Clifford Lowell, MD, PhD

Title(s)Professor, Laboratory Medicine
SchoolSchool of Medicine
Address513 Parnassus Avenue, MSB, #1210
San Francisco CA 94143
Phone415-476-2963
PronounsHe/Him/His
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    Other Positions
    Title(s)Chair, Laboratory Medicine


    Collapse Biography 
    Collapse education and training
    Stanford UniversityBS1979Biology
    Johns Hopkins UniversityMD - PhD1986School of Medicine
    Johns Hopkins HospitalOsler Medical House Officier1989Medicine
    University of California, San FranciscoClinical Fellowship 1992Oncology
    University of California, San FranciscoPost-Doctoral Research Fellowship1995Laboratory: Harold Varmus
    University of California, San Francisco2022Diversity, Equity, Inclusion Champion Training
    Collapse awards and honors
    LLS2001Leukemia/Lymphoma Society Scholar
    FASEB2009Elected FASEB conference organizer
    Universite du Quebec2014Elected Advisory Board Neutrophil Immunity
    UCSF2015Distinguished Professorship
    AAP2021Elected American Association of Physicians

    Collapse Overview 
    Collapse overview
    The Lowell laboratory studies tyrosine kinase and phosphatase based signal transduction in innate immune cells. Our general approach involves examination of innate immune function in knockout mice lacking various members of the Src-family or Syk family of tyrosine kinases. Many of these studies also involve use of mice lacking these kinases in specific hematopoietic lineages, such as neutrophils, macrophages or DCs, generated through Cre/Lox technology. We have also used this approach to study other tyrosine kinases (Pyk2/Fak) and intracellular signaling molecules (WASp, STIM1, STIM2) in innate immune cells. Our major findings have illuminated the function of Src-family and Syk kinases in leukocyte integrin signaling – loss of these kinases results in significant defects in inflammatory and host defense functions mediated by integrins. We have found that leukocyte integrin signaling utilizes the same intracellular pathways initiated by classical immunoreceptors (such as FcγRs) by co-opting ITAM-containing adapter proteins. We have also demonstrated the important ways these kinases regulate innate immune cells in the setting of autoimmune and inflammatory diseases, using the Lyn kinase-deficient model. Ongoing studies also involve examination of cytoplasmic tyrosine phosphatases (mainly SHP1) in the counter regulation tyrosine kinases, especially in the setting of hematopoietic malignancy and inflammatory disease. Recent publications highlight the role of SHP1, as a negative regulator of anti-tumor immunity, as well as the role of integrin signaling adapter protein SKAP2 in human autoimmune disease, in particular type 1 diabetes. Publications total = 228; h-index 97.

    Collapse Research 
    Collapse research activities and funding
    Regulation of Innate Immune Signaling by Lyn Kinase
    NIH R01AI113272Feb 1, 2015 - Jan 31, 2021
    Role: Principal Investigator
    Signal Transduction in the Immune System-FASEB Summer Conference
    NIH R13AI084313Jun 21, 2009 - Jun 29, 2009
    Role: Principal Investigator
    Innate immune regulation of inflammation and adaptive immunity
    NIH P01AI078869Jul 15, 2008 - Jun 30, 2014
    Role: Co-Investigator
    FASEB Summer Conference on Signal Transduction in the Immune System
    NIH R13AI074219Jun 1, 2007 - May 31, 2008
    Role: Principal Investigator
    Transfusion and Lung Injury
    NIH P50HL081027Sep 30, 2005 - Aug 31, 2011
    Role: Co-Investigator
    Mechanisms of Neutrophil Activation
    NIH R01AI065495Jul 1, 2005 - Jan 31, 2019
    Role: Principal Investigator
    Proximal Signaling Events in Leukocyte Integrin Function
    NIH R03TW006831Aug 15, 2004 - Jul 31, 2008
    Role: Principal Investigator
    Signaling by Cytoplasmic Tyrosine Kinases in Leukocytes
    NIH R01DK058066Jul 1, 2001 - Jun 30, 2006
    Role: Principal Investigator
    Signaling by Cytoplasmic Tyrosine Kinases in Leukocytes
    NIH R01AI068150Aug 1, 2000 - Jan 31, 2018
    Role: Principal Investigator
    TRANSFUSION BIOLOGY AND MEDICINE
    NIH P50HL054476Feb 1, 1996 - Dec 31, 2006
    Role: Co-Investigator
    MURINE MODELS TO INVESTIGATE THE HEMATOLOGIC SYSTEM
    NIH P01DK050267Aug 15, 1995 - Jul 31, 2001
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. THE TOLL-LIKE RECEPTOR 7/8 PATHWAY HAS PROGNOSTIC SIGNIFICANCE AND IS A THERAPEUTIC TARGET IN CNS LYMPHOMAS. Hematological Oncology. 2025 Jun 16; 43(S3). Geng GH, Randall RM, Ballapuram BA, Chen CL, Yung YC, Lu LM, Lowell LC, Rubenstein RJ. .
      View in: Publisher Site   Mentions:
    2. THERAPY-DRIVEN EVOLUTION AND INTRATUMORAL GENETIC HETEROGENEITY IN CNS LYMPHOMAS. Hematological Oncology. 2025 Jun 16; 43(S3). Solomon SD, Geng GH, Randall RM, Sobel SR, Cleveland CJ, Ballapuram BA, Chen CL, Lu LM, Cha CS, Lowell LC, Devine DW, Rubenstein RJ. .
      View in: Publisher Site   Mentions:
    3. Neutrophil-specific Shp1 loss results in lethal pulmonary hemorrhage in mouse models of acute lung injury. J Clin Invest. 2024 Oct 01; 134(24). Moussavi-Harami SF, Cleary SJ, Magnen M, Seo Y, Conrad C, English BC, Qiu L, Wang KM, Abram CL, Lowell CA, Looney MR. PMID: 39352872; PMCID: PMC11645157.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    4. TLR Engagement Induces an Alternate Pathway for BCR Signaling that Results in PKCδ Phosphorylation. J Immunol. 2024 Jun 01; 212(11):1639-1646. Khan N, Hu Y, Lowell CA, Rothstein TL. PMID: 38629913.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Loss of neutrophil Shp1 produces hemorrhagic and lethal acute lung injury. bioRxiv. 2024 May 28. Moussavi-Harami SF, Cleary SJ, Magnen M, Seo Y, Conrad C, English BC, Qiu L, Wang KM, Abram CL, Lowell CA, Looney MR. PMID: 38854059; PMCID: PMC11160570.
      View in: PubMed   Mentions:
    6. Expression of Concern: Pyk2 Is Required for Neutrophil Degranulation and Host Defense Responses to Bacterial Infection. J Immunol. 2024 05 15; 212(10):1604. Kamen LA, Schlessinger J, Lowell CA. PMID: 38709995.
      View in: PubMed   Mentions:    Fields:    
    7. Transcriptomic Analyses of B Cells Infected In Vitro with Transmitted/Founder HIV-1 of R5 Phenotype (HIV-R5) Reveal Downregulation of IGLL1 Gene in Persistent Infection. The Journal of Immunology. 2024 May 1; 212(1_Supplement):0897_7958-0897_7958. Vyas VG, Bozzini BR, Nix NM, Sanchez SC, Santos SY, Vashishtha VA, Wiita WA, Chiu CC, Lowell LC. .
      View in: Publisher Site   Mentions:
    8. Insights from CTTACC: immune system reset by cellular therapies for chronic illness after trauma, infection, and burn. Cytotherapy. 2024 Jul; 26(7):714-718. Bertram K, Cox C, Alam H, Lowell C, Cuschieri J, Parekkadan B, Pati S. PMID: 38506768.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. Validation of a murine proteome-wide phage display library for identification of autoantibody specificities. JCI Insight. 2023 12 08; 8(23). Rackaityte E, Proekt I, Miller HS, Ramesh A, Brooks JF, Kung AF, Mandel-Brehm C, Yu D, Zamecnik CR, Bair R, Vazquez SE, Sunshine S, Abram CL, Lowell CA, Rizzuto G, Wilson MR, Zikherman J, Anderson MS, DeRisi JL. PMID: 37934865; PMCID: PMC10795829.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    10. Thrombopoietin levels in sepsis and septic shock - a systematic review and meta-analysis. Clin Chem Lab Med. 2024 Apr 25; 62(5):999-1010. Liu C, Görlich D, Lowell CA, Italiano JE, Rossaint J, Bender M, Zarbock A, Margraf A. PMID: 38037809.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Myeloid Src-family kinases are critical for neutrophil-mediated autoinflammation in gout and motheaten models. J Exp Med. 2023 07 03; 220(7). Futosi K, Németh T, Horváth ÁI, Abram CL, Tusnády S, Lowell CA, Helyes Z, Mócsai A. PMID: 37074415; PMCID: PMC10120404.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    12. Validation of a murine proteome-wide phage display library for the identification of autoantibody specificities. bioRxiv. 2023 Apr 07. Rackaityte E, Proekt I, Miller HS, Ramesh A, Brooks JF, Kung AF, Mandel-Brehm C, Yu D, Zamecnik C, Bair R, Vazquez SE, Sunshine S, Abram CL, Lowell CA, Rizzuto G, Wilson MR, Zikherman J, Anderson MS, DeRisi JL. PMID: 37066405; PMCID: PMC10104109.
      View in: PubMed   Mentions:
    13. NEF-Induced HIV-Associated Nephropathy Through HCK/LYN Tyrosine Kinases. Am J Pathol. 2023 06; 193(6):702-724. Hu C, Priceputu E, Cool M, Chrobak P, Bouchard N, Forestier C, Lowell CA, Bénichou S, Hanna Z, Royal V, Jolicoeur P. PMID: 36868467; PMCID: PMC10284032.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    14. Neutrophils inhibit γδ T cell functions in the imiquimod-induced mouse model of psoriasis. Front Immunol. 2022; 13:1049079. Costa S, Bevilacqua D, Caveggion E, Gasperini S, Zenaro E, Pettinella F, Donini M, Dusi S, Constantin G, Lonardi S, Vermi W, De Sanctis F, Ugel S, Cestari T, Abram CL, Lowell CA, Rodegher P, Tagliaro F, Girolomoni G, Cassatella MA, Scapini P. PMID: 36466913; PMCID: PMC9709482.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    15. Glutamine prevents acute kidney injury by modulating oxidative stress and apoptosis in tubular epithelial cells. JCI Insight. 2022 11 08; 7(21). Thomas K, Zondler L, Ludwig N, Kardell M, Lüneburg C, Henke K, Mersmann S, Margraf A, Spieker T, Tekath T, Velic A, Holtmeier R, Hermann J, Jankowski V, Meersch M, Vestweber D, Westphal M, Roth J, Schäfers MA, Kellum JA, Lowell CA, Rossaint J, Zarbock A. PMID: 36107633; PMCID: PMC9675453.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    16. Inhibition of HCK in myeloid cells restricts pancreatic tumor growth and metastasis. Cell Rep. 2022 10 11; 41(2):111479. Poh AR, O'Brien M, Chisanga D, He H, Baloyan D, Traichel J, Dijkstra C, Chopin M, Nutt S, Whitehead L, Boon L, Parkin A, Lowell C, Pajic M, Shi W, Nikfarjam M, Ernst M. PMID: 36223746; PMCID: PMC11299506.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    17. Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy. Sci Adv. 2022 Jun 24; 8(25):eabl7882. Poh AR, Love CG, Chisanga D, Steer JH, Baloyan D, Chopin M, Nutt S, Rautela J, Huntington ND, Etemadi N, O'Brien M, O'Keefe R, Ellies LG, Macri C, Mintern JD, Whitehead L, Gangadhara G, Boon L, Chand AL, Lowell CA, Shi W, Pixley FJ, Ernst M. PMID: 35731867; PMCID: PMC9216510.
      View in: PubMed   Mentions: 10     Fields:    
    18. Hyperuricemia reduces neutrophil function. Blood. 2022 06 09; 139(23):3354-3356. Lowell CA. PMID: 35679075.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    19. Autoantigen specific T-cell receptor induces organ-specific autoimmunity by escaping T cell negative selection. The Journal of Immunology. 2022 May 1; 208(1_Supplement):104.02-104.02. Yin YM, Smith SJ, Chou CM, Chan CJ, Hu HY, Lowell LC, Gould GD, Anderson AM, DeFranco DA. .
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    20. Development of uveitis in a mouse model of spontaneous autoimmunity correlates with frequency of autoantigen-specific regulatory T cells. The Journal of Immunology. 2022 May 1; 208(1_Supplement):44.07-44.07. Yin YM, Hiam HK, Proekt PI, Chan CJ, Hu HY, Lowell LC, Gould GD, Spitzer SM, Anderson AM, DeFranco DA. .
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    21. A dominant function of LynB kinase in preventing autoimmunity. Sci Adv. 2022 Apr 22; 8(16):eabj5227. Brian BF, Sauer ML, Greene JT, Senevirathne SE, Lindstedt AJ, Funk OL, Ruis BL, Ramirez LA, Auger JL, Swanson WL, Nunez MG, Moriarity BS, Lowell CA, Binstadt BA, Freedman TS. PMID: 35452291; PMCID: PMC9032976.
      View in: PubMed   Mentions: 3     Fields:    
    22. Neutrophils in acute inflammation: current concepts and translational implications. Blood. 2022 04 07; 139(14):2130-2144. Margraf A, Lowell CA, Zarbock A. PMID: 34624098; PMCID: PMC9728535.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    23. Spleen tyrosine kinase facilitates neutrophil activation and worsens long-term neurologic deficits after spinal cord injury. J Neuroinflammation. 2021 Dec 24; 18(1):302. McCreedy DA, Abram CL, Hu Y, Min SW, Platt ME, Kirchhoff MA, Reid SK, Jalufka FL, Lowell CA. PMID: 34952603; PMCID: PMC8705173.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    24. Regulation of CNS Lymphoma Progression By the Myeloid Microenvironment. Blood. 2021 Nov 5; 138(Supplement 1):448-448. Gao GH, Fraser FE, Merlini MM, Geng GH, Chen CL, Lu LM, Moshfegh MY, Cleveland CJ, Ryu RJ, Sharma SJ, Solomon SD, Akassoglou AK, Lowell LC, Rubenstein RJ. .
      View in: Publisher Site   Mentions:
    25. Signal Integration by Translocation and Phosphorylation of PKCδ in the B Cell Alternate Pathway. J Immunol. 2021 11 01; 207(9):2288-2296. Khan N, Hu Y, Lowell CA, Rothstein TL. PMID: 34588218; PMCID: PMC8638162.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    26. HIV-1 Nef Induces Hck/Lyn-Dependent Expansion of Myeloid-Derived Suppressor Cells Associated with Elevated Interleukin-17/G-CSF Levels. J Virol. 2021 08 10; 95(17):e0047121. Priceputu E, Cool M, Bouchard N, Caceres-Cortes JR, Lowell CA, Hanna Z, Jolicoeur P. PMID: 34106001; PMCID: PMC8354241.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    27. Diabetes With Multiple Autoimmune and Inflammatory Conditions Linked to an Activating SKAP2 Mutation. Diabetes Care. 2021 08; 44(8):1816-1825. Rutsch N, Chamberlain CE, Dixon W, Spector L, Letourneau-Freiberg LR, Lwin WW, Philipson LH, Zarbock A, Saintus K, Wang J, German MS, Anderson MS, Lowell CA. PMID: 34172489; PMCID: PMC8385470.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    28. 1126-P: Activating SKAP2 Mutation Linked to Diabetes with Multiple Autoimmune and Inflammatory Conditions. Diabetes. 2021 Jun 21; 70(Supplement 1):1126-p. CHAMBERLAIN CC, RUTSCH RN, DIXON DW, LETOURNEAU-FREIBERG LL, PHILIPSON PL, GERMAN GM, ANDERSON AM, LOWELL LC. .
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    29. Neutrophil-specific deletion of Syk results in recruitment-independent stabilization of the barrier and a long-term improvement in cognitive function after traumatic injury to the developing brain. Neurobiol Dis. 2021 09; 157:105430. Trivedi A, Tercovich KG, Casbon AJ, Raber J, Lowell C, Noble-Haeusslein LJ. PMID: 34153467; PMCID: PMC11302380.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    30. Inhibitory affinity modulation of FcγRIIA ligand binding by glycosphingolipids by inside-out signaling. Cell Rep. 2021 05 18; 35(7):109142. Okubo K, Brenner MD, Cullere X, Saggu G, Patchen ML, Bose N, Mihori S, Yuan Z, Lowell CA, Zhu C, Mayadas TN. PMID: 34010642; PMCID: PMC8218468.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    31. A CD22-Shp1 phosphatase axis controls integrin ß 7 display and B cell function in mucosal immunity. The FASEB Journal. 2021 May 14; 35(S1). Ballet BR, Brennan BM, Brandl BC, Feng FN, Berri BJ, Cheng CJ, Ocón OB, Alborzian Deh Sheikh AA, Marki MA, Bi BY, Abram AC, Lowell LC, Tsubata TT, Greenberg GH, Macauley MM, Ley LK, Nitschke NL, Butcher BE. .
      View in: Publisher Site   Mentions:
    32. Activation of Lyn kinase and translocation of its PKCd target regulate phosphorylation in the IL-4-induced alternate pathway for BCR signaling. The Journal of Immunology. 2021 May 1; 206(1_Supplement):106.05-106.05. Khan KN, Hu HY, Lowell LC, Rothstein RT. .
      View in: Publisher Site   Mentions:
    33. T-cell receptor repertoire of mice with organ-specific autoimmunity resulting from a partial defect in T cell negative selection and dendritic cell enhancement. The Journal of Immunology. 2021 May 1; 206(1_Supplement):51.06-51.06. Yin YM, Smith SJ, Chou CM, Chan CJ, Hu HY, Lowell LC, Gould GD, Anderson AM, DeFranco DA. .
      View in: Publisher Site   Mentions:
    34. Correlation of autoantigen-specific Treg frequency with development of spontaneous organ-specific autoimmunity in a mouse model of uveitis. The Journal of Immunology. 2021 May 1; 206(1_Supplement):51.05-51.05. Yin YM, Hiam HK, Proekt PI, Chan CJ, Hu HY, Lowell LC, Gould GD, Anderson AM, DeFranco DA. .
      View in: Publisher Site   Mentions:
    35. A CD22-Shp1 phosphatase axis controls integrin β7 display and B cell function in mucosal immunity. Nat Immunol. 2021 03; 22(3):381-390. Ballet R, Brennan M, Brandl C, Feng N, Berri J, Cheng J, Ocón B, Alborzian Deh Sheikh A, Marki A, Bi Y, Abram CL, Lowell CA, Tsubata T, Greenberg HB, Macauley MS, Ley K, Nitschke L, Butcher EC. PMID: 33589816; PMCID: PMC7116842.
      View in: PubMed   Mentions: 8     Fields:    
    36. A neutrophil subset defined by intracellular olfactomedin 4 is associated with mortality in sepsis. Am J Physiol Lung Cell Mol Physiol. 2021 05 01; 320(5):L892-L902. Kangelaris KN, Clemens R, Fang X, Jauregui A, Liu T, Vessel K, Deiss T, Sinha P, Leligdowicz A, Liu KD, Zhuo H, Alder MN, Wong HR, Calfee CS, Lowell C, Matthay MA. PMID: 33355521; PMCID: PMC8174834.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCellsCTClinical Trials
    37. Complement activation on endothelium initiates antibody-mediated acute lung injury. J Clin Invest. 2020 11 02; 130(11):5909-5923. Cleary SJ, Kwaan N, Tian JJ, Calabrese DR, Mallavia B, Magnen M, Greenland JR, Urisman A, Singer JP, Hays SR, Kukreja J, Hay AM, Howie HL, Toy P, Lowell CA, Morrell CN, Zimring JC, Looney MR. PMID: 32730229; PMCID: PMC7598054.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    38. Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity. Front Immunol. 2020; 11:576310. Myers DR, Abram CL, Wildes D, Belwafa A, Welsh AMN, Schulze CJ, Choy TJ, Nguyen T, Omaque N, Hu Y, Singh M, Hansen R, Goldsmith MA, Quintana E, Smith JAM, Lowell CA. PMID: 33133093; PMCID: PMC7550718.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    39. ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defense. Proc Natl Acad Sci U S A. 2020 09 29; 117(39):24403-24414. Grimes D, Johnson R, Pashos M, Cummings C, Kang C, Sampedro GR, Tycksen E, McBride HJ, Sah R, Lowell CA, Clemens RA. PMID: 32929002; PMCID: PMC7533673.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    40. The Ubiquitin-Modifying Enzyme A20 Terminates C-Type Lectin Receptor Signals and Is a Suppressor of Host Defense against Systemic Fungal Infection. Infect Immun. 2020 08 19; 88(9). Liang J, Zhang JJ, Huang HI, Kanayama M, Youssef N, Jin YJ, Reyes EY, Abram CL, Yang S, Lowell CA, Wang D, Shao L, Shinohara ML, Zhang JY, Hammer GE. PMID: 32540868; PMCID: PMC7440764.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    41. Inhibition of the SRC Kinase HCK Impairs STAT3-Dependent Gastric Tumor Growth in Mice. Cancer Immunol Res. 2020 04; 8(4):428-435. Poh AR, Dwyer AR, Eissmann MF, Chand AL, Baloyan D, Boon L, Murrey MW, Whitehead L, O'Brien M, Lowell CA, Putoczki TL, Pixley FJ, O'Donoghue RJJ, Ernst M. PMID: 31992566; PMCID: PMC8064588.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    42. Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils. J Clin Invest. 2020 01 02; 130(1):389-403. Mahiddine K, Blaisdell A, Ma S, Créquer-Grandhomme A, Lowell CA, Erlebacher A. PMID: 31600172; PMCID: PMC6934192.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    43. Src family kinase-mediated vesicle trafficking is critical for neutrophil basement membrane penetration. Haematologica. 2020 07; 105(7):1845-1856. Rohwedder I, Kurz ARM, Pruenster M, Immler R, Pick R, Eggersmann T, Klapproth S, Johnson JL, Alsina SM, Lowell CA, Mócsai A, Catz SD, Sperandio M. PMID: 31699792; PMCID: PMC7327629.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    44. L-selectin shedding affects bacterial clearance in the lung: a new regulatory pathway for integrin outside-in signaling. Blood. 2019 10 24; 134(17):1445-1457. Cappenberg A, Margraf A, Thomas K, Bardel B, McCreedy DA, Van Marck V, Mellmann A, Lowell CA, Zarbock A. PMID: 31366620; PMCID: PMC6839956.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    45. CARD9 mediates dendritic cell-induced development of Lyn deficiency-associated autoimmune and inflammatory diseases. Sci Signal. 2019 10 08; 12(602). Ma J, Abram CL, Hu Y, Lowell CA. PMID: 31594855; PMCID: PMC7546115.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    46. CRAC channel regulation of innate immune cells in health and disease. Cell Calcium. 2019 03; 78:56-65. Clemens RA, Lowell CA. PMID: 30641250; PMCID: PMC8055042.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    47. Early Targeting of L-Selectin on Leukocytes Promotes Recovery after Spinal Cord Injury, Implicating Novel Mechanisms of Pathogenesis. eNeuro. 2018 Jul-Aug; 5(4). McCreedy DA, Lee S, Sontag CJ, Weinstein P, Olivas AD, Martinez AF, Fandel TM, Trivedi A, Lowell CA, Rosen SD, Noble-Haeusslein LJ. PMID: 30225356; PMCID: PMC6140118.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    48. Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma. Blood Adv. 2018 07 10; 2(13):1595-1607. Rubenstein JL, Geng H, Fraser EJ, Formaker P, Chen L, Sharma J, Killea P, Choi K, Ventura J, Kurhanewicz J, Lowell C, Hwang J, Treseler P, Sneed PK, Li J, Wang X, Chen N, Gangoiti J, Munster PN, Damato B. PMID: 29986852; PMCID: PMC6039666.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCTClinical Trials
    49. PRN473, an inhibitor of Bruton's tyrosine kinase, inhibits neutrophil recruitment via inhibition of macrophage antigen-1 signalling. Br J Pharmacol. 2018 02; 175(3):429-439. Herter JM, Margraf A, Volmering S, Correia BE, Bradshaw JM, Bisconte A, Hill RJ, Langrish CL, Lowell CA, Zarbock A. PMID: 29130484; PMCID: PMC5773957.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    50. Neutrophils: Their Role in Innate and Adaptive Immunity 2017. J Immunol Res. 2017; 2017:9748345. Rosales C, Lowell CA, Schnoor M, Uribe-Querol E. PMID: 29238732; PMCID: PMC5697120.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    51. B cell autoimmunity at the extremes. Nat Immunol. 2017 09 19; 18(10):1065-1066. Zikherman J, Lowell CA. PMID: 28926534; PMCID: PMC6334840.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    52. Efficiency and Specificity of Gene Deletion in Lung Epithelial Doxycycline-Inducible Cre Mice. Am J Respir Cell Mol Biol. 2017 08; 57(2):248-257. Sinha M, Lowell CA. PMID: 28287822; PMCID: PMC5576580.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    53. STIM1 and STIM2 cooperatively regulate mouse neutrophil store-operated calcium entry and cytokine production. Blood. 2017 09 28; 130(13):1565-1577. Clemens RA, Chong J, Grimes D, Hu Y, Lowell CA. PMID: 28724541; PMCID: PMC5620414.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
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    57. SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin. Nature. 2017 04 27; 544(7651):493-497. Chen J, Zhong MC, Guo H, Davidson D, Mishel S, Lu Y, Rhee I, Pérez-Quintero LA, Zhang S, Cruz-Munoz ME, Wu N, Vinh DC, Sinha M, Calderon V, Lowell CA, Danska JS, Veillette A. PMID: 28424516; PMCID: PMC5565268.
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    58. Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression. Cancer Cell. 2017 04 10; 31(4):563-575.e5. Poh AR, Love CG, Masson F, Preaudet A, Tsui C, Whitehead L, Monard S, Khakham Y, Burstroem L, Lessene G, Sieber O, Lowell C, Putoczki TL, O'Donoghue RJJ, Ernst M. PMID: 28399411; PMCID: PMC5479329.
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    60. Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9. PLoS One. 2016; 11(12):e0167693. Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM, DeFranco AL. PMID: 27977701; PMCID: PMC5157987.
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    61. Targeting NF-KB Activation in Novel Intracranial Models of CNS Lymphoma. Blood. 2016 Dec 2; 128(22):777-777. Geng GH, Gao GH, Kadoch KC, Lu LM, Chen CL, Anjum AR, Drew DL, Degorce DS, Dillman DK, Mayo MM, Anderson AS, Collins CC, Lowell LC, Rubenstein RJ. .
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    65. Downregulation of the Syk Signaling Pathway in Intestinal Dendritic Cells Is Sufficient To Induce Dendritic Cells That Inhibit Colitis. J Immunol. 2016 10 01; 197(7):2948-57. Hang L, Blum AM, Kumar S, Urban JF, Mitreva M, Geary TG, Jardim A, Stevenson MM, Lowell CA, Weinstock JV. PMID: 27559049; PMCID: PMC5026942.
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    66. MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase. PLoS Pathog. 2016 08; 12(8):e1005787. Wang H, Li M, Hung CY, Sinha M, Lee LM, Wiesner DL, LeBert V, Lerksuthirat T, Galles K, Suresh M, DeFranco AL, Lowell CA, Klein BS, Wüthrich M. PMID: 27542117; PMCID: PMC4991787.
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    67. Immune Defense Protein Expression in Highly Purified Mouse Lung Epithelial Cells. Am J Respir Cell Mol Biol. 2016 06; 54(6):802-13. Sinha M, Lowell CA. PMID: 26574781; PMCID: PMC4942217.
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    68. Triggering of organ-specific autoimmunity through synergy of defects in key tolerance checkpoints. The Journal of Immunology. 2016 May 1; 196(1_Supplement):117.1-117.1. Proekt PI, Miller MC, Jeanne JM, Fasano FK, Lowell LC, Gould GD, Anderson AM, DeFranco DA. .
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    70. Neutrophils in animal models of autoimmune disease. Semin Immunol. 2016 04; 28(2):174-86. Németh T, Mócsai A, Lowell CA. PMID: 27067180; PMCID: PMC4867286.
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    74. The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation. Immunity. 2016 Jan 19; 44(1):73-87. Volmering S, Block H, Boras M, Lowell CA, Zarbock A. PMID: 26777396; PMCID: PMC5030078.
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    75. Integrins: Regulation of Adhesion and Downstream Signaling. Encyclopedia of Immunobiology. 2016 Jan 1; 72-82. Lowell LC. .
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    78. Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses. Immunity. 2015 Oct 20; 43(4):764-75. Yi T, Li J, Chen H, Wu J, An J, Xu Y, Hu Y, Lowell CA, Cyster JG. PMID: 26453377; PMCID: PMC4618158.
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    80. Abstract 2075: Signaling thresholds and negative B cell selection in acute lymphoblastic leukemia. Molecular and Cellular Biology. 2015 Aug 1; 2075-2075. Chen CZ, Shojaee SS, Buchner BM, Geng GH, Lee LJ, Klemm KL, Park PE, Tan TY, Satterthwaite SA, Paietta PE, Hunger HS, Loh LM, Jung JJ, Coligan CJ, Bolland BS, Mak MT, Limnander LA, Jumaa JH, Reth RM, Weiss WA, Lowell LC, Müschen MM. .
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    93. Actin cytoskeleton reorganization by Syk regulates Fcγ receptor responsiveness by increasing its lateral mobility and clustering. Dev Cell. 2014 Jun 09; 29(5):534-546. Jaumouillé V, Farkash Y, Jaqaman K, Das R, Lowell CA, Grinstein S. PMID: 24914558; PMCID: PMC4083245.
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    95. ROS-triggered phosphorylation of complex II by Fgr kinase regulates cellular adaptation to fuel use. Cell Metab. 2014 Jun 03; 19(6):1020-33. Acín-Pérez R, Carrascoso I, Baixauli F, Roche-Molina M, Latorre-Pellicer A, Fernández-Silva P, Mittelbrunn M, Sanchez-Madrid F, Pérez-Martos A, Lowell CA, Manfredi G, Enríquez JA. PMID: 24856931; PMCID: PMC4274740.
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    96. Molecular editing of cellular responses by the high-affinity receptor for IgE. Science. 2014 Feb 28; 343(6174):1021-5. Suzuki R, Leach S, Liu W, Ralston E, Scheffel J, Zhang W, Lowell CA, Rivera J. PMID: 24505132; PMCID: PMC4188507.
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    98. Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice. J Immunol. 2014 Feb 01; 192(3):875-85. Hua Z, Gross AJ, Lamagna C, Ramos-Hernández N, Scapini P, Ji M, Shao H, Lowell CA, Hou B, DeFranco AL. PMID: 24379120; PMCID: PMC4101002.
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    120. Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans. Anesth Analg. 2012 Mar; 114(3):511-9. Weiskopf RB, Feiner J, Toy P, Twiford J, Shimabukuro D, Lieberman J, Looney MR, Lowell CA, Gropper MA. PMID: 22262647; PMCID: PMC3927839.
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    121. Overview: studying integrins in vivo. Methods Mol Biol. 2012; 757:369-97. Lowell CA, Mayadas TN. PMID: 21909923; PMCID: PMC3248401.
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    122. Establishment of a Novel System for Studying the Syk Function in B Cells. Chembiomolecular Science. 2012 Jan 1; 177-182. Kurosaki KT, Lowell LC. .
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    123. B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K. Proc Natl Acad Sci U S A. 2012 Jan 03; 109(1):267-72. Ni M, MacFarlane AW, Toft M, Lowell CA, Campbell KS, Hamerman JA. PMID: 22187458; PMCID: PMC3252908.
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    124. Transfusion-related acute lung injury: incidence and risk factors. Blood. 2012 Feb 16; 119(7):1757-67. Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, Hirschler N, Sanchez Rosen R, Matthay MA, TRALI Study Group. PMID: 22117051; PMCID: PMC3286351.
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    125. Genomic and Molecular Properties of Relapsed CNS Lymphoma Using Novel Primary Meningeal Lymphoma Cell Lines and Intracranial Xenografts,. Blood. 2011 Nov 18; 118(21):3477-3477. Gao GH, Anderson AS, Chen CL, Kadoch KC, Hann HB, Lowell LC, Collins CC, Rubenstein RJ. .
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    126. Dynamic Changes in Macrophage Polarization Correlate with Progression and Response in CNS Lymphoma: Insights Into the Transcriptome of Lymphoma-Associated M2 Macrophages,. Blood. 2011 Nov 18; 118(21):3219-3219. Kadoch KC, Wong WV, Chen CL, Bet-Lachin BA, Roy RR, Hyun HW, Behler BC, Lowell LC, Rubenstein RJ. .
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    127. Strain-dependent induction of neutrophil histamine production and cell death by Pseudomonas aeruginosa. J Leukoc Biol. 2012 Feb; 91(2):275-84. Xu X, Zhang H, Song Y, Lynch SV, Lowell CA, Wiener-Kronish JP, Caughey GH. PMID: 22075928; PMCID: PMC3290427.
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    128. Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureus. Immunity. 2011 Nov 23; 35(5):757-69. Zhu JW, Doan K, Park J, Chau AH, Zhang H, Lowell CA, Weiss A. PMID: 22078799; PMCID: PMC3245876.
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    129. Deletion of Syk in neutrophils prevents immune complex arthritis. J Immunol. 2011 Oct 15; 187(8):4319-30. Elliott ER, Van Ziffle JA, Scapini P, Sullivan BM, Locksley RM, Lowell CA. PMID: 21918195; PMCID: PMC3186826.
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    130. B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):E823-32. Scapini P, Lamagna C, Hu Y, Lee K, Tang Q, DeFranco AL, Lowell CA. PMID: 21911371; PMCID: PMC3193193.
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    131. Critical role for Syk in responses to vascular injury. Blood. 2011 Nov 03; 118(18):5000-10. Andre P, Morooka T, Sim D, Abe K, Lowell C, Nanda N, Delaney S, Siu G, Yan Y, Hollenbach S, Pandey A, Gao H, Wang Y, Nakajima K, Parikh SA, Shi C, Phillips D, Owen W, Sinha U, Simon DI. PMID: 21881044; PMCID: PMC3208305.
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    132. The process of macrophage migration promotes matrix metalloproteinase-independent invasion by tumor cells. J Immunol. 2011 Oct 01; 187(7):3806-14. Guiet R, Van Goethem E, Cougoule C, Balor S, Valette A, Al Saati T, Lowell CA, Le Cabec V, Maridonneau-Parini I. PMID: 21880978; PMCID: PMC4276309.
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    133. Differential transformation capacity of Src family kinases during the initiation of prostate cancer. Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16):6579-84. Cai H, Smith DA, Memarzadeh S, Lowell CA, Cooper JA, Witte ON. PMID: 21464326; PMCID: PMC3080985.
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    134. BCAP negatively regulates TLR signaling in macrophages (116.13). The Journal of Immunology. 2011 Apr 1; 186(1_Supplement):116.13-116.13. Ni NM, MacFarlane MA, Campbell CK, Lowell LC, Hamerman HJ. .
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    135. Neutrophils give us a shock. J Clin Invest. 2011 Apr; 121(4):1260-3. Lowell CA. PMID: 21436575; PMCID: PMC3069799.
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    136. Paired immunoglobin-like receptor-B regulates the suppressive function and fate of myeloid-derived suppressor cells. Immunity. 2011 Mar 25; 34(3):385-95. Ma G, Pan PY, Eisenstein S, Divino CM, Lowell CA, Takai T, Chen SH. PMID: 21376641; PMCID: PMC3064726.
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    137. Src-family and Syk kinases in activating and inhibitory pathways in innate immune cells: signaling cross talk. Cold Spring Harb Perspect Biol. 2011 Mar 01; 3(3). Lowell CA. PMID: 21068150; PMCID: PMC3039931.
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    138. IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina. J Immunol. 2011 Feb 15; 186(4):2372-81. Nelson MP, Christmann BS, Werner JL, Metz AE, Trevor JL, Lowell CA, Steele C. PMID: 21220696; PMCID: PMC4274743.
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    139. Pyk2 is required for neutrophil degranulation and host defense responses to bacterial infection. J Immunol. 2011 Feb 01; 186(3):1656-65. Kamen LA, Schlessinger J, Lowell CA. PMID: 21187437; PMCID: PMC3248398.
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    140. Interferon-γ production by neutrophils during bacterial pneumonia in mice. Am J Respir Crit Care Med. 2011 May 15; 183(10):1391-401. Yamada M, Gomez JC, Chugh PE, Lowell CA, Dinauer MC, Dittmer DP, Doerschuk CM. PMID: 21169470; PMCID: PMC3114063.
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    141. SYK Is a Tumor Suppressor In Pre-B Cell Acute Lymphoblastic Leukemia and Not a Therapeutic Target. Blood. 2010 Nov 19; 116(21):4199-4199. Ng NC, Nahar NR, Elliott EE, Lowell LC, Muschen MM. .
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    142. Mechanisms of Pre-B Cell Receptor-Inactivation In Acute Lymphoblastic Leukemia. Blood. 2010 Nov 19; 116(21):147-147. Duy DC, Nowak ND, Klemm KL, Nahar NR, Ng NC, Elliott EE, Hofmann HW, Heisterkamp HN, Lowell LC, Koeffler KP, Muschen MM. .
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    143. The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity. Immunity. 2010 Aug 27; 33(2):181-91. Tavares RM, Turer EE, Liu CL, Advincula R, Scapini P, Rhee L, Barrera J, Lowell CA, Utz PJ, Malynn BA, Ma A. PMID: 20705491; PMCID: PMC2931361.
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    144. Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J Exp Med. 2010 Aug 02; 207(8):1757-73. Scapini P, Hu Y, Chu CL, Migone TS, Defranco AL, Cassatella MA, Lowell CA. PMID: 20624892; PMCID: PMC2916124.
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    145. Interim results of a phase I trial of intraventricular rituximab plus methotrexate in recurrent CNS lymphoma: Macrophage polarization and acquired resistance to therapy. Journal of Clinical Oncology. 2010 May 20; 28(15_suppl):2532-2532. Rubenstein RJ, Kadoch KC, Wong WV, Hyun HW, Lowell LC. .
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    146. Abstract 5580: Macrophage polarization and acquired resistance to rituximab in CNS lymphoma. Clinical Research. 2010 Apr 15; 5580-5580. Kadoch KC, Wong WV, Rambaldo RT, Hyun HW, Gao GH, Lowell LC, Rubenstein RJ. .
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    147. Abstract 2728: Multivariate analysis of cerebrospinal fluid protein biomarkers in central nervous system lymphoma patients and controls. Clinical Research. 2010 Apr 15; 2728-2728. Wong WV, Chen CL, Kadoch KC, Tsang TA, Siu SL, Lowell LC, Rubenstein RJ. .
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    148. An important role of the SRC family kinase Lyn in stimulating platelet granule secretion. J Biol Chem. 2010 Apr 23; 285(17):12559-70. Li Z, Zhang G, Liu J, Stojanovic A, Ruan C, Lowell CA, Du X. PMID: 20189992; PMCID: PMC2857081.
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    149. Management practices and phytoremediation by native grasses. Int J Phytoremediation. 2010 Feb; 12(2):200-14. Nedunuri KV, Lowell C, Meade W, Vonderheide AP, Shann JR. PMID: 20734616.
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    150. c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration. FEBS Lett. 2010 Jan 04; 584(1):15-21. Baruzzi A, Iacobucci I, Soverini S, Lowell CA, Martinelli G, Berton G. PMID: 19903482; PMCID: PMC4454382.
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    151. Macrophage Polarization and Acquired Resistance to Rituximab in CNS Lymphoma. Blood. 2009 Nov 20; 114(22):3749-3749. Kadoch KC, Wong WV, Rambaldo RT, Hyun HW, Lowell LC, Rubenstein RJ. .
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    152. Three-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysis. Blood. 2010 Feb 18; 115(7):1444-52. Cougoule C, Le Cabec V, Poincloux R, Al Saati T, Mège JL, Tabouret G, Lowell CA, Laviolette-Malirat N, Maridonneau-Parini I. PMID: 19897576; PMCID: PMC5070714.
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    153. The expanding roles of ITAM adapters FcRgamma and DAP12 in myeloid cells. Immunol Rev. 2009 Nov; 232(1):42-58. Hamerman JA, Ni M, Killebrew JR, Chu CL, Lowell CA. PMID: 19909355; PMCID: PMC3248395.
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    154. Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest. 2009 Nov; 119(11):3450-61. Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay MA. PMID: 19809160; PMCID: PMC2769181.
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    155. Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection. Blood. 2009 Nov 26; 114(23):4871-82. Van Ziffle JA, Lowell CA. PMID: 19797524; PMCID: PMC2786293.
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    156. Microarray kit analysis of cytokines in blood product units and segments. Transfusion. 2009 Nov; 49(11):2269-75. Weiskopf RB, Yau R, Sanchez R, Lowell C, Toy P. PMID: 19548981; PMCID: PMC2783862.
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    157. Leukocyte adhesion deficiency syndrome: a controversy solved. Immunol Cell Biol. 2009 Aug-Sep; 87(6):440-2. Abram CL, Lowell CA. PMID: 19417769; PMCID: PMC4464832.
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    158. Receptor-independent, lipid dependent mechanism of Syk kinase activation in dendritic cells (134.71). The Journal of Immunology. 2009 Apr 1; 182(1_Supplement):134.71-134.71. Ng NG, Sharma SK, Ward WS, Desrosiers DM, Stephens SL, Schoel SM, Li LT, Lowell LC, Ling LC, Amrein AM, Shi SY. .
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    159. CalDAG-GEF-I is required for E-selectin-dependent slow leukocyte rolling (94.2). The Journal of Immunology. 2009 Apr 1; 182(1_Supplement):94.2-94.2. Zarbock ZA, Mueller MH, Bergmeier BW, Lowell LC, Van Aken VH, Wagner WD, Ley LK. .
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    160. Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model. Clin Cancer Res. 2009 Mar 15; 15(6):1989-97. Kadoch C, Dinca EB, Voicu R, Chen L, Nguyen D, Parikh S, Karrim J, Shuman MA, Lowell CA, Treseler PA, James CD, Rubenstein JL. PMID: 19276270; PMCID: PMC4372389.
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    161. The absence of Hck, Fgr, and Lyn tyrosine kinases augments lung innate immune responses to Pneumocystis murina. Infect Immun. 2009 May; 77(5):1790-7. Nelson MP, Metz AE, Li S, Lowell CA, Steele C. PMID: 19255189; PMCID: PMC2681740.
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    162. Multiple roles of Lyn kinase in myeloid cell signaling and function. Immunol Rev. 2009 Mar; 228(1):23-40. Scapini P, Pereira S, Zhang H, Lowell CA. PMID: 19290919; PMCID: PMC3248569.
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    163. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. Journal of Experimental Medicine. 2009 Feb 16; 206(2):i3-i3. N'Diaye NE, Branda BC, Branda BS, Nevarez NL, Colonna CM, Lowell LC, Hamerman HJ, Seaman SW. .
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    164. Erratum: Corrigendum: Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nature Immunology. 2009 Feb 1; 10(2):223-223. Hamerman HJ, Tchao TN, Lowell LC, Lanier LL. .
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    165. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. J Cell Biol. 2009 Jan 26; 184(2):215-23. N'Diaye EN, Branda CS, Branda SS, Nevarez L, Colonna M, Lowell C, Hamerman JA, Seaman WE. PMID: 19171755; PMCID: PMC2654305.
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    166. Generation of a novel system for studying spleen tyrosine kinase function in macrophages and B cells. J Immunol. 2009 Jan 15; 182(2):988-98. Miller AL, Zhang C, Shokat KM, Lowell CA. PMID: 19124742; PMCID: PMC3248399.
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    167. The ins and outs of leukocyte integrin signaling. Annu Rev Immunol. 2009; 27:339-62. Abram CL, Lowell CA. PMID: 19302044; PMCID: PMC3248397.
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    168. Transmigration of neutrophils across inflamed endothelium is signaled through LFA-1 and Src family kinase. J Immunol. 2008 Dec 15; 181(12):8660-9. Sarantos MR, Zhang H, Schaff UY, Dixit N, Hayenga HN, Lowell CA, Simon SI. PMID: 19050286; PMCID: PMC4457456.
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    169. Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells. Immunity. 2008 Nov 14; 29(5):807-18. Ng G, Sharma K, Ward SM, Desrosiers MD, Stephens LA, Schoel WM, Li T, Lowell CA, Ling CC, Amrein MW, Shi Y. PMID: 18993083; PMCID: PMC2642965.
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    170. PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling. J Exp Med. 2008 Sep 29; 205(10):2339-47. Zarbock A, Abram CL, Hundt M, Altman A, Lowell CA, Ley K. PMID: 18794338; PMCID: PMC2556779.
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    171. Evaluation of the physiological significance of botrocetin/ von Willebrand factor in vitro signaling. J Thromb Haemost. 2008 Nov; 6(11):1915-22. Liu J, Joglekar M, Ware J, Fitzgerald ME, Lowell CA, Berndt MC, Gartner TK. PMID: 18752568; PMCID: PMC2982674.
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    172. Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase. J Leukoc Biol. 2008 Oct; 84(4):1141-50. Paul R, Obermaier B, Van Ziffle J, Angele B, Pfister HW, Lowell CA, Koedel U. PMID: 18625913; PMCID: PMC2538596.
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    173. Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway. Blood. 2008 Aug 15; 112(4):1139-46. Yin H, Liu J, Li Z, Berndt MC, Lowell CA, Du X. PMID: 18550847; PMCID: PMC2515128.
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    174. The diverse functions of Src family kinases in macrophages. Front Biosci. 2008 May 01; 13:4426-50. Abram CL, Lowell CA. PMID: 18508521; PMCID: PMC4457449.
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    175. Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5. J Clin Invest. 2008 Mar; 118(3):924-34. Xiao W, Hong H, Kawakami Y, Lowell CA, Kawakami T. PMID: 18246197; PMCID: PMC2214849.
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    176. Increased TLR Responses in Dendritic Cells Lacking the Itam-Containing Adapters Dap12 and FcR?. The FASEB Journal. 2008 Mar 1; 22:1065.36-1065.36. Hamerman HJ, Yu YY, Shen SK, Lowell LC, Lanier LL, Chu CC. .
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    177. Immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters DAP12 and FcR? required for E-selectin mediated slow rolling. The FASEB Journal. 2008 Mar 1; 22:1071.1-1071.1. Zarbock ZA, Lowell LC, Ley LK. .
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    178. Regulation of myeloproliferation and M2 macrophage programming by Lyn/Hck, SHIP and Stat5. The FASEB Journal. 2008 Mar 1; 22:844.9-844.9. Xiao XW, Hong HH, Kawakami KY, Lowell LC, Kawakami KT. .
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    179. Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRgamma. Eur J Immunol. 2008 Jan; 38(1):166-73. Chu CL, Yu YL, Shen KY, Lowell CA, Lanier LL, Hamerman JA. PMID: 18081038; PMCID: PMC2587008.
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    180. Immunoreceptor-like signaling by beta 2 and beta 3 integrins. Trends Cell Biol. 2007 Oct; 17(10):493-501. Jakus Z, Fodor S, Abram CL, Lowell CA, Mócsai A. PMID: 17913496.
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    181. Convergence of immunoreceptor and integrin signaling. Immunol Rev. 2007 Aug; 218:29-44. Abram CL, Lowell CA. PMID: 17624942.
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    182. TRALI--definition, mechanisms, incidence and clinical relevance. Best Pract Res Clin Anaesthesiol. 2007 Jun; 21(2):183-93. Toy P, Lowell C. PMID: 17650771; PMCID: PMC2767181.
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    183. Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1. Immunity. 2007 Jun; 26(6):773-83. Zarbock A, Lowell CA, Ley K. PMID: 17543554; PMCID: PMC2600878.
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    184. The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn. Blood. 2007 Oct 01; 110(7):2511-9. Hong H, Kitaura J, Xiao W, Horejsi V, Ra C, Lowell CA, Kawakami Y, Kawakami T. PMID: 17513616; PMCID: PMC1988937.
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    185. Cutting Edge: B cell receptor (BCR) cross-talk: the IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to Rottlerin, and depends on Lyn. J Immunol. 2007 Apr 15; 178(8):4726-30. Guo B, Blair D, Chiles TC, Lowell CA, Rothstein TL. PMID: 17404251.
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    186. Inhibition of Toll-like receptor and Fc receptor responses in macrophages by TREM-2 and DAP12 (44.7). The Journal of Immunology. 2007 Apr 1; 178(1_Supplement):s49-s49. Hamerman HJ, Jarjoura JJ, Tchao TN, Humphrey HM, Nakamura NM, Lowell LC, Seaman SW, Lanier LL. .
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    187. B Cell Receptor Crosstalk: The IL-4-induced Alternate Pathway for BCR Signaling Operates in Parallel with the Classical Pathway, Is Sensitive to Rottlerin, and Depends on Lyn (86.14). The Journal of Immunology. 2007 Apr 1; 178(1_Supplement):s126-s126. Guo GB, Blair BD, Chiles CT, Lowell LC, Rothstein RT. .
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    188. The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine. J Immunol. 2007 Mar 15; 178(6):3874-85. Fumagalli L, Zhang H, Baruzzi A, Lowell CA, Berton G. PMID: 17339487; PMCID: PMC4683084.
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    189. The expanding role for ITAM-based signaling pathways in immune cells. Sci STKE. 2007 Mar 13; 2007(377):re2. Abram CL, Lowell CA. PMID: 17356173.
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    190. Microarray analysis of a mouse model of transfusion-related acute lung injury (TRALI) reveals prominent increased expression of neutrophil-derived chemokines. The FASEB Journal. 2007 Jan 1; 21(6):a1202-a1202. Looney LM, Barbeau BR, Barczak BA, Xiao XY, Lowell LC, Erle ED, Matthay MM. .
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    191. Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. J Exp Med. 2006 Dec 25; 203(13):2907-17. Xu X, Zhang D, Zhang H, Wolters PJ, Killeen NP, Sullivan BM, Locksley RM, Lowell CA, Caughey GH. PMID: 17158962; PMCID: PMC2118183.
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    192. Src family kinases mediate neutrophil adhesion to adherent platelets. Blood. 2007 Mar 15; 109(6):2461-9. Evangelista V, Pamuklar Z, Piccoli A, Manarini S, Dell'elba G, Pecce R, Martelli N, Federico L, Rojas M, Berton G, Lowell CA, Totani L, Smyth SS. PMID: 17095622; PMCID: PMC1852189.
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    193. Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat Immunol. 2006 Dec; 7(12):1326-33. Mócsai A, Abram CL, Jakus Z, Hu Y, Lanier LL, Lowell CA. PMID: 17086186; PMCID: PMC4698344.
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    194. Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils. Immunity. 2006 Aug; 25(2):285-95. Zhang H, Schaff UY, Green CE, Chen H, Sarantos MR, Hu Y, Wara D, Simon SI, Lowell CA. PMID: 16901726; PMCID: PMC4698343.
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    195. Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Immunity. 2006 Aug; 25(2):271-83. Hirahashi J, Mekala D, Van Ziffle J, Xiao L, Saffaripour S, Wagner DD, Shapiro SD, Lowell C, Mayadas TN. PMID: 16872848.
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    196. The Src family kinases Hck and Fgr are dispensable for inside-out, chemoattractant-induced signaling regulating beta 2 integrin affinity and valency in neutrophils, but are required for beta 2 integrin-mediated outside-in signaling involved in sustained adhesion. J Immunol. 2006 Jul 01; 177(1):604-11. Giagulli C, Ottoboni L, Caveggion E, Rossi B, Lowell C, Constantin G, Laudanna C, Berton G. PMID: 16785558.
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    197. Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis. Blood. 2006 Oct 15; 108(8):2562-8. Mermel CH, McLemore ML, Liu F, Pereira S, Woloszynek J, Lowell CA, Link DC. PMID: 16772601; PMCID: PMC1895577.
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    198. Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest. 2006 Jun; 116(6):1615-23. Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA. PMID: 16710475; PMCID: PMC1462945.
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    199. Lyn kinase promotes erythroblast expansion and late-stage development. Blood. 2006 Sep 01; 108(5):1524-32. Karur VG, Lowell CA, Besmer P, Agosti V, Wojchowski DM. PMID: 16705093; PMCID: PMC1895506.
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    200. Src-family kinases mediate an outside-in signal necessary for beta2 integrins to achieve full activation and sustain firm adhesion of polymorphonuclear leucocytes tethered on E-selectin. Biochem J. 2006 May 15; 396(1):89-98. Totani L, Piccoli A, Manarini S, Federico L, Pecce R, Martelli N, Cerletti C, Piccardoni P, Lowell CA, Smyth SS, Berton G, Evangelista V. PMID: 16433632; PMCID: PMC1449987.
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    201. A role for PKCtheta in outside-in alpha(IIb)beta3 signaling. J Thromb Haemost. 2006 Mar; 4(3):648-55. Soriani A, Moran B, de Virgilio M, Kawakami T, Altman A, Lowell C, Eto K, Shattil SJ. PMID: 16460447.
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    202. Rewiring phagocytic signal transduction. Immunity. 2006 Mar; 24(3):243-5. Lowell CA. PMID: 16546092.
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    203. Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI. J Immunol. 2006 Feb 15; 176(4):2421-9. Yu M, Lowell CA, Neel BG, Gu H. PMID: 16456001.
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    204. Beautiful blistering. Blood. 2006 Feb 1; 107(3):849-850. Lowell LC. .
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    205. Dual function for the adaptor MIST in IFN-gamma production by NK and CD4+NKT cells regulated by the Src kinase Fgr. Blood. 2006 May 01; 107(9):3647-55. Sasanuma H, Tatsuno A, Hidano S, Ohshima K, Matsuzaki Y, Hayashi K, Lowell CA, Kitamura D, Goitsuka R. PMID: 16439675.
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    206. Increased expression of genes linked to FcepsilonRI Signaling and to cytokine and chemokine production in Lyn-deficient mast cells. J Immunol. 2005 Dec 15; 175(12):7880-8. Hernandez-Hansen V, Bard JD, Tarleton CA, Wilder JA, Lowell CA, Wilson BS, Oliver JM. PMID: 16339523.
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    207. Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI. J Immunol. 2005 Nov 15; 175(10):6885-92. Xiao W, Nishimoto H, Hong H, Kitaura J, Nunomura S, Maeda-Yamamoto M, Kawakami Y, Lowell CA, Ra C, Kawakami T. PMID: 16272347; PMCID: PMC1415265.
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    208. Regulation of K-Cl cotransport by protein phosphatase 1alpha in mouse erythrocytes. Pflugers Arch. 2006 Mar; 451(6):760-8. De Franceschi L, Villa-Moruzzi E, Biondani A, Siciliano A, Brugnara C, Alper SL, Lowell CA, Berton G. PMID: 16283202.
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    209. G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth. Blood. 2006 Mar 01; 107(5):1847-56. Zhu QS, Xia L, Mills GB, Lowell CA, Touw IP, Corey SJ. PMID: 16282349; PMCID: PMC1895701.
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    210. The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4. Biochem Pharmacol. 2005 Oct 15; 70(8):1231-40. Lee JY, Lowell CA, Lemay DG, Youn HS, Rhee SH, Sohn KH, Jang B, Ye J, Chung JH, Hwang DH. PMID: 16140274.
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    211. The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation. J Immunol. 2005 Sep 01; 175(5):2880-9. Chu CL, Lowell CA. PMID: 16116174.
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    212. Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. Blood. 2005 Oct 01; 106(7):2543-50. Underhill DM, Rossnagle E, Lowell CA, Simmons RM. PMID: 15956283; PMCID: PMC1895265.
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    213. Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat Immunol. 2005 Jun; 6(6):579-86. Hamerman JA, Tchao NK, Lowell CA, Lanier LL. PMID: 15895090; PMCID: PMC1282462.
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    214. Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases. J Immunol. 2005 Apr 15; 174(8):4495-504. Kitaura J, Eto K, Kinoshita T, Kawakami Y, Leitges M, Lowell CA, Kawakami T. PMID: 15814670.
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    215. Src and Syk kinases: key regulators of phagocytic cell activation. Trends Immunol. 2005 Apr; 26(4):208-14. Berton G, Mócsai A, Lowell CA. PMID: 15797511.
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    216. Minimum conditions of major histocompatibility complex compatibility and recipient immune compromise required to establish donor white blood cell persistence in a murine transfusion model. Transfusion. 2005 Mar; 45(3):301-14. Lee TH, Wen L, Montalvo L, Esho O, Lowell C, Reed W, Busch M. PMID: 15752147.
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    217. The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B. Immunity. 2005 Feb; 22(2):235-46. Zhang H, Meng F, Chu CL, Takai T, Lowell CA. PMID: 15723811.
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    218. The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization. Exp Cell Res. 2005 Jan 15; 302(2):253-69. Continolo S, Baruzzi A, Majeed M, Caveggion E, Fumagalli L, Lowell CA, Berton G. PMID: 15561106.
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    219. IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion. Blood. 2005 Apr 15; 105(8):3222-9. Kitaura J, Kinoshita T, Matsumoto M, Chung S, Kawakami Y, Leitges M, Wu D, Lowell CA, Kawakami T. PMID: 15637135; PMCID: PMC1464406.
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    220. Lyn Kinase Supports Primary Erythroid Progenitor Cell Development. Blood. 2004 Nov 16; 104(11):1622-1622. Karur KV, Vincent VB, Lowell LC, Wojchowski WD. .
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    222. Amplification of IFN-alpha-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors. Nat Immunol. 2004 Nov; 5(11):1181-9. Tassiulas I, Hu X, Ho H, Kashyap Y, Paik P, Hu Y, Lowell CA, Ivashkiv LB. PMID: 15467722.
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    223. Early divergence of Fc epsilon receptor I signals for receptor up-regulation and internalization from degranulation, cytokine production, and survival. J Immunol. 2004 Oct 01; 173(7):4317-23. Kitaura J, Xiao W, Maeda-Yamamoto M, Kawakami Y, Lowell CA, Kawakami T. PMID: 15383560.
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    224. Responses of neutrophils to anti-integrin antibodies depends on costimulation through low affinity Fc gamma Rs: full activation requires both integrin and nonintegrin signals. J Immunol. 2004 Aug 01; 173(3):2068-77. Jakus Z, Berton G, Ligeti E, Lowell CA, Mócsai A. PMID: 15265942.
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    225. Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury. J Clin Invest. 2004 Jul; 114(1):49-56. Chou WH, Choi DS, Zhang H, Mu D, McMahon T, Kharazia VN, Lowell CA, Ferriero DM, Messing RO. PMID: 15232611; PMCID: PMC437973.
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    226. Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells. J Immunol. 2004 Jul 01; 173(1):100-12. Hernandez-Hansen V, Smith AJ, Surviladze Z, Chigaev A, Mazel T, Kalesnikoff J, Lowell CA, Krystal G, Sklar LA, Wilson BS, Oliver JM. PMID: 15210764.
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    227. Src-family kinases: rheostats of immune cell signaling. Mol Immunol. 2004 Jul; 41(6-7):631-43. Lowell CA. PMID: 15220000.
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    228. CXCL1/macrophage inflammatory protein-2-induced angiogenesis in vivo is mediated by neutrophil-derived vascular endothelial growth factor-A. J Immunol. 2004 Apr 15; 172(8):5034-40. Scapini P, Morini M, Tecchio C, Minghelli S, Di Carlo E, Tanghetti E, Albini A, Lowell C, Berton G, Noonan DM, Cassatella MA. PMID: 15067085.
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    229. The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc Natl Acad Sci U S A. 2004 Apr 20; 101(16):6158-63. Mócsai A, Humphrey MB, Van Ziffle JA, Hu Y, Burghardt A, Spusta SC, Majumdar S, Lanier LL, Lowell CA, Nakamura MC. PMID: 15073337; PMCID: PMC395939.
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    230. SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophils. Immunity. 2003 Nov; 19(5):761-9. Newbrough SA, Mocsai A, Clemens RA, Wu JN, Silverman MA, Singer AL, Lowell CA, Koretzky GA. PMID: 14614862.
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    231. Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12911-6. Kitaura J, Song J, Tsai M, Asai K, Maeda-Yamamoto M, Mocsai A, Kawakami Y, Liu FT, Lowell CA, Barisas BG, Galli SJ, Kawakami T. PMID: 14569021; PMCID: PMC240718.
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    232. The Src kinase Lyn is a negative regulator of mast cell proliferation. J Leukoc Biol. 2004 Jan; 75(1):143-51. Hernandez-Hansen V, Mackay GA, Lowell CA, Wilson BS, Oliver JM. PMID: 14525964.
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    233. Reduced dosage of Bruton's tyrosine kinase uncouples B cell hyperresponsiveness from autoimmunity in lyn-/- mice. J Immunol. 2003 Aug 15; 171(4):1850-8. Whyburn LR, Halcomb KE, Contreras CM, Lowell CA, Witte ON, Satterthwaite AB. PMID: 12902486.
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    234. The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling. J Immunol. 2003 Aug 01; 171(3):1319-27. Pereira S, Lowell C. PMID: 12874221.
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    235. Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading. Immunity. 2003 Jul; 19(1):95-104. Chen H, Mocsai A, Zhang H, Ding RX, Morisaki JH, White M, Rothfork JM, Heiser P, Colucci-Guyon E, Lowell CA, Gresham HD, Allen PM, Brown EJ. PMID: 12871642.
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    236. Expression and tyrosine phosphorylation of Cbl regulates macrophage chemokinetic and chemotactic movement. J Cell Physiol. 2003 May; 195(2):276-89. Caveggion E, Continolo S, Pixley FJ, Stanley ER, Bowtell DD, Lowell CA, Berton G. PMID: 12652654.
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    237. Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development. Nat Immunol. 2003 Mar; 4(3):274-9. Saijo K, Schmedt C, Su IH, Karasuyama H, Lowell CA, Reth M, Adachi T, Patke A, Santana A, Tarakhovsky A. PMID: 12563261.
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    238. G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells. Blood. 2003 May 15; 101(10):4155-63. Mócsai A, Zhang H, Jakus Z, Kitaura J, Kawakami T, Lowell CA. PMID: 12531806.
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    239. Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science. 2003 Jan 10; 299(5604):247-51. Abtahian F, Guerriero A, Sebzda E, Lu MM, Zhou R, Mocsai A, Myers EE, Huang B, Jackson DG, Ferrari VA, Tybulewicz V, Lowell CA, Lepore JJ, Koretzky GA, Kahn ML. PMID: 12522250; PMCID: PMC2982679.
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    240. Tumor necrosis factor-alpha-induced leukocyte adhesion and microvessel permeability. Am J Physiol Heart Circ Physiol. 2002 Dec; 283(6):H2420-30. Zeng M, Zhang H, Lowell C, He P. PMID: 12388263.
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    241. Fgr deficiency results in defective eosinophil recruitment to the lung during allergic airway inflammation. J Immunol. 2002 Jun 15; 168(12):6446-54. Vicentini L, Mazzi P, Caveggion E, Continolo S, Fumagalli L, Lapinet-Vera JA, Lowell CA, Berton G. PMID: 12055264.
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    242. Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J Cell Biol. 2002 Apr 15; 157(2):265-75. Obergfell A, Eto K, Mocsai A, Buensuceso C, Moores SL, Brugge JS, Lowell CA, Shattil SJ. PMID: 11940607; PMCID: PMC2199242.
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    244. Role of the Src family kinase Lyn in TxA2 production, adenosine diphosphate secretion, Akt phosphorylation, and irreversible aggregation in platelets stimulated with gamma-thrombin. Blood. 2002 Apr 01; 99(7):2442-7. Cho MJ, Pestina TI, Steward SA, Lowell CA, Jackson CW, Gartner TK. PMID: 11895777.
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    245. Lyn tyrosine kinase is important for IL-5-stimulated eosinophil differentiation. J Immunol. 2002 Feb 15; 168(4):1978-83. Stafford S, Lowell C, Sur S, Alam R. PMID: 11823534.
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    246. Role of Src kinases and Syk in Fcgamma receptor-mediated phagocytosis and phagosome-lysosome fusion. J Leukoc Biol. 2001 Nov; 70(5):801-11. Majeed M, Caveggion E, Lowell CA, Berton G. PMID: 11698501.
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    247. Non-immunogenic murine hepatocellular carcinoma Hepa1-6 cells expressing the membrane form of macrophage colony stimulating factor are rejected in vivo and lead to CD8+ T-cell immunity against the parental tumor. Mol Ther. 2001 Nov; 4(5):427-37. Dan Q, Sanchez R, Delgado C, Wepsic HT, Morgan K, Chen Y, Jeffes EW, Lowell CA, Morgan TR, Jadus MR. PMID: 11708879.
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    248. The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck. J Virol. 2001 Oct; 75(19):9378-92. Hanna Z, Weng X, Kay DG, Poudrier J, Lowell C, Jolicoeur P. PMID: 11533201; PMCID: PMC114506.
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    249. Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity. 2001 Oct; 15(4):507-19. Vines CM, Potter JW, Xu Y, Geahlen RL, Costello PS, Tybulewicz VL, Lowell CA, Chang PW, Gresham HD, Willman CL. PMID: 11672534.
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    250. A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice. J Immunol. 2001 Sep 01; 167(5):2469-78. Hasegawa M, Fujimoto M, Poe JC, Steeber DA, Lowell CA, Tedder TF. PMID: 11509585.
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    251. Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells. Blood. 2001 Jul 15; 98(2):343-50. O'Laughlin-Bunner B, Radosevic N, Taylor ML, DeBerry C, Metcalfe DD, Zhou M, Lowell C, Linnekin D. PMID: 11435302.
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    252. Resting murine neutrophils express functional alpha 4 integrins that signal through Src family kinases. J Immunol. 2001 Mar 15; 166(6):4115-23. Pereira S, Zhou M, Mócsai A, Lowell C. PMID: 11238661.
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    253. Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn. Curr Biol. 2001 Jan 09; 11(1):34-8. Yu CC, Yen TS, Lowell CA, DeFranco AL. PMID: 11166177.
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    254. Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway. Blood. 2000 Dec 15; 96(13):4246-53. Quek LS, Pasquet JM, Hers I, Cornall R, Knight G, Barnes M, Hibbs ML, Dunn AR, Lowell CA, Watson SP. PMID: 11110698.
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    257. Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation. J Immunol. 2000 Aug 01; 165(3):1210-9. Kawakami Y, Kitaura J, Satterthwaite AB, Kato RM, Asai K, Hartman SE, Maeda-Yamamoto M, Lowell CA, Rawlings DJ, Witte ON, Kawakami T. PMID: 10903718.
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    258. CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification. Immunity. 2000 Jul; 13(1):47-57. Fujimoto M, Fujimoto Y, Poe JC, Jansen PJ, Lowell CA, DeFranco AL, Tedder TF. PMID: 10933394.
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    259. Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7423-8. Kawakami Y, Kitaura J, Hartman SE, Lowell CA, Siraganian RP, Kawakami T. PMID: 10852954; PMCID: PMC16561.
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    260. A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6687-92. Satterthwaite AB, Willis F, Kanchanastit P, Fruman D, Cantley LC, Helgason CD, Humphries RK, Lowell CA, Simon M, Leitges M, Tarakhovsky A, Tedder TF, Lesche R, Wu H, Witte ON. PMID: 10829070; PMCID: PMC18703.
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    262. Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharide-stimulated nitric oxide production in macrophages via interferon-beta. J Leukoc Biol. 2000 Mar; 67(3):405-14. Weinstein SL, Finn AJ, Davé SH, Meng F, Lowell CA, Sanghera JS, DeFranco AL. PMID: 10733102.
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    273. The molecular mechanism of B cell activation by toll-like receptor protein RP-105. J Exp Med. 1998 Jul 06; 188(1):93-101. Chan VW, Mecklenbräuker I, Su I, Texido G, Leitges M, Carsetti R, Lowell CA, Rajewsky K, Miyake K, Tarakhovsky A. PMID: 9653087; PMCID: PMC2525555.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    274. Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr. Proc Natl Acad Sci U S A. 1998 Jun 23; 95(13):7580-4. Lowell CA, Berton G. PMID: 9636192; PMCID: PMC22689.
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    275. Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes. Curr Biol. 1998 May 07; 8(10):545-53. Chan VW, Lowell CA, DeFranco AL. PMID: 9601638.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    276. Macrophages kill T9 glioma tumor cells bearing the membrane isoform of macrophage colony stimulating factor through a phagocytosis-dependent pathway. J Immunol. 1998 Jan 01; 160(1):361-8. Jadus MR, Williams CC, Avina MD, Ly M, Kim S, Liu Y, Narasaki R, Lowell CA, Wepsic HT. PMID: 9551992.
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    277. Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice. Genes Dev. 1997 Nov 01; 11(21):2835-44. Schwartzberg PL, Xing L, Hoffmann O, Lowell CA, Garrett L, Boyce BF, Varmus HE. PMID: 9353253; PMCID: PMC316651.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    278. A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages. J Exp Med. 1997 Oct 06; 186(7):1027-39. Crowley MT, Costello PS, Fitzer-Attas CJ, Turner M, Meng F, Lowell C, Tybulewicz VL, DeFranco AL. PMID: 9314552; PMCID: PMC2199061.
      View in: PubMed   Mentions: 132     Fields:    Translation:AnimalsCells
    279. Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity. 1997 Jul; 7(1):69-81. Chan VW, Meng F, Soriano P, DeFranco AL, Lowell CA. PMID: 9252121.
      View in: PubMed   Mentions: 133     Fields:    Translation:AnimalsCells
    280. Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn. J Exp Med. 1997 May 05; 185(9):1661-70. Meng F, Lowell CA. PMID: 9151903; PMCID: PMC2196288.
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    281. Deficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport. J Clin Invest. 1997 Jan 15; 99(2):220-7. De Franceschi L, Fumagalli L, Olivieri O, Corrocher R, Lowell CA, Berton G. PMID: 9005990; PMCID: PMC507789.
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    282. Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories. Genes Dev. 1996 Aug 01; 10(15):1845-57. Lowell CA, Soriano P. PMID: 8756343.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    283. Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions. J Cell Biol. 1996 May; 133(4):895-910. Lowell CA, Fumagalli L, Berton G. PMID: 8666673; PMCID: PMC2120842.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    284. Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis. Blood. 1996 Mar 01; 87(5):1780-92. Lowell CA, Niwa M, Soriano P, Varmus HE. PMID: 8634424.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    285. Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis. Blood. 1996 Mar 1; 87(5):1780-1792. Lowell LC, Niwa NM, Soriano SP, Varmus VH. .
      View in: Publisher Site   Mentions:
    286. Neutrophil activation by adhesion: mechanisms and pathophysiological implications. Int J Clin Lab Res. 1996; 26(3):160-77. Berton G, Yan SR, Fumagalli L, Lowell CA. PMID: 8905448.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    287. Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. Genes Dev. 1994 Feb 15; 8(4):387-98. Lowell CA, Soriano P, Varmus HE. PMID: 8125254.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    288. Cancer genes and hematopoiesis. Blood. 1994 Jan 01; 83(1):5-9. Varmus HE, Lowell CA. PMID: 8274752.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    289. Mapping of the Epstein-Barr virus and C3dg binding sites to a common domain on complement receptor type 2. J Exp Med. 1989 Dec 01; 170(6):1931-46. Lowell CA, Klickstein LB, Carter RH, Mitchell JA, Fearon DT, Ahearn JM. PMID: 2479703; PMCID: PMC2189535.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    290. Sucrose-metabolizing enzymes in transport tissues and adjacent sink structures in developing citrus fruit. Plant Physiol. 1989 Aug; 90(4):1394-402. Lowell CA, Tomlinson PT, Koch KE. PMID: 16666942; PMCID: PMC1061902.
      View in: PubMed   Mentions: 45     Fields:    
    291. Fenoprofen-induced immune hemolysis. Difficulties in diagnosis and complications in compatibility testing. Am J Clin Pathol. 1988 Mar; 89(3):410-4. Shirey RS, Morton SJ, Lawton KB, Lowell C, Kickler TS, Ness PM. PMID: 3348176.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    292. Transcriptional regulation of serum amyloid A gene expression. J Biol Chem. 1986 Jun 25; 261(18):8453-61. Lowell CA, Stearman RS, Morrow JF. PMID: 2424896.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    293. Structure of the murine serum amyloid A gene family. Gene conversion. J Biol Chem. 1986 Jun 25; 261(18):8442-52. Lowell CA, Potter DA, Stearman RS, Morrow JF. PMID: 3013853.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    294. The sequence and structure of a new serum amyloid A gene. Nucleic Acids Res. 1986 Jan 24; 14(2):797-809. Stearman RS, Lowell CA, Peltzman CG, Morrow JF. PMID: 3003697; PMCID: PMC339465.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    295. Regulation of synthesis of amyloid A-related protein. Ann N Y Acad Sci. 1982; 389:106-15. Stearman RS, Lowell CA, Pearson WR, Morrow JF. PMID: 6953913.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    296. Mechanism of mitochondrial DNA replication in mouse L-cells. Replication of unicircular dimer molecules. J Mol Biol. 1981 May 05; 148(1):77-93. Bogenhagen D, Lowell C, Clayton DA. PMID: 7310869.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    297. S1 nuclease-specific nicking of mitochondrial DNA containing displacement loops. Anal Biochem. 1978 Dec; 91(2):521-31. Lowell C, Bogenhagen D, Clayton DA. PMID: 9762139.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    298. Topical anesthetic effectiveness. An old and new product evaluated. N Y J Dent. 1972 Nov; 38(9):549-50. Howitt JW, Lowell C. PMID: 4562117.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    299. Topical anesthetic effectiveness. An old and new product evaluated. N Y State Dent J. 1972 Nov; 38(9):549-50. Howitt JW, Lowell C. PMID: 4578243.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
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