Tom Arnold, MD

Title(s)Associate Professor, Pediatrics
SchoolSchool of Medicine
Address1550 Fourth St, #548C
San Francisco CA 94158
Phone415-476-1034
ORCID ORCID Icon0000-0002-7310-5597 Additional info
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Finding the right tool: a comprehensive evaluation of microglial inducible cre mouse models. bioRxiv. 2023 Apr 17. Bedolla A, Mckinsey G, Ware K, Santander N, Arnold T, Luo Y. PMID: 37131606; PMCID: PMC10153116.
      View in: PubMed   Mentions:
    2. MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4γ-dependent transcription of CES enzymes. Cell Rep. 2023 03 28; 42(3):112249. Datta R, Gholampour MA, Yang CD, Volk R, Lin S, Podolsky MJ, Arnold T, Rieder F, Zaro BW, Verzi M, Lehner R, Abumrad N, Lizama CO, Atabai K. PMID: 36924494; PMCID: PMC10138282.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research. Stem Cell Reports. 2022 05 10; 17(5):1089-1104. Muhl L, He L, Sun Y, Andaloussi Mäe M, Pietilä R, Liu J, Genové G, Zhang L, Xie Y, Leptidis S, Mocci G, Stritt S, Osman A, Anisimov A, Hemanthakumar KA, Räsänen M, Hansson EM, Björkegren J, Vanlandewijck M, Blomgren K, Mäkinen T, Peng XR, Hu Y, Ernfors P, Arnold TD, Alitalo K, Lendahl U, Betsholtz C. PMID: 35452595; PMCID: PMC9022216.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    4. Microglia are involved in the protection of memories formed during sleep deprivation. Neurobiol Sleep Circadian Rhythms. 2022 May; 12:100073. Gentry NW, McMahon T, Yamazaki M, Webb J, Arnold TD, Rosi S, Ptácek LJ, Fu YH. PMID: 35028489; PMCID: PMC8741522.
      View in: PubMed   Mentions: 3  
    5. αVβ8 integrin targeting to prevent posterior capsular opacification. JCI Insight. 2021 11 08; 6(21). Shihan MH, Novo SG, Wang Y, Sheppard D, Atakilit A, Arnold TD, Rossi NM, Faranda AP, Duncan MK. PMID: 34554928; PMCID: PMC8663568.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    6. Bone Marrow-Derived Alk1 Mutant Endothelial Cells and Clonally Expanded Somatic Alk1 Mutant Endothelial Cells Contribute to the Development of Brain Arteriovenous Malformations in Mice. Transl Stroke Res. 2022 06; 13(3):494-504. Shaligram SS, Zhang R, Zhu W, Ma L, Luo M, Li Q, Weiss M, Arnold T, Santander N, Liang R, do Prado L, Tang C, Pan F, Oh SP, Pan P, Su H. PMID: 34674144; PMCID: PMC9021325.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    7. Enrichment of Vascular Fragments from Mouse Embryonic Brains for Endothelial Cell Analysis. Bio Protoc. 2021 Jun 20; 11(12):e4058. Santander N, Arnold TD. PMID: 34263001; PMCID: PMC8260263.
      View in: PubMed   Mentions:
    8. CNS fibroblasts form a fibrotic scar in response to immune cell infiltration. Nat Neurosci. 2021 02; 24(2):234-244. Dorrier CE, Aran D, Haenelt EA, Sheehy RN, Hoi KK, Pintaric L, Chen Y, Lizama CO, Cautivo KM, Weiner GA, Popko B, Fancy SPJ, Arnold TD, Daneman R. PMID: 33526922; PMCID: PMC7877789.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    9. Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier. J Clin Invest. 2020 08 03; 130(8):4055-4068. Santander N, Lizama CO, Meky E, McKinsey GL, Jung B, Sheppard D, Betsholtz C, Arnold TD. PMID: 32369453; PMCID: PMC7410045.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    10. A new genetic strategy for targeting microglia in development and disease. Elife. 2020 06 23; 9. McKinsey GL, Lizama CO, Keown-Lang AE, Niu A, Santander N, Larpthaveesarp A, Chee E, Gonzalez FF, Arnold TD. PMID: 32573436; PMCID: PMC7375817.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    11. Disruption of the Extracellular Matrix Progressively Impairs Central Nervous System Vascular Maturation Downstream of β-Catenin Signaling. Arterioscler Thromb Vasc Biol. 2019 07; 39(7):1432-1447. Jensen LD, Hot B, Ramsköld D, Germano RFV, Yokota C, Giatrellis S, Lauschke VM, Hubmacher D, Li MX, Hupe M, Arnold TD, Sandberg R, Frisén J, Trusohamn M, Martowicz A, Wisniewska-Kruk J, Nyqvist D, Adams RH, Apte SS, Vanhollebeke B, Stenman JM, Kele J. PMID: 31242033; PMCID: PMC6597191.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    12. Impaired αVβ8 and TGFβ signaling lead to microglial dysmaturation and neuromotor dysfunction. J Exp Med. 2019 04 01; 216(4):900-915. Arnold TD, Lizama CO, Cautivo KM, Santander N, Lin L, Qiu H, Huang EJ, Liu C, Mukouyama YS, Reichardt LF, Zovein AC, Sheppard D. PMID: 30846482; PMCID: PMC6446869.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    13. Tissue Myeloid Progenitors Differentiate into Pericytes through TGF-β Signaling in Developing Skin Vasculature. Cell Rep. 2017 03 21; 18(12):2991-3004. Yamazaki T, Nalbandian A, Uchida Y, Li W, Arnold TD, Kubota Y, Yamamoto S, Ema M, Mukouyama YS. PMID: 28329690; PMCID: PMC5393447.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    14. Visualization of vascular mural cells in developing brain using genetically labeled transgenic reporter mice. J Cereb Blood Flow Metab. 2018 03; 38(3):456-468. Jung B, Arnold TD, Raschperger E, Gaengel K, Betsholtz C. PMID: 28276839; PMCID: PMC5851136.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    15. The αvβ1 integrin plays a critical in vivo role in tissue fibrosis. Sci Transl Med. 2015 May 20; 7(288):288ra79. Reed NI, Jo H, Chen C, Tsujino K, Arnold TD, DeGrado WF, Sheppard D. PMID: 25995225; PMCID: PMC4461057.
      View in: PubMed   Mentions: 115     Fields:    Translation:AnimalsCells
    16. LSR/angulin-1 is a tricellular tight junction protein involved in blood-brain barrier formation. J Cell Biol. 2015 Mar 16; 208(6):703-11. Sohet F, Lin C, Munji RN, Lee SY, Ruderisch N, Soung A, Arnold TD, Derugin N, Vexler ZS, Yen FT, Daneman R. PMID: 25753034; PMCID: PMC4362448.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    17. Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain. Development. 2014 Dec; 141(23):4489-99. Arnold TD, Niaudet C, Pang MF, Siegenthaler J, Gaengel K, Jung B, Ferrero GM, Mukouyama YS, Fuxe J, Akhurst R, Betsholtz C, Sheppard D, Reichardt LF. PMID: 25406396; PMCID: PMC4302931.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    18. Mesangial cell αvβ8-integrin regulates glomerular capillary integrity and repair. Am J Physiol Renal Physiol. 2014 Jun 15; 306(12):F1400-9. Lakhe-Reddy S, Li V, Arnold TD, Khan S, Schelling JR. PMID: 24740792; PMCID: PMC4059974.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    19. Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med. 2013 Dec; 19(12):1617-24. Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D. PMID: 24216753; PMCID: PMC3855865.
      View in: PubMed   Mentions: 398     Fields:    Translation:AnimalsCells
    20. Deletion of integrin-linked kinase from neural crest cells in mice results in aortic aneurysms and embryonic lethality. Dis Model Mech. 2013 Sep; 6(5):1205-12. Arnold TD, Zang K, Vallejo-Illarramendi A. PMID: 23744273; PMCID: PMC3759340.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    21. Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanism. PLoS Biol. 2013; 11(4):e1001527. Shang Y, Doan CN, Arnold TD, Lee S, Tang AA, Reichardt LF, Huang EJ. PMID: 23565059; PMCID: PMC3614511.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    22. Ocean acidification and the loss of phenolic substances in marine plants. PLoS One. 2012; 7(4):e35107. Arnold T, Mealey C, Leahey H, Miller AW, Hall-Spencer JM, Milazzo M, Maers K. PMID: 22558120; PMCID: PMC3338829.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    23. Defective retinal vascular endothelial cell development as a consequence of impaired integrin αVβ8-mediated activation of transforming growth factor-β. J Neurosci. 2012 Jan 25; 32(4):1197-206. Arnold TD, Ferrero GM, Qiu H, Phan IT, Akhurst RJ, Huang EJ, Reichardt LF. PMID: 22279205; PMCID: PMC3578416.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    24. Analysis of genomewide association signals for nonsyndromic cleft lip/palate in a Kenya African Cohort. Am J Med Genet A. 2011 Oct; 155A(10):2422-25. Weatherley-White RC, Ben S, Jin Y, Riccardi S, Arnold TD, Spritz RA. PMID: 22043487.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    25. From death to recovery following hypoxia ischemia: if TGFbeta is a central regulator, is integrin beta8 the switch? Neurotox Res. 2010 May; 17(4):418-20. Arnold TD, McQuillen PS. PMID: 20039156; PMCID: PMC2835727.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    26. Distribution of orofacial clefts and frequent occurrence of an unusual cleft variant in the Rift Valley of Kenya. Cleft Palate Craniofac J. 2007 Jul; 44(4):374-7. Spritz RA, Arnold TD, Buonocore S, Carter D, Fingerlin T, Odero WW, Wambani JO, Tenge RK, Weatherley-White RC. PMID: 17608554.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
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