Jonathan Chou, MD, PhD

Title(s)Adjunct Instructor, Medicine
SchoolSchool of Medicine
AddressLocation Required
Varies CA 00000
Phone415-476-1528
ORCID ORCID Icon0000-0003-1258-0391 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Stanford University, Stanford, CABS06/2005Biological Sciences, Chemistry
    UCSF, San Francisco, CAPhD09/2012Biomedical Sciences
    UCSF, San Francisco, CAMD06/2014Medicine
    UCSF, San Francisco, CA06/2016Resident, Internal Medicine
    UCSF, San Francisco, CA06/2020Fellowship, Medical Oncology
    Collapse Awards and Honors
    Prostate Cancer Foundation2020Young Investigator Award
    Department of Defense, Prostate Cancer Research Program2019Physician Research Award
    A.P. Giannini Foundation2018A.P. Giannini Postdoctoral Fellow
    UCSF, Division of Hematology/Oncology2018Rosenberg Fellowship in Genitourinary Oncology
    UCSF, Division of Hematology/Oncology2017Clinical Fellow Award
    UCSF, Helen Diller Cancer Center2017T32 Fellow in Molecular and Cellular Mechanisms of Cancer
    UCSF, Division of Hematology/Oncology2017Quinlan Fellowship in Genitourinary Oncology
    UCSF Breast Oncology Retreat2014Poster Winner
    American Society of Cell Biology Annual Meeting - SF2013Invited Mini-Symposium Speaker - Cancer Cell Biology
    Department of Defense, Breast Cancer Research Program2010Pre-doctoral Fellowship
    California Breast Cancer Research Program2009Pre-doctoral Fellowship
    Stanford University2006Dean's Award for Academic Accomplishment
    Stanford University2006Firestone Medal for Undergraduate Thesis
    Goldwater Foundation2003Goldwater Scholar

    Collapse Overview 
    Collapse Overview
    I am a physician-scientist broadly interested in translational oncology and am currently an Instructor in the Division of Hematology/Oncology and postdoctoral research fellow in the Feng Lab (http://fenglaboratory.com/) and Ashworth Lab. My research interests include investigating the role of CDK12 in prostate cancer, understanding mechanisms of therapeutic resistance, and identifying novel targets to better treat genitourinary malignancies. I completed my PhD dissertation with the late Dr. Zena Werb, and studied transcriptional regulation of metastasis and the tumor microenvironment.

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Heterogeneity in NECTIN4 expression across molecular subtypes of urothelial cancer mediates sensitivity to enfortumab vedotin. Clin Cancer Res. 2021 Jun 09. Chu CE, Sjöström M, Egusa EA, Gibb EA, Badura ML, Zhu J, Koshkin VS, Stohr BA, Meng MV, Pruthi RS, Friedlander TW, Lotan Y, Black PC, Porten SP, Feng FY, Chou J. PMID: 34108177.
      View in: PubMed   Mentions: 1     Fields:    
    2. TERT promoter mutations and other prognostic factors in patients with advanced urothelial carcinoma treated with an immune checkpoint inhibitor. J Immunother Cancer. 2021 May; 9(5). de Kouchkovsky I, Zhang L, Philip EJ, Wright F, Kim DM, Natesan D, Kwon D, Ho H, Ho S, Chan E, Porten SP, Wong AC, Desai A, Huang FW, Chou J, Oh DY, Pruthi RS, Fong L, Small EJ, Friedlander TW, Koshkin V. PMID: 33980590.
      View in: PubMed   Mentions:    Fields:    
    3. Prostate-specific Membrane Antigen and Fluciclovine Transporter Genes are Associated with Variable Clinical Features and Molecular Subtypes of Primary Prostate Cancer. Eur Urol. 2021 Jun; 79(6):717-721. Chu CE, Alshalalfa M, Sjöström M, Zhao SG, Liu Y, Chou J, Herlemann A, Mahal B, Kishan AU, Spratt DE, Cooperberg M, Small E, Wong A, Porten S, Hope TA, Ross AE, Davicioni E, Nguyen P, Karnes RJ, Carroll PR, Schaeffer E, Feng FY. PMID: 33840559.
      View in: PubMed   Mentions:    Fields:    
    4. Differential treatment outcomes in BRCA1/2-, CDK12-, and ATM-mutated metastatic castration-resistant prostate cancer. Cancer. 2021 Jun 15; 127(12):1965-1973. Kwon DH, Chou J, Yip SM, Reimers MA, Zhang L, Wright F, Dhawan MS, Borno HT, Desai A, Aggarwal RR, Wyatt AW, Small EJ, Alva AS, Chi KN, Feng FY, Koshkin VS. PMID: 33690902.
      View in: PubMed   Mentions:    Fields:    
    5. Molecular Imaging of Prostate Cancer Targeting CD46 Using ImmunoPET. Clin Cancer Res. 2021 Mar 01; 27(5):1305-1315. Wang S, Li J, Hua J, Su Y, Beckford-Vera DR, Zhao W, Jayaraman M, Huynh TL, Zhao N, Wang YH, Huang Y, Qin F, Shen S, Gioeli D, Dreicer R, Sriram R, Egusa EA, Chou J, Feng FY, Aggarwal R, Evans MJ, Seo Y, Liu B, Flavell RR, He J. PMID: 33293372.
      View in: PubMed   Mentions:    Fields:    
    6. Molecular Insights in Transmission of Cancer From an Organ Donor to Four Transplant Recipients. J Natl Compr Canc Netw. 2020 11; 18(11):1446-1452. Atreya CE, Collisson EA, Park M, Grenert JP, Behr SC, Gonzalez A, Chou J, Maisel S, Friedlander TW, Freise CE, Shoji J, Semrad TJ, Van Ziffle J, Chin-Hong P. PMID: 33152701.
      View in: PubMed   Mentions:    Fields:    
    7. Autoantibody Landscape in Patients with Advanced Prostate Cancer. Clin Cancer Res. 2020 12 01; 26(23):6204-6214. Chen WS, Haynes WA, Waitz R, Kamath K, Vega-Crespo A, Shrestha R, Zhang M, Foye A, Baselga Carretero I, Perez Garcilazo I, Zhang M, Zhao SG, Sjöström M, Quigley DA, Chou J, Beer TM, Rettig M, Gleave M, Evans CP, Lara P, Chi KN, Reiter RE, Alumkal JJ, Ashworth A, Aggarwal R, Small EJ, Daugherty PS, Ribas A, Oh DY, Shon JC, Feng FY. PMID: 32967941.
      View in: PubMed   Mentions: 2     Fields:    
    8. The DNA methylation landscape of advanced prostate cancer. Nat Genet. 2020 08; 52(8):778-789. Zhao SG, Chen WS, Li H, Foye A, Zhang M, Sjöström M, Aggarwal R, Playdle D, Liao A, Alumkal JJ, Das R, Chou J, Hua JT, Barnard TJ, Bailey AM, Chow ED, Perry MD, Dang HX, Yang R, Moussavi-Baygi R, Zhang L, Alshalalfa M, Laura Chang S, Houlahan KE, Shiah YJ, Beer TM, Thomas G, Chi KN, Gleave M, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Yvonne Kim M, Fong L, Spratt DE, Morgan TM, Bose R, Huang FW, Li H, Chesner L, Shenoy T, Goodarzi H, Asangani IA, Sandhu S, Lang JM, Mahajan NP, Lara PN, Evans CP, Febbo P, Batzoglou S, Knudsen KE, He HH, Huang J, Zwart W, Costello JF, Luo J, Tomlins SA, Wyatt AW, Dehm SM, Ashworth A, Gilbert LA, Boutros PC, Farh K, Chinnaiyan AM, Maher CA, Small EJ, Quigley DA, Feng FY. PMID: 32661416.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    9. Transcription-Associated Cyclin-Dependent Kinases as Targets and Biomarkers for Cancer Therapy. Cancer Discov. 2020 03; 10(3):351-370. Chou J, Quigley DA, Robinson TM, Feng FY, Ashworth A. PMID: 32071145.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    10. MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy. Life Sci Alliance. 2019 12; 2(6). Owyong M, Chou J, van den Bijgaart RJ, Kong N, Efe G, Maynard C, Talmi-Frank D, Solomonov I, Koopman C, Hadler-Olsen E, Headley M, Lin C, Wang CY, Sagi I, Werb Z, Plaks V. PMID: 31727800.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    11. Clinical Outcomes in Cyclin-dependent Kinase 12 Mutant Advanced Prostate Cancer. Eur Urol. 2020 03; 77(3):333-341. Reimers MA, Yip SM, Zhang L, Cieslik M, Dhawan M, Montgomery B, Wyatt AW, Chi KN, Small EJ, Chinnaiyan AM, Alva AS, Feng FY, Chou J. PMID: 31640893.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    12. DNA-Dependent Protein Kinase Drives Prostate Cancer Progression through Transcriptional Regulation of the Wnt Signaling Pathway. Clin Cancer Res. 2019 09 15; 25(18):5608-5622. Kothari V, Goodwin JF, Zhao SG, Drake JM, Yin Y, Chang SL, Evans JR, Wilder-Romans K, Gabbara K, Dylgjeri E, Chou J, Sun G, Tomlins SA, Mehra R, Hege K, Filvaroff EH, Schaeffer EM, Karnes RJ, Quigley DA, Rathkopf DE, He HH, Speers C, Spratt DE, Gilbert LA, Ashworth A, Chinnaiyan AM, Raj GV, Knudsen KE, Feng FY. PMID: 31266829.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    13. Clinical and Genomic Implications of Luminal and Basal Subtypes Across Carcinomas. Clin Cancer Res. 2019 04 15; 25(8):2450-2457. Zhao SG, Chen WS, Das R, Chang SL, Tomlins SA, Chou J, Quigley DA, Dang HX, Barnard TJ, Mahal BA, Gibb EA, Liu Y, Davicioni E, Duska LR, Posadas EM, Jolly S, Spratt DE, Nguyen PL, Maher CA, Small EJ, Feng FY. PMID: 30573691.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    14. Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer. Cell. 2018 10 18; 175(3):889. Quigley DA, Dang HX, Zhao SG, Lloyd P, Aggarwal R, Alumkal JJ, Foye A, Kothari V, Perry MD, Bailey AM, Playdle D, Barnard TJ, Zhang L, Zhang J, Youngren JF, Cieslik MP, Parolia A, Beer TM, Thomas G, Chi KN, Gleave M, Lack NA, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Ryan CJ, Fong L, Kim W, Friedlander T, Chou J, Li H, Das R, Li H, Moussavi-Baygi R, Goodarzi H, Gilbert LA, Lara PN, Evans CP, Goldstein TC, Stuart JM, Tomlins SA, Spratt DE, Cheetham RK, Cheng DT, Farh K, Gehring JS, Hakenberg J, Liao A, Febbo PG, Shon J, Sickler B, Batzoglou S, Knudsen KE, He HH, Huang J, Wyatt AW, Dehm SM, Ashworth A, Chinnaiyan AM, Maher CA, Small EJ, Feng FY. PMID: 30340047.
      View in: PubMed   Mentions: 23     Fields:    
    15. Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer. Cell. 2018 07 26; 174(3):758-769.e9. Quigley DA, Dang HX, Zhao SG, Lloyd P, Aggarwal R, Alumkal JJ, Foye A, Kothari V, Perry MD, Bailey AM, Playdle D, Barnard TJ, Zhang L, Zhang J, Youngren JF, Cieslik MP, Parolia A, Beer TM, Thomas G, Chi KN, Gleave M, Lack NA, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Ryan CJ, Fong L, Kim W, Friedlander T, Chou J, Li H, Das R, Li H, Moussavi-Baygi R, Goodarzi H, Gilbert LA, Lara PN, Evans CP, Goldstein TC, Stuart JM, Tomlins SA, Spratt DE, Cheetham RK, Cheng DT, Farh K, Gehring JS, Hakenberg J, Liao A, Febbo PG, Shon J, Sickler B, Batzoglou S, Knudsen KE, He HH, Huang J, Wyatt AW, Dehm SM, Ashworth A, Chinnaiyan AM, Maher CA, Small EJ, Feng FY. PMID: 30033370.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansCells
    16. Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer. Cell. 2018 06 14; 173(7):1770-1782.e14. Wu YM, Cieslik M, Lonigro RJ, Vats P, Reimers MA, Cao X, Ning Y, Wang L, Kunju LP, de Sarkar N, Heath EI, Chou J, Feng FY, Nelson PS, de Bono JS, Zou W, Montgomery B, Alva A, PCF/SU2C International Prostate Cancer Dream Team , Robinson DR, Chinnaiyan AM. PMID: 29906450.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    17. Prostate cancer in the era of "Omic" medicine: recognizing the importance of DNA damage repair pathways. Ann Transl Med. 2018 May; 6(9):161. Kornberg Z, Chou J, Feng FY, Ryan CJ. PMID: 29911109.
      View in: PubMed   Mentions:
    18. HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice. Proc Natl Acad Sci U S A. 2018 01 30; 115(5):E992-E1001. Devignes CS, Aslan Y, Brenot A, Devillers A, Schepers K, Fabre S, Chou J, Casbon AJ, Werb Z, Provot S. PMID: 29339479.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    19. GATA3 targets semaphorin 3B in mammary epithelial cells to suppress breast cancer progression and metastasis. Oncogene. 2017 10 05; 36(40):5567-5575. Shahi P, Wang CY, Chou J, Hagerling C, Gonzalez Velozo H, Ruderisch A, Yu Y, Lai MD, Werb Z. PMID: 28581515.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    20. Respiratory Failure in a Woman 8 Months After an Allogeneic Stem Cell Transplant. JAMA Oncol. 2016 Dec 01; 2(12):1651-1652. Chou J, Wallender E, Schwartz BS. PMID: 27559706.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Electrocardiography Evolution in a Woman Presenting With Alcohol Withdrawal Seizures and Cocaine Use. JAMA Intern Med. 2016 05 01; 176(5):693-5. Chou J, Beutler LR, Goldschlager N. PMID: 27019877.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Metalloproteinases: a Functional Pathway for Myeloid Cells. Microbiol Spectr. 2016 04; 4(2). Chou J, Chan MF, Werb Z. PMID: 27227311.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    23. The Transcriptional Repressor ZNF503/Zeppo2 Promotes Mammary Epithelial Cell Proliferation and Enhances Cell Invasion. J Biol Chem. 2015 Feb 06; 290(6):3803-13. Shahi P, Slorach EM, Wang CY, Chou J, Lu A, Ruderisch A, Werb Z. PMID: 25538248.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    24. Remodelling the extracellular matrix in development and disease. Nat Rev Mol Cell Biol. 2014 Dec; 15(12):786-801. Bonnans C, Chou J, Werb Z. PMID: 25415508.
      View in: PubMed   Mentions: 838     Fields:    Translation:HumansAnimalsCells
    25. microRNA-mediated regulation of the tumor microenvironment. . 2013 Oct 15; 12(20):3262-71. Chou J, Shahi P, Werb Z. PMID: 24036551.
      View in: PubMed   Mentions:
    26. GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression. Nat Cell Biol. 2013 Feb; 15(2):201-13. Chou J, Lin JH, Brenot A, Kim JW, Provot S, Werb Z. PMID: 23354167.
      View in: PubMed   Mentions: 166     Fields:    Translation:HumansAnimalsCells
    27. MicroRNAs play a big role in regulating ovarian cancer-associated fibroblasts and the tumor microenvironment. Cancer Discov. 2012 Dec; 2(12):1078-80. Chou J, Werb Z. PMID: 23230184.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    28. The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression. Cancer Discov. 2012 Jul; 2(7):638-51. Littlepage LE, Adler AS, Kouros-Mehr H, Huang G, Chou J, Krig SR, Griffith OL, Korkola JE, Qu K, Lawson DA, Xue Q, Sternlicht MD, Dijkgraaf GJ, Yaswen P, Rugo HS, Sweeney CA, Collins CC, Gray JW, Chang HY, Werb Z. PMID: 22728437.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    29. Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization. Genes Dev. 2011 Mar 01; 25(5):471-84. Slorach EM, Chou J, Werb Z. PMID: 21317240.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    30. GATA3 in development and cancer differentiation: cells GATA have it! J Cell Physiol. 2010 Jan; 222(1):42-9. Chou J, Provot S, Werb Z. PMID: 19798694.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimals
    31. Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival. Nature. 2005 Nov 10; 438(7065):224-8. Allen E, Ding J, Wang W, Pramanik S, Chou J, Yau V, Yang Y. PMID: 16227972.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
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