Xiaolin Zhu, MD, PhD

Title(s)Adjunct Instructor, Medicine
SchoolSchool of Medicine
Address550 16th Street, #6666
San Francisco CA 94158
PronounsHe/Him/His
ORCID ORCID Icon0000-0002-3221-595X Additional info
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    Collapse Biography 
    Collapse Education and Training
    Shanghai Jiao Tong University School of MedicineBachelor of Medicine (MD equivalent)06/2011Clinical Medicine
    Duke UniversityPhD06/2017Genetics and Genomics
    UT Southwestern Medical CenterResidency06/2020Internal Medicine
    UCSFFellowship06/2024Hematology/Oncology
    Collapse Awards and Honors
    Conquer Cancer, the ASCO Foundation2022  - 2023ASCO Young Investigator Award
    Prostate Cancer Foundation2022  - 2025PCF Young Investigator Award
    Department of Defense2024  - 2028Physician Research Award

    Collapse Overview 
    Collapse Mentoring

    Collapse Research 
    Collapse Research Activities and Funding
    Investigating SSTR1 as a novel biomarker and therapeutic target in advanced prostate cancer
    Department of Defense PC230021Jul 1, 2024 - Jul 1, 2028
    Role: Principal Investigator
    Investigating SSTR1 in acquired resistance to androgen receptor signaling inhibitors in advanced prostate cancer
    Prostate Cancer Foundation 22YOUN07Nov 1, 2022 - Nov 1, 2025
    Role: Principal Investigator
    Integrated Genomic Profiling to Define Acquired Resistance Mechanisms to Androgen Receptor Signaling Inhibition in Metastatic Castration-Resistant Prostate Cancer
    Conquer Cancer, the ASCO Foundation 139208AJul 1, 2022 - Jun 30, 2023
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Collaboration Interests

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Androgen Receptor Inhibition Increases MHC Class I Expression and Improves Immune Response in Prostate Cancer. Cancer Discov. 2025 Mar 03; 15(3):481-494. Chesner LN, Polesso F, Graff JN, Hawley JE, Smith AK, Lundberg A, Das R, Shenoy T, Sjöström M, Zhao F, Hu YM, Linder S, Chen WS, Hawkins RM, Shrestha R, Zhu X, Foye A, Li H, Kim LM, Bhalla M, O'loughlin T, Kuzuoglu-Ozturk D, Hua JT, Badura ML, Wilkinson S, Trostel SY, Bergman AM, Ruggero D, Drake CG, Sowalsky AG, Fong L, Cooperberg MR, Zwart W, Guan X, Ashworth A, Xia Z, Quigley DA, Gilbert LA, Feng FY, Moran AE. PMID: 39652470; PMCID: PMC11873725.
      View in: PubMed   Mentions:    Fields:    
    2. Emerging Therapeutic Targets of Neuroendocrine Prostate Cancer. Curr Oncol Rep. 2025 Feb 27. Zhu X, Ding CC, Aggarwal RR. PMID: 40011325.
      View in: PubMed   Mentions:
    3. An Atlas of Accessible Chromatin in Advanced Prostate Cancer Reveals the Epigenetic Evolution during Tumor Progression. Cancer Res. 2024 Sep 16; 84(18):3086-3100. Shrestha R, Chesner LN, Zhang M, Zhou S, Foye A, Lundberg A, Weinstein AS, Sjöström M, Zhu X, Moreno-Rodriguez T, Li H, SU2C/PCF West Coast Prostate Cancer Dream Team, Alumkal JJ, Aggarwal R, Small EJ, Lupien M, Quigley DA, Feng FY. PMID: 38990734.
      View in: PubMed   Mentions: 3     Fields:    
    4. Genomic and transcriptomic features of androgen receptor signaling inhibitor resistance in metastatic castration-resistant prostate cancer. J Clin Invest. 2024 Aug 13; 134(19). Zhu X, Farsh T, Vis D, Yu I, Li H, Liu T, Sjöström M, Shrestha R, Kneppers J, Severson T, Zhang M, Lundberg A, Moreno Rodriguez T, Weinstein AS, Foye A, Mehra N, Aggarwal RR, Bergman AM, Small EJ, Lack NA, Zwart W, Quigley DA, van der Heijden MS, Feng FY. PMID: 39352383; PMCID: PMC11444163.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. HER2 overexpression in urothelial carcinoma with GATA3 and PPARG copy number gains. Oncologist. 2024 Aug 05; 29(8):e1094-e1097. Zhu X, Chan E, Turski ML, Mendez CE, Hsu SC, Kumar V, Shipp C, Jindal T, Chang K, Onodera C, Devine WP, Grenert JP, Stohr BA, Ding CC, Stachler MD, Quigley DA, Feng FY, Chu CE, Porten SP, Chou J, Friedlander TW, Koshkin VS. PMID: 38908022; PMCID: PMC11299940.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Enfortumab vedotin and pembrolizumab as new first-line standard for metastatic urothelial cancer. Med. 2024 Feb 09; 5(2):106-108. Zhu X, Koshkin VS. PMID: 38128535.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer. Cancer Res. 2023 08 15; 83(16):2763-2774. Lundberg A, Zhang M, Aggarwal R, Li H, Zhang L, Foye A, Sjöström M, Chou J, Chang K, Moreno-Rodriguez T, Shrestha R, Baskin A, Zhu X, Weinstein AS, Younger N, Alumkal JJ, Beer TM, Chi KN, Evans CP, Gleave M, Lara PN, Reiter RE, Rettig MB, Witte ON, Wyatt AW, Feng FY, Small EJ, Quigley DA. PMID: 37289025; PMCID: PMC10425725.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    8. Impact of Squamous Histology on Clinical Outcomes and Molecular Profiling in Metastatic Urothelial Carcinoma Patients Treated With Immune Checkpoint Inhibitors or Enfortumab Vedotin. Clin Genitourin Cancer. 2023 10; 21(5):e394-e404. Jindal T, Zhang L, Deshmukh P, Reyes K, Chan E, Kumar V, Zhu X, Maldonado E, Feng S, Johnson M, Angelidakis A, Kwon D, Desai A, Borno HT, Bose R, Wong A, Hong J, Carroll P, Meng M, Porten S, Aggarwal R, Small EJ, Fong L, Chou J, Friedlander T, de Kouchkovsky I, Koshkin VS. PMID: 37316414.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. Somatic alterations of TP53 and MDM2 associated with response to enfortumab vedotin in patients with advanced urothelial cancer. Front Oncol. 2023; 13:1161089. Jindal T, Zhu X, Bose R, Kumar V, Maldonado E, Deshmukh P, Shipp C, Feng S, Johnson MS, Angelidakis A, Kwon D, Borno HT, de Kouchkovsky I, Desai A, Aggarwal R, Fong L, Small EJ, Wong A, Porten S, Chou J, Friedlander T, Koshkin VS. PMID: 37091148; PMCID: PMC10113661.
      View in: PubMed   Mentions: 6  
    10. New insights into tardive dyskinesia genetics: Implementation of whole-exome sequencing approach. Prog Neuropsychopharmacol Biol Psychiatry. 2019 08 30; 94:109659. Alkelai A, Greenbaum L, Heinzen EL, Baugh EH, Teitelbaum A, Zhu X, Strous RD, Tatarskyy P, Zai CC, Tiwari AK, Tampakeras M, Freeman N, Müller DJ, Voineskos AN, Lieberman JA, Delaney SL, Meltzer HY, Remington G, Kennedy JL, Pulver AE, Peabody EP, Levy DL, Lerer B. PMID: 31153890.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    11. Whole-exome sequencing in the evaluation of fetal structural anomalies: a prospective cohort study. Lancet. 2019 02 23; 393(10173):758-767. Petrovski S, Aggarwal V, Giordano JL, Stosic M, Wou K, Bier L, Spiegel E, Brennan K, Stong N, Jobanputra V, Ren Z, Zhu X, Mebane C, Nahum O, Wang Q, Kamalakaran S, Malone C, Anyane-Yeboa K, Miller R, Levy B, Goldstein DB, Wapner RJ. PMID: 30712878.
      View in: PubMed   Mentions: 194     Fields:    Translation:Humans
    12. De-novo mutations in patients with chronic ultra-refractory epilepsy with onset after age five years. Eur J Med Genet. 2020 Jan; 63(1):103625. McCormack M, McGinty RN, Zhu X, Slattery L, Heinzen EL, EPIGEN Consortium, Costello DJ, Delanty N, Cavalleri GL. PMID: 30711678.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    13. Mutation Clearance after Transplantation for Myelodysplastic Syndrome. N Engl J Med. 2018 12 13; 379(24):2379-2380. Zhu X. PMID: 30592586.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. De novo and inherited private variants in MAP1B in periventricular nodular heterotopia. PLoS Genet. 2018 05; 14(5):e1007281. Heinzen EL, O'Neill AC, Zhu X, Allen AS, Bahlo M, Chelly J, Chen MH, Dobyns WB, Freytag S, Guerrini R, Leventer RJ, Poduri A, Robertson SP, Walsh CA, Zhang M, Epi4K Consortium, Epilepsy Phenome/Genome Project. PMID: 29738522; PMCID: PMC5965900.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    15. A case-control collapsing analysis identifies epilepsy genes implicated in trio sequencing studies focused on de novo mutations. PLoS Genet. 2017 Nov; 13(11):e1007104. Zhu X, Padmanabhan R, Copeland B, Bridgers J, Ren Z, Kamalakaran S, O'Driscoll-Collins A, Berkovic SF, Scheffer IE, Poduri A, Mei D, Guerrini R, Lowenstein DH, Allen AS, Heinzen EL, Goldstein DB. PMID: 29186148; PMCID: PMC5724893.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    16. Sensitivity of whole exome sequencing in detecting infantile- and late-onset Pompe disease. Mol Genet Metab. 2017 12; 122(4):189-197. Mori M, Haskell G, Kazi Z, Zhu X, DeArmey SM, Goldstein JL, Bali D, Rehder C, Cirulli ET, Kishnani PS. PMID: 29122469; PMCID: PMC5907499.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    17. Germline De Novo Mutations in GNB1 Cause Severe Neurodevelopmental Disability, Hypotonia, and Seizures. Am J Hum Genet. 2016 05 05; 98(5):1001-1010. Petrovski S, Küry S, Myers CT, Anyane-Yeboa K, Cogné B, Bialer M, Xia F, Hemati P, Riviello J, Mehaffey M, Besnard T, Becraft E, Wadley A, Politi AR, Colombo S, Zhu X, Ren Z, Andrews I, Dudding-Byth T, Schneider AL, Wallace G, University of Washington Center for Mendelian Genomics, Rosen ABI, Schelley S, Enns GM, Corre P, Dalton J, Mercier S, Latypova X, Schmitt S, Guzman E, Moore C, Bier L, Heinzen EL, Karachunski P, Shur N, Grebe T, Basinger A, Nguyen JM, Bézieau S, Wierenga K, Bernstein JA, Scheffer IE, Rosenfeld JA, Mefford HC, Isidor B, Goldstein DB. PMID: 27108799; PMCID: PMC4863562.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    18. Joint detection of copy number variations in parent-offspring trios. Bioinformatics. 2016 04 15; 32(8):1130-7. Liu Y, Liu J, Lu J, Peng J, Juan L, Zhu X, Li B, Wang Y. PMID: 26644415; PMCID: PMC4907378.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    19. Whole-exome sequencing in undiagnosed genetic diseases: interpreting 119 trios. Genet Med. 2015 Oct; 17(10):774-81. Zhu X, Petrovski S, Xie P, Ruzzo EK, Lu YF, McSweeney KM, Ben-Zeev B, Nissenkorn A, Anikster Y, Oz-Levi D, Dhindsa RS, Hitomi Y, Schoch K, Spillmann RC, Heimer G, Marek-Yagel D, Tzadok M, Han Y, Worley G, Goldstein J, Jiang YH, Lancet D, Pras E, Shashi V, McHale D, Need AC, Goldstein DB. PMID: 25590979; PMCID: PMC4791490.
      View in: PubMed   Mentions: 180     Fields:    Translation:Humans
    20. One gene, many neuropsychiatric disorders: lessons from Mendelian diseases. Nat Neurosci. 2014 Jun; 17(6):773-81. Zhu X, Need AC, Petrovski S, Goldstein DB. PMID: 24866043.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimals
    21. An evaluation of copy number variation detection tools from whole-exome sequencing data. Hum Mutat. 2014 Jul; 35(7):899-907. Tan R, Wang Y, Kleinstein SE, Liu Y, Zhu X, Guo H, Jiang Q, Allen AS, Zhu M. PMID: 24599517.
      View in: PubMed   Mentions: 110     Fields:    Translation:Humans
    22. A gradient-boosting approach for filtering de novo mutations in parent-offspring trios. Bioinformatics. 2014 Jul 01; 30(13):1830-6. Liu Y, Li B, Tan R, Zhu X, Wang Y. PMID: 24618463; PMCID: PMC4071207.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
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