Matthew Stachler, MD, PhD
Overview
Clinically, I am a Molecular Pathologist focused on using advanced, cutting edge tests to drive personalized medicine in cancer diagnostics and treatment.
My lab works to understand the process of premalignant progression to invasive cancer, specifically focusing on cancers (esophageal and gastric adenocarcinoma) and pre-malignant conditions (columnar and intestinal metaplasia or Barrett’s esophagus) of the upper gastrointestinal tract as a model system.
As a disease that is often closely monitored and sampled, Barrett’s esophagus and esophageal adenocarcinoma provides an idea system to study the changes leading up to and driving invasive disease. Additionally, Barrett’s esophagus and esophageal adenocarcinoma are extremely important diseases to understand in their own as esophageal adenocarcinoma has one of the fastest rising incidences of any solid tumor and despite our understanding that it arises from a metaplastic field, we still do an extremely poor job of identifying patients early before advanced disease develops.
We have taken the approach to first understand the factors important in human tissues through advanced ‘omics’ and digital imaging approaches and then use this understanding to build model systems and functional studies. It is our goal to use the knowledge and understanding gained in these studies to develop novel biomarkers, screening strategies, and treatments to identify and treat people early before advanced disease develops.
Research
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
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Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
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HER2 overexpression in urothelial carcinoma with GATA3 and PPARG copy number gains. Oncologist. 2024 Aug 05; 29(8):e1094-e1097.
Zhu X, Chan E, Turski ML, Mendez CE, Hsu SC, Kumar V, Shipp C, Jindal T, Chang K, Onodera C, Devine WP, Grenert JP, Stohr BA, Ding CC, Stachler MD, Quigley DA, Feng FY, Chu CE, Porten SP, Chou J, Friedlander TW, Koshkin VS. PMID: 38908022; PMCID: PMC11299940.
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Humans
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Molecular Analysis of Persistent and Recurrent Barrett's Esophagus in the Setting of Endoscopic Therapy. Clin Transl Gastroenterol. 2024 Aug 01; 15(8):e00751.
Kumar A, Rara M, Yu M, Wen KW, Grady WM, Chak A, Iyer PG, Rustgi AK, Wang TC, Rubenstein JH, Liu Y, Kresty L, Westerhoff M, Kwon RS, Wamsteker E, Wang T, Berry L, Canto MI, Shaheen NJ, Wang KK, Abrams JA, Stachler MD. PMID: 39007490; PMCID: PMC11346883.
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Humans
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Expansion of a bacterial operon during cancer treatment ameliorates drug toxicity. bioRxiv. 2024 Jun 06.
Trepka KR, Kidder WA, Kyaw TS, Olson CA, Upadhyay V, Noecker C, Stanfield D, Steiding P, Spanogiannopoulos P, Dumlao D, Turnbaugh JA, Stachler MD, Van Blarigan EL, Venook AP, Atreya CE, Turnbaugh PJ. PMID: 38895199; PMCID: PMC11185696.
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Molecular Pathology of Gastroesophageal Cancer. Clin Lab Med. 2024 Jun; 44(2):239-254.
Stachler MD, Jin RU. PMID: 38821643.
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Humans
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Refining definitions of Barrett's oesophagus to improve clinical resource utilisation. Gut. 2024 04 05; 73(5):715-716.
Stachler MD, Ain QU. PMID: 38216329.
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Humans
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Feasibility Study Utilizing NanoString's Digital Spatial Profiling (DSP) Technology for Characterizing the Immune Microenvironment in Barrett's Esophagus Formalin-Fixed Paraffin-Embedded Tissues. Cancers (Basel). 2023 Dec 18; 15(24).
Frei NF, Khoshiwal AM, Stougie P, Odze R, Camilleri-Broet S, Ferri L, Duits LC, Bergman J, Stachler MD. PMID: 38136440; PMCID: PMC10742302.
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Genomic signatures of past and present chromosomal instability in Barrett's esophagus and early esophageal adenocarcinoma. Nat Commun. 2023 10 04; 14(1):6203.
Bao C, Tourdot RW, Brunette GJ, Stewart C, Sun L, Baba H, Watanabe M, Agoston AT, Jajoo K, Davison JM, Nason KS, Getz G, Wang KK, Imamura Y, Odze R, Bass AJ, Stachler MD, Zhang CZ. PMID: 37794034; PMCID: PMC10550953.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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TSP-9: A Barrett's Esophagus Biomarker Better Than Pathologists? Gastroenterology. 2023 11; 165(5):1106-1107.
Rubenstein JH, Stachler MD. PMID: 37659675.
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Humans
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Interleukin-33 as a Potential Therapeutic Target in Gastric Cancer Patients: Current Insights. Onco Targets Ther. 2023; 16:675-687.
Chatterjee A, Azevedo-Martins JM, Stachler MD. PMID: 37583706; PMCID: PMC10424681.
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1
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Concerted epithelial and stromal changes during progression of Barrett's Esophagus to invasive adenocarcinoma exposed by multi-scale, multi-omics analysis. bioRxiv. 2023 Jun 11.
Strasser MK, Gibbs DL, Gascard P, Bons J, Hickey JW, Schürch CM, Tan Y, Black S, Chu P, Ozkan A, Basisty N, Sangwan V, Rose J, Shah S, Camilleri-Broet S, Fiset PO, Bertos N, Berube J, Djambazian H, Li R, Oikonomopoulos S, Fels-Elliott DR, Vernovsky S, Shimshoni E, Collyar D, Russell A, Ragoussis I, Stachler M, Goldenring JR, McDonald S, Ingber DE, Schilling B, Nolan GP, Tlsty TD, Huang S, Ferri LE. PMID: 37333362; PMCID: PMC10274886.
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Bridging the Gap between Diseases of the Stomach and Lower Esophagus. Cancer Discov. 2023 06 02; 13(6):1291-1293.
Stachler MD. PMID: 37264822.
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1 Fields:
Translation:
Humans
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Degree of crypt atypia correlates with progression to high-grade dysplasia/adenocarcinoma in non-dysplastic Barrett's oesophagus. Histopathology. 2023 Sep; 83(3):406-413.
Odze R, Frei N, Khoshiwal AM, Duits LC, Bergman J, Stachler MD. PMID: 37199687; PMCID: PMC10562012.
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Humans
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Epithelial-Stromal Interactions in Barrett's Esophagus Modeled in Human Organ Chips. Gastro Hep Adv. 2023; 2(5):676-680.
Shimshoni E, Merry GE, Milot ZD, Oh CY, Horvath V, Gould RA, Caruso JA, Chen-Tanyolac C, Gascard P, Sangwan V, Bérubé J, Bailey SD, Hall S, Stachler MD, Ferri L, Tlsty TD, Ingber DE. PMID: 39129866; PMCID: PMC11308040.
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1
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Pilot Study Showing Feasibility of Phosphoproteomic Profiling of Pathway-Level Molecular Alterations in Barrett's Esophagus. Genes (Basel). 2022 07 07; 13(7).
Moore J, Hekman R, Blum BC, Lawton M, Lehoux S, Stachler M, Pleskow D, Sawhney MS, Cummings RD, Emili A, Qureshi A. PMID: 35885999; PMCID: PMC9325186.
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Humans
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Today's Mistakes and Tomorrow's Wisdom in Development and Use of Biomarkers for Barrett's Esophagus. Visc Med. 2022 Jun; 38(3):173-181.
Frei NF, Stachler MD. PMID: 35814971; PMCID: PMC9210037.
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PubMed Mentions:
1
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Abnormal TP53 Predicts Risk of Progression in Patients With Barrett's Esophagus Regardless of a Diagnosis of Dysplasia. Gastroenterology. 2022 02; 162(2):468-481.
Redston M, Noffsinger A, Kim A, Akarca FG, Rara M, Stapleton D, Nowden L, Lash R, Bass AJ, Stachler MD. PMID: 34757142; PMCID: PMC9341495.
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24 Fields:
Translation:
Humans
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Twists and turns from "tumor in tumor" profiling: surveillance of chronic lymphocytic leukemia (CLL) leads to detection of a lung adenocarcinoma, whose genomic characterization alters the original hematologic diagnosis. Cold Spring Harb Mol Case Stud. 2021 08; 7(4).
Terraf P, Sholl LM, Davids MS, Awad MM, Garcia EP, MacConaill LE, Dal Cin P, Kim A, Lindeman NI, Stachler M, Hwang DH, Dubuc AM. PMID: 34074652; PMCID: PMC8327883.
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Humans
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Molecular Pathology of Gastroesophageal Cancer. Surg Pathol Clin. 2021 Sep; 14(3):443-453.
Stachler MD, Jin RU. PMID: 34373095.
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1 Fields:
Translation:
HumansCells
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Reprogramming of the esophageal squamous carcinoma epigenome by SOX2 promotes ADAR1 dependence. Nat Genet. 2021 06; 53(6):881-894.
Wu Z, Zhou J, Zhang X, Zhang Z, Xie Y, Liu JB, Ho ZV, Panda A, Qiu X, Cejas P, Cañadas I, Akarca FG, McFarland JM, Nagaraja AK, Goss LB, Kesten N, Si L, Lim K, Liu Y, Zhang Y, Baek JY, Liu Y, Patil DT, Katz JP, Hai J, Bao C, Stachler M, Qi J, Ishizuka JJ, Nakagawa H, Rustgi AK, Wong KK, Meyerson M, Barbie DA, Brown M, Long H, Bass AJ. PMID: 33972779; PMCID: PMC9124436.
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PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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Correction: Neoadjuvant and Adjuvant Pembrolizumab in Resectable Locally Advanced, Human Papillomavirus-unrelated Head and Neck Cancer: A Multicenter, Phase II Trial. Clin Cancer Res. 2021 Jan 01; 27(1):357.
Uppaluri R, Campbell KM, Egloff AM, Zolkind P, Skidmore ZL, Nussenbaum B, Paniello RC, Rich JT, Jackson R, Pipkorn P, Michel LS, Ley J, Oppelt P, Dunn GP, Barnell EK, Spies NC, Lin T, Li T, Mulder DT, Hanna Y, Cirlan I, Pugh TJ, Mudianto T, Riley R, Zhou L, Jo VY, Stachler MD, Hanna GJ, Kass J, Haddad R, Schoenfeld JD, Gjini E, Lako A, Thorstad W, Gay HA, Daly M, Rodig SJ, Hagemann IS, Kallogjeri D, Piccirillo JF, Chernock RD, Griffith M, Griffith OL, Adkins DR. PMID: 33397681.
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PubMed Mentions:
4 Fields:
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Can Genomic Sequencing Identify High-Risk Barrett's Esophagus Earlier Than Pathologists? Cancer Cell. 2020 11 09; 38(5):626-628.
Stachler MD, Bass AJ. PMID: 33171128.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Neoadjuvant and Adjuvant Pembrolizumab in Resectable Locally Advanced, Human Papillomavirus-Unrelated Head and Neck Cancer: A Multicenter, Phase II Trial. Clin Cancer Res. 2020 10 01; 26(19):5140-5152.
Uppaluri R, Campbell KM, Egloff AM, Zolkind P, Skidmore ZL, Nussenbaum B, Paniello RC, Rich JT, Jackson R, Pipkorn P, Michel LS, Ley J, Oppelt P, Dunn GP, Barnell EK, Spies NC, Lin T, Li T, Mulder DT, Hanna Y, Cirlan I, Pugh TJ, Mudianto T, Riley R, Zhou L, Jo VY, Stachler MD, Hanna GJ, Kass J, Haddad R, Schoenfeld JD, Gjini E, Lako A, Thorstad W, Gay HA, Daly M, Rodig SJ, Hagemann IS, Kallogjeri D, Piccirillo JF, Chernock RD, Griffith M, Griffith OL, Adkins DR. PMID: 32665297; PMCID: PMC7547532.
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PubMed Mentions:
109 Fields:
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HumansCellsCTClinical Trials
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Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model. Nat Genet. 2020 02; 52(2):219-230.
Sethi NS, Kikuchi O, Duronio GN, Stachler MD, McFarland JM, Ferrer-Luna R, Zhang Y, Bao C, Bronson R, Patil D, Sanchez-Vega F, Liu JB, Sicinska E, Lazaro JB, Ligon KL, Beroukhim R, Bass AJ. PMID: 32025000; PMCID: PMC7031028.
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31 Fields:
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HumansAnimalsCellsPHPublic Health
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Risk stratification in Barrett's esophagus patients with diagnoses of indefinite for dysplasia: the definite silver bullet has not (yet) been found. Gastrointest Endosc. 2020 01; 91(1):11-13.
Frei NF, Stachler MD, Bergman JJGHM. PMID: 31865984.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer. Cancer Discov. 2020 02; 10(2):288-305.
Zhang H, Schaefer A, Wang Y, Hodge RG, Blake DR, Diehl JN, Papageorge AG, Stachler MD, Liao J, Zhou J, Wu Z, Akarca FG, de Klerk LK, Derks S, Pierobon M, Hoadley KA, Wang TC, Church G, Wong KK, Petricoin EF, Cox AD, Lowy DR, Der CJ, Bass AJ. PMID: 31771969; PMCID: PMC7007383.
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61 Fields:
Translation:
HumansAnimalsCells
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Colorectal Adenocarcinoma, Not Just One Disease. Cell Mol Gastroenterol Hepatol. 2019; 8(2):293-294.
Stachler MD. PMID: 31129094; PMCID: PMC6717931.
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HumansCells
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Clinicopathologic and genetic characteristics of interval colorectal carcinomas favor origin from missed or incompletely excised precursors. Mod Pathol. 2019 05; 32(5):666-674.
Soong TR, Nayor J, Stachler MD, Perencevich M, Jajoo K, Saltzman JR, Lindeman NI, Srivastava A. PMID: 30455417.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Biomarkers for Barrett's esophagus - a contemporary review. Expert Rev Mol Diagn. 2018 11; 18(11):939-946.
Qureshi AP, Stachler MD, Haque O, Odze RD. PMID: 30345836.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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Subtypes of Barrett's oesophagus and oesophageal adenocarcinoma based on genome-wide methylation analysis. Gut. 2019 03; 68(3):389-399.
Yu M, Maden SK, Stachler M, Kaz AM, Ayers J, Guo Y, Carter KT, Willbanks A, Heinzerling TJ, O'Leary RM, Xu X, Bass A, Chandar AK, Chak A, Elliott R, Willis JE, Markowitz SD, Grady WM. PMID: 29884612; PMCID: PMC6565505.
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PubMed Mentions:
23 Fields:
Translation:
HumansCells
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Detection of Mutations in Barrett's Esophagus Before Progression to High-Grade Dysplasia or Adenocarcinoma. Gastroenterology. 2018 07; 155(1):156-167.
Stachler MD, Camarda ND, Deitrick C, Kim A, Agoston AT, Odze RD, Hornick JL, Nag A, Thorner AR, Ducar M, Noffsinger A, Lash RH, Redston M, Carter SL, Davison JM, Bass AJ. PMID: 29608884; PMCID: PMC6035092.
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PubMed Mentions:
65 Fields:
Translation:
Humans
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Mutational landscape of goblet cell carcinoids and adenocarcinoma ex goblet cell carcinoids of the appendix is distinct from typical carcinoids and colorectal adenocarcinomas. Mod Pathol. 2018 06; 31(6):989-996.
Johncilla M, Stachler M, Misdraji J, Lisovsky M, Yozu M, Lindeman N, Lauwers GY, Odze RD, Srivastava A. PMID: 29422640.
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13 Fields:
Translation:
Humans
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Genomic Heterogeneity as a Barrier to Precision Medicine in Gastroesophageal Adenocarcinoma. Cancer Discov. 2018 01; 8(1):37-48.
Pectasides E, Stachler MD, Derks S, Liu Y, Maron S, Islam M, Alpert L, Kwak H, Kindler H, Polite B, Sharma MR, Allen K, O'Day E, Lomnicki S, Maranto M, Kanteti R, Fitzpatrick C, Weber C, Setia N, Xiao SY, Hart J, Nagy RJ, Kim KM, Choi MG, Min BH, Nason KS, O'Keefe L, Watanabe M, Baba H, Lanman R, Agoston AT, Oh DJ, Dunford A, Thorner AR, Ducar MD, Wollison BM, Coleman HA, Ji Y, Posner MC, Roggin K, Turaga K, Chang P, Hogarth K, Siddiqui U, Gelrud A, Ha G, Freeman SS, Rhoades J, Reed S, Gydush G, Rotem D, Davison J, Imamura Y, Adalsteinsson V, Lee J, Bass AJ, Catenacci DV. PMID: 28978556; PMCID: PMC5894850.
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147 Fields:
Translation:
Humans
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CDK4/6 or MAPK blockade enhances efficacy of EGFR inhibition in oesophageal squamous cell carcinoma. Nat Commun. 2017 01 06; 8:13897.
Zhou J, Wu Z, Wong G, Pectasides E, Nagaraja A, Stachler M, Zhang H, Chen T, Zhang H, Liu JB, Xu X, Sicinska E, Sanchez-Vega F, Rustgi AK, Diehl JA, Wong KK, Bass AJ. PMID: 28059068; PMCID: PMC5227099.
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PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
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PIK3CA Mutations are Common in Many Tumor Types and are Often Associated With Other Driver Mutations. Appl Immunohistochem Mol Morphol. 2016 May-Jun; 24(5):313-9.
Stachler MD, Rinehart EM, Garcia E, Lindeman NI. PMID: 26067136.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Paired exome analysis of Barrett's esophagus and adenocarcinoma. Nat Genet. 2015 Sep; 47(9):1047-55.
Stachler MD, Taylor-Weiner A, Peng S, McKenna A, Agoston AT, Odze RD, Davison JM, Nason KS, Loda M, Leshchiner I, Stewart C, Stojanov P, Seepo S, Lawrence MS, Ferrer-Torres D, Lin J, Chang AC, Gabriel SB, Lander ES, Beer DG, Getz G, Carter SL, Bass AJ. PMID: 26192918; PMCID: PMC4552571.
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PubMed Mentions:
181 Fields:
Translation:
Humans
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Epithelial PD-L2 Expression Marks Barrett's Esophagus and Esophageal Adenocarcinoma. Cancer Immunol Res. 2015 Oct; 3(10):1123-1129.
Derks S, Nason KS, Liao X, Stachler MD, Liu KX, Liu JB, Sicinska E, Goldberg MS, Freeman GJ, Rodig SJ, Davison JM, Bass AJ. PMID: 26081225; PMCID: PMC4596773.
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PubMed Mentions:
74 Fields:
Translation:
HumansAnimalsCells
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Filter Paper-based Nucleic Acid Storage in High-throughput Solid Tumor Genotyping. Appl Immunohistochem Mol Morphol. 2015 May-Jun; 23(5):389-96.
Stachler M, Jia Y, Sharaf N, Wade J, Longtine J, Garcia E, Sholl LM. PMID: 25221956.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Genetic and Epigenetic Alterations in Barrett's Esophagus and Esophageal Adenocarcinoma. Gastroenterol Clin North Am. 2015 Jun; 44(2):473-89.
Kaz AM, Grady WM, Stachler MD, Bass AJ. PMID: 26021206; PMCID: PMC4449457.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
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Novel molecular insights from routine genotyping of colorectal carcinomas. Hum Pathol. 2015 Apr; 46(4):507-13.
Stachler MD, Rinehart E, Lindeman N, Odze R, Srivastava A. PMID: 25683705.
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PubMed Mentions:
17 Fields:
Translation:
Humans
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Src mutation induces acquired lapatinib resistance in ERBB2-amplified human gastroesophageal adenocarcinoma models. PLoS One. 2014; 9(10):e109440.
Hong YS, Kim J, Pectasides E, Fox C, Hong SW, Ma Q, Wong GS, Peng S, Stachler MD, Thorner AR, Van Hummelen P, Bass AJ. PMID: 25350844; PMCID: PMC4211679.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Induction of HIV-1-specific mucosal immune responses following intramuscular recombinant adenovirus serotype 26 HIV-1 vaccination of humans. J Infect Dis. 2015 Feb 15; 211(4):518-28.
Baden LR, Liu J, Li H, Johnson JA, Walsh SR, Kleinjan JA, Engelson BA, Peter L, Abbink P, Milner DA, Golden KL, Viani KL, Stachler MD, Chen BJ, Pau MG, Weijtens M, Carey BR, Miller CA, Swann EM, Wolff M, Loblein H, Seaman MS, Dolin R, Barouch DH. PMID: 25165165; PMCID: PMC4318919.
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PubMed Mentions:
44 Fields:
Translation:
HumansCellsCTClinical Trials
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Critical role for IL-1β in DNA damage-induced mucositis. Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6):E702-11.
Kanarek N, Grivennikov SI, Leshets M, Lasry A, Alkalay I, Horwitz E, Shaul YD, Stachler M, Voronov E, Apte RN, Pagano M, Pikarsky E, Karin M, Ghosh S, Ben-Neriah Y. PMID: 24469832; PMCID: PMC3926043.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Neonatal Fc receptor expression in dendritic cells mediates protective immunity against colorectal cancer. Immunity. 2013 Dec 12; 39(6):1095-107.
Baker K, Rath T, Flak MB, Arthur JC, Chen Z, Glickman JN, Zlobec I, Karamitopoulou E, Stachler MD, Odze RD, Lencer WI, Jobin C, Blumberg RS. PMID: 24290911; PMCID: PMC3902970.
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PubMed Mentions:
72 Fields:
Translation:
HumansAnimalsCells
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Case report: Calcifying fibrous tumor presenting as an asymptomatic pelvic mass. Indian J Radiol Imaging. 2011 Oct; 21(4):306-8.
Giardino AA, Ramaiya NH, Shinagare AB, Jagannathan JP, Stachler MD, Raut CP. PMID: 22223947; PMCID: PMC3249950.
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PubMed Mentions:
4
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Site-specific modification of AAV vector particles with biophysical probes and targeting ligands using biotin ligase. Mol Ther. 2008 Aug; 16(8):1467-73.
Stachler MD, Chen I, Ting AY, Bartlett JS. PMID: 18560418.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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Mosaic vectors comprised of modified AAV1 capsid proteins for efficient vector purification and targeting to vascular endothelial cells. Gene Ther. 2006 Jun; 13(11):926-31.
Stachler MD, Bartlett JS. PMID: 16482202.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Metabolic biotinylation provides a unique platform for the purification and targeting of multiple AAV vector serotypes. Mol Ther. 2006 Jul; 14(1):97-106.
Arnold GS, Sasser AK, Stachler MD, Bartlett JS. PMID: 16624620.
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PubMed Mentions:
31 Fields:
Translation:
HumansCells
This graph shows the total number of publications by year. To see the data as text,
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This graph shows the total number of publications by year. To return to the graph,
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Year | Publications |
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2006 | 2 |
2008 | 1 |
2011 | 1 |
2013 | 1 |
2014 | 3 |
2015 | 5 |
2016 | 1 |
2017 | 2 |
2018 | 5 |
2019 | 2 |
2020 | 4 |
2021 | 5 |
2022 | 2 |
2023 | 8 |
2024 | 5 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
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