Philip Insel, PhD, MS

Title(s)Assistant Professor, Psychiatry
SchoolSchool of Medicine
Address401 Parnassus Ave.
San Francisco CA 94143
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    1. Harmonizing tau positron emission tomography in Alzheimer's disease: The CenTauR scale and the joint propagation model. Alzheimers Dement. 2024 Jul 23. Leuzy A, Raket LL, Villemagne VL, Klein G, Tonietto M, Olafson E, Baker S, Saad ZS, Bullich S, Lopresti B, Bohorquez SS, Boada M, Betthauser TJ, Charil A, Collins EC, Collins JA, Cullen N, Gunn RN, Higuchi M, Hostetler E, Hutchison RM, Iaccarino L, Insel PS, Irizarry MC, Jack CR, Jagust WJ, Johnson KA, Johnson SC, Karten Y, Marquié M, Mathotaarachchi S, Mintun MA, Ossenkoppele R, Pappas I, Petersen RC, Rabinovici GD, Rosa-Neto P, Schwarz CG, Smith R, Stephens AW, Whittington A, Carrillo MC, Pontecorvo MJ, Haeberlein SB, Dunn B, Kolb HC, Sivakumaran S, Rowe CC, Hansson O, Doré V. PMID: 39041435.
      View in: PubMed   Mentions:    Fields:    
    2. A generalizable data-driven model of atrophy heterogeneity and progression in memory clinic settings. Brain. 2024 Apr 24. Baumeister H, Vogel JW, Insel PS, Kleineidam L, Wolfsgruber S, Stark M, Gellersen HM, Yakupov R, Schmid MC, Lüsebrink F, Brosseron F, Ziegler G, Freiesleben SD, Preis L, Schneider LS, Spruth EJ, Altenstein S, Lohse A, Fliessbach K, Vogt IR, Bartels C, Schott BH, Rostamzadeh A, Glanz W, Incesoy EI, Butryn M, Janowitz D, Rauchmann BS, Kilimann I, Goerss D, Munk MH, Hetzer S, Dechent P, Ewers M, Scheffler K, Wuestefeld A, Strandberg O, van Westen D, Mattsson-Carlgren N, Janelidze S, Stomrud E, Palmqvist S, Spottke A, Laske C, Teipel S, Perneczky R, Buerger K, Schneider A, Priller J, Peters O, Ramirez A, Wiltfang J, Heneka MT, Wagner M, Düzel E, Jessen F, Hansson O, Berron D. PMID: 38654513.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Speech patterns during memory recall relates to early tau burden across adulthood. Alzheimers Dement. 2024 04; 20(4):2552-2563. Young CB, Smith V, Karjadi C, Grogan SM, Ang TFA, Insel PS, Henderson VW, Sumner M, Poston KL, Au R, Mormino EC. PMID: 38348772; PMCID: PMC11032578.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. Anxiety in late-life depression: Associations with brain volume, amyloid beta, white matter lesions, cognition, and functional ability. Int Psychogeriatr. 2024 Jan 25; 1-12. Kryza-Lacombe M, Kassel MT, Insel PS, Rhodes E, Bickford D, Burns E, Butters MA, Tosun D, Aisen P, Raman R, Landau S, Saykin AJ, Toga AW, Jack CR, Koeppe R, Weiner MW, Nelson C, Mackin RS. PMID: 38268483; PMCID: PMC11269525.
      View in: PubMed   Mentions:    Fields:    
    5. Relationship of Hoarding and Depression Symptoms in Older Adults. Am J Geriatr Psychiatry. 2024 Apr; 32(4):497-508. Nutley S, Nguyen BK, Mackin RS, Insel PS, Tosun D, Butters M, Aisen P, Raman R, Saykin AJ, Toga AW, Jack C, Weiner MW, Nelson C, Kassel M, Kryza-Lacombe M, Eichenbaum J, Nosheny RL, Mathews CA. PMID: 38092621; PMCID: PMC11055473.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Hoarding Symptoms in Late Life Depression are Associated With Greater Executive Dysfunction and Disability and Poorer Response to Depression Treatment. Am J Geriatr Psychiatry. 2024 02; 32(2):137-147. Kassel MT, Kryza-Lacombe M, Insel PS, Rhodes E, Satre DD, Nelson JC, Tosun D, Mathews CA, Mackin RS. PMID: 37770349; PMCID: PMC10872841.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Genetic Moderation of the Association of β-Amyloid With Cognition and MRI Brain Structure in Alzheimer Disease. Neurology. 2023 07 04; 101(1):e20-e29. Insel PS, Kumar A, Hansson O, Mattsson-Carlgren N, Alzheimer's Disease Neuroimaging Initiative. PMID: 37085326; PMCID: PMC10351305.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Tau positron emission tomography in preclinical Alzheimer's disease. Brain. 2023 02 13; 146(2):700-711. Insel PS, Young CB, Aisen PS, Johnson KA, Sperling RA, Mormino EC, Donohue MC. PMID: 35962782; PMCID: PMC10169284.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    9. Natural cubic splines for the analysis of Alzheimer's clinical trials. Pharm Stat. 2023 May-Jun; 22(3):508-519. Donohue MC, Langford O, Insel PS, van Dyck CH, Petersen RC, Craft S, Sethuraman G, Raman R, Aisen PS, Alzheimer's Disease Neuroimaging Initiative. PMID: 36627206; PMCID: PMC10191992.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    10. APOE effects on regional tau in preclinical Alzheimer's disease. Mol Neurodegener. 2023 01 04; 18(1):1. Young CB, Johns E, Kennedy G, Belloy ME, Insel PS, Greicius MD, Sperling RA, Johnson KA, Poston KL, Mormino EC, Alzheimer’s Disease Neuroimaging Initiative, A4 Study Team. PMID: 36597122; PMCID: PMC9811772.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    11. The genetic regulation of protein expression in cerebrospinal fluid. EMBO Mol Med. 2023 01 11; 15(1):e16359. Hansson O, Kumar A, Janelidze S, Stomrud E, Insel PS, Blennow K, Zetterberg H, Fauman E, Hedman ÅK, Nagle MW, Whelan CD, Baird D, Mälarstig A, Mattsson-Carlgren N. PMID: 36504281; PMCID: PMC9832827.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    12. Uncertainties in the PET defined A-/TNeocortical+ subtype. Alzheimers Dement (Amst). 2022; 14(1):e12348. Mormino EC, Insel PS. PMID: 36051175; PMCID: PMC9413468.
      View in: PubMed   Mentions:
    13. Cognitive outcomes are differentially associated with depression severity trajectories during psychotherapy treatment for late life major depressive disorder. Int J Geriatr Psychiatry. 2022 08; 37(8). Kassel MT, Rhodes E, Insel PS, Woodworth K, Garrison-Diehn C, Satre DD, Nelson JC, Tosun D, Mackin RS. PMID: 35822633; PMCID: PMC10162695.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    14. Early stages of tau pathology and its associations with functional connectivity, atrophy and memory. Brain. 2021 10 22; 144(9):2771-2783. Berron D, Vogel JW, Insel PS, Pereira JB, Xie L, Wisse LEM, Yushkevich PA, Palmqvist S, Mattsson-Carlgren N, Stomrud E, Smith R, Strandberg O, Hansson O. PMID: 33725124; PMCID: PMC8557349.
      View in: PubMed   Mentions: 54     Fields:    Translation:Humans
    15. Association of Sleep and β-Amyloid Pathology Among Older Cognitively Unimpaired Adults. JAMA Netw Open. 2021 07 01; 4(7):e2117573. Insel PS, Mohlenhoff BS, Neylan TC, Krystal AD, Mackin RS. PMID: 34297074; PMCID: PMC8303100.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    16. Reliability and Validity of a Home-Based Self-Administered Computerized Test of Learning and Memory Using Speech Recognition. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2022 09; 29(5):867-881. Mackin RS, Rhodes E, Insel PS, Nosheny R, Finley S, Ashford M, Camacho MR, Truran D, Mosca K, Seabrook G, Morrison R, Narayan VA, Weiner M. PMID: 34139954; PMCID: PMC10081827.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    17. A multicenter comparison of [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau PET tracers to detect a common target ROI for differential diagnosis. Eur J Nucl Med Mol Imaging. 2021 07; 48(7):2295-2305. Leuzy A, Pascoal TA, Strandberg O, Insel P, Smith R, Mattsson-Carlgren N, Benedet AL, Cho H, Lyoo CH, La Joie R, Rabinovici GD, Ossenkoppele R, Rosa-Neto P, Hansson O. PMID: 34041562; PMCID: PMC8175317.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    18. Strategies to reduce sample sizes in Alzheimer's disease primary and secondary prevention trials using longitudinal amyloid PET imaging. Alzheimers Res Ther. 2021 04 19; 13(1):82. Lopes Alves I, Heeman F, Collij LE, Salvadó G, Tolboom N, Vilor-Tejedor N, Markiewicz P, Yaqub M, Cash D, Mormino EC, Insel PS, Boellaard R, van Berckel BNM, Lammertsma AA, Barkhof F, Gispert JD. PMID: 33875021; PMCID: PMC8056524.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansPHPublic Health
    19. Association Between Apolipoprotein E ε2 vs ε4, Age, and β-Amyloid in Adults Without Cognitive Impairment. JAMA Neurol. 2021 02 01; 78(2):229-235. Insel PS, Hansson O, Mattsson-Carlgren N. PMID: 33044487; PMCID: PMC7551211.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCTClinical Trials
    20. Mild behavioral impairment and its relation to tau pathology in preclinical Alzheimer's disease. Transl Psychiatry. 2021 01 26; 11(1):76. Johansson M, Stomrud E, Insel PS, Leuzy A, Johansson PM, Smith R, Ismail Z, Janelidze S, Palmqvist S, van Westen D, Mattsson-Carlgren N, Hansson O. PMID: 33500386; PMCID: PMC7838407.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    21. The Impact of Amyloid Burden and APOE on Rates of Cognitive Impairment in Late Life Depression. J Alzheimers Dis. 2021; 80(3):991-1002. Rhodes E, Insel PS, Butters MA, Morin R, Bickford D, Tosun D, Gessert D, Rosen HJ, Aisen P, Raman R, Landau S, Saykin A, Toga A, Jack CR, Weiner MW, Nelson C, Mackin S, Alzheimer’s Disease Neuroimaging Initiative, ADNI Depression Project. PMID: 33682706; PMCID: PMC8935860.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    22. Time between milestone events in the Alzheimer's disease amyloid cascade. Neuroimage. 2021 02 15; 227:117676. Insel PS, Donohue MC, Berron D, Hansson O, Mattsson-Carlgren N. PMID: 33359337.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    23. Reply to: Brain Amyloid Deposition in Late-Life Depression. Biol Psychiatry. 2021 04 15; 89(8):e43-e44. Mackin RS, Insel PS. PMID: 33189331; PMCID: PMC8444625.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    24. Comparing progression biomarkers in clinical trials of early Alzheimer's disease. Ann Clin Transl Neurol. 2020 09; 7(9):1661-1673. Cullen NC, Zetterberg H, Insel PS, Olsson B, Andreasson U, Alzheimer’s Disease Neuroimaging Initiative, Blennow K, Hansson O, Mattsson-Carlgren N. PMID: 32779869; PMCID: PMC7480920.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    25. Late-Life Depression Is Associated With Reduced Cortical Amyloid Burden: Findings From the Alzheimer's Disease Neuroimaging Initiative Depression Project. Biol Psychiatry. 2021 04 15; 89(8):757-765. Mackin RS, Insel PS, Landau S, Bickford D, Morin R, Rhodes E, Tosun D, Rosen HJ, Butters M, Aisen P, Raman R, Saykin A, Toga A, Jack C, Koeppe R, Weiner MW, Nelson C, Alzheimer’s Disease Neuroimaging Initiative and the ADNI Depression Project. PMID: 32980132; PMCID: PMC10165941.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    26. The A4 study: β-amyloid and cognition in 4432 cognitively unimpaired adults. Ann Clin Transl Neurol. 2020 05; 7(5):776-785. Insel PS, Donohue MC, Sperling R, Hansson O, Mattsson-Carlgren N. PMID: 32315118; PMCID: PMC7261742.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    27. Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer's disease. Sci Adv. 2020 04; 6(16):eaaz2387. Mattsson-Carlgren N, Andersson E, Janelidze S, Ossenkoppele R, Insel P, Strandberg O, Zetterberg H, Rosen HJ, Rabinovici G, Chai X, Blennow K, Dage JL, Stomrud E, Smith R, Palmqvist S, Hansson O. PMID: 32426454; PMCID: PMC7159908.
      View in: PubMed   Mentions: 121     Fields:    Translation:AnimalsCells
    28. Neuroanatomical spread of amyloid β and tau in Alzheimer's disease: implications for primary prevention. Brain Commun. 2020; 2(1):fcaa007. Insel PS, Mormino EC, Aisen PS, Thompson WK, Donohue MC. PMID: 32140682; PMCID: PMC7048875.
      View in: PubMed   Mentions: 42  
    29. Depression Severity, but Not Cognitive Impairment or Frailty, is Associated with Disability in Late-Life Depression. Clin Gerontol. 2020 Jul-Sep; 43(4):411-419. Morin RT, Insel P, Bickford D, Nelson C, Mackin RS. PMID: 31865868; PMCID: PMC9187219.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    30. Study partner-reported decline identifies cognitive decline and dementia risk. Ann Clin Transl Neurol. 2019 12; 6(12):2448-2459. Nosheny RL, Jin C, Neuhaus J, Insel PS, Mackin RS, Weiner MW, Alzheimer’s Disease Neuroimaging Initiative investigators. PMID: 31721455; PMCID: PMC6917311.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    31. Cerebrospinal fluid and plasma biomarker trajectories with increasing amyloid deposition in Alzheimer's disease. EMBO Mol Med. 2019 12; 11(12):e11170. Palmqvist S, Insel PS, Stomrud E, Janelidze S, Zetterberg H, Brix B, Eichenlaub U, Dage JL, Chai X, Blennow K, Mattsson N, Hansson O. PMID: 31709776; PMCID: PMC6895602.
      View in: PubMed   Mentions: 132     Fields:    Translation:Humans
    32. β-amyloid pathology and hippocampal atrophy are independently associated with memory function in cognitively healthy elderly. Sci Rep. 2019 08 01; 9(1):11180. Svenningsson AL, Stomrud E, Insel PS, Mattsson N, Palmqvist S, Hansson O. PMID: 31371787; PMCID: PMC6671981.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    33. Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults. Neurobiol Aging. 2019 10; 82:110-119. Nosheny RL, Insel PS, Mattsson N, Tosun D, Buckley S, Truran D, Schuff N, Aisen PS, Weiner MW, Alzheimer's Disease Neuroimaging Initiative. PMID: 31437719; PMCID: PMC7198229.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    34. Determining clinically meaningful decline in preclinical Alzheimer disease. Neurology. 2019 07 23; 93(4):e322-e333. Insel PS, Weiner M, Mackin RS, Mormino E, Lim YY, Stomrud E, Palmqvist S, Masters CL, Maruff PT, Hansson O, Mattsson N. PMID: 31289148; PMCID: PMC6669933.
      View in: PubMed   Mentions: 61     Fields:    Translation:Humans
    35. Latent Classes of Cognitive Functioning Among Depressed Older Adults Without Dementia. J Int Neuropsychol Soc. 2019 09; 25(8):811-820. Morin RT, Insel P, Nelson C, Butters M, Bickford D, Landau S, Saykin A, Weiner M, Mackin RS, ADNI Depression Project. PMID: 31232250; PMCID: PMC6733620.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    36. Somatic and anxiety symptoms of depression are associated with disability in late life depression. Aging Ment Health. 2020 08; 24(8):1225-1228. Morin RT, Nelson C, Bickford D, Insel PS, Mackin RS. PMID: 30945553; PMCID: PMC9183787.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    37. Predicting diagnosis and cognition with 18F-AV-1451 tau PET and structural MRI in Alzheimer's disease. Alzheimers Dement. 2019 04; 15(4):570-580. Mattsson N, Insel PS, Donohue M, Jögi J, Ossenkoppele R, Olsson T, Schöll M, Smith R, Hansson O. PMID: 30639421.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    38. Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease. Neurology. 2019 02 05; 92(6):e601-e612. Ossenkoppele R, Smith R, Ohlsson T, Strandberg O, Mattsson N, Insel PS, Palmqvist S, Hansson O. PMID: 30626656; PMCID: PMC6382060.
      View in: PubMed   Mentions: 113     Fields:    Translation:Humans
    39. Serum Neurofilament Light Chain for Prognosis of Outcome After Cardiac Arrest. JAMA Neurol. 2019 01 01; 76(1):64-71. Moseby-Knappe M, Mattsson N, Nielsen N, Zetterberg H, Blennow K, Dankiewicz J, Dragancea I, Friberg H, Lilja G, Insel PS, Rylander C, Westhall E, Kjaergaard J, Wise MP, Hassager C, Kuiper MA, Stammet P, Wanscher MCJ, Wetterslev J, Erlinge D, Horn J, Pellis T, Cronberg T. PMID: 30383090; PMCID: PMC6440255.
      View in: PubMed   Mentions: 91     Fields:    Translation:Humans
    40. Accurate risk estimation of β-amyloid positivity to identify prodromal Alzheimer's disease: Cross-validation study of practical algorithms. Alzheimers Dement. 2019 02; 15(2):194-204. Palmqvist S, Insel PS, Zetterberg H, Blennow K, Brix B, Stomrud E, Alzheimer's Disease Neuroimaging Initiative, Swedish BioFINDER study, Mattsson N, Hansson O. PMID: 30365928; PMCID: PMC6374284.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    41. Online study partner-reported cognitive decline in the Brain Health Registry. Alzheimers Dement (N Y). 2018; 4:565-574. Nosheny RL, Camacho MR, Insel PS, Flenniken D, Fockler J, Truran D, Finley S, Ulbricht A, Maruff P, Yaffe K, Mackin RS, Weiner MW. PMID: 30386821; PMCID: PMC6205111.
      View in: PubMed   Mentions: 23  
    42. Total Sleep Time Interacts With Age to Predict Cognitive Performance Among Adults. J Clin Sleep Med. 2018 09 15; 14(9):1587-1594. Mohlenhoff BS, Insel PS, Mackin RS, Neylan TC, Flenniken D, Nosheny R, Richards A, Maruff P, Weiner MW. PMID: 30176964; PMCID: PMC6134252.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    43. Effects of APOE ε4 on neuroimaging, cerebrospinal fluid biomarkers, and cognition in prodromal Alzheimer's disease. Neurobiol Aging. 2018 11; 71:81-90. Mattsson N, Eriksson O, Lindberg O, Schöll M, Lampinen B, Nilsson M, Insel PS, Lautner R, Strandberg O, van Westen D, Zetterberg H, Blennow K, Palmqvist S, Stomrud E, Hansson O. PMID: 30107289.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    44. Chronic depressive symptomatology and CSF amyloid beta and tau levels in mild cognitive impairment. Int J Geriatr Psychiatry. 2018 10; 33(10):1305-1311. Gonzales MM, Insel PS, Nelson C, Tosun D, Schöll M, Mattsson N, Sacuiu S, Bickford D, Weiner MW, Mackin RS, Alzheimer's Disease Neuroimaging Initiative. PMID: 29953668.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    45. Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry. Alzheimers Dement (Amst). 2018; 10:573-582. Mackin RS, Insel PS, Truran D, Finley S, Flenniken D, Nosheny R, Ulbright A, Comacho M, Bickford D, Harel B, Maruff P, Weiner MW. PMID: 30406176; PMCID: PMC6215059.
      View in: PubMed   Mentions: 42  
    46. The Brain Health Registry: An internet-based platform for recruitment, assessment, and longitudinal monitoring of participants for neuroscience studies. Alzheimers Dement. 2018 08; 14(8):1063-1076. Weiner MW, Nosheny R, Camacho M, Truran-Sacrey D, Mackin RS, Flenniken D, Ulbricht A, Insel P, Finley S, Fockler J, Veitch D. PMID: 29754989; PMCID: PMC6126911.
      View in: PubMed   Mentions: 66     Fields:    Translation:Humans
    47. Comparing 18F-AV-1451 with CSF t-tau and p-tau for diagnosis of Alzheimer disease. Neurology. 2018 01 30; 90(5):e388-e395. Mattsson N, Smith R, Strandberg O, Palmqvist S, Schöll M, Insel PS, Hägerström D, Ohlsson T, Zetterberg H, Blennow K, Jögi J, Hansson O. PMID: 29321235; PMCID: PMC5791788.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    48. Amyloid pathology in the progression to mild cognitive impairment. Neurobiol Aging. 2018 04; 64:76-84. Insel PS, Hansson O, Mackin RS, Weiner M, Mattsson N, Alzheimer's Disease Neuroimaging Initiative. PMID: 29353101; PMCID: PMC5820200.
      View in: PubMed   Mentions: 10     Fields:    
    49. Serum tau and neurological outcome in cardiac arrest. Ann Neurol. 2017 Nov; 82(5):665-675. Mattsson N, Zetterberg H, Nielsen N, Blennow K, Dankiewicz J, Friberg H, Lilja G, Insel PS, Rylander C, Stammet P, Aneman A, Hassager C, Kjaergaard J, Kuiper M, Pellis T, Wetterslev J, Wise M, Cronberg T. PMID: 28981963; PMCID: PMC5725735.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    50. Preclinical effects of APOE ε4 on cerebrospinal fluid Aβ42 concentrations. Alzheimers Res Ther. 2017 Oct 23; 9(1):87. Lautner R, Insel PS, Skillbäck T, Olsson B, Landén M, Frisoni GB, Herukka SK, Hampel H, Wallin A, Minthon L, Hansson O, Blennow K, Mattsson N, Zetterberg H. PMID: 29061195; PMCID: PMC5654097.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    51. 18F-AV-1451 and CSF T-tau and P-tau as biomarkers in Alzheimer's disease. EMBO Mol Med. 2017 09; 9(9):1212-1223. Mattsson N, Schöll M, Strandberg O, Smith R, Palmqvist S, Insel PS, Hägerström D, Ohlsson T, Zetterberg H, Jögi J, Blennow K, Hansson O. PMID: 28743782; PMCID: PMC5582410.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    52. Time to Amyloid Positivity and Preclinical Changes in Brain Metabolism, Atrophy, and Cognition: Evidence for Emerging Amyloid Pathology in Alzheimer's Disease. Front Neurosci. 2017; 11:281. Insel PS, Ossenkoppele R, Gessert D, Jagust W, Landau S, Hansson O, Weiner MW, Mattsson N, Alzheimer's Disease Neuroimaging Initiative. PMID: 28567001; PMCID: PMC5434146.
      View in: PubMed   Mentions: 35  
    53.  Cortical Atrophy is Associated with Accelerated Cognitive Decline in Mild Cognitive Impairment with Subsyndromal Depression. Am J Geriatr Psychiatry. 2017 Sep; 25(9):980-991. Gonzales MM, Insel PS, Nelson C, Tosun D, Mattsson N, Mueller SG, Sacuiu S, Bickford D, Weiner MW, Mackin RS, Alzheimer's Disease Neuroimaging Initiative. PMID: 28629965; PMCID: PMC10079284.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    54. Cross-validation of optimized composites for preclinical Alzheimer's disease. Alzheimers Dement (N Y). 2017 Jan; 3(1):123-129. Donohue MC, Sun CK, Raman R, Insel PS, Aisen PS, AN-ADNI, AIBL, J-ADNI. PMID: 28758145; PMCID: PMC5527287.
      View in: PubMed   Mentions: 17  
    55. Cerebrospinal fluid tau, neurogranin, and neurofilament light in Alzheimer's disease. EMBO Mol Med. 2016 10; 8(10):1184-1196. Mattsson N, Insel PS, Palmqvist S, Portelius E, Zetterberg H, Weiner M, Blennow K, Hansson O, Alzheimer's Disease Neuroimaging Initiative. PMID: 27534871; PMCID: PMC5048367.
      View in: PubMed   Mentions: 122     Fields:    Translation:Humans
    56. Plasma tau in Alzheimer disease. Neurology. 2016 Oct 25; 87(17):1827-1835. Mattsson N, Zetterberg H, Janelidze S, Insel PS, Andreasson U, Stomrud E, Palmqvist S, Baker D, Tan Hehir CA, Jeromin A, Hanlon D, Song L, Shaw LM, Trojanowski JQ, Weiner MW, Hansson O, Blennow K, ADNI Investigators. PMID: 27694257; PMCID: PMC5089525.
      View in: PubMed   Mentions: 225     Fields:    Translation:Humans
    57. Cognitive and functional changes associated with Aβ pathology and the progression to mild cognitive impairment. Neurobiol Aging. 2016 12; 48:172-181. Insel PS, Donohue MC, Mackin RS, Aisen PS, Hansson O, Weiner MW, Mattsson N, Alzheimer's Disease Neuroimaging Initiative. PMID: 27710807.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    58. Assessing risk for preclinical β-amyloid pathology with APOE, cognitive, and demographic information. Alzheimers Dement (Amst). 2016; 4:76-84. Insel PS, Palmqvist S, Mackin RS, Nosheny RL, Hansson O, Weiner MW, Mattsson N. PMID: 27722193; PMCID: PMC5045949.
      View in: PubMed   Mentions: 32  
    59. Accelerating rates of cognitive decline and imaging markers associated with β-amyloid pathology. Neurology. 2016 05 17; 86(20):1887-96. Insel PS, Mattsson N, Mackin RS, Schöll M, Nosheny RL, Tosun D, Donohue MC, Aisen PS, Jagust WJ, Weiner MW, Alzheimer's Disease Neuroimaging Initiative. PMID: 27164667; PMCID: PMC4873684.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    60. Increased amyloidogenic APP processing in APOE ɛ4-negative individuals with cerebral β-amyloidosis. Nat Commun. 2016 Mar 07; 7:10918. Mattsson N, Insel PS, Palmqvist S, Stomrud E, van Westen D, Minthon L, Zetterberg H, Blennow K, Hansson O. PMID: 26948379; PMCID: PMC4786682.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    61. PATTERNS OF CLINICALLY SIGNIFICANT COGNITIVE IMPAIRMENT IN HOARDING DISORDER. Depress Anxiety. 2016 Mar; 33(3):211-8. Mackin RS, Vigil O, Insel P, Kivowitz A, Kupferman E, Hough CM, Fekri S, Crothers R, Bickford D, Delucchi KL, Mathews CA. PMID: 26474146; PMCID: PMC5520804.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    62. Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2. Alzheimers Dement. 2015 Jul; 11(7):740-56. Jack CR, Barnes J, Bernstein MA, Borowski BJ, Brewer J, Clegg S, Dale AM, Carmichael O, Ching C, DeCarli C, Desikan RS, Fennema-Notestine C, Fjell AM, Fletcher E, Fox NC, Gunter J, Gutman BA, Holland D, Hua X, Insel P, Kantarci K, Killiany RJ, Krueger G, Leung KK, Mackin S, Maillard P, Malone IB, Mattsson N, McEvoy L, Modat M, Mueller S, Nosheny R, Ourselin S, Schuff N, Senjem ML, Simonson A, Thompson PM, Rettmann D, Vemuri P, Walhovd K, Zhao Y, Zuk S, Weiner M. PMID: 26194310; PMCID: PMC4523217.
      View in: PubMed   Mentions: 70     Fields:    Translation:Humans
    63. Evidence for age-associated cognitive decline from Internet game scores. Alzheimers Dement (Amst). 2015 Jun; 1(2):260-7. Geyer J, Insel P, Farzin F, Sternberg D, Hardy JL, Scanlon M, Mungas D, Kramer J, Mackin RS, Weiner MW. PMID: 27239508; PMCID: PMC4876906.
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    64. Predicting Reduction of Cerebrospinal Fluid β-Amyloid 42 in Cognitively Healthy Controls. JAMA Neurol. 2015 May; 72(5):554-60. Mattsson N, Insel PS, Donohue M, Jagust W, Sperling R, Aisen P, Weiner MW, Alzheimer’s Disease Neuroimaging Initiative. PMID: 25775167.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    65. Chronic Depressive Symptomatology in Mild Cognitive Impairment Is Associated with Frontal Atrophy Rate which Hastens Conversion to Alzheimer Dementia. Am J Geriatr Psychiatry. 2016 Feb; 24(2):126-35. Sacuiu S, Insel PS, Mueller S, Tosun D, Mattsson N, Jack CR, DeCarli C, Petersen R, Aisen PS, Weiner MW, Mackin RS, Alzheimer's Disease Neuroimaging Initiative. PMID: 26238228; PMCID: PMC4973623.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    66. Biomarkers and cognitive endpoints to optimize trials in Alzheimer's disease. Ann Clin Transl Neurol. 2015 May; 2(5):534-47. Insel PS, Mattsson N, Mackin RS, Kornak J, Nosheny R, Tosun-Turgut D, Donohue MC, Aisen PS, Weiner MW, Alzheimer's Disease Neuroimaging Initiative. PMID: 26000325; PMCID: PMC4435707.
      View in: PubMed   Mentions: 15     Fields:    
    67. Brain amyloid-β burden is associated with disruption of intrinsic functional connectivity within the medial temporal lobe in cognitively normal elderly. J Neurosci. 2015 Feb 18; 35(7):3240-7. Song Z, Insel PS, Buckley S, Yohannes S, Mezher A, Simonson A, Wilkins S, Tosun D, Mueller S, Kramer JH, Miller BL, Weiner MW. PMID: 25698758; PMCID: PMC4331637.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    68. Brain structure and function as mediators of the effects of amyloid on memory. Neurology. 2015 Mar 17; 84(11):1136-44. Mattsson N, Insel PS, Aisen PS, Jagust W, Mackin S, Weiner M, Alzheimer's Disease Neuroimaging Initiative. PMID: 25681451; PMCID: PMC4371407.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    69. Cerebrospinal fluid α-synuclein and Lewy body-like symptoms in normal controls, mild cognitive impairment, and Alzheimer's disease. J Alzheimers Dis. 2015; 43(3):1007-16. Mackin RS, Insel P, Zhang J, Mohlenhoff B, Galasko D, Weiner M, Mattsson N. PMID: 25125463; PMCID: PMC4350922.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    70. Independent information from cerebrospinal fluid amyloid-β and florbetapir imaging in Alzheimer's disease. Brain. 2015 Mar; 138(Pt 3):772-83. Mattsson N, Insel PS, Donohue M, Landau S, Jagust WJ, Shaw LM, Trojanowski JQ, Zetterberg H, Blennow K, Weiner MW, Alzheimer's Disease Neuroimaging Initiative*. PMID: 25541191; PMCID: PMC4339769.
      View in: PubMed   Mentions: 121     Fields:    Translation:Humans
    71. The transitional association between β-amyloid pathology and regional brain atrophy. Alzheimers Dement. 2015 Oct; 11(10):1171-9. Insel PS, Mattsson N, Donohue MC, Mackin RS, Aisen PS, Jack CR, Shaw LM, Trojanowski JQ, Weiner MW, Alzheimer's Disease Neuroimaging Initiative. PMID: 25499535; PMCID: PMC4461550.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    72. Variables associated with hippocampal atrophy rate in normal aging and mild cognitive impairment. Neurobiol Aging. 2015 Jan; 36(1):273-82. Nosheny RL, Insel PS, Truran D, Schuff N, Jack CR, Aisen PS, Shaw LM, Trojanowski JQ, Weiner MW, Alzheimer's Disease Neuroimaging Initiative. PMID: 25175807; PMCID: PMC5832349.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    73. Diagnostic accuracy of CSF Ab42 and florbetapir PET for Alzheimer's disease. Ann Clin Transl Neurol. 2014 Aug; 1(8):534-43. Mattsson N, Insel PS, Landau S, Jagust W, Donohue M, Shaw LM, Trojanowski JQ, Zetterberg H, Blennow K, Weiner M, Alzheimer's Disease Neuroimaging Initiativea. PMID: 25356425; PMCID: PMC4184556.
      View in: PubMed   Mentions: 55     Fields:    
    74. Emerging β-amyloid pathology and accelerated cortical atrophy. JAMA Neurol. 2014 Jun; 71(6):725-34. Mattsson N, Insel PS, Nosheny R, Tosun D, Trojanowski JQ, Shaw LM, Jack CR, Donohue MC, Weiner MW, Alzheimer’s Disease Neuroimaging Initiative. PMID: 24781145; PMCID: PMC4410966.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    75. Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment. Brain. 2014 May; 137(Pt 5):1550-61. Mattsson N, Tosun D, Insel PS, Simonson A, Jack CR, Beckett LA, Donohue M, Jagust W, Schuff N, Weiner MW, Alzheimer's Disease Neuroimaging Initiative. PMID: 24625697; PMCID: PMC3999717.
      View in: PubMed   Mentions: 93     Fields:    Translation:Humans
    76. Neuroimaging abnormalities in adults with sickle cell anemia: associations with cognition. Neurology. 2014 Mar 11; 82(10):835-41. Mackin RS, Insel P, Truran D, Vichinsky EP, Neumayr LD, Armstrong FD, Gold JI, Kesler K, Brewer J, Weiner MW, Neuropsychological Dysfunction and Neuroimaging Adult Sickle Cell Anemia Study Group. PMID: 24523480; PMCID: PMC3959758.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    77. Differences in prefrontal, limbic, and white matter lesion volumes according to cognitive status in elderly patients with first-onset subsyndromal depression. PLoS One. 2014; 9(1):e87747. Lee JY, Park S, Mackin S, Ewers M, Chui H, Jagust W, Insel PS, Weiner MW. PMID: 24498184; PMCID: PMC3909227.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    78. Effects of baseline CSF α-synuclein on regional brain atrophy rates in healthy elders, mild cognitive impairment and Alzheimer's disease. PLoS One. 2013; 8(12):e85443. Mattsson N, Insel P, Tosun D, Zhang J, Jack CR, Galasko D, Weiner M, Alzheimer’s Disease Neuroimaging Initiative. PMID: 24392009; PMCID: PMC3877372.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    79. Effects of cerebrospinal fluid proteins on brain atrophy rates in cognitively healthy older adults. Neurobiol Aging. 2014 Mar; 35(3):614-22. Mattsson N, Insel P, Nosheny R, Trojanowski JQ, Shaw LM, Jack CR, Tosun D, Weiner M, Alzheimer's Disease Neuroimaging Initiative. PMID: 24094581; PMCID: PMC3864623.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    80. Early indications of future cognitive decline: stable versus declining controls. PLoS One. 2013; 8(9):e74062. Rizk-Jackson A, Insel P, Petersen R, Aisen P, Jack C, Weiner M. PMID: 24040166; PMCID: PMC3767625.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    81. Cognitive reserve associated with FDG-PET in preclinical Alzheimer disease. Neurology. 2013 Mar 26; 80(13):1194-201. Ewers M, Insel PS, Stern Y, Weiner MW, Alzheimer's Disease Neuroimaging Initiative (ADNI). PMID: 23486873; PMCID: PMC3691784.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    82. The effect of subsyndromal symptoms of depression and white matter lesions on disability for individuals with mild cognitive impairment. Am J Geriatr Psychiatry. 2013 Sep; 21(9):906-14. Mackin RS, Insel P, Tosun D, Mueller SG, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Lee JY, Jack CR, Aisen PS, Petersen RC, Weiner MW, Alzheimer's Disease Neuroimaging Initiative. PMID: 23567388; PMCID: PMC5548455.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    83. Patterns of reduced cortical thickness in late-life depression and relationship to psychotherapeutic response. Am J Geriatr Psychiatry. 2013 Aug; 21(8):794-802. Mackin RS, Tosun D, Mueller SG, Lee JY, Insel P, Schuff N, Truran-Sacrey D, Arean P, Nelson JC, Weiner MW. PMID: 23567394; PMCID: PMC3732520.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    84. A composite score for executive functioning, validated in Alzheimer's Disease Neuroimaging Initiative (ADNI) participants with baseline mild cognitive impairment. Brain Imaging Behav. 2012 Dec; 6(4):517-27. Gibbons LE, Carle AC, Mackin RS, Harvey D, Mukherjee S, Insel P, Curtis SM, Mungas D, Crane PK, Alzheimer’s Disease Neuroimaging Initiative. PMID: 22644789; PMCID: PMC3684181.
      View in: PubMed   Mentions: 221     Fields:    Translation:Humans
    85. Development and assessment of a composite score for memory in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Brain Imaging Behav. 2012 Dec; 6(4):502-16. Crane PK, Carle A, Gibbons LE, Insel P, Mackin RS, Gross A, Jones RN, Mukherjee S, Curtis SM, Harvey D, Weiner M, Mungas D, Alzheimer’s Disease Neuroimaging Initiative. PMID: 22782295; PMCID: PMC3806057.
      View in: PubMed   Mentions: 262     Fields:    Translation:Humans
    86. Greater regional brain atrophy rate in healthy elderly subjects with a history of cigarette smoking. Alzheimers Dement. 2012 Nov; 8(6):513-9. Durazzo TC, Insel PS, Weiner MW, Alzheimer Disease Neuroimaging Initiative. PMID: 23102121; PMCID: PMC3484322.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    87. Different associations of white matter lesions with depression and cognition. BMC Neurol. 2012 Aug 25; 12:83. Lee JY, Insel P, Mackin RS, Schuff N, Chui H, DeCarli C, Park KH, Mueller SG, Weiner MW. PMID: 22920586; PMCID: PMC3482604.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    88. CSF biomarker and PIB-PET-derived beta-amyloid signature predicts metabolic, gray matter, and cognitive changes in nondemented subjects. Cereb Cortex. 2012 Sep; 22(9):1993-2004. Ewers M, Insel P, Jagust WJ, Shaw L, Trojanowski JQ, Aisen P, Petersen RC, Schuff N, Weiner MW, Alzheimer’s Disease Neuroimaging Initiative (ADNI). PMID: 22038908; PMCID: PMC3500862.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    89. Impact of apolipoprotein E4-cerebrospinal fluid β-amyloid interaction on hippocampal volume loss over 1 year in mild cognitive impairment. Alzheimers Dement. 2011 Sep; 7(5):514-20. Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Thompson PM, Reiman EM, Jack CR, Fox NC, Jagust WJ, Harvey DJ, Beckett LA, Gamst A, Aisen PS, Petersen RC, Weiner MW, Alzheimer's Disease Neuroimaging Initiative. PMID: 21889115; PMCID: PMC3177162.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    90. Longitudinal stability of subsyndromal symptoms of depression in individuals with mild cognitive impairment: relationship to conversion to dementia after 3 years. Int J Geriatr Psychiatry. 2012 Apr; 27(4):355-63. Mackin RS, Insel P, Aisen PS, Geda YE, Weiner MW, Alzheimer's Disease Neuroimaging Initiative. PMID: 21744390; PMCID: PMC3685477.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    91. Identifying cognitively healthy elderly individuals with subsequent memory decline by using automated MR temporoparietal volumes. Radiology. 2011 Jun; 259(3):844-51. Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang S, Jack CR, Weiner MW, Alzheimer's Disease Neuroimaging Initiative. PMID: 21467255; PMCID: PMC3099048.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    92. Treatment with cholinesterase inhibitors and memantine of patients in the Alzheimer's Disease Neuroimaging Initiative. Arch Neurol. 2011 Jan; 68(1):58-66. Schneider LS, Insel PS, Weiner MW, Alzheimer's Disease Neuroimaging Initiative. PMID: 21220675; PMCID: PMC3259850.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCTClinical Trials
    93. Nonlinear time course of brain volume loss in cognitively normal and impaired elders. Neurobiol Aging. 2012 May; 33(5):845-55. Schuff N, Tosun D, Insel PS, Chiang GC, Truran D, Aisen PS, Jack CR, Weiner MW, Alzheimer's Disease Neuroimaging Initiative. PMID: 20855131; PMCID: PMC3032014.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    94. Characteristics and performance of a modified version of the ADCS-CGIC CIBIC+ for mild cognitive impairment clinical trials. Alzheimer Dis Assoc Disord. 2009 Jul-Sep; 23(3):260-7. Schneider LS, Raman R, Schmitt FA, Doody RS, Insel P, Clark CM, Morris JC, Reisberg B, Petersen RC, Ferris SH. PMID: 19812469; PMCID: PMC2762354.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    95. Efficacy and adverse effects of atypical antipsychotics for dementia: meta-analysis of randomized, placebo-controlled trials. Am J Geriatr Psychiatry. 2006 Mar; 14(3):191-210. Schneider LS, Dagerman K, Insel PS. PMID: 16505124.
      View in: PubMed   Mentions: 260     Fields:    Translation:Humans
    96. Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. JAMA. 2005 Oct 19; 294(15):1934-43. Schneider LS, Dagerman KS, Insel P. PMID: 16234500.
      View in: PubMed   Mentions: 453     Fields:    Translation:Humans
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