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Won-Tak Choi, MD, PhD

TitleAssistant Professor
InstitutionUniversity of California San Francisco
DepartmentPathology
Address505 Parnassus Avenue
San Francisco CA 94117
Phone415-353-9533
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    Collapse Biography 
    Collapse Education and Training
    University of Illinois MD, PhD2009Medicine
    University of California at San FranciscoResidency2010OB/GYN
    Scripps Research Institute Post-Doctoral Research Fellow2011Immunology
    University of Washington Residency2015Pathology
    University of California at San Francisco Fellowship2016Pathology

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Choi W, Wen KW, Rabinovitch PS, Huang D, Mattis AN, Gill RM. DNA Content Analysis of Colorectal Serrated Lesions Detects an Aneuploid Subset of Inflammatory Bowel Disease-Associated Serrated Epithelial Change and Traditional Serrated Adenomas. Histopathology. 2018 May 17. PMID: 29772067.
      View in: PubMed
    2. Wen KW, Rabinovitch PS, Huang D, Mattis AN, Lauwers GY, Choi W. Use of DNA Flow Cytometry in the Diagnosis, Risk Stratification, and Management of Gastric Epithelial Dysplasia. Mod Pathol. 2018; In press.
    3. Choi W, Kakar S. Atypical Hepatocellular Neoplasms: Review of Clinical, Morphologic, Immunohistochemical, Molecular, and Cytogenetic Features. Adv Anat Pathol. 2018 Apr 11. PMID: 29649004.
      View in: PubMed
    4. Choi W, Gill RM. Hepatic Lymphoma Diagnosis. Surg Pathol Clin. 2018 Jun; 11(2):389-402. PMID: 29751882.
      View in: PubMed
    5. Choi W, Brown I, Ushiku T, Yozu M, Setia N, Srivastava A, Johncilla M, Pai RK, Gill RM, Fukayama M, Misdraji J, Lauwers GY. Gastric pyloric gland adenoma: a multicentre clinicopathological study of 67 cases. Histopathology. 2018 May; 72(6):1007-1014. PMID: 29278427.
      View in: PubMed
    6. Fernandez A, Conrad M, Gill RM, Choi W, Kumar V, Behr S. Solitary fibrous tumor in the abdomen and pelvis: A case series with radiological findings and treatment recommendations. Clin Imaging. 2018 Mar - Apr; 48:48-54. PMID: 29028514.
      View in: PubMed
    7. Choi W, Lauwers GY. Patterns of Gastric Injury: Beyond Helicobacter Pylori. Surg Pathol Clin. 2017 Dec; 10(4):801-822. PMID: 29103534.
      View in: PubMed
    8. Zhao L, Westerhoff M, Pai RK, Choi W, Gao ZH, Hart J. Centrilobular ductular reaction correlates with fibrosis stage and fibrosis progression in non-alcoholic steatohepatitis. Mod Pathol. 2018 Jan; 31(1):150-159. PMID: 28862262.
      View in: PubMed
    9. Tsai JH, Rabinovitch PS, Huang D, Small T, Mattis AN, Kakar S, Choi W. Association of Aneuploidy and Flat Dysplasia With Development of High-Grade Dysplasia or Colorectal Cancer in Patients With Inflammatory Bowel Disease. Gastroenterology. 2017 12; 153(6):1492-1495.e4. PMID: 28843957.
      View in: PubMed
    10. Choi W, Tsai JH, Rabinovitch PS, Small T, Huang D, Mattis AN, Kakar S. Diagnosis and risk stratification of Barrett's dysplasia by flow cytometric DNA analysis of paraffin-embedded tissue. Gut. 2017 Jun 22. PMID: 28642331.
      View in: PubMed
    11. Choi W, Kakar S. Immunohistochemistry in the Diagnosis of Hepatocellular Carcinoma. Gastroenterol Clin North Am. 2017 Jun; 46(2):311-325. PMID: 28506367.
      View in: PubMed
    12. Whitcomb E, Choi W, Jerome KR, Cook L, Landis C, Ahn J, Te HS, Esfeh J, Hanouneh IA, Rayhill SC, Gibson W, Plesec T, Koo J, Wang HL, Hart J, Pai RK, Westerhoff M. Biopsy Specimens From Allograft Liver Contain Histologic Features of Hepatitis C Virus Infection After Virus Eradication. Clin Gastroenterol Hepatol. 2017 Aug; 15(8):1279-1285. PMID: 28501538.
      View in: PubMed
    13. Choi W, Jen KY, Wang D, Tavakol M, Roberts JP, Gill RM. Donor Liver Small Droplet Macrovesicular Steatosis Is Associated With Increased Risk for Recipient Allograft Rejection. Am J Surg Pathol. 2017 Mar; 41(3):365-373. PMID: 28059835.
      View in: PubMed
    14. Choi W, Ramachandran R, Kakar S. Immunohistochemical approach for the diagnosis of a liver mass on small biopsy specimens. Hum Pathol. 2017 05; 63:1-13. PMID: 28087475.
      View in: PubMed
    15. Choi W, Chang TT, Gill RM. Gastrointestinal Zygomycosis Masquerading as Acute Appendicitis. Case Rep Gastroenterol. 2016 Jan-Apr; 10(1):81-7. PMID: 27403107; PMCID: PMC4929359.
    16. Choi W, Cherian S, Soma L.Significance of CD10-positive clonal B cell populations identified by flow cytometry in histologically benign gastric biopsies. J Hematop. 2016; 2(9):59-66.
    17. Choi W, Swanson PE, Grieco VS, Wang D, Westerhoff M. The outcomes of "atypical" and "suspicious" bile duct brushings in the identification of pancreaticobiliary tumors: Follow-up analysis of surgical resection specimens. Diagn Cytopathol. 2015 Nov; 43(11):885-91. PMID: 26221777.
      View in: PubMed
    18. Choi W, Rabinovitch PS, Wang D, Westerhoff M. Outcome of "indefinite for dysplasia" in inflammatory bowel disease: correlation with DNA flow cytometry and other risk factors of colorectal cancer. Hum Pathol. 2015 Jul; 46(7):939-47. PMID: 25962315.
      View in: PubMed
    19. Choi W, Emond MJ, Rabinovitch PS, Ahn J, Upton MP, Westerhoff M. "Indefinite for Dysplasia" in Barrett's Esophagus: Inflammation and DNA Content Abnormality are Significant Predictors of Early Detection of Neoplasia. Clin Transl Gastroenterol. 2015 Mar 12; 6:e81. PMID: 25761942; PMCID: PMC4459537.
    20. Choi W, Yang Y, Xu Y, An J. Targeting chemokine receptor CXCR4 for treatment of HIV-1 infection, tumor progression, and metastasis. Curr Top Med Chem. 2014; 14(13):1574-89. PMID: 25159167; PMCID: PMC4372248.
    21. Choi W, Stetsenko GY, Zhang J, Olerud JE, Argenyi ZB, George E. Cutaneous angiosarcoma clinically presenting as progressive solid facial edema in a 43-year-old male. Dermatol Online J. 2013 Nov 15; 19(11):20409. PMID: 24314784.
      View in: PubMed
    22. Choi W, Kumar S, Madani N, Han X, Tian S, Dong CZ, Liu D, Duggineni S, Yuan J, Sodroski JG, Huang Z, An J. A novel synthetic bivalent ligand to probe chemokine receptor CXCR4 dimerization and inhibit HIV-1 entry. Biochemistry. 2012 Sep 11; 51(36):7078-86. PMID: 22897429; PMCID: PMC3476724.
    23. Dong CZ, Tian S, Choi W, Kumar S, Liu D, Xu Y, Han X, Huang Z, An J. Critical role in CXCR4 signaling and internalization of the polypeptide main chain in the amino terminus of SDF-1a probed by novel N-methylated synthetically and modularly modified chemokine analogues. Biochemistry. 2012 Jul 31; 51(30):5951-7. PMID: 22779681; PMCID: PMC3891921.
    24. Choi W, Nedellec R, Coetzer M, Colin P, Lagane B, Offord RE, Hartley O, Mosier DE. CCR5 mutations distinguish N-terminal modifications of RANTES (CCL5) with agonist versus antagonist activity. J Virol. 2012 Sep; 86(18):10218-20. PMID: 22787219; PMCID: PMC3446584.
    25. Choi W, Duggineni S, Xu Y, Huang Z, An J. Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4). J Med Chem. 2012 Feb 09; 55(3):977-94. PMID: 22085380; PMCID: PMC3476736.
    26. Dong CZ, Tian S, Madani N, Choi W, Kumar S, Liu D, Sodroski JG, Huang Z, An J. Role of CXCR4 internalization in the anti-HIV activity of stromal cell-derived factor-1a probed by a novel synthetically and modularly modified-chemokine analog. Exp Biol Med (Maywood). 2011 Dec; 236(12):1413-9. PMID: 22101518; PMCID: PMC3752462.
    27. Choi W, An J. Biology and clinical relevance of chemokines and chemokine receptors CXCR4 and CCR5 in human diseases. Exp Biol Med (Maywood). 2011 Jun 01; 236(6):637-47. PMID: 21565895; PMCID: PMC3932662.
    28. Liu D, Madani N, Li Y, Cao R, Choi W, Kawatkar SP, Lim MY, Kumar S, Dong CZ, Wang J, Russell JD, Lefebure CR, An J, Wilson S, Gao YG, Pallansch LA, Sodroski JG, Huang Z. Crystal structure and structural mechanism of a novel anti-human immunodeficiency virus and D-amino acid-containing chemokine. J Virol. 2007 Oct; 81(20):11489-98. PMID: 17686848; PMCID: PMC2045531.
    29. Choi W, Kumaki Y, Kumar IM, An J, Richman DD, Sodroski JG, Huang Z.Drug Discovery Research: New Frontiers in the Post-Genomic Era. Chapter 12: Basic and Translational Research of Chemokine Ligands and Receptors and Development of Novel Therapeutics. 2007; 300-335.
    30. Choi W, Kaul M, Kumar S, Wang J, Kumar IM, Dong CZ, An J, Lipton SA, Huang Z. Neuronal apoptotic signaling pathways probed and intervened by synthetically and modularly modified (SMM) chemokines. J Biol Chem. 2007 Mar 09; 282(10):7154-63. PMID: 17218311.
      View in: PubMed
    31. Kumar S, Choi W, Dong CZ, Madani N, Tian S, Liu D, Wang Y, Pesavento J, Wang J, Fan X, Yuan J, Fritzsche WR, An J, Sodroski JG, Richman DD, Huang Z. SMM-chemokines: a class of unnatural synthetic molecules as chemical probes of chemokine receptor biology and leads for therapeutic development. Chem Biol. 2006 Jan; 13(1):69-79. PMID: 16426973.
      View in: PubMed
    32. Wang J, Kumar S, Choi W, Dong C, Huang Z. Design and synthesis of novel chemokine analogs derived from vMIP-II. Protein Pept Lett. 2006; 13(5):499-501. PMID: 16800805.
      View in: PubMed
    33. Dong CZ, Kumar S, Choi W, Madani N, Tian S, An J, Sodroski JG, Huang Z. Different stereochemical requirements for CXCR4 binding and signaling functions as revealed by an anti-HIV, D-amino acid-containing SMM-chemokine ligand. J Med Chem. 2005 Dec 15; 48(25):7923-4. PMID: 16335916.
      View in: PubMed
    34. Choi W, Tian S, Dong CZ, Kumar S, Liu D, Madani N, An J, Sodroski JG, Huang Z. Unique ligand binding sites on CXCR4 probed by a chemical biology approach: implications for the design of selective human immunodeficiency virus type 1 inhibitors. J Virol. 2005 Dec; 79(24):15398-404. PMID: 16306611; PMCID: PMC1316031.
    35. Tian S, Choi W, Liu D, Pesavento J, Wang Y, An J, Sodroski JG, Huang Z. Distinct functional sites for human immunodeficiency virus type 1 and stromal cell-derived factor 1alpha on CXCR4 transmembrane helical domains. J Virol. 2005 Oct; 79(20):12667-73. PMID: 16188969; PMCID: PMC1235829.
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