4):372-83. Heit B, Kim H, Cosío G, Castaño D, Collins R, Lowell CA, Kain KC, Trimble WS, Grinstein S. PMID: 23395392.
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    83. Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung. Cell Rep. 2012 Dec 27; 2(6):1762-73. Jhingran A, Mar KB, Kumasaka DK, Knoblaugh SE, Ngo LY, Segal BH, Iwakura Y, Lowell CA, Hamerman JA, Lin X, Hohl TM. PMID: 23200858.
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    84. Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma. Blood. 2013 Jan 31; 121(5):745-51. Rubenstein JL, Li J, Chen L, Advani R, Drappatz J, Gerstner E, Batchelor T, Krouwer H, Hwang J, Auerback G, Kadoch C, Lowell C, Munster P, Cha S, Shuman MA, Damon LE. PMID: 23197589.
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    85. Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement. J Cell Sci. 2012 Nov 15; 125(Pt 22):5535-45. Alenghat FJ, Baca QJ, Rubin NT, Pao LI, Matozaki T, Lowell CA, Golan DE, Neel BG, Swanson KD. PMID: 22976304.
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    86. Dectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived antigens. J Biol Chem. 2012 Oct 05; 287(41):34149-56. Ma J, Becker C, Lowell CA, Underhill DM. PMID: 22902620.
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    87. Distinct and overlapping functional roles of Src family kinases in mouse platelets. J Thromb Haemost. 2012 Aug; 10(8):1631-45. Séverin S, Nash CA, Mori J, Zhao Y, Abram C, Lowell CA, Senis YA, Watson SP. PMID: 22694307.
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    88. Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury. J Exp Med. 2012 Feb 13; 209(2):407-21. Block H, Herter JM, Rossaint J, Stadtmann A, Kliche S, Lowell CA, Zarbock A. PMID: 22291096.
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    89. Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans. Anesth Analg. 2012 Mar; 114(3):511-9. Weiskopf RB, Feiner J, Toy P, Twiford J, Shimabukuro D, Lieberman J, Looney MR, Lowell CA, Gropper MA. PMID: 22262647.
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    90. Establishment of a Novel System for Studying the Syk Function in B Cells. Chembiomolecular Science. 2012 Jan 1; 177-182. Kurosaki KT, Lowell LC. .
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    91. Overview: studying integrins in vivo. Methods Mol Biol. 2012; 757:369-97. Lowell CA, Mayadas TN. PMID: 21909923.
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    92. B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K. Proc Natl Acad Sci U S A. 2012 Jan 03; 109(1):267-72. Ni M, MacFarlane AW, Toft M, Lowell CA, Campbell KS, Hamerman JA. PMID: 22187458.
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    93. Transfusion-related acute lung injury: incidence and risk factors. Blood. 2012 Feb 16; 119(7):1757-67. Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, Hirschler N, Sanchez Rosen R, Matthay MA, TRALI Study Group . PMID: 22117051.
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    94. Genomic and Molecular Properties of Relapsed CNS Lymphoma Using Novel Primary Meningeal Lymphoma Cell Lines and Intracranial Xenografts,. Blood. 2011 Nov 18; 118(21):3477-3477. Gao GH, Anderson AS, Chen CL, Kadoch KC, Hann HB, Lowell LC, Collins CC, Rubenstein RJ. .
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    95. Dynamic Changes in Macrophage Polarization Correlate with Progression and Response in CNS Lymphoma: Insights Into the Transcriptome of Lymphoma-Associated M2 Macrophages,. Blood. 2011 Nov 18; 118(21):3219-3219. Kadoch KC, Wong WV, Chen CL, Bet-Lachin BA, Roy RR, Hyun HW, Behler BC, Lowell LC, Rubenstein RJ. .
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    96. Strain-dependent induction of neutrophil histamine production and cell death by Pseudomonas aeruginosa. J Leukoc Biol. 2012 Feb; 91(2):275-84. Xu X, Zhang H, Song Y, Lynch SV, Lowell CA, Wiener-Kronish JP, Caughey GH. PMID: 22075928.
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    97. Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureus. Immunity. 2011 Nov 23; 35(5):757-69. Zhu JW, Doan K, Park J, Chau AH, Zhang H, Lowell CA, Weiss A. PMID: 22078799.
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    98. Deletion of Syk in neutrophils prevents immune complex arthritis. J Immunol. 2011 Oct 15; 187(8):4319-30. Elliott ER, Van Ziffle JA, Scapini P, Sullivan BM, Locksley RM, Lowell CA. PMID: 21918195.
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    99. B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):E823-32. Scapini P, Lamagna C, Hu Y, Lee K, Tang Q, DeFranco AL, Lowell CA. PMID: 21911371.
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    100. The process of macrophage migration promotes matrix metalloproteinase-independent invasion by tumor cells. J Immunol. 2011 Oct 01; 187(7):3806-14. Guiet R, Van Goethem E, Cougoule C, Balor S, Valette A, Al Saati T, Lowell CA, Le Cabec V, Maridonneau-Parini I. PMID: 21880978.
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    101. Critical role for Syk in responses to vascular injury. Blood. 2011 Nov 03; 118(18):5000-10. Andre P, Morooka T, Sim D, Abe K, Lowell C, Nanda N, Delaney S, Siu G, Yan Y, Hollenbach S, Pandey A, Gao H, Wang Y, Nakajima K, Parikh SA, Shi C, Phillips D, Owen W, Sinha U, Simon DI. PMID: 21881044.
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    102. Differential transformation capacity of Src family kinases during the initiation of prostate cancer. Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16):6579-84. Cai H, Smith DA, Memarzadeh S, Lowell CA, Cooper JA, Witte ON. PMID: 21464326.
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    103. Neutrophils give us a shock. J Clin Invest. 2011 Apr; 121(4):1260-3. Lowell CA. PMID: 21436575.
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    104. Paired immunoglobin-like receptor-B regulates the suppressive function and fate of myeloid-derived suppressor cells. Immunity. 2011 Mar 25; 34(3):385-95. Ma G, Pan PY, Eisenstein S, Divino CM, Lowell CA, Takai T, Chen SH. PMID: 21376641.
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    105. Src-family and Syk kinases in activating and inhibitory pathways in innate immune cells: signaling cross talk. Cold Spring Harb Perspect Biol. 2011 Mar 01; 3(3). Lowell CA. PMID: 21068150.
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    106. IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina. J Immunol. 2011 Feb 15; 186(4):2372-81. Nelson MP, Christmann BS, Werner JL, Metz AE, Trevor JL, Lowell CA, Steele C. PMID: 21220696.
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    107. Pyk2 is required for neutrophil degranulation and host defense responses to bacterial infection. J Immunol. 2011 Feb 01; 186(3):1656-65. Kamen LA, Schlessinger J, Lowell CA. PMID: 21187437.
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    108. Interferon-γ production by neutrophils during bacterial pneumonia in mice. Am J Respir Crit Care Med. 2011 May 15; 183(10):1391-401. Yamada M, Gomez JC, Chugh PE, Lowell CA, Dinauer MC, Dittmer DP, Doerschuk CM. PMID: 21169470.
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    109. SYK Is a Tumor Suppressor In Pre-B Cell Acute Lymphoblastic Leukemia and Not a Therapeutic Target. Blood. 2010 Nov 19; 116(21):4199-4199. Ng NC, Nahar NR, Elliott EE, Lowell LC, Muschen MM. .
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    110. Mechanisms of Pre-B Cell Receptor-Inactivation In Acute Lymphoblastic Leukemia. Blood. 2010 Nov 19; 116(21):147-147. Duy DC, Nowak ND, Klemm KL, Nahar NR, Ng NC, Elliott EE, Hofmann HW, Heisterkamp HN, Lowell LC, Koeffler KP, Muschen MM. .
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    111. The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity. Immunity. 2010 Aug 27; 33(2):181-91. Tavares RM, Turer EE, Liu CL, Advincula R, Scapini P, Rhee L, Barrera J, Lowell CA, Utz PJ, Malynn BA, Ma A. PMID: 20705491.
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    112. Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J Exp Med. 2010 Aug 02; 207(8):1757-73. Scapini P, Hu Y, Chu CL, Migone TS, Defranco AL, Cassatella MA, Lowell CA. PMID: 20624892.
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    113. Interim results of a phase I trial of intraventricular rituximab plus methotrexate in recurrent CNS lymphoma: Macrophage polarization and acquired resistance to therapy. Journal of Clinical Oncology. 2010 May 20; 28(15_suppl):2532-2532. Rubenstein RJ, Kadoch KC, Wong WV, Hyun HW, Lowell LC. .
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    114. An important role of the SRC family kinase Lyn in stimulating platelet granule secretion. J Biol Chem. 2010 Apr 23; 285(17):12559-70. Li Z, Zhang G, Liu J, Stojanovic A, Ruan C, Lowell CA, Du X. PMID: 20189992.
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    115. Management practices and phytoremediation by native grasses. Int J Phytoremediation. 2010 Feb; 12(2):200-14. Nedunuri KV, Lowell C, Meade W, Vonderheide AP, Shann JR. PMID: 20734616.
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    116. c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration. FEBS Lett. 2010 Jan 04; 584(1):15-21. Baruzzi A, Iacobucci I, Soverini S, Lowell CA, Martinelli G, Berton G. PMID: 19903482.
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    117. Macrophage Polarization and Acquired Resistance to Rituximab in CNS Lymphoma. Blood. 2009 Nov 20; 114(22):3749-3749. Kadoch KC, Wong WV, Rambaldo RT, Hyun HW, Lowell LC, Rubenstein RJ. .
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    118. Three-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysis. Blood. 2010 Feb 18; 115(7):1444-52. Cougoule C, Le Cabec V, Poincloux R, Al Saati T, Mège JL, Tabouret G, Lowell CA, Laviolette-Malirat N, Maridonneau-Parini I. PMID: 19897576.
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    119. The expanding roles of ITAM adapters FcRgamma and DAP12 in myeloid cells. Immunol Rev. 2009 Nov; 232(1):42-58. Hamerman JA, Ni M, Killebrew JR, Chu CL, Lowell CA. PMID: 19909355.
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    120. Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest. 2009 Nov; 119(11):3450-61. Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay MA. PMID: 19809160.
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    121. Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection. Blood. 2009 Nov 26; 114(23):4871-82. Van Ziffle JA, Lowell CA. PMID: 19797524.
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    122. Microarray kit analysis of cytokines in blood product units and segments. Transfusion. 2009 Nov; 49(11):2269-75. Weiskopf RB, Yau R, Sanchez R, Lowell C, Toy P. PMID: 19548981.
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    123. Leukocyte adhesion deficiency syndrome: a controversy solved. Immunol Cell Biol. 2009 Aug-Sep; 87(6):440-2. Abram CL, Lowell CA. PMID: 19417769.
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    124. Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model. Clin Cancer Res. 2009 Mar 15; 15(6):1989-97. Kadoch C, Dinca EB, Voicu R, Chen L, Nguyen D, Parikh S, Karrim J, Shuman MA, Lowell CA, Treseler PA, James CD, Rubenstein JL. PMID: 19276270.
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    125. The absence of Hck, Fgr, and Lyn tyrosine kinases augments lung innate immune responses to Pneumocystis murina. Infect Immun. 2009 May; 77(5):1790-7. Nelson MP, Metz AE, Li S, Lowell CA, Steele C. PMID: 19255189.
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    126. Multiple roles of Lyn kinase in myeloid cell signaling and function. Immunol Rev. 2009 Mar; 228(1):23-40. Scapini P, Pereira S, Zhang H, Lowell CA. PMID: 19290919.
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    127. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. Journal of Experimental Medicine. 2009 Feb 16; 206(2):i3-i3. N'Diaye NE, Branda BC, Branda BS, Nevarez NL, Colonna CM, Lowell LC, Hamerman HJ, Seaman SW. .
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    128. Erratum: Corrigendum: Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nature Immunology. 2009 Feb 1; 10(2):223-223. Hamerman HJ, Tchao TN, Lowell LC, Lanier LL. .
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    129. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. J Cell Biol. 2009 Jan 26; 184(2):215-23. N'Diaye EN, Branda CS, Branda SS, Nevarez L, Colonna M, Lowell C, Hamerman JA, Seaman WE. PMID: 19171755.
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    130. Generation of a novel system for studying spleen tyrosine kinase function in macrophages and B cells. J Immunol. 2009 Jan 15; 182(2):988-98. Miller AL, Zhang C, Shokat KM, Lowell CA. PMID: 19124742.
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    131. The ins and outs of leukocyte integrin signaling. Annu Rev Immunol. 2009; 27:339-62. Abram CL, Lowell CA. PMID: 19302044.
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    132. Transmigration of neutrophils across inflamed endothelium is signaled through LFA-1 and Src family kinase. J Immunol. 2008 Dec 15; 181(12):8660-9. Sarantos MR, Zhang H, Schaff UY, Dixit N, Hayenga HN, Lowell CA, Simon SI. PMID: 19050286.
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    133. Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells. Immunity. 2008 Nov 14; 29(5):807-18. Ng G, Sharma K, Ward SM, Desrosiers MD, Stephens LA, Schoel WM, Li T, Lowell CA, Ling CC, Amrein MW, Shi Y. PMID: 18993083.
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    134. PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling. J Exp Med. 2008 Sep 29; 205(10):2339-47. Zarbock A, Abram CL, Hundt M, Altman A, Lowell CA, Ley K. PMID: 18794338.
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    146. TRALI--definition, mechanisms, incidence and clinical relevance. Best Pract Res Clin Anaesthesiol. 2007 Jun; 21(2):183-93. Toy P, Lowell C. PMID: 17650771.
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    149. Cutting Edge: B cell receptor (BCR) cross-talk: the IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to Rottlerin, and depends on Lyn. J Immunol. 2007 Apr 15; 178(8):4726-30. Guo B, Blair D, Chiles TC, Lowell CA, Rothstein TL. PMID: 17404251.
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    153. Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. J Exp Med. 2006 Dec 25; 203(13):2907-17. Xu X, Zhang D, Zhang H, Wolters PJ, Killeen NP, Sullivan BM, Locksley RM, Lowell CA, Caughey GH. PMID: 17158962.
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    168. Increased expression of genes linked to FcepsilonRI Signaling and to cytokine and chemokine production in Lyn-deficient mast cells. J Immunol. 2005 Dec 15; 175(12):7880-8. Hernandez-Hansen V, Bard JD, Tarleton CA, Wilder JA, Lowell CA, Wilson BS, Oliver JM. PMID: 16339523.
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    170. Regulation of K-Cl cotransport by protein phosphatase 1alpha in mouse erythrocytes. Pflugers Arch. 2006 Mar; 451(6):760-8. De Franceschi L, Villa-Moruzzi E, Biondani A, Siciliano A, Brugnara C, Alper SL, Lowell CA, Berton G. PMID: 16283202.
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    172. The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4. Biochem Pharmacol. 2005 Oct 15; 70(8):1231-40. Lee JY, Lowell CA, Lemay DG, Youn HS, Rhee SH, Sohn KH, Jang B, Ye J, Chung JH, Hwang DH. PMID: 16140274.
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    178. Minimum conditions of major histocompatibility complex compatibility and recipient immune compromise required to establish donor white blood cell persistence in a murine transfusion model. Transfusion. 2005 Mar; 45(3):301-14. Lee TH, Wen L, Montalvo L, Esho O, Lowell C, Reed W, Busch M. PMID: 15752147.
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    180. The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization. Exp Cell Res. 2005 Jan 15; 302(2):253-69. Continolo S, Baruzzi A, Majeed M, Caveggion E, Fumagalli L, Lowell CA, Berton G. PMID: 15561106.
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    182. Lyn Kinase Supports Primary Erythroid Progenitor Cell Development. Blood. 2004 Nov 16; 104(11):1622-1622. Karur KV, Vincent VB, Lowell LC, Wojchowski WD. .
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    187. Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury. J Clin Invest. 2004 Jul; 114(1):49-56. Chou WH, Choi DS, Zhang H, Mu D, McMahon T, Kharazia VN, Lowell CA, Ferriero DM, Messing RO. PMID: 15232611.
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    213. Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells. Blood. 2001 Jul 15; 98(2):343-50. O'Laughlin-Bunner B, Radosevic N, Taylor ML, Shivakrupa , DeBerry C, Metcalfe DD, Zhou M, Lowell C, Linnekin D. PMID: 11435302.
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    214. Resting murine neutrophils express functional alpha 4 integrins that signal through Src family kinases. J Immunol. 2001 Mar 15; 166(6):4115-23. Pereira S, Zhou M, Mócsai A, Lowell C. PMID: 11238661.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    215. Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn. Curr Biol. 2001 Jan 09; 11(1):34-8. Yu CC, Yen TS, Lowell CA, DeFranco AL. PMID: 11166177.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    216. Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway. Blood. 2000 Dec 15; 96(13):4246-53. Quek LS, Pasquet JM, Hers I, Cornall R, Knight G, Barnes M, Hibbs ML, Dunn AR, Lowell CA, Watson SP. PMID: 11110698.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    217. Fyn and Lyn phosphorylate the Fc receptor ? chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway. Blood. 2000 Dec 15; 96(13):4246-4253. Quek QL, Pasquet PJ, Hers HI, Cornall CR, Knight KG, Barnes BM, Hibbs HM, Dunn DA, Lowell LC, Watson WS. .
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    218. Evidence of a role for SHP-1 in platelet activation by the collagen receptor glycoprotein VI. J Biol Chem. 2000 Sep 15; 275(37):28526-31. Pasquet JM, Quek L, Pasquet S, Poole A, Matthews JR, Lowell C, Watson SP. PMID: 10871605.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    219. Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation. J Immunol. 2000 Aug 01; 165(3):1210-9. Kawakami Y, Kitaura J, Satterthwaite AB, Kato RM, Asai K, Hartman SE, Maeda-Yamamoto M, Lowell CA, Rawlings DJ, Witte ON, Kawakami T. PMID: 10903718.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    220. CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification. Immunity. 2000 Jul; 13(1):47-57. Fujimoto M, Fujimoto Y, Poe JC, Jansen PJ, Lowell CA, DeFranco AL, Tedder TF. PMID: 10933394.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    221. Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7423-8. Kawakami Y, Kitaura J, Hartman SE, Lowell CA, Siraganian RP, Kawakami T. PMID: 10852954.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    222. A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6687-92. Satterthwaite AB, Willis F, Kanchanastit P, Fruman D, Cantley LC, Helgason CD, Humphries RK, Lowell CA, Simon M, Leitges M, Tarakhovsky A, Tedder TF, Lesche R, Wu H, Witte ON. PMID: 10829070.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    223. Kinase pathways in chemoattractant-induced degranulation of neutrophils: the role of p38 mitogen-activated protein kinase activated by Src family kinases. J Immunol. 2000 Apr 15; 164(8):4321-31. Mócsai A, Jakus Z, Vántus T, Berton G, Lowell CA, Ligeti E. PMID: 10754332.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    224. Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharide-stimulated nitric oxide production in macrophages via interferon-beta. J Leukoc Biol. 2000 Mar; 67(3):405-14. Weinstein SL, Finn AJ, Davé SH, Meng F, Lowell CA, Sanghera JS, DeFranco AL. PMID: 10733102.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    225. Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn. J Exp Med. 2000 Feb 21; 191(4):669-82. Fitzer-Attas CJ, Lowry M, Crowley MT, Finn AJ, Meng F, DeFranco AL, Lowell CA. PMID: 10684859.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    226. Negative regulation of phagocytosis in murine macrophages by the Src kinase family member, Fgr. J Exp Med. 2000 Feb 07; 191(3):515-28. Gresham HD, Dale BM, Potter JW, Chang PW, Vines CM, Lowell CA, Lagenaur CF, Willman CL. PMID: 10662797.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    227. Flow cytometric detection of CD10 (cALLA) on peripheral blood B lymphocytes of neonates. Br J Haematol. 1999 Dec; 107(4):712-5. Brady KA, Atwater SK, Lowell CA. PMID: 10606874.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    228. Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages. J Cell Sci. 1999 Nov; 112 ( Pt 22):4067-78. Suen PW, Ilic D, Caveggion E, Berton G, Damsky CH, Lowell CA. PMID: 10547366.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    229. Integrin signalling in neutrophils and macrophages. Cell Signal. 1999 Sep; 11(9):621-35. Berton G, Lowell CA. PMID: 10530871.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    230. Integrin signal transduction in myeloid leukocytes. J Leukoc Biol. 1999 Mar; 65(3):313-20. Lowell CA, Berton G. PMID: 10080533.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    231. Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck. J Immunol. 1999 Jan 15; 162(2):1120-6. Mócsai A, Ligeti E, Lowell CA, Berton G. PMID: 9916742.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    232. Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways. J Exp Med. 1998 Sep 07; 188(5):833-44. Satterthwaite AB, Lowell CA, Khan WN, Sideras P, Alt FW, Witte ON. PMID: 9730885.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    233. A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration. EMBO J. 1998 Aug 03; 17(15):4391-403. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Meng F, Lowell CA. PMID: 9687507; PMCID: PMC1170772.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    234. Positive and negative roles of the tyrosine kinase Lyn in B cell function. Semin Immunol. 1998 Aug; 10(4):299-307. DeFranco AL, Chan VW, Lowell CA. PMID: 9695186.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    235. The molecular mechanism of B cell activation by toll-like receptor protein RP-105. J Exp Med. 1998 Jul 06; 188(1):93-101. Chan VW, Mecklenbräuker I, Su I, Texido G, Leitges M, Carsetti R, Lowell CA, Rajewsky K, Miyake K, Tarakhovsky A. PMID: 9653087.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    236. Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr. Proc Natl Acad Sci U S A. 1998 Jun 23; 95(13):7580-4. Lowell CA, Berton G. PMID: 9636192.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    237. Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes. Curr Biol. 1998 May 07; 8(10):545-53. Chan VW, Lowell CA, DeFranco AL. PMID: 9601638.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    238. Macrophages kill T9 glioma tumor cells bearing the membrane isoform of macrophage colony stimulating factor through a phagocytosis-dependent pathway. J Immunol. 1998 Jan 01; 160(1):361-8. Jadus MR, Williams CC, Avina MD, Ly M, Kim S, Liu Y, Narasaki R, Lowell CA, Wepsic HT. PMID: 9551992.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    239. Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice. Genes Dev. 1997 Nov 01; 11(21):2835-44. Schwartzberg PL, Xing L, Hoffmann O, Lowell CA, Garrett L, Boyce BF, Varmus HE. PMID: 9353253.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    240. A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages. J Exp Med. 1997 Oct 06; 186(7):1027-39. Crowley MT, Costello PS, Fitzer-Attas CJ, Turner M, Meng F, Lowell C, Tybulewicz VL, DeFranco AL. PMID: 9314552.
      View in: PubMed   Mentions: 134     Fields:    Translation:AnimalsCells
    241. Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity. 1997 Jul; 7(1):69-81. Chan VW, Meng F, Soriano P, DeFranco AL, Lowell CA. PMID: 9252121.
      View in: PubMed   Mentions: 141     Fields:    Translation:AnimalsCells
    242. Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn. J Exp Med. 1997 May 05; 185(9):1661-70. Meng F, Lowell CA. PMID: 9151903.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    243. Deficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport. J Clin Invest. 1997 Jan 15; 99(2):220-7. De Franceschi L, Fumagalli L, Olivieri O, Corrocher R, Lowell CA, Berton G. PMID: 9005990.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    244. Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories. Genes Dev. 1996 Aug 01; 10(15):1845-57. Lowell CA, Soriano P. PMID: 8756343.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    245. Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions. J Cell Biol. 1996 May; 133(4):895-910. Lowell CA, Fumagalli L, Berton G. PMID: 8666673.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    246. Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis. Blood. 1996 Mar 01; 87(5):1780-92. Lowell CA, Niwa M, Soriano P, Varmus HE. PMID: 8634424.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    247. Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis. Blood. 1996 Mar 1; 87(5):1780-1792. Lowell LC, Niwa NM, Soriano SP, Varmus VH. .
      View in: Publisher Site   Mentions:
    248. Neutrophil activation by adhesion: mechanisms and pathophysiological implications. Int J Clin Lab Res. 1996; 26(3):160-77. Berton G, Yan SR, Fumagalli L, Lowell CA. PMID: 8905448.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    249. Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. Genes Dev. 1994 Feb 15; 8(4):387-98. Lowell CA, Soriano P, Varmus HE. PMID: 8125254.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    250. Cancer genes and hematopoiesis. Blood. 1994 Jan 01; 83(1):5-9. Varmus HE, Lowell CA. PMID: 8274752.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    251. Mapping of the Epstein-Barr virus and C3dg binding sites to a common domain on complement receptor type 2. J Exp Med. 1989 Dec 01; 170(6):1931-46. Lowell CA, Klickstein LB, Carter RH, Mitchell JA, Fearon DT, Ahearn JM. PMID: 2479703.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    252. Sucrose-metabolizing enzymes in transport tissues and adjacent sink structures in developing citrus fruit. Plant Physiol. 1989 Aug; 90(4):1394-402. Lowell CA, Tomlinson PT, Koch KE. PMID: 16666942.
      View in: PubMed   Mentions: 32     Fields:    
    253. Fenoprofen-induced immune hemolysis. Difficulties in diagnosis and complications in compatibility testing. Am J Clin Pathol. 1988 Mar; 89(3):410-4. Shirey RS, Morton SJ, Lawton KB, Lowell C, Kickler TS, Ness PM. PMID: 3348176.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    254. Structure of the murine serum amyloid A gene family. Gene conversion. J Biol Chem. 1986 Jun 25; 261(18):8442-52. Lowell CA, Potter DA, Stearman RS, Morrow JF. PMID: 3013853.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    255. Transcriptional regulation of serum amyloid A gene expression. J Biol Chem. 1986 Jun 25; 261(18):8453-61. Lowell CA, Stearman RS, Morrow JF. PMID: 2424896.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    256. The sequence and structure of a new serum amyloid A gene. Nucleic Acids Res. 1986 Jan 24; 14(2):797-809. Stearman RS, Lowell CA, Peltzman CG, Morrow JF. PMID: 3003697.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    257. Regulation of synthesis of amyloid A-related protein. Ann N Y Acad Sci. 1982; 389:106-15. Stearman RS, Lowell CA, Pearson WR, Morrow JF. PMID: 6953913.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    258. Mechanism of mitochondrial DNA replication in mouse L-cells. Replication of unicircular dimer molecules. J Mol Biol. 1981 May 05; 148(1):77-93. Bogenhagen D, Lowell C, Clayton DA. PMID: 7310869.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    259. S1 nuclease-specific nicking of mitochondrial DNA containing displacement loops. Anal Biochem. 1978 Dec; 91(2):521-31. Lowell C, Bogenhagen D, Clayton DA. PMID: 9762139.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    260. Topical anesthetic effectiveness. An old and new product evaluated. N Y J Dent. 1972 Nov; 38(9):549-50. Howitt JW, Lowell C. PMID: 4562117.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    261. Topical anesthetic effectiveness. An old and new product evaluated. N Y State Dent J. 1972 Nov; 38(9):549-50. Howitt JW, Lowell C. PMID: 4578243.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
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