Neil Pravin Shah, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, MSB
San Francisco CA 94117
Phone415-514-0269
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    Collapse Biography 
    Collapse Education and Training
    University of California Los AngelesM.D.1996School of Medicine
    University of California, San Francisco, CA2019Diversity, Equity, and Inclusion Champion Training

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Pre-IND study of PMT-254, a pan-FLT3 inhibitor for the treatment of FLT3 driven cancers.
    NIH R41CA199753Sep 23, 2015 - Aug 31, 2016
    Role: Principal Investigator
    Discovery and Development of a Selective pan-FLT3-ITD Kinase Inhibitor Clinical Candidate for the Treatment of FLT3-ITD-Driven AML
    NIH R01CA194094Aug 1, 2015 - Jul 31, 2019
    Role: Principal Investigator
    Crenolanib and ponatinib for the treatment of FLT3 mutant AML
    NIH R01CA176091Apr 8, 2013 - Mar 31, 2018
    Role: Principal Investigator
    Mechanisms of resistance to clinically-effective FLT3 kinase inhibitors in AML
    NIH R01CA166616Apr 17, 2012 - Mar 31, 2017
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Germline Variants Identified in Patients with Early-onset Renal Cell Carcinoma Referred for Germline Genetic Testing. Eur Urol Oncol. 2021 Oct 12. Truong H, Sheikh R, Kotecha R, Kemel Y, Reisz PA, Lenis AT, Mehta NN, Khurram A, Joseph V, Mandelker D, Latham A, Ceyhan-Birsoy O, Ladanyi M, Shah NJ, Walsh MF, Voss MH, Lee CH, Russo P, Coleman JA, Hakimi AA, Feldman DR, Stadler ZK, Robson ME, Motzer RJ, Offit K, Patil S, Carlo MI. PMID: 34654685.
      View in: PubMed   Mentions:    Fields:    
    2. PET/CT scan and biopsy-driven approach for safe anti-PD-1 therapy discontinuation in patients with advanced melanoma. J Immunother Cancer. 2021 Oct; 9(10). Gibney GT, Zaemes J, Shand S, Shah NJ, Swoboda D, Gardner K, Radfar A, Petronic-Rosic V, Reilly MJ, Al-Refaie WB, Rapisuwon S, Atkins MB. PMID: 34599027; PMCID: PMC8488718.
      View in: PubMed   Mentions:    Fields:    
    3. Patient-Reported Functional Outcomes in Patients with Chronic Myeloid Leukemia after Stopping Tyrosine Kinase Inhibitors. J Natl Cancer Inst. 2021 Sep 07. Schoenbeck KL, Atallah E, Lin L, Weinfurt KP, Cortes J, Deininger MWN, Kota V, Larson RA, Mauro MJ, Oehler VG, Pinilla-Ibarz J, Radich JP, Schiffer CA, Shah NP, Silver RT, Thompson JE, Flynn KE. PMID: 34491344.
      View in: PubMed   Mentions:    Fields:    
    4. The EBF1-PDGFRB T681I mutation is highly resistant to imatinib and dasatinib in vitro and detectable in clinical samples prior to treatment. Haematologica. 2021 08 01; 106(8):2242-2245. Tran TH, Nguyen JV, Stecula A, Akutagawa J, Moorman AV, Braun BS, Sali A, Mullighan CG, Shah NP, Dai Y, Devidas M, Roberts KG, Smith CC, Loh ML. PMID: 33626861.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Immune tolerance with combined allogeneic haplo-identical haematopoietic stem cell transplant and renal transplant. Br J Haematol. 2021 Aug; 194(4):779-783. Doucette K, Shah NJ, Donato ML, Siegel DS, Rowley SD, Vesole DH. PMID: 34137024.
      View in: PubMed   Mentions:    Fields:    
    6. Recurrent Mutations in Cyclin D3 Confer Clinical Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia. Clin Cancer Res. 2021 Jul 15; 27(14):4003-4011. Smith CC, Viny AD, Massi E, Kandoth C, Socci ND, Rapaport F, Najm M, Medina-Martinez JS, Papaemmanuil E, Tarver TC, Hsu HH, Le MH, West B, Bollag G, Taylor BS, Levine RL, Shah NP. PMID: 34103301.
      View in: PubMed   Mentions:    Fields:    
    7. Success and failure of additional immune modulators in steroid-refractory/resistant pneumonitis related to immune checkpoint blockade. J Immunother Cancer. 2021 02; 9(2). Beattie J, Rizvi H, Fuentes P, Luo J, Schoenfeld A, Lin IH, Postow M, Callahan M, Voss MH, Shah NJ, Betof Warner A, Chawla M, Hellmann MD. PMID: 33568350.
      View in: PubMed   Mentions: 1     Fields:    
    8. Salvage Ipilimumab and Nivolumab in Patients With Metastatic Renal Cell Carcinoma After Prior Immune Checkpoint Inhibitors. J Clin Oncol. 2020 09 20; 38(27):3088-3094. Gul A, Stewart TF, Mantia CM, Shah NJ, Gatof ES, Long Y, Allman KD, Ornstein MC, Hammers HJ, McDermott DF, Atkins MB, Hurwitz M, Rini BI. PMID: 32491962.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    9. Safety and efficacy of immune checkpoint inhibitors (ICIs) in cancer patients with HIV, hepatitis B, or hepatitis C viral infection. J Immunother Cancer. 2019 12 17; 7(1):353. Shah NJ, Al-Shbool G, Blackburn M, Cook M, Belouali A, Liu SV, Madhavan S, He AR, Atkins MB, Gibney GT, Kim C. PMID: 31847881.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    10. Dasatinib discontinuation in patients with chronic-phase chronic myeloid leukemia and stable deep molecular response: the DASFREE study. Leuk Lymphoma. 2020 03; 61(3):650-659. Shah NP, García-Gutiérrez V, Jiménez-Velasco A, Larson S, Saussele S, Rea D, Mahon FX, Levy MY, Gómez-Casares MT, Pane F, Nicolini FE, Mauro MJ, Sy O, Martin-Regueira P, Lipton JH. PMID: 31647335.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCTClinical Trials
    11. Nationwide randomised trial evaluating elective neck dissection for early stage oral cancer (SEND study) with meta-analysis and concurrent real-world cohort. Br J Cancer. 2019 11; 121(10):827-836. Hutchison IL, Ridout F, Cheung SMY, Shah N, Hardee P, Surwald C, Thiruchelvam J, Cheng L, Mellor TK, Brennan PA, Baldwin AJ, Shaw RJ, Halfpenny W, Danford M, Whitley S, Smith G, Bailey MW, Woodwards B, Patel M, McManners J, Chan CH, Burns A, Praveen P, Camilleri AC, Avery C, Putnam G, Jones K, Webster K, Smith WP, Edge C, McVicar I, Grew N, Hislop S, Kalavrezos N, Martin IC, Hackshaw A. PMID: 31611612.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    12. ATP-Competitive Inhibitors Midostaurin and Avapritinib Have Distinct Resistance Profiles in Exon 17-Mutant KIT. Cancer Res. 2019 08 15; 79(16):4283-4292. Apsel Winger B, Cortopassi WA, Garrido Ruiz D, Ding L, Jang K, Leyte-Vidal A, Zhang N, Esteve-Puig R, Jacobson MP, Shah NP. PMID: 31270078.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    13. Product review on the Anti-PD-L1 antibody atezolizumab. Hum Vaccin Immunother. 2018 02 01; 14(2):269-276. Shah NJ, Kelly WJ, Liu SV, Choquette K, Spira A. PMID: 29194007.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    14. Front-Line Treatment Options for Chronic-Phase Chronic Myeloid Leukemia. J Clin Oncol. 2018 01 20; 36(3):220-224. Shah NP. PMID: 29206554.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    15. Evaluation of cardiovascular ischemic event rates in dasatinib-treated patients using standardized incidence ratios. Ann Hematol. 2017 Aug; 96(8):1303-1313. Saglio G, le Coutre P, Cortes J, Mayer J, Rowlings P, Mahon FX, Kroog G, Gooden K, Subar M, Shah NP. PMID: 28534184.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    16. NCCN Guidelines Insights: Chronic Myeloid Leukemia, Version 1.2017. J Natl Compr Canc Netw. 2016 12; 14(12):1505-1512. Pallera A, Altman JK, Berman E, Abboud CN, Bhatnagar B, Curtin P, DeAngelo DJ, Gotlib J, Hagelstrom RT, Hobbs G, Jagasia M, Kantarjian HM, Kropf P, Metheny L, Moore JO, Ontiveros E, Purev E, Quiery A, Reddy VV, Rose MG, Shah NP, Smith BD, Snyder DS, Sweet KL, Tibes R, Yang DT, Gregory K, Sundar H, Deininger M, Radich JP. PMID: 27956535.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    17. Stem cell transplantation for tetratricopeptide repeat domain 7A deficiency: long-term follow-up. Blood. 2016 09 01; 128(9):1306-8. Kammermeier J, Lucchini G, Pai SY, Worth A, Rampling D, Amrolia P, Silva J, Chiesa R, Rao K, Noble-Jamieson G, Gasparetto M, Ellershaw D, Uhlig H, Sebire N, Elawad M, Notarangelo L, Shah N, Veys P. PMID: 27418642.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    18. Dasatinib in imatinib-resistant or -intolerant chronic-phase, chronic myeloid leukemia patients: 7-year follow-up of study CA180-034. Am J Hematol. 2016 09; 91(9):869-74. Shah NP, Rousselot P, Schiffer C, Rea D, Cortes JE, Milone J, Mohamed H, Healey D, Kantarjian H, Hochhaus A, Saglio G. PMID: 27192969.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCTClinical Trials
    19. Final 5-Year Study Results of DASISION: The Dasatinib Versus Imatinib Study in Treatment-Naïve Chronic Myeloid Leukemia Patients Trial. J Clin Oncol. 2016 07 10; 34(20):2333-40. Cortes JE, Saglio G, Kantarjian HM, Baccarani M, Mayer J, Boqué C, Shah NP, Chuah C, Casanova L, Bradley-Garelik B, Manos G, Hochhaus A. PMID: 27217448.
      View in: PubMed   Mentions: 184     Fields:    Translation:HumansCTClinical Trials
    20. Cow's Milk Allergy Prescribing Is Influenced by Regional and National Guidance. J Pediatr Gastroenterol Nutr. 2016 05; 62(5):765-70. Wauters L, Brown T, Venter C, Dziubak R, Meyer R, Brogan B, Walsh J, Fox AT, Shah N. PMID: 26628440.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    21. Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease. Gut. 2017 06; 66(6):1060-1073. Schwerd T, Pandey S, Yang HT, Bagola K, Jameson E, Jung J, Lachmann RH, Shah N, Patel SY, Booth C, Runz H, Düker G, Bettels R, Rohrbach M, Kugathasan S, Chapel H, Keshav S, Elkadri A, Platt N, Muise AM, Koletzko S, Xavier RJ, Marquardt T, Powrie F, Wraith JE, Gyrd-Hansen M, Platt FM, Uhlig HH. PMID: 26953272.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    22. PPARγ: Welcoming the New Kid on the CML Stem Cell Block. Cancer Cell. 2015 Oct 12; 28(4):409-411. Apsel Winger B, Shah NP. PMID: 26461088.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    23. Clinical features of pulmonary arterial hypertension in patients receiving dasatinib. Am J Hematol. 2015 Nov; 90(11):1060-4. Shah NP, Wallis N, Farber HW, Mauro MJ, Wolf RA, Mattei D, Guha M, Rea D, Peacock A. PMID: 26284693.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    24. Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance. Sci Rep. 2015 Sep 30; 5:14538. Kesarwani M, Huber E, Kincaid Z, Evelyn CR, Biesiada J, Rance M, Thapa MB, Shah NP, Meller J, Zheng Y, Azam M. PMID: 26419724.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    25. Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397. Cancer Discov. 2015 Jun; 5(6):668-79. Smith CC, Zhang C, Lin KC, Lasater EA, Zhang Y, Massi E, Damon LE, Pendleton M, Bashir A, Sebra R, Perl A, Kasarskis A, Shellooe R, Tsang G, Carias H, Powell B, Burton EA, Matusow B, Zhang J, Spevak W, Ibrahim PN, Le MH, Hsu HH, Habets G, West BL, Bollag G, Shah NP. PMID: 25847190.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    26. Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy. Elife. 2014 Dec 22; 3. Warkentin AA, Lopez MS, Lasater EA, Lin K, He BL, Leung AY, Smith CC, Shah NP, Shokat KM. PMID: 25531068.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    27. Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis. Cell Rep. 2014 Nov 20; 9(4):1333-48. Chatterjee A, Ghosh J, Ramdas B, Mali RS, Martin H, Kobayashi M, Vemula S, Canela VH, Waskow ER, Visconte V, Tiu RV, Smith CC, Shah N, Bunting KD, Boswell HS, Liu Y, Chan RJ, Kapur R. PMID: 25456130.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    28. Sensitive and selective plasmon ruler nanosensors for monitoring the apoptotic drug response in leukemia. ACS Nano. 2014 Sep 23; 8(9):9199-208. Tajon CA, Seo D, Asmussen J, Shah N, Jun YW, Craik CS. PMID: 25166742.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    29. Verrucous carcinoma of the esophagus: A case report and literature review. World J Clin Cases. 2014 Jul 16; 2(7):284-8. Ramani C, Shah N, Nathan RS. PMID: 25032204.
      View in: PubMed   Mentions:
    30. Crenolanib is a selective type I pan-FLT3 inhibitor. Proc Natl Acad Sci U S A. 2014 Apr 08; 111(14):5319-24. Smith CC, Lasater EA, Lin KC, Wang Q, McCreery MQ, Stewart WK, Damon LE, Perl AE, Jeschke GR, Sugita M, Carroll M, Kogan SC, Kuriyan J, Shah NP. PMID: 24623852.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    31. Long-term outcome with dasatinib after imatinib failure in chronic-phase chronic myeloid leukemia: follow-up of a phase 3 study. Blood. 2014 Apr 10; 123(15):2317-24. Shah NP, Guilhot F, Cortes JE, Schiffer CA, le Coutre P, Brümmendorf TH, Kantarjian HM, Hochhaus A, Rousselot P, Mohamed H, Healey D, Cunningham M, Saglio G. PMID: 24569263.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCTClinical Trials
    32. Mutations in tetratricopeptide repeat domain 7A result in a severe form of very early onset inflammatory bowel disease. Gastroenterology. 2014 Apr; 146(4):1028-39. Avitzur Y, Guo C, Mastropaolo LA, Bahrami E, Chen H, Zhao Z, Elkadri A, Dhillon S, Murchie R, Fattouh R, Huynh H, Walker JL, Wales PW, Cutz E, Kakuta Y, Dudley J, Kammermeier J, Powrie F, Shah N, Walz C, Nathrath M, Kotlarz D, Puchaka J, Krieger JR, Racek T, Kirchner T, Walters TD, Brumell JH, Griffiths AM, Rezaei N, Rashtian P, Najafi M, Monajemzadeh M, Pelsue S, McGovern DP, Uhlig HH, Schadt E, Klein C, Snapper SB, Muise AM. PMID: 24417819.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    33. MEK-dependent negative feedback underlies BCR-ABL-mediated oncogene addiction. Cancer Discov. 2014 Feb; 4(2):200-15. Asmussen J, Lasater EA, Tajon C, Oses-Prieto J, Jun YW, Taylor BS, Burlingame A, Craik CS, Shah NP. PMID: 24362263.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    34. Phase I evaluation of XL019, an oral, potent, and selective JAK2 inhibitor. Leuk Res. 2014 Mar; 38(3):316-22. Verstovsek S, Tam CS, Wadleigh M, Sokol L, Smith CC, Bui LA, Song C, Clary DO, Olszynski P, Cortes J, Kantarjian H, Shah NP. PMID: 24374145.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCTClinical Trials
    35. What does a deep molecular response signify? J Clin Oncol. 2014 Feb 10; 32(5):471-4. Politi J, Shah NP. PMID: 24297955.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    36. Phenotypic characterization of very early-onset IBD due to mutations in the IL10, IL10 receptor alpha or beta gene: a survey of the Genius Working Group. Inflamm Bowel Dis. 2013 Dec; 19(13):2820-8. Pigneur B, Escher J, Elawad M, Lima R, Buderus S, Kierkus J, Guariso G, Canioni D, Lambot K, Talbotec C, Shah N, Begue B, Rieux-Laucat F, Goulet O, Cerf-Bensussan N, Neven B, Ruemmele FM. PMID: 24216686.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    37. Chronic Myelogenous Leukemia, Version 1.2014. J Natl Compr Canc Netw. 2013 Nov; 11(11):1327-40. O'Brien S, Radich JP, Abboud CN, Akhtari M, Altman JK, Berman E, DeAngelo DJ, Deininger M, Devine S, Fathi AT, Gotlib J, Jagasia M, Kropf P, Moore JO, Pallera A, Pinilla-Ibarz J, Reddy VV, Shah NP, Smith BD, Snyder DS, Wetzler M, Gregory K, Sundar H, Ntational comprehensive cancer network . PMID: 24225967.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    38. Role of ADAMTS13 in the management of thrombotic microangiopathies including thrombotic thrombocytopenic purpura (TTP). Br J Haematol. 2013 Nov; 163(4):514-9. Shah N, Rutherford C, Matevosyan K, Shen YM, Sarode R. PMID: 24111495.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    39. Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD. Blood. 2013 Apr 18; 121(16):3165-71. Smith CC, Lasater EA, Zhu X, Lin KC, Stewart WK, Damon LE, Salerno S, Shah NP. PMID: 23430109.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    40. The role of kinase inhibitors in the treatment of patients with acute myeloid leukemia. Am Soc Clin Oncol Educ Book. 2013; 313-8. Smith CC, Shah NP. PMID: 23714533.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    41. Front-line TKI therapy for chronic-phase CML: the luxury of choice. Oncology (Williston Park). 2012 Oct; 26(10):908, 910, 912. Shah NP. PMID: 23175996.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    42. Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. Nature. 2012 Apr 15; 485(7397):260-3. Smith CC, Wang Q, Chin CS, Salerno S, Damon LE, Levis MJ, Perl AE, Travers KJ, Wang S, Hunt JP, Zarrinkar PP, Schadt EE, Kasarskis A, Kuriyan J, Shah NP. PMID: 22504184.
      View in: PubMed   Mentions: 277     Fields:    Translation:HumansCells
    43. Advancing the STATus of MPN pathogenesis. Blood. 2012 Apr 12; 119(15):3374-6. Shah NP, Shannon K. PMID: 22500049.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    44. Mechanisms of resistance to targeted therapies in acute myeloid leukemia and chronic myeloid leukemia. Am Soc Clin Oncol Educ Book. 2012; 685-9. Smith CC, Shah NP. PMID: 24451819.
      View in: PubMed   Mentions:    Fields:    
    45. Ponatinib: targeting the T315I mutation in chronic myelogenous leukemia. Clin Adv Hematol Oncol. 2011 Dec; 9(12):925-6. Shah NP. PMID: 22252660.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    46. Is it downhill from here? Eliminating leukemic stem cells and curing chronic myeloid leukemia. Clin Cancer Res. 2011 Nov 01; 17(21):6605-7. Smith CC, Shah NP. PMID: 21948230.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    47. BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia. J Exp Med. 2011 Oct 24; 208(11):2163-74. Hurtz C, Hatzi K, Cerchietti L, Braig M, Park E, Kim YM, Herzog S, Ramezani-Rad P, Jumaa H, Müller MC, Hofmann WK, Hochhaus A, Ye BH, Agarwal A, Druker BJ, Shah NP, Melnick AM, Müschen M. PMID: 21911423.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    48. Tyrosine kinase inhibitor therapy for chronic myeloid leukemia: approach to patients with treatment-naive or refractory chronic-phase disease. Hematology Am Soc Hematol Educ Program. 2011; 2011:121-7. Smith CC, Shah NP. PMID: 22160023.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    49. Dasatinib 140 mg once daily versus 70 mg twice daily in patients with Ph-positive acute lymphoblastic leukemia who failed imatinib: Results from a phase 3 study. Am J Hematol. 2010 Mar; 85(3):164-70. Lilly MB, Ottmann OG, Shah NP, Larson RA, Reiffers JJ, Ehninger G, Müller MC, Charbonnier A, Bullorsky E, Dombret H, Brigid Bradley-Garelik M, Zhu C, Martinelli G. PMID: 20131302.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCTClinical Trials
    50. Potent, transient inhibition of BCR-ABL with dasatinib 100 mg daily achieves rapid and durable cytogenetic responses and high transformation-free survival rates in chronic phase chronic myeloid leukemia patients with resistance, suboptimal response or intolerance to imatinib. Haematologica. 2010 Feb; 95(2):232-40. Shah NP, Kim DW, Kantarjian H, Rousselot P, Llacer PE, Enrico A, Vela-Ojeda J, Silver RT, Khoury HJ, Müller MC, Lambert A, Matloub Y, Hochhaus A. PMID: 20139391.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCTClinical Trials
    51. Fine-tuning targeted therapy of CML. Blood. 2009 Dec 03; 114(24):4914-5. Shah NP. PMID: 19965702.
      View in: PubMed   Mentions:    Fields:    
    52. Clonal hematopoiesis in Philadelphia chromosome-negative bone marrow cells of chronic myeloid leukemia patients receiving dasatinib. Leuk Res. 2010 Jun; 34(6):708-13. Paquette RL, Nicoll J, Chalukya M, Gondek L, Jasek M, Sawyers CL, Shah NP, Maciejewski J. PMID: 19804904.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    53. Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia resistant to imatinib at a dose of 400 to 600 milligrams daily: two-year follow-up of a randomized phase 2 study (START-R). Cancer. 2009 Sep 15; 115(18):4136-47. Kantarjian H, Pasquini R, Lévy V, Jootar S, Holowiecki J, Hamerschlak N, Hughes T, Bleickardt E, Dejardin D, Cortes J, Shah NP. PMID: 19536906.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCTClinical Trials
    54. Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations. Cancer Res. 2009 Mar 15; 69(6):2384-92. Seeliger MA, Ranjitkar P, Kasap C, Shan Y, Shaw DE, Shah NP, Kuriyan J, Maly DJ. PMID: 19276351.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    55. Transient potent BCR-ABL inhibition is sufficient to commit chronic myeloid leukemia cells irreversibly to apoptosis. Cancer Cell. 2008 Dec 09; 14(6):485-93. Shah NP, Kasap C, Weier C, Balbas M, Nicoll JM, Bleickardt E, Nicaise C, Sawyers CL. PMID: 19061839.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansCells
    56. Intermittent target inhibition with dasatinib 100 mg once daily preserves efficacy and improves tolerability in imatinib-resistant and -intolerant chronic-phase chronic myeloid leukemia. J Clin Oncol. 2008 Jul 01; 26(19):3204-12. Shah NP, Kantarjian HM, Kim DW, Réa D, Dorlhiac-Llacer PE, Milone JH, Vela-Ojeda J, Silver RT, Khoury HJ, Charbonnier A, Khoroshko N, Paquette RL, Deininger M, Collins RH, Otero I, Hughes T, Bleickardt E, Strauss L, Francis S, Hochhaus A. PMID: 18541900.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansCTClinical Trials
    57. Dasatinib induces durable cytogenetic responses in patients with chronic myelogenous leukemia in chronic phase with resistance or intolerance to imatinib. Leukemia. 2008 Jun; 22(6):1200-6. Hochhaus A, Baccarani M, Deininger M, Apperley JF, Lipton JH, Goldberg SL, Corm S, Shah NP, Cervantes F, Silver RT, Niederwieser D, Stone RM, Dombret H, Larson RA, Roy L, Hughes T, Müller MC, Ezzeddine R, Countouriotis AM, Kantarjian HM. PMID: 18401416.
      View in: PubMed   Mentions: 118     Fields:    Translation:Humans
    58. Advanced CML: therapeutic options for patients in accelerated and blast phases. J Natl Compr Canc Netw. 2008 Mar; 6 Suppl 2:S31-S36. Shah NP. PMID: 18397679.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    59. Progressive thoughts about progressive disease. Clin Cancer Res. 2007 Sep 15; 13(18 Pt 1):5229-31. Shah NP. PMID: 17875748.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    60. Sequential ABL kinase inhibitor therapy selects for compound drug-resistant BCR-ABL mutations with altered oncogenic potency. J Clin Invest. 2007 Sep; 117(9):2562-9. Shah NP, Skaggs BJ, Branford S, Hughes TP, Nicoll JM, Paquette RL, Sawyers CL. PMID: 17710227.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    61. Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: a randomized phase 2 trial. Blood. 2007 Jun 15; 109(12):5143-50. Kantarjian H, Pasquini R, Hamerschlak N, Rousselot P, Holowiecki J, Jootar S, Robak T, Khoroshko N, Masszi T, Skotnicki A, Hellmann A, Zaritsky A, Golenkov A, Radich J, Hughes T, Countouriotis A, Shah N. PMID: 17317857.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCTClinical Trials
    62. ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia. Blood. 2007 Apr 15; 109(8):3400-8. Shankar DB, Li J, Tapang P, Owen McCall J, Pease LJ, Dai Y, Wei RQ, Albert DH, Bouska JJ, Osterling DJ, Guo J, Marcotte PA, Johnson EF, Soni N, Hartandi K, Michaelides MR, Davidsen SK, Priceman SJ, Chang JC, Rhodes K, Shah N, Moore TB, Sakamoto KM, Glaser KB. PMID: 17209055.
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    63. Dasatinib. Drugs Today (Barc). 2007 Jan; 43(1):5-12. Shah NP. PMID: 17315048.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    64. Medical management of CML. Hematology Am Soc Hematol Educ Program. 2007; 371-5. Shah NP. PMID: 18024653.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    65. Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis. Blood. 2007 Apr 15; 109(8):3207-13. Cortes J, Rousselot P, Kim DW, Ritchie E, Hamerschlak N, Coutre S, Hochhaus A, Guilhot F, Saglio G, Apperley J, Ottmann O, Shah N, Erben P, Branford S, Agarwal P, Gollerkeri A, Baccarani M. PMID: 17185463.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansCTClinical Trials
    66. Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy. Blood. 2007 Mar 15; 109(6):2303-9. Hochhaus A, Kantarjian HM, Baccarani M, Lipton JH, Apperley JF, Druker BJ, Facon T, Goldberg SL, Cervantes F, Niederwieser D, Silver RT, Stone RM, Hughes TP, Muller MC, Ezzeddine R, Countouriotis AM, Shah NP. PMID: 17138817.
      View in: PubMed   Mentions: 166     Fields:    Translation:HumansCTClinical Trials
    67. Gene expression changes associated with progression and response in chronic myeloid leukemia. Proc Natl Acad Sci U S A. 2006 Feb 21; 103(8):2794-9. Radich JP, Dai H, Mao M, Oehler V, Schelter J, Druker B, Sawyers C, Shah N, Stock W, Willman CL, Friend S, Linsley PS. PMID: 16477019.
      View in: PubMed   Mentions: 196     Fields:    Translation:Humans
    68. Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680. Cancer Res. 2006 Jan 15; 66(2):1007-14. Young MA, Shah NP, Chao LH, Seeliger M, Milanov ZV, Biggs WH, Treiber DK, Patel HK, Zarrinkar PP, Lockhart DJ, Sawyers CL, Kuriyan J. PMID: 16424036.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    69. Dynamics of chronic myeloid leukaemia. Nature. 2005 Jun 30; 435(7046):1267-70. Michor F, Hughes TP, Iwasa Y, Branford S, Shah NP, Sawyers CL, Nowak MA. PMID: 15988530.
      View in: PubMed   Mentions: 259     Fields:    Translation:HumansCells
    70. Loss of response to imatinib: mechanisms and management. Hematology Am Soc Hematol Educ Program. 2005; 183-7. Shah NP. PMID: 16304378.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    71. Detection of BCR-ABL kinase mutations in CD34+ cells from chronic myelogenous leukemia patients in complete cytogenetic remission on imatinib mesylate treatment. Blood. 2005 Mar 01; 105(5):2093-8. Chu S, Xu H, Shah NP, Snyder DS, Forman SJ, Sawyers CL, Bhatia R. PMID: 15345592.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    72. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science. 2004 Jul 16; 305(5682):399-401. Shah NP, Tran C, Lee FY, Chen P, Norris D, Sawyers CL. PMID: 15256671.
      View in: PubMed   Mentions: 463     Fields:    Translation:HumansAnimalsCells
    73. Mechanisms of resistance to STI571 in Philadelphia chromosome-associated leukemias. Oncogene. 2003 Oct 20; 22(47):7389-95. Shah NP, Sawyers CL. PMID: 14576846.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    74. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell. 2002 Aug; 2(2):117-25. Shah NP, Nicoll JM, Nagar B, Gorre ME, Paquette RL, Kuriyan J, Sawyers CL. PMID: 12204532.
      View in: PubMed   Mentions: 487     Fields:    Translation:HumansCells
    75. Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10700-5. Roumiantsev S, Shah NP, Gorre ME, Nicoll J, Brasher BB, Sawyers CL, Van Etten RA. PMID: 12149456.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
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