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Matthieu Legrand, MD, PhD

Title(s)Professor, Anesthesia
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    Paris Diderot University, ParisFull Professor2017Anesthesiology and Critical Care Medicine
    Paris Diderot University, Paris, FranceResearch director 2016
    Paris Diderot University, Paris, FranceAssociated Professor2013Anesthesiology and Critical Care Medicine
    Paris Diderot University, Paris, FrancePhD2012Renal physiology
    Paris Diderot University, Paris, FranceAssistant Professor2010Anesthesiology and Critical Care Medicine
    Pierre and Marie Curie University , Paris, FranceResidency2010Anesthesiology and Critical Care Medicine
    Paris Diderot University, Paris, FranceMSc2007Cardiovascular physiology
    Toulouse Rangueil Univeristy, Toulouse, FranceMD2003

    Collapse Overview 
    Collapse Overview
    Dr. Legrand completed his postgraduate training in Anesthesiology and Critical Care from 2003 to 2010 at Pierre and Marie Curie University in Paris, France, receiving his medical degree in 2010. Thereafter, he received a PhD degree in Cardiovascular Physiology from Sorbonne Paris Cite University in 2012.

    Upon obtaining his medical degree, Dr. Legrand was appointed as an Assistant Professor at the Paris Diderot University and was promoted associated to Full Professor of Anesthesiology and Critical Care Medicine in 2017. He had also been serving as the Medical Director of Burn and surgical Intensive Care Units at Saint-Louis Hospital.

    His research interests cover the pathophysiology of acute kidney injury in peri-operative and critically ill patients and the mechanisms of cardiovascular consequences of acute kidney injury. He has worked on developing and validating several biomarkers in the setting of kidney injury, sepsis and amniotic fluid embolism. He is the coordinator of several large multicenter studies.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ishino S, Hattori S, Savarino J, Legrand M, Albalat E, Albarede F, Preunkert S, Jourdain B, Yoshida N. Homogeneous sulfur isotope signature in East Antarctica and implication for sulfur source shifts through the last glacial-interglacial cycle. Sci Rep. 2019 Aug 27; 9(1):12378. PMID: 31455786.
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    2. Raux M, Carli P, Lapostolle F, Langlois M, Yordanov Y, Féral-Pierssens AL, Woloch A, Ogereau C, Gayat E, Attias A, Pateron D, Castier Y, François A, Ludes B, Dolla E, Tourtier JP, Riou B. Analysis of the medical response to November 2015 Paris terrorist attacks: resource utilization according to the cause of injury. Intensive Care Med. 2019 Sep; 45(9):1231-1240. PMID: 31418059.
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    3. Legrand M, Sonneville R. Understanding the renal response to brain injury. Intensive Care Med. 2019 Aug; 45(8):1112-1115. PMID: 31312853.
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    4. Lemoine L, Chouihed T, Legrand M, Rossignol P, Potel G, Montassier E. Hyperkalemia in the Emergency Department: Urgent Need for a Rigorous Evaluation of the First-Line Treatments. J Emerg Med. 2019 Jul; 57(1):102-103. PMID: 31326002.
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    5. Pastene B, Cinotti R, Gayat E, Duranteau J, Lu Q, Montravers P, Pili-Floury S, Rennuit I, Mebazaa A, Leone M. Long-term mortality and quality of life after trauma: an ancillary study from the prospective multicenter trial FROG-ICU. Eur J Trauma Emerg Surg. 2019 Jun 18. PMID: 31214722.
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    6. Coutrot M, Dépret F, Legrand M. Is Nitric Oxide Nephro- or Cardioprotective? Am J Respir Crit Care Med. 2019 Jun 01; 199(11):1441-1442. PMID: 30840832.
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    7. de Tymowski C, Dépret F, Soussi S, Nabila M, Vauchel T, Chaussard M, Benyamina M, Ferry A, Cupaciu A, Jully M, Oueslati H, Fratani A, Coutrot M, Sogni P, Mimoun M, Chaouat M, Zagdanski AM, De Kerviler E, Mebazaa A, Moreau R, Mallet V, Legrand M. Contributing factors and outcomes of burn-associated cholestasis. J Hepatol. 2019 May 30. PMID: 31152758.
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    8. Legrand M, Kellum JA. Acute Kidney Injury Related to Sepsis-Reply. JAMA. 2019 05 14; 321(18):1828-1829. PMID: 31087019.
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    9. Pilmis B, Petitjean G, Lesprit P, Lafaurie M, El Helali N, Le Monnier A. Continuous infusion of ceftolozane/tazobactam is associated with a higher probability of target attainment in patients infected with Pseudomonas aeruginosa. Eur J Clin Microbiol Infect Dis. 2019 Aug; 38(8):1457-1461. PMID: 31073653.
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    10. Atramont A, Lindecker-Cournil V, Rudant J, Tajahmady A, Drewniak N, Fouard A, Singer M, Leone M, Legrand M. Association of Age With Short-term and Long-term Mortality Among Patients Discharged From Intensive Care Units in France. JAMA Netw Open. 2019 May 03; 2(5):e193215. PMID: 31074809.
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    11. Dudoignon E, Dépret F, Legrand M. Is the Renin-Angiotensin-Aldosterone System Good for the Kidney in Acute Settings? Nephron. 2019 Apr 18; 1-5. PMID: 30999307.
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    12. Legrand M, Futier E, Leone M, Deniau B, Mebazaa A, Plaud B, Coriat P, Rossignol P, Vicaut E, Gayat E. Impact of renin-angiotensin system inhibitors continuation versus discontinuation on outcome after major surgery: protocol of a multicenter randomized, controlled trial (STOP-or-NOT trial). Trials. 2019 Mar 05; 20(1):160. PMID: 30836981.
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    13. Dépret F, Peacock WF, Liu KD, Rafique Z, Rossignol P, Legrand M. Management of hyperkalemia in the acutely ill patient. Ann Intensive Care. 2019 Feb 28; 9(1):32. PMID: 30820692.
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    14. Garnier M, Gallah S, Vimont S, Benzerara Y, Labbe V, Constant AL, Siami S, Guerot E, Compain F, Mainardi JL, Montil M, Quesnel C. Multicentre randomised controlled trial to investigate usefulness of the rapid diagnostic ßLACTA test performed directly on bacterial cell pellets from respiratory, urinary or blood samples for the early de-escalation of carbapenems in septic intensive care unit patients: the BLUE-CarbA protocol. BMJ Open. 2019 Feb 19; 9(2):e024561. PMID: 30782909.
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    15. Soussi S, Taccori M, De Tymowski C, Depret F, Chaussard M, Fratani A, Jully M, Cupaciu A, Ferry A, Benyamina M, Serror K, Boccara D, Chaouat M, Mimoun M, Cattan P, Zagdanski AM, Anstey J, Mebazaa A, Legrand M. Risk Factors for Acute Mesenteric Ischemia in Critically Ill Burns Patients-A Matched Case-Control Study. Shock. 2019 Feb; 51(2):153-160. PMID: 29561390.
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    16. Tabone O, Mommert M, Jourdan C, Cerrato E, Legrand M, Lepape A, Allaouchiche B, Rimmelé T, Pachot A, Monneret G, Venet F, Mallet F, Textoris J. Endogenous Retroviruses Transcriptional Modulation After Severe Infection, Trauma and Burn. Front Immunol. 2018; 9:3091. PMID: 30671061.
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    17. Mebazaa A, Geven C, Hollinger A, Wittebole X, Chousterman BG, Blet A, Gayat E, Hartmann O, Scigalla P, Struck J, Bergmann A, Antonelli M, Beishuizen A, Constantin JM, Damoisel C, Deye N, Di Somma S, Dugernier T, François B, Gaudry S, Huberlant V, Lascarrou JB, Marx G, Mercier E, Oueslati H, Pickkers P, Sonneville R, Legrand M, Laterre PF. Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study. Crit Care. 2018 12 21; 22(1):354. PMID: 30583748.
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    18. Dudoignon E, Alanio A, Anstey J, Depret F, Coutrot M, Fratani A, Jully M, Cupaciu A, Chaussard M, Oueslati H, Ferry A, Benyamina M, de Tymowski C, Boccara D, Serror K, Chaouat M, Mimoun M, Lafaurie M, Denis B, Gits-Muselli M, Bretagne S, Mebazaa A, Legrand M, Soussi S. Outcome and potentially modifiable risk factors for candidemia in critically ill burns patients: A matched cohort study. Mycoses. 2019 Mar; 62(3):237-246. PMID: 30478963.
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    19. Legrand M, Kellum JA. Serum Creatinine in the Critically Ill Patient With Sepsis. JAMA. 2018 Dec 11; 320(22):2369-2370. PMID: 30453322.
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    20. Munier AL, Biard L, Legrand M, Rousseau C, Lafaurie M, Donay JL, Flicoteaux R, Mebazaa A, Mimoun M, Molina JM. Incidence, risk factors and outcome of multi-drug resistant Acinetobacter baumannii nosocomial infections during an outbreak in a burn unit. Int J Infect Dis. 2019 Feb; 79:179-184. PMID: 30529108.
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    21. Vauchel T, Pirracchio R, Chaussard M, Lafaurie M, Rouveau M, Rousseau C, Benyamina M, Soussi S, Dépret F, Ferry A, Oueslati H, Chaouat M, Mimoun M, Jarlier V, Moreno N, Mebazaa A, Legrand M. Impact of an Acinetobacter baumannii outbreak on kidney events in a burn unit: A targeted machine learning analysis. Am J Infect Control. 2019 Apr; 47(4):435-438. PMID: 30503627.
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    22. Legrand M. Hydroxocobalamin as a Cause of Oxalate Nephropathy. Kidney Int Rep. 2019 Jan; 4(1):185. PMID: 30596186.
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    23. Leone M, Constantin JM, Dahyot-Fizelier C, Duracher-Gout C, Joannes-Boyau O, Langeron O, Legrand M, Mahjoub Y, Mirek S, Mrozek S, Muller L, Orban JC, Quesnel C, Roquilly A, Virat A, Capdevila X. French intensive care unit organisation. Anaesth Crit Care Pain Med. 2018 12; 37(6):625-627. PMID: 30580776.
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    24. Schetz M, Legrand M. CRRT and ECMO: Dialysis catheter or connection to the ECMO circuit? Anaesth Crit Care Pain Med. 2018 12; 37(6):519-520. PMID: 30347250.
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    25. Montassier E, Legrand M, Rossignol P, Potel G. Hyperkalemia in the emergency department: Consider the use of nebulized salbutamol. Am J Emerg Med. 2019 May; 37(5):1004. PMID: 30348470.
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    26. Dépret F, Boutin L, Jarkovský J, Chaussard M, Soussi S, Bataille A, Oueslati H, Moreno N, de Tymowski C, Parenica J, Benešová K, Vauchel T, Ferry A, Benyamina M, Cupaciu A, Coutrot M, Garnier JP, Serror K, Chaouat M, Mebazaa A, Legrand M. Prediction of major adverse kidney events in critically ill burn patients. Burns. 2018 12; 44(8):1887-1894. PMID: 30322739.
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    27. Darmon M, Bourmaud A, Reynaud M, Rouleau S, Meziani F, Boivin A, Benyamina M, Vincent F, Lautrette A, Leroy C, Cohen Y, Legrand M, Morel J, Terreaux J, Schnell D. Performance of Doppler-based resistive index and semi-quantitative renal perfusion in predicting persistent AKI: results of a prospective multicenter study. Intensive Care Med. 2018 Nov; 44(11):1904-1913. PMID: 30291377.
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    28. Grangé C, Dépret F, Oueslati H, Legrand M, Soussi S. Planned enteral nutrition over-prescription to cover caloric and protein requirements in severely-ill burn patients. Burns. 2018 12; 44(8):2106-2107. PMID: 30274813.
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    29. Legrand M. Negative trials in critical care medicine and the hurdles. Lancet Respir Med. 2018 10; 6(10):e53. PMID: 30303091.
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    30. Arrigo M, Ishihara S, Feliot E, Rudiger A, Deye N, Cariou A, Guidet B, Jaber S, Leone M, Resche-Rigon M, Vieillard Baron A, Legrand M, Gayat E, Mebazaa A. New-onset atrial fibrillation in critically ill patients and its association with mortality: A report from the FROG-ICU study. Int J Cardiol. 2018 Sep 01; 266:95-99. PMID: 29887481.
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    31. Soussi S, Dépret F, Benyamina M, Legrand M. Early Hemodynamic Management of Critically Ill Burn Patients. Anesthesiology. 2018 Sep; 129(3):583-589. PMID: 29958240.
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    32. Codorniu A, Lemasle L, Legrand M, Blet A, Mebazaa A, Gayat E. Methods used to assess the performance of biomarkers for the diagnosis of acute kidney injury: a systematic review and meta-analysis. Biomarkers. 2018 Dec; 23(8):766-772. PMID: 29943660.
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    33. Hollinger A, Wittebole X, François B, Pickkers P, Antonelli M, Gayat E, Chousterman BG, Lascarrou JB, Dugernier T, Di Somma S, Struck J, Bergmann A, Beishuizen A, Constantin JM, Damoisel C, Deye N, Gaudry S, Huberlant V, Marx G, Mercier E, Oueslati H, Hartmann O, Sonneville R, Laterre PF, Mebazaa A, Legrand M. Proenkephalin A 119-159 (Penkid) Is an Early Biomarker of Septic Acute Kidney Injury: The Kidney in Sepsis and Septic Shock (Kid-SSS) Study. Kidney Int Rep. 2018 11; 3(6):1424-1433. PMID: 30450469.
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    34. Soussi S, Berger MM, Colpaert K, Dünser MW, Guttormsen AB, Juffermans NP, Knape P, Koksal G, Lavrentieva A, Leclerc T, Lorente JA, Martin-Loeches I, Metnitz P, Pantet O, Pelosi P, Rousseau AF, Sjöberg F, Legrand M. Hemodynamic management of critically ill burn patients: an international survey. Crit Care. 2018 08 17; 22(1):194. PMID: 30115108.
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    35. Lefrant JY, Lorne E, Asehnoune K, Ausset S, Beaulieu P, Biais M, Brichant JF, Charbit B, Constantin JM, Cuvillon P, Dadure C, Dahmani S, David JS, Fuchs-Buder T, Geeraerts T, Godier A, Hanouz JL, Joannes-Boyau O, Kipnis E, Laudenbach V, Le Guen M, Legrand M, Lescot T, Marret E, Mongardon N, Ouattara A, Pierre S, Roberts J, Schneider A, Tourtier JP, Tran L, Pirracchio R, Capdevila X. Determining the editorial policy of Anaesthesia Critical Care and Pain Medicine (ACCPM). Anaesth Crit Care Pain Med. 2018 08; 37(4):299-301. PMID: 30055826.
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    36. Boccara D, Bekara F, Soussi S, Legrand M, Chaouat M, Mimoun M, Serror K. Ongoing Development and Evaluation of a Method of Telemedicine: Burn Care Management With a Smartphone. J Burn Care Res. 2018 Jun 13; 39(4):580-584. PMID: 29789857.
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    37. Legrand M, Bastien O, Chaouat M, Mebazaa A, Séval F, Mimoun M, Vallet B. When ethics collides with a legal gap in emergency life-threatening conditions. Br J Anaesth. 2018 Aug; 121(2):513-514. PMID: 30032901.
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    38. Gayat E, Hollinger A, Cariou A, Deye N, Vieillard-Baron A, Jaber S, Chousterman BG, Lu Q, Laterre PF, Monnet X, Darmon M, Leone M, Guidet B, Sonneville R, Lefrant JY, Fournier MC, Resche-Rigon M, Mebazaa A, Legrand M. Impact of angiotensin-converting enzyme inhibitors or receptor blockers on post-ICU discharge outcome in patients with acute kidney injury. Intensive Care Med. 2018 May; 44(5):598-605. PMID: 29766216.
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    39. Legrand M, Ait-Oufella H, Ince C. Could resuscitation be based on microcirculation data? Yes. Intensive Care Med. 2018 Jun; 44(6):944-946. PMID: 29736786.
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    40. Garcia-Hermoso D, Criscuolo A, Lee SC, Legrand M, Chaouat M, Denis B, Lafaurie M, Rouveau M, Soler C, Schaal JV, Mimoun M, Mebazaa A, Heitman J, Dromer F, Brisse S, Bretagne S, Alanio A. Outbreak of Invasive Wound Mucormycosis in a Burn Unit Due to Multiple Strains of Mucor circinelloides f. circinelloides Resolved by Whole-Genome Sequencing. MBio. 2018 04 24; 9(2). PMID: 29691339.
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    41. Legrand M, Soussi S, Depret F. Cardiac output and CVP monitoring… to guide fluid removal. Crit Care. 2018 04 12; 22(1):89. PMID: 29642924.
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    42. Perbet S, Bourdeaux D, Lenoire A, Biboulet C, Pereira B, Sadoune M, Plaud B, Launay JM, Bazin JE, Sautou V, Mebazaa A, Houze P, Constantin JM, Legrand M. Sevoflurane for procedural sedation in critically ill patients: A pharmacokinetic comparative study between burn and non-burn patients. Anaesth Crit Care Pain Med. 2018 12; 37(6):551-556. PMID: 29455032.
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    43. De Tymowski C, Legrand M. Tolvaptan in Later-Stage Polycystic Kidney Disease. N Engl J Med. 2018 02 01; 378(5):488. PMID: 29394474.
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    44. Bonnassieux M, Duclos A, Schneider AG, Schmidt A, Bénard S, Cancalon C, Joannes-Boyau O, Ichai C, Constantin JM, Lefrant JY, Kellum JA, Rimmelé T. Renal Replacement Therapy Modality in the ICU and Renal Recovery at Hospital Discharge. Crit Care Med. 2018 02; 46(2):e102-e110. PMID: 29088005.
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    45. Gayat E, Touchard C, Hollinger A, Vieillard-Baron A, Mebazaa A, Legrand M. Back-to-back comparison of penKID with NephroCheck® to predict acute kidney injury at admission in intensive care unit: a brief report. Crit Care. 2018 01 29; 22(1):24. PMID: 29378645.
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    46. Gayat E, Cariou A, Deye N, Vieillard-Baron A, Jaber S, Damoisel C, Lu Q, Monnet X, Rennuit I, Azoulay E, Léone M, Oueslati H, Guidet B, Friedman D, Tesnière A, Sonneville R, Montravers P, Pili-Floury S, Lefrant JY, Duranteau J, Laterre PF, Brechot N, Chevreul K, Michel M, Cholley B, Legrand M, Launay JM, Vicaut E, Singer M, Resche-Rigon M, Mebazaa A. Determinants of long-term outcome in ICU survivors: results from the FROG-ICU study. Crit Care. 2018 01 18; 22(1):8. PMID: 29347987.
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    47. Soussi S, Vallée F, Roquet F, Bevilacqua V, Benyamina M, Ferry A, Cupaciu A, Chaussard M, De Tymowski C, Boccara D, Mimoun M, Chaouat M, Anstey J, Mebazaa A, Legrand M. Measurement of Oxygen Consumption Variations in Critically Ill Burns Patients: Are the Fick Method and Indirect Calorimetry Interchangeable? Shock. 2017 11; 48(5):532-538. PMID: 28452908.
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    48. Legrand M, Ludes PO, Massy Z, Rossignol P, Parenica J, Park JJ, Ishihara S, AlHabib KF, Maggioni A, Miró Ò, Sato N, Cohen-Solal A, Fairman E, Lassus J, Harjola VP, Mueller C, Peacock FW, Choi DJ, Plaisance P, Spinar J, Kosiborod M, Mebazaa A, Gayat E. Association between hypo- and hyperkalemia and outcome in acute heart failure patients: the role of medications. Clin Res Cardiol. 2018 Mar; 107(3):214-221. PMID: 29080909.
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    49. Serror K, Chaouat M, Legrand MM, Depret F, Haddad J, Malca N, Mimoun M, Boccara D. Burns caused by electronic vaping devices (e-cigarettes): A new classification proposal based on mechanisms. Burns. 2018 May; 44(3):544-548. PMID: 29056367.
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    50. Boccara D, Lavocat R, Soussi S, Legrand M, Chaouat M, Mebazaa A, Mimoun M, Blet A, Serror K. Pressure guided surgery of compartment syndrome of the limbs in burn patients. Ann Burns Fire Disasters. 2017 Sep 30; 30(3):193-197. PMID: 29849522.
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    51. Dépret F, Dunyach C, De Tymowski C, Chaussard M, Bataille A, Ferry A, Moreno N, Cupaciu A, Soussi S, Benyamina M, Mebazaa A, Serror K, Chaouat M, Garnier JP, Pirracchio R, Legrand M. Undetectable haptoglobin is associated with major adverse kidney events in critically ill burn patients. Crit Care. 2017 Sep 26; 21(1):245. PMID: 28946897.
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    52. Dépret F, Sitbon A, Soussi S, De Tymowski C, Blet A, Fratani A, Legrand M. Intravenous iloprost to recruit the microcirculation in septic shock patients? Intensive Care Med. 2018 01; 44(1):121-122. PMID: 28921126.
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    53. Legrand M, Mallet V. Intravenous hydroxocobalamin and crystal nephropathy. Nat Rev Nephrol. 2017 09; 13(9):593. PMID: 28757637.
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    54. Munier AL, Biard L, Rousseau C, Legrand M, Lafaurie M, Lomont A, Donay JL, de Beaugrenier E, Flicoteaux R, Mebazaa A, Mimoun M, Molina JM. Incidence, risk factors, and outcome of multidrug-resistant Acinetobacter baumannii acquisition during an outbreak in a burns unit. J Hosp Infect. 2017 Nov; 97(3):226-233. PMID: 28751010.
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    55. De Tymowski C, Soussi S, Depret F, Legrand M. On-line plasma lactate concentration monitoring in critically ill patients. Crit Care. 2017 06 16; 21(1):151. PMID: 28623939.
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    56. Dépret F, Prud'homme M, Legrand M. A Role of Remote Organs Effect in Acute Kidney Injury Outcome. Nephron. 2017; 137(4):273-276. PMID: 28586768.
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    57. Dépret F, Legrand M. Are capillary and arterial lactates interchangeable? Anaesth Crit Care Pain Med. 2017 06; 36(3):149. PMID: 28647080.
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    58. Harjola VP, Mullens W, Banaszewski M, Bauersachs J, Brunner-La Rocca HP, Chioncel O, Collins SP, Doehner W, Filippatos GS, Flammer AJ, Fuhrmann V, Lainscak M, Lassus J, Legrand M, Masip J, Mueller C, Papp Z, Parissis J, Platz E, Rudiger A, Ruschitzka F, Schäfer A, Seferovic PM, Skouri H, Yilmaz MB, Mebazaa A. Organ dysfunction, injury and failure in acute heart failure: from pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur J Heart Fail. 2017 07; 19(7):821-836. PMID: 28560717.
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    59. Mebazaa A, Seronde MF, Gayat E, Tibazarwa K, Anumba DOC, Akrout N, Sadoune M, Sarb J, Arrigo M, Motiejunaite J, Laribi S, Legrand M, Deschamps L, Fazal L, Bouadma L, Collet C, Manivet P, Solal AC, Launay JM, Samuel JL, Sliwa K. Imbalanced Angiogenesis in Peripartum Cardiomyopathy - Diagnostic Value of Placenta Growth Factor. Circ J. 2017 Oct 25; 81(11):1654-1661. PMID: 28552862.
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    60. Schetz M, Legrand M. A nephrologist should be consulted in all cases of acute kidney injury in the ICU: We are not sure. Intensive Care Med. 2017 06; 43(6):880-882. PMID: 28534108.
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    61. Bellomo R, Ronco C, Mehta RL, Asfar P, Boisramé-Helms J, Darmon M, Diehl JL, Duranteau J, Hoste EAJ, Olivier JB, Legrand M, Lerolle N, Malbrain MLNG, Mårtensson J, Oudemans-van Straaten HM, Parienti JJ, Payen D, Perinel S, Peters E, Pickkers P, Rondeau E, Schetz M, Vinsonneau C, Wendon J, Zhang L, Laterre PF. Acute kidney injury in the ICU: from injury to recovery: reports from the 5th Paris International Conference. Ann Intensive Care. 2017 Dec; 7(1):49. PMID: 28474317.
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    62. Darmon M, Ostermann M, Cerda J, Dimopoulos MA, Forni L, Hoste E, Legrand M, Lerolle N, Rondeau E, Schneider A, Souweine B, Schetz M. Diagnostic work-up and specific causes of acute kidney injury. Intensive Care Med. 2017 Jun; 43(6):829-840. PMID: 28444409.
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    63. Parenica J, Jarkovsky J, Malaska J, Mebazaa A, Gottwaldova J, Helanova K, Litzman J, Dastych M, Tomandl J, Spinar J, Dostalova L, Lokaj P, Tomandlova M, Pavkova MG, Sevcik P, Legrand M. Infectious Complications and Immune/Inflammatory Response in Cardiogenic Shock Patients: A Prospective Observational Study. Shock. 2017 02; 47(2):165-174. PMID: 27749762.
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    64. Legrand M, Michel T. Empiric use of hydroxocobalamin in patients with smoke inhlation injury: Not so fast! Burns. 2017 06; 43(4):886. PMID: 28057381.
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    65. Soussi S, Legrand M. Hemodynamic coherence in patients with burns. Best Pract Res Clin Anaesthesiol. 2016 Dec; 30(4):437-443. PMID: 27931647.
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    66. Chaïbi K, Chaussard M, Soussi S, Lafaurie M, Legrand M. Not all ß-lactams are equal regarding neurotoxicity. Crit Care. 2016 10 27; 20(1):350. PMID: 27784324.
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    67. Legrand M. Should we apply "early" initiation of renal replacement therapy to critically ill patients with acute kidney injury? J Thorac Dis. 2016 Oct; 8(10):E1271-E1273. PMID: 27867605.
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    68. Rossignol P, Legrand M, Kosiborod M, Hollenberg SM, Peacock WF, Emmett M, Epstein M, Kovesdy CP, Yilmaz MB, Stough WG, Gayat E, Pitt B, Zannad F, Mebazaa A. Emergency management of severe hyperkalemia: Guideline for best practice and opportunities for the future. Pharmacol Res. 2016 11; 113(Pt A):585-591. PMID: 27693804.
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    69. Schnell D, Azoulay E, Benoit D, Clouzeau B, Demaret P, Ducassou S, Frange P, Lafaurie M, Legrand M, Meert AP, Mokart D, Naudin J, Pene F, Rabbat A, Raffoux E, Ribaud P, Richard JC, Vincent F, Zahar JR, Darmon M. Management of neutropenic patients in the intensive care unit (NEWBORNS EXCLUDED) recommendations from an expert panel from the French Intensive Care Society (SRLF) with the French Group for Pediatric Intensive Care Emergencies (GFRUP), the French Society of Anesthesia and Intensive Care (SFAR), the French Society of Hematology (SFH), the French Society for Hospital Hygiene (SF2H), and the French Infectious Diseases Society (SPILF). Ann Intensive Care. 2016 Dec; 6(1):90. PMID: 27638133.
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    70. Soussi S, Deniau B, Ferry A, Levé C, Benyamina M, Maurel V, Chaussard M, Le Cam B, Blet A, Mimoun M, Lambert J, Chaouat M, Mebazaa A, Legrand M. Low cardiac index and stroke volume on admission are associated with poor outcome in critically ill burn patients: a retrospective cohort study. Ann Intensive Care. 2016 Dec; 6(1):87. PMID: 27620877.
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    71. Darmon M, Legrand M, Terzi N. Understanding the kidney during acute respiratory failure. Intensive Care Med. 2017 08; 43(8):1144-1147. PMID: 27620295.
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    72. Legrand M, Gits-Muselli M, Boutin L, Garcia-Hermoso D, Maurel V, Soussi S, Benyamina M, Ferry A, Chaussard M, Hamane S, Denis B, Touratier S, Guigue N, Fréalle E, Jeanne M, Shaal JV, Soler C, Mimoun M, Chaouat M, Lafaurie M, Mebazaa A, Bretagne S, Alanio A. Detection of Circulating Mucorales DNA in Critically Ill Burn Patients: Preliminary Report of a Screening Strategy for Early Diagnosis and Treatment. Clin Infect Dis. 2016 Nov 15; 63(10):1312-1317. PMID: 27535951.
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    73. Soussi S, Gallais P, Kachatryan L, Benyamina M, Ferry A, Cupaciu A, Chaussard M, Maurel V, Chaouat M, Mimoun M, Mebazza A, Legrand M. Extracorporeal membrane oxygenation in burn patients with refractory acute respiratory distress syndrome leads to 28 % 90-day survival. Intensive Care Med. 2016 Nov; 42(11):1826-1827. PMID: 27502609.
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    74. Soussi S, Ferry A, Chaussard M, Legrand M. Chloride toxicity in critically ill patients: What's the evidence? Anaesth Crit Care Pain Med. 2017 Apr; 36(2):125-130. PMID: 27476827.
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    75. Ishihara S, Gayat E, Sato N, Arrigo M, Laribi S, Legrand M, Placido R, Manivet P, Cohen-Solal A, Abraham WT, Jessup M, Mebazaa A. Similar hemodynamic decongestion with vasodilators and inotropes: systematic review, meta-analysis, and meta-regression of 35 studies on acute heart failure. Clin Res Cardiol. 2016 Dec; 105(12):971-980. PMID: 27314418.
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    76. Legrand M, Russell R. What's new in focused assessment with sonography: ballistic trauma. Intensive Care Med. 2016 Nov; 42(11):1787-1789. PMID: 27289358.
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    77. Legrand M, Le Cam B, Perbet S, Roger C, Darmon M, Guerci P, Ferry A, Maurel V, Soussi S, Constantin JM, Gayat E, Lefrant JY, Leone M. Urine sodium concentration to predict fluid responsiveness in oliguric ICU patients: a prospective multicenter observational study. Crit Care. 2016 May 29; 20(1):165. PMID: 27236480.
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    78. Ichai C, Vinsonneau C, Souweine B, Armando F, Canet E, Clec'h C, Constantin JM, Darmon M, Duranteau J, Gaillot T, Garnier A, Jacob L, Joannes-Boyau O, Juillard L, Journois D, Lautrette A, Muller L, Legrand M, Lerolle N, Rimmelé T, Rondeau E, Tamion F, Walrave Y, Velly L. Acute kidney injury in the perioperative period and in intensive care units (excluding renal replacement therapies). Ann Intensive Care. 2016 Dec; 6(1):48. PMID: 27230984.
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    79. Ichai C, Vinsonneau C, Souweine B, Armando F, Canet E, Clec'h C, Constantin JM, Darmon M, Duranteau J, Gaillot T, Garnier A, Jacob L, Joannes-Boyau O, Juillard L, Journois D, Lautrette A, Muller L, Legrand M, Lerolle N, Rimmelé T, Rondeau E, Tamion F, Walrave Y, Velly L. Acute kidney injury in the perioperative period and in intensive care units (excluding renal replacement therapies). Anaesth Crit Care Pain Med. 2016 Apr; 35(2):151-65. PMID: 27235292.
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    80. Papaioannou V, Chouvarda I, Gaertner E, Benyamina M, Ferry A, Maurel V, Soussi S, Blet A, Chaouat M, Plaud B, Mebazaa A, Legrand M. Heart rate variability and cardiac baroreflex inhibition-derived index predicts pain perception in burn patients. Burns. 2016 Nov; 42(7):1445-1454. PMID: 27170468.
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    81. Mebazaa A, Laterre PF, Russell JA, Bergmann A, Gattinoni L, Gayat E, Harhay MO, Hartmann O, Hein F, Kjolbye AL, Legrand M, Lewis RJ, Marshall JC, Marx G, Radermacher P, Schroedter M, Scigalla P, Stough WG, Struck J, Van den Berghe G, Yilmaz MB, Angus DC. Designing phase 3 sepsis trials: application of learned experiences from critical care trials in acute heart failure. J Intensive Care. 2016; 4:24. PMID: 27034779.
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    82. Legrand M, Lafaurie M. Use of Prophylactic Antibiotics in Mechanically Ventilated Patients With Burn Injuries. Clin Infect Dis. 2016 06 01; 62(11):1464-5. PMID: 26951574.
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    83. Legrand M, Michel T, Daudon M, Benyamina M, Ferry A, Soussi S, Maurel V, Chaussard M, Chaouat M, Mimoun M, Verine J, Mallet V, Mebazaa A. Risk of oxalate nephropathy with the use of cyanide antidote hydroxocobalamin in critically ill burn patients. Intensive Care Med. 2016 Jun; 42(6):1080-1. PMID: 26891675.
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    84. Plaud B, Lefrant JY. The new Sfar journals are in place. Anaesth Crit Care Pain Med. 2016 Feb; 35(1):1-2. PMID: 26898271.
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    85. Legrand M, Ince C. Intravenous Fluids in AKI: A Mechanistically Guided Approach. Semin Nephrol. 2016 Jan; 36(1):53-61. PMID: 27085735.
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    86. Vinsonneau C, Allain-Launay E, Blayau C, Darmon M, Ducheyron D, Gaillot T, Honore PM, Javouhey E, Krummel T, Lahoche A, Letacon S, Legrand M, Monchi M, Ridel C, Robert R, Schortgen F, Souweine B, Vaillant P, Velly L, Osman D, Van Vong L. Renal replacement therapy in adult and pediatric intensive care : Recommendations by an expert panel from the French Intensive Care Society (SRLF) with the French Society of Anesthesia Intensive Care (SFAR) French Group for Pediatric Intensive Care Emergencies (GFRUP) the French Dialysis Society (SFD). Ann Intensive Care. 2015 Dec; 5(1):58. PMID: 26714808.
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    87. Soussi S, Ferry A, Bahaji M, De Tymowski C, Legrand M. Cross-talk phenomenon during femoral transpulmonary thermodilution in a critically ill patient. Anaesth Crit Care Pain Med. 2016 Feb; 35(1):69-70. PMID: 26667596.
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    88. Soussi S, Sisso F, Maurel V, Oueslati H, Legrand M. Influence of the central venous site on the transpulmonary thermodilution parameters in critically ill burn patients. Burns. 2015 Nov; 41(7):1607-10. PMID: 26771037.
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    89. Leone M, Bechis C, Baumstarck K, Ouattara A, Collange O, Augustin P, Annane D, Arbelot C, Asehnoune K, Baldési O, Bourcier S, Delapierre L, Demory D, Hengy B, Ichai C, Kipnis E, Brasdefer E, Lasocki S, Legrand M, Mimoz O, Rimmelé T, Aliane J, Bertrand PM, Bruder N, Klasen F, Friou E, Lévy B, Martinez O, Peytel E, Piton A, Richter E, Kamel T, Vogler MC, Wallet F, Boufi M, Allaouchiche B, Constantin JM, Martin C, Jaber S, Lefrant JY. Erratum to: Outcome of acute mesenteric ischemia in the intensive care unit: a retrospective, multicenter study of 780 cases. Intensive Care Med. 2015 May; 41(5):966-8. PMID: 25761541.
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    90. Ressaire Q, Padoin C, Chaouat M, Maurel V, Alanio A, Ferry A, Soussi S, Benyamina M, Denis B, Mimoun M, Mebazaa A, Legrand M. Muscle diffusion of liposomal amphotericin B and posaconazole in critically ill burn patients receiving continuous hemodialysis. Intensive Care Med. 2015 May; 41(5):948-9. PMID: 25800585.
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    91. Legrand M, Darmon M, Joannidis M. Fenoldopam and acute kidney injury. JAMA. 2015 Mar 03; 313(9):970-1. PMID: 25734744.
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    92. Leone M, Bechis C, Baumstarck K, Ouattara A, Collange O, Augustin P, Annane D, Arbelot C, Asehnoune K, Baldési O, Bourcier S, Delapierre L, Demory D, Hengy B, Ichai C, Kipnis E, Brasdefer E, Lasocki S, Legrand M, Mimoz O, Rimmelé T, Aliane J, Bertrand PM, Bruder N, Klasen F, Friou E, Lévy B, Martinez O, Peytel E, Piton A, Richter E, Toufik K, Vogler MC, Wallet F, Boufi M, Allaouchiche B, Constantin JM, Martin C, Jaber S, Lefrant JY. Outcome of acute mesenteric ischemia in the intensive care unit: a retrospective, multicenter study of 780 cases. Intensive Care Med. 2015 Apr; 41(4):667-76. PMID: 25731634.
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    93. De Berardinis B, Gaggin HK, Magrini L, Belcher A, Zancla B, Femia A, Simon M, Motiwala S, Bhardwaj A, Parry BA, Nagurney JT, Coudriou C, Legrand M, Sadoune M, Di Somma S, Januzzi JL. Comparison between admission natriuretic peptides, NGAL and sST2 testing for the prediction of worsening renal function in patients with acutely decompensated heart failure. Clin Chem Lab Med. 2015 Mar; 53(4):613-21. PMID: 25473804.
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    94. Legrand M, Jacquemod A, Gayat E, Collet C, Giraudeaux V, Launay JM, Payen D. Erratum to: Failure of renal biomarkers to predict worsening renal function in high-risk patients presenting with oliguria. Intensive Care Med. 2015 Feb; 41(2):386. PMID: 25595354.
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    95. Legrand M, Guttormsen AB, Berger MM. Ten tips for managing critically ill burn patients: follow the RASTAFARI! Intensive Care Med. 2015 Jun; 41(6):1107-9. PMID: 25573501.
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    96. Legrand M, Jacquemod A, Gayat E, Collet C, Giraudeaux V, Launay JM, Payen D. Failure of renal biomarkers to predict worsening renal function in high-risk patients presenting with oliguria. Intensive Care Med. 2015 Jan; 41(1):68-76. PMID: 25465906.
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    97. Legrand M, Darmon M. Biomarkers for AKI improve clinical practice: yes. Intensive Care Med. 2015 Apr; 41(4):615-7. PMID: 25387817.
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    98. Legrand M, De Berardinis B, Gaggin HK, Magrini L, Belcher A, Zancla B, Femia A, Simon M, Motiwala S, Sambhare R, Di Somma S, Mebazaa A, Vaidya VS, Januzzi JL. Evidence of uncoupling between renal dysfunction and injury in cardiorenal syndrome: insights from the BIONICS study. PLoS One. 2014; 9(11):e112313. PMID: 25386851.
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    99. Legrand M, Payen D, Vallée F, Mateo J. Reply: To PMID 24667613. Shock. 2014 Sep; 42(3):279-80. PMID: 25122084.
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    100. Legrand M, Mebazaa A, Ronco C, Januzzi JL. When cardiac failure, kidney dysfunction, and kidney injury intersect in acute conditions: the case of cardiorenal syndrome. Crit Care Med. 2014 Sep; 42(9):2109-17. PMID: 24810531.
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    101. Ronco C, Legrand M, Goldstein SL, Hur M, Tran N, Howell EC, Cantaluppi V, Cruz DN, Damman K, Bagshaw SM, Di Somma S, Lewington A. Neutrophil gelatinase-associated lipocalin: ready for routine clinical use? An international perspective. Blood Purif. 2014; 37(4):271-85. PMID: 25012891; PMCID: PMC4842016.
    102. Legrand M, Vallée F, Mateo J, Payen D. Influence of arterial dissolved oxygen level on venous oxygen saturation: don't forget the PaO2! Shock. 2014 Jun; 41(6):510-3. PMID: 24667613.
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    103. Papaioannou V, Mebazaa A, Plaud B, Legrand M. 'Chronomics' in ICU: circadian aspects of immune response and therapeutic perspectives in the critically ill. Intensive Care Med Exp. 2014 Dec; 2(1):18. PMID: 26266918.
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    104. Legrand M, Payen D. In reply. Anesthesiology. 2014 Jan; 120(1):244-5. PMID: 24398746.
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    105. Legrand M, Plaud B. Etomidate and general anesthesia: the butterfly effect? Anesth Analg. 2013 Dec; 117(6):1267-9. PMID: 24257373.
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    106. Legrand M, Dupuis C, Simon C, Gayat E, Mateo J, Lukaszewicz AC, Payen D. Association between systemic hemodynamics and septic acute kidney injury in critically ill patients: a retrospective observational study. Crit Care. 2013 Nov 29; 17(6):R278. PMID: 24289206.
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    107. Legrand M, Pirracchio R, Rosa A, Petersen ML, Van der Laan M, Fabiani JN, Fernandez-gerlinger MP, Podglajen I, Safran D, Cholley B, Mainardi JL. Incidence, risk factors and prediction of post-operative acute kidney injury following cardiac surgery for active infective endocarditis: an observational study. Crit Care. 2013 Oct 04; 17(5):R220. PMID: 24093498.
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    108. Legrand M, Gayat E. Novelties in biomarkers for the management of circulatory failure. Curr Opin Crit Care. 2013 Oct; 19(5):410-6. PMID: 23995128.
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    109. Legrand M, Darmon M, Joannidis M. NGAL and AKI: the end of a myth? Intensive Care Med. 2013 Oct; 39(10):1861-3. PMID: 23949705.
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    110. Legrand M, Januzzi JL, Mebazaa A. Critical research on biomarkers: what's new? Intensive Care Med. 2013 Oct; 39(10):1824-8. PMID: 23828026.
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