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Raymond Cho, MD, PhD

Title(s)Associate Professor, Dermatology
SchoolSchool of Medicine
Address2340 Sutter Street
San Francisco CA 94115
Phone415-353-7800
ORCID ORCID Icon0000-0001-6090-6603 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Stanford UniversityM.D.2005School of Medicine
    Stanford UniversityPh.D.2003Department of Genetics
    Collapse Awards and Honors
    Leo Foundation2020Foundation Grant
    EBRP/EBMRF2018Epidermolysis Bullosa Research Foundation Award
    Sohana Research Foundation2015Sohana Research Scholar
    Samsung Electronics2013  - 2015SAIT Global Research Outreach Award
    American Skin Association 2012  - 2013Abby S. & Howard P. Milstein Scholar in Melanoma
    Dermatology Foundation2009  - 2012Career Development Award
    American Academy of Dermatology2012Young Investigator Award

    Collapse Overview 
    Collapse Overview
    Dr. Cho investigates the molecular basis of skin disease. He currently develops single-cell molecular fingerprints of unusual skin diseases to identify effective immunomodulatory therapies, in collaboration with the laboratory of Dr. Jeffrey Cheng.

    Dr. Cho's group first reported NOTCH as the most commonly mutated gene in squamous cell cancers of the skin, SUFU loss-of-function as a basis for hereditary infundibulocystic basal cell cancer syndrome, and recurrent mutation of the ZNF750 tumor suppressor in sebaceous carcinoma. His lab also jointly identified APOBEC mutagenesis as the driver for cancer formation in recessive dystrophic epidermolysis bullosa, an inherited blistering disease.

    Receiving both his MD and his PhD in Genetics from the Stanford University School of Medicine, Dr. Cho led the earliest demonstrations of transcriptional profiling, genetic screens, and SNV-based mapping on a whole-genome scale. He subsequently co-founded Ingenuity Systems, a privately funded genetic content and software concern later wholly acquired by Qiagen N.V.

    Dr. Cho has been recognized with the American Academy of Dermatology Young Investigator Award and the Samsung Global Research Outreach Award. He was the Abby S. & Howard P. Milstein Research Scholar in Melanoma and received a Career Development Award from the Dermatology Foundation. He lectures at UCSF and at the Structure and Function of the Skin series in the American Academy of Dermatology's Annual Meeting. In his spare time, Dr. Cho teaches capoeira to golden retrievers.

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. CERKL is upregulated in cutaneous squamous cell carcinoma and maintains cellular sphingolipids and resistance to oxidative stress. Br J Dermatol. 2021 Jan 04. Meyer JM, Lee E, Celli A, Park K, Cho R, Lambert W, Pitchford M, Gordon M, Tsai K, Cleaver J, Arron ST, Mauro TM. PMID: 33393080.
      View in: PubMed   Mentions:    Fields:    
    2. CERKL is Upregulated in Cutaneous Squamous Cell Carcinoma and Maintains Cellular Sphingolipids and Resistance to Oxidative Stress. Br J Dermatol. 2020 Dec 03. Meyer JM, Lee E, Celli A, Park K, Cho R, Lambert W, Pitchford M, Gordon M, Tsai K, Cleaver J, Arron ST, Mauro TM. PMID: 33270220.
      View in: PubMed   Mentions:    Fields:    
    3. Single-Cell Profiling Reveals Divergent, Globally Patterned Immune Responses in Murine Skin Inflammation. iScience. 2020 Oct 23; 23(10):101582. Liu Y, Cook C, Sedgewick AJ, Zhang S, Fassett MS, Ricardo-Gonzalez RR, Harirchian P, Kashem SW, Hanakawa S, Leistico JR, North JP, Taylor MA, Zhang W, Man MQ, Charruyer A, Beliakova-Bethell N, Benz SC, Ghadially R, Mauro TM, Kaplan DH, Kabashima K, Choi J, Song JS, Cho RJ, Cheng JB. PMID: 33205009.
      View in: PubMed   Mentions:
    4. Cells from discarded dressings differentiate chronic from acute wounds in patients with Epidermolysis Bullosa. Sci Rep. 2020 09 15; 10(1):15064. PMID: 32934247.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Pervasive chromosomal instability and karyotype order in tumour evolution. Nature. 2020 11; 587(7832):126-132. Watkins TBK, Lim EL, Petkovic M, Elizalde S, Birkbak NJ, Wilson GA, Moore DA, Grönroos E, Rowan A, Dewhurst SM, Demeulemeester J, Dentro SC, Horswell S, Au L, Haase K, Escudero M, Rosenthal R, Bakir MA, Xu H, Litchfield K, Lu WT, Mourikis TP, Dietzen M, Spain L, Cresswell GD, Biswas D, Lamy P, Nordentoft I, Harbst K, Castro-Giner F, Yates LR, Caramia F, Jaulin F, Vicier C, Tomlinson IPM, Brastianos PK, Cho RJ, Bastian BC, Dyrskjøt L, Jönsson GB, Savas P, Loi S, Campbell PJ, Andre F, Luscombe NM, Steeghs N, Tjan-Heijnen VCG, Szallasi Z, Turajlic S, Jamal-Hanjani M, Van Loo P, Bakhoum SF, Schwarz RF, McGranahan N, Swanton C. PMID: 32879494.
      View in: PubMed   Mentions:    Fields:    
    6. Riemannian geometry and statistical modeling correct for batch effects and control false discoveries in single-cell surface protein count data. Phys Rev E. 2020 Jul; 102(1-1):012409. Zhang S, Leistico JR, Cook C, Liu Y, Cho RJ, Cheng JB, Song JS. PMID: 32794969.
      View in: PubMed   Mentions: 1     Fields:    
    7. Multiregion exome sequencing of ovarian immature teratomas reveals 2N near-diploid genomes, paucity of somatic mutations, and extensive allelic imbalances shared across mature, immature, and disseminated components. Mod Pathol. 2020 06; 33(6):1193-1206. Heskett MB, Sanborn JZ, Boniface C, Goode B, Chapman J, Garg K, Rabban JT, Zaloudek C, Benz SC, Spellman PT, Solomon DA, Cho RJ. PMID: 31911616.
      View in: PubMed   Mentions: 1     Fields:    
    8. Single-Cell Transcriptomics Reveals Spatial and Temporal Turnover of Keratinocyte Differentiation Regulators. Front Genet. 2019; 10:775. Finnegan A, Cho RJ, Luu A, Harirchian P, Lee J, Cheng JB, Song JS. PMID: 31552090.
      View in: PubMed   Mentions:
    9. Loss of ZNF750 in ocular and cutaneous sebaceous carcinoma. J Cutan Pathol. 2019 Oct; 46(10):736-741. North JP, Solomon DA, Golovato J, Bloomer M, Benz SC, Cho RJ. PMID: 31148199.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    10. Genetic Mutations Underlying Phenotypic Plasticity in Basosquamous Carcinoma. J Invest Dermatol. 2019 11; 139(11):2263-2271.e5. Chiang A, Tan CZ, Kuonen F, Hodgkinson LM, Chiang F, Cho RJ, South AP, Tang JY, Chang ALS, Rieger KE, Oro AE, Sarin KY. PMID: 31207229.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. A20 and ABIN1 Suppression of a Keratinocyte Inflammatory Program with a Shared Single-Cell Expression Signature in Diverse Human Rashes. J Invest Dermatol. 2019 06; 139(6):1264-1273. Harirchian P, Lee J, Hilz S, Sedgewick AJ, Perez White BE, Kesling MJ, Mully T, Golovato J, Gray M, Mauro TM, Purdom E, Kim EA, Sbitany H, Bhutani T, Vaske CJ, Benz SC, Cho RJ, Cheng JB. PMID: 30543901.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    12. Transcriptional Programming of Normal and Inflamed Human Epidermis at Single-Cell Resolution. Cell Rep. 2018 10 23; 25(4):871-883. Cheng JB, Sedgewick AJ, Finnegan AI, Harirchian P, Lee J, Kwon S, Fassett MS, Golovato J, Gray M, Ghadially R, Liao W, Perez White BE, Mauro TM, Mully T, Kim EA, Sbitany H, Neuhaus IM, Grekin RC, Yu SS, Gray JW, Purdom E, Paus R, Vaske CJ, Benz SC, Song JS, Cho RJ. PMID: 30355494.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    13. APOBEC mutation drives early-onset squamous cell carcinomas in recessive dystrophic epidermolysis bullosa. Sci Transl Med. 2018 08 22; 10(455). Cho RJ, Alexandrov LB, den Breems NY, Atanasova VS, Farshchian M, Purdom E, Nguyen TN, Coarfa C, Rajapakshe K, Prisco M, Sahu J, Tassone P, Greenawalt EJ, Collisson EA, Wu W, Yao H, Su X, Guttmann-Gruber C, Hofbauer JP, Hashmi R, Fuentes I, Benz SC, Golovato J, Ehli EA, Davis CM, Davies GE, Covington KR, Murrell DF, Salas-Alanis JC, Palisson F, Bruckner AL, Robinson W, Has C, Bruckner-Tuderman L, Titeux M, Jonkman MF, Rashidghamat E, Lwin SM, Mellerio JE, McGrath JA, Bauer JW, Hovnanian A, Tsai KY, South AP. PMID: 30135250.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    14. Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma. Nat Commun. 2018 05 14; 9(1):1894. North JP, Golovato J, Vaske CJ, Sanborn JZ, Nguyen A, Wu W, Goode B, Stevers M, McMullen K, Perez White BE, Collisson EA, Bloomer M, Solomon DA, Benz SC, Cho RJ. PMID: 29760388.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    15. Emergence and Evolution of Mutational Hotspots in Sun-Damaged Skin. J Invest Dermatol. 2018 01; 138(1):16-17. PMID: 29273145.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Questioning the Clinical Utility of Exome Sequencing in Developing Countries. Pediatr Dermatol. 2017 Jan; 34(1):e32-e34. PMID: 27874213.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Election 2016: Voting on Variants. Cancer Discov. 2016 07; 6(7):694-6. PMID: 27371574.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    18. Multiple Hereditary Infundibulocystic Basal Cell Carcinoma Syndrome Associated With a Germline SUFU Mutation. JAMA Dermatol. 2016 Mar; 152(3):323-7. PMID: 26677003.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    19. Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway. Nat Genet. 2015 Oct; 47(10):1194-9. PMID: 26343386.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    20. Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination. Proc Natl Acad Sci U S A. 2015 Sep 01; 112(35):10995-1000. PMID: 26286987.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    21. Erratum to: Modeling precision treatment of breast cancer. Genome Biol. 2015 May 12; 16:95. PMID: 25962591.
      View in: PubMed   Mentions: 4     Fields:    
    22. Transcription restores DNA repair to heterochromatin, determining regional mutation rates in cancer genomes. Cell Rep. 2014 Nov 20; 9(4):1228-34. PMID: 25456125.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    23. No evidence for integrated viral DNA in the genome sequence of cutaneous squamous cell carcinoma. J Invest Dermatol. 2014 Jul; 134(7):2055-2057. PMID: 24480882.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    24. Methods and challenges in timing chromosomal abnormalities within cancer samples. Bioinformatics. 2013 Dec 15; 29(24):3113-20. PMID: 24064421.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    25. Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry. PLoS One. 2013; 8(6):e67306. PMID: 23825651.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    26. Modeling precision treatment of breast cancer. Genome Biol. 2013; 14(10):R110. PMID: 24176112.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansCells
    27. Next-generation diagnostics for genodermatoses. J Invest Dermatol. 2012 Nov 15; 132(E1):E27-8. PMID: 23154629.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    28. Next-Generation Diagnostics for Genodermatoses. J Invest Dermatol. 2012 Nov; 132 Suppl 3:E27-8. PMID: 26875439.
      View in: PubMed   Mentions:    Fields:    
    29. Histology, anatomy, or geography? Exome sequencing begins to delineate somatic mutational differences in esophageal cancer. Cancer Discov. 2012 Oct; 2(10):870-1. PMID: 23071029.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    30. What are we learning from the cancer genome? Nat Rev Clin Oncol. 2012 Nov; 9(11):621-30. PMID: 22965149.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    31. Use of an expanded immunohistochemical panel to distinguish cutaneous Hodgkin lymphoma from histopathologic imitators. J Cutan Pathol. 2012 Jun; 39(6):651-8. PMID: 22324490.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    32. The double-edged sword of Notch signaling in cancer. Semin Cell Dev Biol. 2012 Jun; 23(4):458-64. PMID: 22309843.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    33. Genetics and epigenetics of the skin meet deep sequence. J Invest Dermatol. 2012 Mar; 132(3 Pt 2):923-32. PMID: 22237701.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    34. Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):17761-6. PMID: 22006338.
      View in: PubMed   Mentions: 160     Fields:    Translation:HumansCells
    35. Integrated genomic analyses of ovarian carcinoma. Nature. 2011 Jun 29; 474(7353):609-15. PMID: 21720365.
      View in: PubMed   Mentions: 2459     Fields:    Translation:HumansCells
    36. Temporal dissection of tumorigenesis in primary cancers. Cancer Discov. 2011 Jul; 1(2):137-43. PMID: 21984974.
      View in: PubMed   Mentions: 95     Fields:    Translation:Humans
    37. Rethinking the prosaicism of mosaicism; is it in us? Exp Dermatol. 2010 Dec; 19(12):1037-9. Cho RJ. PMID: 21132868.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    38. Marked papillary dermal edema--an unreliable discriminator between polymorphous light eruption and lupus erythematosus or dermatomyositis. J Cutan Pathol. 2010 Apr; 37(4):416-25. Pincus LB, LeBoit PE, Goddard DS, Cho RJ, McCalmont TH. PMID: 20377671.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    39. A network-based analysis of systemic inflammation in humans. Nature. 2005 Oct 13; 437(7061):1032-7. Calvano SE, Xiao W, Richards DR, Felciano RM, Baker HV, Cho RJ, Chen RO, Brownstein BH, Cobb JP, Tschoeke SK, Miller-Graziano C, Moldawer LL, Mindrinos MN, Davis RW, Tompkins RG, Lowry SF. PMID: 16136080.
      View in: PubMed   Mentions: 631     Fields:    Translation:HumansCellsCTClinical Trials
    40. Computational knowledge integration in biopharmaceutical research. Brief Bioinform. 2003 Sep; 4(3):260-78. Ficenec D, Osborne M, Pradines J, Richards D, Felciano R, Cho RJ, Chen RO, Liefeld T, Owen J, Ruttenberg A, Reich C, Horvath J, Clark T. PMID: 14582520.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    41. Transcriptional regulation and function during the human cell cycle. Nat Genet. 2001 Jan; 27(1):48-54. Cho RJ, Huang M, Campbell MJ, Dong H, Steinmetz L, Sapinoso L, Hampton G, Elledge SJ, Davis RW, Lockhart DJ. PMID: 11137997.
      View in: PubMed   Mentions: 162     Fields:    Translation:HumansCells
    42. A simple procedure for the analysis of single nucleotide polymorphisms facilitates map-based cloning in Arabidopsis. Plant Physiol. 2000 Dec; 124(4):1483-92. Drenkard E, Richter BG, Rozen S, Stutius LM, Angell NA, Mindrinos M, Cho RJ, Oefner PJ, Davis RW, Ausubel FM. PMID: 11115864.
      View in: PubMed   Mentions: 68     Fields:    Translation:Animals
    43. Transcription, genomes, function. Trends Genet. 2000 Sep; 16(9):409-15. Cho RJ, Campbell MJ. PMID: 10973070.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    44. Deriving meaning from genomic information. Biotechnol Genet Eng Rev. 2000; 17:91-107. Cho RJ. PMID: 11255683.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    45. Genome-wide mapping with biallelic markers in Arabidopsis thaliana. Nat Genet. 1999 Oct; 23(2):203-7. Cho RJ, Mindrinos M, Richards DR, Sapolsky RJ, Anderson M, Drenkard E, Dewdney J, Reuber TL, Stammers M, Federspiel N, Theologis A, Yang WH, Hubbell E, Au M, Chung EY, Lashkari D, Lemieux B, Dean C, Lipshutz RJ, Ausubel FM, Davis RW, Oefner PJ. PMID: 10508518.
      View in: PubMed   Mentions: 61     Fields:    Translation:Animals
    46. Candidate regulatory sequence elements for cell cycle-dependent transcription in Saccharomyces cerevisiae. Genome Res. 1999 Aug; 9(8):775-92. Wolfsberg TG, Gabrielian AE, Campbell MJ, Cho RJ, Spouge JL, Landsman D. PMID: 10447512.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    47. Systematic determination of genetic network architecture. Nat Genet. 1999 Jul; 22(3):281-5. Tavazoie S, Hughes JD, Campbell MJ, Cho RJ, Church GM. PMID: 10391217.
      View in: PubMed   Mentions: 599     Fields:    Translation:Animals
    48. A genome-wide transcriptional analysis of the mitotic cell cycle. Mol Cell. 1998 Jul; 2(1):65-73. Cho RJ, Campbell MJ, Winzeler EA, Steinmetz L, Conway A, Wodicka L, Wolfsberg TG, Gabrielian AE, Landsman D, Lockhart DJ, Davis RW. PMID: 9702192.
      View in: PubMed   Mentions: 525     Fields:    Translation:AnimalsCells
    49. Parallel analysis of genetic selections using whole genome oligonucleotide arrays. Proc Natl Acad Sci U S A. 1998 Mar 31; 95(7):3752-7. Cho RJ, Fromont-Racine M, Wodicka L, Feierbach B, Stearns T, Legrain P, Lockhart DJ, Davis RW. PMID: 9520439.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
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