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Scott Mackin, PhD

Title(s)Professor, Psychiatry
SchoolSchool of Medicine
Address401 Parnassus Ave.
San Francisco CA 94143
Phone415-476-7067
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Research 
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    Multimodal MRI Characteristics of Psychotherapy Response in Late Life Depression
    NIH/NIMH R01MH101472Jun 1, 2015 - Feb 29, 2020
    Role: Principal Investigator
    Characterizing Cognitive Decline in Late Life Depression: The ADNI-D Project
    NIH R01MH098062Aug 1, 2013 - Jul 31, 2018
    Role: Principal Investigator
    Cognitive and Neuroimaging Predictors of Disability in Late Life Depression
    NIH K08MH081065Sep 1, 2008 - Feb 28, 2014
    Role: Principal Investigator

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    Collapse Clinical Trials

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Effects of sex, race, ethnicity, and education on online aging research participation. Alzheimers Dement (N Y). 2020; 6(1):e12028. Ashford MT, Eichenbaum J, Williams T, Camacho MR, Fockler J, Ulbricht A, Flenniken D, Truran D, Mackin RS, Weiner MW, Nosheny RL. PMID: 32478165.
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    2. Depression Severity, but Not Cognitive Impairment or Frailty, is Associated with Disability in Late-Life Depression. Clin Gerontol. 2020 Jul-Sep; 43(4):411-419. Morin RT, Insel P, Bickford D, Nelson C, Mackin RS. PMID: 31865868.
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    3. Visually mediated functioning improves following treatment of hoarding disorder. J Affect Disord. 2020 Mar 01; 264:310-317. J Zakrzewski J, A Gillett D, R Vigil O, C Smith L, Komaiko K, Chou CY, Y Uhm S, Bain LD, J Stark S, Gause M, Howell G, Vega E, Chan J, B Eckfield M, Y Tsoh J, Delucchi K, Mackin RS, A Mathews C. PMID: 32056766.
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    4. The relationship of frailty and disability with suicidal ideation in late life depression. Aging Ment Health. 2019 Dec 06; 1-6. Bickford D, Morin RT, Woodworth C, Verduzco E, Khan M, Burns E, Nelson JC, Mackin RS. PMID: 31809584.
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    5. Study partner-reported decline identifies cognitive decline and dementia risk. Ann Clin Transl Neurol. 2019 12; 6(12):2448-2459. Nosheny RL, Jin C, Neuhaus J, Insel PS, Mackin RS, Weiner MW. PMID: 31721455.
      View in: PubMed   Mentions:    Fields:    
    6. Determinants of Suicide-related Ideation in Late Life Depression: Associations with Perceived Stress. Clin Gerontol. 2020 Jan-Feb; 43(1):37-45. Bickford D, Morin RT, Nelson JC, Mackin RS. PMID: 31514586.
      View in: PubMed   Mentions:    Fields:    
    7. Comorbidity Profiles Identified in Older Primary Care Patients Who Attempt Suicide. J Am Geriatr Soc. 2019 12; 67(12):2553-2559. Morin RT, Li Y, Mackin RS, Whooley MA, Conwell Y, Byers AL. PMID: 31469184.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Impaired Financial Capacity in Late-Life Depression: Revisiting Associations with Cognitive Functioning. J Int Neuropsychol Soc. 2019 11; 25(10):1088-1093. Morin RT, Gonzales MM, Bickford D, Catalinotto D, Nelson C, Mackin RS. PMID: 31383048.
      View in: PubMed   Mentions:    Fields:    
    9. Determining clinically meaningful decline in preclinical Alzheimer disease. Neurology. 2019 07 23; 93(4):e322-e333. Insel PS, Weiner M, Mackin RS, Mormino E, Lim YY, Stomrud E, Palmqvist S, Masters CL, Maruff PT, Hansson O, Mattsson N. PMID: 31289148.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. Latent Classes of Cognitive Functioning Among Depressed Older Adults Without Dementia. J Int Neuropsychol Soc. 2019 09; 25(8):811-820. Morin RT, Insel P, Nelson C, Butters M, Bickford D, Landau S, Saykin A, Weiner M, Mackin RS. PMID: 31232250.
      View in: PubMed   Mentions: 1     Fields:    
    11. Somatic and anxiety symptoms of depression are associated with disability in late life depression. Aging Ment Health. 2019 Apr 04; 1-4. Morin RT, Nelson C, Bickford D, Insel PS, Mackin RS. PMID: 30945553.
      View in: PubMed   Mentions:    Fields:    
    12. Cognitive Performance in Parkinson's Disease in the Brain Health Registry. J Alzheimers Dis. 2019; 68(3):1029-1038. Cholerton B, Weiner MW, Nosheny RL, Poston KL, Mackin RS, Tian L, Ashford JW, Montine TJ. PMID: 30909225.
      View in: PubMed   Mentions:    Fields:    
    13. Online study partner-reported cognitive decline in the Brain Health Registry. Alzheimers Dement (N Y). 2018; 4:565-574. Nosheny RL, Camacho MR, Insel PS, Flenniken D, Fockler J, Truran D, Finley S, Ulbricht A, Maruff P, Yaffe K, Mackin RS, Weiner MW. PMID: 30386821.
      View in: PubMed   Mentions:
    14. Total Sleep Time Interacts With Age to Predict Cognitive Performance Among Adults. J Clin Sleep Med. 2018 09 15; 14(9):1587-1594. Mohlenhoff BS, Insel PS, Mackin RS, Neylan TC, Flenniken D, Nosheny R, Richards A, Maruff P, Weiner MW. PMID: 30176964.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Randomised clinical trial of community-based peer-led and psychologist-led group treatment for hoarding disorder. BJPsych Open. 2018 Jul; 4(4):285-293. Mathews CA, Mackin RS, Chou CY, Uhm SY, Bain LD, Stark SJ, Gause M, Vigil OR, Franklin J, Salazar M, Plumadore J, Smith LC, Komaiko K, Howell G, Vega E, Chan J, Eckfield MB, Tsoh JY, Delucchi K. PMID: 30083381.
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    16. Chronic depressive symptomatology and CSF amyloid beta and tau levels in mild cognitive impairment. Int J Geriatr Psychiatry. 2018 10; 33(10):1305-1311. Gonzales MM, Insel PS, Nelson C, Tosun D, Schöll M, Mattsson N, Sacuiu S, Bickford D, Weiner MW, Mackin RS. PMID: 29953668.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Screening for Executive Dysfunction in Late-Life Depression: Utility of Trail Making Test and Self-Report Measures. Am J Geriatr Psychiatry. 2018 10; 26(10):1091-1094. Bickford D, Morin RT, Catalinotto D, Mackin RS, Nelson JC. PMID: 30072308.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry. Alzheimers Dement (Amst). 2018; 10:573-582. Mackin RS, Insel PS, Truran D, Finley S, Flenniken D, Nosheny R, Ulbright A, Comacho M, Bickford D, Harel B, Maruff P, Weiner MW. PMID: 30406176.
      View in: PubMed   Mentions:
    19. Detail-oriented visual processing style: Its role in the relationships between early life adversity and hoarding-related dysfunctions. Psychiatry Res. 2018 09; 267:30-36. Chou CY, Mackin RS, Delucchi KL, Mathews CA. PMID: 29883858.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. The Brain Health Registry: An internet-based platform for recruitment, assessment, and longitudinal monitoring of participants for neuroscience studies. Alzheimers Dement. 2018 08; 14(8):1063-1076. Weiner MW, Nosheny R, Camacho M, Truran-Sacrey D, Mackin RS, Flenniken D, Ulbricht A, Insel P, Finley S, Fockler J, Veitch D. PMID: 29754989.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    21. Alcohol and Drug Use Among Older Adults: Associations with Widowhood, Relationship Quality, and Physical Health. J Gerontol B Psychol Sci Soc Sci. 2018 04 16; 73(4):633-635. Satre DD, Bahorik AL, Mackin RS. PMID: 29617916.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Amyloid pathology in the progression to mild cognitive impairment. Neurobiol Aging. 2018 04; 64:76-84. Insel PS, Hansson O, Mackin RS, Weiner M, Mattsson N. PMID: 29353101.
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    23. ?Cortical Atrophy is Associated with Accelerated Cognitive Decline in Mild Cognitive Impairment with Subsyndromal Depression. Am J Geriatr Psychiatry. 2017 Sep; 25(9):980-991. Gonzales MM, Insel PS, Nelson C, Tosun D, Mattsson N, Mueller SG, Sacuiu S, Bickford D, Weiner MW, Mackin RS. PMID: 28629965.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    24. Cognitive and functional changes associated with Aß pathology and the progression to mild cognitive impairment. Neurobiol Aging. 2016 12; 48:172-181. Insel PS, Donohue MC, Mackin RS, Aisen PS, Hansson O, Weiner MW, Mattsson N. PMID: 27710807.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    25. Assessing risk for preclinical ß-amyloid pathology with APOE, cognitive, and demographic information. Alzheimers Dement (Amst). 2016; 4:76-84. Insel PS, Palmqvist S, Mackin RS, Nosheny RL, Hansson O, Weiner MW, Mattsson N. PMID: 27722193.
      View in: PubMed   Mentions:
    26. Comparison of a peer facilitated support group to cognitive behavior therapy: Study protocol for a randomized controlled trial for hoarding disorder. Contemp Clin Trials. 2016 09; 50:98-105. Uhm SY, Tsoh JY, Mackin RS, Gause M, Chan J, Franklin J, Eckfield M, Salazar M, Vigil O, Bain D, Stark S, Vega E, Delucchi KL, Mathews CA. PMID: 27444427.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    27. Accelerating rates of cognitive decline and imaging markers associated with ß-amyloid pathology. Neurology. 2016 05 17; 86(20):1887-96. Insel PS, Mattsson N, Mackin RS, Schöll M, Nosheny RL, Tosun D, Donohue MC, Aisen PS, Jagust WJ, Weiner MW. PMID: 27164667.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    28. PATTERNS OF CLINICALLY SIGNIFICANT COGNITIVE IMPAIRMENT IN HOARDING DISORDER. Depress Anxiety. 2016 Mar; 33(3):211-8. Mackin RS, Vigil O, Insel P, Kivowitz A, Kupferman E, Hough CM, Fekri S, Crothers R, Bickford D, Delucchi KL, Mathews CA. PMID: 26474146.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    29. Evidence for age-associated cognitive decline from Internet game scores. Alzheimers Dement (Amst). 2015 Jun; 1(2):260-7. Geyer J, Insel P, Farzin F, Sternberg D, Hardy JL, Scanlon M, Mungas D, Kramer J, Mackin RS, Weiner MW. PMID: 27239508.
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    30. Neuropsychological and dimensional behavioral trait profiles in Costa Rican ADHD sib pairs: Potential intermediate phenotypes for genetic studies. Am J Med Genet B Neuropsychiatr Genet. 2015 Jun; 168B(4):247-57. Peskin VA, Ordóñez A, Mackin RS, Delucchi K, Monge S, McGough JJ, Chavira DA, Berrocal M, Cheung E, Fournier E, Badner JA, Herrera LD, Mathews CA. PMID: 25832558.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    31. Chronic Depressive Symptomatology in Mild Cognitive Impairment Is Associated with Frontal Atrophy Rate which Hastens Conversion to Alzheimer Dementia. Am J Geriatr Psychiatry. 2016 Feb; 24(2):126-35. Sacuiu S, Insel PS, Mueller S, Tosun D, Mattsson N, Jack CR, DeCarli C, Petersen R, Aisen PS, Weiner MW, Mackin RS. PMID: 26238228.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    32. Biomarkers and cognitive endpoints to optimize trials in Alzheimer's disease. Ann Clin Transl Neurol. 2015 May; 2(5):534-47. Insel PS, Mattsson N, Mackin RS, Kornak J, Nosheny R, Tosun-Turgut D, Donohue MC, Aisen PS, Weiner MW. PMID: 26000325.
      View in: PubMed   Mentions: 7     Fields:    
    33. Cerebrospinal fluid a-synuclein and Lewy body-like symptoms in normal controls, mild cognitive impairment, and Alzheimer's disease. J Alzheimers Dis. 2015; 43(3):1007-16. Mackin RS, Insel P, Zhang J, Mohlenhoff B, Galasko D, Weiner M, Mattsson N. PMID: 25125463.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    34. The transitional association between ß-amyloid pathology and regional brain atrophy. Alzheimers Dement. 2015 Oct; 11(10):1171-9. Insel PS, Mattsson N, Donohue MC, Mackin RS, Aisen PS, Jack CR, Shaw LM, Trojanowski JQ, Weiner MW. PMID: 25499535.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    35. Peripheral antioxidant markers are associated with total hippocampal and CA3/dentate gyrus volume in MDD and healthy controls-preliminary findings. Psychiatry Res. 2014 Dec 30; 224(3):168-74. Lindqvist D, Mueller S, Mellon SH, Su Y, Epel ES, Reus VI, Rosser R, Mahan L, Mackin RS, Yang TT, Wolkowitz OM. PMID: 25266915.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    36. Association of age at depression onset with cognitive functioning in individuals with late-life depression and executive dysfunction. Am J Geriatr Psychiatry. 2014 Dec; 22(12):1633-41. Mackin RS, Nelson JC, Delucchi KL, Raue PJ, Satre DD, Kiosses DN, Alexopoulos GS, Arean PA. PMID: 24680502.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    37. Neuroimaging abnormalities in adults with sickle cell anemia: associations with cognition. Neurology. 2014 Mar 11; 82(10):835-41. Mackin RS, Insel P, Truran D, Vichinsky EP, Neumayr LD, Armstrong FD, Gold JI, Kesler K, Brewer J, Weiner MW. PMID: 24523480.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    38. Cognitive outcomes after psychotherapeutic interventions for major depression in older adults with executive dysfunction. Am J Geriatr Psychiatry. 2014 Dec; 22(12):1496-503. Mackin RS, Nelson JC, Delucchi K, Raue P, Byers A, Barnes D, Satre DD, Yaffe K, Alexopoulos GS, Arean PA. PMID: 24378255.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    39. The effect of subsyndromal symptoms of depression and white matter lesions on disability for individuals with mild cognitive impairment. Am J Geriatr Psychiatry. 2013 Sep; 21(9):906-14. Mackin RS, Insel P, Tosun D, Mueller SG, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Lee JY, Jack CR, Aisen PS, Petersen RC, Weiner MW. PMID: 23567388.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    40. Patterns of reduced cortical thickness in late-life depression and relationship to psychotherapeutic response. Am J Geriatr Psychiatry. 2013 Aug; 21(8):794-802. Mackin RS, Tosun D, Mueller SG, Lee JY, Insel P, Schuff N, Truran-Sacrey D, Arean P, Nelson JC, Weiner MW. PMID: 23567394.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    41. A composite score for executive functioning, validated in Alzheimer's Disease Neuroimaging Initiative (ADNI) participants with baseline mild cognitive impairment. Brain Imaging Behav. 2012 Dec; 6(4):517-27. Gibbons LE, Carle AC, Mackin RS, Harvey D, Mukherjee S, Insel P, Curtis SM, Mungas D, Crane PK. PMID: 22644789.
      View in: PubMed   Mentions: 100     Fields:    Translation:Humans
    42. Development and assessment of a composite score for memory in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Brain Imaging Behav. 2012 Dec; 6(4):502-16. Crane PK, Carle A, Gibbons LE, Insel P, Mackin RS, Gross A, Jones RN, Mukherjee S, Curtis SM, Harvey D, Weiner M, Mungas D. PMID: 22782295.
      View in: PubMed   Mentions: 108     Fields:    Translation:Humans
    43. Dysexecutive and amnesic AD subtypes defined by single indicator and modern psychometric approaches: relationships with SNPs in ADNI. Brain Imaging Behav. 2012 Dec; 6(4):649-60. Mukherjee S, Trittschuh E, Gibbons LE, Mackin RS, Saykin A, Crane PK. PMID: 23161456.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    44. Different associations of white matter lesions with depression and cognition. BMC Neurol. 2012 Aug 25; 12:83. Lee JY, Insel P, Mackin RS, Schuff N, Chui H, DeCarli C, Park KH, Mueller SG, Weiner MW. PMID: 22920586.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    45. Plasma biomarkers of depressive symptoms in older adults. Transl Psychiatry. 2012 Jan 03; 2:e65. Arnold SE, Xie SX, Leung YY, Wang LS, Kling MA, Han X, Kim EJ, Wolk DA, Bennett DA, Chen-Plotkin A, Grossman M, Hu W, Lee VM, Mackin RS, Trojanowski JQ, Wilson RS, Shaw LM. PMID: 22832727.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    46. Patterns of alcohol and drug use among depressed older adults seeking outpatient psychiatric services. Am J Geriatr Psychiatry. 2011 Aug; 19(8):695-703. Satre DD, Sterling SA, Mackin RS, Weisner C. PMID: 21788921.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    47. Differentiating illiteracy from Alzheimer's disease by using neuropsychological assessments. Int Psychogeriatr. 2011 Dec; 23(10):1560-8. Youn JH, Siksou M, Mackin RS, Choi JS, Chey J, Lee JY. PMID: 21777502.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    48. Longitudinal stability of subsyndromal symptoms of depression in individuals with mild cognitive impairment: relationship to conversion to dementia after 3 years. Int J Geriatr Psychiatry. 2012 Apr; 27(4):355-63. Mackin RS, Insel P, Aisen PS, Geda YE, Weiner MW. PMID: 21744390.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    49. The effect of cognitive impairment on mental healthcare costs for individuals with severe psychiatric illness. Am J Geriatr Psychiatry. 2011 Feb; 19(2):176-84. Mackin RS, Delucchi KL, Bennett RW, Areán PA. PMID: 20808129.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    50. Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction: effect on disability. Arch Gen Psychiatry. 2011 Jan; 68(1):33-41. Alexopoulos GS, Raue PJ, Kiosses DN, Mackin RS, Kanellopoulos D, McCulloch C, Areán PA. PMID: 21199963.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    51. Cognitive functioning in individuals with severe compulsive hoarding behaviors and late life depression. Int J Geriatr Psychiatry. 2011 Mar; 26(3):314-21. Mackin RS, Areán PA, Delucchi KL, Mathews CA. PMID: 21319334.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    52. Recruitment of African Americans and Asian Americans with late-life depression and mild cognitive impairment. Am J Geriatr Psychiatry. 2010 Aug; 18(8):734-42. Bistricky SL, Mackin RS, Chu JP, Areán PA. PMID: 20220590.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    53. Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction. Am J Psychiatry. 2010 Nov; 167(11):1391-8. Areán PA, Raue P, Mackin RS, Kanellopoulos D, McCulloch C, Alexopoulos GS. PMID: 20516155.
      View in: PubMed   Mentions: 65     Fields:    Translation:Humans
    54. The sensitivity and specificity of cognitive screening instruments to detect cognitive impairment in older adults with severe psychiatric illness. J Geriatr Psychiatry Neurol. 2010 Jun; 23(2):94-9. Mackin RS, Ayalon L, Feliciano L, Areán PA. PMID: 20101070.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    55. Impaired financial capacity in late life depression is associated with cognitive performance on measures of executive functioning and attention. J Int Neuropsychol Soc. 2009 Sep; 15(5):793-8. Mackin RS, Areán PA. PMID: 19635176.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    56. Incidence and documentation of cognitive impairment among older adults with severe mental illness in a community mental health setting. Am J Geriatr Psychiatry. 2009 Jan; 17(1):75-82. Mackin RS, Areán PA. PMID: 19092314.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    57. Cognitive and psychiatric predictors of medical treatment adherence among older adults in primary care clinics. Int J Geriatr Psychiatry. 2007 Jan; 22(1):55-60. Mackin RS, Areán PA. PMID: 17006873.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    58. Problem solving therapy for the treatment of depression for a patient with Parkinson's disease and mild cognitive impairment: a case study. Neuropsychiatr Dis Treat. 2006 Sep; 2(3):375-9. Mackin RS, Areán P, Elite-Marcandonatou A. PMID: 19412485.
      View in: PubMed   Mentions:
    59. Evidence-based psychotherapeutic interventions for geriatric depression. Psychiatr Clin North Am. 2005 Dec; 28(4):805-20, vii-viii. Mackin RS, Areán PA. PMID: 16325730.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    60. Relationship of the Wender Utah Rating Scale to objective measures of attention. Compr Psychiatry. 2005 Nov-Dec; 46(6):468-71. Mackin RS, Horner MD. PMID: 16275215.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    61. Neuropsychological test performance prior to and following sports-related mild traumatic brain injury. Clin J Sport Med. 2001 Jan; 11(1):23-31. Echemendia RJ, Putukian M, Mackin RS, Julian L, Shoss N. PMID: 11176142.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
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