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Hilde Schjerven, PhD

Title(s)Assistant Professor, Laboratory Medicine
SchoolSchool of Medicine
Phone415-502-3553
ORCID ORCID Icon0000-0001-9287-3375 Additional info
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    Collapse Biography 
    Collapse Awards and Honors
    Oncology Research Fund (Administered by UCSF HDFCCC)2018  - 2020Research Award
    Academic Senate, UCSF2020  - 2021Pilot for Junior Investigators

    Collapse Overview 
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    Member, UCSF Bakar ImmunoX

    Member, UCSF Helen Diller Family Comprehensive Cancer Center (Hematopoietic Malignancies Program)

    Member, UCSF Precision Medicine in Rheumatology (PREMIER) Center

    Collapse Research 
    Collapse Research Activities and Funding
    Understanding Ikaros molecular functions for targeted therapies of pre-B ALL
    NIH R01CA230618Jul 25, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Role of the transcription factor Ikaros in development of autoimmune disease
    NIH R01AI127709Jun 15, 2018 - May 31, 2023
    Role: Principal Investigator
    Mechanism of Ikaros Tumor Suppression in progenitor B cell leukemia
    NIH R21CA209229Jul 9, 2016 - Jun 30, 2018
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia. (Review, Submitted 2021). Available as Preprint. 2021. Rodriguez PD, Paculova H, Kogut S, Heath J, Schjerven H, Frietze S. View Publication.
    2. Stromal cell protein kinase C-ß inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance. Sci Transl Med. 2020 01 15; 12(526). Park E, Chen J, Moore A, Mangolini M, Santoro A, Boyd JR, Schjerven H, Ecker V, Buchner M, Williamson JC, Lehner PJ, Gasparoli L, Williams O, Bloehdorn J, Stilgenbauer S, Leitges M, Egle A, Schmidt-Supprian M, Frietze S, Ringshausen I. PMID: 31941829.
      View in: PubMed   Mentions: 1     Fields:    
    3. Cell circuits between B cell progenitors and IL-7+ mesenchymal progenitor cells control B cell development. J Exp Med. 2018 10 01; 215(10):2586-2599. Fistonich C, Zehentmeier S, Bednarski JJ, Miao R, Schjerven H, Sleckman BP, Pereira JP. PMID: 30158115.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    4. Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2018 06; 558(7711):E5. PMID: 29849140.
      View in: PubMed   Mentions:    Fields:    
    5. A kindred with mutant IKAROS and autoimmunity. J Allergy Clin Immunol. 2018 08; 142(2):699-702.e12. Van Nieuwenhove E, Garcia-Perez JE, Helsen C, Rodriguez PD, van Schouwenburg PA, Dooley J, Schlenner S, van der Burg M, Verhoeyen E, Gijsbers R, Frietze S, Schjerven H, Meyts I, Claessens F, Humblet-Baron S, Wouters C, Liston A. PMID: 29705243.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    6. The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells. Cell Rep. 2017 Nov 21; 21(8):2277-2290. PMID: 29166616.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    7. Abstract 93: Transcriptional control of glucocorticoid responses in leukemia. Experimental and Molecular Therapeutics. 2017 Jul 1; 93-93. Lai N. Chan, Zhengshan Chen, Gang Xiao, Jae Woong Lee, Kadriye Nehir Cosgun, Huimin Geng, Valeria Cazzaniga, Hilde Schjerven, Ross A. Dickins, Markus Muschen. .
      View in: Publisher Site   Mentions:
    8. Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival. Nat Immunol. 2017 06; 18(6):694-704. Katerndahl CDS, Heltemes-Harris LM, Willette MJL, Henzler CM, Frietze S, Yang R, Schjerven H, Silverstein KAT, Ramsey LB, Hubbard G, Wells AD, Kuiper RP, Scheijen B, van Leeuwen FN, Müschen M, Kornblau SM, Farrar MA. PMID: 28369050.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    9. Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2017 02 23; 542(7642):479-483. PMID: 28192788.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    10. Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre-B ALL. J Exp Med. 2017 03 06; 214(3):793-814. PMID: 28190001.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    11. Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway. Immunity. 2016 07 19; 45(1):185-97. PMID: 27438771.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    12. Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor. Genes Dev. 2015 Sep 01; 29(17):1801-16. PMID: 26314708.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    13. Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia. Blood. 2015 Oct 08; 126(15):1813-22. PMID: 26219304.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    14. Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia. Nat Commun. 2015 Mar 10; 6:6471. PMID: 25753524.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    15. PTEN Is Essential for Normal Cytokine Signaling and Oncogenic Transformation of Pre-B Cells. Blood. 2014 Dec 6; 124(21):262-262. Seyedmehdi Shojaee, Valeria Cazzaniga, Hilde Schjerven, Maike Buchner, Christian Hurtz, Huimin Geng, Andreas Hochhaus, Giovanni Cazzaniga, Ari M Melnick, Steven M. Kornblau, Thomas G Graeber, Markus Muschen. .
      View in: Publisher Site   Mentions:
    16. Erk and Stat5 Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia. Blood. 2014 Dec 6; 124(21):787-787. Shojaee Seyedmehdi, Zhengshan Chen, Maike Buchner, Christian Hurtz, Huimin Geng, Hilde Schjerven, Lai N Chan, Phillip Koeffler, Cheryl L. Willman, Stephen Hunger, Sinisa Dovat, Elisabeth Paietta, Wolf-Karsten Hofmann, Ari M Melnick, Warren S. Alexander, Steven M. Kornblau, Markus Muschen. .
      View in: Publisher Site   Mentions:
    17. Restriction of IL-22-producing T cell responses and differential regulation of regulatory T cell compartments by zinc finger transcription factor Ikaros. J Immunol. 2014 Oct 15; 193(8):3934-46. PMID: 25194055.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    18. Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros. Nat Immunol. 2013 Oct; 14(10):1073-83. PMID: 24013668.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    19. 118 Modulation of Treg and Th17 fate decision by selective ikaros zinc fingers. Cytokine. 2013 Sep 1; 63(3):271. Jennifer Heller, Hilde Schjerven, Ju Qiu, Aileen Lee, Stephen Smale, Liang Zhou. .
      View in: Publisher Site   Mentions:
    20. Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros. Nat Immunol. 2008 Aug; 9(8):927-36. Reynaud D, Demarco IA, Reddy KL, Schjerven H, Bertolino E, Chen Z, Smale ST, Winandy S, Singh H. PMID: 18568028.
      View in: PubMed   Mentions: 120     Fields:    Translation:AnimalsCells
    21. Regulation of B cell fate specification and VH gene rearrangements by Ikaros. The FASEB Journal. 2008 Mar 1; 22:844.7-844.7. Damien REYNAUD, Karen REDDY, Hilde SCHJERVEN, Chauncey SPOONER, Eric BERTOLINO, Stephen T SMALE, Susan WINANDY, Harinder SINGH. .
      View in: Publisher Site   Mentions:
    22. Regulation of the Mucosal IgA System. Mucosal Immune Defense: Immunoglobulin A. 2007 Jan 1; 111-143. Finn-Eirik Johansen, Ranveig Braathen, Else Munthe, Hilde Schjerven, Per Brandtzaeg. .
      View in: Publisher Site   Mentions:
    23. Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses. J Immunol. 2005 Jul 01; 175(1):376-84. Schneeman TA, Bruno ME, Schjerven H, Johansen FE, Chady L, Kaetzel CS. PMID: 15972671.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    24. De novo synthesized RelB mediates TNF-induced up-regulation of the human polymeric Ig receptor. J Immunol. 2004 Aug 01; 173(3):1849-57. Schjerven H, Tran TN, Brandtzaeg P, Johansen FE. PMID: 15265917.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    25. Proinflammatory cytokines upregulate expression of calprotectin (L1 protein, MRP-8/MRP-14) in cultured human keratinocytes. Br J Dermatol. 2003 Sep; 149(3):484-91. Mørk G, Schjerven H, Mangschau L, Søyland E, Brandtzaeg P. PMID: 14510979.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    26. Hepatocyte NF-1 and STAT6 cooperate with additional DNA-binding factors to activate transcription of the human polymeric Ig receptor gene in response to IL-4. J Immunol. 2003 Jun 15; 170(12):6048-56. Schjerven H, Brandtzaeg P, Johansen FE. PMID: 12794133.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    27. A novel NF-kappa B/Rel site in intron 1 cooperates with proximal promoter elements to mediate TNF-alpha-induced transcription of the human polymeric Ig receptor. J Immunol. 2001 Dec 01; 167(11):6412-20. Schjerven H, Brandtzaeg P, Johansen FE. PMID: 11714807.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    28. Mechanism of IL-4-mediated up-regulation of the polymeric Ig receptor: role of STAT6 in cell type-specific delayed transcriptional response. J Immunol. 2000 Oct 01; 165(7):3898-906. Schjerven H, Brandtzaeg P, Johansen FE. PMID: 11034397.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    29. Mannuronan C-5-epimerases and their application for in vitro and in vivo design of new alginates useful in biotechnology. . 1999 Jul; 1(3):262-9. Ertesvåg H, Høidal HK, Schjerven H, Svanem BI, Valla S. PMID: 10937941.
      View in: PubMed   Mentions:
    30. Regulation of the formation and external transport of secretory immunoglobulins. Crit Rev Immunol. 1999; 19(5-6):481-508. Norderhaug IN, Johansen FE, Schjerven H, Brandtzaeg P. PMID: 10647747.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    31. Regulation of the Formation and External Transport of Secretory Immunoglobulins. Critical Reviews in Immunology. 1999 Jan 1; 19(5-6):28. F.-E. Johansen, H. Schjerven, I. N. Norderhaug, P. Brandtzaeg. .
      View in: Publisher Site   Mentions:
    32. E2F-mediated growth regulation requires transcription factor cooperation. J Biol Chem. 1997 Jul 18; 272(29):18367-74. van Ginkel PR, Hsiao KM, Schjerven H, Farnham PJ. PMID: 9218478.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
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