Ruby Ghadially, MD

Title(s)Professor, Dermatology
SchoolSchool of Medicine
Address4150 Clement Street, #001
San Francisco CA 94121
Phone415-750-2091 ext. 3373
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    Collapse Biography 
    Collapse Education and Training
    University of Sheffield England1982
    University of TorontoResidency1988Dermatology

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    The role of IL17A and keratinocyte stem cells in human psoriasis.
    NIH I01CX001816Oct 1, 2020 - Sep 30, 2024
    Role: Principal Investigator
    The role of IL17A and keratinocyte stem cells in human psoriasis
    Merit Review 1 I01 CX001816-01A2Oct 1, 2020 - Sep 2, 2024
    Role: Principal Investigator
    Description: We will study the abnormal stem cell behavior underlying psoriasis
    Characterization of Human Epidermal Stem Cells
    NIH I01BX000794Oct 1, 2010 - Sep 30, 2014
    Role: Principal Investigator
    Reversing Epidermal Stem Cell Aging: Role of Bmi-1 and the Stem Cell Niche
    NIH R21AR060651Sep 10, 2010 - May 31, 2013
    Role: Principal Investigator
    Characterization of Epidermal Stem Cells
    NIH R01AR053765Sep 1, 2005 - May 31, 2011
    Role: Principal Investigator
    Epidermal Stem Cells: Age-Related Changes
    NIH R03AR048667Sep 15, 2002 - Aug 31, 2005
    Role: Principal Investigator
    Age-Related Changes in Epidermal Stem Cells
    NIH R03AG020372Sep 30, 2001 - Aug 31, 2003
    Role: Principal Investigator
    NIH K08AR001973Jul 20, 1996 - May 31, 2002
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Short cell cycle duration is a phenotype of human epidermal stem cells. Stem Cell Res Ther. 2024 Mar 13; 15(1):76. Xiao T, Eze UC, Charruyer-Reinwald A, Weisenberger T, Khalifa A, Abegaze B, Schwab GK, Elsabagh RH, Parenteau TR, Kochanowski K, Piper M, Xia Y, Cheng JB, Cho RJ, Ghadially R. PMID: 38475896; PMCID: PMC10935907.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Classification of human chronic inflammatory skin disease based on single-cell immune profiling. Sci Immunol. 2022 04 15; 7(70):eabl9165. Liu Y, Wang H, Taylor M, Cook C, Martínez-Berdeja A, North JP, Harirchian P, Hailer AA, Zhao Z, Ghadially R, Ricardo-Gonzalez RR, Grekin RC, Mauro TM, Kim E, Choi J, Purdom E, Cho RJ, Cheng JB. PMID: 35427179; PMCID: PMC9301819.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    3. Genetic priming of sensory neurons in mice that overexpress PAR2 enhances allergen responsiveness. Proc Natl Acad Sci U S A. 2021 02 23; 118(8). Braz JM, Dembo T, Charruyer A, Ghadially R, Fassett MS, Basbaum AI. PMID: 33602818; PMCID: PMC7923356.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    4. Decreased p53 is associated with a decline in asymmetric stem cell self-renewal in aged human epidermis. Aging Cell. 2021 02; 20(2):e13310. Charruyer A, Weisenberger T, Li H, Khalifa A, Schroeder AW, Belzer A, Ghadially R. PMID: 33524216; PMCID: PMC7884041.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    5. Facial psoriasis in a mask-like distribution. JAAD Case Rep. 2021 Jan; 7:128-130. Zachary CMB, Belzer A, Fackler NP, Shiu J, Smith J, Ghadially R. PMID: 33426251; PMCID: PMC7777451.
      View in: PubMed   Mentions:
    6. Single-Cell Profiling Reveals Divergent, Globally Patterned Immune Responses in Murine Skin Inflammation. iScience. 2020 Oct 23; 23(10):101582. Liu Y, Cook C, Sedgewick AJ, Zhang S, Fassett MS, Ricardo-Gonzalez RR, Harirchian P, Kashem SW, Hanakawa S, Leistico JR, North JP, Taylor MA, Zhang W, Man MQ, Charruyer A, Beliakova-Bethell N, Benz SC, Ghadially R, Mauro TM, Kaplan DH, Kabashima K, Choi J, Song JS, Cho RJ, Cheng JB. PMID: 33205009; PMCID: PMC7648132.
      View in: PubMed   Mentions: 17  
    7. IL-1α, IL-6, and GM-CSF Are Downstream Mediators of IL-17A that Promote Asymmetric Stem Cell Self-Renewal in Human Keratinocytes. J Invest Dermatol. 2021 02; 141(2):458-462.e3. Li H, Charruyer A, Weisenberger T, Khalifa A, Nguyen R, Ghadially R. PMID: 32621824.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    8. Proderm technology: a water- based lipid delivery system for dermatitis that penetrates viable epidermis and has antibacterial effects. BMC Dermatol. 2019 01 22; 19(1):2. Charruyer A, Silvander M, Caputo-Janhager M, Raymond I, Ghadially R. PMID: 30670022; PMCID: PMC6343233.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsCTClinical Trials
    9. Transcriptional Programming of Normal and Inflamed Human Epidermis at Single-Cell Resolution. Cell Rep. 2018 10 23; 25(4):871-883. Cheng JB, Sedgewick AJ, Finnegan AI, Harirchian P, Lee J, Kwon S, Fassett MS, Golovato J, Gray M, Ghadially R, Liao W, Perez White BE, Mauro TM, Mully T, Kim EA, Sbitany H, Neuhaus IM, Grekin RC, Yu SS, Gray JW, Purdom E, Paus R, Vaske CJ, Benz SC, Song JS, Cho RJ. PMID: 30355494; PMCID: PMC6367716.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansCells
    10. Influence of pH on Skin Stem Cells and Their Differentiation. Curr Probl Dermatol. 2018; 54:71-78. Charruyer A, Ghadially R. PMID: 30130775.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    11. Brief Report: Interleukin-17A-Dependent Asymmetric Stem Cell Divisions Are Increased in Human Psoriasis: A Mechanism Underlying Benign Hyperproliferation. Stem Cells. 2017 08; 35(8):2001-2007. Charruyer A, Fong S, Vitcov GG, Sklar S, Tabernik L, Taneja M, Caputo M, Soeung C, Yue L, Uchida Y, Arron ST, Horton KM, Foster RD, Sano S, North JP, Ghadially R. PMID: 28600817.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    12. Phycosaccharide AI, a mixture of alginate polysaccharides, increases stem cell proliferation in aged keratinocytes. Exp Dermatol. 2016 09; 25(9):738-40. Charruyer A, Fong S, Yue L, Arron ST, Ghadially R. PMID: 27095184.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    13. Targeting ALDH1 to decrease tumorigenicity, growth and metastasis of human melanoma. Melanoma Res. 2015 Apr; 25(2):138-48. Yue L, Huang ZM, Fong S, Leong S, Jakowatz JG, Charruyer-Reinwald A, Wei M, Ghadially R. PMID: 25643237.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    14. The CD44+ ALDH+ population of human keratinocytes is enriched for epidermal stem cells with long-term repopulating ability. Stem Cells. 2013 Apr; 31(4):786-99. Szabo AZ, Fong S, Yue L, Zhang K, Strachan LR, Scalapino K, Mancianti ML, Ghadially R. PMID: 23335266; PMCID: PMC4104573.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    15. CD133 is a marker for long-term repopulating murine epidermal stem cells. J Invest Dermatol. 2012 Nov; 132(11):2522-33. Charruyer A, Strachan LR, Yue L, Toth AS, Cecchini G, Mancianti ML, Ghadially R. PMID: 22763787; PMCID: PMC3997791.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    16. 25 years of epidermal stem cell research. J Invest Dermatol. 2012 Mar; 132(3 Pt 2):797-810. Ghadially R. PMID: 22205306; PMCID: PMC3998762.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    17. The role of stem and circulating cells in cancer metastasis. J Surg Oncol. 2011 May 01; 103(6):555-7. Ghadially R. PMID: 21480249.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    18. What's new in dermatology: epidermal stem cells. G Ital Dermatol Venereol. 2011 Feb; 146(1):57-67. Charruyer A, Ghadially R. PMID: 21317858.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    19. Selection of tumorigenic melanoma cells using ALDH. J Invest Dermatol. 2010 Dec; 130(12):2799-808. Boonyaratanakornkit JB, Yue L, Strachan LR, Scalapino KJ, LeBoit PE, Lu Y, Leong SP, Smith JE, Ghadially R. PMID: 20739950; PMCID: PMC5621840.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    20. Limiting dilution analysis of murine epidermal stem cells using an in vivo regeneration assay. Methods Mol Biol. 2010; 585:421-32. Strachan LR, Ghadially R. PMID: 19908020; PMCID: PMC2783164.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    21. Transit-amplifying cell frequency and cell cycle kinetics are altered in aged epidermis. J Invest Dermatol. 2009 Nov; 129(11):2574-83. Charruyer A, Barland CO, Yue L, Wessendorf HB, Lu Y, Lawrence HJ, Mancianti ML, Ghadially R. PMID: 19458632.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    22. Stem cells and tissue-engineered skin. Skin Pharmacol Physiol. 2009; 22(2):55-62. Charruyer A, Ghadially R. PMID: 19188753; PMCID: PMC2709994.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    23. Tiers of clonal organization in the epidermis: the epidermal proliferation unit revisited. Stem Cell Rev. 2008 Sep; 4(3):149-57. Strachan LR, Ghadially R. PMID: 18574734.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    24. Rapid adhesion to collagen isolates murine keratinocytes with limited long-term repopulating ability in vivo despite high clonogenicity in vitro. Stem Cells. 2008 Jan; 26(1):235-43. Strachan LR, Scalapino KJ, Lawrence HJ, Ghadially R. PMID: 17932419.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    25. A new water-based topical carrier with polar skin-lipids. Lipids Health Dis. 2006 May 03; 5:12. Silvander M, Ringstad L, Ghadially R, Sköld T. PMID: 16672068; PMCID: PMC1464131.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    26. Epidermal stem cells. Adv Dermatol. 2005; 21:335-55. Ghadially R. PMID: 16350449.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    27. In search of the elusive epidermal stem cell. Ernst Schering Res Found Workshop. 2005; (54):45-62. Ghadially R. PMID: 16080286.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    28. Imiquimod-induced interleukin-1 alpha stimulation improves barrier homeostasis in aged murine epidermis. J Invest Dermatol. 2004 Feb; 122(2):330-6. Barland CO, Zettersten E, Brown BS, Ye J, Elias PM, Ghadially R. PMID: 15009713.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    29. Measuring stem cell frequency in epidermis: a quantitative in vivo functional assay for long-term repopulating cells. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11412-7. Schneider TE, Barland C, Alex AM, Mancianti ML, Lu Y, Cleaver JE, Lawrence HJ, Ghadially R. PMID: 13679571; PMCID: PMC208771.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    30. Alterations in cytokine regulation in aged epidermis: implications for permeability barrier homeostasis and inflammation. I. IL-1 gene family. Exp Dermatol. 2002 Jun; 11(3):209-16. Ye J, Garg A, Calhoun C, Feingold KR, Elias PM, Ghadially R. PMID: 12102659.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    31. The aged epidermal permeability barrier: basis for functional abnormalities. Clin Geriatr Med. 2002 Feb; 18(1):103-20, vii. Elias PM, Ghadially R. PMID: 11913735.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    32. Testosterone perturbs epidermal permeability barrier homeostasis. J Invest Dermatol. 2001 Mar; 116(3):443-51. Kao JS, Garg A, Mao-Qiang M, Crumrine D, Ghadially R, Feingold KR, Elias PM. PMID: 11231319.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    33. Recessive x-linked ichthyosis: role of cholesterol-sulfate accumulation in the barrier abnormality. J Invest Dermatol. 1998 Nov; 111(5):784-90. Zettersten E, Man MQ, Sato J, Denda M, Farrell A, Ghadially R, Williams ML, Feingold KR, Elias PM. PMID: 9804339.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    34. Aging and the epidermal permeability barrier: implications for contact dermatitis. Am J Contact Dermat. 1998 Sep; 9(3):162-9. Ghadially R. PMID: 9744909.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    35. Optimal ratios of topical stratum corneum lipids improve barrier recovery in chronologically aged skin. J Am Acad Dermatol. 1997 Sep; 37(3 Pt 1):403-8. Zettersten EM, Ghadially R, Feingold KR, Crumrine D, Elias PM. PMID: 9308554.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    36. Stratum corneum structure and function correlates with phenotype in psoriasis. J Invest Dermatol. 1996 Oct; 107(4):558-64. Ghadially R, Reed JT, Elias PM. PMID: 8823361.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    37. Decreased epidermal lipid synthesis accounts for altered barrier function in aged mice. J Invest Dermatol. 1996 May; 106(5):1064-9. Ghadially R, Brown BE, Hanley K, Reed JT, Feingold KR, Elias PM. PMID: 8618040.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    38. Tumours of the skin. IARC Sci Publ. 1996; (126):1-43. Ghadially FN, Ghadially R. PMID: 8875259.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    39. Skin type, but neither race nor gender, influence epidermal permeability barrier function. Arch Dermatol. 1995 Oct; 131(10):1134-8. Reed JT, Ghadially R, Elias PM. PMID: 7574829.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    40. The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model. J Clin Invest. 1995 May; 95(5):2281-90. Ghadially R, Brown BE, Sequeira-Martin SM, Feingold KR, Elias PM. PMID: 7738193; PMCID: PMC295841.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimals
    41. Membrane structural abnormalities in the stratum corneum of the autosomal recessive ichthyoses. J Invest Dermatol. 1992 Dec; 99(6):755-63. Ghadially R, Williams ML, Hou SY, Elias PM. PMID: 1469289.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    42. Exogenous origin of n-alkanes in pathologic scale. Arch Dermatol. 1992 Aug; 128(8):1065-71. Williams ML, Vogel JS, Ghadially R, Brown BE, Elias PM. PMID: 1497360.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    43. Ichthyoses and hyperkeratotic disorders. Dermatol Clin. 1992 Jul; 10(3):597-607. Ghadially R, Chong LP. PMID: 1617817.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    44. Lamellar bodies as delivery systems of hydrolytic enzymes: implications for normal and abnormal desquamation. Br J Dermatol. 1992 Apr; 126(4):337-45. Menon GK, Ghadially R, Williams ML, Elias PM. PMID: 1571254.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    45. Effects of petrolatum on stratum corneum structure and function. J Am Acad Dermatol. 1992 Mar; 26(3 Pt 2):387-96. Ghadially R, Halkier-Sorensen L, Elias PM. PMID: 1564142.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCTClinical Trials
    46. Membrane structures in normal and essential fatty acid-deficient stratum corneum: characterization by ruthenium tetroxide staining and x-ray diffraction. J Invest Dermatol. 1991 Feb; 96(2):215-23. Hou SY, Mitra AK, White SH, Menon GK, Ghadially R, Elias PM. PMID: 1991982.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    47. Anchoring fibrils in a spindle cell squamous carcinoma. J Submicrosc Cytol Pathol. 1989 Apr; 21(2):249-57. Ghadially R, Ghadially FN. PMID: 2752358.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    48. Simple method for purification of phospholipase A from cobra venom. Toxicon. 1969 Sep; 7(2):151-7. Braganca BM, Sambray YM, Ghadially RC. PMID: 5387831.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    49. Myo-Inositol activity of oxidtion products derived from myo-inositol. Arch Biochem Biophys. 1962 Dec; 99:537-8. JOHNSTON JA, GHADIALLY RC, ROBERTS RN, FUHR BW. PMID: 13957897.
      View in: PubMed   Mentions: 1     Fields:    
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