Norbert Schuff, PhD

TitleAdjunct Professor
InstitutionUniversity of California San Francisco
Address4150 Clement St
San Francisco CA 94121
Phone415-221-4810 ext. 24904
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    Collapse Biography 
    Collapse Education and Training
    University of Heidelberg, GermanyDoctor of Natural Sciences (Dr. rer. nat.)1983Physics and Astronomy
    University of California, San FranciscoPostdoctoral Studies1993Graduate Division
    Collapse Awards and Honors
    Johann Wolfgang Goethe University Frankfurt2002  - 2003Friedrich Merz Foundation Guest-Professorship
    Alzheimer Association1998Individual Research Project Award

    Collapse Overview 
    Collapse Overview
    I am a Professor Emeritus in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. I earned my PhD in Physics from the Ruprecht Karls University of Heidelberg/Germany in 1983. From 1984 to 1992, I developed MRI systems first with Bruker GmbH in Karlsruhe/Germany and later with Varian Associates in Palo Alto, California. In 1993, I joined UCSF.

    I study brain diseases such as Alzheimer's and Parkinson's using imaging. My main interests are improving diagnosis and assessing treatment efficacy. I accomplish this by developing novel computational methods for analyzing brain images using MRI physics as well as modern concepts of probability theory and statistical learning.


    Neurodegenerative diseases

    Professional Interests:
    MRI, statistical learning, information theory, brain aging, Alzheimer's disease, Parkinson's disease

    Education and Training:
    • Bachelor of Science: University of Heidelberg, Germany - Physics and Astronomy
    • Masters of Science: University of Heidelberg, Germany - Physics and Astronomy
    • Doctor of Physics: University of Heidelberg, Germany - Physics
    • Research Assistant: Max Planck Institute for Medical Research, Germany
    • Postdoctoral Fellowship: University of California, San Francisco - Radiology

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Simuni T, Siderowf A, Lasch S, Coffey CS, Caspell-Garcia C, Jennings D, Tanner CM, Trojanowski JQ, Shaw LM, Seibyl J, Schuff N, Singleton A, Kieburtz K, Toga AW, Mollenhauer B, Galasko D, Chahine LM, Weintraub D, Foroud T, Tosun D, Poston K, Arnedo V, Frasier M, Sherer T, Chowdhury S, Marek K. Longitudinal change of clinical and biological measures in early Parkinson's disease: Parkinson's progression markers initiative cohort. Mov Disord. 2018 Mar 23. PMID: 29572948.
      View in: PubMed
    2. Binney RJ, Pankov A, Marx G, He X, McKenna F, Staffaroni AM, Kornak J, Attygalle S, Boxer AL, Schuff N, Gorno-Tempini ML, Weiner MW, Kramer JH, Miller BL, Rosen HJ. Data-driven regions of interest for longitudinal change in three variants of frontotemporal lobar degeneration. Brain Behav. 2017 Apr; 7(4):e00675. PMID: 28413716.
      View in: PubMed
    3. Lemasson B, Pannetier N, Coquery N, Boisserand LS, Collomb N, Schuff N, Moseley M, Zaharchuk G, Barbier EL, Christen T. MR Vascular Fingerprinting in Stroke and Brain Tumors Models. Sci Rep. 2016 11 24; 6:37071. PMID: 27883015.
      View in: PubMed
    4. Zhang Y, Wu IW, Tosun D, Foster E, Schuff N. Progression of Regional Microstructural Degeneration in Parkinson's Disease: A Multicenter Diffusion Tensor Imaging Study. PLoS One. 2016; 11(10):e0165540. PMID: 27798653.
      View in: PubMed
    5. Dutt S, Binney RJ, Heuer HW, Luong P, Attygalle S, Bhatt P, Marx GA, Elofson J, Tartaglia MC, Litvan I, McGinnis SM, Dickerson BC, Kornak J, Waltzman D, Voltarelli L, Schuff N, Rabinovici GD, Kramer JH, Jack CR, Miller BL, Rosen HJ, Boxer AL. Progression of brain atrophy in PSP and CBS over 6 months and 1 year. Neurology. 2016 Nov 08; 87(19):2016-2025. PMID: 27742814.
      View in: PubMed
    6. Tosun D, Schuff N, Rabinovici GD, Ayakta N, Miller BL, Jagust W, Kramer J, Weiner MM, Rosen HJ. Diagnostic utility of ASL-MRI and FDG-PET in the behavioral variant of FTD and AD. Ann Clin Transl Neurol. 2016 Oct; 3(10):740-751. PMID: 27752510.
      View in: PubMed
    7. Zhang Y, Walter R, Ng P, Luong PN, Dutt S, Heuer H, Rojas-Rodriguez JC, Tsai R, Litvan I, Dickerson BC, Tartaglia MC, Rabinovici G, Miller BL, Rosen HJ, Schuff N, Boxer AL. Progression of Microstructural Degeneration in Progressive Supranuclear Palsy and Corticobasal Syndrome: A Longitudinal Diffusion Tensor Imaging Study. PLoS One. 2016; 11(6):e0157218. PMID: 27310132.
      View in: PubMed
    8. Tosun D, Schuff N, Jagust W, Weiner MW. Discriminative Power of Arterial Spin Labeling Magnetic Resonance Imaging and 18F-Fluorodeoxyglucose Positron Emission Tomography Changes for Amyloid-ß-Positive Subjects in the Alzheimer's Disease Continuum. Neurodegener Dis. 2016; 16(1-2):87-94. PMID: 26560336.
      View in: PubMed
    9. Teipel S, Drzezga A, Grothe MJ, Barthel H, Chételat G, Schuff N, Skudlarski P, Cavedo E, Frisoni GB, Hoffmann W, Thyrian JR, Fox C, Minoshima S, Sabri O, Fellgiebel A. Multimodal imaging in Alzheimer's disease: validity and usefulness for early detection. Lancet Neurol. 2015 Oct; 14(10):1037-53. PMID: 26318837.
      View in: PubMed
    10. Pankov A, Binney RJ, Staffaroni AM, Kornak J, Attygalle S, Schuff N, Weiner MW, Kramer JH, Dickerson BC, Miller BL, Rosen HJ. Data-driven regions of interest for longitudinal change in frontotemporal lobar degeneration. Neuroimage Clin. 2016; 12:332-40. PMID: 27547726.
      View in: PubMed
    11. Schuff N, Wu IW, Buckley S, Foster ED, Coffey CS, Gitelman DR, Mendick S, Seibyl J, Simuni T, Zhang Y, Jankovic J, Hunter C, Tanner CM, Rees L, Factor S, Berg D, Wurster I, Gauss K, Sprenger F, Seppi K, Poewe W, Mollenhauer B, Knake S, Mari Z, McCoy A, Ranola M, Marek K. Diffusion imaging of nigral alterations in early Parkinson's disease with dopaminergic deficits. Mov Disord. 2015 Dec; 30(14):1885-92. PMID: 26260437.
      View in: PubMed
    12. Jack CR, Barnes J, Bernstein MA, Borowski BJ, Brewer J, Clegg S, Dale AM, Carmichael O, Ching C, DeCarli C, Desikan RS, Fennema-Notestine C, Fjell AM, Fletcher E, Fox NC, Gunter J, Gutman BA, Holland D, Hua X, Insel P, Kantarci K, Killiany RJ, Krueger G, Leung KK, Mackin S, Maillard P, Malone IB, Mattsson N, McEvoy L, Modat M, Mueller S, Nosheny R, Ourselin S, Schuff N, Senjem ML, Simonson A, Thompson PM, Rettmann D, Vemuri P, Walhovd K, Zhao Y, Zuk S, Weiner M. Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2. Alzheimers Dement. 2015 Jul; 11(7):740-56. PMID: 26194310; PMCID: PMC4523217.
    13. Naasan G, Rabinovici GD, Ghosh P, Elofson JD, Miller BL, Coppola G, Karydas A, Fong J, Perry D, Lee SE, Yokoyama JS, Seeley WW, Kramer JH, Weiner MW, Schuff N, Jagust WJ, Grinberg LT, Pribadi M, Yang Z, Sears R, Klein E, Wojta K, Rosen HJ. Amyloid in dementia associated with familial FTLD: not an innocent bystander. Neurocase. 2016; 22(1):76-83. PMID: 26040468; PMCID: PMC4662906 [Available on 02/01/17].
    14. Zhang Y, Wu IW, Buckley S, Coffey CS, Foster E, Mendick S, Seibyl J, Schuff N. Diffusion tensor imaging of the nigrostriatal fibers in Parkinson's disease. Mov Disord. 2015 Aug; 30(9):1229-36. PMID: 25920732; PMCID: PMC4418199.
    15. Friedman EJ, Young K, Tremper G, Liang J, Landsberg AS, Schuff N. Directed network motifs in Alzheimer's disease and mild cognitive impairment. PLoS One. 2015; 10(4):e0124453. PMID: 25879535.
      View in: PubMed
    16. Iglesias JE, Van Leemput K, Bhatt P, Casillas C, Dutt S, Schuff N, Truran-Sacrey D, Boxer A, Fischl B. Bayesian segmentation of brainstem structures in MRI. Neuroimage. 2015 Jun; 113:184-95. PMID: 25776214; PMCID: PMC4434226.
    17. Pannetier NA, Stavrinos T, Ng P, Herbst M, Zaitsev M, Young K, Matson G, Schuff N. Quantitative framework for prospective motion correction evaluation. Magn Reson Med. 2016 Feb; 75(2):810-6. PMID: 25761550; PMCID: PMC4567538 [Available on 02/01/17].
    18. Lam F, Liu D, Song Z, Schuff N, Liang ZP. A fast algorithm for denoising magnitude diffusion-weighted images with rank and edge constraints. Magn Reson Med. 2016 Jan; 75(1):433-40. PMID: 25733066; PMCID: PMC4558386 [Available on 01/01/17].
    19. Bott NT, Johnson ET, Schuff N, Galifianakis N, Subas T, Pollock J, Pressman P, Kramer JH, Possin KL. Sensitive measures of executive dysfunction in non-demented Parkinson's disease. Parkinsonism Relat Disord. 2014 Dec; 20(12):1430-3. PMID: 25454318; PMCID: PMC4314390.
    20. Nosheny RL, Insel PS, Truran D, Schuff N, Jack CR, Aisen PS, Shaw LM, Trojanowski JQ, Weiner MW. Variables associated with hippocampal atrophy rate in normal aging and mild cognitive impairment. Neurobiol Aging. 2015 Jan; 36(1):273-82. PMID: 25175807.
      View in: PubMed
    21. Friedman EJ, Young K, Asif D, Jutla I, Liang M, Wilson S, Landsberg AS, Schuff N. Directed progression brain networks in Alzheimer's disease: properties and classification. Brain Connect. 2014 Jun; 4(5):384-93. PMID: 24901258; PMCID: PMC4064803.
    22. Mattsson N, Tosun D, Insel PS, Simonson A, Jack CR, Beckett LA, Donohue M, Jagust W, Schuff N, Weiner MW. Association of brain amyloid-ß with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment. Brain. 2014 May; 137(Pt 5):1550-61. PMID: 24625697.
      View in: PubMed
    23. Lam F, Babacan SD, Haldar JP, Weiner MW, Schuff N, Liang ZP. Denoising diffusion-weighted magnitude MR images using rank and edge constraints. Magn Reson Med. 2014 Mar; 71(3):1272-84. PMID: 23568755; PMCID: PMC3796128.
    24. Christen T, Pannetier NA, Ni WW, Qiu D, Moseley ME, Schuff N, Zaharchuk G. MR vascular fingerprinting: A new approach to compute cerebral blood volume, mean vessel radius, and oxygenation maps in the human brain. Neuroimage. 2014 Apr 01; 89:262-70. PMID: 24321559; PMCID: PMC3940168.
    25. Ewers M, Brendel M, Rizk-Jackson A, Rominger A, Bartenstein P, Schuff N, Weiner MW. Reduced FDG-PET brain metabolism and executive function predict clinical progression in elderly healthy subjects. Neuroimage Clin. 2014; 4:45-52. PMID: 24286024; PMCID: PMC3841292.
    26. Pannetier NA, Sohlin M, Christen T, Schad L, Schuff N. Numerical modeling of susceptibility-related MR signal dephasing with vessel size measurement: phantom validation at 3T. Magn Reson Med. 2014 Sep; 72(3):646-58. PMID: 24167116; PMCID: PMC3999331.
    27. Liu X, Tosun D, Weiner MW, Schuff N. Locally linear embedding (LLE) for MRI based Alzheimer's disease classification. Neuroimage. 2013 Dec; 83:148-57. PMID: 23792982; PMCID: PMC3815961.
    28. Zhang Y, Schuff N, Camacho M, Chao LL, Fletcher TP, Yaffe K, Woolley SC, Madison C, Rosen HJ, Miller BL, Weiner MW. MRI markers for mild cognitive impairment: comparisons between white matter integrity and gray matter volume measurements. PLoS One. 2013; 8(6):e66367. PMID: 23762488; PMCID: PMC3675142.
    29. Protas HD, Chen K, Langbaum JB, Fleisher AS, Alexander GE, Lee W, Bandy D, de Leon MJ, Mosconi L, Buckley S, Truran-Sacrey D, Schuff N, Weiner MW, Caselli RJ, Reiman EM. Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-aged persons at 3 levels of genetic risk for Alzheimer disease. JAMA Neurol. 2013 Mar 01; 70(3):320-5. PMID: 23599929; PMCID: PMC3745014.
    30. Cardenas VA, Tosun D, Chao LL, Fletcher PT, Joshi S, Weiner MW, Schuff N. Voxel-wise co-analysis of macro- and microstructural brain alteration in mild cognitive impairment and Alzheimer's disease using anatomical and diffusion MRI. J Neuroimaging. 2014 Sep-Oct; 24(5):435-43. PMID: 23421601; PMCID: PMC3951683.
    31. Naylor MG, Cardenas VA, Tosun D, Schuff N, Weiner M, Schwartzman A. Voxelwise multivariate analysis of multimodality magnetic resonance imaging. Hum Brain Mapp. 2014 Mar; 35(3):831-46. PMID: 23408378; PMCID: PMC4324330.
    32. Mackin RS, Tosun D, Mueller SG, Lee JY, Insel P, Schuff N, Truran-Sacrey D, Arean P, Nelson JC, Weiner MW. Patterns of reduced cortical thickness in late-life depression and relationship to psychotherapeutic response. Am J Geriatr Psychiatry. 2013 Aug; 21(8):794-802. PMID: 23567394; PMCID: PMC3732520.
    33. Mackin RS, Insel P, Tosun D, Mueller SG, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Lee JY, Jack CR, Aisen PS, Petersen RC, Weiner MW. The effect of subsyndromal symptoms of depression and white matter lesions on disability for individuals with mild cognitive impairment. Am J Geriatr Psychiatry. 2013 Sep; 21(9):906-14. PMID: 23567388.
      View in: PubMed
    34. Zhang Y, Tartaglia MC, Schuff N, Chiang GC, Ching C, Rosen HJ, Gorno-Tempini ML, Miller BL, Weiner MW. MRI signatures of brain macrostructural atrophy and microstructural degradation in frontotemporal lobar degeneration subtypes. J Alzheimers Dis. 2013; 33(2):431-44. PMID: 22976075.
      View in: PubMed
    35. Wyman BT, Harvey DJ, Crawford K, Bernstein MA, Carmichael O, Cole PE, Crane PK, DeCarli C, Fox NC, Gunter JL, Hill D, Killiany RJ, Pachai C, Schwarz AJ, Schuff N, Senjem ML, Suhy J, Thompson PM, Weiner M, Jack CR. Standardization of analysis sets for reporting results from ADNI MRI data. Alzheimers Dement. 2013 May; 9(3):332-7. PMID: 23110865.
      View in: PubMed
    36. Gregori J, Schuff N, Kern R, Günther M. T2-based arterial spin labeling measurements of blood to tissue water transfer in human brain. J Magn Reson Imaging. 2013 Feb; 37(2):332-42. PMID: 23019041; PMCID: PMC3554863.
    37. Mackin RS, Insel P, Tosun D, Mueller SG, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Lee JY, Jack CR, Aisen PS, Petersen RC, Weiner MW. The Effect of Subsyndromal Symptoms of Depression and White Matter Lesions on Disability for Individuals With Mild Cognitive Impairment. Am J Geriatr Psychiatry. 2012 Sep 26. PMID: 23018473.
      View in: PubMed
    38. Lee JY, Insel P, Mackin RS, Schuff N, Chui H, DeCarli C, Park KH, Mueller SG, Weiner MW. Different associations of white matter lesions with depression and cognition. BMC Neurol. 2012 Aug 25; 12:83. PMID: 22920586; PMCID: PMC3482604.
    39. Mackin RS, Tosun D, Mueller SG, Lee JY, Insel P, Schuff N, Truran-Sacrey D, Arean P, Nelson JC, Weiner MW. Patterns of Reduced Cortical Thickness in Late-Life Depression and Relationship to Psychotherapeutic Response. Am J Geriatr Psychiatry. 2012 Aug 17. PMID: 22902859.
      View in: PubMed
    40. Haldar JP, Wedeen VJ, Nezamzadeh M, Dai G, Weiner MW, Schuff N, Liang ZP. Improved diffusion imaging through SNR-enhancing joint reconstruction. Magn Reson Med. 2013 Jan; 69(1):277-89. PMID: 22392528; PMCID: PMC3407310.
    41. Chiang GC, Zhan W, Schuff N, Weiner MW. White matter alterations in cognitively normal apoE e2 carriers: insight into Alzheimer resistance? AJNR Am J Neuroradiol. 2012 Aug; 33(7):1392-7. PMID: 22383234; PMCID: PMC3951461.
    42. Liu Y, Zhu X, Feinberg D, Guenther M, Gregori J, Weiner MW, Schuff N. Arterial spin labeling MRI study of age and gender effects on brain perfusion hemodynamics. Magn Reson Med. 2012 Sep; 68(3):912-22. PMID: 22139957.
      View in: PubMed
    43. Ewers M, Insel P, Jagust WJ, Shaw L, Trojanowski JQ, Aisen P, Petersen RC, Schuff N, Weiner MW. CSF biomarker and PIB-PET-derived beta-amyloid signature predicts metabolic, gray matter, and cognitive changes in nondemented subjects. Cereb Cortex. 2012 Sep; 22(9):1993-2004. PMID: 22038908; PMCID: PMC3500862.
    44. Tosun D, Rosen H, Miller BL, Weiner MW, Schuff N. MRI patterns of atrophy and hypoperfusion associations across brain regions in frontotemporal dementia. Neuroimage. 2012 Feb 01; 59(3):2098-109. PMID: 22036676; PMCID: PMC3254855.
    45. Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Thompson PM, Reiman EM, Jack CR, Fox NC, Jagust WJ, Harvey DJ, Beckett LA, Gamst A, Aisen PS, Petersen RC, Weiner MW. Impact of apolipoprotein E4-cerebrospinal fluid ß-amyloid interaction on hippocampal volume loss over 1 year in mild cognitive impairment. Alzheimers Dement. 2011 Sep; 7(5):514-20. PMID: 21889115.
      View in: PubMed
    46. Zhan W, Kang GA, Glass GA, Zhang Y, Shirley C, Millin R, Possin KL, Nezamzadeh M, Weiner MW, Marks WJ, Schuff N. Regional alterations of brain microstructure in Parkinson's disease using diffusion tensor imaging. Mov Disord. 2012 Jan; 27(1):90-7. PMID: 21850668; PMCID: PMC4472452.
    47. Zhang Y, Schuff N, Woolley SC, Chiang GC, Boreta L, Laxamana J, Katz JS, Weiner MW. Progression of white matter degeneration in amyotrophic lateral sclerosis: A diffusion tensor imaging study. Amyotroph Lateral Scler. 2011 Nov; 12(6):421-9. PMID: 21745124; PMCID: PMC3804304.
    48. Zhang Y, Schuff N, Ching C, Tosun D, Zhan W, Nezamzadeh M, Rosen HJ, Kramer JH, Gorno-Tempini ML, Miller BL, Weiner MW. Joint assessment of structural, perfusion, and diffusion MRI in Alzheimer's disease and frontotemporal dementia. Int J Alzheimers Dis. 2011; 2011:546871. PMID: 21760989; PMCID: PMC3132541.
    49. Cardenas VA, Samuelson K, Lenoci M, Studholme C, Neylan TC, Marmar CR, Schuff N, Weiner MW. Changes in brain anatomy during the course of posttraumatic stress disorder. Psychiatry Res. 2011 Aug 30; 193(2):93-100. PMID: 21683556; PMCID: PMC3175765.
    50. Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang S, Jack CR, Weiner MW. Identifying cognitively healthy elderly individuals with subsequent memory decline by using automated MR temporoparietal volumes. Radiology. 2011 Jun; 259(3):844-51. PMID: 21467255; PMCID: PMC3099048.
    51. Tosun D, Schuff N, Mathis CA, Jagust W, Weiner MW. Spatial patterns of brain amyloid-beta burden and atrophy rate associations in mild cognitive impairment. Brain. 2011 Apr; 134(Pt 4):1077-88. PMID: 21429865; PMCID: PMC3069703.
    52. Hua X, Gutman B, Boyle CP, Rajagopalan P, Leow AD, Yanovsky I, Kumar AR, Toga AW, Jack CR, Schuff N, Alexander GE, Chen K, Reiman EM, Weiner MW, Thompson PM. Accurate measurement of brain changes in longitudinal MRI scans using tensor-based morphometry. Neuroimage. 2011 Jul 01; 57(1):5-14. PMID: 21320612.
      View in: PubMed
    53. Jahng GH, Xu S, Weiner MW, Meyerhoff DJ, Park S, Schuff N. DTI studies in patients with Alzheimer's disease, mild cognitive impairment, or normal cognition with evaluation of the intrinsic background gradients. Neuroradiology. 2011 Oct; 53(10):749-62. PMID: 21340578; PMCID: PMC3184226.
    54. Ashford JW, Salehi A, Furst A, Bayley P, Frisoni GB, Jack CR, Sabri O, Adamson MM, Coburn KL, Olichney J, Schuff N, Spielman D, Edland SD, Black S, Rosen A, Kennedy D, Weiner M, Perry G. Imaging the Alzheimer brain. J Alzheimers Dis. 2011; 26 Suppl 3:1-27. PMID: 21971448; PMCID: PMC3760773.
    55. Tosun D, Schuff N, Shaw LM, Trojanowski JQ, Weiner MW. Relationship between CSF biomarkers of Alzheimer's disease and rates of regional cortical thinning in ADNI data. J Alzheimers Dis. 2011; 26 Suppl 3:77-90. PMID: 21971452; PMCID: PMC4587763.
    56. Woolley SC, Zhang Y, Schuff N, Weiner MW, Katz JS. Neuroanatomical correlates of apathy in ALS using 4 Tesla diffusion tensor MRI. Amyotroph Lateral Scler. 2011 Jan; 12(1):52-8. PMID: 21271791.
      View in: PubMed
    57. Geng X, Ross TJ, Gu H, Shin W, Zhan W, Chao YP, Lin CP, Schuff N, Yang Y. Diffeomorphic image registration of diffusion MRI using spherical harmonics. IEEE Trans Med Imaging. 2011 Mar; 30(3):747-58. PMID: 21134814.
      View in: PubMed
    58. Apfel BA, Ross J, Hlavin J, Meyerhoff DJ, Metzler TJ, Marmar CR, Weiner MW, Schuff N, Neylan TC. Hippocampal volume differences in Gulf War veterans with current versus lifetime posttraumatic stress disorder symptoms. Biol Psychiatry. 2011 Mar 15; 69(6):541-8. PMID: 21094937; PMCID: PMC3259803.
    59. Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Jack CR, Aisen PS, Petersen RC, Weiner MW. Hippocampal atrophy rates and CSF biomarkers in elderly APOE2 normal subjects. Neurology. 2010 Nov 30; 75(22):1976-81. PMID: 20980669; PMCID: PMC3014234.
    60. Schuff N, Tosun D, Insel PS, Chiang GC, Truran D, Aisen PS, Jack CR, Weiner MW. Nonlinear time course of brain volume loss in cognitively normal and impaired elders. Neurobiol Aging. 2012 May; 33(5):845-55. PMID: 20855131; PMCID: PMC3032014.
    61. Mueller SG, Schuff N, Yaffe K, Madison C, Miller B, Weiner MW. Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease. Hum Brain Mapp. 2010 Sep; 31(9):1339-47. PMID: 20839293; PMCID: PMC2943433.
    62. Neylan TC, Mueller SG, Wang Z, Metzler TJ, Lenoci M, Truran D, Marmar CR, Weiner MW, Schuff N. Insomnia severity is associated with a decreased volume of the CA3/dentate gyrus hippocampal subfield. Biol Psychiatry. 2010 Sep 01; 68(5):494-6. PMID: 20598672; PMCID: PMC2921477.
    63. Schuff N, Suhy J, Goldman R, Xu Y, Sun Y, Truran-Sacrey D, Murthy A. An MRI substudy of a donepezil clinical trial in mild cognitive impairment. Neurobiol Aging. 2011 Dec; 32(12):2318.e31-41. PMID: 20541841.
      View in: PubMed
    64. Tosun D, Schuff N, Truran-Sacrey D, Shaw LM, Trojanowski JQ, Aisen P, Peterson R, Weiner MW. Relations between brain tissue loss, CSF biomarkers, and the ApoE genetic profile: a longitudinal MRI study. Neurobiol Aging. 2010 Aug; 31(8):1340-54. PMID: 20570401; PMCID: PMC2902689.
    65. Nezamzadeh M, Matson GB, Young K, Weiner MW, Schuff N. Improved pseudo-continuous arterial spin labeling for mapping brain perfusion. J Magn Reson Imaging. 2010 Jun; 31(6):1419-27. PMID: 20512895; PMCID: PMC3121564.
    66. Schuff N, Zhang Y, Zhan W, Lenoci M, Ching C, Boreta L, Mueller SG, Wang Z, Marmar CR, Weiner MW, Neylan TC. Patterns of altered cortical perfusion and diminished subcortical integrity in posttraumatic stress disorder: an MRI study. Neuroimage. 2011 Jan; 54 Suppl 1:S62-8. PMID: 20483375; PMCID: PMC2945438.
    67. Jack CR, Bernstein MA, Borowski BJ, Gunter JL, Fox NC, Thompson PM, Schuff N, Krueger G, Killiany RJ, Decarli CS, Dale AM, Carmichael OW, Tosun D, Weiner MW. Update on the magnetic resonance imaging core of the Alzheimer's disease neuroimaging initiative. Alzheimers Dement. 2010 May; 6(3):212-20. PMID: 20451869.
      View in: PubMed
    68. Tosun D, Mojabi P, Weiner MW, Schuff N. Joint analysis of structural and perfusion MRI for cognitive assessment and classification of Alzheimer's disease and normal aging. Neuroimage. 2010 Aug 01; 52(1):186-97. PMID: 20406691; PMCID: PMC4667806.
    69. Ho AJ, Hua X, Lee S, Leow AD, Yanovsky I, Gutman B, Dinov ID, Leporé N, Stein JL, Toga AW, Jack CR, Bernstein MA, Reiman EM, Harvey DJ, Kornak J, Schuff N, Alexander GE, Weiner MW, Thompson PM. Comparing 3 T and 1.5 T MRI for tracking Alzheimer's disease progression with tensor-based morphometry. Hum Brain Mapp. 2010 Apr; 31(4):499-514. PMID: 19780044; PMCID: PMC2875376.
    70. Leung KK, Barnes J, Ridgway GR, Bartlett JW, Clarkson MJ, Macdonald K, Schuff N, Fox NC, Ourselin S. Automated cross-sectional and longitudinal hippocampal volume measurement in mild cognitive impairment and Alzheimer's disease. Neuroimage. 2010 Jul 15; 51(4):1345-59. PMID: 20230901; PMCID: PMC2873209.
    71. Wang Z, Neylan TC, Mueller SG, Lenoci M, Truran D, Marmar CR, Weiner MW, Schuff N. Magnetic resonance imaging of hippocampal subfields in posttraumatic stress disorder. Arch Gen Psychiatry. 2010 Mar; 67(3):296-303. PMID: 20194830; PMCID: PMC2848481.
    72. Shimizu S, Zhang Y, Laxamana J, Miller BL, Kramer JH, Weiner MW, Schuff N. Concordance and discordance between brain perfusion and atrophy in frontotemporal dementia. Brain Imaging Behav. 2010 Mar; 4(1):46-54. PMID: 20503113; PMCID: PMC2854356.
    73. Rule RR, Schuff N, Miller RG, Weiner MW. Gray matter perfusion correlates with disease severity in ALS. Neurology. 2010 Mar 09; 74(10):821-7. PMID: 20147656; PMCID: PMC2839193.
    74. Hua X, Lee S, Hibar DP, Yanovsky I, Leow AD, Toga AW, Jack CR, Bernstein MA, Reiman EM, Harvey DJ, Kornak J, Schuff N, Alexander GE, Weiner MW, Thompson PM. Mapping Alzheimer's disease progression in 1309 MRI scans: power estimates for different inter-scan intervals. Neuroimage. 2010 May 15; 51(1):63-75. PMID: 20139010; PMCID: PMC2846999.
    75. Mueller SG, Mack WJ, Mungas D, Kramer JH, Cardenas-Nicolson V, Lavretsky H, Greene M, Schuff N, Chui HC, Weiner MW. Influences of lobar gray matter and white matter lesion load on cognition and mood. Psychiatry Res. 2010 Feb 28; 181(2):90-6. PMID: 20074914; PMCID: PMC2814971.
    76. Schuff N. A new sensitive MRI marker for memory deficits in normal aging. Neurology. 2010 Jan 19; 74(3):188-9. PMID: 20054009.
      View in: PubMed
    77. Chao LL, Buckley ST, Kornak J, Schuff N, Madison C, Yaffe K, Miller BL, Kramer JH, Weiner MW. ASL perfusion MRI predicts cognitive decline and conversion from MCI to dementia. Alzheimer Dis Assoc Disord. 2010 Jan-Mar; 24(1):19-27. PMID: 20220321; PMCID: PMC2865220.
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    126. Schuff N, Meyerhoff DJ, Mueller S, Chao L, Sacrey DT, Laxer K, Weiner MW. N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease. Adv Exp Med Biol. 2006; 576:241-62; discussion 361-3. PMID: 16802717; PMCID: PMC1779762.
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    132. Kaiser LG, Schuff N, Cashdollar N, Weiner MW. Age-related glutamate and glutamine concentration changes in normal human brain: 1H MR spectroscopy study at 4 T. Neurobiol Aging. 2005 May; 26(5):665-72. PMID: 15708441; PMCID: PMC2443746.
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    138. Kaiser LG, Schuff N, Cashdollar N, Weiner MW. Scyllo-inositol in normal aging human brain: 1H magnetic resonance spectroscopy study at 4 Tesla. NMR Biomed. 2005 Feb; 18(1):51-5. PMID: 15468140; PMCID: PMC1820854.
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    141. Studholme C, Cardenas V, Blumenfeld R, Schuff N, Rosen HJ, Miller B, Weiner M. Deformation tensor morphometry of semantic dementia with quantitative validation. Neuroimage. 2004 Apr; 21(4):1387-98. PMID: 15050564.
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    142. Kramer JH, Mungas D, Reed BR, Schuff N, Weiner MW, Miller BL, Chui HC. Forgetting in dementia with and without subcortical lacunes. Clin Neuropsychol. 2004 Feb; 18(1):32-40. PMID: 15595356; PMCID: PMC1820864.
    143. Neylan TC, Lenoci M, Rothlind J, Metzler TJ, Schuff N, Du AT, Franklin KW, Weiss DS, Weiner MW, Marmar CR. Attention, learning, and memory in posttraumatic stress disorder. J Trauma Stress. 2004 Feb; 17(1):41-6. PMID: 15027792; PMCID: PMC2366105.
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    145. Neylan TC, Schuff N, Lenoci M, Yehuda R, Weiner MW, Marmar CR. Cortisol levels are positively correlated with hippocampal N-acetylaspartate. Biol Psychiatry. 2003 Nov 15; 54(10):1118-21. PMID: 14625155; PMCID: PMC2733352.
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    147. Boxer AL, Rankin KP, Miller BL, Schuff N, Weiner M, Gorno-Tempini ML, Rosen HJ. Cinguloparietal atrophy distinguishes Alzheimer disease from semantic dementia. Arch Neurol. 2003 Jul; 60(7):949-56. PMID: 12873851.
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    151. Capizzano AA, Vermathen P, Laxer KD, Matson GB, Maudsley AA, Soher BJ, Schuff N, Weiner MW. Multisection proton MR spectroscopy for mesial temporal lobe epilepsy. AJNR Am J Neuroradiol. 2002 Sep; 23(8):1359-68. PMID: 12223379; PMCID: PMC2753243.
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    153. O'Neill J, Schuff N, Marks WJ, Feiwell R, Aminoff MJ, Weiner MW. Quantitative 1H magnetic resonance spectroscopy and MRI of Parkinson's disease. Mov Disord. 2002 Sep; 17(5):917-27. PMID: 12360540.
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    154. Hsu YY, Schuff N, Amend DL, Du AT, Norman D, Chui HC, Jagust WJ, Weiner MW. Quantitative magnetic resonance imaging differences between Alzheimer disease with and without subcortical lacunes. Alzheimer Dis Assoc Disord. 2002 Apr-Jun; 16(2):58-64. PMID: 12040300; PMCID: PMC1820852.
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