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Scott Mackin, PhD

Title(s)Professor, Psychiatry
SchoolSchool of Medicine
Phone415-476-7067
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Research 
    Collapse Research Activities and Funding
    Multimodal MRI Characteristics of Psychotherapy Response in Late Life Depression
    NIH/NIMH R01MH101472Jun 1, 2015 - Feb 29, 2020
    Role: Principal Investigator
    Characterizing Cognitive Decline in Late Life Depression: The ADNI-D Project
    NIH R01MH098062Aug 1, 2013 - Jul 31, 2018
    Role: Principal Investigator
    Cognitive and Neuroimaging Predictors of Disability in Late Life Depression
    NIH K08MH081065Sep 1, 2008 - Feb 28, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Morin RT, Insel P, Bickford D, Nelson C, Mackin RS. Depression Severity, but Not Cognitive Impairment or Frailty, is Associated with Disability in Late-Life Depression. Clin Gerontol. 2019 Dec 21; 1-9. PMID: 31865868.
      View in: PubMed
    2. J Zakrzewski J, A Gillett D, R Vigil O, C Smith L, Komaiko K, Chou CY, Y Uhm S, Bain LD, J Stark S, Gause M, Howell G, Vega E, Chan J, B Eckfield M, Y Tsoh J, Delucchi K, Mackin RS, A Mathews C. Visually mediated functioning improves following treatment of hoarding disorder. J Affect Disord. 2020 Mar 01; 264:310-317. PMID: 32056766.
      View in: PubMed
    3. Bickford D, Morin RT, Woodworth C, Verduzco E, Khan M, Burns E, Nelson JC, Mackin RS. The relationship of frailty and disability with suicidal ideation in late life depression. Aging Ment Health. 2019 Dec 06; 1-6. PMID: 31809584.
      View in: PubMed
    4. Nosheny RL, Jin C, Neuhaus J, Insel PS, Mackin RS, Weiner MW. Study partner-reported decline identifies cognitive decline and dementia risk. Ann Clin Transl Neurol. 2019 Dec; 6(12):2448-2459. PMID: 31721455.
      View in: PubMed
    5. Bickford D, Morin RT, Nelson JC, Mackin RS. Determinants of Suicide-related Ideation in Late Life Depression: Associations with Perceived Stress. Clin Gerontol. 2020 Jan-Feb; 43(1):37-45. PMID: 31514586.
      View in: PubMed
    6. Morin RT, Li Y, Mackin RS, Whooley MA, Conwell Y, Byers AL. Comorbidity Profiles Identified in Older Primary Care Patients Who Attempt Suicide. J Am Geriatr Soc. 2019 Dec; 67(12):2553-2559. PMID: 31469184.
      View in: PubMed
    7. Morin RT, Gonzales MM, Bickford D, Catalinotto D, Nelson C, Mackin RS. Impaired Financial Capacity in Late-Life Depression: Revisiting Associations with Cognitive Functioning. J Int Neuropsychol Soc. 2019 Nov; 25(10):1088-1093. PMID: 31383048.
      View in: PubMed
    8. Insel PS, Weiner M, Mackin RS, Mormino E, Lim YY, Stomrud E, Palmqvist S, Masters CL, Maruff PT, Hansson O, Mattsson N. Determining clinically meaningful decline in preclinical Alzheimer disease. Neurology. 2019 07 23; 93(4):e322-e333. PMID: 31289148.
      View in: PubMed
    9. Morin RT, Insel P, Nelson C, Butters M, Bickford D, Landau S, Saykin A, Weiner M, Mackin RS. Latent Classes of Cognitive Functioning Among Depressed Older Adults Without Dementia. J Int Neuropsychol Soc. 2019 Sep; 25(8):811-820. PMID: 31232250.
      View in: PubMed
    10. Morin RT, Nelson C, Bickford D, Insel PS, Mackin RS. Somatic and anxiety symptoms of depression are associated with disability in late life depression. Aging Ment Health. 2019 Apr 04; 1-4. PMID: 30945553.
      View in: PubMed
    11. Cholerton B, Weiner MW, Nosheny RL, Poston KL, Mackin RS, Tian L, Ashford JW, Montine TJ. Cognitive Performance in Parkinson's Disease in the Brain Health Registry. J Alzheimers Dis. 2019; 68(3):1029-1038. PMID: 30909225.
      View in: PubMed
    12. Nosheny RL, Camacho MR, Insel PS, Flenniken D, Fockler J, Truran D, Finley S, Ulbricht A, Maruff P, Yaffe K, Mackin RS, Weiner MW. Online study partner-reported cognitive decline in the Brain Health Registry. Alzheimers Dement (N Y). 2018; 4:565-574. PMID: 30386821.
      View in: PubMed
    13. Mohlenhoff BS, Insel PS, Mackin RS, Neylan TC, Flenniken D, Nosheny R, Richards A, Maruff P, Weiner MW. Total Sleep Time Interacts With Age to Predict Cognitive Performance Among Adults. J Clin Sleep Med. 2018 09 15; 14(9):1587-1594. PMID: 30176964.
      View in: PubMed
    14. Mathews CA, Mackin RS, Chou CY, Uhm SY, Bain LD, Stark SJ, Gause M, Vigil OR, Franklin J, Salazar M, Plumadore J, Smith LC, Komaiko K, Howell G, Vega E, Chan J, Eckfield MB, Tsoh JY, Delucchi K. Randomised clinical trial of community-based peer-led and psychologist-led group treatment for hoarding disorder. BJPsych Open. 2018 Jul; 4(4):285-293. PMID: 30083381.
      View in: PubMed
    15. Gonzales MM, Insel PS, Nelson C, Tosun D, Schöll M, Mattsson N, Sacuiu S, Bickford D, Weiner MW, Mackin RS. Chronic depressive symptomatology and CSF amyloid beta and tau levels in mild cognitive impairment. Int J Geriatr Psychiatry. 2018 10; 33(10):1305-1311. PMID: 29953668.
      View in: PubMed
    16. Bickford D, Morin RT, Catalinotto D, Mackin RS, Nelson JC. Screening for Executive Dysfunction in Late-Life Depression: Utility of Trail Making Test and Self-Report Measures. Am J Geriatr Psychiatry. 2018 10; 26(10):1091-1094. PMID: 30072308.
      View in: PubMed
    17. Mackin RS, Insel PS, Truran D, Finley S, Flenniken D, Nosheny R, Ulbright A, Comacho M, Bickford D, Harel B, Maruff P, Weiner MW. Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry. Alzheimers Dement (Amst). 2018; 10:573-582. PMID: 30406176.
      View in: PubMed
    18. Chou CY, Mackin RS, Delucchi KL, Mathews CA. Detail-oriented visual processing style: Its role in the relationships between early life adversity and hoarding-related dysfunctions. Psychiatry Res. 2018 09; 267:30-36. PMID: 29883858.
      View in: PubMed
    19. Weiner MW, Nosheny R, Camacho M, Truran-Sacrey D, Mackin RS, Flenniken D, Ulbricht A, Insel P, Finley S, Fockler J, Veitch D. The Brain Health Registry: An internet-based platform for recruitment, assessment, and longitudinal monitoring of participants for neuroscience studies. Alzheimers Dement. 2018 08; 14(8):1063-1076. PMID: 29754989.
      View in: PubMed
    20. Satre DD, Bahorik AL, Mackin RS. Alcohol and Drug Use Among Older Adults: Associations with Widowhood, Relationship Quality, and Physical Health. J Gerontol B Psychol Sci Soc Sci. 2018 04 16; 73(4):633-635. PMID: 29617916.
      View in: PubMed
    21. Insel PS, Hansson O, Mackin RS, Weiner M, Mattsson N. Amyloid pathology in the progression to mild cognitive impairment. Neurobiol Aging. 2018 04; 64:76-84. PMID: 29353101.
      View in: PubMed
    22. Gonzales MM, Insel PS, Nelson C, Tosun D, Mattsson N, Mueller SG, Sacuiu S, Bickford D, Weiner MW, Mackin RS. ?Cortical Atrophy is Associated with Accelerated Cognitive Decline in Mild Cognitive Impairment with Subsyndromal Depression. Am J Geriatr Psychiatry. 2017 Sep; 25(9):980-991. PMID: 28629965.
      View in: PubMed
    23. Insel PS, Donohue MC, Mackin RS, Aisen PS, Hansson O, Weiner MW, Mattsson N. Cognitive and functional changes associated with Aß pathology and the progression to mild cognitive impairment. Neurobiol Aging. 2016 12; 48:172-181. PMID: 27710807.
      View in: PubMed
    24. Insel PS, Palmqvist S, Mackin RS, Nosheny RL, Hansson O, Weiner MW, Mattsson N. Assessing risk for preclinical ß-amyloid pathology with APOE, cognitive, and demographic information. Alzheimers Dement (Amst). 2016; 4:76-84. PMID: 27722193.
      View in: PubMed
    25. Uhm SY, Tsoh JY, Mackin RS, Gause M, Chan J, Franklin J, Eckfield M, Salazar M, Vigil O, Bain D, Stark S, Vega E, Delucchi KL, Mathews CA. Comparison of a peer facilitated support group to cognitive behavior therapy: Study protocol for a randomized controlled trial for hoarding disorder. Contemp Clin Trials. 2016 09; 50:98-105. PMID: 27444427.
      View in: PubMed
    26. Insel PS, Mattsson N, Mackin RS, Schöll M, Nosheny RL, Tosun D, Donohue MC, Aisen PS, Jagust WJ, Weiner MW. Accelerating rates of cognitive decline and imaging markers associated with ß-amyloid pathology. Neurology. 2016 05 17; 86(20):1887-96. PMID: 27164667.
      View in: PubMed
    27. Mackin RS, Vigil O, Insel P, Kivowitz A, Kupferman E, Hough CM, Fekri S, Crothers R, Bickford D, Delucchi KL, Mathews CA. PATTERNS OF CLINICALLY SIGNIFICANT COGNITIVE IMPAIRMENT IN HOARDING DISORDER. Depress Anxiety. 2016 Mar; 33(3):211-8. PMID: 26474146.
      View in: PubMed
    28. Geyer J, Insel P, Farzin F, Sternberg D, Hardy JL, Scanlon M, Mungas D, Kramer J, Mackin RS, Weiner MW. Evidence for age-associated cognitive decline from Internet game scores. Alzheimers Dement (Amst). 2015 Jun; 1(2):260-7. PMID: 27239508.
      View in: PubMed
    29. Peskin VA, Ordóñez A, Mackin RS, Delucchi K, Monge S, McGough JJ, Chavira DA, Berrocal M, Cheung E, Fournier E, Badner JA, Herrera LD, Mathews CA. Neuropsychological and dimensional behavioral trait profiles in Costa Rican ADHD sib pairs: Potential intermediate phenotypes for genetic studies. Am J Med Genet B Neuropsychiatr Genet. 2015 Jun; 168B(4):247-57. PMID: 25832558.
      View in: PubMed
    30. Sacuiu S, Insel PS, Mueller S, Tosun D, Mattsson N, Jack CR, DeCarli C, Petersen R, Aisen PS, Weiner MW, Mackin RS. Chronic Depressive Symptomatology in Mild Cognitive Impairment Is Associated with Frontal Atrophy Rate which Hastens Conversion to Alzheimer Dementia. Am J Geriatr Psychiatry. 2016 Feb; 24(2):126-35. PMID: 26238228.
      View in: PubMed
    31. Insel PS, Mattsson N, Mackin RS, Kornak J, Nosheny R, Tosun-Turgut D, Donohue MC, Aisen PS, Weiner MW. Biomarkers and cognitive endpoints to optimize trials in Alzheimer's disease. Ann Clin Transl Neurol. 2015 May; 2(5):534-47. PMID: 26000325.
      View in: PubMed
    32. Mackin RS, Insel P, Zhang J, Mohlenhoff B, Galasko D, Weiner M, Mattsson N. Cerebrospinal fluid a-synuclein and Lewy body-like symptoms in normal controls, mild cognitive impairment, and Alzheimer's disease. J Alzheimers Dis. 2015; 43(3):1007-16. PMID: 25125463.
      View in: PubMed
    33. Insel PS, Mattsson N, Donohue MC, Mackin RS, Aisen PS, Jack CR, Shaw LM, Trojanowski JQ, Weiner MW. The transitional association between ß-amyloid pathology and regional brain atrophy. Alzheimers Dement. 2015 Oct; 11(10):1171-9. PMID: 25499535.
      View in: PubMed
    34. Lindqvist D, Mueller S, Mellon SH, Su Y, Epel ES, Reus VI, Rosser R, Mahan L, Mackin RS, Yang TT, Wolkowitz OM. Peripheral antioxidant markers are associated with total hippocampal and CA3/dentate gyrus volume in MDD and healthy controls-preliminary findings. Psychiatry Res. 2014 Dec 30; 224(3):168-74. PMID: 25266915.
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    35. Mackin RS, Nelson JC, Delucchi KL, Raue PJ, Satre DD, Kiosses DN, Alexopoulos GS, Arean PA. Association of age at depression onset with cognitive functioning in individuals with late-life depression and executive dysfunction. Am J Geriatr Psychiatry. 2014 Dec; 22(12):1633-41. PMID: 24680502.
      View in: PubMed
    36. Mackin RS, Insel P, Truran D, Vichinsky EP, Neumayr LD, Armstrong FD, Gold JI, Kesler K, Brewer J, Weiner MW. Neuroimaging abnormalities in adults with sickle cell anemia: associations with cognition. Neurology. 2014 Mar 11; 82(10):835-41. PMID: 24523480.
      View in: PubMed
    37. Mackin RS, Nelson JC, Delucchi K, Raue P, Byers A, Barnes D, Satre DD, Yaffe K, Alexopoulos GS, Arean PA. Cognitive outcomes after psychotherapeutic interventions for major depression in older adults with executive dysfunction. Am J Geriatr Psychiatry. 2014 Dec; 22(12):1496-503. PMID: 24378255.
      View in: PubMed
    38. Mackin RS, Insel P, Tosun D, Mueller SG, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Lee JY, Jack CR, Aisen PS, Petersen RC, Weiner MW. The effect of subsyndromal symptoms of depression and white matter lesions on disability for individuals with mild cognitive impairment. Am J Geriatr Psychiatry. 2013 Sep; 21(9):906-14. PMID: 23567388.
      View in: PubMed
    39. Mackin RS, Tosun D, Mueller SG, Lee JY, Insel P, Schuff N, Truran-Sacrey D, Arean P, Nelson JC, Weiner MW. Patterns of reduced cortical thickness in late-life depression and relationship to psychotherapeutic response. Am J Geriatr Psychiatry. 2013 Aug; 21(8):794-802. PMID: 23567394.
      View in: PubMed
    40. Mukherjee S, Trittschuh E, Gibbons LE, Mackin RS, Saykin A, Crane PK. Dysexecutive and amnesic AD subtypes defined by single indicator and modern psychometric approaches: relationships with SNPs in ADNI. Brain Imaging Behav. 2012 Dec; 6(4):649-60. PMID: 23161456.
      View in: PubMed
    41. Crane PK, Carle A, Gibbons LE, Insel P, Mackin RS, Gross A, Jones RN, Mukherjee S, Curtis SM, Harvey D, Weiner M, Mungas D. Development and assessment of a composite score for memory in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Brain Imaging Behav. 2012 Dec; 6(4):502-16. PMID: 22782295.
      View in: PubMed
    42. Gibbons LE, Carle AC, Mackin RS, Harvey D, Mukherjee S, Insel P, Curtis SM, Mungas D, Crane PK. A composite score for executive functioning, validated in Alzheimer's Disease Neuroimaging Initiative (ADNI) participants with baseline mild cognitive impairment. Brain Imaging Behav. 2012 Dec; 6(4):517-27. PMID: 22644789.
      View in: PubMed
    43. Lee JY, Insel P, Mackin RS, Schuff N, Chui H, DeCarli C, Park KH, Mueller SG, Weiner MW. Different associations of white matter lesions with depression and cognition. BMC Neurol. 2012 Aug 25; 12:83. PMID: 22920586.
      View in: PubMed
    44. Arnold SE, Xie SX, Leung YY, Wang LS, Kling MA, Han X, Kim EJ, Wolk DA, Bennett DA, Chen-Plotkin A, Grossman M, Hu W, Lee VM, Mackin RS, Trojanowski JQ, Wilson RS, Shaw LM. Plasma biomarkers of depressive symptoms in older adults. Transl Psychiatry. 2012 Jan 03; 2:e65. PMID: 22832727.
      View in: PubMed
    45. Satre DD, Sterling SA, Mackin RS, Weisner C. Patterns of alcohol and drug use among depressed older adults seeking outpatient psychiatric services. Am J Geriatr Psychiatry. 2011 Aug; 19(8):695-703. PMID: 21788921.
      View in: PubMed
    46. Youn JH, Siksou M, Mackin RS, Choi JS, Chey J, Lee JY. Differentiating illiteracy from Alzheimer's disease by using neuropsychological assessments. Int Psychogeriatr. 2011 Dec; 23(10):1560-8. PMID: 21777502.
      View in: PubMed
    47. Mackin RS, Insel P, Aisen PS, Geda YE, Weiner MW. Longitudinal stability of subsyndromal symptoms of depression in individuals with mild cognitive impairment: relationship to conversion to dementia after 3 years. Int J Geriatr Psychiatry. 2012 Apr; 27(4):355-63. PMID: 21744390.
      View in: PubMed
    48. Mackin RS, Delucchi KL, Bennett RW, Areán PA. The effect of cognitive impairment on mental healthcare costs for individuals with severe psychiatric illness. Am J Geriatr Psychiatry. 2011 Feb; 19(2):176-84. PMID: 20808129.
      View in: PubMed
    49. Alexopoulos GS, Raue PJ, Kiosses DN, Mackin RS, Kanellopoulos D, McCulloch C, Areán PA. Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction: effect on disability. Arch Gen Psychiatry. 2011 Jan; 68(1):33-41. PMID: 21199963.
      View in: PubMed
    50. Mackin RS, Areán PA, Delucchi KL, Mathews CA. Cognitive functioning in individuals with severe compulsive hoarding behaviors and late life depression. Int J Geriatr Psychiatry. 2011 Mar; 26(3):314-21. PMID: 21319334.
      View in: PubMed
    51. Bistricky SL, Mackin RS, Chu JP, Areán PA. Recruitment of African Americans and Asian Americans with late-life depression and mild cognitive impairment. Am J Geriatr Psychiatry. 2010 Aug; 18(8):734-42. PMID: 20220590.
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    52. Areán PA, Raue P, Mackin RS, Kanellopoulos D, McCulloch C, Alexopoulos GS. Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction. Am J Psychiatry. 2010 Nov; 167(11):1391-8. PMID: 20516155.
      View in: PubMed
    53. Mackin RS, Ayalon L, Feliciano L, Areán PA. The sensitivity and specificity of cognitive screening instruments to detect cognitive impairment in older adults with severe psychiatric illness. J Geriatr Psychiatry Neurol. 2010 Jun; 23(2):94-9. PMID: 20101070.
      View in: PubMed
    54. Mackin RS, Areán PA. Impaired financial capacity in late life depression is associated with cognitive performance on measures of executive functioning and attention. J Int Neuropsychol Soc. 2009 Sep; 15(5):793-8. PMID: 19635176.
      View in: PubMed
    55. Mackin RS, Areán PA. Incidence and documentation of cognitive impairment among older adults with severe mental illness in a community mental health setting. Am J Geriatr Psychiatry. 2009 Jan; 17(1):75-82. PMID: 19092314.
      View in: PubMed
    56. Mackin RS, Areán PA. Cognitive and psychiatric predictors of medical treatment adherence among older adults in primary care clinics. Int J Geriatr Psychiatry. 2007 Jan; 22(1):55-60. PMID: 17006873.
      View in: PubMed
    57. Mackin RS, Areán P, Elite-Marcandonatou A. Problem solving therapy for the treatment of depression for a patient with Parkinson's disease and mild cognitive impairment: a case study. Neuropsychiatr Dis Treat. 2006 Sep; 2(3):375-9. PMID: 19412485.
      View in: PubMed
    58. Mackin RS, Areán PA. Evidence-based psychotherapeutic interventions for geriatric depression. Psychiatr Clin North Am. 2005 Dec; 28(4):805-20, vii-viii. PMID: 16325730.
      View in: PubMed
    59. Mackin RS, Horner MD. Relationship of the Wender Utah Rating Scale to objective measures of attention. Compr Psychiatry. 2005 Nov-Dec; 46(6):468-71. PMID: 16275215.
      View in: PubMed
    60. Echemendia RJ, Putukian M, Mackin RS, Julian L, Shoss N. Neuropsychological test performance prior to and following sports-related mild traumatic brain injury. Clin J Sport Med. 2001 Jan; 11(1):23-31. PMID: 11176142.
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