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Thea Tlsty, PhD

Title(s)Professor, Pathology
SchoolSchool of Medicine
Address513 Parnassus Ave, HSW
San Francisco CA 94143
Phone415-502-6116
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    Dr. Tlsty has over 25 years of experience in studying human cells and the earliest responses to injury. She has lead multi-disciplinary groups that address both the epithelial and stromal contributions to wound healing and malignancy. The model systems the Tlsty laboratory has developed and the applied translational insights obtained have great potential to contribute to clinical utility.

    Our work was the first to develop biomarkers for risk stratification of ductal carcinoma in situ, a pre-malignant lesion of breast cancer. Our recent work has identified molecular aspects of stromal-epithelial stress responses and the interactions that facilitate tumor progression in breast, prostate and other cancers. These analyses have enabled us to identify cell-extrinsic consequences of epithelial stress that lead to the activation of pro-tumorigenic stromal phenotypes. One of the most profound phenotypes involves the activation of a multicellular stromal program shared by high mammographic density and desmoplastic tumor tissues, characterized by repression of CD36. While studying these interactions we unexpectedly found a rare population of cells within disease-free tissue that has the potential to attain pluripotency. These cells have the ability to create functional tissues of all three germ layers which we hypothesize may be involved in metaplasia and inflammatory diseases. A single pluripotent cell can generate beating cardiomyocytes, lactating breast, bone, cartilage, vasculature, adipocytes, pancreas, and intestinal cells. We hypothesize that these cells may be the cell-of-origin for metaplastic cancers and provide insights for the identification of novel therapeutic targets. Similarly, these cells may be responsible for a wide collection of phenotypes that are initiated by chronic stress and defective in a wide spectrum of cancers. Our current studies, couched in a large multi-disciplinary, multi-investigator grant, are aimed at investigating the role of chronic inflammation in increased cancer incidence with the intent of developing preventive and therapeutic solutions.

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    Collapse Research Activities and Funding
    Plastic States Associated with Cellular Stress and Malignancy: Insights for Prevention and Treatment of Lethal Metaplastic Cancers
    NIH/NCI R35CA197694Jan 19, 2016 - Dec 31, 2022
    Role: Principal Investigator
    CD36-dependent stromal signaling orchestrates acquisition of pro-tumorigenic phenotypes
    NIH/NCI R01CA197977Jul 1, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Using Stromal Markers to Improve Risk Stratification of Ductal Carcinoma in Situ
    NIH/NCI R01CA187800Apr 1, 2015 - Mar 31, 2020
    Role: Principal Investigator
    Explosive Evolution Under Stress: The Driving Forces of Cancer Dynamics (Main)
    NIH U54CA143803Sep 28, 2009 - Jul 31, 2014
    Role: Co-Investigator
    Characterizing the Evolution of Pre-malignant Tissues at High Risk for Malignancy
    NIH/NCI R01CA135626Sep 18, 2008 - Aug 31, 2011
    Role: Co-Principal Investigator
    Biological Basis of Breast Density and Cancer Risk
    NIH/NCI P01CA107584Aug 10, 2006 - Feb 28, 2013
    Role: Principal Investigator
    Regulation of DNA hypermethylation in human mammary cells
    NIH/NCI R01CA122024Jul 1, 2006 - Jun 30, 2010
    Role: Principal Investigator
    Regulation of Genomic Instability in Early Breast Cancer
    NIH/NCI R01CA097214Jul 1, 2002 - May 31, 2009
    Role: Principal Investigator
    10TH INTERNATIONAL P53 WORKSHOP
    NIH/NCI R13CA085309Mar 1, 2000 - Feb 28, 2001
    Role: Principal Investigator
    FIBROBLAST REGULATION OF HUMAN PROSTATIC CARCINOGENESIS
    NIH/NCI R01CA083812Feb 1, 2000 - Jan 31, 2004
    Role: Principal Investigator
    Cancer Center Support Grant
    NIH/NCI P30CA082103Aug 5, 1999 - Sep 29, 2012
    Role: Co-Investigator
    MECHANISMS OF RADIATION--INDUCED GENOMIC INSTABILITY
    NIH/NCI R01CA073952Sep 30, 1997 - Sep 29, 2002
    Role: Principal Investigator
    CONTROL OF GENOMIC FLUIDITY IN CANCER CELLS
    NIH/NCI R01CA058413Mar 1, 1993 - Jun 30, 1995
    Role: Principal Investigator
    GENE AMPLIFICATION TO STUDY NEOPLASIA
    NIH/NCI R01CA051912Aug 8, 1991 - Nov 30, 1998
    Role: Principal Investigator
    CYCLE-DEPENDENT MECHANISMS OF CHEMICAL CARCINOGENESIS
    NIH P01CA042765Apr 1, 1988 - Apr 30, 2001
    Role: Co-Investigator
    CELLULAR ADAPTATION AND ENVIRONMENTAL CARCINOGENESIS
    NIH/NCI R01CA043110Jul 1, 1987 - Dec 31, 1990
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A framework for advancing our understanding of cancer-associated fibroblasts. Nat Rev Cancer. 2020 03; 20(3):174-186. Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, Hynes RO, Jain RK, Janowitz T, Jorgensen C, Kimmelman AC, Kolonin MG, Maki RG, Powers RS, Puré E, Ramirez DC, Scherz-Shouval R, Sherman MH, Stewart S, Tlsty TD, Tuveson DA, Watt FM, Weaver V, Weeraratna AT, Werb Z. PMID: 31980749.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    2. Stromal directives can control cancer. Science. 2019 07 12; 365(6449):122-123. Tlsty TD, Gascard P. PMID: 31296756.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Introducing cancer convergence. Cancer Converg. 2017; 1(1):3. Blagoev KB, Ting DT, Levine H, Saenger Y, Tlsty TD, Sun B. PMID: 29623955.
      View in: PubMed   Mentions:
    4. Metastatic State of Cancer Cells May Be Indicated by Adhesion Strength. Biophys J. 2017 Feb 28; 112(4):736-745. Fuhrmann A, Banisadr A, Beri P, Tlsty TD, Engler AJ. PMID: 28256233.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    5. SOX2, OCT3/4 and NANOG expression and cellular plasticity in rare human somatic cells requires CD73. Cell Signal. 2016 12; 28(12):1923-1932. Pan D, Roy S, Gascard P, Zhao J, Chen-Tanyolac C, Tlsty TD. PMID: 27705752.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    6. Risk prediction for local versus regional/metastatic tumors after initial ductal carcinoma in situ diagnosis treated by lumpectomy. Breast Cancer Res Treat. 2016 06; 157(2):351-361. Molinaro AM, Sison JD, Ljung BM, Tlsty TD, Kerlikowske K. PMID: 27146587.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    7. Carcinoma-associated fibroblasts: orchestrating the composition of malignancy. Genes Dev. 2016 05 01; 30(9):1002-19. Gascard P, Tlsty TD. PMID: 27151975.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    8. Novel insights from 3D models: the pivotal role of physical symmetry in epithelial organization. Sci Rep. 2015 Oct 16; 5:15153. Kurup A, Ravindranath S, Tran T, Keating M, Gascard P, Valdevit L, Tlsty TD, Botvinick EL. PMID: 26472542.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    9. Towards aspirin-inspired self-immolating molecules which target the cyclooxygenases. Org Biomol Chem. 2015 Dec 07; 13(45):11078-86. Drake CR, Estévez-Salmerón L, Gascard P, Shen Y, Tlsty TD, Jones EF. PMID: 26400105.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    10. Integrative analysis of 111 reference human epigenomes. Nature. 2015 Feb 19; 518(7539):317-30. Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon G, Sandstrom RS, Eaton ML, Wu YC, Pfenning AR, Wang X, Claussnitzer M, Liu Y, Coarfa C, Harris RA, Shoresh N, Epstein CB, Gjoneska E, Leung D, Xie W, Hawkins RD, Lister R, Hong C, Gascard P, Mungall AJ, Moore R, Chuah E, Tam A, Canfield TK, Hansen RS, Kaul R, Sabo PJ, Bansal MS, Carles A, Dixon JR, Farh KH, Feizi S, Karlic R, Kim AR, Kulkarni A, Li D, Lowdon R, Elliott G, Mercer TR, Neph SJ, Onuchic V, Polak P, Rajagopal N, Ray P, Sallari RC, Siebenthall KT, Sinnott-Armstrong NA, Stevens M, Thurman RE, Wu J, Zhang B, Zhou X, Beaudet AE, Boyer LA, De Jager PL, Farnham PJ, Fisher SJ, Haussler D, Jones SJ, Li W, Marra MA, McManus MT, Sunyaev S, Thomson JA, Tlsty TD, Tsai LH, Wang W, Waterland RA, Zhang MQ, Chadwick LH, Bernstein BE, Costello JF, Ecker JR, Hirst M, Meissner A, Milosavljevic A, Ren B, Stamatoyannopoulos JA, Wang T, Kellis M. PMID: 25693563.
      View in: PubMed   Mentions: 1291     Fields:    Translation:HumansCells
    11. Epigenetic and transcriptional determinants of the human breast. Nat Commun. 2015 Feb 18; 6:6351. Gascard P, Bilenky M, Sigaroudinia M, Zhao J, Li L, Carles A, Delaney A, Tam A, Kamoh B, Cho S, Griffith M, Chu A, Robertson G, Cheung D, Li I, Heravi-Moussavi A, Moksa M, Mingay M, Hussainkhel A, Davis B, Nagarajan RP, Hong C, Echipare L, O'Geen H, Hangauer MJ, Cheng JB, Neel D, Hu D, McManus MT, Moore R, Mungall A, Ma Y, Plettner P, Ziv E, Wang T, Farnham PJ, Jones SJ, Marra MA, Tlsty TD, Costello JF, Hirst M. PMID: 25690954.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    12. Intermediate DNA methylation is a conserved signature of genome regulation. Nat Commun. 2015 Feb 18; 6:6363. Elliott G, Hong C, Xing X, Zhou X, Li D, Coarfa C, Bell RJ, Maire CL, Ligon KL, Sigaroudinia M, Gascard P, Tlsty TD, Harris RA, Schalkwyk LC, Bilenky M, Mill J, Farnham PJ, Kellis M, Marra MA, Milosavljevic A, Hirst M, Stormo GD, Wang T, Costello JF. PMID: 25691127.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    13. Regulatory network decoded from epigenomes of surface ectoderm-derived cell types. Nat Commun. 2014 Nov 25; 5:5442. Lowdon RF, Zhang B, Bilenky M, Mauro T, Li D, Gascard P, Sigaroudinia M, Farnham PJ, Bastian BC, Tlsty TD, Marra MA, Hirst M, Costello JF, Wang T, Cheng JB. PMID: 25421844.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    14. Stress signaling from human mammary epithelial cells contributes to phenotypes of mammographic density. Cancer Res. 2014 Sep 15; 74(18):5032-5044. DeFilippis RA, Fordyce C, Patten K, Chang H, Zhao J, Fontenay GV, Kerlikowske K, Parvin B, Tlsty TD. PMID: 25172842.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    15. Game theory in the death galaxy: interaction of cancer and stromal cells in tumour microenvironment. Interface Focus. 2014 Aug 06; 4(4):20140028. Wu A, Liao D, Tlsty TD, Sturm JC, Austin RH. PMID: 25097749.
      View in: PubMed   Mentions:
    16. Evolutionary game theory for physical and biological scientists. I. Training and validating population dynamics equations. Interface Focus. 2014 Aug 06; 4(4):20140037. Liao D, Tlsty TD. PMID: 25097751.
      View in: PubMed   Mentions:
    17. Evolutionary game theory for physical and biological scientists. II. Population dynamics equations can be associated with interpretations. Interface Focus. 2014 Aug 06; 4(4):20140038. Liao D, Tlsty TD. PMID: 25097752.
      View in: PubMed   Mentions:
    18. Cell motility and drug gradients in the emergence of resistance to chemotherapy. Proc Natl Acad Sci U S A. 2013 Oct 01; 110(40):16103-8. Wu A, Loutherback K, Lambert G, Estévez-Salmerón L, Tlsty TD, Austin RH, Sturm JC. PMID: 24046372.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    19. Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm. Genome Res. 2013 Sep; 23(9):1522-40. Zhang B, Zhou Y, Lin N, Lowdon RF, Hong C, Nagarajan RP, Cheng JB, Li D, Stevens M, Lee HJ, Xing X, Zhou J, Sundaram V, Elliott G, Gu J, Shi T, Gascard P, Sigaroudinia M, Tlsty TD, Kadlecek T, Weiss A, O'Geen H, Farnham PJ, Maire CL, Ligon KL, Madden PA, Tam A, Moore R, Hirst M, Marra MA, Zhang B, Costello JF, Wang T. PMID: 23804400.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    20. DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape. Nat Genet. 2013 Jul; 45(7):836-41. Xie M, Hong C, Zhang B, Lowdon RF, Xing X, Li D, Zhou X, Lee HJ, Maire CL, Ligon KL, Gascard P, Sigaroudinia M, Tlsty TD, Kadlecek T, Weiss A, O'Geen H, Farnham PJ, Madden PA, Mungall AJ, Tam A, Kamoh B, Cho S, Moore R, Hirst M, Marra MA, Costello JF, Wang T. PMID: 23708189.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansCells
    21. Coordinate transcriptional and translational repression of p53 by TGF-ß1 impairs the stress response. Mol Cell. 2013 May 23; 50(4):552-64. López-Díaz FJ, Gascard P, Balakrishnan SK, Zhao J, Del Rincon SV, Spruck C, Tlsty TD, Emerson BM. PMID: 23706820.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    22. Rare somatic cells from human breast tissue exhibit extensive lineage plasticity. Proc Natl Acad Sci U S A. 2013 Mar 19; 110(12):4598-603. Roy S, Gascard P, Dumont N, Zhao J, Pan D, Petrie S, Margeta M, Tlsty TD. PMID: 23487770.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCellsCTClinical Trials
    23. Breast fibroblasts modulate early dissemination, tumorigenesis, and metastasis through alteration of extracellular matrix characteristics. Neoplasia. 2013 Mar; 15(3):249-62. Dumont N, Liu B, Defilippis RA, Chang H, Rabban JT, Karnezis AN, Tjoe JA, Marx J, Parvin B, Tlsty TD. PMID: 23479504.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    24. A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep. 2013; 3:1449. Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH. PMID: 23618955.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    25. Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes. Breast Cancer Res. 2012 Dec 07; 14(6):R155. Fordyce CA, Patten KT, Fessenden TB, DeFilippis R, Hwang ES, Zhao J, Tlsty TD. PMID: 23216814.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    26. Hello out there...is anybody listening? Cancer Discov. 2012 Dec; 2(12):1084-6. DeFilippis RA, Tlsty TD. PMID: 23230186.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    27. Generalized principles of stochasticity can be used to control dynamic heterogeneity. Phys Biol. 2012 Dec; 9(6):065006. Liao D, Estévez-Salmerón L, Tlsty TD. PMID: 23197162.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    28. Conceptualizing a tool to optimize therapy based on dynamic heterogeneity. Phys Biol. 2012 Dec; 9(6):065005. Liao D, Estévez-Salmerón L, Tlsty TD. PMID: 23197078.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    29. CD36 repression activates a multicellular stromal program shared by high mammographic density and tumor tissues. Cancer Discov. 2012 Sep; 2(9):826-39. DeFilippis RA, Chang H, Dumont N, Rabban JT, Chen YY, Fontenay GV, Berman HK, Gauthier ML, Zhao J, Hu D, Marx JJ, Tjoe JA, Ziv E, Febbraio M, Kerlikowske K, Parvin B, Tlsty TD. PMID: 22777768.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    30. The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature. 2012 Apr 04; 486(7403):395-9. Shah SP, Roth A, Goya R, Oloumi A, Ha G, Zhao Y, Turashvili G, Ding J, Tse K, Haffari G, Bashashati A, Prentice LM, Khattra J, Burleigh A, Yap D, Bernard V, McPherson A, Shumansky K, Crisan A, Giuliany R, Heravi-Moussavi A, Rosner J, Lai D, Birol I, Varhol R, Tam A, Dhalla N, Zeng T, Ma K, Chan SK, Griffith M, Moradian A, Cheng SW, Morin GB, Watson P, Gelmon K, Chia S, Chin SF, Curtis C, Rueda OM, Pharoah PD, Damaraju S, Mackey J, Hoon K, Harkins T, Tadigotla V, Sigaroudinia M, Gascard P, Tlsty T, Costello JF, Meyer IM, Eaves CJ, Wasserman WW, Jones S, Huntsman D, Hirst M, Caldas C, Marra MA, Aparicio S. PMID: 22495314.
      View in: PubMed   Mentions: 634     Fields:    Translation:HumansCells
    31. p16(INK4a) expression and breast cancer risk in women with atypical hyperplasia. Cancer Prev Res (Phila). 2011 Dec; 4(12):1953-60. Radisky DC, Santisteban M, Berman HK, Gauthier ML, Frost MH, Reynolds CA, Vierkant RA, Pankratz VS, Visscher DW, Tlsty TD, Hartmann LC. PMID: 21920875.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    32. Tissue states provide novel insights into attributes that drive metastasis. Cancer Cell. 2011 Sep 13; 20(3):285-6. Tlsty TD. PMID: 21907919.
      View in: PubMed   Mentions:    Fields:    
    33. Tumor microenvironment and progression. J Surg Oncol. 2011 May 01; 103(6):468-74. Dvorak HF, Weaver VM, Tlsty TD, Bergers G. PMID: 21480238.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    34. An analogy between the evolution of drug resistance in bacterial communities and malignant tissues. Nat Rev Cancer. 2011 05; 11(5):375-82. Lambert G, Estévez-Salmeron L, Oh S, Liao D, Emerson BM, Tlsty TD, Austin RH. PMID: 21508974.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    35. A twist of cell fate. Cell Stem Cell. 2011 Feb 04; 8(2):126-7. Tlsty TD. PMID: 21295267.
      View in: PubMed   Mentions: 2     Fields:    
    36. Biomarker expression and risk of subsequent tumors after initial ductal carcinoma in situ diagnosis. J Natl Cancer Inst. 2010 May 05; 102(9):627-37. Kerlikowske K, Molinaro AM, Gauthier ML, Berman HK, Waldman F, Bennington J, Sanchez H, Jimenez C, Stewart K, Chew K, Ljung BM, Tlsty TD. PMID: 20427430.
      View in: PubMed   Mentions: 102     Fields:    Translation:Humans
    37. Premalignant breast neoplasia: a paradigm of interlesional and intralesional molecular heterogeneity and its biological and clinical ramifications. Cancer Prev Res (Phila). 2010 May; 3(5):579-87. Berman HK, Gauthier ML, Tlsty TD. PMID: 20424132.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    38. Primary cilia regulate branching morphogenesis during mammary gland development. Curr Biol. 2010 Apr 27; 20(8):731-7. McDermott KM, Liu BY, Tlsty TD, Pazour GJ. PMID: 20381354.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    39. Unprecedented opportunities and promise for cancer prevention research. Cancer Prev Res (Phila). 2010 Apr; 3(4):394-402. Blackburn EH, Tlsty TD, Lippman SM. PMID: 20354163.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    40. DNA damage drives an activin a-dependent induction of cyclooxygenase-2 in premalignant cells and lesions. Cancer Prev Res (Phila). 2010 Feb; 3(2):190-201. Fordyce C, Fessenden T, Pickering C, Jung J, Singla V, Berman H, Tlsty T. PMID: 20028875.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    41. Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy. Breast Cancer Res. 2009; 11(6):R87. Dumont N, Crawford YG, Sigaroudinia M, Nagrani SS, Wilson MB, Buehring GC, Turashvili G, Aparicio S, Gauthier ML, Fordyce CA, McDermott KM, Tlsty TD. PMID: 19995452.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    42. Reflections on miR-ing effects in metastasis. Cancer Cell. 2009 Jul 07; 16(1):3-4. Dumont N, Tlsty TD. PMID: 19573805.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    43. Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers. Proc Natl Acad Sci U S A. 2008 Sep 30; 105(39):14867-72. Dumont N, Wilson MB, Crawford YG, Reynolds PA, Sigaroudinia M, Tlsty TD. PMID: 18806226.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansCells
    44. Graphical methods for quantifying macromolecules through bright field imaging. Bioinformatics. 2009 Apr 15; 25(8):1070-5. Chang H, DeFilippis RA, Tlsty TD, Parvin B. PMID: 18703588.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    45. Cancer: whispering sweet somethings. Nature. 2008 May 29; 453(7195):604-5. Tlsty T. PMID: 18509432.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    46. Morphologically normal-appearing mammary epithelial cells obtained from high-risk women exhibit methylation silencing of INK4a/ARF. Clin Cancer Res. 2007 Nov 15; 13(22 Pt 1):6834-41. Bean GR, Bryson AD, Pilie PG, Goldenberg V, Baker JC, Ibarra C, Brander DM, Paisie C, Case NR, Gauthier M, Reynolds PA, Dietze E, Ostrander J, Scott V, Wilke LG, Yee L, Kimler BF, Fabian CJ, Zalles CM, Broadwater G, Tlsty TD, Seewaldt VL. PMID: 18006786.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    47. Abrogated response to cellular stress identifies DCIS associated with subsequent tumor events and defines basal-like breast tumors. Cancer Cell. 2007 Nov; 12(5):479-91. Gauthier ML, Berman HK, Miller C, Kozakeiwicz K, Chew K, Moore D, Rabban J, Chen YY, Kerlikowske K, Tlsty TD. PMID: 17996651.
      View in: PubMed   Mentions: 86     Fields:    Translation:Humans
    48. Stratification of breast cancer risk in women with atypia: a Mayo cohort study. J Clin Oncol. 2007 Jul 01; 25(19):2671-7. Degnim AC, Visscher DW, Berman HK, Frost MH, Sellers TA, Vierkant RA, Maloney SD, Pankratz VS, de Groen PC, Lingle WL, Ghosh K, Penheiter L, Tlsty T, Melton LJ, Reynolds CA, Hartmann LC. PMID: 17563394.
      View in: PubMed   Mentions: 59     Fields:    Translation:Humans
    49. Inactivation of p53 function in cultured human mammary epithelial cells turns the telomere-length dependent senescence barrier from agonescence into crisis. Cell Cycle. 2007 Aug 01; 6(15):1927-36. Garbe JC, Holst CR, Bassett E, Tlsty T, Stampfer MR. PMID: 17671422.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    50. Luminal cells GATA have it. Nat Cell Biol. 2007 Feb; 9(2):135-6. Tlsty TD. PMID: 17268476.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    51. p16INK4a modulates p53 in primary human mammary epithelial cells. Cancer Res. 2006 Nov 01; 66(21):10325-31. Zhang J, Pickering CR, Holst CR, Gauthier ML, Tlsty TD. PMID: 17079452.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    52. Simulating properties of in vitro epithelial cell morphogenesis. PLoS Comput Biol. 2006 Oct 06; 2(10):e129. Grant MR, Mostov KE, Tlsty TD, Hunt CA. PMID: 17029556.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    53. Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells. J Biol Chem. 2006 Aug 25; 281(34):24790-802. Reynolds PA, Sigaroudinia M, Zardo G, Wilson MB, Benton GM, Miller CJ, Hong C, Fridlyand J, Costello JF, Tlsty TD. PMID: 16766534.
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    54. p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells. PLoS Biol. 2006 Mar; 4(3):e51. McDermott KM, Zhang J, Holst CR, Kozakiewicz BK, Singla V, Tlsty TD. PMID: 16464125.
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    55. Tumor stroma and regulation of cancer development. Annu Rev Pathol. 2006; 1:119-50. Tlsty TD, Coussens LM. PMID: 18039110.
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    56. Benign breast disease and the risk of breast cancer. N Engl J Med. 2005 Jul 21; 353(3):229-37. Hartmann LC, Sellers TA, Frost MH, Lingle WL, Degnim AC, Ghosh K, Vierkant RA, Maloney SD, Pankratz VS, Hillman DW, Suman VJ, Johnson J, Blake C, Tlsty T, Vachon CM, Melton LJ, Visscher DW. PMID: 16034008.
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    57. p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue. Cancer Res. 2005 Mar 01; 65(5):1792-9. Gauthier ML, Pickering CR, Miller CJ, Fordyce CA, Chew KL, Berman HK, Tlsty TD. PMID: 15753376.
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    58. Genetic and epigenetic changes in mammary epithelial cells identify a subpopulation of cells involved in early carcinogenesis. Cold Spring Harb Symp Quant Biol. 2005; 70:317-27. Berman H, Zhang J, Crawford YG, Gauthier ML, Fordyce CA, McDermott KM, Sigaroudinia M, Kozakiewicz K, Tlsty TD. PMID: 16869768.
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    59. Genetic and epigenetic changes in mammary epithelial cells may mimic early events in carcinogenesis. J Mammary Gland Biol Neoplasia. 2004 Jul; 9(3):263-74. Tlsty TD, Crawford YG, Holst CR, Fordyce CA, Zhang J, McDermott K, Kozakiewicz K, Gauthier ML. PMID: 15557799.
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    60. Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program. Cancer Cell. 2004 Mar; 5(3):263-73. Crawford YG, Gauthier ML, Joubel A, Mantei K, Kozakiewicz K, Afshari CA, Tlsty TD. PMID: 15050918.
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    61. Cyclooxygenase-2 expression is related to nuclear grade in ductal carcinoma in situ and is increased in its normal adjacent epithelium. Cancer Res. 2003 May 15; 63(10):2347-50. Shim V, Gauthier ML, Sudilovsky D, Mantei K, Chew KL, Moore DH, Cha I, Tlsty TD, Esserman LJ. PMID: 12750248.
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    62. Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia. Cancer Res. 2003 Apr 01; 63(7):1596-601. Holst CR, Nuovo GJ, Esteller M, Chew K, Baylin SB, Herman JG, Tlsty TD. PMID: 12670910.
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    63. Functions of p53 suppress critical consequences of damage and repair in the initiation of cancer. Cancer Cell. 2002 Jul; 2(1):2-4. Tlsty TD. PMID: 12150817.
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    64. Induction of tubulogenesis in telomerase-immortalized human microvascular endothelial cells by glioblastoma cells. Exp Cell Res. 2002 Feb 01; 273(1):21-33. Venetsanakos E, Mirza A, Fanton C, Romanov SR, Tlsty T, McMahon M. PMID: 11795943.
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    65. Minichromosome maintenance protein 2 expression in prostate: characterization and association with outcome after therapy for cancer. Clin Cancer Res. 2001 Sep; 7(9):2712-8. Meng MV, Grossfeld GD, Williams GH, Dilworth S, Stoeber K, Mulley TW, Weinberg V, Carroll PR, Tlsty TD. PMID: 11555583.
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    66. DNA replication licensing and human cell proliferation. J Cell Sci. 2001 Jun; 114(Pt 11):2027-41. Stoeber K, Tlsty TD, Happerfield L, Thomas GA, Romanov S, Bobrow L, Williams ED, Williams GH. PMID: 11493639.
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    67. Stromal cells can contribute oncogenic signals. Semin Cancer Biol. 2001 Apr; 11(2):97-104. Tlsty TD. PMID: 11322829.
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    68. Loss of chromosomal integrity in human mammary epithelial cells subsequent to escape from senescence. J Mammary Gland Biol Neoplasia. 2001 Apr; 6(2):235-43. Tlsty TD, Romanov SR, Kozakiewicz BK, Holst CR, Haupt LM, Crawford YG. PMID: 11501583.
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    69. Know thy neighbor: stromal cells can contribute oncogenic signals. Curr Opin Genet Dev. 2001 Feb; 11(1):54-9. Tlsty TD, Hein PW. PMID: 11163151.
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    70. Searching for targets: the power of somatic cell genetics. Genome Res. 2001 Feb; 11(2):187-8. Tlsty TD. PMID: 11157780.
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    71. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes. Nature. 2001 Feb 01; 409(6820):633-7. Romanov SR, Kozakiewicz BK, Holst CR, Stampfer MR, Haupt LM, Tlsty TD. PMID: 11214324.
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    72. Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts. Proc Natl Acad Sci U S A. 2000 Sep 12; 97(19):10544-8. Felsher DW, Zetterberg A, Zhu J, Tlsty T, Bishop JM. PMID: 10962037.
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    73. Human mammary epithelial cells exhibit a differential p53-mediated response following exposure to ionizing radiation or UV light. Oncogene. 1999 Oct 14; 18(42):5795-805. Meyer KM, Hess SM, Tlsty TD, Leadon SA. PMID: 10523860.
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    74. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res. 1999 Oct 01; 59(19):5002-11. Olumi AF, Grossfeld GD, Hayward SW, Carroll PR, Tlsty TD, Cunha GR. PMID: 10519415.
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    75. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat Genet. 1999 Jan; 21(1):111-4. Jiang XR, Jimenez G, Chang E, Frolkis M, Kusler B, Sage M, Beeche M, Bodnar AG, Wahl GM, Tlsty TD, Chiu CP. PMID: 9916802.
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    76. A molecular blueprint for targeting cancer? Nat Genet. 1999 Jan; 21(1):64-5. Tlsty TD. PMID: 9916789.
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    77. A novel coculture technique demonstrates that normal human prostatic fibroblasts contribute to tumor formation of LNCaP cells by retarding cell death. Cancer Res. 1998 Oct 15; 58(20):4525-30. Olumi AF, Dazin P, Tlsty TD. PMID: 9788594.
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    78. Cell-adhesion-dependent influences on genomic instability and carcinogenesis. Curr Opin Cell Biol. 1998 Oct; 10(5):647-53. Tlsty TD. PMID: 9818176.
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    79. Genetic and epigenetic influences in prostatic carcinogenesis (review). Int J Oncol. 1998 Jul; 13(1):35-47. Hayward SW, Grossfeld GD, Tlsty TD, Cunha GR. PMID: 9625801.
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    80. Attenuation of G1 checkpoint function by the non-genotoxic carcinogen phenobarbital. Carcinogenesis. 1998 Jul; 19(7):1173-83. Gonzales AJ, Christensen JG, Preston RJ, Goldsworthy TL, Tlsty TD, Fox TR. PMID: 9683175.
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    81. An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control. Proc Natl Acad Sci U S A. 1998 Apr 28; 95(9):5166-71. Gualberto A, Aldape K, Kozakiewicz K, Tlsty TD. PMID: 9560247.
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    82. Identification of additional complementation groups that regulate genomic instability. Genes Chromosomes Cancer. 1997 Oct; 20(2):103-12. Hall IJ, Gioeli D, Weissman BE, Tlsty TD. PMID: 9331561.
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    83. Cellular adhesion regulates p53 protein levels in primary human keratinocytes. Cancer Res. 1997 Sep 01; 57(17):3635-9. Nigro JM, Aldape KD, Hess SM, Tlsty TD. PMID: 9288761.
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    84. Genomic instability and its role in neoplasia. Curr Top Microbiol Immunol. 1997; 221:37-46. Tlsty TD. PMID: 8979439.
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    85. Separate pathways for p53 induction by ionizing radiation and N-(phosphonoacetyl)-L-aspartate. Cancer Res. 1996 Aug 15; 56(16):3659-62. Chen CY, Hall I, Lansing TJ, Gilmer TM, Tlsty TD, Kastan MB. PMID: 8706003.
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    86. Alteration of cell cycle kinase complexes in human papillomavirus E6- and E7-expressing fibroblasts precedes neoplastic transformation. J Virol. 1996 Feb; 70(2):999-1008. Xiong Y, Kuppuswamy D, Li Y, Livanos EM, Hixon M, White A, Beach D, Tlsty TD. PMID: 8551641.
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    87. Regulation of genomic instability in preneoplastic cells. Cancer Surv. 1996; 28:217-24. Tlsty TD. PMID: 8977037.
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    88. Genomic instability and cancer. Mutat Res. 1995 Jul; 337(1):1-7. Tlsty TD, Briot A, Gualberto A, Hall I, Hess S, Hixon M, Kuppuswamy D, Romanov S, Sage M, White A. PMID: 7596354.
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    89. Defective G2 checkpoint function in cells from individuals with familial cancer syndromes. Cancer Res. 1995 Apr 15; 55(8):1763-73. Paules RS, Levedakou EN, Wilson SJ, Innes CL, Rhodes N, Tlsty TD, Galloway DA, Donehower LA, Tainsky MA, Kaufmann WK. PMID: 7712486.
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    90. Analysis of cell cycle checkpoint status in mammalian cells. Methods Enzymol. 1995; 254:125-33. Tlsty T, Briot A, Poulose B. PMID: 8531681.
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    91. Clonal variation of tumorigenic potential in v-Ha-ras-transformed human bronchial epithelial cells: relationship to ras oncogene expression and CAD gene amplification. Mol Carcinog. 1994 Sep; 11(1):34-41. Forrester K, Kispert J, Sanchez JH, Gerwin BI, Tlsty TD, Harris CC. PMID: 7916988.
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    92. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell. 1994 Mar 25; 76(6):1013-23. Dulic V, Kaufmann WK, Wilson SJ, Tlsty TD, Lees E, Harper JW, Elledge SJ, Reed SI. PMID: 8137420.
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    93. Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins. Genes Dev. 1994 Mar 15; 8(6):666-77. White AE, Livanos EM, Tlsty TD. PMID: 7926757.
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    94. Genomic integrity and the genetics of cancer. Cold Spring Harb Symp Quant Biol. 1994; 59:265-75. Tlsty TD, White A, Livanos E, Sage M, Roelofs H, Briot A, Poulose B. PMID: 7587078.
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    95. Multiple mechanisms of N-(phosphonoacetyl)-L-aspartate drug resistance in SV40-infected precrisis human fibroblasts. Cancer Res. 1993 Oct 15; 53(20):4946-51. Schaefer DI, Livanos EM, White AE, Tlsty TD. PMID: 8402685.
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    96. Amplification potential in preneoplastic and neoplastic Syrian hamster embryo fibroblasts transformed by various carcinogens. Cancer Res. 1993 Jul 01; 53(13):3098-102. Jonczyk P, White A, Lum K, Barrett JC, Tlsty TD. PMID: 8319217.
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    97. Loss of chromosomal integrity in neoplasia. Cold Spring Harb Symp Quant Biol. 1993; 58:645-54. Tlsty TD, Jonczyk P, White A, Sage M, Hall I, Schaefer D, Briot A, Livanos E, Roelofs H, Poulose B. PMID: 7956081.
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    98. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell. 1992 Sep 18; 70(6):923-35. Livingstone LR, White A, Sprouse J, Livanos E, Jacks T, Tlsty TD. PMID: 1356076.
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    99. Suppression of gene amplification in human cell hybrids. Science. 1992 Mar 13; 255(5050):1425-7. Tlsty TD, White A, Sanchez J. PMID: 1542791.
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    100. Replication of the dihydrofolate reductase genes on double minute chromosomes in a murine cell line. Exp Cell Res. 1990 May; 188(1):164-8. Tlsty TD, Adams P. PMID: 2328775.
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    101. Normal diploid human and rodent cells lack a detectable frequency of gene amplification. Proc Natl Acad Sci U S A. 1990 Apr; 87(8):3132-6. Tlsty TD. PMID: 2326271.
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    102. Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbrück fluctuation analysis. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9441-5. Tlsty TD, Margolin BH, Lum K. PMID: 2687881.
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    103. 1-beta-D-arabinofuranosylcytosine enhancement of resistance to several antineoplastic drugs in mammalian tissue culture cells. Mol Pharmacol. 1989 Sep; 36(3):360-5. Goz B, Carl PL, Tlsty TD. PMID: 2571071.
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    104. Increased incidence of CAD gene amplification in tumorigenic rat lines as an indicator of genomic instability of neoplastic cells. J Biol Chem. 1989 Feb 25; 264(6):3390-6. Otto E, McCord S, Tlsty TD. PMID: 2914957.
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    105. Rapid emergence of methotrexate resistance in cultured mouse cells. Cancer Res. 1984 Aug; 44(8):3303-6. Rath H, Tlsty T, Schimke RT. PMID: 6744265.
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    106. UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells. Mol Cell Biol. 1984 Jun; 4(6):1050-6. Tlsty TD, Brown PC, Schimke RT. PMID: 6738530.
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    107. Gene amplification in the lac region of E. coli. Cell. 1984 May; 37(1):217-24. Tlsty TD, Albertini AM, Miller JH. PMID: 6327052.
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    108. Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea. Mol Cell Biol. 1983 Jun; 3(6):1097-107. Brown PC, Tlsty TD, Schimke RT. PMID: 6877240.
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    109. Analysis of spontaneous deletions and gene amplification in the lac region of Escherichia coli. Cold Spring Harb Symp Quant Biol. 1983; 47 Pt 2:841-50. Albertini AM, Hofer M, Calos MP, Tlsty TD, Miller JH. PMID: 6345079.
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    110. Insertion, excision, and inversion of Tn5. Cold Spring Harb Symp Quant Biol. 1981; 45 Pt 1:115-23. Berg DE, Egner C, Hirschel BJ, Howard J, Johnsrud L, Jorgensen RA, Tlsty TD. PMID: 6271454.
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    111. The distribution of DNA repair synthesis in chromatin and its rearrangement following damage with N-acetoxy-2-acetylaminofluorene. Nucleic Acids Res. 1978 Sep; 5(9):3261-73. Tlsty TD, Lieberman MW. PMID: 704356.
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    112. Distribution of ultraviolet-induced DNA repair synthesis in nuclease sensitive and resistant regions of human chromatin. Biochemistry. 1978 Jun 13; 17(12):2377-86. Smerdon MJ, Tlsty TD, Lieberman MW. PMID: 678515.
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    113. The inhibition of ribosomal RNA synthesis and maturation in Novikoff hepatoma cells by 5-fluorouridine. Cancer Res. 1975 Nov; 35(11 Pt 1):3014-20. Wilkinson DS, Tlsty TD, Hanas RJ. PMID: 171060.
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