Raymond Cho, MD, PhD

Title(s)Associate Professor, Dermatology
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    Stanford UniversityM.D.2005School of Medicine
    Stanford UniversityPh.D.2003Department of Genetics
    Collapse Awards and Honors
    EBRP/EBMRF2018Epidermolysis Bullosa Research Foundation Award
    Sohana Research Foundation2015Sohana Research Scholar
    Samsung Electronics2013  - 2015SAIT Global Research Outreach Award
    American Skin Association 2012  - 2013Abby S. & Howard P. Milstein Scholar in Melanoma
    Dermatology Foundation2009  - 2012Career Development Award
    American Academy of Dermatology2012Young Investigator Award

    Collapse Overview 
    Collapse Overview
    Dr. Cho investigates the molecular basis of skin disease. He currently develops single-cell molecular fingerprints of unusual skin diseases to identify effective immunomodulatory therapies, in collaboration with the laboratory of Dr. Jeffrey Cheng.

    Dr. Cho's group first reported NOTCH as the most commonly mutated gene in squamous cell cancers of the skin, SUFU loss-of-function as a basis for hereditary infundibulocystic basal cell cancer syndrome, and recurrent mutation of the ZNF750 tumor suppressor in sebaceous carcinoma. His lab also jointly identified APOBEC mutagenesis as the driver for cancer formation in recessive dystrophic epidermolysis bullosa, an inherited blistering disease.

    Receiving both his MD and his PhD in Genetics from the Stanford University School of Medicine, Dr. Cho led the earliest demonstrations of transcriptional profiling, genetic screens, and SNV-based mapping on a whole-genome scale. He subsequently co-founded Ingenuity Systems, a privately funded genetic content and software concern later wholly acquired by Qiagen N.V.

    Dr. Cho has been recognized with the American Academy of Dermatology Young Investigator Award and the Samsung Global Research Outreach Award. He was the Abby S. & Howard P. Milstein Research Scholar in Melanoma and received a Career Development Award from the Dermatology Foundation. He lectures at UCSF and at the Structure and Function of the Skin series in the American Academy of Dermatology's Annual Meeting. In his spare time, Dr. Cho teaches capoeira to golden retrievers.

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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Harirchian P, Lee J, Hilz S, Sedgewick AJ, Perez White BE, Kesling MJ, Mully T, Golovato J, Gray M, Mauro TM, Purdom E, Kim EA, Sbitany H, Bhutani T, Vaske CJ, Benz SC, Cho RJ, Cheng JB. A20 and ABIN1 suppression of a keratinocyte inflammatory program with a shared single cell expression signature in diverse human rashes. J Invest Dermatol. 2018 Dec 10. PMID: 30543901.
      View in: PubMed
    2. Cheng JB, Sedgewick AJ, Finnegan AI, Harirchian P, Lee J, Kwon S, Fassett MS, Golovato J, Gray M, Ghadially R, Liao W, Perez White BE, Mauro TM, Mully T, Kim EA, Sbitany H, Neuhaus IM, Grekin RC, Yu SS, Gray JW, Purdom E, Paus R, Vaske CJ, Benz SC, Song JS, Cho RJ. Transcriptional Programming of Normal and Inflamed Human Epidermis at Single-Cell Resolution. Cell Rep. 2018 Oct 23; 25(4):871-883. PMID: 30355494.
      View in: PubMed
    3. Cho RJ, Alexandrov LB, den Breems NY, Atanasova VS, Farshchian M, Purdom E, Nguyen TN, Coarfa C, Rajapakshe K, Prisco M, Sahu J, Tassone P, Greenawalt EJ, Collisson EA, Wu W, Yao H, Su X, Guttmann-Gruber C, Hofbauer JP, Hashmi R, Fuentes I, Benz SC, Golovato J, Ehli EA, Davis CM, Davies GE, Covington KR, Murrell DF, Salas-Alanis JC, Palisson F, Bruckner AL, Robinson W, Has C, Bruckner-Tuderman L, Titeux M, Jonkman MF, Rashidghamat E, Lwin SM, Mellerio JE, McGrath JA, Bauer JW, Hovnanian A, Tsai KY, South AP. APOBEC mutation drives early-onset squamous cell carcinomas in recessive dystrophic epidermolysis bullosa. Sci Transl Med. 2018 Aug 22; 10(455). PMID: 30135250.
      View in: PubMed
    4. North JP, Golovato J, Vaske CJ, Sanborn JZ, Nguyen A, Wu W, Goode B, Stevers M, McMullen K, Perez White BE, Collisson EA, Bloomer M, Solomon DA, Benz SC, Cho RJ. Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma. Nat Commun. 2018 05 14; 9(1):1894. PMID: 29760388.
      View in: PubMed
    5. Cheng JB, Cho RJ. Emergence and Evolution of Mutational Hotspots in Sun-Damaged Skin. J Invest Dermatol. 2018 Jan; 138(1):16-17. PMID: 29273145.
      View in: PubMed
    6. Fong K, Bailey CV, Tuttle P, Cunningham B, McGrath JA, Cho RJ. Questioning the Clinical Utility of Exome Sequencing in Developing Countries. Pediatr Dermatol. 2017 Jan; 34(1):e32-e34. PMID: 27874213.
      View in: PubMed
    7. Cho RJ, Collisson EA. Election 2016: Voting on Variants. Cancer Discov. 2016 07; 6(7):694-6. PMID: 27371574.
      View in: PubMed
    8. Schulman JM, Oh DH, Sanborn JZ, Pincus L, McCalmont TH, Cho RJ. Multiple Hereditary Infundibulocystic Basal Cell Carcinoma Syndrome Associated With a Germline SUFU Mutation. JAMA Dermatol. 2016 Mar; 152(3):323-7. PMID: 26677003.
      View in: PubMed
    9. Shain AH, Garrido M, Botton T, Talevich E, Yeh I, Sanborn JZ, Chung J, Wang NJ, Kakavand H, Mann GJ, Thompson JF, Wiesner T, Roy R, Olshen AB, Gagnon A, Gray JW, Huh N, Hur JS, Busam KJ, Scolyer RA, Cho RJ, Murali R, Bastian BC. Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway. Nat Genet. 2015 Oct; 47(10):1194-9. PMID: 26343386; PMCID: PMC4589486.
    10. Sanborn JZ, Chung J, Purdom E, Wang NJ, Kakavand H, Wilmott JS, Butler T, Thompson JF, Mann GJ, Haydu LE, Saw RP, Busam KJ, Lo RS, Collisson EA, Hur JS, Spellman PT, Cleaver JE, Gray JW, Huh N, Murali R, Scolyer RA, Bastian BC, Cho RJ. Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination. Proc Natl Acad Sci U S A. 2015 Sep 01; 112(35):10995-1000. PMID: 26286987; PMCID: PMC4568214.
    11. Daemen A, Griffith OL, Heiser LM, Wang NJ, Enache OM, Sanborn Z, Pepin F, Durinck S, Korkola JE, Griffith M, Hur JS, Huh N, Chung J, Cope L, Fackler MJ, Umbricht C, Sukumar S, Seth P, Sukhatme VP, Jakkula LR, Lu Y, Mills GB, Cho RJ, Collisson EA, Van't Veer LJ, Spellman PT, Gray JW. Erratum to: Modeling precision treatment of breast cancer. Genome Biol. 2015 May 12; 16:95. PMID: 25962591.
      View in: PubMed
    12. Zheng CL, Wang NJ, Chung J, Moslehi H, Sanborn JZ, Hur JS, Collisson EA, Vemula SS, Naujokas A, Chiotti KE, Cheng JB, Fassihi H, Blumberg AJ, Bailey CV, Fudem GM, Mihm FG, Cunningham BB, Neuhaus IM, Liao W, Oh DH, Cleaver JE, LeBoit PE, Costello JF, Lehmann AR, Gray JW, Spellman PT, Arron ST, Huh N, Purdom E, Cho RJ. Transcription restores DNA repair to heterochromatin, determining regional mutation rates in cancer genomes. Cell Rep. 2014 Nov 20; 9(4):1228-34. PMID: 25456125; PMCID: PMC4254608.
    13. Dimon MT, Wood HM, Rabbitts PH, Liao W, Cho RJ, Arron ST. No evidence for integrated viral DNA in the genome sequence of cutaneous squamous cell carcinoma. J Invest Dermatol. 2014 Jul; 134(7):2055-2057. PMID: 24480882; PMCID: PMC4057961.
    14. Purdom E, Ho C, Grasso CS, Quist MJ, Cho RJ, Spellman P. Methods and challenges in timing chromosomal abnormalities within cancer samples. Bioinformatics. 2013 Dec 15; 29(24):3113-20. PMID: 24064421; PMCID: PMC3842754.
    15. Kluk MJ, Ashworth T, Wang H, Knoechel B, Mason EF, Morgan EA, Dorfman D, Pinkus G, Weigert O, Hornick JL, Chirieac LR, Hirsch M, Oh DJ, South AP, Leigh IM, Pourreyron C, Cassidy AJ, Deangelo DJ, Weinstock DM, Krop IE, Dillon D, Brock JE, Lazar AJ, Peto M, Cho RJ, Stoeck A, Haines BB, Sathayanrayanan S, Rodig S, Aster JC. Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry. PLoS One. 2013; 8(6):e67306. PMID: 23825651.
      View in: PubMed
    16. Daemen A, Griffith OL, Heiser LM, Wang NJ, Enache OM, Sanborn Z, Pepin F, Durinck S, Korkola JE, Griffith M, Hur JS, Huh N, Chung J, Cope L, Fackler MJ, Umbricht C, Sukumar S, Seth P, Sukhatme VP, Jakkula LR, Lu Y, Mills GB, Cho RJ, Collisson EA, van't Veer LJ, Spellman PT, Gray JW. Modeling precision treatment of breast cancer. Genome Biol. 2013; 14(10):R110. PMID: 24176112; PMCID: PMC3937590.
    17. Cho RJ, Simpson MA, McGrath JA. Next-generation diagnostics for genodermatoses. J Invest Dermatol. 2012 Nov 15; 132(E1):E27-8. PMID: 23154629.
      View in: PubMed
    18. Cho RJ, Simpson MA, McGrath JA. Next-Generation Diagnostics for Genodermatoses. J Invest Dermatol. 2012 Nov; 132 Suppl 3:E27-8. PMID: 26875439.
      View in: PubMed
    19. Collisson EA, Cho RJ. Histology, anatomy, or geography? Exome sequencing begins to delineate somatic mutational differences in esophageal cancer. Cancer Discov. 2012 Oct; 2(10):870-1. PMID: 23071029.
      View in: PubMed
    20. Collisson EA, Cho RJ, Gray JW. What are we learning from the cancer genome? Nat Rev Clin Oncol. 2012 Nov; 9(11):621-30. PMID: 22965149.
      View in: PubMed
    21. Cho RJ, McCalmont TH, Ai WZ, Fox LP, Treseler P, Pincus LB. Use of an expanded immunohistochemical panel to distinguish cutaneous Hodgkin lymphoma from histopathologic imitators. J Cutan Pathol. 2012 Jun; 39(6):651-8. PMID: 22324490.
      View in: PubMed
    22. South AP, Cho RJ, Aster JC. The double-edged sword of Notch signaling in cancer. Semin Cell Dev Biol. 2012 Jun; 23(4):458-64. PMID: 22309843; PMCID: PMC3360804.
    23. Cheng JB, Cho RJ. Genetics and epigenetics of the skin meet deep sequence. J Invest Dermatol. 2012 Mar; 132(3 Pt 2):923-32. PMID: 22237701; PMCID: PMC4099064.
    24. Wang NJ, Sanborn Z, Arnett KL, Bayston LJ, Liao W, Proby CM, Leigh IM, Collisson EA, Gordon PB, Jakkula L, Pennypacker S, Zou Y, Sharma M, North JP, Vemula SS, Mauro TM, Neuhaus IM, Leboit PE, Hur JS, Park K, Huh N, Kwok PY, Arron ST, Massion PP, Bale AE, Haussler D, Cleaver JE, Gray JW, Spellman PT, South AP, Aster JC, Blacklow SC, Cho RJ. Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):17761-6. PMID: 22006338; PMCID: PMC3203814.
    25. Durinck S, Ho C, Wang NJ, Liao W, Jakkula LR, Collisson EA, Pons J, Chan SW, Lam ET, Chu C, Park K, Hong SW, Hur JS, Huh N, Neuhaus IM, Yu SS, Grekin RC, Mauro TM, Cleaver JE, Kwok PY, LeBoit PE, Getz G, Cibulskis K, Aster JC, Huang H, Purdom E, Li J, Bolund L, Arron ST, Gray JW, Spellman PT, Cho RJ. Temporal dissection of tumorigenesis in primary cancers. Cancer Discov. 2011 Jul; 1(2):137-43. PMID: 21984974; PMCID: PMC3187561.
    26. Integrated genomic analyses of ovarian carcinoma. Nature. 2011 Jun 29; 474(7353):609-15. PMID: 21720365; PMCID: PMC3163504.
    27. Cho RJ. Rethinking the prosaicism of mosaicism; is it in us? Exp Dermatol. 2010 Dec; 19(12):1037-9. PMID: 21132868.
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    28. Pincus LB, LeBoit PE, Goddard DS, Cho RJ, McCalmont TH. Marked papillary dermal edema--an unreliable discriminator between polymorphous light eruption and lupus erythematosus or dermatomyositis. J Cutan Pathol. 2010 Apr; 37(4):416-25. PMID: 20377671.
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    29. Calvano SE, Xiao W, Richards DR, Felciano RM, Baker HV, Cho RJ, Chen RO, Brownstein BH, Cobb JP, Tschoeke SK, Miller-Graziano C, Moldawer LL, Mindrinos MN, Davis RW, Tompkins RG, Lowry SF. A network-based analysis of systemic inflammation in humans. Nature. 2005 Oct 13; 437(7061):1032-7. PMID: 16136080.
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    30. Ficenec D, Osborne M, Pradines J, Richards D, Felciano R, Cho RJ, Chen RO, Liefeld T, Owen J, Ruttenberg A, Reich C, Horvath J, Clark T. Computational knowledge integration in biopharmaceutical research. Brief Bioinform. 2003 Sep; 4(3):260-78. PMID: 14582520.
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    31. Cho RJ, Huang M, Campbell MJ, Dong H, Steinmetz L, Sapinoso L, Hampton G, Elledge SJ, Davis RW, Lockhart DJ. Transcriptional regulation and function during the human cell cycle. Nat Genet. 2001 Jan; 27(1):48-54. PMID: 11137997.
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    32. Drenkard E, Richter BG, Rozen S, Stutius LM, Angell NA, Mindrinos M, Cho RJ, Oefner PJ, Davis RW, Ausubel FM. A simple procedure for the analysis of single nucleotide polymorphisms facilitates map-based cloning in Arabidopsis. Plant Physiol. 2000 Dec; 124(4):1483-92. PMID: 11115864; PMCID: PMC1539302.
    33. Cho RJ, Campbell MJ. Transcription, genomes, function. Trends Genet. 2000 Sep; 16(9):409-15. PMID: 10973070.
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    34. Cho RJ. Deriving meaning from genomic information. Biotechnol Genet Eng Rev. 2000; 17:91-107. PMID: 11255683.
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    35. Cho RJ, Mindrinos M, Richards DR, Sapolsky RJ, Anderson M, Drenkard E, Dewdney J, Reuber TL, Stammers M, Federspiel N, Theologis A, Yang WH, Hubbell E, Au M, Chung EY, Lashkari D, Lemieux B, Dean C, Lipshutz RJ, Ausubel FM, Davis RW, Oefner PJ. Genome-wide mapping with biallelic markers in Arabidopsis thaliana. Nat Genet. 1999 Oct; 23(2):203-7. PMID: 10508518.
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    36. Wolfsberg TG, Gabrielian AE, Campbell MJ, Cho RJ, Spouge JL, Landsman D. Candidate regulatory sequence elements for cell cycle-dependent transcription in Saccharomyces cerevisiae. Genome Res. 1999 Aug; 9(8):775-92. PMID: 10447512; PMCID: PMC310804.
    37. Tavazoie S, Hughes JD, Campbell MJ, Cho RJ, Church GM. Systematic determination of genetic network architecture. Nat Genet. 1999 Jul; 22(3):281-5. PMID: 10391217.
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    38. Cho RJ, Campbell MJ, Winzeler EA, Steinmetz L, Conway A, Wodicka L, Wolfsberg TG, Gabrielian AE, Landsman D, Lockhart DJ, Davis RW. A genome-wide transcriptional analysis of the mitotic cell cycle. Mol Cell. 1998 Jul; 2(1):65-73. PMID: 9702192.
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    39. Cho RJ, Fromont-Racine M, Wodicka L, Feierbach B, Stearns T, Legrain P, Lockhart DJ, Davis RW. Parallel analysis of genetic selections using whole genome oligonucleotide arrays. Proc Natl Acad Sci U S A. 1998 Mar 31; 95(7):3752-7. PMID: 9520439; PMCID: PMC19909.