Matthieu Legrand, MD, PhD
|Paris Diderot University, Paris||Full Professor||2017||Anesthesiology and Critical Care Medicine|
|Paris Diderot University, Paris, France||Research director ||2016|
|Paris Diderot University, Paris, France||Associated Professor||2013||Anesthesiology and Critical Care Medicine|
|Paris Diderot University, Paris, France||PhD||2012||Renal physiology|
|Paris Diderot University, Paris, France||Assistant Professor||2010||Anesthesiology and Critical Care Medicine|
|Pierre and Marie Curie University , Paris, France||Residency||2010||Anesthesiology and Critical Care Medicine|
|Paris Diderot University, Paris, France||MSc||2007||Cardiovascular physiology|
|Toulouse Rangueil Univeristy, Toulouse, France||MD||2003|
Dr. Legrand completed his postgraduate training in Anesthesiology and Critical Care from 2003 to 2010 at Pierre and Marie Curie University in Paris, France, receiving his medical degree in 2010. Thereafter, he received a Ph.D. degree in Cardiovascular Physiology from Sorbonne Paris Cite University in 2012.
Upon obtaining his medical degree, he was appointed as an Assistant Professor at the Paris Diderot University and was promoted associated to Full Professor of Anesthesiology and Critical Care Medicine in 2017. He also served as the Medical Director of Burn and surgical Intensive Care Units at Saint-Louis Hospital.
As a clinical-scientist practicing critical care medicine and anesthesiology, I care for severely ill patients, including patients with sepsis, after major surgery or any life-threatening condition with the ultimate goal of improving global outcomes and limiting the long-term consequences of acute critical illnesses. My professional interests include diagnosing and optimum treatments of cardiovascular failure, the diagnosis, pathophysiology, and treatment of acute kidney injury and metabolic disorders, applied physiology, and bedside medical education. My research interests have been focusing on the development and validation of several biomarkers, mostly in the setting of sepsis and diagnostic biomarkers of Acute Kidney Injury, intending to improve the non-optimal performance of current diagnostic methods. We have investigated factors associated with poor outcomes in severely ill burn patients, with a particular interest in hemodynamic factors, the occurrence of Acute Kidney Injury, and sepsis. I have also investigated the pathophysiology of Acute Kidney Injury and the microcirculation role in kidney damage. We are investigating the use of vaso-active agents - from vasopressors to vaso dilators - to improve outcomes in surgical and critically ill patients. We are also how modulating the renin-angiotensin system impacts outcomes after major surgery or after Acute Kidney Injury .