Matthieu Legrand, MD, PhD
|Paris Diderot University, Paris||Full Professor||2017||Anesthesiology and Critical Care Medicine|
|Paris Diderot University, Paris, France||Research director ||2016|
|Paris Diderot University, Paris, France||Associated Professor||2013||Anesthesiology and Critical Care Medicine|
|Paris Diderot University, Paris, France||PhD||2012||Renal physiology|
|Paris Diderot University, Paris, France||Assistant Professor||2010||Anesthesiology and Critical Care Medicine|
|Pierre and Marie Curie University , Paris, France||Residency||2010||Anesthesiology and Critical Care Medicine|
|Paris Diderot University, Paris, France||MSc||2007||Cardiovascular physiology|
|Toulouse Rangueil Univeristy, Toulouse, France||MD||2003|
Dr. Legrand is a clinician scientist practicing critical care medicine and anesthesiology. His professional interests include diagnosing and optimum treatments of shock, the diagnosis, pathophysiology, and treatment of acute kidney injury and metabolic disorders, applied physiology, and bedside medical education. He cares for severely ill patients, including patients with sepsis, after major surgery or any life-threatening condition with the ultimate goal of improving global outcomes and limiting both the short and long-term consequences of critical illnesses. His research interests have been focusing on the development and validation of acute illness biomarkers, mostly in the setting of sepsis and Acute Kidney Injury, intending to improve the non-optimal performance of current diagnostic methods. He has investigated factors associated with poor outcomes in severely ill patients, with a particular interest in hemodynamic factors. He also has investigated the role of the microcirculation in ischemic and sepsis-induced organ injury. He is investigating the use of vaso-active agents - from vasopressors to vasodilators, including modulators of the renin-angiotensin system - to improve outcomes in surgical and critically ill patients.
Dr. Legrand completed his postgraduate training in Anesthesiology and Critical Care from 2003 to 2010 at Pierre and Marie Curie University in Paris, France, receiving his medical degree in 2010. Thereafter, he received a Ph.D. degree in Cardiovascular Physiology from Sorbonne Paris Cite University in 2012. Upon obtaining his medical degree, he was appointed as an Assistant Professor at the Paris Diderot University and was promoted associated to Full Professor of Anesthesiology and Critical Care Medicine in 2017. He also served as the Medical Director of Burn and surgical Intensive Care Units at Saint-Louis Hospital. He is now Professor and director of Clinical research in the department of Anesthesiology and Perioperative medicine of the University of California San Francisco.
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