Michael McManus, PhD

Title(s)Professor, Diabetes Center
SchoolSchool of Medicine
Address513 Parnassus Ave, HSW
San Francisco CA 94143
Phone415-476-4661
ORCID ORCID Icon0000-0003-3013-6569 Additional info
vCardDownload vCard

    Collapse Overview 
    Collapse Overview
    The McManus lab studies fundamental processes relating to the regulation of gene expression. We take high-throughput approaches, analyzing hundreds of thousands to millions of experiments at once, using unique and complex libraries coupled to deep sequencing. Our systems span from cell culture to in vivo models, focusing on a broad array of disease relevant tissues. From cancer to diabetes, we develop novel technologies to help us better understand how genes are regulated and how they function in cells. We aim to uncover the dark matter of the genome, to help unravel the beautiful genomic complexity of pathways and how genes interact in development and disease.

    Collapse Research 
    Collapse Research Activities and Funding
    Bay Area CRISPR Reporters
    NIH U42OD026647Sep 15, 2018 - Aug 31, 2021
    Role: Principal Investigator
    Illuminating Druggable Dark Matter
    NIH U24DK116214Sep 15, 2017 - Aug 31, 2023
    Role: Principal Investigator
    The Cancer Target Discovery and Development Network at UCSF
    NIH U01CA217882Aug 10, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Functional Networks for Persister Cell Sensitivities
    NIH R01CA212767Aug 1, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Regulation of developmental potency by the transposon LINE1
    NIH/NIGMS R01GM123556May 19, 2017 - Feb 28, 2021
    Role: Principal Investigator
    Tracing Cell Lineages
    NIH R01CA195770Sep 23, 2014 - Aug 31, 2019
    Role: Principal Investigator
    Empiric deconvolution of functional RNA elements
    NIH R01GM110251Aug 15, 2014 - Mar 31, 2019
    Role: Principal Investigator
    Unlocking the Hidden Kinome
    NIH U01MH105028Aug 1, 2014 - Jul 31, 2017
    Role: Principal Investigator
    Genetic models for exRNA communication
    NIH U19CA179513Sep 1, 2013 - Aug 31, 2018
    Role: Principal Investigator
    Bay Area Cancer Target Discovery and Development Network
    NIH U01CA168370May 1, 2012 - Apr 30, 2017
    Role: Principal Investigator
    Whole genome RNA-interference screen for novel regulators of the insulin promoter
    NIH RC1DK086290Sep 25, 2009 - Feb 29, 2012
    Role: Principal Investigator
    Resolving MicroRNA Targets
    NIH R01DA026065Jun 1, 2009 - May 31, 2011
    Role: Principal Investigator
    New Frontiers for Small RNA Therapies
    NIH R01GM080783Feb 1, 2007 - Jan 31, 2014
    Role: Principal Investigator
    The Epigenetics of Small RNAs in the Mammalian Brain
    NIH R03DA022201Sep 29, 2006 - Aug 31, 2009
    Role: Principal Investigator
    Diabetes Research Center
    NIH P30DK063720Sep 1, 2002 - Mar 31, 2021
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Student Projects

    Collapse Featured Content 
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. miR-200 deficiency promotes lung cancer metastasis by activating Notch signaling in cancer-associated fibroblasts. Genes Dev. 2021 Aug 01; 35(15-16):1109-1122. Xue B, Chuang CH, Prosser HM, Fuziwara CS, Chan C, Sahasrabudhe N, Kühn M, Wu Y, Chen J, Biton A, Chen C, Wilkinson JE, McManus MT, Bradley A, Winslow MM, Su B, He L. PMID: 34301766.
      View in: PubMed   Mentions:    Fields:    
    2. Examining the evidence for extracellular RNA function in mammals. Nat Rev Genet. 2021 07; 22(7):448-458. Gruner HN, McManus MT. PMID: 33824487.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. High-Throughput CRISPR Screening Identifies Genes Involved in Macrophage Viability and Inflammatory Pathways. Cell Rep. 2020 12 29; 33(13):108541. Covarrubias S, Vollmers AC, Capili A, Boettcher M, Shulkin A, Correa MR, Halasz H, Robinson EK, O'Briain L, Vollmers C, Blau J, Katzman S, McManus MT, Carpenter S. PMID: 33378675.
      View in: PubMed   Mentions:    Fields:    
    4. miR-29 Sustains B Cell Survival and Controls Terminal Differentiation via Regulation of PI3K Signaling. Cell Rep. 2020 12 01; 33(9):108436. Hines MJ, Coffre M, Mudianto T, Panduro M, Wigton EJ, Tegla C, Osorio-Vasquez V, Kageyama R, Benhamou D, Perez O, Bajwa S, McManus MT, Ansel KM, Melamed D, Koralov SB. PMID: 33264610.
      View in: PubMed   Mentions: 2     Fields:    
    5. Macrophage Exosomes Resolve Atherosclerosis by Regulating Hematopoiesis and Inflammation via MicroRNA Cargo. Cell Rep. 2020 07 14; 32(2):107881. Bouchareychas L, Duong P, Covarrubias S, Alsop E, Phu TA, Chung A, Gomes M, Wong D, Meechoovet B, Capili A, Yamamoto R, Nakauchi H, McManus MT, Carpenter S, Van Keuren-Jensen K, Raffai RL. PMID: 32668250.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    6. CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling. Cell. 2020 08 06; 182(3):563-577.e20. Oguri Y, Shinoda K, Kim H, Alba DL, Bolus WR, Wang Q, Brown Z, Pradhan RN, Tajima K, Yoneshiro T, Ikeda K, Chen Y, Cheang RT, Tsujino K, Kim CR, Greiner VJ, Datta R, Yang CD, Atabai K, McManus MT, Koliwad SK, Spiegelman BM, Kajimura S. PMID: 32615086.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    7. Host-Receptor Post-Translational Modifications Refine Staphylococcal Leukocidin Cytotoxicity. Toxins (Basel). 2020 02 06; 12(2). Tromp AT, Van Gent M, Jansen JP, Scheepmaker LM, Velthuizen A, De Haas CJC, Van Kessel KPM, Bardoel BW, Boettcher M, McManus MT, Van Strijp JAG, Lebbink RJ, Haas PA, Spaan AN. PMID: 32041354.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. Nature. 2019 08; 572(7771):614-619. Yoneshiro T, Wang Q, Tajima K, Matsushita M, Maki H, Igarashi K, Dai Z, White PJ, McGarrah RW, Ilkayeva OR, Deleye Y, Oguri Y, Kuroda M, Ikeda K, Li H, Ueno A, Ohishi M, Ishikawa T, Kim K, Chen Y, Sponton CH, Pradhan RN, Majd H, Greiner VJ, Yoneshiro M, Brown Z, Chondronikola M, Takahashi H, Goto T, Kawada T, Sidossis L, Szoka FC, McManus MT, Saito M, Soga T, Kajimura S. PMID: 31435015.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    9. miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival. Cell Rep. 2019 08 20; 28(8):2169-2181.e4. Gagnon JD, Kageyama R, Shehata HM, Fassett MS, Mar DJ, Wigton EJ, Johansson K, Litterman AJ, Odorizzi P, Simeonov D, Laidlaw BJ, Panduro M, Patel S, Jeker LT, Feeney ME, McManus MT, Marson A, Matloubian M, Sanjabi S, Ansel KM. PMID: 31433990.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    10. Genomic Resolution of DLX-Orchestrated Transcriptional Circuits Driving Development of Forebrain GABAergic Neurons. Cell Rep. 2019 08 20; 28(8):2048-2063.e8. Lindtner S, Catta-Preta R, Tian H, Su-Feher L, Price JD, Dickel DE, Greiner V, Silberberg SN, McKinsey GL, McManus MT, Pennacchio LA, Visel A, Nord AS, Rubenstein JLR. PMID: 31433982.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    11. Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area. Neuron. 2019 Jul 17; 103(2):349. Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY. PMID: 31319050.
      View in: PubMed   Mentions: 2     Fields:    
    12. Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area. Neuron. 2019 07 17; 103(2):309-322.e7. Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY. PMID: 31151773.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    13. High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions. Cell Rep. 2019 04 09; 27(2):631-647.e5. Mues M, Karra L, Romero-Moya D, Wandler A, Hangauer MJ, Ksionda O, Thus Y, Lindenbergh M, Shannon K, McManus MT, Roose JP. PMID: 30970263.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    14. The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research. Cell. 2019 04 04; 177(2):231-242. Das S, Extracellular RNA Communication Consortium , Ansel KM, Bitzer M, Breakefield XO, Charest A, Galas DJ, Gerstein MB, Gupta M, Milosavljevic A, McManus MT, Patel T, Raffai RL, Rozowsky J, Roth ME, Saugstad JA, Van Keuren-Jensen K, Weaver AM, Laurent LC. PMID: 30951667.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    15. Tracing cellular heterogeneity in pooled genetic screens via multi-level barcoding. BMC Genomics. 2019 Feb 06; 20(1):107. Boettcher M, Covarrubias S, Biton A, Blau J, Wang H, Zaitlen N, McManus MT. PMID: 30727954.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    16. Far away from the lamppost. PLoS Biol. 2018 12; 16(12):e3000067. Oprea TI, Jan L, Johnson GL, Roth BL, Ma'ayan A, Schürer S, Shoichet BK, Sklar LA, McManus MT. PMID: 30532236.
      View in: PubMed   Mentions: 4     Fields:    
    17. Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2. Cell Rep. 2018 11 06; 25(6):1511-1524.e6. Elling R, Robinson EK, Shapleigh B, Liapis SC, Covarrubias S, Katzman S, Groff AF, Jiang Z, Agarwal S, Motwani M, Chan J, Sharma S, Hennessy EJ, FitzGerald GA, McManus MT, Rinn JL, Fitzgerald KA, Carpenter S. PMID: 30404006.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    18. miR-205 Regulates Basal Cell Identity and Stem Cell Regenerative Potential During Mammary Reconstitution. Stem Cells. 2018 12; 36(12):1875-1889. Lu Y, Cao J, Napoli M, Xia Z, Zhao N, Creighton CJ, Li W, Chen X, Flores ER, McManus MT, Rosen JM. PMID: 30267595.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    19. Publisher Correction: Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton-Valentine leukocidin. Nat Microbiol. 2018 Oct; 3(10):1187. Tromp AT, Van Gent M, Abrial P, Martin A, Jansen JP, De Haas CJC, Van Kessel KPM, Bardoel BW, Kruse E, Bourdonnay E, Boettcher M, McManus MT, Day CJ, Jennings MP, Lina G, Vandenesch F, Van Strijp JAG, Lebbink RJ, Haas PA, Henry T, Spaan AN. PMID: 30177744.
      View in: PubMed   Mentions: 2     Fields:    
    20. A Genetic Interaction Map of Insulin Production Identifies Mfi as an Inhibitor of Mitochondrial Fission. Endocrinology. 2018 09 01; 159(9):3321-3330. Lee J, Pappalardo Z, Chopra DG, Hennings TG, Vaughn I, Lan C, Choe JJ, Ang K, Chen S, Arkin M, McManus MT, German MS, Ku GM. PMID: 30059978.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    21. Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton-Valentine leukocidin. Nat Microbiol. 2018 06; 3(6):708-717. Tromp AT, Van Gent M, Abrial P, Martin A, Jansen JP, De Haas CJC, Van Kessel KPM, Bardoel BW, Kruse E, Bourdonnay E, Boettcher M, McManus MT, Day CJ, Jennings MP, Lina G, Vandenesch F, Van Strijp JAG, Lebbink RJ, Haas PA, Henry T, Spaan AN. PMID: 29736038.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    22. Corrigendum: A systematic comparison reveals substantial differences in chromosomal versus episomal encoding of enhancer activity. Genome Res. 2018 05; 28(5):766.3. Inoue F, Kircher M, Martin B, Cooper GM, Witten DM, McManus MT, Ahituv N, Shendure J. PMID: 29717003.
      View in: PubMed   Mentions:    Fields:    
    23. Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation. Proc Natl Acad Sci U S A. 2018 04 24; 115(17):E4051-E4060. Shang W, Jiang Y, Boettcher M, Ding K, Mollenauer M, Liu Z, Wen X, Liu C, Hao P, Zhao S, McManus MT, Wei L, Weiss A, Wang H. PMID: 29632189.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    24. Unexplored therapeutic opportunities in the human genome. Nat Rev Drug Discov. 2018 05; 17(5):377. Oprea TI, Bologa CG, Brunak S, Campbell A, Gan GN, Gaulton A, Gomez SM, Guha R, Hersey A, Holmes J, Jadhav A, Jensen LJ, Johnson GL, Karlson A, Leach AR, Ma'ayan A, Malovannaya A, Mani S, Mathias SL, McManus MT, Meehan TF, von Mering C, Muthas D, Nguyen DT, Overington JP, Papadatos G, Qin J, Reich C, Roth BL, Schürer SC, Simeonov A, Sklar LA, Southall N, Tomita S, Tudose I, Ursu O, Vidovic D, Waller A, Westergaard D, Yang JJ, Zahoránszky-Köhalmi G. PMID: 29567993.
      View in: PubMed   Mentions: 10     Fields:    
    25. Unexplored therapeutic opportunities in the human genome. Nat Rev Drug Discov. 2018 05; 17(5):317-332. Oprea TI, Bologa CG, Brunak S, Campbell A, Gan GN, Gaulton A, Gomez SM, Guha R, Hersey A, Holmes J, Jadhav A, Jensen LJ, Johnson GL, Karlson A, Leach AR, Ma'ayan A, Malovannaya A, Mani S, Mathias SL, McManus MT, Meehan TF, von Mering C, Muthas D, Nguyen DT, Overington JP, Papadatos G, Qin J, Reich C, Roth BL, Schürer SC, Simeonov A, Sklar LA, Southall N, Tomita S, Tudose I, Ursu O, Vidovic D, Waller A, Westergaard D, Yang JJ, Zahoránszky-Köhalmi G. PMID: 29472638.
      View in: PubMed   Mentions: 64     Fields:    
    26. The Transcriptionally Permissive Chromatin State of Embryonic Stem Cells Is Acutely Tuned to Translational Output. Cell Stem Cell. 2018 03 01; 22(3):369-383.e8. Bulut-Karslioglu A, Macrae TA, Oses-Prieto JA, Covarrubias S, Percharde M, Ku G, Diaz A, McManus MT, Burlingame AL, Ramalho-Santos M. PMID: 29499153.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    27. Dual Strategies for Argonaute2-Mediated Biogenesis of Erythroid miRNAs Underlie Conserved Requirements for Slicing in Mammals. Mol Cell. 2018 01 18; 69(2):265-278.e6. Jee D, Yang JS, Park SM, Farmer DT, Wen J, Chou T, Chow A, McManus MT, Kharas MG, Lai EC. PMID: 29351846.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    28. Dual gene activation and knockout screen reveals directional dependencies in genetic networks. Nat Biotechnol. 2018 02; 36(2):170-178. Boettcher M, Tian R, Blau JA, Markegard E, Wagner RT, Wu D, Mo X, Biton A, Zaitlen N, Fu H, McCormick F, Kampmann M, McManus MT. PMID: 29334369.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    29. Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. Nature. 2017 11 09; 551(7679):247-250. Hangauer MJ, Viswanathan VS, Ryan MJ, Bole D, Eaton JK, Matov A, Galeas J, Dhruv HD, Berens ME, Schreiber SL, McCormick F, McManus MT. PMID: 29088702.
      View in: PubMed   Mentions: 212     Fields:    Translation:HumansAnimals
    30. CRISPR/Cas-based screening of long non-coding RNAs (lncRNAs) in macrophages with an NF-κB reporter. J Biol Chem. 2017 12 22; 292(51):20911-20920. Covarrubias S, Robinson EK, Shapleigh B, Vollmers A, Katzman S, Hanley N, Fong N, McManus MT, Carpenter S. PMID: 29051223.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    31. Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland. Development. 2017 07 01; 144(13):2517-2528. Farmer DT, Nathan S, Finley JK, Shengyang Yu K, Emmerson E, Byrnes LE, Sneddon JB, McManus MT, Tward AD, Knox SM. PMID: 28576768.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    32. miR-205 is a critical regulator of lacrimal gland development. Dev Biol. 2017 07 01; 427(1):12-20. Farmer DT, Finley JK, Chen FY, Tarifeño-Saldivia E, McNamara NA, Knox SM, McManus MT. PMID: 28511845.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    33. A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response. Diabetes. 2017 06; 66(6):1703-1712. Pappalardo Z, Gambhir Chopra D, Hennings TG, Richards H, Choe J, Yang K, Baeyens L, Ang K, Chen S, Arkin M, German MS, McManus MT, Ku GM. PMID: 28246293.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    34. MicroRNAs in ectodermal appendages. Curr Opin Genet Dev. 2017 Apr; 43:61-66. Farmer DT, McManus MT. PMID: 28103525.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    35. A systematic comparison reveals substantial differences in chromosomal versus episomal encoding of enhancer activity. Genome Res. 2017 01; 27(1):38-52. Inoue F, Kircher M, Martin B, Cooper GM, Witten DM, McManus MT, Ahituv N, Shendure J. PMID: 27831498.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    36. PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression. Nat Med. 2016 11; 22(11):1321-1329. Horiuchi D, Camarda R, Zhou AY, Yau C, Momcilovic O, Balakrishnan S, Corella AN, Eyob H, Kessenbrock K, Lawson DA, Marsh LA, Anderton BN, Rohrberg J, Kunder R, Bazarov AV, Yaswen P, McManus MT, Rugo HS, Werb Z, Goga A. PMID: 27775705.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    37. MicroRNAs 24 and 27 Suppress Allergic Inflammation and Target a Network of Regulators of T Helper 2 Cell-Associated Cytokine Production. Immunity. 2016 Apr 19; 44(4):821-32. Pua HH, Steiner DF, Patel S, Gonzalez JR, Ortiz-Carpena JF, Kageyama R, Chiou NT, Gallman A, de Kouchkovsky D, Jeker LT, McManus MT, Erle DJ, Ansel KM. PMID: 26850657.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    38. Biogenesis, delivery, and function of extracellular RNA. J Extracell Vesicles. 2015; 4:27494. Patton JG, Franklin JL, Weaver AM, Vickers K, Zhang B, Coffey RJ, Ansel KM, Blelloch R, Goga A, Huang B, L'Etoille N, Raffai RL, Lai CP, Krichevsky AM, Mateescu B, Greiner VJ, Hunter C, Voinnet O, McManus MT. PMID: 26320939.
      View in: PubMed   Mentions:
    39. Identification of MiR-205 As a MicroRNA That Is Highly Expressed in Medullary Thymic Epithelial Cells. PLoS One. 2015; 10(8):e0135440. Khan IS, Park CY, Mavropoulos A, Shariat N, Pollack JL, Barczak AJ, Erle DJ, McManus MT, Anderson MS, Jeker LT. PMID: 26270036.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    40. Choosing the Right Tool for the Job: RNAi, TALEN, or CRISPR. Mol Cell. 2015 May 21; 58(4):575-85. Boettcher M, McManus MT. PMID: 26000843.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimals
    41. Integrative analysis of 111 reference human epigenomes. Nature. 2015 Feb 19; 518(7539):317-30. Roadmap Epigenomics Consortium , Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon G, Sandstrom RS, Eaton ML, Wu YC, Pfenning AR, Wang X, Claussnitzer M, Liu Y, Coarfa C, Harris RA, Shoresh N, Epstein CB, Gjoneska E, Leung D, Xie W, Hawkins RD, Lister R, Hong C, Gascard P, Mungall AJ, Moore R, Chuah E, Tam A, Canfield TK, Hansen RS, Kaul R, Sabo PJ, Bansal MS, Carles A, Dixon JR, Farh KH, Feizi S, Karlic R, Kim AR, Kulkarni A, Li D, Lowdon R, Elliott G, Mercer TR, Neph SJ, Onuchic V, Polak P, Rajagopal N, Ray P, Sallari RC, Siebenthall KT, Sinnott-Armstrong NA, Stevens M, Thurman RE, Wu J, Zhang B, Zhou X, Beaudet AE, Boyer LA, De Jager PL, Farnham PJ, Fisher SJ, Haussler D, Jones SJ, Li W, Marra MA, McManus MT, Sunyaev S, Thomson JA, Tlsty TD, Tsai LH, Wang W, Waterland RA, Zhang MQ, Chadwick LH, Bernstein BE, Costello JF, Ecker JR, Hirst M, Meissner A, Milosavljevic A, Ren B, Stamatoyannopoulos JA, Wang T, Kellis M. PMID: 25693563.
      View in: PubMed   Mentions: 2057     Fields:    Translation:HumansCells
    42. Epigenetic and transcriptional determinants of the human breast. Nat Commun. 2015 Feb 18; 6:6351. Gascard P, Bilenky M, Sigaroudinia M, Zhao J, Li L, Carles A, Delaney A, Tam A, Kamoh B, Cho S, Griffith M, Chu A, Robertson G, Cheung D, Li I, Heravi-Moussavi A, Moksa M, Mingay M, Hussainkhel A, Davis B, Nagarajan RP, Hong C, Echipare L, O'Geen H, Hangauer MJ, Cheng JB, Neel D, Hu D, McManus MT, Moore R, Mungall A, Ma Y, Plettner P, Ziv E, Wang T, Farnham PJ, Jones SJ, Marra MA, Tlsty TD, Costello JF, Hirst M. PMID: 25690954.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    43. A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver. Hepatology. 2015 Jan; 61(1):141-52. Mattis AN, Song G, Hitchner K, Kim RY, Lee AY, Sharma AD, Malato Y, McManus MT, Esau CC, Koller E, Koliwad S, Lim LP, Maher JJ, Raffai RL, Willenbring H. PMID: 25131933.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    44. Systematic identification of barriers to human iPSC generation. Cell. 2014 Jul 17; 158(2):449-461. Qin H, Diaz A, Blouin L, Lebbink RJ, Patena W, Tanbun P, LeProust EM, McManus MT, Song JS, Ramalho-Santos M. PMID: 25036638.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    45. A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation. Nat Commun. 2014 May 08; 5:3832. van de Weijer ML, Bassik MC, Luteijn RD, Voorburg CM, Lohuis MA, Kremmer E, Hoeben RC, LeProust EM, Chen S, Hoelen H, Ressing ME, Patena W, Weissman JS, McManus MT, Wiertz EJ, Lebbink RJ. PMID: 24807418.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    46. Discovering the complexity of the metazoan transcriptome. Genome Biol. 2014 Apr 29; 15(4):112. Hangauer MJ, Carpenter S, McManus MT. PMID: 25001157.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    47. Massively parallel functional annotation of 3' untranslated regions. Nat Biotechnol. 2014 Apr; 32(4):387-91. Zhao W, Pollack JL, Blagev DP, Zaitlen N, McManus MT, Erle DJ. PMID: 24633241.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    48. Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210. Nat Immunol. 2014 Apr; 15(4):393-401. Wang H, Flach H, Onizawa M, Wei L, McManus MT, Weiss A. PMID: 24608041.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    49. Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem Biol. 2013 Nov 21; 20(11):1352-63. Matheny CJ, Wei MC, Bassik MC, Donnelly AJ, Kampmann M, Iwasaki M, Piloto O, Solow-Cordero DE, Bouley DM, Rau R, Brown P, McManus MT, Weissman JS, Cleary ML. PMID: 24183972.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    50. Partially penetrant postnatal lethality of an epithelial specific MicroRNA in a mouse knockout. PLoS One. 2013; 8(10):e76634. Farmer DT, Shariat N, Park CY, Liu HJ, Mavropoulos A, McManus MT. PMID: 24116130.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    51. The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation. Development. 2013 Aug; 140(16):3348-59. Cao H, Jheon A, Li X, Sun Z, Wang J, Florez S, Zhang Z, McManus MT, Klein OD, Amendt BA. PMID: 23863486.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    52. Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs. PLoS Genet. 2013 Jun; 9(6):e1003569. Hangauer MJ, Vaughn IW, McManus MT. PMID: 23818866.
      View in: PubMed   Mentions: 282     Fields:    Translation:HumansCells
    53. Renewable RNAi. Nat Biotechnol. 2013 Apr; 31(4):319-20. Blau JA, McManus MT. PMID: 23563428.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    54. A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. Cell. 2013 Feb 14; 152(4):909-22. Bassik MC, Kampmann M, Lebbink RJ, Wang S, Hein MY, Poser I, Weibezahn J, Horlbeck MA, Chen S, Mann M, Hyman AA, Leproust EM, McManus MT, Weissman JS. PMID: 23394947.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansCells
    55. T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. J Exp Med. 2013 Feb 11; 210(2):417-32. Bronevetsky Y, Villarino AV, Eisley CJ, Barbeau R, Barczak AJ, Heinz GA, Kremmer E, Heissmeyer V, McManus MT, Erle DJ, Rao A, Ansel KM. PMID: 23382546.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    56. IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science. 2012 Nov 09; 338(6108):818-22. Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA. PMID: 23042294.
      View in: PubMed   Mentions: 239     Fields:    Translation:HumansAnimalsCells
    57. Research resource: RNA-Seq reveals unique features of the pancreatic β-cell transcriptome. Mol Endocrinol. 2012 Oct; 26(10):1783-92. Ku GM, Kim H, Vaughn IW, Hangauer MJ, Myung Oh C, German MS, McManus MT. PMID: 22915829.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    58. Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP. PLoS Genet. 2012; 8(7):e1002823. Repetto E, Briata P, Kuziner N, Harfe BD, McManus MT, Gherzi R, Rosenfeld MG, Trabucchi M. PMID: 22844247.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    59. Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing. Nucleic Acids Res. 2012 Oct; 40(18):9255-71. Dallas A, Ilves H, Ge Q, Kumar P, Shorenstein J, Kazakov SA, Cuellar TL, McManus MT, Behlke MA, Johnston BH. PMID: 22810205.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    60. A resource for the conditional ablation of microRNAs in the mouse. Cell Rep. 2012 Apr 19; 1(4):385-91. Park CY, Jeker LT, Carver-Moore K, Oh A, Liu HJ, Cameron R, Richards H, Li Z, Adler D, Yoshinaga Y, Martinez M, Nefadov M, Abbas AK, Weiss A, Lanier LL, de Jong PJ, Bluestone JA, Srivastava D, McManus MT. PMID: 22570807.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    61. Precursor microRNA-programmed silencing complex assembly pathways in mammals. Mol Cell. 2012 May 25; 46(4):507-17. Liu X, Jin DY, McManus MT, Mourelatos Z. PMID: 22503104.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    62. Widespread RNA 3'-end oligouridylation in mammals. RNA. 2012 Mar; 18(3):394-401. Choi YS, Patena W, Leavitt AD, McManus MT. PMID: 22291204.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    63. An siRNA screen in pancreatic beta cells reveals a role for Gpr27 in insulin production. PLoS Genet. 2012 Jan; 8(1):e1002449. Ku GM, Pappalardo Z, Luo CC, German MS, McManus MT. PMID: 22253604.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    64. Polymerase II promoter strength determines efficacy of microRNA adapted shRNAs. PLoS One. 2011; 6(10):e26213. Lebbink RJ, Lowe M, Chan T, Khine H, Wang X, McManus MT. PMID: 22031824.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    65. The microRNA-processing enzyme Dicer is dispensable for somite segmentation but essential for limb bud positioning. Dev Biol. 2011 Mar 15; 351(2):254-65. Zhang Z, O'Rourke JR, McManus MT, Lewandoski M, Harfe BD, Sun X. PMID: 21256124.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    66. Posttranscriptional silencing of effector cytokine mRNA underlies the anergic phenotype of self-reactive T cells. Immunity. 2011 Jan 28; 34(1):50-60. Villarino AV, Katzman SD, Gallo E, Miller O, Jiang S, McManus MT, Abbas AK. PMID: 21236706.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    67. Analysis of microRNA knockouts in mice. Hum Mol Genet. 2010 Oct 15; 19(R2):R169-75. Park CY, Choi YS, McManus MT. PMID: 20805106.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimals
    68. Dicer1 and miR-219 Are required for normal oligodendrocyte differentiation and myelination. Neuron. 2010 Mar 11; 65(5):597-611. Dugas JC, Cuellar TL, Scholze A, Ason B, Ibrahim A, Emery B, Zamanian JL, Foo LC, McManus MT, Barres BA. PMID: 20223197.
      View in: PubMed   Mentions: 232     Fields:    Translation:AnimalsCells
    69. Dicer ablation in oligodendrocytes provokes neuronal impairment in mice. Ann Neurol. 2009 Dec; 66(6):843-57. Shin D, Shin JY, McManus MT, Ptácek LJ, Fu YH. PMID: 20035504.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    70. Expanded RNA-binding activities of mammalian Argonaute 2. Nucleic Acids Res. 2009 Dec; 37(22):7533-45. Tan GS, Garchow BG, Liu X, Yeung J, Morris JP, Cuellar TL, McManus MT, Kiriakidou M. PMID: 19808937.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    71. Dicer is required for proper liver zonation. J Pathol. 2009 Nov; 219(3):365-72. Sekine S, Ogawa R, Mcmanus MT, Kanai Y, Hebrok M. PMID: 19718708.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    72. Lentivirus production. J Vis Exp. 2009 Oct 02; (32). Wang X, McManus M. PMID: 19801965.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    73. Chd1 regulates open chromatin and pluripotency of embryonic stem cells. Nature. 2009 Aug 13; 460(7257):863-8. Gaspar-Maia A, Alajem A, Polesso F, Sridharan R, Mason MJ, Heidersbach A, Ramalho-Santos J, McManus MT, Plath K, Meshorer E, Ramalho-Santos M. PMID: 19587682.
      View in: PubMed   Mentions: 247     Fields:    Translation:AnimalsCells
    74. Rapid creation and quantitative monitoring of high coverage shRNA libraries. Nat Methods. 2009 Jun; 6(6):443-5. Bassik MC, Lebbink RJ, Churchman LS, Ingolia NT, Patena W, LeProust EM, Schuldiner M, Weissman JS, McManus MT. PMID: 19448642.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    75. LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages. FASEB J. 2009 Sep; 23(9):2898-908. Ruggiero T, Trabucchi M, De Santa F, Zupo S, Harfe BD, McManus MT, Rosenfeld MG, Briata P, Gherzi R. PMID: 19423639.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    76. Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion. J Biol Chem. 2009 Jul 03; 284(27):18515-24. Huang TH, Wu F, Loeb GB, Hsu R, Heidersbach A, Brincat A, Horiuchi D, Lebbink RJ, Mo YY, Goga A, McManus MT. PMID: 19419954.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    77. Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis. Gastroenterology. 2009 Jun; 136(7):2304-2315.e1-4. Sekine S, Ogawa R, Ito R, Hiraoka N, McManus MT, Kanai Y, Hebrok M. PMID: 19272382.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    78. Characterization of the 1-aminocyclopropane-1-carboxylic acid (ACC) oxidase multigene family of Malus domestica Borkh. Phytochemistry. 2009 Feb; 70(3):348-60. Binnie JE, McManus MT. PMID: 19223050.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    79. Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice. Dev Biol. 2009 Apr 15; 328(2):328-41. Soukup GA, Fritzsch B, Pierce ML, Weston MD, Jahan I, McManus MT, Harfe BD. PMID: 19389351.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    80. Genetic analyses reveal a requirement for Dicer1 in the mouse urogenital tract. Mamm Genome. 2009 Mar; 20(3):140-51. Pastorelli LM, Wells S, Fray M, Smith A, Hough T, Harfe BD, McManus MT, Smith L, Woolf AS, Cheeseman M, Greenfield A. PMID: 19169742.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimals
    81. Sertoli cell Dicer is essential for spermatogenesis in mice. Dev Biol. 2009 Feb 01; 326(1):250-9. Papaioannou MD, Pitetti JL, Ro S, Park C, Aubry F, Schaad O, Vejnar CE, Kühne F, Descombes P, Zdobnov EM, McManus MT, Guillou F, Harfe BD, Yan W, Jégou B, Nef S. PMID: 19071104.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    82. Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. J Am Soc Nephrol. 2008 Nov; 19(11):2150-8. Harvey SJ, Jarad G, Cunningham J, Goldberg S, Schermer B, Harfe BD, McManus MT, Benzing T, Miner JH. PMID: 18776121.
      View in: PubMed   Mentions: 156     Fields:    Translation:AnimalsCells
    83. Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J Exp Med. 2008 Sep 01; 205(9):1983-91. Zhou X, Jeker LT, Fife BT, Zhu S, Anderson MS, McManus MT, Bluestone JA. PMID: 18725525.
      View in: PubMed   Mentions: 255     Fields:    Translation:AnimalsCells
    84. Dicer1 is required for differentiation of the mouse male germline. Biol Reprod. 2008 Oct; 79(4):696-703. Maatouk DM, Loveland KL, McManus MT, Moore K, Harfe BD. PMID: 18633141.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    85. Mouse let-7 miRNA populations exhibit RNA editing that is constrained in the 5'-seed/ cleavage/anchor regions and stabilize predicted mmu-let-7a:mRNA duplexes. Genome Res. 2008 Oct; 18(10):1571-81. Reid JG, Nagaraja AK, Lynn FC, Drabek RB, Muzny DM, Shaw CA, Weiss MK, Naghavi AO, Khan M, Zhu H, Tennakoon J, Gunaratne GH, Corry DB, Miller J, McManus MT, German MS, Gibbs RA, Matzuk MM, Gunaratne PH. PMID: 18614752.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    86. Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci. 2008 May 07; 28(19):4878-87. Damiani D, Alexander JJ, O'Rourke JR, McManus M, Jadhav AP, Cepko CL, Hauswirth WW, Harfe BD, Strettoi E. PMID: 18463241.
      View in: PubMed   Mentions: 112     Fields:    Translation:Animals
    87. Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J Neurosci. 2008 Apr 23; 28(17):4322-30. Davis TH, Cuellar TL, Koch SM, Barker AJ, Harfe BD, McManus MT, Ullian EM. PMID: 18434510.
      View in: PubMed   Mentions: 222     Fields:    Translation:AnimalsCells
    88. Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration. Proc Natl Acad Sci U S A. 2008 Apr 08; 105(14):5614-9. Cuellar TL, Davis TH, Nelson PT, Loeb GB, Harfe BD, Ullian E, McManus MT. PMID: 18385371.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    89. Michael T. McManus: Interrupting biology [interview by Hema Bashyam]. J Exp Med. 2008 Mar 17; 205(3):506-7. McManus MT. PMID: 18347104.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    90. Unintentional miRNA ablation is a risk factor in gene knockout studies: a short report. PLoS Genet. 2008 Feb; 4(2):e34. Osokine I, Hsu R, Loeb GB, McManus MT. PMID: 18282110.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    91. Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron. 2008 Jan 10; 57(1):41-55. Choi PS, Zakhary L, Choi WY, Caron S, Alvarez-Saavedra E, Miska EA, McManus M, Harfe B, Giraldez AJ, Horvitz HR, Schier AF, Dulac C. PMID: 18184563.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    92. Behind the scenes of a small RNA gene-silencing pathway. Hum Gene Ther. 2008 Jan; 19(1):17-26. Ku G, McManus MT. PMID: 18211225.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    93. Further examination of abscission zone cells as ethylene target cells in higher plants. Ann Bot. 2008 Jan; 101(2):285-92. McManus MT. PMID: 17965027.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    94. MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes. 2007 Dec; 56(12):2938-45. Lynn FC, Skewes-Cox P, Kosaka Y, McManus MT, Harfe BD, German MS. PMID: 17804764.
      View in: PubMed   Mentions: 153     Fields:    Translation:Animals
    95. Essential role for Dicer during skeletal muscle development. Dev Biol. 2007 Nov 15; 311(2):359-68. O'Rourke JR, Georges SA, Seay HR, Tapscott SJ, McManus MT, Goldhamer DJ, Swanson MS, Harfe BD. PMID: 17936265.
      View in: PubMed   Mentions: 150     Fields:    Translation:HumansAnimalsCells
    96. Complex formation between recombinant ATP sulfurylase and APS reductase of Allium cepa (L.). FEBS Lett. 2007 Sep 04; 581(22):4139-47. Cumming M, Leung S, McCallum J, McManus MT. PMID: 17692849.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    97. Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells. PLoS One. 2007 Apr 25; 2(4):e392. Nawroth R, van Zante A, Cervantes S, McManus M, Hebrok M, Rosen SD. PMID: 17460759.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansCells
    98. Lentiviral strategies for RNAi knockdown of neuronal genes. Curr Protoc Neurosci. 2007 Apr; Chapter 5:Unit 5.26. Crittenden JR, Heidersbach A, McManus MT. PMID: 18428658.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    99. Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell. 2007 Apr 20; 129(2):303-17. Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, Tsuchihashi T, McManus MT, Schwartz RJ, Srivastava D. PMID: 17397913.
      View in: PubMed   Mentions: 587     Fields:    Translation:AnimalsCells
    100. Duox2 exhibits potent heme peroxidase activity in human respiratory tract epithelium. FEBS Lett. 2006 Oct 02; 580(22):5150-4. Harper RW, Xu C, McManus M, Heidersbach A, Eiserich JP. PMID: 16970942.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    101. RNA interference in embryonic stem cells and the prospects for future therapies. Gene Ther. 2006 Mar; 13(6):478-86. Heidersbach A, Gaspar-Maia A, McManus MT, Ramalho-Santos M. PMID: 16520820.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    102. Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2208-13. Harris KS, Zhang Z, McManus MT, Harfe BD, Sun X. PMID: 16452165.
      View in: PubMed   Mentions: 200     Fields:    Translation:AnimalsCells
    103. MicroRNAs and endocrine biology. J Endocrinol. 2005 Dec; 187(3):327-32. Cuellar TL, McManus MT. PMID: 16423811.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    104. The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development. Nature. 2005 Dec 01; 438(7068):671-4. Hornstein E, Mansfield JH, Yekta S, Hu JK, Harfe BD, McManus MT, Baskerville S, Bartel DP, Tabin CJ. PMID: 16319892.
      View in: PubMed   Mentions: 159     Fields:    Translation:AnimalsCells
    105. Slowing down the Ras lane: miRNAs as tumor suppressors? Sci STKE. 2005 Aug 16; 2005(297):pe41. Morris JP, McManus MT. PMID: 16107327.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    106. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science. 2005 Aug 12; 309(5737):1074-8. Hong JH, Hwang ES, McManus MT, Amsterdam A, Tian Y, Kalmukova R, Mueller E, Benjamin T, Spiegelman BM, Sharp PA, Hopkins N, Yaffe MB. PMID: 16099986.
      View in: PubMed   Mentions: 372     Fields:    Translation:HumansAnimalsCells
    107. The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A. 2005 Aug 02; 102(31):10898-903. Harfe BD, McManus MT, Mansfield JH, Hornstein E, Tabin CJ. PMID: 16040801.
      View in: PubMed   Mentions: 329     Fields:    Translation:AnimalsCells
    108. Small RNAs and immunity. Immunity. 2004 Dec; 21(6):747-56. McManus MT. PMID: 15589164.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    109. MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet. 2004 Oct; 36(10):1079-83. Mansfield JH, Harfe BD, Nissen R, Obenauer J, Srineel J, Chaudhuri A, Farzan-Kashani R, Zuker M, Pasquinelli AE, Ruvkun G, Sharp PA, Tabin CJ, McManus MT. PMID: 15361871.
      View in: PubMed   Mentions: 162     Fields:    Translation:AnimalsCells
    110. Cre-lox-regulated conditional RNA interference from transgenes. Proc Natl Acad Sci U S A. 2004 Jul 13; 101(28):10380-5. Ventura A, Meissner A, Dillon CP, McManus M, Sharp PA, Van Parijs L, Jaenisch R, Jacks T. PMID: 15240889.
      View in: PubMed   Mentions: 285     Fields:    Translation:AnimalsCells
    111. MicroRNAs and cancer. Semin Cancer Biol. 2003 Aug; 13(4):253-8. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, McManus MT. PMID: 14563119.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimals
    112. RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2718-23. Ge Q, McManus MT, Nguyen T, Shen CH, Sharp PA, Eisen HN, Chen J. PMID: 12594334.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansAnimalsCells
    113. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet. 2003 Mar; 33(3):401-6. Rubinson DA, Dillon CP, Kwiatkowski AV, Sievers C, Yang L, Kopinja J, Rooney DL, Zhang M, Ihrig MM, McManus MT, Gertler FB, Scott ML, Van Parijs L. PMID: 12590264.
      View in: PubMed   Mentions: 525     Fields:    Translation:AnimalsCells
    114. Small interfering RNA-mediated gene silencing in T lymphocytes. J Immunol. 2002 Nov 15; 169(10):5754-60. McManus MT, Haines BB, Dillon CP, Whitehurst CE, van Parijs L, Chen J, Sharp PA. PMID: 12421955.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    115. Gene silencing in mammals by small interfering RNAs. Nat Rev Genet. 2002 Oct; 3(10):737-47. McManus MT, Sharp PA. PMID: 12360232.
      View in: PubMed   Mentions: 323     Fields:    Translation:HumansAnimalsCells
    116. CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. Dev Cell. 2002 Sep; 3(3):339-50. Chen Z, Indjeian VB, McManus M, Wang L, Dynlacht BD. PMID: 12361598.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansCells
    117. Gene silencing using micro-RNA designed hairpins. RNA. 2002 Jun; 8(6):842-50. McManus MT, Petersen CP, Haines BB, Chen J, Sharp PA. PMID: 12088155.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansCells
    118. Identification of candidate mitochondrial RNA editing ligases from Trypanosoma brucei. RNA. 2001 Feb; 7(2):167-75. McManus MT, Shimamura M, Grams J, Hajduk SL. PMID: 11233974.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    119. Processing of polycistronic guide RNAs is associated with RNA editing complexes in Trypanosoma brucei. EMBO J. 2000 Oct 16; 19(20):5525-32. Grams J, McManus MT, Hajduk SL. PMID: 11032819.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    120. Trypanosoma brucei guide RNA poly(U) tail formation is stabilized by cognate mRNA. Mol Cell Biol. 2000 Feb; 20(3):883-91. McManus MT, Adler BK, Pollard VW, Hajduk SL. PMID: 10629045.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    121. Biochemical methods for analysis of kinetoplastid RNA editing. Methods. 1998 May; 15(1):15-26. Sabatini RS, Adler BK, Madison-Antenucci S, McManus MT, Hajduk SL. PMID: 9614649.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    122. Insertional and deletional RNA editing in trypanosome mitochondria. Nucleic Acids Symp Ser. 1997; (36):15-8. Hajduk SL, Adler B, Madison-Antenucci S, McManus M, Sabatini R. PMID: 9478193.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    Michael's Networks
    Concepts (654)
    Derived automatically from this person's publications.
    _
    Co-Authors (86)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _