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Hilde Schjerven, PhD

Title(s)Assistant Professor, Laboratory Medicine
SchoolSchool of Medicine
Phone415-502-3553
ORCID ORCID Icon0000-0001-9287-3375 Additional info
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    Collapse Biography 
    Collapse Awards and Honors
    Oncology Research Fund (Administered by UCSF HDFCCC)2018  - 2020Research Award
    Academic Senate, UCSF2020  - 2021Pilot for Junior Investigators

    Collapse Overview 
    Collapse Overview
    Member, UCSF Bakar ImmunoX

    Member, UCSF Helen Diller Family Comprehensive Cancer Center (Hematopoietic Malignancies Program)

    Member, UCSF Precision Medicine in Rheumatology (PREMIER) Center

    Collapse Research 
    Collapse Research Activities and Funding
    Understanding Ikaros molecular functions for targeted therapies of pre-B ALL
    NIH/NCI R01CA230618Jul 25, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Role of the transcription factor Ikaros in development of autoimmune disease
    NIH/NIAID R01AI127709Jun 15, 2018 - May 31, 2023
    Role: Principal Investigator
    Mechanism of Ikaros Tumor Suppression in progenitor B cell leukemia
    NIH/NCI R21CA209229Jul 9, 2016 - Jun 30, 2018
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Faculty Mentoring
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Park E, Chen J, Moore A, Mangolini M, Santoro A, Boyd JR, Schjerven H, Ecker V, Buchner M, Williamson JC, Lehner PJ, Gasparoli L, Williams O, Bloehdorn J, Stilgenbauer S, Leitges M, Egle A, Schmidt-Supprian M, Frietze S, Ringshausen I. Stromal cell protein kinase C-ß inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance. Sci Transl Med. 2020 Jan 15; 12(526). PMID: 31941829.
      View in: PubMed
    2. Fistonich C, Zehentmeier S, Bednarski JJ, Miao R, Schjerven H, Sleckman BP, Pereira JP. Cell circuits between B cell progenitors and IL-7+ mesenchymal progenitor cells control B cell development. J Exp Med. 2018 10 01; 215(10):2586-2599. PMID: 30158115.
      View in: PubMed
    3. Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2018 06; 558(7711):E5. PMID: 29849140.
      View in: PubMed
    4. Van Nieuwenhove E, Garcia-Perez JE, Helsen C, Rodriguez PD, van Schouwenburg PA, Dooley J, Schlenner S, van der Burg M, Verhoeyen E, Gijsbers R, Frietze S, Schjerven H, Meyts I, Claessens F, Humblet-Baron S, Wouters C, Liston A. A kindred with mutant IKAROS and autoimmunity. J Allergy Clin Immunol. 2018 08; 142(2):699-702.e12. PMID: 29705243.
      View in: PubMed
    5. Ye J, Qiu J, Bostick JW, Ueda A, Schjerven H, Li S, Jobin C, Chen ZE, Zhou L. The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells. Cell Rep. 2017 Nov 21; 21(8):2277-2290. PMID: 29166616.
      View in: PubMed
    6. Lai N. Chan, Zhengshan Chen, Gang Xiao, Jae Woong Lee, Kadriye Nehir Cosgun, Huimin Geng, Valeria Cazzaniga, Hilde Schjerven, Ross A. Dickins, Markus Muschen. Abstract 93: Transcriptional control of glucocorticoid responses in leukemia. Experimental and Molecular Therapeutics. 2017 Jul 1; 93-93.
      View in: Publisher Site
    7. Katerndahl CDS, Heltemes-Harris LM, Willette MJL, Henzler CM, Frietze S, Yang R, Schjerven H, Silverstein KAT, Ramsey LB, Hubbard G, Wells AD, Kuiper RP, Scheijen B, van Leeuwen FN, Müschen M, Kornblau SM, Farrar MA. Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival. Nat Immunol. 2017 06; 18(6):694-704. PMID: 28369050.
      View in: PubMed
    8. Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2017 02 23; 542(7642):479-483. PMID: 28192788.
      View in: PubMed
    9. Schjerven H, Ayongaba EF, Aghajanirefah A, McLaughlin J, Cheng D, Geng H, Boyd JR, Eggesbø LM, Lindeman I, Heath JL, Park E, Witte ON, Smale ST, Frietze S, Müschen M. Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre-B ALL. J Exp Med. 2017 03 06; 214(3):793-814. PMID: 28190001.
      View in: PubMed
    10. Li S, Heller JJ, Bostick JW, Lee A, Schjerven H, Kastner P, Chan S, Chen ZE, Zhou L. Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway. Immunity. 2016 07 19; 45(1):185-97. PMID: 27438771.
      View in: PubMed
    11. Arenzana TL, Schjerven H, Smale ST. Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor. Genes Dev. 2015 Sep 01; 29(17):1801-16. PMID: 26314708.
      View in: PubMed
    12. Song C, Gowda C, Pan X, Ding Y, Tong Y, Tan BH, Wang H, Muthusami S, Ge Z, Sachdev M, Amin SG, Desai D, Gowda K, Gowda R, Robertson GP, Schjerven H, Muschen M, Payne KJ, Dovat S. Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia. Blood. 2015 Oct 08; 126(15):1813-22. PMID: 26219304.
      View in: PubMed
    13. Buchner M, Park E, Geng H, Klemm L, Flach J, Passegué E, Schjerven H, Melnick A, Paietta E, Kopanja D, Raychaudhuri P, Müschen M. Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia. Nat Commun. 2015 Mar 10; 6:6471. PMID: 25753524.
      View in: PubMed
    14. Seyedmehdi Shojaee, Valeria Cazzaniga, Hilde Schjerven, Maike Buchner, Christian Hurtz, Huimin Geng, Andreas Hochhaus, Giovanni Cazzaniga, Ari M Melnick, Steven M. Kornblau, Thomas G Graeber, Markus Muschen. PTEN Is Essential for Normal Cytokine Signaling and Oncogenic Transformation of Pre-B Cells. Blood. 2014 Dec 6; 124(21):262-262.
      View in: Publisher Site
    15. Shojaee Seyedmehdi, Zhengshan Chen, Maike Buchner, Christian Hurtz, Huimin Geng, Hilde Schjerven, Lai N Chan, Phillip Koeffler, Cheryl L. Willman, Stephen Hunger, Sinisa Dovat, Elisabeth Paietta, Wolf-Karsten Hofmann, Ari M Melnick, Warren S. Alexander, Steven M. Kornblau, Markus Muschen. Erk and Stat5 Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia. Blood. 2014 Dec 6; 124(21):787-787.
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    16. Heller JJ, Schjerven H, Li S, Lee A, Qiu J, Chen ZM, Smale ST, Zhou L. Restriction of IL-22-producing T cell responses and differential regulation of regulatory T cell compartments by zinc finger transcription factor Ikaros. J Immunol. 2014 Oct 15; 193(8):3934-46. PMID: 25194055.
      View in: PubMed
    17. Schjerven H, McLaughlin J, Arenzana TL, Frietze S, Cheng D, Wadsworth SE, Lawson GW, Bensinger SJ, Farnham PJ, Witte ON, Smale ST. Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros. Nat Immunol. 2013 Oct; 14(10):1073-83. PMID: 24013668.
      View in: PubMed
    18. Jennifer Heller, Hilde Schjerven, Ju Qiu, Aileen Lee, Stephen Smale, Liang Zhou. 118 Modulation of Treg and Th17 fate decision by selective ikaros zinc fingers. Cytokine. 2013 Sep 1; 63(3):271.
      View in: Publisher Site
    19. Reynaud D, Demarco IA, Reddy KL, Schjerven H, Bertolino E, Chen Z, Smale ST, Winandy S, Singh H. Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros. Nat Immunol. 2008 Aug; 9(8):927-36. PMID: 18568028.
      View in: PubMed
    20. Finn-Eirik Johansen, Ranveig Braathen, Else Munthe, Hilde Schjerven, Per Brandtzaeg. Regulation of the Mucosal IgA System. Mucosal Immune Defense: Immunoglobulin A. 2007 Jan 1; 111-143.
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    21. Schneeman TA, Bruno ME, Schjerven H, Johansen FE, Chady L, Kaetzel CS. Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses. J Immunol. 2005 Jul 01; 175(1):376-84. PMID: 15972671.
      View in: PubMed
    22. Schjerven H, Tran TN, Brandtzaeg P, Johansen FE. De novo synthesized RelB mediates TNF-induced up-regulation of the human polymeric Ig receptor. J Immunol. 2004 Aug 01; 173(3):1849-57. PMID: 15265917.
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    23. Mørk G, Schjerven H, Mangschau L, Søyland E, Brandtzaeg P. Proinflammatory cytokines upregulate expression of calprotectin (L1 protein, MRP-8/MRP-14) in cultured human keratinocytes. Br J Dermatol. 2003 Sep; 149(3):484-91. PMID: 14510979.
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    24. Schjerven H, Brandtzaeg P, Johansen FE. Hepatocyte NF-1 and STAT6 cooperate with additional DNA-binding factors to activate transcription of the human polymeric Ig receptor gene in response to IL-4. J Immunol. 2003 Jun 15; 170(12):6048-56. PMID: 12794133.
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    25. Schjerven H, Brandtzaeg P, Johansen FE. A novel NF-kappa B/Rel site in intron 1 cooperates with proximal promoter elements to mediate TNF-alpha-induced transcription of the human polymeric Ig receptor. J Immunol. 2001 Dec 01; 167(11):6412-20. PMID: 11714807.
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    26. Schjerven H, Brandtzaeg P, Johansen FE. Mechanism of IL-4-mediated up-regulation of the polymeric Ig receptor: role of STAT6 in cell type-specific delayed transcriptional response. J Immunol. 2000 Oct 01; 165(7):3898-906. PMID: 11034397.
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    27. Ertesvåg H, Høidal HK, Schjerven H, Svanem BI, Valla S. Mannuronan C-5-epimerases and their application for in vitro and in vivo design of new alginates useful in biotechnology. Metab Eng. 1999 Jul; 1(3):262-9. PMID: 10937941.
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    28. Norderhaug IN, Johansen FE, Schjerven H, Brandtzaeg P. Regulation of the formation and external transport of secretory immunoglobulins. Crit Rev Immunol. 1999; 19(5-6):481-508. PMID: 10647747.
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    29. F.-E. Johansen, H. Schjerven, I. N. Norderhaug, P. Brandtzaeg. Regulation of the Formation and External Transport of Secretory Immunoglobulins. Critical Reviews in Immunology. 1999 Jan 1; 19(5-6):28.
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    30. van Ginkel PR, Hsiao KM, Schjerven H, Farnham PJ. E2F-mediated growth regulation requires transcription factor cooperation. J Biol Chem. 1997 Jul 18; 272(29):18367-74. PMID: 9218478.
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