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Suzanne Noble, MD, PhD

Title(s)Associate Professor, Microbiology and Immunology
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoM.D.1997 Medicine
    University of California, San Francisco Postdoctoral StudiesGraduate Division
    University of California, San FranciscoPh.D.1995 Graduate Division (Biochemistry)

    Collapse Research 
    Collapse Research Activities and Funding
    Exploring Paneth Cell Peptide YY (PYY), a unique anti-microbial peptide that maintains fungal commensalism, in the pathogenesis of ileal Crohn?s Disease
    NIH/NIDDK R01DK113788Apr 1, 2017 - Feb 28, 2021
    Role: Co-Principal Investigator
    Treatment and Prevention of Systemic Candidiasis
    NIH/NIAID R33AI127489Dec 9, 2016 - Nov 30, 2021
    Role: Principal Investigator
    Treatment and Prevention of Systemic Candidiasis
    NIH/NIAID R21AI127489Dec 9, 2016 - Nov 30, 2018
    Role: Principal Investigator
    Signals and switches for Candida albicans commensalism
    NIH/NIAID R01AI108992Dec 15, 2013 - Nov 30, 2018
    Role: Principal Investigator
    The Candida albicans commensal program
    NIH/NIAID R21AI099659Feb 15, 2012 - Jan 31, 2014
    Role: Principal Investigator
    A Genetic Approach to Virulence in C. albicans
    NIH/NIAID K08AI062800May 15, 2005 - Apr 30, 2010
    Role: Principal Investigator
    Comprehensive Biology: Exploiting the Yeast Genome
    NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Brimacombe CA, Burke JE, Parsa JY, Catania S, O'Meara TR, Witchley JN, Burrack LS, Madhani HD, Noble SM. A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans. PLoS Biol. 2019 Jun; 17(6):e3000331. PMID: 31226107.
      View in: PubMed
    2. Witchley JN, Penumetcha P, Abon NV, Woolford CA, Mitchell AP, Noble SM. Candida albicans Morphogenesis Programs Control the Balance between Gut Commensalism and Invasive Infection. Cell Host Microbe. 2019 Mar 13; 25(3):432-443.e6. PMID: 30870623.
      View in: PubMed
    3. O'Meara TR, Duah K, Guo CX, Maxson ME, Gaudet RG, Koselny K, Wellington M, Powers ME, MacAlpine J, O'Meara MJ, Veri AO, Grinstein S, Noble SM, Krysan D, Gray-Owen SD, Cowen LE. High-Throughput Screening Identifies Genes Required for Candida albicans Induction of Macrophage Pyroptosis. MBio. 2018 08 21; 9(4). PMID: 30131363.
      View in: PubMed
    4. Tian C, Hromatka BS, Kiefer AK, Eriksson N, Noble SM, Tung JY, Hinds DA. Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections. Nat Commun. 2017 09 19; 8(1):599. PMID: 28928442.
      View in: PubMed
    5. Noble SM, Gianetti BA, Witchley JN. Candida albicans cell-type switching and functional plasticity in the mammalian host. Nat Rev Microbiol. 2017 02; 15(2):96-108. PMID: 27867199.
      View in: PubMed
    6. Phelan VV, Moree WJ, Aguilar J, Cornett DS, Koumoutsi A, Noble SM, Pogliano K, Guerrero CA, Dorrestein PC. Impact of a transposon insertion in phzF2 on the specialized metabolite production and interkingdom interactions of Pseudomonas aeruginosa. J Bacteriol. 2014 May; 196(9):1683-93. PMID: 24532776.
      View in: PubMed
    7. Noble SM. Candida albicans specializations for iron homeostasis: from commensalism to virulence. Curr Opin Microbiol. 2013 Dec; 16(6):708-15. PMID: 24121029.
      View in: PubMed
    8. Pande K, Chen C, Noble SM. Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalism. Nat Genet. 2013 Sep; 45(9):1088-91. PMID: 23892606.
      View in: PubMed
    9. Chen C, Noble SM. Post-transcriptional regulation of the Sef1 transcription factor controls the virulence of Candida albicans in its mammalian host. PLoS Pathog. 2012; 8(11):e1002956. PMID: 23133381.
      View in: PubMed
    10. Chen C, Pande K, French SD, Tuch BB, Noble SM. An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis. Cell Host Microbe. 2011 Aug 18; 10(2):118-35. PMID: 21843869.
      View in: PubMed
    11. Noble SM, French S, Kohn LA, Chen V, Johnson AD. Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity. Nat Genet. 2010 Jul; 42(7):590-8. PMID: 20543849.
      View in: PubMed
    12. Hernday AD, Noble SM, Mitrovich QM, Johnson AD. Genetics and molecular biology in Candida albicans. Methods Enzymol. 2010; 470:737-58. PMID: 20946834.
      View in: PubMed
    13. Homann OR, Dea J, Noble SM, Johnson AD. A phenotypic profile of the Candida albicans regulatory network. PLoS Genet. 2009 Dec; 5(12):e1000783. PMID: 20041210.
      View in: PubMed
    14. Elson SL, Noble SM, Solis NV, Filler SG, Johnson AD. An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth. PLoS Genet. 2009 Sep; 5(9):e1000664. PMID: 19779551.
      View in: PubMed
    15. Liu OW, Chun CD, Chow ED, Chen C, Madhani HD, Noble SM. Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans. Cell. 2008 Oct 03; 135(1):174-88. PMID: 18854164.
      View in: PubMed
    16. Noble SM, Johnson AD. Genetics of Candida albicans, a diploid human fungal pathogen. Annu Rev Genet. 2007; 41:193-211. PMID: 17614788.
      View in: PubMed
    17. Hromatka BS, Noble SM, Johnson AD. Transcriptional response of Candida albicans to nitric oxide and the role of the YHB1 gene in nitrosative stress and virulence. Mol Biol Cell. 2005 Oct; 16(10):4814-26. PMID: 16030247.
      View in: PubMed
    18. Noble SM, Johnson AD. Strains and strategies for large-scale gene deletion studies of the diploid human fungal pathogen Candida albicans. Eukaryot Cell. 2005 Feb; 4(2):298-309. PMID: 15701792.
      View in: PubMed
    19. Chanfreau G, Noble SM, Guthrie C. Essential yeast protein with unexpected similarity to subunits of mammalian cleavage and polyadenylation specificity factor (CPSF). Science. 1996 Nov 29; 274(5292):1511-4. PMID: 8929408.
      View in: PubMed
    20. Noble SM, Guthrie C. Transcriptional pulse-chase analysis reveals a role for a novel snRNP-associated protein in the manufacture of spliceosomal snRNPs. EMBO J. 1996 Aug 15; 15(16):4368-79. PMID: 8861964.
      View in: PubMed
    21. Noble SM, Guthrie C. Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations. Genetics. 1996 May; 143(1):67-80. PMID: 8722763.
      View in: PubMed