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Joe Wiemels, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentEpidemiology & Biostatistics
Address1450 Third St
San Francisco CA 94158
Phone415-514-0577
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    Kenyon CollegeBA1988Biology
    University of California BerkeleyPhD1997Environmental Health Sciences
    Institute of Cancer Research, UKPostdoctoral1999Biology of childhood leukemia

    Collapse Overview 
    Collapse Overview
    The causes of most human cancers are unclear, but appear to be related to miscues in normal tissue developmental pathways, mutations (genetic and epigenetic) in critical genes caused by errors, infection, and chemicals, and a failure of recognition and removal of tumors by the immune system. Dr. Wiemels studies these factors as potential causes of hematopoietic and brain tumors. Large population-based studies of human cancer in the San Francisco Bay Area and State of California form a basis for examining the origin of these cancers, with a focus on future prevention. This type of research is highly collaborative, and Dr. Wiemels works with several epidemiologists, geneticists, clinicians, biologists, and statisticians.


    Collapse Research 
    Collapse Research Activities and Funding
    Brain Tumor Epidemiology Consortium
    NIH/NCI R13CA206359Apr 1, 2016 - Mar 31, 2017
    Role: Principal Investigator
    Genetic Susceptibility to Pediatric Glioma inIndividuals and Diverse populations
    NIH/NCI R01CA194189Sep 9, 2015 - Aug 31, 2020
    Role: Principal Investigator
    Perinatal immune development and risk of childhood acute lymphoblastic leukemia
    NIH/NCI R01CA175737Aug 1, 2014 - Jul 31, 2018
    Role: Principal Investigator
    Impact of low IL-10 levels at birth and leukemia risk
    NIH/NCI R01CA185058Jun 1, 2014 - May 31, 2019
    Role: Principal Investigator
    Varicella virus antigens in glioma etiology and survival
    NIH/NCI U01CA182371Mar 6, 2014 - Jan 31, 2018
    Role: Principal Investigator
    Genome-Wide Association Study of Childhood Leukemia by Hispanic Status
    NIH/NCI R01CA155461Jul 1, 2011 - Apr 30, 2015
    Role: Principal Investigator
    Center for Integrative Research on Childhood Leukemia and the Environment
    NIH P50ES018172Sep 25, 2009 - Jun 30, 2019
    Role: Co-Investigator
    Center for Integrative Research on Childhood Leukemia and the Environment
    NIH P01ES018172Sep 25, 2009 - Jul 31, 2014
    Role: Co-Investigator
    Meningioma: Risk Factors and Quality of Life
    NIH/NCI R01CA109745Jun 26, 2006 - Apr 30, 2011
    Role: Principal Investigator
    BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIA
    NIH/NCI R01CA089032Mar 2, 2001 - Aug 31, 2008
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Wiemels JL, Walsh KM, de Smith AJ, Metayer C, Gonseth S, Hansen HM, Francis SS, Ojha J, Smirnov I, Barcellos L, Xiao X, Morimoto L, McKean-Cowdin R, Wang R, Yu H, Hoh J, DeWan AT, Ma X. GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. Nat Commun. 2018 01 18; 9(1):286. PMID: 29348612.
      View in: PubMed
    2. Wang R, Metayer C, Morimoto L, Wiemels JL, Yang J, DeWan AT, Kang A, Ma X. Parental Age and Risk of Pediatric Cancer in the Offspring: A Population-Based Record-Linkage Study in California. Am J Epidemiol. 2017 Oct 01; 186(7):843-856. PMID: 28535175.
      View in: PubMed
    3. Herceg Z, Ghantous A, Wild CP, Sklias A, Casati L, Duthie SJ, Fry R, Issa JP, Kellermayer R, Koturbash I, Kondo Y, Lepeule J, Lima SCS, Marsit CJ, Rakyan V, Saffery R, Taylor JA, Teschendorff AE, Ushijima T, Vineis P, Walker CL, Waterland RA, Wiemels J, Ambatipudi S, Degli Esposti D, Hernandez-Vargas H. Roadmap for investigating epigenome deregulation and environmental origins of cancer. Int J Cancer. 2018 Mar 01; 142(5):874-882. PMID: 28836271.
      View in: PubMed
    4. Bazyka D, Finch SC, Ilienko IM, Lyaskivska O, Dyagil I, Trotsiuk N, Gudzenko N, Chumak VV, Walsh KM, Wiemels J, Little MP, Zablotska LB. Buccal mucosa micronuclei counts in relation to exposure to low dose-rate radiation from the Chornobyl nuclear accident and other medical and occupational radiation exposures. Environ Health. 2017 06 23; 16(1):70. PMID: 28645274.
      View in: PubMed
    5. Breton CV, Marsit CJ, Faustman E, Nadeau K, Goodrich JM, Dolinoy DC, Herbstman J, Holland N, LaSalle JM, Schmidt R, Yousefi P, Perera F, Joubert BR, Wiemels J, Taylor M, Yang IV, Chen R, Hew KM, Freeland DM, Miller R, Murphy SK. Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group. Environ Health Perspect. 2017 04; 125(4):511-526. PMID: 28362264.
      View in: PubMed
    6. Pekmezci M, Rice T, Molinaro AM, Walsh KM, Decker PA, Hansen H, Sicotte H, Kollmeyer TM, McCoy LS, Sarkar G, Perry A, Giannini C, Tihan T, Berger MS, Wiemels JL, Bracci PM, Eckel-Passow JE, Lachance DH, Clarke J, Taylor JW, Luks T, Wiencke JK, Jenkins RB, Wrensch MR. Adult infiltrating gliomas with WHO 2016 integrated diagnosis: additional prognostic roles of ATRX and TERT. Acta Neuropathol. 2017 Jun; 133(6):1001-1016. PMID: 28255664.
      View in: PubMed
    7. de Smith AJ, Kaur M, Gonseth S, Endicott A, Selvin S, Zhang L, Roy R, Shao X, Hansen HM, Kang AY, Walsh KM, Dahl GV, McKean-Cowdin R, Metayer C, Wiemels JL. Correlates of Prenatal and Early-Life Tobacco Smoke Exposure and Frequency of Common Gene Deletions in Childhood Acute Lymphoblastic Leukemia. Cancer Res. 2017 04 01; 77(7):1674-1683. PMID: 28202519.
      View in: PubMed
    8. Wiencke JK, Koestler DC, Salas LA, Wiemels JL, Roy RP, Hansen HM, Rice T, McCoy LS, Bracci PM, Molinaro AM, Kelsey KT, Wrensch MR, Christensen BC. Immunomethylomic approach to explore the blood neutrophil lymphocyte ratio (NLR) in glioma survival. Clin Epigenetics. 2017; 9:10. PMID: 28184256.
      View in: PubMed
    9. Wang R, Wiemels JL, Metayer C, Morimoto L, Francis SS, Kadan-Lottick N, DeWan AT, Zhang Y, Ma X. Cesarean Section and Risk of Childhood Acute Lymphoblastic Leukemia in a Population-Based, Record-Linkage Study in California. Am J Epidemiol. 2017 Jan 15; 185(2):96-105. PMID: 27986703.
      View in: PubMed
    10. Francis SS, Wallace AD, Wendt GA, Li L, Liu F, Riley LW, Kogan S, Walsh KM, de Smith AJ, Dahl GV, Ma X, Delwart E, Metayer C, Wiemels JL. In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia. Blood. 2017 03 23; 129(12):1680-1684. PMID: 27979823.
      View in: PubMed
    11. Barrington-Trimis JL, Cockburn M, Metayer C, Gauderman WJ, Wiemels J, McKean-Cowdin R. Trends in childhood leukemia incidence over two decades from 1992 to 2013. Int J Cancer. 2017 Mar 01; 140(5):1000-1008. PMID: 27778348.
      View in: PubMed
    12. Endicott AA, Morimoto LM, Kline CN, Wiemels JL, Metayer C, Walsh KM. Perinatal factors associated with clinical presentation of osteosarcoma in children and adolescents. Pediatr Blood Cancer. 2017 Jun; 64(6). PMID: 27860191.
      View in: PubMed
    13. de Smith AJ, Ojha J, Francis SS, Sanders E, Endicott AA, Hansen HM, Smirnov I, Termuhlen AM, Walsh KM, Metayer C, Wiemels JL. Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia. Oncotarget. 2016 Nov 08; 7(45):72733-72745. PMID: 27683039.
      View in: PubMed
    14. Kaur M, de Smith AJ, Selvin S, Zhang L, Cunningham M, Kang MW, Hansen HM, Cooper RM, McKean-Cowdin R, Wiemels JL, Metayer C. Tobacco Smoke and Ras Mutations Among Latino and Non-Latino Children with Acute Lymphoblastic Leukemia. Arch Med Res. 2016 Nov; 47(8):677-683. PMID: 28476195.
      View in: PubMed
    15. Metayer C, Dahl G, Wiemels J, Miller M. Childhood Leukemia: A Preventable Disease. Pediatrics. 2016 Nov; 138(Suppl 1):S45-S55. PMID: 27940977.
      View in: PubMed
    16. Triebwasser C, Wang R, DeWan AT, Metayer C, Morimoto L, Wiemels JL, Kadan-Lottick N, Ma X. Birth weight and risk of paediatric Hodgkin lymphoma: Findings from a population-based record linkage study in California. Eur J Cancer. 2016 12; 69:19-27. PMID: 27814470.
      View in: PubMed
    17. Whitehead TP, Metayer C, Wiemels JL, Singer AW, Miller MD. Childhood Leukemia and Primary Prevention. Curr Probl Pediatr Adolesc Health Care. 2016 Oct; 46(10):317-352. PMID: 27968954.
      View in: PubMed
    18. Johnson KJ, Hainfellner JA, Lau CC, Scheurer ME, Woehrer A, Wiemels J. Immune factors and viral interactions in brain cancer etiology and outcomes, The 2016 Brain Tumor Epidemiology Consortium Meeting report. Clin Neuropathol. 2016 Sep-Oct; 35(5):280-6. PMID: 27546018.
      View in: PubMed
    19. Gonseth S, de Smith AJ, Roy R, Zhou M, Lee ST, Shao X, Ohja J, Wrensch MR, Walsh KM, Metayer C, Wiemels JL. Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates. Epigenetics. 2016 09; 11(9):664-673. PMID: 27403598.
      View in: PubMed
    20. Sapru A, Liu KD, Wiemels J, Hansen H, Pawlikowska L, Poon A, Jorgenson E, Witte JS, Calfee CS, Ware LB, Matthay MA. Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome. Crit Care. 2016 May 23; 20(1):151. PMID: 27215212; PMCID: PMC4876559.
      View in: PubMed, PubMed Central
    21. Ojha J, Codd V, Nelson CP, Samani NJ, Smirnov IV, Madsen NR, Hansen HM, de Smith AJ, Bracci PM, Wiencke JK, Wrensch MR, Wiemels JL, Walsh KM. Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia. Cancer Epidemiol Biomarkers Prev. 2016 07; 25(7):1043-9. PMID: 27197291; PMCID: PMC5008454 [Available on 07/01/17].
      View in: PubMed, PubMed Central
    22. Walsh KM, Whitehead TP, de Smith AJ, Smirnov IV, Park M, Endicott AA, Francis SS, Codd V. Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers. Carcinogenesis. 2016 06; 37(6):576-582. PMID: 27207662.
      View in: PubMed
    23. Hsu LI, Briggs F, Shao X, Metayer C, Wiemels JL, Chokkalingam AP, Barcellos LF. Pathway Analysis of Genome-wide Association Study in Childhood Leukemia among Hispanics. Cancer Epidemiol Biomarkers Prev. 2016 05; 25(5):815-22. PMID: 26941364; PMCID: PMC4873450 [Available on 05/01/17].
      View in: PubMed, PubMed Central
    24. Wiemels J, Ma X. Stressful exit from the womb and risk of childhood leukaemia. Lancet Haematol. 2016 Apr; 3(4):e155-6. PMID: 27063969.
      View in: PubMed
    25. Jiang N, Wiemels RE, Soya A, Whitley R, Held M, Faik A. Composition, Assembly, and Trafficking of a Wheat Xylan Synthase Complex. Plant Physiol. 2016 04; 170(4):1999-2023. PMID: 26917684; PMCID: PMC4825154.
      View in: PubMed, PubMed Central
    26. Carroll RK, Weiss A, Broach WH, Wiemels RE, Mogen AB, Rice KC, Shaw LN. Genome-wide Annotation, Identification, and Global Transcriptomic Analysis of Regulatory or Small RNA Gene Expression in Staphylococcus aureus. MBio. 2016 Feb 09; 7(1):e01990-15. PMID: 26861020; PMCID: PMC4752604.
      View in: PubMed, PubMed Central
    27. Johnson KJ, Scheurer ME, Woehrer A, Wiemels J. Evolving evidence on tumor and germline genetic classification of gliomas: implications for etiology and survival studies. Clin Neuropathol. 2016 Jan-Feb; 35(1):31-8. PMID: 26588027.
      View in: PubMed
    28. Wiemels J. New insights into childhood leukemia etiology. Eur J Epidemiol. 2015 Dec; 30(12):1225-7. PMID: 26686849.
      View in: PubMed
    29. Walsh KM, Codd V, Rice T, Nelson CP, Smirnov IV, McCoy LS, Hansen HM, Elhauge E, Ojha J, Francis SS, Madsen NR, Bracci PM, Pico AR, Molinaro AM, Tihan T, Berger MS, Chang SM, Prados MD, Jenkins RB, Wiemels JL. Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk. Oncotarget. 2015 Dec 15; 6(40):42468-77. PMID: 26646793.
      View in: PubMed
    30. Morimoto LM, McCauley K, Ma X, Wiemels JL, Chokkalingam AP, Metayer C. Birth weight, fetal growth, and risk of pediatric rhabdomyosarcoma: an updated record linkage study in California. Ann Epidemiol. 2016 Feb; 26(2):141-145. PMID: 26795698.
      View in: PubMed
    31. de Smith AJ, Walsh KM, Hansen HM, Endicott AA, Wiencke JK, Metayer C, Wiemels JL. Somatic Mutation Allelic Ratio Test Using ddPCR (SMART-ddPCR): An Accurate Method for Assessment of Preferential Allelic Imbalance in Tumor DNA. PLoS One. 2015; 10(11):e0143343. PMID: 26575185; PMCID: PMC4648491.
      View in: PubMed, PubMed Central
    32. Walsh KM, de Smith AJ, Hansen HM, Smirnov IV, Gonseth S, Endicott AA, Xiao J, Rice T, Fu CH, McCoy LS, Lachance DH, Eckel-Passow JE, Wiencke JK, Jenkins RB, Wrensch MR, Ma X, Metayer C, Wiemels JL. A Heritable Missense Polymorphism in CDKN2A Confers Strong Risk of Childhood Acute Lymphoblastic Leukemia and Is Preferentially Selected during Clonal Evolution. Cancer Res. 2015 Nov 15; 75(22):4884-94. PMID: 26527286.
      View in: PubMed
    33. Lee ST, Wiemels JL. Genome-wide CpG island methylation and intergenic demethylation propensities vary among different tumor sites. Nucleic Acids Res. 2016 Feb 18; 44(3):1105-17. PMID: 26464434; PMCID: PMC4756811.
      View in: PubMed, PubMed Central
    34. Wiemels JL, de Smith AJ, Xiao J, Lee ST, Muench MO, Fomin ME, Zhou M, Hansen HM, Termuhlen A, Metayer C, Walsh KM. A functional polymorphism in the CEBPE gene promoter influences acute lymphoblastic leukemia risk through interaction with the hematopoietic transcription factor Ikaros. Leukemia. 2016 05; 30(5):1194-7. PMID: 26437776.
      View in: PubMed
    35. Rice T, Lachance DH, Molinaro AM, Eckel-Passow JE, Walsh KM, Barnholtz-Sloan J, Ostrom QT, Francis SS, Wiemels J, Jenkins RB, Wiencke JK, Wrensch MR. Understanding inherited genetic risk of adult glioma - a review. Neurooncol Pract. 2016 Mar; 3(1):10-16. PMID: 26941959.
      View in: PubMed
    36. Eckel-Passow JE, Lachance DH, Molinaro AM, Walsh KM, Decker PA, Sicotte H, Pekmezci M, Rice T, Kosel ML, Smirnov IV, Sarkar G, Caron AA, Kollmeyer TM, Praska CE, Chada AR, Halder C, Hansen HM, McCoy LS, Bracci PM, Marshall R, Zheng S, Reis GF, Pico AR, O'Neill BP, Buckner JC, Giannini C, Huse JT, Perry A, Tihan T, Berger MS, Chang SM, Prados MD, Wiemels J, Wiencke JK, Wrensch MR, Jenkins RB. Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors. N Engl J Med. 2015 Jun 25; 372(26):2499-508. PMID: 26061753; PMCID: PMC4489704.
      View in: PubMed, PubMed Central
    37. Kulis M, Merkel A, Heath S, Queirós AC, Schuyler RP, Castellano G, Beekman R, Raineri E, Esteve A, Clot G, Verdaguer-Dot N, Duran-Ferrer M, Russiñol N, Vilarrasa-Blasi R, Ecker S, Pancaldi V, Rico D, Agueda L, Blanc J, Richardson D, Clarke L, Datta A, Pascual M, Agirre X, Prosper F, Alignani D, Paiva B, Caron G, Fest T, Muench MO, Fomin ME, Lee ST, Wiemels JL, Valencia A, Gut M, Flicek P, Stunnenberg HG, Siebert R, Küppers R, Gut IG, Campo E, Martín-Subero JI. Whole-genome fingerprint of the DNA methylome during human B cell differentiation. Nat Genet. 2015 Jul; 47(7):746-56. PMID: 26053498.
      View in: PubMed
    38. Walsh KM, Wiencke JK, Lachance DH, Wiemels JL, Molinaro AM, Eckel-Passow JE, Jenkins RB, Wrensch MR. Telomere maintenance and the etiology of adult glioma. Neuro Oncol. 2015 Nov; 17(11):1445-52. PMID: 26014050; PMCID: PMC4648301 [Available on 11/01/16].
      View in: PubMed, PubMed Central
    39. Barrington-Trimis JL, Cockburn M, Metayer C, Gauderman WJ, Wiemels J, McKean-Cowdin R. Rising rates of acute lymphoblastic leukemia in Hispanic children: trends in incidence from 1992 to 2011. Blood. 2015 May 07; 125(19):3033-4. PMID: 25953979; PMCID: PMC4424421.
      View in: PubMed, PubMed Central
    40. Dahl G, Wiemels J. What causes leukemia? Pediatr Blood Cancer. 2015 Jul; 62(7):1123-4. PMID: 25894591.
      View in: PubMed
    41. Gonseth S, Nusslé S, Bovet P, Panese F, Wiemels JL. Excess winter deaths caused by cardiovascular diseases are associated with both mild winter temperature and socio-economic inequalities in the U.S. Int J Cardiol. 2015; 187:642-4. PMID: 25863741.
      View in: PubMed
    42. Hsu LI, Chokkalingam AP, Briggs FB, Walsh K, Crouse V, Fu C, Metayer C, Wiemels JL, Barcellos LF, Buffler PA. Association of genetic variation in IKZF1, ARID5B, and CEBPE and surrogates for early-life infections with the risk of acute lymphoblastic leukemia in Hispanic children. Cancer Causes Control. 2015 Apr; 26(4):609-19. PMID: 25761407; PMCID: PMC4504234.
      View in: PubMed, PubMed Central
    43. Lee ST, Muench MO, Fomin ME, Xiao J, Zhou M, de Smith A, Martín-Subero JI, Heath S, Houseman EA, Roy R, Wrensch M, Wiencke J, Metayer C, Wiemels JL. Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures. Nucleic Acids Res. 2015 Mar 11; 43(5):2590-602. PMID: 25690899; PMCID: PMC4357708.
      View in: PubMed, PubMed Central
    44. Zhou M, Bracci PM, McCoy LS, Hsuang G, Wiemels JL, Rice T, Zheng S, Kelsey KT, Wrensch MR, Wiencke JK. Serum macrophage-derived chemokine/CCL22 levels are associated with glioma risk, CD4 T cell lymphopenia and survival time. Int J Cancer. 2015 Aug 15; 137(4):826-36. PMID: 25604093.
      View in: PubMed
    45. Claus EB, Walsh KM, Wiencke JK, Molinaro AM, Wiemels JL, Schildkraut JM, Bondy ML, Berger M, Jenkins R, Wrensch M. Survival and low-grade glioma: the emergence of genetic information. Neurosurg Focus. 2015 Jan; 38(1):E6. PMID: 25552286; PMCID: PMC4361022.
      View in: PubMed, PubMed Central
    46. Woehrer A, Lau CC, Prayer D, Bauchet L, Rosenfeld M, Capper D, Fisher PG, Kool M, Müller M, Kros JM, Kruchko C, Wiemels J, Wrensch M, Danysh HE, Zouaoui S, Heck JE, Johnson KJ, Qi X, O'Neill BP, Afzal S, Scheurer ME, Bainbridge MN, Nousome D, Bahassi el M, Hainfellner JA, Barnholtz-Sloan JS. Brain Tumor Epidemiology - A Hub within Multidisciplinary Neuro-oncology. Report on the 15th Brain Tumor Epidemiology Consortium (BTEC) Annual Meeting, Vienna, 2014. Clin Neuropathol. 2015 Jan-Feb; 34(1):40-6. PMID: 25518914; PMCID: PMC4317580.
      View in: PubMed, PubMed Central
    47. Gonseth S, Roy R, Houseman EA, de Smith AJ, Zhou M, Lee ST, Nusslé S, Singer AW, Wrensch MR, Metayer C, Wiemels JL. Periconceptional folate consumption is associated with neonatal DNA methylation modifications in neural crest regulatory and cancer development genes. Epigenetics. 2015; 10(12):1166-76. PMID: 26646725; PMCID: PMC4844202 [Available on 12/08/16].
      View in: PubMed, PubMed Central
    48. Zhang X, Xue F, Liu H, Zhu D, Peng B, Wiemels JL, Yang X. Integrative Bayesian variable selection with gene-based informative priors for genome-wide association studies. BMC Genet. 2014 Dec 10; 15:130. PMID: 25491445; PMCID: PMC4275962.
      View in: PubMed, PubMed Central
    49. Zhang L, Samad A, Pombo-de-Oliveira MS, Scelo G, Smith MT, Feusner J, Wiemels JL, Metayer C. Global characteristics of childhood acute promyelocytic leukemia. Blood Rev. 2015 Mar; 29(2):101-25. PMID: 25445717; PMCID: PMC4379131.
      View in: PubMed, PubMed Central
    50. Walsh KM, Codd V, Smirnov IV, Rice T, Decker PA, Hansen HM, Kollmeyer T, Kosel ML, Molinaro AM, McCoy LS, Bracci PM, Cabriga BS, Pekmezci M, Zheng S, Wiemels JL, Pico AR, Tihan T, Berger MS, Chang SM, Prados MD, Lachance DH, O'Neill BP, Sicotte H, Eckel-Passow JE. Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nat Genet. 2014 Jul; 46(7):731-5. PMID: 24908248; PMCID: PMC4074274.
      View in: PubMed, PubMed Central
    51. Walsh KM, de Smith AJ, Welch TC, Smirnov I, Cunningham MJ, Ma X, Chokkalingam AP, Dahl GV, Roberts W, Barcellos LF, Buffler PA, Metayer C, Wiemels JL. Genomic ancestry and somatic alterations correlate with age at diagnosis in Hispanic children with B-cell acute lymphoblastic leukemia. Am J Hematol. 2014 Jul; 89(7):721-5. PMID: 24753091; PMCID: PMC4069235.
      View in: PubMed, PubMed Central
    52. Olson SH, Hsu M, Wiemels JL, Bracci PM, Zhou M, Patoka J, Reisacher WR, Wang J, Kurtz RC, Silverman DT, Stolzenberg-Solomon RZ. Serum immunoglobulin e and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiol Biomarkers Prev. 2014 Jul; 23(7):1414-20. PMID: 24718282; PMCID: PMC4120187.
      View in: PubMed, PubMed Central
    53. Francis SS, Selvin S, Metayer C, Wallace AD, Crouse V, Moore TB, Wiemels JL, Buffler PA. Mode of delivery and risk of childhood leukemia. Cancer Epidemiol Biomarkers Prev. 2014 May; 23(5):876-81. PMID: 24618997.
      View in: PubMed
    54. Xiao J, Lee ST, Xiao Y, Ma X, Houseman EA, Hsu LI, Roy R, Wrensch M, de Smith AJ, Chokkalingam A, Buffler P, Wiencke JK, Wiemels JL. PTPRG inhibition by DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia. Int J Cancer. 2014 Sep 01; 135(5):1101-9. PMID: 24496747; PMCID: PMC4776754.
      View in: PubMed, PubMed Central
    55. de Smith AJ, Walsh KM, Ladner MB, Zhang S, Xiao C, Cohen F, Moore TB, Chokkalingam AP, Metayer C, Buffler PA, Trachtenberg EA, Wiemels JL. The role of KIR genes and their cognate HLA class I ligands in childhood acute lymphoblastic leukemia. Blood. 2014 Apr 17; 123(16):2497-503. PMID: 24518758; PMCID: PMC3990912.
      View in: PubMed, PubMed Central
    56. Diakos C, Xiao Y, Zheng S, Kager L, Dworzak M, Wiemels JL. Direct and indirect targets of the E2A-PBX1 leukemia-specific fusion protein. PLoS One. 2014; 9(2):e87602. PMID: 24503810; PMCID: PMC3913655.
      View in: PubMed, PubMed Central
    57. Schildkraut JM, Calvocoressi L, Wang F, Wrensch M, Bondy ML, Wiemels JL, Claus EB. Endogenous and exogenous hormone exposure and the risk of meningioma in men. J Neurosurg. 2014 Apr; 120(4):820-6. PMID: 24484233; PMCID: PMC4386752.
      View in: PubMed, PubMed Central
    58. Goodman M, LaKind JS, Fagliano JA, Lash TL, Wiemels JL, Winn DM, Patel C, Van Eenwyk J, Kohler BA, Schisterman EF, Albert P, Mattison DR. Cancer cluster investigations: review of the past and proposals for the future. Int J Environ Res Public Health. 2014 Jan 28; 11(2):1479-99. PMID: 24477211; PMCID: PMC3945549.
      View in: PubMed, PubMed Central
    59. Walsh KM, de Smith AJ, Chokkalingam AP, Metayer C, Roberts W, Barcellos LF, Wiemels JL, Buffler PA. GATA3 risk alleles are associated with ancestral components in Hispanic children with ALL. Blood. 2013 Nov 07; 122(19):3385-7. PMID: 24203929; PMCID: PMC3821727.
      View in: PubMed, PubMed Central
    60. Lee ST, Bracci P, Zhou M, Rice T, Wiencke J, Wrensch M, Wiemels J. Interaction of allergy history and antibodies to specific varicella-zoster virus proteins on glioma risk. Int J Cancer. 2014 May 01; 134(9):2199-210. PMID: 24127236; PMCID: PMC3951480.
      View in: PubMed, PubMed Central
    61. Urayama KY, Chokkalingam AP, Metayer C, Hansen H, May S, Ramsay P, Wiemels JL, Wiencke JK, Trachtenberg E, Thompson P, Ishida Y, Brennan P, Jolly KW, Termuhlen AM, Taylor M, Barcellos LF, Buffler PA. SNP association mapping across the extended major histocompatibility complex and risk of B-cell precursor acute lymphoblastic leukemia in children. PLoS One. 2013; 8(8):e72557. PMID: 23991122; PMCID: PMC3749982.
      View in: PubMed, PubMed Central
    62. Metayer C, Zhang L, Wiemels JL, Bartley K, Schiffman J, Ma X, Aldrich MC, Chang JS, Selvin S, Fu CH, Ducore J, Smith MT, Buffler PA. Tobacco smoke exposure and the risk of childhood acute lymphoblastic and myeloid leukemias by cytogenetic subtype. Cancer Epidemiol Biomarkers Prev. 2013 Sep; 22(9):1600-11. PMID: 23853208; PMCID: PMC3769478.
      View in: PubMed, PubMed Central
    63. Chokkalingam AP, Hsu LI, Metayer C, Hansen HM, Month SR, Barcellos LF, Wiemels JL, Buffler PA. Genetic variants in ARID5B and CEBPE are childhood ALL susceptibility loci in Hispanics. Cancer Causes Control. 2013 Oct; 24(10):1789-95. PMID: 23836053; PMCID: PMC3771434.
      View in: PubMed, PubMed Central
    64. Walsh KM, de Smith AJ, Chokkalingam AP, Metayer C, Dahl GV, Hsu LI, Barcellos LF, Wiemels JL, Buffler PA. Novel childhood ALL susceptibility locus BMI1-PIP4K2A is specifically associated with the hyperdiploid subtype. Blood. 2013 Jun 06; 121(23):4808-9. PMID: 23744494; PMCID: PMC3674678.
      View in: PubMed, PubMed Central
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    76. Paper JM, Scott-Craig JS, Cavalier D, Faik A, Wiemels RE, Borrusch MS, Bongers M, Walton JD. a-Fucosidases with different substrate specificities from two species of Fusarium. Appl Microbiol Biotechnol. 2013 Jun; 97(12):5371-80. PMID: 23011349.
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    92. Joannides M, Mays AN, Mistry AR, Hasan SK, Reiter A, Wiemels JL, Felix CA, Coco FL, Osheroff N, Solomon E, Grimwade D. Molecular pathogenesis of secondary acute promyelocytic leukemia. Mediterr J Hematol Infect Dis. 2011; 3(1):e2011045. PMID: 22110895; PMCID: PMC3219647.
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    107. Wiemels J, Wrensch M, Claus EB. Epidemiology and etiology of meningioma. J Neurooncol. 2010 Sep; 99(3):307-14. PMID: 20821343; PMCID: PMC2945461.
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    109. Marsit CJ, Houseman EA, Christensen BC, Gagne L, Wrensch MR, Nelson HH, Wiemels J, Zheng S, Wiencke JK, Andrew AS, Schned AR, Karagas MR, Kelsey KT. Identification of methylated genes associated with aggressive bladder cancer. PLoS One. 2010 Aug 23; 5(8):e12334. PMID: 20808801; PMCID: PMC2925945.
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    126. Wiemels J, Kang M, Greaves M. Backtracking of leukemic clones to birth. Methods Mol Biol. 2009; 538:7-27. PMID: 19277581.
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    128. Ma X, Urayama K, Chang J, Wiemels JL, Buffler PA. Infection and pediatric acute lymphoblastic leukemia. Blood Cells Mol Dis. 2009 Mar-Apr; 42(2):117-20. PMID: 19064328; PMCID: PMC2834409.
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    129. Chang JS, Wiemels JL, Buffler PA. Allergies and childhood leukemia. Blood Cells Mol Dis. 2009 Mar-Apr; 42(2):99-104. PMID: 19049852.
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    130. Wiemels JL, Hofmann J, Kang M, Selzer R, Green R, Zhou M, Zhong S, Zhang L, Smith MT, Marsit C, Loh M, Buffler P, Yeh RF. Chromosome 12p deletions in TEL-AML1 childhood acute lymphoblastic leukemia are associated with retrotransposon elements and occur postnatally. Cancer Res. 2008 Dec 01; 68(23):9935-44. PMID: 19047175; PMCID: PMC2597307.
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    131. Walz C, Score J, Mix J, Cilloni D, Roche-Lestienne C, Yeh RF, Wiemels JL, Ottaviani E, Erben P, Hochhaus A, Baccarani M, Grimwade D, Preudhomme C, Apperley J, Martinelli G, Saglio G, Cross NC, Reiter A. The molecular anatomy of the FIP1L1-PDGFRA fusion gene. Leukemia. 2009 Feb; 23(2):271-8. PMID: 18987651.
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    132. Pico AR, Smirnov IV, Chang JS, Yeh RF, Wiemels JL, Wiencke JK, Tihan T, Conklin BR, Wrensch M. SNPLogic: an interactive single nucleotide polymorphism selection, annotation, and prioritization system. Nucleic Acids Res. 2009 Jan; 37(Database issue):D803-9. PMID: 18984625; PMCID: PMC2686434.
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    133. Vasconcelos GM, Kang M, Pombo-de-Oliveira MS, Schiffman JD, Lorey F, Buffler P, Wiemels JL. Adenovirus detection in Guthrie cards from paediatric leukaemia cases and controls. Br J Cancer. 2008 Nov 18; 99(10):1668-72. PMID: 19002185; PMCID: PMC2584954.
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    134. Guha N, Chang JS, Chokkalingam AP, Wiemels JL, Smith MT, Buffler PA. NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysis. Am J Epidemiol. 2008 Dec 01; 168(11):1221-32. PMID: 18945694; PMCID: PMC2727266.
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    135. Scélo G, Metayer C, Zhang L, Wiemels JL, Aldrich MC, Selvin S, Month S, Smith MT, Buffler PA. Household exposure to paint and petroleum solvents, chromosomal translocations, and the risk of childhood leukemia. Environ Health Perspect. 2009 Jan; 117(1):133-9. PMID: 19165400; PMCID: PMC2627857.
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    136. Bondy ML, Scheurer ME, Malmer B, Barnholtz-Sloan JS, Davis FG, Il'yasova D, Kruchko C, McCarthy BJ, Rajaraman P, Schwartzbaum JA, Sadetzki S, Schlehofer B, Tihan T, Wiemels JL, Wrensch M, Buffler PA. Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium. Cancer. 2008 Oct 01; 113(7 Suppl):1953-68. PMID: 18798534; PMCID: PMC2861559.
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    137. Houseman EA, Christensen BC, Yeh RF, Marsit CJ, Karagas MR, Wrensch M, Nelson HH, Wiemels J, Zheng S, Wiencke JK, Kelsey KT. Model-based clustering of DNA methylation array data: a recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributions. BMC Bioinformatics. 2008 Sep 09; 9:365. PMID: 18782434; PMCID: PMC2553421.
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    138. Chang JS, Yeh RF, Wiencke JK, Wiemels JL, Smirnov I, Pico AR, Tihan T, Patoka J, Miike R, Sison JD, Rice T, Wrensch MR. Pathway analysis of single-nucleotide polymorphisms potentially associated with glioblastoma multiforme susceptibility using random forests. Cancer Epidemiol Biomarkers Prev. 2008 Jun; 17(6):1368-73. PMID: 18559551.
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    139. Wiemels J. Chromosomal translocations in childhood leukemia: natural history, mechanisms, and epidemiology. J Natl Cancer Inst Monogr. 2008; (39):87-90. PMID: 18648011.
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    140. Fisher JL, Schwartzbaum JA, Wrensch M, Wiemels JL. Epidemiology of brain tumors. Neurol Clin. 2007 Nov; 25(4):867-90, vii. PMID: 17964019.
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    141. Hansen HM, Wiemels JL, Wrensch M, Wiencke JK. DNA quantification of whole genome amplified samples for genotyping on a multiplexed bead array platform. Cancer Epidemiol Biomarkers Prev. 2007 Aug; 16(8):1686-90. PMID: 17684147.
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    142. Claus EB, Black PM, Bondy ML, Calvocoressi L, Schildkraut JM, Wiemels JL, Wrensch M. Exogenous hormone use and meningioma risk: what do we tell our patients? Cancer. 2007 Aug 01; 110(3):471-6. PMID: 17580362.
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    143. Wiemels JL, Wiencke JK, Kelsey KT, Moghadassi M, Rice T, Urayama KY, Miike R, Wrensch M. Allergy-related polymorphisms influence glioma status and serum IgE levels. Cancer Epidemiol Biomarkers Prev. 2007 Jun; 16(6):1229-35. PMID: 17548690.
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    144. Urayama KY, Wiencke JK, Buffler PA, Chokkalingam AP, Metayer C, Wiemels JL. MDR1 gene variants, indoor insecticide exposure, and the risk of childhood acute lymphoblastic leukemia. Cancer Epidemiol Biomarkers Prev. 2007 Jun; 16(6):1172-7. PMID: 17548681.
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    145. Busch K, Keller T, Fuchs U, Yeh RF, Harbott J, Klose I, Wiemels J, Novosel A, Reiter A, Borkhardt A. Identification of two distinct MYC breakpoint clusters and their association with various IGH breakpoint regions in the t(8;14) translocations in sporadic Burkitt-lymphoma. Leukemia. 2007 Aug; 21(8):1739-51. PMID: 17541401.
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    146. Wrensch M, McMillan A, Wiencke J, Wiemels J, Kelsey K, Patoka J, Jones H, Carlton V, Miike R, Sison J, Moghadassi M, Prados M. Nonsynonymous coding single-nucleotide polymorphisms spanning the genome in relation to glioblastoma survival and age at diagnosis. Clin Cancer Res. 2007 Jan 01; 13(1):197-205. PMID: 17200355.
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    147. Paynter RA, Skibola DR, Skibola CF, Buffler PA, Wiemels JL, Smith MT. Accuracy of multiplexed Illumina platform-based single-nucleotide polymorphism genotyping compared between genomic and whole genome amplified DNA collected from multiple sources. Cancer Epidemiol Biomarkers Prev. 2006 Dec; 15(12):2533-6. PMID: 17164381.
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    148. Sapru A, Wiemels JL, Witte JS, Ware LB, Matthay MA. Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathways. Intensive Care Med. 2006 Sep; 32(9):1293-303. PMID: 16770611.
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    149. Wrensch M, Wiencke JK, Wiemels J, Miike R, Patoka J, Moghadassi M, McMillan A, Kelsey KT, Aldape K, Lamborn KR, Parsa AT, Sison JD, Prados MD. Serum IgE, tumor epidermal growth factor receptor expression, and inherited polymorphisms associated with glioma survival. Cancer Res. 2006 Apr 15; 66(8):4531-41. PMID: 16618782.
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    150. Aldrich MC, Zhang L, Wiemels JL, Ma X, Loh ML, Metayer C, Selvin S, Feusner J, Smith MT, Buffler PA. Cytogenetics of Hispanic and White children with acute lymphoblastic leukemia in California. Cancer Epidemiol Biomarkers Prev. 2006 Mar; 15(3):578-81. PMID: 16537719.
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    151. Claus EB, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M, Black PM. Epidemiology of intracranial meningioma. Neurosurgery. 2005 Dec; 57(6):1088-95; discussion 1088-95. PMID: 16331155.
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    152. Wrensch M, Kelsey KT, Liu M, Miike R, Moghadassi M, Sison JD, Aldape K, McMillan A, Wiemels J, Wiencke JK. ERCC1 and ERCC2 polymorphisms and adult glioma. Neuro Oncol. 2005 Oct; 7(4):495-507. PMID: 16212814; PMCID: PMC1871723.
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    153. Kwan ML, Buffler PA, Wiemels JL, Metayer C, Selvin S, Ducore JM, Block G. Breastfeeding patterns and risk of childhood acute lymphoblastic leukaemia. Br J Cancer. 2005 Aug 08; 93(3):379-84. PMID: 16052219; PMCID: PMC2361562.
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    154. Smith MT, McHale CM, Wiemels JL, Zhang L, Wiencke JK, Zheng S, Gunn L, Skibola CF, Ma X, Buffler PA. Molecular biomarkers for the study of childhood leukemia. Toxicol Appl Pharmacol. 2005 Aug 07; 206(2):237-45. PMID: 15967214.
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    155. Ma X, Buffler PA, Wiemels JL, Selvin S, Metayer C, Loh M, Does MB, Wiencke JK. Ethnic difference in daycare attendance, early infections, and risk of childhood acute lymphoblastic leukemia. Cancer Epidemiol Biomarkers Prev. 2005 Aug; 14(8):1928-34. PMID: 16103439.
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    156. Wiencke JK, Aldape K, McMillan A, Wiemels J, Moghadassi M, Miike R, Kelsey KT, Patoka J, Long J, Wrensch M. Molecular features of adult glioma associated with patient race/ethnicity, age, and a polymorphism in O6-methylguanine-DNA-methyltransferase. Cancer Epidemiol Biomarkers Prev. 2005 Jul; 14(7):1774-83. PMID: 16030116.
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    157. Wrensch M, Weinberg A, Wiencke J, Miike R, Sison J, Wiemels J, Barger G, DeLorenze G, Aldape K, Kelsey K. History of chickenpox and shingles and prevalence of antibodies to varicella-zoster virus and three other herpesviruses among adults with glioma and controls. Am J Epidemiol. 2005 May 15; 161(10):929-38. PMID: 15870157.
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    158. Mistry AR, Felix CA, Whitmarsh RJ, Mason A, Reiter A, Cassinat B, Parry A, Walz C, Wiemels JL, Segal MR, Adès L, Blair IA, Osheroff N, Peniket AJ, Lafage-Pochitaloff M, Cross NC, Chomienne C, Solomon E, Fenaux P, Grimwade D. DNA topoisomerase II in therapy-related acute promyelocytic leukemia. N Engl J Med. 2005 Apr 14; 352(15):1529-38. PMID: 15829534.
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    159. Wiemels JL, Zhang Y, Chang J, Zheng S, Metayer C, Zhang L, Smith MT, Ma X, Selvin S, Buffler PA, Wiencke JK. RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia. Leukemia. 2005 Mar; 19(3):415-9. PMID: 15674422.
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    160. Wiemels JL, Wiencke JK, Patoka J, Moghadassi M, Chew T, McMillan A, Miike R, Barger G, Wrensch M. Reduced immunoglobulin E and allergy among adults with glioma compared with controls. Cancer Res. 2004 Nov 15; 64(22):8468-73. PMID: 15548720.
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    161. Maia AT, Koechling J, Corbett R, Metzler M, Wiemels JL, Greaves M. Protracted postnatal natural histories in childhood leukemia. Genes Chromosomes Cancer. 2004 Apr; 39(4):335-40. PMID: 14978794.
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    162. Zheng S, Ma X, Zhang L, Gunn L, Smith MT, Wiemels JL, Leung K, Buffler PA, Wiencke JK. Hypermethylation of the 5' CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemia. Cancer Res. 2004 Mar 15; 64(6):2000-6. PMID: 15026336.
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    163. Greaves MF, Wiemels J. Origins of chromosome translocations in childhood leukaemia. Nat Rev Cancer. 2003 Sep; 3(9):639-49. PMID: 12951583.
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    164. Greaves MF, Maia AT, Wiemels JL, Ford AM. Leukemia in twins: lessons in natural history. Blood. 2003 Oct 01; 102(7):2321-33. PMID: 12791663.
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    165. McHale CM, Wiemels JL, Zhang L, Ma X, Buffler PA, Feusner J, Matthay K, Dahl G, Smith MT. Prenatal origin of childhood acute myeloid leukemias harboring chromosomal rearrangements t(15;17) and inv(16). Blood. 2003 Jun 01; 101(11):4640-1. PMID: 12756163.
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    166. McHale CM, Wiemels JL, Zhang L, Ma X, Buffler PA, Guo W, Loh ML, Smith MT. Prenatal origin of TEL-AML1-positive acute lymphoblastic leukemia in children born in California. Genes Chromosomes Cancer. 2003 May; 37(1):36-43. PMID: 12661004.
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    167. Pine SR, Moy FH, Wiemels JL, Gill RK, Levendoglu-Tugal O, Ozkaynak MF, Sandoval C, Jayabose S. Real-time quantitative PCR: standardized detection of minimal residual disease in pediatric acute lymphoblastic leukemia. Polymerase chain reaction. J Pediatr Hematol Oncol. 2003 Feb; 25(2):103-8. PMID: 12571459.
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    168. Reiter A, Saussele S, Grimwade D, Wiemels JL, Segal MR, Lafage-Pochitaloff M, Walz C, Weisser A, Hochhaus A, Willer A, Reichert A, Büchner T, Lengfelder E, Hehlmann R, Cross NC. Genomic anatomy of the specific reciprocal translocation t(15;17) in acute promyelocytic leukemia. Genes Chromosomes Cancer. 2003 Feb; 36(2):175-88. PMID: 12508246.
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    169. Pine SR, Wiemels JL, Jayabose S, Sandoval C. TEL-AML1 fusion precedes differentiation to pre-B cells in childhood acute lymphoblastic leukemia. Leuk Res. 2003 Feb; 27(2):155-64. PMID: 12526921.
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    170. Wiemels JL, Leonard BC, Wang Y, Segal MR, Hunger SP, Smith MT, Crouse V, Ma X, Buffler PA, Pine SR. Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):15101-6. PMID: 12415113; PMCID: PMC137550.
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    171. Wiemels JL, Xiao Z, Buffler PA, Maia AT, Ma X, Dicks BM, Smith MT, Zhang L, Feusner J, Wiencke J, Pritchard-Jones K, Kempski H, Greaves M. In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia. Blood. 2002 May 15; 99(10):3801-5. PMID: 11986239.
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    172. Ma X, Buffler PA, Selvin S, Matthay KK, Wiencke JK, Wiemels JL, Reynolds P. Daycare attendance and risk of childhood acute lymphoblastic leukaemia. Br J Cancer. 2002 May 06; 86(9):1419-24. PMID: 11986774; PMCID: PMC2375371.
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    173. Wiemels JL, Wiencke JK, Sison JD, Miike R, McMillan A, Wrensch M. History of allergies among adults with glioma and controls. Int J Cancer. 2002 Apr 01; 98(4):609-15. PMID: 11920623.
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    174. Xiao Z, Greaves MF, Buffler P, Smith MT, Segal MR, Dicks BM, Wiencke JK, Wiemels JL. Molecular characterization of genomic AML1-ETO fusions in childhood leukemia. Leukemia. 2001 Dec; 15(12):1906-13. PMID: 11753612.
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    175. Hayes RB, Zhang L, Swenberg JA, Yin SN, Xi L, Wiencke J, Bechtold WE, Yao M, Rothman N, Haas R, O'Neill JP, Wiemels J, Dosemeci M, Li G, Smith MT. Markers for carcinogenicity among butadiene-polymer workers in China. Chem Biol Interact. 2001 Jun 01; 135-136:455-64. PMID: 11397406.
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    176. Alexander FE, Patheal SL, Biondi A, Brandalise S, Cabrera ME, Chan LC, Chen Z, Cimino G, Cordoba JC, Gu LJ, Hussein H, Ishii E, Kamel AM, Labra S, Magalhães IQ, Mizutani S, Petridou E, de Oliveira MP, Yuen P, Wiemels JL, Greaves MF. Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion. Cancer Res. 2001 Mar 15; 61(6):2542-6. PMID: 11289128.
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    177. Wiemels JL, Smith RN, Taylor GM, Eden OB, Alexander FE, Greaves MF. Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia. Proc Natl Acad Sci U S A. 2001 Mar 27; 98(7):4004-9. PMID: 11274424; PMCID: PMC31169.
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    178. Smith MT, Wang Y, Kane E, Rollinson S, Wiemels JL, Roman E, Roddam P, Cartwright R, Morgan G. Low NAD(P)H:quinone oxidoreductase 1 activity is associated with increased risk of acute leukemia in adults. Blood. 2001 Mar 01; 97(5):1422-6. PMID: 11222389.
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    179. Wiemels JL, Alexander FE, Cazzaniga G, Biondi A, Mayer SP, Greaves M. Microclustering of TEL-AML1 translocation breakpoints in childhood acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2000 Nov; 29(3):219-28. PMID: 10992297.
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    180. Naoe T, Takeyama K, Yokozawa T, Kiyoi H, Seto M, Uike N, Ino T, Utsunomiya A, Maruta A, Jin-nai I, Kamada N, Kubota Y, Nakamura H, Shimazaki C, Horiike S, Kodera Y, Saito H, Ueda R, Wiemels J, Ohno R. Analysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/ myelodysplastic syndrome and de novo acute myeloid leukemia. Clin Cancer Res. 2000 Oct; 6(10):4091-5. PMID: 11051261.
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    181. Hayes RB, Zhang L, Yin S, Swenberg JA, Xi L, Wiencke J, Bechtold WE, Yao M, Rothman N, Haas R, O'Neill JP, Zhang D, Wiemels J, Dosemeci M, Li G, Smith MT. Genotoxic markers among butadiene polymer workers in China. Carcinogenesis. 2000 Jan; 21(1):55-62. PMID: 10607734.
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    182. Wiemels JL, Cazzaniga G, Daniotti M, Eden OB, Addison GM, Masera G, Saha V, Biondi A, Greaves MF. Prenatal origin of acute lymphoblastic leukaemia in children. Lancet. 1999 Oct 30; 354(9189):1499-503. PMID: 10551495.
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    183. Wiemels JL, Pagnamenta A, Taylor GM, Eden OB, Alexander FE, Greaves MF. A lack of a functional NAD(P)H:quinone oxidoreductase allele is selectively associated with pediatric leukemias that have MLL fusions. United Kingdom Childhood Cancer Study Investigators. Cancer Res. 1999 Aug 15; 59(16):4095-9. PMID: 10463613.
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    184. Wiemels JL, Greaves M. Structure and possible mechanisms of TEL-AML1 gene fusions in childhood acute lymphoblastic leukemia. Cancer Res. 1999 Aug 15; 59(16):4075-82. PMID: 10463610.
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    185. Wiemels JL, Ford AM, Van Wering ER, Postma A, Greaves M. Protracted and variable latency of acute lymphoblastic leukemia after TEL-AML1 gene fusion in utero. Blood. 1999 Aug 01; 94(3):1057-62. PMID: 10419898.
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    186. Larson RA, Wang Y, Banerjee M, Wiemels J, Hartford C, Le Beau MM, Smith MT. Prevalence of the inactivating 609C-->T polymorphism in the NAD(P)H:quinone oxidoreductase (NQO1) gene in patients with primary and therapy-related myeloid leukemia. Blood. 1999 Jul 15; 94(2):803-7. PMID: 10397748.
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    187. Wiemels J, Wiencke JK, Varykoni A, Smith MT. Modulation of the toxicity and macromolecular binding of benzene metabolites by NAD(P)H:Quinone oxidoreductase in transfected HL-60 cells. Chem Res Toxicol. 1999 Jun; 12(6):467-75. PMID: 10368308.
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    188. Wiemels J, Smith MT. Enhancement of myeloid cell growth by benzene metabolites via the production of active oxygen species. Free Radic Res. 1999 Feb; 30(2):93-103. PMID: 10193577.
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    189. Smith MT, Zhang L, Wang Y, Hayes RB, Li G, Wiemels J, Dosemeci M, Titenko-Holland N, Xi L, Kolachana P, Yin S, Rothman N. Increased translocations and aneusomy in chromosomes 8 and 21 among workers exposed to benzene. Cancer Res. 1998 May 15; 58(10):2176-81. PMID: 9605763.
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    190. Rothman N, Smith MT, Hayes RB, Li GL, Irons RD, Dosemeci M, Haas R, Stillman WS, Linet M, Xi LQ, Bechtold WE, Wiemels J, Campleman S, Zhang L, Quintana PJ, Titenko-Holland N, Wang YZ, Lu W, Kolachana P, Meyer KB, Yin S. An epidemiologic study of early biologic effects of benzene in Chinese workers. Environ Health Perspect. 1996 Dec; 104 Suppl 6:1365-70. PMID: 9118921; PMCID: PMC1469765.
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    191. Hayes RB, Xi L, Bechtold WE, Rothman N, Yao M, Henderson R, Zhang L, Smith MT, Zhang D, Wiemels J, Dosemeci M, Yin S, O'Neill JP. hprt mutation frequency among workers exposed to 1,3-butadiene in China. Toxicology. 1996 Oct 28; 113(1-3):100-5. PMID: 8901888.
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    192. Wiencke JK, Wiemels J. Genotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Mutat Res. 1995 Jun; 339(2):91-119. PMID: 7791804.
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    193. Rothman N, Haas R, Hayes RB, Li GL, Wiemels J, Campleman S, Quintana PJ, Xi LJ, Dosemeci M, Titenko-Holland N. Benzene induces gene-duplicating but not gene-inactivating mutations at the glycophorin A locus in exposed humans. Proc Natl Acad Sci U S A. 1995 Apr 25; 92(9):4069-73. PMID: 7732033; PMCID: PMC42104.
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    194. Smith MT, Wiemels J, Rothman N, Linet MS. Chemical exposure, ras oncogene activation, and acute myeloid leukemia. J Natl Cancer Inst. 1992 Nov 04; 84(21):1614-5. PMID: 1433339.
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    195. Levison BS, Wiemels J, Szasz J, Sternlicht H. Ethoxyformylation of tubulin with [3H]diethyl pyrocarbonate: a reexamination of the mechanism of assembly inhibition. Biochemistry. 1989 Oct 31; 28(22):8877-84. PMID: 2605229.
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