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Nancy Joseph, MD, PhD

TitleAssistant Professor
InstitutionUniversity of California San Francisco
DepartmentPathology
Address505 Parnassus Avenue
San Francisco CA 94117
Phone415-502-6359
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    Collapse Research 
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    Neural stem cells in DRG and neurofibromatosis type 1
    NIH/NINDS F30NS049761Jul 1, 2004 - Jun 30, 2007
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Phillips JJ, Gong H, Chen K, Joseph N, van Ziffle J, Bastian BC, Grenert JP, Kline CN, Mueller S, Banerjee A, Nicolaides T, Gupta N, Berger MS, Lee HS, Pekmezci M, Tihan T, Bollen AW, Perry A, Shieh JTC, Solomon DA. The genetic landscape of anaplastic pleomorphic xanthoastrocytoma. Brain Pathol. 2018 Jul 27. PMID: 30051528.
      View in: PubMed
    2. Zeng H, Jorapur A, Shain AH, Lang UE, Torres R, Zhang Y, McNeal AS, Botton T, Lin J, Donne M, Bastian IN, Yu R, North JP, Pincus L, Ruben BS, Joseph N, Yeh I, Bastian BC, Judson RL. Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation. Cancer Cell. 2018 Jul 09; 34(1):56-68.e9. PMID: 29990501.
      View in: PubMed
    3. Shain AH, Joseph N, Yu R, Benhamida J, Liu S, Prow T, Ruben B, North J, Pincus L, Yeh I, Judson R, Bastian BC. Genomic and Transcriptomic Analysis Reveals Incremental Disruption of Key Signaling Pathways during Melanoma Evolution. Cancer Cell. 2018 Jul 09; 34(1):45-55.e4. PMID: 29990500.
      View in: PubMed
    4. Joseph N, Brunt EM, Marginean C, Nalbantoglu I, Snover DC, Thung SN, Yeh MM, Umetsu SE, Ferrell LD, Gill RM. Frequent GNAQ and GNA14 Mutations in Hepatic Small Vessel Neoplasm. Am J Surg Pathol. 2018 Jul 03. PMID: 29975248.
      View in: PubMed
    5. Wen KW, Grenert JP, Joseph N, Shafizadeh N, Huang A, Hosseini M, Kakar S. Genomic Profile of Appendiceal Goblet Cell Carcinoid Is Distinct Compared to Appendiceal Neuroendocrine Tumor and Conventional Adenocarcinoma. Hum Pathol. 2018 Apr 07. PMID: 29634977.
      View in: PubMed
    6. Bean GR, Joseph N, Folpe AL, Horvai AE, Umetsu SE. Recurrent GNA14 mutations in anastomosing hemangiomas. Histopathology. 2018 Mar 25. PMID: 29574926.
      View in: PubMed
    7. Yan Z, Grenert JP, Joseph N, Xu C, Chen X, Shafizadeh N, Kakar S. Hepatic Angiomyolipoma: Mutation Analysis and Immunohistochemical Pitfalls in Diagnosis. Histopathology. 2018 Mar 07. PMID: 29512829.
      View in: PubMed
    8. Joseph N, Pineda C, Rabban JT. DNA Genotyping of Nonmolar Donor Egg Pregnancies With Abnormal Villous Morphology: Allele Zygosity Patterns Prevent Misinterpretation as Complete Hydatidiform Mole. Int J Gynecol Pathol. 2018 Mar; 37(2):191-197. PMID: 28463912.
      View in: PubMed
    9. Goode B, Mondal G, Hyun M, Ruiz DG, Lin YH, Van Ziffle J, Joseph N, Onodera C, Talevich E, Grenert JP, Hewedi IH, Snuderl M, Brat DJ, Kleinschmidt-DeMasters BK, Rodriguez FJ, Louis DN, Yong WH, Lopes MB, Rosenblum MK, Butowski N, Tihan T, Bollen AW, Phillips JJ, Wiita AP, Yeh I, Jacobson MP, Bastian BC, Perry A, Solomon DA. A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle. Nat Commun. 2018 02 23; 9(1):810. PMID: 29476136.
      View in: PubMed
    10. Goode B, Joseph N, Stevers M, Van Ziffle J, Onodera C, Talevich E, Grenert JP, Yeh I, Bastian BC, Phillips JJ, Garg K, Rabban JT, Zaloudek C, Solomon DA. Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation. Mod Pathol. 2018 Apr; 31(4):660-673. PMID: 29148537.
      View in: PubMed
    11. Nolan A, Joseph N, Sangoi AR, Rabban J, Zaloudek C, Garg K. FOXL2 Mutation Status in Granulosa Theca Cell Tumors of the Ovary. Int J Gynecol Pathol. 2017 Nov; 36(6):568-574. PMID: 28319575.
      View in: PubMed
    12. Cohen JN, Joseph N, North JP, Onodera C, Zembowicz A, LeBoit PE. Genomic Analysis of Pigmented Epithelioid Melanocytomas Reveals Recurrent Alterations in PRKAR1A, and PRKCA Genes. Am J Surg Pathol. 2017 Oct; 41(10):1333-1346. PMID: 28796000.
      View in: PubMed
    13. Chapel DB, Joseph N, Krausz T, Lastra RR. An Ovarian Adenocarcinoma With Combined Low-grade Serous and Mesonephric Morphologies Suggests a Müllerian Origin for Some Mesonephric Carcinomas. Int J Gynecol Pathol. 2017 Aug 31. PMID: 28863071.
      View in: PubMed
    14. Krings G, Joseph N, Bean GR, Solomon D, Onodera C, Talevich E, Yeh I, Grenert JP, Hosfield E, Crawford ED, Jordan RC, van Zante A, Zaloudek C, Shin SJ, Chen YY. Genomic profiling of breast secretory carcinomas reveals distinct genetics from other breast cancers and similarity to mammary analog secretory carcinomas. Mod Pathol. 2017 Aug; 30(8):1086-1099. PMID: 28548128.
      View in: PubMed
    15. Kline CN, Joseph N, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein S, Torkildson J, Samuel D, Bloomer M, Campomanes AGA, Banerjee A, Butowski N, Raffel C, Tihan T, Bollen AW, Phillips JJ, Korn WM, Yeh I, Bastian BC, Gupta N, Mueller S, Perry A, Nicolaides T, Solomon DA. Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy. Neuro Oncol. 2017 05 01; 19(5):699-709. PMID: 28453743.
      View in: PubMed
    16. Bean GR, Joseph N, Gill RM, Folpe AL, Horvai AE, Umetsu SE. Recurrent GNAQ mutations in anastomosing hemangiomas. Mod Pathol. 2017 May; 30(5):722-727. PMID: 28084343.
      View in: PubMed
    17. Joseph N, Chen YY, Nasr A, Yeh I, Talevich E, Onodera C, Bastian BC, Rabban JT, Garg K, Zaloudek C, Solomon DA. Genomic profiling of malignant peritoneal mesothelioma reveals recurrent alterations in epigenetic regulatory genes BAP1, SETD2, and DDX3X. Mod Pathol. 2017 Feb; 30(2):246-254. PMID: 27813512.
      View in: PubMed
    18. Phillips JJ, Gong H, Chen K, Joseph N, van Ziffle J, Jin LW, Bastian BC, Bollen AW, Perry A, Nicolaides T, Solomon DA, Shieh JT. Activating NRF1-BRAF and ATG7-RAF1 fusions in anaplastic pleomorphic xanthoastrocytoma without BRAF p.V600E mutation. Acta Neuropathol. 2016 11; 132(5):757-760. PMID: 27624885.
      View in: PubMed
    19. Buelow B, Cohen J, Nagymanyoki Z, Frizzell N, Joseph N, McCalmont T, Garg K. Immunohistochemistry for 2-Succinocysteine (2SC) and Fumarate Hydratase (FH) in Cutaneous Leiomyomas May Aid in Identification of Patients With HLRCC (Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome). Am J Surg Pathol. 2016 Jul; 40(7):982-8. PMID: 26945337.
      View in: PubMed
    20. Liu SY, Joseph N, Ravindranathan A, Stohr BA, Greenland NY, Vohra P, Hosfield E, Yeh I, Talevich E, Onodera C, Van Ziffle JA, Grenert JP, Bastian BC, Chen YY, Krings G. Genomic profiling of malignant phyllodes tumors reveals aberrations in FGFR1 and PI-3 kinase/RAS signaling pathways and provides insights into intratumoral heterogeneity. Mod Pathol. 2016 09; 29(9):1012-27. PMID: 27255162.
      View in: PubMed
    21. Ferris SP, Goode B, Joseph N, Kline CN, Samuel D, Gupta N, Bollen A, Perry A, Mueller S, Solomon DA. IDH1 mutation can be present in diffuse astrocytomas and giant cell glioblastomas of young children under 10 years of age. Acta Neuropathol. 2016 07; 132(1):153-5. PMID: 27161253; PMCID: PMC4915961 [Available on 07/01/17].
    22. Gill RM, Buelow B, Mather C, Joseph N, Alves V, Brunt EM, Liu TC, Makhlouf H, Marginean C, Nalbantoglu I, Sempoux C, Snover DC, Thung SN, Yeh MM, Ferrell LD. Hepatic small vessel neoplasm, a rare infiltrative vascular neoplasm of uncertain malignant potential. Hum Pathol. 2016 08; 54:143-51. PMID: 27090685.
      View in: PubMed
    23. Schwetye KE, Joseph N, Al-Kateb H, Rich KM, Schmidt RE, Perry A, Gutmann DH, Dahiya S. Gliosarcomas lack BRAFV600E mutation, but a subset exhibit ß-catenin nuclear localization. Neuropathology. 2016 Oct; 36(5):448-455. PMID: 26932501.
      View in: PubMed
    24. Kline CN, Joseph N, Grenert JP, van Ziffle J, Yeh I, Bastian BC, Mueller S, Solomon DA. Inactivating MUTYH germline mutations in pediatric patients with high-grade midline gliomas. Neuro Oncol. 2016 05; 18(5):752-3. PMID: 26902849; PMCID: PMC4827050 [Available on 05/01/17].
    25. Joseph N, Solomon DA, Frizzell N, Rabban JT, Zaloudek C, Garg K. Morphology and Immunohistochemistry for 2SC and FH Aid in Detection of Fumarate Hydratase Gene Aberrations in Uterine Leiomyomas From Young Patients. Am J Surg Pathol. 2015 Nov; 39(11):1529-39. PMID: 26457356.
      View in: PubMed
    26. Ko AH, Bekaii-Saab T, Van Ziffle J, Mirzoeva OM, Joseph N, Talasaz A, Kuhn P, Tempero MA, Collisson EA, Kelley RK, Venook AP, Dito E, Ong A, Ziyeh S, Courtin R, Linetskaya R, Tahiri S, Korn WM. A Multicenter, Open-Label Phase II Clinical Trial of Combined MEK plus EGFR Inhibition for Chemotherapy-Refractory Advanced Pancreatic Adenocarcinoma. Clin Cancer Res. 2016 Jan 01; 22(1):61-8. PMID: 26251290; PMCID: PMC4703532 [Available on 01/01/17].
    27. Ali S, Joseph N, Perry A, Barajas RF, Cha S. Apparent diffusion coefficient in glioblastoma with PNET-like components, a GBM variant. J Neurooncol. 2014 Sep; 119(2):353-60. PMID: 24893732.
      View in: PubMed
    28. Joseph N, Ferrell LD, Jain D, Torbenson MS, Wu TT, Yeh MM, Kakar S. Diagnostic utility and limitations of glutamine synthetase and serum amyloid-associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma. Mod Pathol. 2014 Jan; 27(1):62-72. PMID: 23807780.
      View in: PubMed
    29. Joseph N, Phillips J, Dahiya S, M Felicella M, Tihan T, Brat DJ, Perry A. Diagnostic implications of IDH1-R132H and OLIG2 expression patterns in rare and challenging glioblastoma variants. Mod Pathol. 2013 Mar; 26(3):315-26. PMID: 23041832.
      View in: PubMed
    30. Joseph N, He S, Quintana E, Kim YG, Núñez G, Morrison SJ. Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut. J Clin Invest. 2011 Sep; 121(9):3398-411. PMID: 21865643; PMCID: PMC3163971.
    31. Lee JY, Nakada D, Yilmaz OH, Tothova Z, Joseph N, Lim MS, Gilliland DG, Morrison SJ. mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion. Cell Stem Cell. 2010 Nov 05; 7(5):593-605. PMID: 21040901; PMCID: PMC2995996.
    32. Joseph N, Mosher JT, Buchstaller J, Snider P, McKeever PE, Lim M, Conway SJ, Parada LF, Zhu Y, Morrison SJ. The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells. Cancer Cell. 2008 Feb; 13(2):129-40. PMID: 18242513; PMCID: PMC2566828.
    33. Mosher JT, Yeager KJ, Kruger GM, Joseph N, Hutchin ME, Dlugosz AA, Morrison SJ. Intrinsic differences among spatially distinct neural crest stem cells in terms of migratory properties, fate determination, and ability to colonize the enteric nervous system. Dev Biol. 2007 Mar 01; 303(1):1-15. PMID: 17113577; PMCID: PMC1910607.
    34. Molofsky AV, Slutsky SG, Joseph N, He S, Pardal R, Krishnamurthy J, Sharpless NE, Morrison SJ. Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature. 2006 Sep 28; 443(7110):448-52. PMID: 16957738; PMCID: PMC2586960.
    35. Joseph N, Morrison SJ. Toward an understanding of the physiological function of Mammalian stem cells. Dev Cell. 2005 Aug; 9(2):173-83. PMID: 16054025.
      View in: PubMed
    36. Joseph N, Mukouyama YS, Mosher JT, Jaegle M, Crone SA, Dormand EL, Lee KF, Meijer D, Anderson DJ, Morrison SJ. Neural crest stem cells undergo multilineage differentiation in developing peripheral nerves to generate endoneurial fibroblasts in addition to Schwann cells. Development. 2004 Nov; 131(22):5599-612. PMID: 15496445; PMCID: PMC2638001.
    37. Bixby S, Kruger GM, Mosher JT, Joseph N, Morrison SJ. Cell-intrinsic differences between stem cells from different regions of the peripheral nervous system regulate the generation of neural diversity. Neuron. 2002 Aug 15; 35(4):643-56. PMID: 12194865.
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    38. Kruger GM, Mosher JT, Bixby S, Joseph N, Iwashita T, Morrison SJ. Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness. Neuron. 2002 Aug 15; 35(4):657-69. PMID: 12194866; PMCID: PMC2728576.
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