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Won-Tak Choi, MD, PhD

Title(s)Assistant Professor, Pathology
SchoolSchool of Medicine
Phone415-353-9533
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    Collapse Biography 
    Collapse Education and Training
    University of Illinois MD, PhD2009Medicine
    University of California at San FranciscoResidency2010OB/GYN
    Scripps Research Institute Post-Doctoral Research Fellow2011Immunology
    University of Washington Residency2015Pathology
    University of California at San Francisco Fellowship2016Pathology

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. LaFlam TN, Phelps A, Choi WT, Kornblith AE. Meckel Diverticulum Presenting as Abdominal Pain and Subsequent Bowel Perforation. J Emerg Med. 2020 Apr 18. PMID: 32317193.
      View in: PubMed
    2. Wen KW, Rabinovitch PS, Wang D, Mattis AN, Ferrell LD, Choi WT. Utility of DNA flow cytometry in distinguishing between malignant and benign intrahepatic biliary lesions. Virchows Arch. 2020 Apr 15. PMID: 32296928.
      View in: PubMed
    3. Lee H, Rabinovitch PS, Mattis AN, Kakar S, Choi WT. DNA Flow Cytometric Analysis of Paraffin-Embedded Tissue for the Diagnosis of Malignancy in Bile Duct Biopsies. Hum Pathol. 2020 Apr 06. PMID: 32272125.
      View in: PubMed
    4. Choi WT, Yozu M, Miller GC, Shih AR, Kumarasinghe P, Misdraji J, Harpaz N, Lauwers GY. Nonconventional dysplasia in patients with inflammatory bowel disease and colorectal carcinoma: a multicenter clinicopathologic study. Mod Pathol. 2019 Dec 10. PMID: 31822800.
      View in: PubMed
    5. Miller GC, Kumarasinghe MP, Borowsky J, Choi WT, Setia N, Clauditz T, Gidwani R, Sufiyan W, Lauwers GY, Brown IS. Clinicopathological features of pyloric gland adenomas of the duodenum: a multicentre study of 57 cases. Histopathology. 2020 Feb; 76(3):404-410. PMID: 31529725.
      View in: PubMed
    6. Wen KW, Umetsu SE, Goldblum JR, Gill RM, Kim GE, Joseph NM, Rabinovitch PS, Kakar S, Lauwers GY, Choi WT. DNA flow cytometric and interobserver study of crypt cell atypia in inflammatory bowel disease. Histopathology. 2019 Oct; 75(4):578-588. PMID: 31111543.
      View in: PubMed
    7. Hadi R, Shin K, Reder N, Alpert L, Koch L, Choi WT, Swanson PE, Hart J, Westerhoff M. Utility of glutamine synthetase immunohistochemistry in identifying features of regressed cirrhosis. Mod Pathol. 2020 03; 33(3):448-455. PMID: 31391527.
      View in: PubMed
    8. Wen KW, Kim GE, Rabinovitch PS, Wang D, Mattis AN, Choi WT. Diagnosis, risk stratification, and management of ampullary dysplasia by DNA flow cytometric analysis of paraffin-embedded tissue. Mod Pathol. 2019 09; 32(9):1291-1302. PMID: 30976103.
      View in: PubMed
    9. Wen KW, Rabinovitch PS, Wang D, Huang D, Mattis AN, Choi WT. Utility of DNA Flow Cytometric Analysis of Paraffin-embedded Tissue in the Risk Stratification and Management of 'Indefinite for dysplasia' in Patients With Inflammatory Bowel Disease. J Crohns Colitis. 2019 Mar 30; 13(4):472-481. PMID: 30423034.
      View in: PubMed
    10. El-Zimaity H, Choi WT, Lauwers GY, Riddell R. The differential diagnosis of Helicobacter pylori negative gastritis. Virchows Arch. 2018 Nov; 473(5):533-550. PMID: 30255340.
      View in: PubMed
    11. Choi WT, Kakar S. Atypical Hepatocellular Neoplasms: Review of Clinical, Morphologic, Immunohistochemical, Molecular, and Cytogenetic Features. Adv Anat Pathol. 2018 Jul; 25(4):254-262. PMID: 29649004.
      View in: PubMed
    12. Choi WT, Wen KW, Rabinovitch PS, Huang D, Mattis AN, Gill RM. DNA content analysis of colorectal serrated lesions detects an aneuploid subset of inflammatory bowel disease-associated serrated epithelial change and traditional serrated adenomas. Histopathology. 2018 Sep; 73(3):464-472. PMID: 29772067.
      View in: PubMed
    13. Wen KW, Rabinovitch PS, Huang D, Mattis AN, Lauwers GY, Choi WT. Use of DNA flow cytometry in the diagnosis, risk stratification, and management of gastric epithelial dysplasia. Mod Pathol. 2018 10; 31(10):1578-1587. PMID: 29789650.
      View in: PubMed
    14. Choi WT, Gill RM. Hepatic Lymphoma Diagnosis. Surg Pathol Clin. 2018 Jun; 11(2):389-402. PMID: 29751882.
      View in: PubMed
    15. Choi WT, Brown I, Ushiku T, Yozu M, Setia N, Srivastava A, Johncilla M, Pai RK, Gill RM, Fukayama M, Misdraji J, Lauwers GY. Gastric pyloric gland adenoma: a multicentre clinicopathological study of 67 cases. Histopathology. 2018 May; 72(6):1007-1014. PMID: 29278427.
      View in: PubMed
    16. Fernandez A, Conrad M, Gill RM, Choi WT, Kumar V, Behr S. Solitary fibrous tumor in the abdomen and pelvis: A case series with radiological findings and treatment recommendations. Clin Imaging. 2018 Mar - Apr; 48:48-54. PMID: 29028514.
      View in: PubMed
    17. Choi WT, Lauwers GY. Patterns of Gastric Injury: Beyond Helicobacter Pylori. Surg Pathol Clin. 2017 Dec; 10(4):801-822. PMID: 29103534.
      View in: PubMed
    18. Zhao L, Westerhoff M, Pai RK, Choi WT, Gao ZH, Hart J. Centrilobular ductular reaction correlates with fibrosis stage and fibrosis progression in non-alcoholic steatohepatitis. Mod Pathol. 2018 01; 31(1):150-159. PMID: 28862262.
      View in: PubMed
    19. Tsai JH, Rabinovitch PS, Huang D, Small T, Mattis AN, Kakar S, Choi WT. Association of Aneuploidy and Flat Dysplasia With Development of High-Grade Dysplasia or Colorectal Cancer in Patients With Inflammatory Bowel Disease. Gastroenterology. 2017 12; 153(6):1492-1495.e4. PMID: 28843957.
      View in: PubMed
    20. Choi WT, Tsai JH, Rabinovitch PS, Small T, Huang D, Mattis AN, Kakar S. Diagnosis and risk stratification of Barrett's dysplasia by flow cytometric DNA analysis of paraffin-embedded tissue. Gut. 2018 07; 67(7):1229-1238. PMID: 28642331.
      View in: PubMed
    21. Choi WT, Kakar S. Immunohistochemistry in the Diagnosis of Hepatocellular Carcinoma. Gastroenterol Clin North Am. 2017 06; 46(2):311-325. PMID: 28506367.
      View in: PubMed
    22. Whitcomb E, Choi WT, Jerome KR, Cook L, Landis C, Ahn J, Te HS, Esfeh J, Hanouneh IA, Rayhill SC, Gibson W, Plesec T, Koo J, Wang HL, Hart J, Pai RK, Westerhoff M. Biopsy Specimens From Allograft Liver Contain Histologic Features of Hepatitis C Virus Infection After Virus Eradication. Clin Gastroenterol Hepatol. 2017 Aug; 15(8):1279-1285. PMID: 28501538.
      View in: PubMed
    23. Choi WT, Jen KY, Wang D, Tavakol M, Roberts JP, Gill RM. Donor Liver Small Droplet Macrovesicular Steatosis Is Associated With Increased Risk for Recipient Allograft Rejection. Am J Surg Pathol. 2017 Mar; 41(3):365-373. PMID: 28059835.
      View in: PubMed
    24. Choi WT, Ramachandran R, Kakar S. Immunohistochemical approach for the diagnosis of a liver mass on small biopsy specimens. Hum Pathol. 2017 05; 63:1-13. PMID: 28087475.
      View in: PubMed
    25. Choi WT, Chang TT, Gill RM. Gastrointestinal Zygomycosis Masquerading as Acute Appendicitis. Case Rep Gastroenterol. 2016 Jan-Apr; 10(1):81-7. PMID: 27403107.
      View in: PubMed
    26. Choi WT, Cherian S, Soma L.Significance of CD10-positive clonal B cell populations identified by flow cytometry in histologically benign gastric biopsies. J Hematop. 2016; 2(9):59-66.
    27. Choi WT, Swanson PE, Grieco VS, Wang D, Westerhoff M. The outcomes of "atypical" and "suspicious" bile duct brushings in the identification of pancreaticobiliary tumors: Follow-up analysis of surgical resection specimens. Diagn Cytopathol. 2015 Nov; 43(11):885-91. PMID: 26221777.
      View in: PubMed
    28. Choi WT, Rabinovitch PS, Wang D, Westerhoff M. Outcome of "indefinite for dysplasia" in inflammatory bowel disease: correlation with DNA flow cytometry and other risk factors of colorectal cancer. Hum Pathol. 2015 Jul; 46(7):939-47. PMID: 25962315.
      View in: PubMed
    29. Choi WT, Emond MJ, Rabinovitch PS, Ahn J, Upton MP, Westerhoff M. "Indefinite for Dysplasia" in Barrett's Esophagus: Inflammation and DNA Content Abnormality are Significant Predictors of Early Detection of Neoplasia. Clin Transl Gastroenterol. 2015 Mar 12; 6:e81. PMID: 25761942.
      View in: PubMed
    30. Choi WT, Yang Y, Xu Y, An J. Targeting chemokine receptor CXCR4 for treatment of HIV-1 infection, tumor progression, and metastasis. Curr Top Med Chem. 2014; 14(13):1574-89. PMID: 25159167.
      View in: PubMed
    31. Choi WT, Stetsenko GY, Zhang J, Olerud JE, Argenyi ZB, George E. Cutaneous angiosarcoma clinically presenting as progressive solid facial edema in a 43-year-old male. Dermatol Online J. 2013 Nov 15; 19(11):20409. PMID: 24314784.
      View in: PubMed
    32. Choi WT, Kumar S, Madani N, Han X, Tian S, Dong CZ, Liu D, Duggineni S, Yuan J, Sodroski JG, Huang Z, An J. A novel synthetic bivalent ligand to probe chemokine receptor CXCR4 dimerization and inhibit HIV-1 entry. Biochemistry. 2012 Sep 11; 51(36):7078-86. PMID: 22897429.
      View in: PubMed
    33. Dong CZ, Tian S, Choi WT, Kumar S, Liu D, Xu Y, Han X, Huang Z, An J. Critical role in CXCR4 signaling and internalization of the polypeptide main chain in the amino terminus of SDF-1a probed by novel N-methylated synthetically and modularly modified chemokine analogues. Biochemistry. 2012 Jul 31; 51(30):5951-7. PMID: 22779681.
      View in: PubMed
    34. Choi WT, Nedellec R, Coetzer M, Colin P, Lagane B, Offord RE, Hartley O, Mosier DE. CCR5 mutations distinguish N-terminal modifications of RANTES (CCL5) with agonist versus antagonist activity. J Virol. 2012 Sep; 86(18):10218-20. PMID: 22787219.
      View in: PubMed
    35. Choi WT, Duggineni S, Xu Y, Huang Z, An J. Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4). J Med Chem. 2012 Feb 09; 55(3):977-94. PMID: 22085380.
      View in: PubMed
    36. Dong CZ, Tian S, Madani N, Choi WT, Kumar S, Liu D, Sodroski JG, Huang Z, An J. Role of CXCR4 internalization in the anti-HIV activity of stromal cell-derived factor-1a probed by a novel synthetically and modularly modified-chemokine analog. Exp Biol Med (Maywood). 2011 Dec; 236(12):1413-9. PMID: 22101518.
      View in: PubMed
    37. Choi WT, An J. Biology and clinical relevance of chemokines and chemokine receptors CXCR4 and CCR5 in human diseases. Exp Biol Med (Maywood). 2011 Jun 01; 236(6):637-47. PMID: 21565895.
      View in: PubMed
    38. Liu D, Madani N, Li Y, Cao R, Choi WT, Kawatkar SP, Lim MY, Kumar S, Dong CZ, Wang J, Russell JD, Lefebure CR, An J, Wilson S, Gao YG, Pallansch LA, Sodroski JG, Huang Z. Crystal structure and structural mechanism of a novel anti-human immunodeficiency virus and D-amino acid-containing chemokine. J Virol. 2007 Oct; 81(20):11489-98. PMID: 17686848.
      View in: PubMed
    39. Choi WT, Kumaki Y, Kumar IM, An J, Richman DD, Sodroski JG, Huang Z.Drug Discovery Research: New Frontiers in the Post-Genomic Era. Chapter 12: Basic and Translational Research of Chemokine Ligands and Receptors and Development of Novel Therapeutics. 2007; 300-335.
    40. Choi WT, Kaul M, Kumar S, Wang J, Kumar IM, Dong CZ, An J, Lipton SA, Huang Z. Neuronal apoptotic signaling pathways probed and intervened by synthetically and modularly modified (SMM) chemokines. J Biol Chem. 2007 Mar 09; 282(10):7154-63. PMID: 17218311.
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    41. Wang J, Kumar S, Choi WT, Dong C, Huang Z. Design and synthesis of novel chemokine analogs derived from vMIP-II. Protein Pept Lett. 2006; 13(5):499-501. PMID: 16800805.
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    42. Kumar S, Choi WT, Dong CZ, Madani N, Tian S, Liu D, Wang Y, Pesavento J, Wang J, Fan X, Yuan J, Fritzsche WR, An J, Sodroski JG, Richman DD, Huang Z. SMM-chemokines: a class of unnatural synthetic molecules as chemical probes of chemokine receptor biology and leads for therapeutic development. Chem Biol. 2006 Jan; 13(1):69-79. PMID: 16426973.
      View in: PubMed
    43. Dong CZ, Kumar S, Choi WT, Madani N, Tian S, An J, Sodroski JG, Huang Z. Different stereochemical requirements for CXCR4 binding and signaling functions as revealed by an anti-HIV, D-amino acid-containing SMM-chemokine ligand. J Med Chem. 2005 Dec 15; 48(25):7923-4. PMID: 16335916.
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    44. Choi WT, Tian S, Dong CZ, Kumar S, Liu D, Madani N, An J, Sodroski JG, Huang Z. Unique ligand binding sites on CXCR4 probed by a chemical biology approach: implications for the design of selective human immunodeficiency virus type 1 inhibitors. J Virol. 2005 Dec; 79(24):15398-404. PMID: 16306611.
      View in: PubMed
    45. Tian S, Choi WT, Liu D, Pesavento J, Wang Y, An J, Sodroski JG, Huang Z. Distinct functional sites for human immunodeficiency virus type 1 and stromal cell-derived factor 1alpha on CXCR4 transmembrane helical domains. J Virol. 2005 Oct; 79(20):12667-73. PMID: 16188969.
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