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Yuet Kan, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, HSW
San Francisco CA 94143
Phone415-476-5841
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    Research Interests: The mechanisms of globin production and exploring novel ways of inserting genes into mammalian cells; investigating newer approaches for fetal diagnosis of genetic disorders.

    Research Summary: The research in our laboratory is focused on the study of two inherited blood diseases; sickle cell anemia and thalassemia. These two diseases constitute the most common genetic diseases in the world and they affect people of African, Mediterranean, Middle East, and Asian origins. At present, treatment mostly consists of treatment of symptoms and complications. Bone marrow or cord blood transfusion can be curative when compatible donors can be found. However, since most of these families have a small number of children, only a minority of patients can be treated by transplantation.

    An effective way of preventing genetic diseases such as sickle cell anemia and thalassemia is by carrier screening, genetic counseling, and prenatal diagnosis. Our laboratory has been involved in prenatal diagnosis from the 1970s. Currently, amniocentesis and chorionic villus sampling is used to obtain DNA for diagnosis. We are investigating the isolation of fetal cells from the mother’s blood for testing so that an invasive procedure to the fetus can be avoided.
    Out laboratory is also investigating gene and cell therapy for treating these conditions. In a thalassemia, the affected fetus usually dies in the third trimester or soon after birth. We have explored in utero gene therapy to treat this condition. Using a mouse model of alpha thalassemia that we have previously made, we introduced to the mouse embryo at the 14th day of gestation a lentiviral vector that contained the human alpha globin gene. Preliminary studies showed that human alpha globin was expressed at moderately levels. Our plan is to see if these vectors can rescue the fetal mouse affected by homozygous a thalassemia.

    The mutations in sickle cell anemia and most clinically important ß thalassemia lie in the ß globin gene. Therefore, the approach to stem cell therapy for both is similar. We first tested embryonic stem cell therapy for a mouse model of sickle cell anemia. We made embryonic stem cells from a sickle cell anemia mouse, corrected the mutation by homologous recombination, differentiated the stem cells into hematopoietic cells and showed that the blood cells made hemoglobin A in additional to hemoglobin S.

    To apply this treatment for the human diseases, it will be necessary to use nuclear transfer in stem cells in order to avoid immunological rejection. However, nuclear transfer to make embryonic stem cell has not been successful in humans. Also, the procedure is complicated, requires egg donors from normal individuals and raises ethical concern. With the description of induced pluripotent stem (iPS) cells, we have now changed to this approach for the treatment of these conditions. Our laboratory has successfully made iPS cells from mouse and human fibroblasts by retroviral delivery of transcription vectors.

    Currently, we are working on correcting mutation in these iPS cells and differentiate them into hematopoietic cells. The future goal to treatment is to take skin cells from patients, differentiate them into iPS cells, correct the mutations by homologous recombination, and differentiate into the hematopoietic cells and re-infuse them into the patients. Since the cells originate from the patients, there would not be immuno-rejection. In order to achieve this goal, several conditions must first be met. First, to convert the skin cell into IPs cell it is necessary to use retrovirus induction. However, integration of retrovirus may disturb vital gene functions. Second, a reliable way of differentiating iPS cells into hematopoietic cells has to be established. We feel strongly that this approach will provide a means for curing these diseases.

    Collapse Research 
    Collapse Research Activities and Funding
    Development of iPS Cells for Treatment of Hemoglobinopathies
    NIH/NIDDK P01DK088760Sep 30, 2011 - Jul 31, 2016
    Role: Principal Investigator
    Northern California Comprehensive Sickle Cell Centers
    NIH U54HL070583Jul 1, 2003 - Mar 31, 2010
    Role: Co-Investigator
    AAV Mediated Angiogenic Therapy for Coronary Disease
    NIH/NHLBI R01HL067969Dec 5, 2002 - Nov 30, 2006
    Role: Principal Investigator
    Gene Therapy for Hemophilia
    NIH U01HL066948Sep 28, 2000 - Aug 31, 2007
    Role: Co-Investigator
    Basic Research in Hematology and Oncology
    NIH/NIDDK T32DK007636Feb 1, 1999 - Mar 31, 2014
    Role: Co-Principal Investigator
    MURINE MODELS TO INVESTIGATE THE HEMATOLOGIC SYSTEM
    NIH/NIDDK P01DK050267Aug 1, 1997 - Jul 31, 2001
    Role: Principal Investigator
    GENE THERAPY STRATEGIES FOR SICKLE CELL DISEASE
    NIH/NHLBI P01HL053762Sep 30, 1994 - Aug 31, 2007
    Role: Principal Investigator
    GENE THERAPY CORE--CYSTIC FIBROSIS &NON-CF GENETIC DIS
    NIH/NIDDK P30DK047766Sep 30, 1993 - Aug 31, 1999
    Role: Principal Investigator
    CENTER OF EXCELLENCE IN MOLECULAR HEMATOLOGY
    NIH/NIDDK P20DK047455Sep 30, 1993 - Aug 31, 1995
    Role: Principal Investigator
    BASIC RESEARCH IN HEMATOLOGY AND ONCOLOGY
    NIH/NCI T32CA009463May 1, 1984 - Jan 31, 1989
    Role: Principal Investigator
    NORTHERN CALIFORNIA COMPREHENSIVE SICKLE CELL CENTER
    NIH P60HL020985Apr 1, 1978 - Mar 31, 2004
    Role: Co-Investigator
    Abnormal Hemoglobin Synthesis -- Mechanism and Detection
    NIH/NIDDK R01DK016666Aug 1, 1976 - Jul 31, 2006
    Role: Principal Investigator
    ABNORMAL HEMOGLOBIN SYNTHESIS--MECHANISM AND DETECTION
    NIH/NIDDK R37DK016666Aug 1, 1976 - Jul 31, 2002
    Role: Principal Investigator
    ABNORMAL HEMOGLOBIN SYNTHESIS--MECHANISM &DETECTION
    NIH/NIADDK R01AM016666Aug 1, 1976 - Jul 31, 1986
    Role: Principal Investigator
    California National Primate Research Center
    NIH P51RR000169Jun 1, 1975 - Apr 30, 2015
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Genetically-edited induced pluripotent stem cells derived from HIV-1-infected patients on therapy can give rise to immune cells resistant to HIV-1 infection. AIDS. 2020 07 01; 34(8):1141-1149. Teque F, Ye L, Xie F, Wang J, Morvan MG, Kan YW, Levy JA. PMID: 32287059.
      View in: PubMed   Mentions: 1     Fields:    
    2. Biochar as simultaneous shelter, adsorbent, pH buffer, and substrate of Pseudomonas citronellolis to promote biodegradation of high concentrations of phenol in wastewater. Water Res. 2020 Apr 01; 172:115494. Zhao L, Xiao D, Liu Y, Xu H, Nan H, Li D, Kan Y, Cao X. PMID: 31954934.
      View in: PubMed   Mentions:    Fields:    Translation:CellsPHPublic Health
    3. CRISPR/Cas9-mediated gene deletion efficiently retards the progression of Philadelphia-positive acute lymphoblastic leukemia in a p210 BCR-ABL1T315I mutation mouse model. Haematologica. 2020 May; 105(5):e232-e236. Tan YT, Ye L, Xie F, Wang J, Müschen M, Chen SJ, Kan YW, Liu H. PMID: 31537693.
      View in: PubMed   Mentions:    Fields:    
    4. Infiltration behavior of heavy metals in runoff through soil amended with biochar as bulking agent. Environ Pollut. 2019 Nov; 254(Pt B):113114. Zhao L, Nan H, Kan Y, Xu X, Qiu H, Cao X. PMID: 31491698.
      View in: PubMed   Mentions:    Fields:    
    5. Respecifying human iPSC-derived blood cells into highly engraftable hematopoietic stem and progenitor cells with a single factor. Proc Natl Acad Sci U S A. 2018 02 27; 115(9):2180-2185. Tan YT, Ye L, Xie F, Beyer AI, Muench MO, Wang J, Chen Z, Liu H, Chen SJ, Kan YW. PMID: 29386396.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    6. Interaction of microRNA-21/145 and Smad3 domain-specific phosphorylation in hepatocellular carcinoma. Oncotarget. 2017 Oct 17; 8(49):84958-84973. Wang JY, Fang M, Boye A, Wu C, Wu JJ, Ma Y, Hou S, Kan Y, Yang Y. PMID: 29156696.
      View in: PubMed   Mentions: 1     Fields:    
    7. Role of Inherent Inorganic Constituents in SO2 Sorption Ability of Biochars Derived from Three Biomass Wastes. Environ Sci Technol. 2016 Dec 06; 50(23):12957-12965. Xu X, Huang D, Zhao L, Kan Y, Cao X. PMID: 27792316.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    8. Genome editing using CRISPR-Cas9 to create the HPFH genotype in HSPCs: An approach for treating sickle cell disease and ß-thalassemia. Proc Natl Acad Sci U S A. 2016 09 20; 113(38):10661-5. Ye L, Wang J, Tan Y, Beyer AI, Xie F, Muench MO, Kan YW. PMID: 27601644.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    9. Reversible Immortalization Enables Seamless Transdifferentiation of Primary Fibroblasts into Other Lineage Cells. Stem Cells Dev. 2016 08 15; 25(16):1243-8. Xie F, Gong K, Li K, Zhang M, Chang JC, Jiang S, Ye L, Wang J, Tan Y, Kan YW. PMID: 27328768.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    10. Chemical transformation of CO2 during its capture by waste biomass derived biochars. Environ Pollut. 2016 Jun; 213:533-540. Xu X, Kan Y, Zhao L, Cao X. PMID: 26995449.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    11. TALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs. Mol Ther Nucleic Acids. 2016 Jan 05; 5:e273. Suzuki S, Sargent RG, Illek B, Fischer H, Esmaeili-Shandiz A, Yezzi MJ, Lee A, Yang Y, Kim S, Renz P, Qi Z, Yu J, Muench MO, Beyer AI, Guimarães AO, Ye L, Chang J, Fine EJ, Cradick TJ, Bao G, Rahdar M, Porteus MH, Shuto T, Kai H, Kan YW, Gruenert DC. PMID: 26730810.
      View in: PubMed   Mentions:
    12. Phosphorus-assisted biomass thermal conversion: reducing carbon loss and improving biochar stability. PLoS One. 2014; 9(12):e115373. Zhao L, Cao X, Zheng W, Kan Y. PMID: 25531111.
      View in: PubMed   Mentions: 1     Fields:    
    13. Seamless gene correction of ß-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac. Genome Res. 2014 Sep; 24(9):1526-33. Xie F, Ye L, Chang JC, Beyer AI, Wang J, Muench MO, Kan YW. PMID: 25096406.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
    14. Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5?32 mutation confers resistance to HIV infection. Proc Natl Acad Sci U S A. 2014 Jul 01; 111(26):9591-6. Ye L, Wang J, Beyer AI, Teque F, Cradick TJ, Qi Z, Chang JC, Bao G, Muench MO, Yu J, Levy JA, Kan YW. PMID: 24927590.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansCells
    15. Blood cell-derived induced pluripotent stem cells free of reprogramming factors generated by Sendai viral vectors. Stem Cells Transl Med. 2013 Aug; 2(8):558-66. Ye L, Muench MO, Fusaki N, Beyer AI, Wang J, Qi Z, Yu J, Kan YW. PMID: 23847002.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    16. The prevention of thalassemia. Cold Spring Harb Perspect Med. 2013 Feb 01; 3(2):a011775. Cao A, Kan YW. PMID: 23378598.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    17. Generation of induced pluripotent stem cells using site-specific integration with phage integrase. Proc Natl Acad Sci U S A. 2010 Nov 09; 107(45):19467-72. Ye L, Chang JC, Lin C, Qi Z, Yu J, Kan YW. PMID: 20974949.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    18. Molecular diagnosis of hemoglobinopathies and thalassemia. Prenat Diagn. 2010 Jul; 30(7):608-10. Kan YW, Chang JC. PMID: 20572100.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. Signalling molecules involved in mouse bladder smooth muscle cellular differentiation. Int J Dev Biol. 2010; 54(1):175-80. Liu B, Feng D, Lin G, Cao M, Kan YW, Cunha GR, Baskin LS. PMID: 20013655.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    20. Combining angiogenic gene and stem cell therapies for myocardial infarction. J Gene Med. 2009 Sep; 11(9):743-53. Pons J, Huang Y, Takagawa J, Arakawa-Hoyt J, Ye J, Grossman W, Kan YW, Su H. PMID: 19554624.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    21. Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases. Proc Natl Acad Sci U S A. 2009 Jun 16; 106(24):9826-30. Ye L, Chang JC, Lin C, Sun X, Yu J, Kan YW. PMID: 19482945.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
    22. Permanent coronary artery occlusion: cardiovascular MR imaging is platform for percutaneous transendocardial delivery and assessment of gene therapy in canine model. Radiology. 2008 Nov; 249(2):560-71. Saeed M, Martin A, Jacquier A, Bucknor M, Saloner D, Do L, Ursell P, Su H, Kan YW, Higgins CB. PMID: 18780824.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    23. Additive effect of AAV-mediated angiopoietin-1 and VEGF expression on the therapy of infarcted heart. Int J Cardiol. 2009 Apr 03; 133(2):191-7. Su H, Takagawa J, Huang Y, Arakawa-Hoyt J, Pons J, Grossman W, Kan YW. PMID: 18295361.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    24. High oxygen environment during pregnancy rescues sickle cell anemia mice from prenatal death. Blood Cells Mol Dis. 2008 Jul-Aug; 41(1):67-72. Ye L, Chang JC, Lu R, Kan YW. PMID: 18207438.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    25. AAV serotype 1 mediates more efficient gene transfer to pig myocardium than AAV serotype 2 and plasmid. J Gene Med. 2008 Jan; 10(1):33-41. Su H, Yeghiazarians Y, Lee A, Huang Y, Arakawa-Hoyt J, Ye J, Orcino G, Grossman W, Kan YW. PMID: 18044793.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    26. Fetal gene therapy of alpha-thalassemia in a mouse model. Proc Natl Acad Sci U S A. 2007 May 22; 104(21):9007-11. Han XD, Lin C, Chang J, Sadelain M, Kan YW. PMID: 17496141.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    27. Adeno-associated viral vector-delivered hypoxia-inducible gene expression in ischemic hearts. Methods Mol Biol. 2007; 366:331-42. Su H, Kan YW. PMID: 17568134.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    28. Recombinant adeno-associated viral vector encoding human VEGF165 induces neomicrovessel formation in the adult mouse brain. Front Biosci. 2006 Sep 01; 11:3190-8. Shen F, Su H, Liu W, Kan YW, Young WL, Yang GY. PMID: 16720385.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    29. AAV serotype-1 mediates early onset of gene expression in mouse hearts and results in better therapeutic effect. Gene Ther. 2006 Nov; 13(21):1495-502. Su H, Huang Y, Takagawa J, Barcena A, Arakawa-Hoyt J, Ye J, Grossman W, Kan YW. PMID: 16775632.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    30. Yuet Wai Kan, MD: sickle cell and thalassemia pioneer. Interview by Tracy Hampton. JAMA. 2006 Mar 01; 295(9):991. Kan YW. PMID: 16507792.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    31. Correction of the sickle cell mutation in embryonic stem cells. Proc Natl Acad Sci U S A. 2006 Jan 24; 103(4):1036-40. Chang JC, Ye L, Kan YW. PMID: 16407095.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    32. The binding of the ubiquitous transcription factor Sp1 at the locus control region represses the expression of beta-like globin genes. Proc Natl Acad Sci U S A. 2005 Jul 12; 102(28):9896-900. Feng D, Kan YW. PMID: 15998736.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    33. Adeno-associated viral vector delivers cardiac-specific and hypoxia-inducible VEGF expression in ischemic mouse hearts. Proc Natl Acad Sci U S A. 2004 Nov 16; 101(46):16280-5. Su H, Joho S, Huang Y, Barcena A, Arakawa-Hoyt J, Grossman W, Kan YW. PMID: 15534198.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    34. Adeno-associated viral vector-mediated gene transfer of VEGF normalizes skeletal muscle oxygen tension and induces arteriogenesis in ischemic rat hindlimb. Mol Ther. 2003 Jan; 7(1):44-51. Chang DS, Su H, Tang GL, Brevetti LS, Sarkar R, Wang R, Kan YW, Messina LM. PMID: 12573617.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    35. Adeno-associated viral vector-mediated hypoxia response element-regulated gene expression in mouse ischemic heart model. Proc Natl Acad Sci U S A. 2002 Jul 09; 99(14):9480-5. Su H, Arakawa-Hoyt J, Kan YW. PMID: 12084814.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    36. An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4611-6. Chan K, Han XD, Kan YW. PMID: 11287661.
      View in: PubMed   Mentions: 221     Fields:    Translation:AnimalsCells
    37. Antibodies to human fetal erythroid cells from a nonimmune phage antibody library. Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5):2682-7. Huie MA, Cheung MC, Muench MO, Becerril B, Kan YW, Marks JD. PMID: 11226299.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    38. Adeno-associated viral vector-mediated vascular endothelial growth factor gene transfer induces neovascular formation in ischemic heart. Proc Natl Acad Sci U S A. 2000 Dec 05; 97(25):13801-6. Su H, Lu R, Kan YW. PMID: 11095751.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    39. The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts. J Biol Chem. 1999 Dec 24; 274(52):37491-8. Kwong M, Kan YW, Chan JY. PMID: 10601325.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    40. Nrf2 is essential for protection against acute pulmonary injury in mice. Proc Natl Acad Sci U S A. 1999 Oct 26; 96(22):12731-6. Chan K, Kan YW. PMID: 10535991.
      View in: PubMed   Mentions: 150     Fields:    Translation:AnimalsCells
    41. Transgenic knockout mice exclusively expressing human hemoglobin S after transfer of a 240-kb betas-globin yeast artificial chromosome: A mouse model of sickle cell anemia. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14886-90. Chang JC, Lu R, Lin C, Xu SM, Kan YW, Porcu S, Carlson E, Kitamura M, Yang S, Flebbe-Rehwaldt L, Gaensler KM. PMID: 9843985.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    42. Alterations in protein-DNA interactions in the gamma-globin gene promoter in response to butyrate therapy. Blood. 1998 Oct 15; 92(8):2924-33. Ikuta T, Kan YW, Swerdlow PS, Faller DV, Perrine SP. PMID: 9763579.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    43. Efficient expression of CFTR function with adeno-associated virus vectors that carry shortened CFTR genes. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):10158-63. Zhang L, Wang D, Fischer H, Fan PD, Widdicombe JH, Kan YW, Dong JY. PMID: 9707617.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    44. Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice. EMBO J. 1998 Mar 16; 17(6):1779-87. Chan JY, Kwong M, Lu R, Chang J, Wang B, Yen TS, Kan YW. PMID: 9501099.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    45. Tissue-specific expression of herpes simplex virus thymidine kinase gene delivered by adeno-associated virus inhibits the growth of human hepatocellular carcinoma in athymic mice. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):13891-6. Su H, Lu R, Chang JC, Kan YW. PMID: 9391123.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    46. NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc Natl Acad Sci U S A. 1996 Nov 26; 93(24):13943-8. Chan K, Lu R, Chang JC, Kan YW. PMID: 8943040.
      View in: PubMed   Mentions: 218     Fields:    Translation:HumansAnimalsCells
    47. Prenatal diagnosis of sickle cell anaemia and thalassaemia by analysis of fetal cells in maternal blood. Nat Genet. 1996 Nov; 14(3):264-8. Cheung MC, Goldberg JD, Kan YW. PMID: 8896554.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    48. Inactivation of mouse alpha-globin gene by homologous recombination: mouse model of hemoglobin H disease. Blood. 1996 Sep 01; 88(5):1846-51. Chang J, Lu RH, Xu SM, Meneses J, Chan K, Pedersen R, Kan YW. PMID: 8781443.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    49. Globin gene switching. In vivo protein-DNA interactions of the human beta-globin locus in erythroid cells expressing the fetal or the adult globin gene program. J Biol Chem. 1996 Jun 14; 271(24):14082-91. Ikuta T, Papayannopoulou T, Stamatoyannopoulos G, Kan YW. PMID: 8662960.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    50. Selective killing of AFP-positive hepatocellular carcinoma cells by adeno-associated virus transfer of the herpes simplex virus thymidine kinase gene. Hum Gene Ther. 1996 Mar 01; 7(4):463-70. Su H, Chang JC, Xu SM, Kan YW. PMID: 8800740.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    51. Thymic epithelial neoplasms in transgenic mice expressing SV40 T antigen under the control of an erythroid-specific enhancer. J Pathol. 1995 Nov; 177(3):309-15. Teitz T, Chang JC, Kan YW, Yen TS. PMID: 8551394.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    52. SV40 T antigen directed by a powerful erythroid enhancer-promoter produced sarcomas and pancreatic tumors but not erythroid-specific tumors in transgenic mice. DNA Cell Biol. 1994 Jul; 13(7):705-10. Teitz T, Yen TS, Chang JC, Kan YW. PMID: 7772251.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    53. Reverse dot blot probes for the screening of beta-thalassemia mutations in Asians and American blacks. Hum Mutat. 1994; 3(1):59-63. Cai SP, Wall J, Kan YW, Chehab FF. PMID: 8118466.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    54. Rhabdomyosarcoma arising in transgenic mice harboring the beta-globin locus control region fused with simian virus 40 large T antigen gene. Proc Natl Acad Sci U S A. 1993 Apr 01; 90(7):2910-4. Teitz T, Chang JC, Kitamura M, Yen TS, Kan YW. PMID: 7681991.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    55. Dissection of the enhancer activity of beta-globin 5' DNase I-hypersensitive site 2 in transgenic mice. Proc Natl Acad Sci U S A. 1992 May 01; 89(9):3899-903. Liu D, Chang JC, Moi P, Liu W, Kan YW, Curtin PT. PMID: 1570310.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    56. A 36-base-pair core sequence of locus control region enhances retrovirally transferred human beta-globin gene expression. Proc Natl Acad Sci U S A. 1992 Apr 01; 89(7):3107-10. Chang JC, Liu D, Kan YW. PMID: 1557419.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    57. Development of DNA analysis for human diseases. Sickle cell anemia and thalassemia as a paradigm. JAMA. 1992 Mar 18; 267(11):1532-6. Kan YW. PMID: 1538544.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    58. Amplification and detection of specific DNA sequences with fluorescent PCR primers: application to delta F508 mutation in cystic fibrosis. Methods Enzymol. 1992; 216:135-43. Chehab FF, Wall J, Kan YW. PMID: 1479898.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    59. Molecular biology of hemoglobin: its application to sickle cell anemia and thalassemia. Schweiz Med Wochenschr Suppl. 1991; 43:51-4. Kan YW. PMID: 1726857.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    60. Molecular analysis of insertion/deletion mutations in protein 4.1 in elliptocytosis. II. Determination of molecular genetic origins of rearrangements. J Clin Invest. 1990 Aug; 86(2):524-30. Conboy J, Marchesi S, Kim R, Agre P, Kan YW, Mohandas N. PMID: 2384598.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    61. Prenatal diagnosis of thalassemia in south China. Ann N Y Acad Sci. 1990; 612:264-7. Zhang JZ, Cai SP, Kan YW. PMID: 2291553.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    62. Human beta-globin gene expression in transgenic mice is enhanced by a distant DNase I hypersensitive site. Proc Natl Acad Sci U S A. 1989 Sep; 86(18):7082-6. Curtin PT, Liu DP, Liu W, Chang JC, Kan YW. PMID: 2780563.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    63. Multiple protein 4.1 isoforms produced by alternative splicing in human erythroid cells. Proc Natl Acad Sci U S A. 1988 Dec; 85(23):9062-5. Conboy JG, Chan J, Mohandas N, Kan YW. PMID: 3194408.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    64. Butyrate infusions in the ovine fetus delay the biologic clock for globin gene switching. Proc Natl Acad Sci U S A. 1988 Nov; 85(22):8540-2. Perrine SP, Rudolph A, Faller DV, Roman C, Cohen RA, Chen SJ, Kan YW. PMID: 2460870.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    65. 5' nucleotide sequence of a putative human placental alkaline phosphatase-like gene. Nucleic Acids Res. 1988 Jun 24; 16(12):5694. Shen LP, Liu H, Kan YW, Kam W. PMID: 3387245.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    66. A simple approach to prenatal diagnosis of beta-thalassemia in a geographic area where multiple mutations occur. Blood. 1988 May; 71(5):1357-60. Cai SP, Zhang JZ, Huang DH, Wang ZX, Kan YW. PMID: 3359045.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    67. Platelet glycoprotein IIb. Chromosomal localization and tissue expression. J Clin Invest. 1987 Dec; 80(6):1812-7. Bray PF, Rosa JP, Johnston GI, Shiu DT, Cook RG, Lau C, Kan YW, McEver RP, Shuman MA. PMID: 3479442.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    68. Detection of sickle cell anaemia and thalassaemias. Nature. 1987 Sep 24-30; 329(6137):293-4. Chehab FF, Doherty M, Cai SP, Kan YW, Cooper S, Rubin EM. PMID: 3627274.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    69. Application of DNA polymorphisms for prenatal diagnosis of beta thalassemia in Chinese. Am J Hematol. 1987 Aug; 25(4):409-15. Chan V, Chan TK, Ghosh A, Wong LC, Ma HK, Kan YW, Todd D. PMID: 2887108.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    70. Male-enhanced expression and genetic conservation of a gene isolated with an anti-H-Y antibody. Trans Assoc Am Physicians. 1987; 100:45-53. Lau YF, Chan KM, Kan YW, Goldberg E. PMID: 3455075.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    71. Characteristics and distribution of beta thalassemia haplotypes in South China. Hum Genet. 1986 May; 73(1):23-6. Chan V, Chan TK, Cheng MY, Leung NK, Kan YW, Todd D. PMID: 3011644.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    72. The William Allan Memorial Award address: Thalassemia: molecular mechanism and detection. Am J Hum Genet. 1986 Jan; 38(1):4-12. Kan YW. PMID: 3946420.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    73. A simple sensitive prenatal test for hydrops fetalis caused by alpha-thalassaemia. Lancet. 1985 Jan 12; 1(8420):75-7. Rubin EM, Kan YW. PMID: 2857027.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    74. Initiation codon mutation as a cause of alpha thalassemia. J Biol Chem. 1984 Oct 25; 259(20):12315-7. Pirastu M, Saglio G, Chang JC, Cao A, Kan YW. PMID: 6490612.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    75. BamH I polymorphism in the Chinese: its potential usefulness in prenatal diagnosis of beta thalassaemia. Br Med J (Clin Res Ed). 1984 Oct 13; 289(6450):947-8. Chan V, Leung NK, Chan TK, Ghosh A, Kan YW, Todd D. PMID: 6091839.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    76. A beta-thalassemia lesion abolishes the same Mst II site as the sickle mutation. Nucleic Acids Res. 1983 Nov 25; 11(22):7789-94. Chang JC, Alberti A, Kan YW. PMID: 6316272.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    77. Prenatal diagnosis of beta-thalassemia. Detection of a single nucleotide mutation in DNA. N Engl J Med. 1983 Aug 04; 309(5):284-7. Pirastu M, Kan YW, Cao A, Conner BJ, Teplitz RL, Wallace RB. PMID: 6866053.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    78. A sensitive new prenatal test for sickle-cell anemia. N Engl J Med. 1982 Jul 01; 307(1):30-2. Chang JC, Kan YW. PMID: 6176866.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    79. Antenatal diagnosis of sickle cell anemia by sensitive DNA assay. Lancet. 1982 Jun 26; 1(8287):1463. Chang JC, Golbus MS, Kan YW. PMID: 6123735.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    80. Concurrent sickle-cell anemia and alpha-thalassemia: effect on severity of anemia. N Engl J Med. 1982 Feb 04; 306(5):270-4. Embury SH, Dozy AM, Miller J, Davis JR, Kleman KM, Preisler H, Vichinsky E, Lande WN, Lubin BH, Kan YW, Mentzer WC. PMID: 6172710.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    81. A sensitive test for prenatal diagnosis of sickle cell anemia: direct analysis of amniocyte DNA with MstII. Trans Assoc Am Physicians. 1982; 95:71-8. Chang JC, Kan YW. PMID: 6304979.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    82. Prenatal diagnosis by DNA analysis. Birth Defects Orig Artic Ser. 1982; 18(7):275-83. Kan YW, Chang JC, Dozy AM. PMID: 6297633.
      View in: PubMed   Mentions:    Fields:    
    83. Assigning the polymorphic human insulin gene to the short arm of chromosome 11 by chromosome sorting. Hum Genet. 1982; 60(1):10-15. Lebo RV, Kan YW, Cheung MC, Carrano AV, Yu LC, Chang JC, Cordell B, Goodman HM. PMID: 6281170.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    84. Antenatal diagnosis of sickle cell anaemia by direct analysis of the sickle mutation. Lancet. 1981 Nov 21; 2(8256):1127-9. Chang JC, Kan YW. PMID: 6118575.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    85. beta zero thalassemia in Sardinia is caused by a nonsense mutation. J Clin Invest. 1981 Oct; 68(4):1012-7. Trecartin RF, Liebhaber SA, Chang JC, Lee KY, Kan YW, Furbetta M, Angius A, Cao A. PMID: 6457059.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    86. Polymorphism of DNA sequence in the beta-globin gene region. Application to prenatal diagnosis of beta 0 thalassemia in Sardinia. N Engl J Med. 1980 Jan 24; 302(4):185-8. Kan YW, Lee KY, Furbetta M, Angius A, Cao A. PMID: 6927915.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    87. Nonsense mutation as a cause of beta 0 thalassemia. Ann N Y Acad Sci. 1980; 344:113-9. Chang JC, Kan YW, Trecartin RF, Temple GF. PMID: 6985475.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    88. Prenatal diagnosis of hemoglobinopathies. Ann N Y Acad Sci. 1980; 344:141-50. Kan YW, Trecartin RF, Dozy AM. PMID: 6156622.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    89. Suppression of the nonsense mutation in homozygous beta 0 thalassaemia. Nature. 1979 Oct 18; 281(5732):602-3. Chang JC, Temple GF, Trecartin RF, Kan YW. PMID: 492326.
      View in: PubMed   Mentions: 13     Fields:    
    90. beta 0 thalassemia, a nonsense mutation in man. Proc Natl Acad Sci U S A. 1979 Jun; 76(6):2886-9. Chang JC, Kan YW. PMID: 88735.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansCells
    91. Prenatal diagnosis of homozygous alpha-thalassemia. JAMA. 1979 Apr 13; 241(15):1610-2. Dozy AM, Forman EN, Abuelo DN, Barsel-Bowers G, Mahoney MJ, Forget BG, Kan YW. PMID: 430715.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    92. The nucleotide sequence of the 5' untranslated region of human gamma-globin mRNA. Nucleic Acids Res. 1978 Oct; 5(10):3515-22. Chang JC, Poon R, Neumann KH, Kan YW. PMID: 318162.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    93. Diagnosis of homozygous alpha-thalassemia in cultured amniotic-fluid fibroblasts. N Engl J Med. 1978 Mar 23; 298(12):669-70. Wong V, Ma HK, Todd D, Golbus MS, Dozy AM, Kan YW. PMID: 628389.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    94. Prenatal diagnosis of hemoglobin H disease. J Pediatr. 1978 Feb; 92(2):278-81. Koenig HM, Vedvick TS, Dozy AM, Golbus MS, Kan YW. PMID: 74407.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    95. The nucleotide sequences of the untranslated 5' regions of human alpha- and beta-globin mRNAs. Proc Natl Acad Sci U S A. 1977 Nov; 74(11):5145-9. Chang JC, Temple GF, Poon R, Neumann KH, Kan YW. PMID: 270752.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    96. Authentic beta-globin mRNA sequences in homozygous betaO-thalassemia. Proc Natl Acad Sci U S A. 1977 Jul; 74(7):3047-51. Temple GF, Chang JC, Kan YW. PMID: 268654.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    97. Prenatal diagnosis of alpha-thalassemia. Clinical application of molecular hybridization. N Engl J Med. 1976 Nov 18; 295(21):1165-7. Kan YW, Golbus MS, Dozy AM. PMID: 980019.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    98. Relation of beta to gamma synthesis during the first trimester: an approach to prenatal diagnosis of thalassemia. Pediatr Res. 1974 May; 8(5):553-60. Cividalli G, Nathan DG, Kan YW, Santamarina B, Frigoletto F. PMID: 4825524.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
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