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Jonathan Chou, MD, PhD

Title(s)CLINIAL FELLOW, Medicine
SchoolSchool of Medicine
Phone415-502-6355
ORCID ORCID Icon0000-0003-1258-0391 Additional info
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    Collapse Biography 
    Collapse Awards and Honors
    A.P. Giannini Foundation2018A.P. Giannini Postdoctoral Fellow
    UCSF, Division of Hematology/Oncology2018Rosenberg Fellowship in Genitourinary Oncology
    UCSF, Division of Hematology/Oncology2017Clinical Fellow Award
    UCSF, Helen Diller Cancer Center2017T32 Fellow in Molecular and Cellular Mechanisms of Cancer
    UCSF, Division of Hematology/Oncology2017Quinlan Fellowship in Genitourinary Oncology
    UCSF Breast Oncology Retreat2014Poster Winner
    American Society of Cell Biology Annual Meeting - SF2013Invited Mini-Symposium Speaker - Cancer Cell Biology
    Department of Defense, Breast Cancer Research Program2010Pre-doctoral Fellowship
    California Breast Cancer Research Program2009Pre-doctoral Fellowship
    Stanford University2006Dean's Award for Academic Accomplishment
    Stanford University2006Firestone Medal for Undergraduate Thesis
    Goldwater Foundation2003Goldwater Scholar

    Collapse Overview 
    Collapse Overview
    BS in Biological Sciences, minor in Chemistry, Stanford University (2005)
    MD, PhD in Biomedical Sciences (MSTP), University of California, San Francisco. Graduate Advisor: Dr. Zena Werb (2006 - 2014)
    Intern, Department of Medicine, University of California, San Francisco (2014-2015)
    Resident, Department of Medicine, University of California, San Francisco (2015 - 2016)
    Clinical Fellow, Division of Hematology/Oncology, University of California, San Francisco (2016 - present). Postdoctoral Advisors: Dr. Felix Feng and Dr. Alan Ashworth.

    I am a physician-scientist broadly interested in translational oncology and am currently a research fellow in the Feng Lab (http://fenglaboratory.com/) and Ashworth Lab. My research interests include understanding cancer metastasis and the tumor microenvironment, investigating mechanisms of therapeutic resistance, and identifying novel targets to better treat genitourinary malignancies.

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Owyong M, Chou J, van den Bijgaart RJ, Kong N, Efe G, Maynard C, Talmi-Frank D, Solomonov I, Koopman C, Hadler-Olsen E, Headley M, Lin C, Wang CY, Sagi I, Werb Z, Plaks V. MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy. Life Sci Alliance. 2019 Dec; 2(6). PMID: 31727800.
      View in: PubMed
    2. Reimers MA, Yip SM, Zhang L, Cieslik M, Dhawan M, Montgomery B, Wyatt AW, Chi KN, Small EJ, Chinnaiyan AM, Alva AS, Feng FY, Chou J. Clinical Outcomes in Cyclin-dependent Kinase 12 Mutant Advanced Prostate Cancer. Eur Urol. 2019 Oct 20. PMID: 31640893.
      View in: PubMed
    3. Kothari V, Goodwin JF, Zhao SG, Drake JM, Yin Y, Chang SL, Evans JR, Wilder-Romans K, Gabbara K, Dylgjeri E, Chou J, Sun G, Tomlins SA, Mehra R, Hege K, Filvaroff EH, Schaeffer EM, Karnes RJ, Quigley DA, Rathkopf DE, He HH, Speers C, Spratt DE, Gilbert LA, Ashworth A, Chinnaiyan AM, Raj GV, Knudsen KE, Feng FY. DNA-Dependent Protein Kinase Drives Prostate Cancer Progression through Transcriptional Regulation of the Wnt Signaling Pathway. Clin Cancer Res. 2019 Sep 15; 25(18):5608-5622. PMID: 31266829.
      View in: PubMed
    4. Zhao SG, Chen WS, Das R, Chang SL, Tomlins SA, Chou J, Quigley DA, Dang HX, Barnard TJ, Mahal BA, Gibb EA, Liu Y, Davicioni E, Duska LR, Posadas EM, Jolly S, Spratt DE, Nguyen PL, Maher CA, Small EJ, Feng FY. Clinical and Genomic Implications of Luminal and Basal Subtypes Across Carcinomas. Clin Cancer Res. 2019 Apr 15; 25(8):2450-2457. PMID: 30573691.
      View in: PubMed
    5. Quigley DA, Dang HX, Zhao SG, Lloyd P, Aggarwal R, Alumkal JJ, Foye A, Kothari V, Perry MD, Bailey AM, Playdle D, Barnard TJ, Zhang L, Zhang J, Youngren JF, Cieslik MP, Parolia A, Beer TM, Thomas G, Chi KN, Gleave M, Lack NA, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Ryan CJ, Fong L, Kim W, Friedlander T, Chou J, Li H, Das R, Li H, Moussavi-Baygi R, Goodarzi H, Gilbert LA, Lara PN, Evans CP, Goldstein TC, Stuart JM, Tomlins SA, Spratt DE, Cheetham RK, Cheng DT, Farh K, Gehring JS, Hakenberg J, Liao A, Febbo PG, Shon J, Sickler B, Batzoglou S, Knudsen KE, He HH, Huang J, Wyatt AW, Dehm SM, Ashworth A, Chinnaiyan AM, Maher CA, Small EJ, Feng FY. Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer. Cell. 2018 10 18; 175(3):889. PMID: 30340047.
      View in: PubMed
    6. Quigley DA, Dang HX, Zhao SG, Lloyd P, Aggarwal R, Alumkal JJ, Foye A, Kothari V, Perry MD, Bailey AM, Playdle D, Barnard TJ, Zhang L, Zhang J, Youngren JF, Cieslik MP, Parolia A, Beer TM, Thomas G, Chi KN, Gleave M, Lack NA, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Ryan CJ, Fong L, Kim W, Friedlander T, Chou J, Li H, Das R, Li H, Moussavi-Baygi R, Goodarzi H, Gilbert LA, Lara PN, Evans CP, Goldstein TC, Stuart JM, Tomlins SA, Spratt DE, Cheetham RK, Cheng DT, Farh K, Gehring JS, Hakenberg J, Liao A, Febbo PG, Shon J, Sickler B, Batzoglou S, Knudsen KE, He HH, Huang J, Wyatt AW, Dehm SM, Ashworth A, Chinnaiyan AM, Maher CA, Small EJ, Feng FY. Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer. Cell. 2018 07 26; 174(3):758-769.e9. PMID: 30033370.
      View in: PubMed
    7. Wu YM, Cieslik M, Lonigro RJ, Vats P, Reimers MA, Cao X, Ning Y, Wang L, Kunju LP, de Sarkar N, Heath EI, Chou J, Feng FY, Nelson PS, de Bono JS, Zou W, Montgomery B, Alva A, Robinson DR, Chinnaiyan AM. Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer. Cell. 2018 06 14; 173(7):1770-1782.e14. PMID: 29906450.
      View in: PubMed
    8. Kornberg Z, Chou J, Feng FY, Ryan CJ. Prostate cancer in the era of "Omic" medicine: recognizing the importance of DNA damage repair pathways. Ann Transl Med. 2018 May; 6(9):161. PMID: 29911109.
      View in: PubMed
    9. Devignes CS, Aslan Y, Brenot A, Devillers A, Schepers K, Fabre S, Chou J, Casbon AJ, Werb Z, Provot S. HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice. Proc Natl Acad Sci U S A. 2018 01 30; 115(5):E992-E1001. PMID: 29339479.
      View in: PubMed
    10. Shahi P, Wang CY, Chou J, Hagerling C, Gonzalez Velozo H, Ruderisch A, Yu Y, Lai MD, Werb Z. GATA3 targets semaphorin 3B in mammary epithelial cells to suppress breast cancer progression and metastasis. Oncogene. 2017 10 05; 36(40):5567-5575. PMID: 28581515.
      View in: PubMed
    11. Chou J, Wallender E, Schwartz BS. Respiratory Failure in a Woman 8 Months After an Allogeneic Stem Cell Transplant. JAMA Oncol. 2016 Dec 01; 2(12):1651-1652. PMID: 27559706.
      View in: PubMed
    12. Chou J, Beutler LR, Goldschlager N. Electrocardiography Evolution in a Woman Presenting With Alcohol Withdrawal Seizures and Cocaine Use. JAMA Intern Med. 2016 05 01; 176(5):693-5. PMID: 27019877.
      View in: PubMed
    13. Chou J, Chan MF, Werb Z. Metalloproteinases: a Functional Pathway for Myeloid Cells. Microbiol Spectr. 2016 04; 4(2). PMID: 27227311.
      View in: PubMed
    14. Shahi P, Slorach EM, Wang CY, Chou J, Lu A, Ruderisch A, Werb Z. The Transcriptional Repressor ZNF503/Zeppo2 Promotes Mammary Epithelial Cell Proliferation and Enhances Cell Invasion. J Biol Chem. 2015 Feb 06; 290(6):3803-13. PMID: 25538248.
      View in: PubMed
    15. Bonnans C, Chou J, Werb Z. Remodelling the extracellular matrix in development and disease. Nat Rev Mol Cell Biol. 2014 Dec; 15(12):786-801. PMID: 25415508.
      View in: PubMed
    16. Chou J, Shahi P, Werb Z. microRNA-mediated regulation of the tumor microenvironment. Cell Cycle. 2013 Oct 15; 12(20):3262-71. PMID: 24036551.
      View in: PubMed
    17. Chou J, Lin JH, Brenot A, Kim JW, Provot S, Werb Z. GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression. Nat Cell Biol. 2013 Feb; 15(2):201-13. PMID: 23354167.
      View in: PubMed
    18. Chou J, Werb Z. MicroRNAs play a big role in regulating ovarian cancer-associated fibroblasts and the tumor microenvironment. Cancer Discov. 2012 Dec; 2(12):1078-80. PMID: 23230184.
      View in: PubMed
    19. Littlepage LE, Adler AS, Kouros-Mehr H, Huang G, Chou J, Krig SR, Griffith OL, Korkola JE, Qu K, Lawson DA, Xue Q, Sternlicht MD, Dijkgraaf GJ, Yaswen P, Rugo HS, Sweeney CA, Collins CC, Gray JW, Chang HY, Werb Z. The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression. Cancer Discov. 2012 Jul; 2(7):638-51. PMID: 22728437.
      View in: PubMed
    20. Slorach EM, Chou J, Werb Z. Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization. Genes Dev. 2011 Mar 01; 25(5):471-84. PMID: 21317240.
      View in: PubMed
    21. Chou J, Provot S, Werb Z. GATA3 in development and cancer differentiation: cells GATA have it! J Cell Physiol. 2010 Jan; 222(1):42-9. PMID: 19798694.
      View in: PubMed
    22. Allen E, Ding J, Wang W, Pramanik S, Chou J, Yau V, Yang Y. Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival. Nature. 2005 Nov 10; 438(7065):224-8. PMID: 16227972.
      View in: PubMed
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