Susanna Rosi, PhD

Title(s)Professor, Physical Therapy
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Awards and Honors
    NIH,NIA2017  - 2019Sponsor, Individual Postdoc NRSA F32 (Karen Krukowski, Fellow)
    UCSF Weill Institute for Neuroscience2016  - 2019Weill Innovation Award
    Marcus Program on Precision Medicine2016  - 2017Marcus Program in Precision Medicine Innovation seeding bold ideas.
    California Institute for Quantitative Bioscience2015  - 2017Bridging the Gap Award
    National Aeronautic Space Agency2014  - 2019NASA Research Award
    NIH-NINDS2014  - 2016Sponsor, Individual Postdoc NRSA F32 (Josh Morganti, Fellow)
    Alzheimer Association2008  - 2010New Investigator Research Award, Alzheimer’s Association
    Alzheimer Association2011  - 2015 Initiated Investigator Research Award, Alzheimer’s Association.
    City of Arezzo, Italy2007Tuscany Special Award “Young Talents and Magnificent Excellences”, Arezzo, Italy
    Castiglion Fiorentino, Arezzo, Italy2006Special Award for Research and Career “Vel l’Etrusco”,

    Collapse Overview 
    Collapse Overview
    Director of Neurocognitive Research
    Brain and Spinal Injury Center
    Weill Institute for Neuroscience
    Kavli Institute of Fundamental Neuroscience
    Zuckerberg San Francisco General Hospital

    Collapse Research 
    Collapse Research Activities and Funding
    Astroglial EAAT2 Changes in Live TBI Brain Determined by PET Imaging
    NIH/NINDS R41NS105309Sep 1, 2018 - Aug 31, 2019
    Role: Co-Principal Investigator
    Translational Outcomes Project: Visualizing Syndromic Information and Outcomes for Neurotrauma (TOP-VISION)
    NIH/NINDS UG3NS106899Apr 1, 2018 - Mar 31, 2020
    Role: Co-Principal Investigator
    Aging exacerbates trauma-induced immune pathways and neuronal dysfunction
    NIH/NIA R01AG056770Sep 1, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Therapeutic Irradiation and Brain Functions
    NIH/NCI R01CA213441Dec 9, 2016 - Nov 30, 2021
    Role: Principal Investigator
    In vivo metabolic imaging of neuroinflammation after TBI
    NIH/NINDS R21NS096718Feb 1, 2016 - Jan 31, 2018
    Role: Principal Investigator
    Contribution of infiltrating macrophages on synaptic function after TBI
    NIH/NINDS R21NS087458Sep 1, 2014 - Aug 31, 2016
    Role: Principal Investigator
    Effects of traumatic brain injury on hippocampal network activity: age difference
    NIH/NIA R21AG042016Jun 15, 2013 - May 31, 2015
    Role: Principal Investigator
    Brain Irradiation Affects Neuronal Function
    NIH/NCI R01CA133216Jun 1, 2009 - Apr 30, 2014
    Role: Principal Investigator

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    Collapse Featured Publications
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    Collapse In The News
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Krukowski K, Chou A, Feng X, Tiret B, Paladini MS, Riparip LK, Chaumeil MM, Lemere C, Rosi S. Traumatic Brain Injury in Aged Mice Induces Chronic Microglia Activation, Synapse Loss, and Complement-Dependent Memory Deficits. Int J Mol Sci. 2018 Nov 26; 19(12). PMID: 30486287.
      View in: PubMed
    2. Feng X, Liu S, Chen D, Rosi S, Gupta N. Rescue of cognitive function following fractionated brain irradiation in a novel preclinical glioma model. Elife. 2018 11 13; 7. PMID: 30421720.
      View in: PubMed
    3. Rosi S. The final frontier: Transient microglia reduction after cosmic radiation exposure mitigates cognitive impairments and modulates phagocytic activity. Brain Circ. 2018 Jul-Sep; 4(3):109-113. PMID: 30450416.
      View in: PubMed
    4. Vonder Haar C, Ferland JN, Kaur S, Riparip LK, Rosi S, Winstanley CA. Cocaine self-administration is increased after frontal traumatic brain injury and associated with neuroinflammation. Eur J Neurosci. 2018 Aug 17. PMID: 30118561.
      View in: PubMed
    5. Krukowski K, Grue K, Frias ES, Pietrykowski J, Jones T, Nelson G, Rosi S. Female mice are protected from space radiation-induced maladaptive responses. Brain Behav Immun. 2018 Nov; 74:106-120. PMID: 30107198.
      View in: PubMed
    6. Krukowski K, Feng X, Paladini MS, Chou A, Sacramento K, Grue K, Riparip LK, Jones T, Campbell-Beachler M, Nelson G, Rosi S. Author Correction: Temporary microglia-depletion after cosmic radiation modifies phagocytic activity and prevents cognitive deficits. Sci Rep. 2018 Jul 03; 8(1):10297. PMID: 29967490.
      View in: PubMed
    7. Nolan A, Hennessy E, Krukowski K, Guglielmetti C, Chaumeil MM, Sohal VS, Rosi S. Repeated Mild Head Injury Leads to Wide-Ranging Deficits in Higher-Order Cognitive Functions Associated with the Prefrontal Cortex. J Neurotrauma. 2018 Oct 15; 35(20):2425-2434. PMID: 29732949.
      View in: PubMed
    8. Chou A, Krukowski K, Morganti JM, Riparip LK, Rosi S. Persistent Infiltration and Impaired Response of Peripherally-Derived Monocytes after Traumatic Brain Injury in the Aged Brain. Int J Mol Sci. 2018 May 30; 19(6). PMID: 29848996.
      View in: PubMed
    9. Krukowski K, Jones T, Campbell-Beachler M, Nelson G, Rosi S. Peripheral T Cells as a Biomarker for Oxygen-Ion-Radiation-Induced Social Impairments. Radiat Res. 2018 08; 190(2):186-193. PMID: 29809107.
      View in: PubMed
    10. Krukowski K, Feng X, Paladini MS, Chou A, Sacramento K, Grue K, Riparip LK, Jones T, Campbell-Beachler M, Nelson G, Rosi S. Temporary microglia-depletion after cosmic radiation modifies phagocytic activity and prevents cognitive deficits. Sci Rep. 2018 May 18; 8(1):7857. PMID: 29777152.
      View in: PubMed
    11. Guglielmetti C, Chou A, Krukowski K, Najac C, Feng X, Riparip LK, Rosi S, Chaumeil MM. In vivo metabolic imaging of Traumatic Brain Injury. Sci Rep. 2017 Dec 13; 7(1):17525. PMID: 29235509.
      View in: PubMed
    12. Rosi S. Colony stimulating factor-1 receptor as a treatment for cognitive deficits postfractionated whole-brain irradiation. Brain Circ. 2017 Jul-Sep; 3(3):180-182. PMID: 30276322.
      View in: PubMed
    13. Impey S, Jopson T, Pelz C, Tafessu A, Fareh F, Zuloaga D, Marzulla T, Riparip LK, Stewart B, Rosi S, Turker MS, Raber J. Bi-directional and shared epigenomic signatures following proton and 56Fe irradiation. Sci Rep. 2017 Aug 31; 7(1):10227. PMID: 28860502.
      View in: PubMed
    14. Chou A, Krukowski K, Jopson T, Zhu PJ, Costa-Mattioli M, Walter P, Rosi S. Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury. Proc Natl Acad Sci U S A. 2017 08 01; 114(31):E6420-E6426. PMID: 28696288.
      View in: PubMed
    15. Feng X, Krukowski K, Jopson T, Rosi S. Delayed-matching-to-place Task in a Dry Maze to Measure Spatial Working Memory in Mice. Bio Protoc. 2017 Jul 05; 7(13). PMID: 28944261.
      View in: PubMed
    16. Vonder Haar C, Martens KM, Riparip LK, Rosi S, Wellington CL, Winstanley CA. Frontal Traumatic Brain Injury Increases Impulsive Decision Making in Rats: A Potential Role for the Inflammatory Cytokine Interleukin-12. J Neurotrauma. 2017 Oct 01; 34(19):2790-2800. PMID: 28376700.
      View in: PubMed
    17. Klein RS, Voskuhl R, Segal BM, Dittel BN, Lane TE, Bethea JR, Carson MJ, Colton C, Rosi S, Anderson A, Piccio L, Goverman JM, Benveniste EN, Brown MA, Tiwari-Woodruff SK, Harris TH, Cross AH. Speaking out about gender imbalance in invited speakers improves diversity. Nat Immunol. 2017 04 18; 18(5):475-478. PMID: 28418385.
      View in: PubMed
    18. Feng X, Rosi S. Targeting colony stimulating factor 1 receptor to prevent cognitive deficits induced by fractionated whole-brain irradiation. Neural Regen Res. 2017 Mar; 12(3):399-400. PMID: 28469650.
      View in: PubMed
    19. Impey S, Jopson T, Pelz C, Tafessu A, Fareh F, Zuloaga D, Marzulla T, Riparip LK, Stewart B, Rosi S, Turker MS, Raber J. Short- and long-term effects of 56Fe irradiation on cognition and hippocampal DNA methylation and gene expression. BMC Genomics. 2016 10 24; 17(1):825. PMID: 27776477.
      View in: PubMed
    20. Rosi S. A polarizing view on posttraumatic brain injury inflammatory response. Brain Circ. 2016 Jul-Sep; 2(3):126-128. PMID: 30276287.
      View in: PubMed
    21. Vonder Haar C, Lam FC, Adams WK, Riparip LK, Kaur S, Muthukrishna M, Rosi S, Winstanley CA. Frontal Traumatic Brain Injury in Rats Causes Long-Lasting Impairments in Impulse Control That Are Differentially Sensitive to Pharmacotherapeutics and Associated with Chronic Neuroinflammation. ACS Chem Neurosci. 2016 11 16; 7(11):1531-1542. PMID: 27525447.
      View in: PubMed
    22. Lee S, Mattingly A, Lin A, Sacramento J, Mannent L, Castel MN, Canolle B, Delbary-Gossart S, Ferzaz B, Morganti JM, Rosi S, Ferguson AR, Manley GT, Bresnahan JC, Beattie MS. A novel antagonist of p75NTR reduces peripheral expansion and CNS trafficking of pro-inflammatory monocytes and spares function after traumatic brain injury. J Neuroinflammation. 2016 Apr 22; 13(1):88. PMID: 27102880; PMCID: PMC4840857.
    23. Morganti JM, Riparip LK, Chou A, Liu S, Gupta N, Rosi S. Age exacerbates the CCR2/5-mediated neuroinflammatory response to traumatic brain injury. J Neuroinflammation. 2016 Apr 18; 13(1):80. PMID: 27090212; PMCID: PMC4835854.
    24. Chou A, Morganti JM, Rosi S. Frontal Lobe Contusion in Mice Chronically Impairs Prefrontal-Dependent Behavior. PLoS One. 2016; 11(3):e0151418. PMID: 26964036; PMCID: PMC4786257.
    25. Morganti JM, Riparip LK, Rosi S. Call Off the Dog(ma): M1/M2 Polarization Is Concurrent following Traumatic Brain Injury. PLoS One. 2016; 11(1):e0148001. PMID: 26808663; PMCID: PMC4726527.
    26. Raber J, Allen AR, Sharma S, Allen B, Rosi S, Olsen RH, Davis MJ, Eiwaz M, Fike JR, Nelson GA. Effects of Proton and Combined Proton and (56)Fe Radiation on the Hippocampus. Radiat Res. 2016 Jan; 185(1):20-30. PMID: 26720797.
      View in: PubMed
    27. Morganti JM, Jopson TD, Liu S, Riparip LK, Guandique CK, Gupta N, Ferguson AR, Rosi S. CCR2 antagonism alters brain macrophage polarization and ameliorates cognitive dysfunction induced by traumatic brain injury. J Neurosci. 2015 Jan 14; 35(2):748-60. PMID: 25589768; PMCID: PMC4293420.
    28. Parihar VK, Allen BD, Tran KK, Chmielewski NN, Craver BM, Martirosian V, Morganti JM, Rosi S, Vlkolinsky R, Acharya MM, Nelson GA, Allen AR, Limoli CL. Targeted overexpression of mitochondrial catalase prevents radiation-induced cognitive dysfunction. Antioxid Redox Signal. 2015 Jan 01; 22(1):78-91. PMID: 24949841; PMCID: PMC4270160.
    29. Allen AR, Eilertson K, Sharma S, Baure J, Allen B, Leu D, Rosi S, Raber J, Huang TT, Fike JR. Delayed administration of alpha-difluoromethylornithine prevents hippocampus-dependent cognitive impairment after single and combined injury in mice. Radiat Res. 2014 Nov; 182(5):489-98. PMID: 25375198; PMCID: PMC4282164.
    30. Acharya MM, Rosi S, Jopson T, Limoli CL. Human neural stem cell transplantation provides long-term restoration of neuronal plasticity in the irradiated hippocampus. Cell Transplant. 2015; 24(4):691-702. PMID: 25289634.
      View in: PubMed
    31. Morganti JM, Jopson TD, Liu S, Gupta N, Rosi S. Cranial irradiation alters the brain's microenvironment and permits CCR2+ macrophage infiltration. PLoS One. 2014; 9(4):e93650. PMID: 24695541; PMCID: PMC3973545.
    32. Raber J, Rudobeck E, Campbell-Beachler M, Allen AR, Allen B, Rosi S, Nelson GA, Ramachandran S, Turner J, Fike JR, Vlkolinsky R. (28)Silicon radiation-induced enhancement of synaptic plasticity in the hippocampus of naïve and cognitively tested mice. Radiat Res. 2014 Apr; 181(4):362-8. PMID: 24673255.
      View in: PubMed
    33. Allen AR, Eilertson K, Chakraborti A, Sharma S, Baure J, Habdank-Kolaczkowski J, Allen B, Rosi S, Raber J, Fike JR. Radiation exposure prior to traumatic brain injury induces responses that differ as a function of animal age. Int J Radiat Biol. 2014 Mar; 90(3):214-23. PMID: 24164494; PMCID: PMC3971762.
    34. Belarbi K, Rosi S. Modulation of adult-born neurons in the inflamed hippocampus. Front Cell Neurosci. 2013 Sep 06; 7:145. PMID: 24046730; PMCID: PMC3764370.
    35. Allen AR, Eilertson K, Sharma S, Schneider D, Baure J, Allen B, Rosi S, Raber J, Fike JR. Effects of radiation combined injury on hippocampal function are modulated in mice deficient in chemokine receptor 2 (CCR2). Radiat Res. 2013 Jul; 180(1):78-88. PMID: 23772926; PMCID: PMC4282166.
    36. Raber J, Allen AR, Rosi S, Sharma S, Dayger C, Davis MJ, Fike JR. Effects of (56)Fe radiation on hippocampal function in mice deficient in chemokine receptor 2 (CCR2). Behav Brain Res. 2013 Jun 01; 246:69-75. PMID: 23500678.
      View in: PubMed
    37. Raber J, Allen AR, Rosi S, Sharma S, Dayger C, Davis MJ, Fike JR. Effects of whole body (56)Fe radiation on contextual freezing and Arc-positive cells in the dentate gyrus. Behav Brain Res. 2013 Jun 01; 246:162-7. PMID: 23454674.
      View in: PubMed
    38. Ramirez-Amaya V, Angulo-Perkins A, Chawla MK, Barnes CA, Rosi S. Sustained transcription of the immediate early gene Arc in the dentate gyrus after spatial exploration. J Neurosci. 2013 Jan 23; 33(4):1631-9. PMID: 23345235.
      View in: PubMed
    39. Belarbi K, Jopson T, Arellano C, Fike JR, Rosi S. CCR2 deficiency prevents neuronal dysfunction and cognitive impairments induced by cranial irradiation. Cancer Res. 2013 Feb 01; 73(3):1201-10. PMID: 23243025; PMCID: PMC3563875.
    40. Chakraborti A, Allen A, Allen B, Rosi S, Fike JR. Cranial irradiation alters dendritic spine density and morphology in the hippocampus. PLoS One. 2012; 7(7):e40844. PMID: 22815839; PMCID: PMC3397939.
    41. Tweedie D, Ferguson RA, Fishman K, Frankola KA, Van Praag H, Holloway HW, Luo W, Li Y, Caracciolo L, Russo I, Barlati S, Ray B, Lahiri DK, Bosetti F, Greig NH, Rosi S. Tumor necrosis factor-a synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease. J Neuroinflammation. 2012 May 29; 9:106. PMID: 22642825; PMCID: PMC3405480.
    42. Rosi S, Ferguson R, Fishman K, Allen A, Raber J, Fike JR. The polyamine inhibitor alpha-difluoromethylornithine modulates hippocampus-dependent function after single and combined injuries. PLoS One. 2012; 7(1):e31094. PMID: 22299052; PMCID: PMC3267765.
    43. Belarbi K, Jopson T, Tweedie D, Arellano C, Luo W, Greig NH, Rosi S. TNF-a protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation. J Neuroinflammation. 2012 Jan 25; 9:23. PMID: 22277195; PMCID: PMC3298520.
    44. Raber J, Rosi S, Chakraborti A, Fishman K, Dayger C, Davis MJ, Villasana L, Fike JR. Effects of 56Fe-particle cranial radiation on hippocampus-dependent cognition depend on the salience of the environmental stimuli. Radiat Res. 2011 Oct; 176(4):521-6. PMID: 21823976.
      View in: PubMed
    45. Belarbi K, Arellano C, Ferguson R, Jopson T, Rosi S. Chronic neuroinflammation impacts the recruitment of adult-born neurons into behaviorally relevant hippocampal networks. Brain Behav Immun. 2012 Jan; 26(1):18-23. PMID: 21787860; PMCID: PMC3221820.
    46. Acharya MM, Christie LA, Lan ML, Giedzinski E, Fike JR, Rosi S, Limoli CL. Human neural stem cell transplantation ameliorates radiation-induced cognitive dysfunction. Cancer Res. 2011 Jul 15; 71(14):4834-45. PMID: 21757460; PMCID: PMC3517293.
    47. Rosi S. Neuroinflammation and the plasticity-related immediate-early gene Arc. Brain Behav Immun. 2011 Jun; 25 Suppl 1:S39-49. PMID: 21320587; PMCID: PMC3098296.
    48. Rosi S, Belarbi K, Ferguson RA, Fishman K, Obenaus A, Raber J, Fike JR. Trauma-induced alterations in cognition and Arc expression are reduced by previous exposure to 56Fe irradiation. Hippocampus. 2012 Mar; 22(3):544-54. PMID: 21192069; PMCID: PMC3738213.
    49. Fike JR, Rosi S, Limoli CL. Neural precursor cells and central nervous system radiation sensitivity. Semin Radiat Oncol. 2009 Apr; 19(2):122-32. PMID: 19249650; PMCID: PMC2683587.
    50. Rosi S, Andres-Mach M, Fishman KM, Levy W, Ferguson RA, Fike JR. Cranial irradiation alters the behaviorally induced immediate-early gene arc (activity-regulated cytoskeleton-associated protein). Cancer Res. 2008 Dec 01; 68(23):9763-70. PMID: 19047155; PMCID: PMC2597278.
    51. Rola R, Fishman K, Baure J, Rosi S, Lamborn KR, Obenaus A, Nelson GA, Fike JR. Hippocampal neurogenesis and neuroinflammation after cranial irradiation with (56)Fe particles. Radiat Res. 2008 Jun; 169(6):626-32. PMID: 18494546; PMCID: PMC2583781.
    52. Rola R, Zou Y, Huang TT, Fishman K, Baure J, Rosi S, Milliken H, Limoli CL, Fike JR. Lack of extracellular superoxide dismutase (EC-SOD) in the microenvironment impacts radiation-induced changes in neurogenesis. Free Radic Biol Med. 2007 Apr 15; 42(8):1133-45; discussion 1131-2. PMID: 17382195; PMCID: PMC1934512.
    53. Vazdarjanova A, Ramirez-Amaya V, Insel N, Plummer TK, Rosi S, Chowdhury S, Mikhael D, Worley PF, Guzowski JF, Barnes CA. Spatial exploration induces ARC, a plasticity-related immediate-early gene, only in calcium/calmodulin-dependent protein kinase II-positive principal excitatory and inhibitory neurons of the rat forebrain. J Comp Neurol. 2006 Sep 20; 498(3):317-29. PMID: 16871537.
      View in: PubMed
    54. Ramírez-Amaya V, Vazdarjanova A, Mikhael D, Rosi S, Worley PF, Barnes CA. Spatial exploration-induced Arc mRNA and protein expression: evidence for selective, network-specific reactivation. J Neurosci. 2005 Feb 16; 25(7):1761-8. PMID: 15716412.
      View in: PubMed
    55. Rosi S, Ramirez-Amaya V, Vazdarjanova A, Worley PF, Barnes CA, Wenk GL. Neuroinflammation alters the hippocampal pattern of behaviorally induced Arc expression. J Neurosci. 2005 Jan 19; 25(3):723-31. PMID: 15659610.
      View in: PubMed
    56. Rosi S, Ramirez-Amaya V, Hauss-Wegrzyniak B, Wenk GL. Chronic brain inflammation leads to a decline in hippocampal NMDA-R1 receptors. J Neuroinflammation. 2004 Jul 07; 1(1):12. PMID: 15285803.
      View in: PubMed
    57. Rosi S, Giovannini MG, Lestage PJ, Muñoz C, Corte LD, Pepeu G. S 18986, a positive modulator of AMPA receptors with cognition-enhancing properties, increases ACh release in the hippocampus of young and aged rat. Neurosci Lett. 2004 May 06; 361(1-3):120-3. PMID: 15135908.
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    58. Wenk GL, McGann-Gramling K, Hauss-Wegrzyniak B, Ronchetti D, Maucci R, Rosi S, Gasparini L, Ongini E. Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid. J Neurochem. 2004 Apr; 89(2):484-93. PMID: 15056291.
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    59. Rosi S, McGann K, Hauss-Wegrzyniak B, Wenk GL. The influence of brain inflammation upon neuronal adenosine A2B receptors. J Neurochem. 2003 Jul; 86(1):220-7. PMID: 12807441.
      View in: PubMed
    60. Giovannini MG, Scali C, Prosperi C, Bellucci A, Vannucchi MG, Rosi S, Pepeu G, Casamenti F. Beta-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo: involvement of the p38MAPK pathway. Neurobiol Dis. 2002 Nov; 11(2):257-74. PMID: 12505419.
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    61. Wenk GL, Rosi S, McGann K, Hauss-Wegrzyniak B. A nitric oxide-donating flurbiprofen derivative reduces neuroinflammation without interacting with galantamine in the rat. Eur J Pharmacol. 2002 Oct 25; 453(2-3):319-24. PMID: 12398920.
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