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Bone Marrow-Derived Alk1 Mutant Endothelial Cells and Clonally Expanded Somatic Alk1 Mutant Endothelial Cells Contribute to the Development of Brain Arteriovenous Malformations in Mice. Transl Stroke Res. 2021 Oct 21.
Shaligram SS, Zhang R, Zhu W, Ma L, Luo M, Li Q, Weiss M, Arnold T, Santander N, Liang R, do Prado L, Tang C, Pan F, Oh SP, Pan P, Su H. PMID: 34674144.
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αVβ8 integrin targeting to prevent posterior capsular opacification (PCO). JCI Insight. 2021 Sep 23.
Shihan MH, Novo SG, Wang Y, Sheppard D, Atakilit A, Arnold TD, Rossi NM, Faranda AP, Duncan MK. PMID: 34554928.
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Enrichment of Vascular Fragments from Mouse Embryonic Brains for Endothelial Cell Analysis. Bio Protoc. 2021 Jun 20; 11(12):e4058.
Santander N, Arnold TD. PMID: 34263001.
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CNS fibroblasts form a fibrotic scar in response to immune cell infiltration. Nat Neurosci. 2021 02; 24(2):234-244.
Dorrier CE, Aran D, Haenelt EA, Sheehy RN, Hoi KK, Pintaric L, Chen Y, Lizama CO, Cautivo KM, Weiner GA, Popko B, Fancy SPJ, Arnold TD, Daneman R. PMID: 33526922.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier. J Clin Invest. 2020 08 03; 130(8):4055-4068.
Santander N, Lizama CO, Meky E, McKinsey GL, Jung B, Sheppard D, Betsholtz C, Arnold TD. PMID: 32369453.
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2 Fields:
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AnimalsCells
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A new genetic strategy for targeting microglia in development and disease. Elife. 2020 06 23; 9.
McKinsey GL, Lizama CO, Keown-Lang AE, Niu A, Santander N, Larpthaveesarp A, Chee E, Gonzalez FF, Arnold TD. PMID: 32573436.
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16 Fields:
Translation:
AnimalsCells
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Disruption of the Extracellular Matrix Progressively Impairs Central Nervous System Vascular Maturation Downstream of β-Catenin Signaling. Arterioscler Thromb Vasc Biol. 2019 07; 39(7):1432-1447.
Jensen LD, Hot B, Ramsköld D, Germano RFV, Yokota C, Giatrellis S, Lauschke VM, Hubmacher D, Li MX, Hupe M, Arnold TD, Sandberg R, Frisén J, Trusohamn M, Martowicz A, Wisniewska-Kruk J, Nyqvist D, Adams RH, Apte SS, Vanhollebeke B, Stenman JM, Kele J. PMID: 31242033.
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2 Fields:
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AnimalsCells
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Impaired αVβ8 and TGFβ signaling lead to microglial dysmaturation and neuromotor dysfunction. J Exp Med. 2019 04 01; 216(4):900-915.
Arnold TD, Lizama CO, Cautivo KM, Santander N, Lin L, Qiu H, Huang EJ, Liu C, Mukouyama YS, Reichardt LF, Zovein AC, Sheppard D. PMID: 30846482.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Tissue Myeloid Progenitors Differentiate into Pericytes through TGF-β Signaling in Developing Skin Vasculature. Cell Rep. 2017 03 21; 18(12):2991-3004.
Yamazaki T, Nalbandian A, Uchida Y, Li W, Arnold TD, Kubota Y, Yamamoto S, Ema M, Mukouyama YS. PMID: 28329690.
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34 Fields:
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AnimalsCells
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Visualization of vascular mural cells in developing brain using genetically labeled transgenic reporter mice. J Cereb Blood Flow Metab. 2018 03; 38(3):456-468.
Jung B, Arnold TD, Raschperger E, Gaengel K, Betsholtz C. PMID: 28276839.
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19 Fields:
Translation:
AnimalsCells
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The αvβ1 integrin plays a critical in vivo role in tissue fibrosis. Sci Transl Med. 2015 May 20; 7(288):288ra79.
Reed NI, Jo H, Chen C, Tsujino K, Arnold TD, DeGrado WF, Sheppard D. PMID: 25995225.
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81 Fields:
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AnimalsCells
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LSR/angulin-1 is a tricellular tight junction protein involved in blood-brain barrier formation. J Cell Biol. 2015 Mar 16; 208(6):703-11.
Sohet F, Lin C, Munji RN, Lee SY, Ruderisch N, Soung A, Arnold TD, Derugin N, Vexler ZS, Yen FT, Daneman R. PMID: 25753034.
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31 Fields:
Translation:
AnimalsCells
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Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain. Development. 2014 Dec; 141(23):4489-99.
Arnold TD, Niaudet C, Pang MF, Siegenthaler J, Gaengel K, Jung B, Ferrero GM, Mukouyama YS, Fuxe J, Akhurst R, Betsholtz C, Sheppard D, Reichardt LF. PMID: 25406396.
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36 Fields:
Translation:
AnimalsCells
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Mesangial cell αvβ8-integrin regulates glomerular capillary integrity and repair. Am J Physiol Renal Physiol. 2014 Jun 15; 306(12):F1400-9.
Lakhe-Reddy S, Li V, Arnold TD, Khan S, Schelling JR. PMID: 24740792.
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6 Fields:
Translation:
AnimalsCells
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Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med. 2013 Dec; 19(12):1617-24.
Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D. PMID: 24216753.
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303 Fields:
Translation:
AnimalsCells
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Deletion of integrin-linked kinase from neural crest cells in mice results in aortic aneurysms and embryonic lethality. Dis Model Mech. 2013 Sep; 6(5):1205-12.
Arnold TD, Zang K, Vallejo-Illarramendi A. PMID: 23744273.
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5 Fields:
Translation:
AnimalsCells
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Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanism. PLoS Biol. 2013; 11(4):e1001527.
Shang Y, Doan CN, Arnold TD, Lee S, Tang AA, Reichardt LF, Huang EJ. PMID: 23565059.
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22 Fields:
Translation:
HumansAnimalsCells
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Ocean acidification and the loss of phenolic substances in marine plants. PLoS One. 2012; 7(4):e35107.
Arnold T, Mealey C, Leahey H, Miller AW, Hall-Spencer JM, Milazzo M, Maers K. PMID: 22558120.
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33 Fields:
Translation:
Animals
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Defective retinal vascular endothelial cell development as a consequence of impaired integrin αVβ8-mediated activation of transforming growth factor-β. J Neurosci. 2012 Jan 25; 32(4):1197-206.
Arnold TD, Ferrero GM, Qiu H, Phan IT, Akhurst RJ, Huang EJ, Reichardt LF. PMID: 22279205.
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30 Fields:
Translation:
AnimalsCells
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Analysis of genomewide association signals for nonsyndromic cleft lip/palate in a Kenya African Cohort. . 2011 Oct; 155A(10):2422-25.
Weatherley-White RC, Ben S, Jin Y, Riccardi S, Arnold TD, Spritz RA. PMID: 22043487.
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7 Translation:
Humans
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From death to recovery following hypoxia ischemia: if TGFbeta is a central regulator, is integrin beta8 the switch? Neurotox Res. 2010 May; 17(4):418-20.
Arnold TD, McQuillen PS. PMID: 20039156.
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Translation:
HumansAnimals
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Distribution of orofacial clefts and frequent occurrence of an unusual cleft variant in the Rift Valley of Kenya. Cleft Palate Craniofac J. 2007 Jul; 44(4):374-7.
Spritz RA, Arnold TD, Buonocore S, Carter D, Fingerlin T, Odero WW, Wambani JO, Tenge RK, Weatherley-White RC. PMID: 17608554.
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PubMed Mentions:
4 Fields:
Translation:
Humans