Hilde Schjerven, PhD

Title(s)Associate Professor, Laboratory Medicine
SchoolSchool of Medicine
Phone415-502-3553
ORCID ORCID Icon0000-0001-9287-3375 Additional info
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    Collapse Biography 
    Collapse Awards and Honors
    Oncology Research Fund2018  - 2020Research Award
    Academic Senate, UCSF2020  - 2021Pilot for Junior Investigators
    UCSF Research Evaluation and Allocation Committee (REAC)2021  - 2022Pilot for Junior Investigators
    UCSF Research Evaluation and Allocation Committee (REAC)2023  - 2024Pilot for Established Investigators

    Collapse Overview 
    Collapse Overview
    Member, UCSF Bakar ImmunoX

    Member and Education and Training Liaison, UCSF Helen Diller Family Comprehensive Cancer Center (Cancer Immunology & Immunotherapy Program)

    Member, UCSF Precision Medicine in Rheumatology (PREMIER) Center

    Member, BMS and DSCB Graduate programs

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of medullary thymic epithelial cells and thymic central tolerance by Ikaros
    NIH R01AI165829Dec 12, 2022 - Nov 30, 2027
    Role: Co-Investigator
    Understanding Ikaros molecular functions for targeted therapies of pre-B ALL
    NIH R01CA230618Jul 25, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Role of the transcription factor Ikaros in development of autoimmune disease
    NIH R01AI127709Jun 15, 2018 - May 31, 2023
    Role: Principal Investigator
    Mechanism of Ikaros Tumor Suppression in progenitor B cell leukemia
    NIH R21CA209229Jul 9, 2016 - Jun 30, 2018
    Role: Principal Investigator

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    Collapse Featured Publications
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. ß-catenin engages IKZF factors to control lymphopoiesis. The Journal of Immunology. 2023 May 1; 210(1_Supplement):65.09-65.09. Cosgun CK, Jumaa JH, Robinson RM, Xu XL, Xiao XG, Arce AD, Khanduja KD, Chan CL, Lee LJ, Schjerven SH, Jellusova JJ, Müschen MM. .
      View in: Publisher Site   Mentions:
    2. Targeted engagement of β-catenin-Ikaros complexes in refractory B-cell malignancies. bioRxiv. 2023 Mar 15. Cosgun KN, Jumaa H, Robinson ME, Kistner KM, Xu L, Xiao G, Chan LN, Lee J, Kume K, Leveille E, Fonseca-Arce D, Khanduja D, Ng HL, Feldhahn N, Song J, Chan WC, Chen J, Taketo MM, Kothari S, Davids MS, Schjerven H, Jellusova J, Müschen M. PMID: 36993619; PMCID: PMC10054980.
      View in: PubMed   Mentions:
    3. Ikaros Regulates microRNA Networks in Acute Lymphoblastic Leukemia. Epigenomes. 2022; 6(22):37. Kogut S, Paculova H, Rodriguez P, Boyd J, Richman A, Palaria A, *Schjerven H, *Frietze S. View Publication.
    4. Ikaros Regulates microRNA Networks in Acute Lymphoblastic Leukemia. Epigenomes. 2022 Oct 19; 6(4). Kogut S, Paculova H, Rodriguez P, Boyd J, Richman A, Palaria A, Schjerven H, Frietze S. PMID: 36278683; PMCID: PMC9624360.
      View in: PubMed   Mentions:
    5. ssvQC: an integrated CUT&RUN quality control workflow for histone modifications and transcription factors. BMC Res Notes. 2021 Sep 20; 14(1):366. Boyd J, Rodriguez P, Schjerven H, Frietze S. PMID: 34544495; PMCID: PMC8454122.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    6. Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia. (Review). 2021; 5(22):2683. Rodriguez PD, Paculova H, Kogut S, Heath J, Schjerven H, Frietze S. View Publication.
    7. Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia. Int J Mol Sci. 2021 Mar 07; 22(5). Rodriguez PD, Paculova H, Kogut S, Heath J, Schjerven H, Frietze S. PMID: 33799946; PMCID: PMC7961854.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    8. Abstract PO-62: Overcoming venetoclax resistance in B-cell malignancies by antagonism of stromal TGF-beta-mediated drug resistance. Blood Cancer Discovery. 2020 Nov 1; 1(3_Supplement):po-62-po-62. Park PE, Chen CJ, Moore MA, Mangolini MM, Byod BJ, Schjerven SH, Williamson WJ, Lehner LP, Leitges LM, Egle EA, Schmidt-Supprian SM, Frietze FS, Ringshausen RI. .
      View in: Publisher Site   Mentions:
    9. Ikaros regulates gene expression programs required for proper BCR-activation in mature B cells. The Journal of Immunology. 2020 May 1; 204(1_Supplement):218.2-218.2. Rodriguez RP, Howell HW, Boyd BJ, Frietze FS, Schjerven SH. .
      View in: Publisher Site   Mentions:
    10. Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance. Sci Transl Med. 2020 01 15; 12(526). Park E, Chen J, Moore A, Mangolini M, Santoro A, Boyd JR, Schjerven H, Ecker V, Buchner M, Williamson JC, Lehner PJ, Gasparoli L, Williams O, Bloehdorn J, Stilgenbauer S, Leitges M, Egle A, Schmidt-Supprian M, Frietze S, Ringshausen I. PMID: 31941829; PMCID: PMC7116365.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    11. Ikaros mutations can bypass the requirement for second co-stimulatory signal and lead to break of B-cell tolerance. The Journal of Immunology. 2019 May 1; 202(1_Supplement):179.16-179.16. Schjerven SH, Rodriguez RP, Howell HW, Vestbostad VJ, Frietze FS, Schjerven SH. .
      View in: Publisher Site   Mentions:
    12. Cell circuits between B cell progenitors and IL-7+ mesenchymal progenitor cells control B cell development. J Exp Med. 2018 10 01; 215(10):2586-2599. Fistonich C, Zehentmeier S, Bednarski JJ, Miao R, Schjerven H, Sleckman BP, Pereira JP. PMID: 30158115; PMCID: PMC6170173.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    13. Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2018 06; 558(7711):E5. Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. PMID: 29849140.
      View in: PubMed   Mentions:    Fields:    
    14. Ikaros regulates epigenetic and transcriptional programs in progenitor B cell leukemia. The Journal of Immunology. 2018 May 1; 200(1_Supplement):103.26-103.26. Schjerven SH, Ayongaba AE, Rodriguez RP, Frietze FS. .
      View in: Publisher Site   Mentions:
    15. Ikaros regulates B-cell tolerance. The Journal of Immunology. 2018 May 1; 200(1_Supplement):40.14-40.14. Schjerven SH, Rodriguez RP, Hagen HD, Rasmussen RM, Ayongaba AE, Frietze FS. .
      View in: Publisher Site   Mentions:
    16. A kindred with mutant IKAROS and autoimmunity. J Allergy Clin Immunol. 2018 08; 142(2):699-702.e12. Van Nieuwenhove E, Garcia-Perez JE, Helsen C, Rodriguez PD, van Schouwenburg PA, Dooley J, Schlenner S, van der Burg M, Verhoeyen E, Gijsbers R, Frietze S, Schjerven H, Meyts I, Claessens F, Humblet-Baron S, Wouters C, Liston A. PMID: 29705243; PMCID: PMC6541477.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    17. The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells. Cell Rep. 2017 Nov 21; 21(8):2277-2290. Ye J, Qiu J, Bostick JW, Ueda A, Schjerven H, Li S, Jobin C, Chen ZE, Zhou L. PMID: 29166616; PMCID: PMC5880207.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    18. Abstract 93: Transcriptional control of glucocorticoid responses in leukemia. Experimental and Molecular Therapeutics. 2017 Jul 1; 93-93. Chan CL, Chen CZ, Xiao XG, Lee LJ, Cosgun CK, Geng GH, Cazzaniga CV, Schjerven SH, Dickins DR, Muschen MM. .
      View in: Publisher Site   Mentions:
    19. Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival. Nat Immunol. 2017 06; 18(6):694-704. Katerndahl CDS, Heltemes-Harris LM, Willette MJL, Henzler CM, Frietze S, Yang R, Schjerven H, Silverstein KAT, Ramsey LB, Hubbard G, Wells AD, Kuiper RP, Scheijen B, van Leeuwen FN, Müschen M, Kornblau SM, Farrar MA. PMID: 28369050; PMCID: PMC5540372.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    20. Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2017 02 23; 542(7642):479-483. Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. PMID: 28192788; PMCID: PMC5621518.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    21. Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre-B ALL. J Exp Med. 2017 03 06; 214(3):793-814. Schjerven H, Ayongaba EF, Aghajanirefah A, McLaughlin J, Cheng D, Geng H, Boyd JR, Eggesbø LM, Lindeman I, Heath JL, Park E, Witte ON, Smale ST, Frietze S, Müschen M. PMID: 28190001; PMCID: PMC5339667.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    22. Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway. Immunity. 2016 07 19; 45(1):185-97. Li S, Heller JJ, Bostick JW, Lee A, Schjerven H, Kastner P, Chan S, Chen ZE, Zhou L. PMID: 27438771; PMCID: PMC4959810.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    23. Analysis of Ikaros tumor suppressor function in BCR-ABL1+ pre-B ALL reveals conserved target genes and biological pathways. The Journal of Immunology. 2016 May 1; 196(1_Supplement):122.6-122.6. Schjerven SH, Ayongaba AE, McLaughlin MJ, Cheng CD, Eggesbø EL, Lindeman LI, Park PE, Witte WO, Smale SS, Frietze FS, Muschen MM. .
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    24. Role of the transcription factor Ikaros in development of autoimmune disease. The Journal of Immunology. 2016 May 1; 196(1_Supplement):47.14-47.14. Schjerven SH, Frietze FS, Hai HS, Hermiston HM, Kogan KS, Muschen MM. .
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    25. Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor. Genes Dev. 2015 Sep 01; 29(17):1801-16. Arenzana TL, Schjerven H, Smale ST. PMID: 26314708; PMCID: PMC4573854.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    26. Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia. Blood. 2015 Oct 08; 126(15):1813-22. Song C, Gowda C, Pan X, Ding Y, Tong Y, Tan BH, Wang H, Muthusami S, Ge Z, Sachdev M, Amin SG, Desai D, Gowda K, Gowda R, Robertson GP, Schjerven H, Muschen M, Payne KJ, Dovat S. PMID: 26219304; PMCID: PMC4600018.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    27. Ikaros tumor suppressor function in pre-B ALL: potential role of Ikaros target gene Ctnnd1 (IRM10P.621). The Journal of Immunology. 2015 May 1; 194(1_Supplement):131.19-131.19. Schjerven SH, Eggesbo EL, Lindeman LI, Muschen MM. .
      View in: Publisher Site   Mentions:
    28. STAT5 antagonism of B cell superenhancer networks initiates progenitor B cell leukemia and predicts patient survival (HEM1P.222). The Journal of Immunology. 2015 May 1; 194(1_Supplement):50.5-50.5. Farrar FM, Katerndahl KC, Heltemes Harris HL, Willette WM, Henzler Hc, Yang YR, Silverstein SK, Frietze FS, Schjerven SH, Ramsey RL, Hubbard HG, Muschen MM, Kornblau KS. .
      View in: Publisher Site   Mentions:
    29. Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia. Nat Commun. 2015 Mar 10; 6:6471. Buchner M, Park E, Geng H, Klemm L, Flach J, Passegué E, Schjerven H, Melnick A, Paietta E, Kopanja D, Raychaudhuri P, Müschen M. PMID: 25753524; PMCID: PMC4366523.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    30. PTEN Is Essential for Normal Cytokine Signaling and Oncogenic Transformation of Pre-B Cells. Blood. 2014 Dec 6; 124(21):262-262. Shojaee SS, Cazzaniga CV, Schjerven SH, Buchner BM, Hurtz HC, Geng GH, Hochhaus HA, Cazzaniga CG, Melnick MA, Kornblau KS, Graeber GT, Muschen MM. .
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    31. Erk and Stat5 Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia. Blood. 2014 Dec 6; 124(21):787-787. Seyedmehdi SS, Chen CZ, Buchner BM, Hurtz HC, Geng GH, Schjerven SH, Chan CL, Koeffler KP, Willman WC, Hunger HS, Dovat DS, Paietta PE, Hofmann HW, Melnick MA, Alexander AW, Kornblau KS, Muschen MM. .
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    32. Restriction of IL-22-producing T cell responses and differential regulation of regulatory T cell compartments by zinc finger transcription factor Ikaros. J Immunol. 2014 Oct 15; 193(8):3934-46. Heller JJ, Schjerven H, Li S, Lee A, Qiu J, Chen ZM, Smale ST, Zhou L. PMID: 25194055; PMCID: PMC4185244.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    33. Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros. Nat Immunol. 2013 Oct; 14(10):1073-83. Schjerven H, McLaughlin J, Arenzana TL, Frietze S, Cheng D, Wadsworth SE, Lawson GW, Bensinger SJ, Farnham PJ, Witte ON, Smale ST. PMID: 24013668; PMCID: PMC3800053.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    34. 118 Modulation of Treg and Th17 fate decision by selective ikaros zinc fingers. Cytokine. 2013 Sep 1; 63(3):271. Heller HJ, Schjerven SH, Qiu QJ, Lee LA, Smale SS, Zhou ZL. .
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    35. Selective requirement of Ikaros zinc fingers in Treg and Th17 fate decision. (P1137). The Journal of Immunology. 2013 May 1; 190(1_Supplement):50.11-50.11. Heller HJ, Schjerven SH, Qiu QJ, Lee LA, Smale SS, Zhou ZL. .
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    36. Role of Ikaros in hematopoiesis and tumor suppression: Selective functions of individual zinc fingers within the DNA-binding domain of Ikaros. (42.3). The Journal of Immunology. 2012 May 1; 188(1_Supplement):42.3-42.3. Schjerven SH, Frietze FS, McLaughlin MJ, Cheng CD, Farnham FP, Witte WO, Smale SS. .
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    37. Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros. Nat Immunol. 2008 Aug; 9(8):927-36. Reynaud D, Demarco IA, Reddy KL, Schjerven H, Bertolino E, Chen Z, Smale ST, Winandy S, Singh H. PMID: 18568028; PMCID: PMC2699484.
      View in: PubMed   Mentions: 141     Fields:    Translation:AnimalsCells
    38. Regulation of B cell fate specification and VH gene rearrangements by Ikaros. The FASEB Journal. 2008 Mar 1; 22:844.7-844.7. REYNAUD RD, REDDY RK, SCHJERVEN SH, SPOONER SC, BERTOLINO BE, SMALE SS, WINANDY WS, SINGH SH. .
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    39. Regulation of the Mucosal IgA System. Mucosal Immune Defense: Immunoglobulin A. 2007 Jan 1; 111-143. Johansen JF, Braathen BR, Munthe ME, Schjerven SH, Brandtzaeg BP. .
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    40. Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses. J Immunol. 2005 Jul 01; 175(1):376-84. Schneeman TA, Bruno ME, Schjerven H, Johansen FE, Chady L, Kaetzel CS. PMID: 15972671.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    41. De novo synthesized RelB mediates TNF-induced up-regulation of the human polymeric Ig receptor. J Immunol. 2004 Aug 01; 173(3):1849-57. Schjerven H, Tran TN, Brandtzaeg P, Johansen FE. PMID: 15265917.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    42. Proinflammatory cytokines upregulate expression of calprotectin (L1 protein, MRP-8/MRP-14) in cultured human keratinocytes. Br J Dermatol. 2003 Sep; 149(3):484-91. Mørk G, Schjerven H, Mangschau L, Søyland E, Brandtzaeg P. PMID: 14510979.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    43. Hepatocyte NF-1 and STAT6 cooperate with additional DNA-binding factors to activate transcription of the human polymeric Ig receptor gene in response to IL-4. J Immunol. 2003 Jun 15; 170(12):6048-56. Schjerven H, Brandtzaeg P, Johansen FE. PMID: 12794133.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    44. A novel NF-kappa B/Rel site in intron 1 cooperates with proximal promoter elements to mediate TNF-alpha-induced transcription of the human polymeric Ig receptor. J Immunol. 2001 Dec 01; 167(11):6412-20. Schjerven H, Brandtzaeg P, Johansen FE. PMID: 11714807.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    45. Mechanism of IL-4-mediated up-regulation of the polymeric Ig receptor: role of STAT6 in cell type-specific delayed transcriptional response. J Immunol. 2000 Oct 01; 165(7):3898-906. Schjerven H, Brandtzaeg P, Johansen FE. PMID: 11034397.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    46. Mannuronan C-5-epimerases and their application for in vitro and in vivo design of new alginates useful in biotechnology. Metab Eng. 1999 Jul; 1(3):262-9. Ertesvåg H, Høidal HK, Schjerven H, Svanem BI, Valla S. PMID: 10937941.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    47. Regulation of the formation and external transport of secretory immunoglobulins. Crit Rev Immunol. 1999; 19(5-6):481-508. Norderhaug IN, Johansen FE, Schjerven H, Brandtzaeg P. PMID: 10647747.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    48. Regulation of the Formation and External Transport of Secretory Immunoglobulins. Critical Reviews in Immunology. 1999 Jan 1; 19(5-6):28. Johansen JF, Schjerven SH, Norderhaug NI, Brandtzaeg BP. .
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    49. E2F-mediated growth regulation requires transcription factor cooperation. J Biol Chem. 1997 Jul 18; 272(29):18367-74. van Ginkel PR, Hsiao KM, Schjerven H, Farnham PJ. PMID: 9218478.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
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