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    Carol Mathews, MD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentPsychiatry
    Address401 Parnassus Ave, LangPorter
    San Francisco CA 94143
    Phone415-476-7702
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      Collapse Biography 
      Collapse Education and Training
      John Hopkins UniversityM.D.School of Medicine1992

      Collapse Overview 
      Collapse Overview
      Research activities: My research is focused on how genes, environment, and culture interact to influence the development and expression of neuropsychiatric symptoms/syndromes, including anxiety, resilience, obsessive compulsive disorder (OCD), compulsive hoarding, tic disorders, including Tourette Syndrome (TS), and attention deficit hyperactivity disorder (ADHD). These disorders are common, usually begin in childhood, and are frequently co-morbid with one another. In addition, there is some evidence that they may have overlapping etiologies. One component of my research focuses on identifying susceptibility genes for OCD and TS using linkage analyses in genetically isolated populations and genome-wide association (GWAS) approaches. Another component focuses on identifying potential endophenotypes or intermediate phenotypes for these complex traits, using clinical, neuropsychological, electrophyisological and neuroimaging approaches. See my website for more details on a particular project. pgenes.net

      Clinical activities: Director, Obsessive Compulsive Disorders Clinic, UCSF, 2007-present. I direct and attend in this resident-staffed clinic, which meets for 1/2 day a week, and sees adults, adolescents, and children with OCD, Tourette Syndrome, and related disorders for consultation, evaluation, and treatment, including pharmacological treatment and psychotherapy, with a focus on cognitive behavioral therapy.

      Co-Director, Anxiety Disorders Program, UCSF, 2009. I co-direct and attend in this resident-staffed clinic, which meets for 1 and 1/2 days a week, and sees adults with Anxiety Disorders for consultation, evaluation, and treatment, including pharmacological treatment and psychotherapy, with a focus on cognitive behavioral therapy.

      Faculty practice, UCSF, 2006-current, two days a week. In my UCSF faculty practice, I see adults, adolescents, and children with OCD, Tourette Syndrome, and related disorders for consultation, evaluation, and treatment, including pharmacological treatment and psychotherapy, with a focus on cognitive behavioral therapy.

      Teaching/Mentoring: My mentoring activities are primarily focused in the area of mentoring psychiatry research residents, postdoctoral fellows, and junior faculty in the area of pursuing academic careers in research. I have been active as the co-director of the Psychiatry Resident Research Training Program (RRTP) since arriving at UCSF in 2006, and have recently been appointed as the Faculty Chief for Research and Scholarship for the Department of Psychiatry. In these roles, I have been very active in mentoring and promoting the research and academic careers of women and minorities within the Department. I have mentored approximately 20 residents, fellows, or faculty members since coming to UCSF. The RRTP, which I co-direct, has had a very successful record of recruiting and training both women (55% of RRTP residents are women) and ethnic minorities (over 30% of RRTP residents are ethnic minorities). I currently mentor two postdoctoral research fellows as well as a nursing graduate student in a research mentorship capacity, as well as many RRTP and general psychiatry residents as a faculty/career mentor. In addition, because of my involvement in several international research collaborations, I have had the opportunity to mentor/supervise a number of international students who have chosen to come to my laboratory for additional training and/or research rotations. These include a Master’s student from the Free University of Amsterdam, an undergraduate/medical student from the University of Cologne, and a psychiatrist from Buenos Aires, Argentina. I am also active in mentoring junior faculty through the UCSF Department of Psychiatry’s Faculty Mentorship Program. I currently mentor four junior faculty through this program; all are in the early stages of their research careers and are planning the next steps for ongoing successful academic careers.


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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Darrow SM, Verhoeven JE, Révész D, Lindqvist D, Penninx BW, Delucchi KL, Wolkowitz OM, Mathews CA. The Association Between Psychiatric Disorders and Telomere Length: A Meta-Analysis Involving 14,827 Persons. Psychosom Med. 2016 Sep; 78(7):776-87. PMID: 27359174; PMCID: PMC5003712 [Available on 09/01/17].
      2. Ordóñez AE, Ranney R, Schwartz M, Mathews CA, Satre DD. Hazardous drinking among young adults seeking outpatient mental health services. Addict Sci Clin Pract. 2016; 11(1):12. PMID: 27506832.
        View in: PubMed
      3. Georgitsi M, Willsey AJ, Mathews CA, State M, Scharf JM, Paschou P. The Genetic Etiology of Tourette Syndrome: Large-Scale Collaborative Efforts on the Precipice of Discovery. Front Neurosci. 2016; 10:351. PMID: 27536211.
        View in: PubMed
      4. Uhm SY, Tsoh JY, Mackin RS, Gause M, Chan J, Franklin J, Eckfield M, Salazar M, Vigil O, Bain D, Stark S, Vega E, Delucchi KL, Mathews CA, et al. Comparison of a peer facilitated support group to cognitive behavior therapy: Study protocol for a randomized controlled trial for hoarding disorder. Contemp Clin Trials. 2016 Jul 18. PMID: 27444427.
        View in: PubMed
      5. Hough CM, Luks TL, Lai K, Vigil O, Guillory S, Nongpiur A, Fekri SM, Kupferman E, Mathalon DH, Mathews CA. Comparison of brain activation patterns during executive function tasks in hoarding disorder and non-hoarding OCD. Psychiatry Res. 2016 Sep 30; 255:50-9. PMID: 27522332; PMCID: PMC5014569 [Available on 09/30/17].
      6. Hirschtritt ME, Darrow SM, Illmann C, Osiecki L, Grados M, Sandor P, Dion Y, King RA, Pauls DL, Budman CL, Cath DC, Greenberg E, Lyon GJ, Yu D, McGrath LM, McMahon WM, Lee PC, Delucchi KL, Scharf JM, Mathews CA. Social disinhibition is a heritable subphenotype of tics in Tourette syndrome. Neurology. 2016 Aug 2; 87(5):497-504. PMID: 27371487.
        View in: PubMed
      7. Mathews CA, Stern JS. The First World Congress on Tourette Syndrome and Tic Disorders: Controversies and Hot Topics in Etiology and Treatment. Front Neurosci. 2016; 10:246. PMID: 27375411.
        View in: PubMed
      8. Besterman AD, Williams JK, Reus VI, Pato MT, Voglmaier SM, Mathews CA. The Role of Regional Conferences in Research Resident Career Development: The California Psychiatry Research Resident Retreat. Acad Psychiatry. 2016 May 13. PMID: 27178277.
        View in: PubMed
      9. Huisman-van Dijk HM, Schoot Rv, Rijkeboer MM, Mathews CA, Cath DC. The relationship between tics, OC, ADHD and autism symptoms: A cross- disorder symptom analysis in Gilles de la Tourette syndrome patients and family-members. Psychiatry Res. 2016 Mar 30; 237:138-46. PMID: 26826899.
        View in: PubMed
      10. Mathews CA, Uhm S, Chan J, Gause M, Franklin J, Plumadore J, Stark SJ, Yu W, Vigil O, Salazar M, Delucchi KL, Vega E. Treating Hoarding Disorder in a real-world setting: Results from the Mental Health Association of San Francisco. Psychiatry Res. 2016 Mar 30; 237:331-8. PMID: 26805562.
        View in: PubMed
      11. Burton CL, Crosbie J, Dupuis A, Mathews CA, Soreni N, Schachar R, Arnold PD. Clinical Correlates of Hoarding With and Without Comorbid Obsessive-Compulsive Symptoms in a Community Pediatric Sample. J Am Acad Child Adolesc Psychiatry. 2016 Feb; 55(2):114-121.e2. PMID: 26802778.
        View in: PubMed
      12. Mackin RS, Vigil O, Insel P, Kivowitz A, Kupferman E, Hough CM, Fekri S, Crothers R, Bickford D, Delucchi KL, Mathews CA. PATTERNS OF CLINICALLY SIGNIFICANT COGNITIVE IMPAIRMENT IN HOARDING DISORDER. Depress Anxiety. 2016 Mar; 33(3):211-8. PMID: 26474146.
        View in: PubMed
      13. Mathews CA, Perez VB, Roach BJ, Fekri S, Vigil O, Kupferman E, Mathalon DH. Error-related brain activity dissociates hoarding disorder from obsessive-compulsive disorder. Psychol Med. 2016 Jan; 46(2):367-79. PMID: 26415671.
        View in: PubMed
      14. Tharp JA, Wendelken C, Mathews CA, Marco EJ, Schreier H, Bunge SA. Tourette Syndrome: Complementary Insights from Measures of Cognitive Control, Eyeblink Rate, and Pupil Diameter. Front Psychiatry. 2015; 6:95. PMID: 26175694; PMCID: PMC4484341.
      15. Hirschtritt ME, Lee PC, Pauls DL, Dion Y, Grados MA, Illmann C, King RA, Sandor P, McMahon WM, Lyon GJ, Cath DC, Kurlan R, Robertson MM, Osiecki L, Scharf JM, Mathews CA. Lifetime prevalence, age of risk, and genetic relationships of comorbid psychiatric disorders in Tourette syndrome. JAMA Psychiatry. 2015 Apr; 72(4):325-33. PMID: 25671412; PMCID: PMC4446055.
      16. Gist L, Mathews C, Williams KN, Stein MT. A 9-year-old girl with persistent obsessive and compulsive behaviors in a primary care pediatric practice. J Dev Behav Pediatr. 2015 Apr; 36(3):203-6. PMID: 25790298.
        View in: PubMed
      17. de Leeuw C, Goudriaan A, Smit AB, Yu D, Mathews CA, Scharf JM, Verheijen MH, Posthuma D. Involvement of astrocyte metabolic coupling in Tourette syndrome pathogenesis. Eur J Hum Genet. 2015 Oct; 23(11):1519-22. PMID: 25735483; PMCID: PMC4613465 [Available on 10/01/16].
      18. Scharf JM, Miller LL, Gauvin CA, Alabiso J, Mathews CA, Ben-Shlomo Y. Population prevalence of Tourette syndrome: a systematic review and meta-analysis. Mov Disord. 2015 Feb; 30(2):221-8. PMID: 25487709.
        View in: PubMed
      19. Yu D, Mathews CA, Scharf JM, Neale BM, Davis LK, Gamazon ER, Derks EM, Evans P, Edlund CK, Crane J, Fagerness JA, Osiecki L, Gallagher P, Gerber G, Haddad S, Illmann C, McGrath LM, Mayerfeld C, Arepalli S, Barlassina C, Barr CL, Bellodi L, Benarroch F, Berrió GB, Bienvenu OJ, Black DW, Bloch MH, Brentani H, Bruun RD, Budman CL, Camarena B, Campbell DD, Cappi C, Silgado JC, Cavallini MC, Chavira DA, Chouinard S, Cook EH, Cookson MR, Coric V, Cullen B, Cusi D, Delorme R, Denys D, Dion Y, Eapen V, Egberts K, Falkai P, Fernandez T, Fournier E, Garrido H, Geller D, Gilbert DL, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Hardy J, Heiman GA, Hemmings SM, Herrera LD, Hezel DM, Hoekstra PJ, Jankovic J, Kennedy JL, King RA, Konkashbaev AI, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Lupoli S, Macciardi F, Maier W, Manunta P, Marconi M, McCracken JT, Mesa Restrepo SC, Moessner R, Moorjani P, Morgan J, Muller H, Murphy DL, Naarden AL, Nurmi E, Ochoa WC, Ophoff RA, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Rauch SL, Renner T, Reus VI, Richter MA, Riddle MA, Robertson MM, Romero R, Rosário MC, Rosenberg D, Ruhrmann S, Sabatti C, Salvi E, Sampaio AS, Samuels J, Sandor P, Service SK, Sheppard B, Singer HS, Smit JH, Stein DJ, Strengman E, Tischfield JA, Turiel M, Valencia Duarte AV, Vallada H, Veenstra-VanderWeele J, Walitza S, Wang Y, Weale M, Weiss R, Wendland JR, Westenberg HG, Shugart YY, Hounie AG, Miguel EC, Nicolini H, Wagner M, Ruiz-Linares A, Cath DC, McMahon W, Posthuma D, Oostra BA, Nestadt G, Rouleau GA, Purcell S, Jenike MA, Heutink P, Hanna GL, Conti DV, Arnold PD, Freimer NB, Stewart SE, Knowles JA, Cox NJ, Pauls DL. Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD. Am J Psychiatry. 2015 Jan; 172(1):82-93. PMID: 25158072; PMCID: PMC4282594 [Available on 01/01/16].
      20. Pauls DL, Fernandez TV, Mathews CA, State MW, Scharf JM. The Inheritance of Tourette Disorder: A review. J Obsessive Compuls Relat Disord. 2014 Oct 1; 3(4):380-385. PMID: 25506544.
        View in: PubMed
      21. Cachay E, Agmas W, Mathews C. Five-year cumulative incidence of invasive anal cancer among HIV-infected patients according to baseline anal cytology results: an inception cohort analysis. HIV Med. 2015 Mar; 16(3):191-5. PMID: 25197003; PMCID: PMC4320654.
      22. Mathews CA. Hoarding disorder: more than just a problem of too much stuff. J Clin Psychiatry. 2014 Aug; 75(8):893-4. PMID: 25191909; PMCID: PMC4432907.
      23. Paschou P, Yu D, Gerber G, Evans P, Tsetsos F, Davis LK, Karagiannidis I, Chaponis J, Gamazon E, Mueller-Vahl K, Stuhrmann M, Schloegelhofer M, Stamenkovic M, Hebebrand J, Noethen M, Nagy P, Barta C, Tarnok Z, Rizzo R, Depienne C, Worbe Y, Hartmann A, Cath DC, Budman CL, Sandor P, Barr C, Wolanczyk T, Singer H, Chou IC, Grados M, Posthuma D, Rouleau GA, Aschauer H, Freimer NB, Pauls DL, Cox NJ, Mathews CA, Scharf JM. Genetic association signal near NTN4 in Tourette syndrome. Ann Neurol. 2014 Aug; 76(2):310-5. PMID: 25042818; PMCID: PMC4140987.
      24. McGrath LM, Yu D, Marshall C, Davis LK, Thiruvahindrapuram B, Li B, Cappi C, Gerber G, Wolf A, Schroeder FA, Osiecki L, O'Dushlaine C, Kirby A, Illmann C, Haddad S, Gallagher P, Fagerness JA, Barr CL, Bellodi L, Benarroch F, Bienvenu OJ, Black DW, Bloch MH, Bruun RD, Budman CL, Camarena B, Cath DC, Cavallini MC, Chouinard S, Coric V, Cullen B, Delorme R, Denys D, Derks EM, Dion Y, Rosário MC, Eapen V, Evans P, Falkai P, Fernandez TV, Garrido H, Geller D, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Heiman GA, Hemmings SM, Herrera LD, Hounie AG, Jankovic J, Kennedy JL, King RA, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Lochner C, Lowe TL, Lyon GJ, Macciardi F, Maier W, McCracken JT, McMahon W, Murphy DL, Naarden AL, Neale BM, Nurmi E, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Reus VI, Richter MA, Riddle M, Robertson MM, Rosenberg D, Rouleau GA, Ruhrmann S, Sampaio AS, Samuels J, Sandor P, Sheppard B, Singer HS, Smit JH, Stein DJ, Tischfield JA, Vallada H, Veenstra-VanderWeele J, Walitza S, Wang Y, Wendland JR, Shugart YY, Miguel EC, Nicolini H, Oostra BA, Moessner R, Wagner M, Ruiz-Linares A, Heutink P, Nestadt G, Freimer N, Petryshen T, Posthuma D, Jenike MA, Cox NJ, Hanna GL, Brentani H, Scherer SW, Arnold PD, Stewart SE, Mathews CA, Knowles JA, Cook EH, Pauls DL, Wang K, Scharf JM. Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study. J Am Acad Child Adolesc Psychiatry. 2014 Aug; 53(8):910-9. PMID: 25062598; PMCID: PMC4218748.
      25. Teo AR, Fetters MD, Stufflebam K, Tateno M, Balhara Y, Choi TY, Kanba S, Mathews CA, Kato TA. Identification of the hikikomori syndrome of social withdrawal: Psychosocial features and treatment preferences in four countries. Int J Soc Psychiatry. 2015 Feb; 61(1):64-72. PMID: 24869848.
        View in: PubMed
      26. Mathews CA, Delucchi K, Cath DC, Willemsen G, Boomsma DI. Partitioning the etiology of hoarding and obsessive-compulsive symptoms. Psychol Med. 2014 Oct; 44(13):2867-76. PMID: 25066062; PMCID: PMC4429876.
      27. Mathews CA, Scharf JM, Miller LL, Macdonald-Wallis C, Lawlor DA, Ben-Shlomo Y. Association between pre- and perinatal exposures and Tourette syndrome or chronic tic disorder in the ALSPAC cohort. Br J Psychiatry. 2014 Jan; 204(1):40-5. PMID: 24262815; PMCID: PMC3877832.
      28. Davis LK, Yu D, Keenan CL, Gamazon ER, Konkashbaev AI, Derks EM, Neale BM, Yang J, Lee SH, Evans P, Barr CL, Bellodi L, Benarroch F, Berrio GB, Bienvenu OJ, Bloch MH, Blom RM, Bruun RD, Budman CL, Camarena B, Campbell D, Cappi C, Cardona Silgado JC, Cath DC, Cavallini MC, Chavira DA, Chouinard S, Conti DV, Cook EH, Coric V, Cullen BA, Deforce D, Delorme R, Dion Y, Edlund CK, Egberts K, Falkai P, Fernandez TV, Gallagher PJ, Garrido H, Geller D, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Haddad S, Heiman GA, Hemmings SM, Hounie AG, Illmann C, Jankovic J, Jenike MA, Kennedy JL, King RA, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Macciardi F, McCracken JT, McGrath LM, Mesa Restrepo SC, Moessner R, Morgan J, Muller H, Murphy DL, Naarden AL, Ochoa WC, Ophoff RA, Osiecki L, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Rauch SL, Renner TJ, Reus VI, Richter MA, Riddle MA, Robertson MM, Romero R, Rosàrio MC, Rosenberg D, Rouleau GA, Ruhrmann S, Ruiz-Linares A, Sampaio AS, Samuels J, Sandor P, Sheppard B, Singer HS, Smit JH, Stein DJ, Strengman E, Tischfield JA, Valencia Duarte AV, Vallada H, Van Nieuwerburgh F, Veenstra-Vanderweele J, Walitza S, Wang Y, Wendland JR, Westenberg HG, Shugart YY, Miguel EC, McMahon W, Wagner M, Nicolini H, Posthuma D, Hanna GL, Heutink P, Denys D, Arnold PD, Oostra BA, Nestadt G, Freimer NB, Pauls DL, Wray NR, Stewart SE, Mathews CA, Knowles JA, Cox NJ, Scharf JM. Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet. 2013 Oct; 9(10):e1003864. PMID: 24204291; PMCID: PMC3812053.
      29. Miller LL, Scharf JM, Mathews CA, Ben-Shlomo Y. Tourette syndrome and chronic tic disorder are associated with lower socio-economic status: findings from the Avon Longitudinal Study of Parents and Children cohort. Dev Med Child Neurol. 2014 Feb; 56(2):157-63. PMID: 24138188; PMCID: PMC3908357.
      30. Tsai AC, Ordóñez AE, Reus VI, Mathews CA. Eleven-year outcomes from an integrated residency program to train research psychiatrists. Acad Med. 2013 Jul; 88(7):983-8. PMID: 23702520; PMCID: PMC3713635.
      31. Stewart SE, Mayerfeld C, Arnold PD, Crane JR, O'Dushlaine C, Fagerness JA, Yu D, Scharf JM, Chan E, Kassam F, Moya PR, Wendland JR, Delorme R, Richter MA, Kennedy JL, Veenstra-VanderWeele J, Samuels J, Greenberg BD, McCracken JT, Knowles JA, Fyer AJ, Rauch SL, Riddle MA, Grados MA, Bienvenu OJ, Cullen B, Wang Y, Shugart YY, Piacentini J, Rasmussen S, Nestadt G, Murphy DL, Jenike MA, Cook EH, Pauls DL, Hanna GL, Mathews CA. Meta-analysis of association between obsessive-compulsive disorder and the 3' region of neuronal glutamate transporter gene SLC1A1. Am J Med Genet B Neuropsychiatr Genet. 2013 Jun; 162B(4):367-79. PMID: 23606572.
        View in: PubMed
      32. Nag A, Bochukova EG, Kremeyer B, Campbell DD, Muller H, Valencia-Duarte AV, Cardona J, Rivas IC, Mesa SC, Cuartas M, Garcia J, Bedoya G, Cornejo W, Herrera LD, Romero R, Fournier E, Reus VI, Lowe TL, Farooqi IS, Mathews CA, McGrath LM, Yu D, Cook E, Wang K, Scharf JM, Pauls DL, Freimer NB, Plagnol V, Ruiz-Linares A. CNV analysis in Tourette syndrome implicates large genomic rearrangements in COL8A1 and NRXN1. PLoS One. 2013; 8(3):e59061. PMID: 23533600; PMCID: PMC3606459.
      33. Egan CA, Marakovitz SE, O'Rourke JA, Osiecki L, Illmann C, Barton L, McLaughlin E, Proujansky R, Royal J, Cowley H, Rangel-Lugo M, Pauls DL, Scharf JM, Mathews CA. Effectiveness of a web-based protocol for the screening and phenotyping of individuals with Tourette syndrome for genetic studies. Am J Med Genet B Neuropsychiatr Genet. 2012 Dec; 159B(8):987-96. PMID: 23090870; PMCID: PMC3903004.
      34. Chen K, Budman CL, Diego Herrera L, Witkin JE, Weiss NT, Lowe TL, Freimer NB, Reus VI, Mathews CA. Prevalence and clinical correlates of explosive outbursts in Tourette syndrome. Psychiatry Res. 2013 Feb 28; 205(3):269-75. PMID: 23040794; PMCID: PMC3543492.
      35. Scharf JM, Yu D, Mathews CA, Neale BM, Stewart SE, Fagerness JA, Evans P, Gamazon E, Edlund CK, Service SK, Tikhomirov A, Osiecki L, Illmann C, Pluzhnikov A, Konkashbaev A, Davis LK, Han B, Crane J, Moorjani P, Crenshaw AT, Parkin MA, Reus VI, Lowe TL, Rangel-Lugo M, Chouinard S, Dion Y, Girard S, Cath DC, Smit JH, King RA, Fernandez TV, Leckman JF, Kidd KK, Kidd JR, Pakstis AJ, State MW, Herrera LD, Romero R, Fournier E, Sandor P, Barr CL, Phan N, Gross-Tsur V, Benarroch F, Pollak Y, Budman CL, Bruun RD, Erenberg G, Naarden AL, Lee PC, Weiss N, Kremeyer B, Berrío GB, Campbell DD, Cardona Silgado JC, Ochoa WC, Mesa Restrepo SC, Muller H, Valencia Duarte AV, Lyon GJ, Leppert M, Morgan J, Weiss R, Grados MA, Anderson K, Davarya S, Singer H, Walkup J, Jankovic J, Tischfield JA, Heiman GA, Gilbert DL, Hoekstra PJ, Robertson MM, Kurlan R, Liu C, Gibbs JR, Singleton A, Hardy J, Strengman E, Ophoff RA, Wagner M, Moessner R, Mirel DB, Posthuma D, Sabatti C, Eskin E, Conti DV, Knowles JA, Ruiz-Linares A, Rouleau GA, Purcell S, Heutink P, Oostra BA, McMahon WM, Freimer NB, Cox NJ, Pauls DL. Genome-wide association study of Tourette's syndrome. Mol Psychiatry. 2013 Jun; 18(6):721-8. PMID: 22889924; PMCID: PMC3605224.
      36. Stewart SE, Yu D, Scharf JM, Neale BM, Fagerness JA, Mathews CA, Arnold PD, Evans PD, Gamazon ER, Davis LK, Osiecki L, McGrath L, Haddad S, Crane J, Hezel D, Illman C, Mayerfeld C, Konkashbaev A, Liu C, Pluzhnikov A, Tikhomirov A, Edlund CK, Rauch SL, Moessner R, Falkai P, Maier W, Ruhrmann S, Grabe HJ, Lennertz L, Wagner M, Bellodi L, Cavallini MC, Richter MA, Cook EH, Kennedy JL, Rosenberg D, Stein DJ, Hemmings SM, Lochner C, Azzam A, Chavira DA, Fournier E, Garrido H, Sheppard B, Umaña P, Murphy DL, Wendland JR, Veenstra-VanderWeele J, Denys D, Blom R, Deforce D, Van Nieuwerburgh F, Westenberg HG, Walitza S, Egberts K, Renner T, Miguel EC, Cappi C, Hounie AG, Conceição do Rosário M, Sampaio AS, Vallada H, Nicolini H, Lanzagorta N, Camarena B, Delorme R, Leboyer M, Pato CN, Pato MT, Voyiaziakis E, Heutink P, Cath DC, Posthuma D, Smit JH, Samuels J, Bienvenu OJ, Cullen B, Fyer AJ, Grados MA, Greenberg BD, McCracken JT, Riddle MA, Wang Y, Coric V, Leckman JF, Bloch M, Pittenger C, Eapen V, Black DW, Ophoff RA, Strengman E, Cusi D, Turiel M, Frau F, Macciardi F, Gibbs JR, Cookson MR, Singleton A, Hardy J, Crenshaw AT, Parkin MA, Mirel DB, Conti DV, Purcell S, Nestadt G, Hanna GL, Jenike MA, Knowles JA, Cox N, Pauls DL. Genome-wide association study of obsessive-compulsive disorder. Mol Psychiatry. 2013 Jul; 18(7):788-98. PMID: 22889921; PMCID: PMC4218751.
      37. Mathews CA, Badner JA, Andresen JM, Sheppard B, Himle JA, Grant JE, Williams KA, Chavira DA, Azzam A, Schwartz M, Reus VI, Kim SW, Cook EH, Hanna GL. Genome-wide linkage analysis of obsessive-compulsive disorder implicates chromosome 1p36. Biol Psychiatry. 2012 Oct 15; 72(8):629-36. PMID: 22633946; PMCID: PMC3437244.
      38. Mathews CA, Perez VB, Delucchi KL, Mathalon DH. Error-related negativity in individuals with obsessive-compulsive symptoms: toward an understanding of hoarding behaviors. Biol Psychol. 2012 Feb; 89(2):487-94. PMID: 22227169; PMCID: PMC3292435.
      39. Scharf JM, Miller LL, Mathews CA, Ben-Shlomo Y. Prevalence of Tourette syndrome and chronic tics in the population-based Avon longitudinal study of parents and children cohort. J Am Acad Child Adolesc Psychiatry. 2012 Feb; 51(2):192-201.e5. PMID: 22265365; PMCID: PMC3314954.
      40. Berrocal M, Peskin V, Weiss N, Schuler J, Monge S, McGough JJ, Chavira D, Bagnarello M, Herrera LD, Mathews CA. [Prevalence of and screening for ADHD in Costa Rica]. Vertex. 2011 Sep-Oct; 22(99):337-42. PMID: 22432094; PMCID: PMC4431996.
      41. Ross J, Badner J, Garrido H, Sheppard B, Chavira DA, Grados M, Woo JM, Doo P, Umaña P, Fournier E, Murray SS, Mathews CA. Genomewide linkage analysis in Costa Rican families implicates chromosome 15q14 as a candidate region for OCD. Hum Genet. 2011 Dec; 130(6):795-805. PMID: 21691774; PMCID: PMC4442699.
      42. Schuler J, Weiss NT, Chavira DA, McGough JJ, Berrocal M, Sheppard B, Vaglio E, Fournier E, Herrera LD, Mathews CA. Characteristics and comorbidity of ADHD sib pairs in the Central Valley of Costa Rica. Compr Psychiatry. 2012 May; 53(4):379-86. PMID: 21696714; PMCID: PMC3179797.
      43. Wang Y, Mathews CA, Li Y, Lin Z, Xiao Z. Brain-derived neurotrophic factor (BDNF) plasma levels in drug-naïve OCD patients are lower than those in healthy people, but are not lower than those in drug-treated OCD patients. J Affect Disord. 2011 Sep; 133(1-2):305-10. PMID: 21616543.
        View in: PubMed
      44. Mackin RS, Areán PA, Delucchi KL, Mathews CA. Cognitive functioning in individuals with severe compulsive hoarding behaviors and late life depression. Int J Geriatr Psychiatry. 2011 Mar; 26(3):314-21. PMID: 21319334; PMCID: PMC4431997.
      45. Mathews CA, Grados MA. Familiality of Tourette syndrome, obsessive-compulsive disorder, and attention-deficit/hyperactivity disorder: heritability analysis in a large sib-pair sample. J Am Acad Child Adolesc Psychiatry. 2011 Jan; 50(1):46-54. PMID: 21156269; PMCID: PMC3035426.
      46. Delucchi KL, Katerberg H, Stewart SE, Denys DA, Lochner C, Stack DE, den Boer JA, van Balkom AJ, Jenike MA, Stein DJ, Cath DC, Mathews CA. Latent class analysis of the Yale-Brown Obsessive-Compulsive Scale symptoms in obsessive-compulsive disorder. Compr Psychiatry. 2011 May-Jun; 52(3):334-41. PMID: 21145539; PMCID: PMC3086656.
      47. Sheppard B, Chavira D, Azzam A, Grados MA, Umaña P, Garrido H, Mathews CA. ADHD prevalence and association with hoarding behaviors in childhood-onset OCD. Depress Anxiety. 2010 Jul; 27(7):667-74. PMID: 20583294; PMCID: PMC2925836.
      48. Scharf JM, Mathews CA. Copy number variation in Tourette syndrome: another case of neurodevelopmental generalist genes? Neurology. 2010 May 18; 74(20):1564-5. PMID: 20427746.
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      49. Katerberg H, Delucchi KL, Stewart SE, Lochner C, Denys DA, Stack DE, Andresen JM, Grant JE, Kim SW, Williams KA, den Boer JA, van Balkom AJ, Smit JH, van Oppen P, Polman A, Jenike MA, Stein DJ, Mathews CA, Cath DC. Symptom dimensions in OCD: item-level factor analysis and heritability estimates. Behav Genet. 2010 Jul; 40(4):505-17. PMID: 20361247; PMCID: PMC2886912.
      50. Knight S, Coon H, Johnson M, Leppert MF, Camp NJ, McMahon WM. Linkage analysis of Tourette syndrome in a large Utah pedigree. Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 5; 153B(2):656-62. PMID: 19777563; PMCID: PMC2923637.
      51. Grados MA, Mathews CA. Clinical phenomenology and phenotype variability in Tourette syndrome. J Psychosom Res. 2009 Dec; 67(6):491-6. PMID: 19913653.
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      52. Jasinska AJ, Service S, Jawaheer D, DeYoung J, Levinson M, Zhang Z, Kremeyer B, Muller H, Aldana I, Garcia J, Restrepo G, Lopez C, Palacio C, Duque C, Parra M, Vega J, Ortiz D, Bedoya G, Mathews C, Davanzo P, Fournier E, Bejarano J, Ramirez M, Araya Ortiz C, Araya X, Molina J, Sabatti C, Reus V, Ospina J, Macaya G, Ruiz-Linares A, Freimer NB. A narrow and highly significant linkage signal for severe bipolar disorder in the chromosome 5q33 region in Latin American pedigrees. Am J Med Genet B Neuropsychiatr Genet. 2009 Oct 5; 150B(7):998-1006. PMID: 19319892.
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      53. Mathews CA, Greenwood T, Wessel J, Azzam A, Garrido H, Chavira DA, Chandavarkar U, Bagnarello M, Stein M, Schork NJ. Evidence for a heritable unidimensional symptom factor underlying obsessionality. Am J Med Genet B Neuropsychiatr Genet. 2008 Sep 5; 147B(6):676-85. PMID: 18163383.
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      54. Grados MA, Mathews CA. Latent class analysis of gilles de la tourette syndrome using comorbidities: clinical and genetic implications. Biol Psychiatry. 2008 Aug 1; 64(3):219-25. PMID: 18359008; PMCID: PMC2596958.
      55. Mathews CA, Kaur N, Stein MB. Childhood trauma and obsessive-compulsive symptoms. Depress Anxiety. 2008; 25(9):742-51. PMID: 17557315.
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      56. Chavira DA, Garrido H, Bagnarello M, Azzam A, Reus VI, Mathews CA. A comparative study of obsessive-compulsive disorder in Costa Rica and the United States. Depress Anxiety. 2008; 25(7):609-19. PMID: 17823962.
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      57. Mathews CA, Nievergelt CM, Azzam A, Garrido H, Chavira DA, Wessel J, Bagnarello M, Reus VI, Schork NJ. Heritability and clinical features of multigenerational families with obsessive-compulsive disorder and hoarding. Am J Med Genet B Neuropsychiatr Genet. 2007 Mar 5; 144B(2):174-82. PMID: 17290446.
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      58. Chandavarkar U, Azzam A, Mathews CA. Anxiety symptoms and perceived performance in medical students. Depress Anxiety. 2007; 24(2):103-11. PMID: 16845642.
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      59. Keen-Kim D, Mathews CA, Reus VI, Lowe TL, Herrera LD, Budman CL, Gross-Tsur V, Pulver AE, Bruun RD, Erenberg G, Naarden A, Sabatti C, Freimer NB. Overrepresentation of rare variants in a specific ethnic group may confuse interpretation of association analyses. Hum Mol Genet. 2006 Nov 15; 15(22):3324-8. PMID: 17035247.
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      60. Herzberg I, Jasinska A, García J, Jawaheer D, Service S, Kremeyer B, Duque C, Parra MV, Vega J, Ortiz D, Carvajal L, Polanco G, Restrepo GJ, López C, Palacio C, Levinson M, Aldana I, Mathews C, Davanzo P, Molina J, Fournier E, Bejarano J, Ramírez M, Ortiz CA, Araya X, Sabatti C, Reus V, Macaya G, Bedoya G, Ospina J, Freimer N, Ruiz-Linares A. Convergent linkage evidence from two Latin-American population isolates supports the presence of a susceptibility locus for bipolar disorder in 5q31-34. Hum Mol Genet. 2006 Nov 1; 15(21):3146-53. PMID: 16984960.
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      61. Service S, Molina J, Deyoung J, Jawaheer D, Aldana I, Vu T, Araya C, Araya X, Bejarano J, Fournier E, Ramirez M, Mathews CA, Davanzo P, Macaya G, Sandkuijl L, Sabatti C, Reus V, Freimer N. Results of a SNP genome screen in a large Costa Rican pedigree segregating for severe bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2006 Jun 5; 141B(4):367-73. PMID: 16652356.
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      62. Mathews CA, Bimson B, Lowe TL, Herrera LD, Budman CL, Erenberg G, Naarden A, Bruun RD, Freimer NB, Reus VI. Association between maternal smoking and increased symptom severity in Tourette's syndrome. Am J Psychiatry. 2006 Jun; 163(6):1066-73. PMID: 16741208.
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      63. Mathews CA, Jang KL, Herrera LD, Lowe TL, Budman CL, Erenberg G, Naarden A, Bruun RD, Schork NJ, Freimer NB, Reus VI. Tic symptom profiles in subjects with Tourette Syndrome from two genetically isolated populations. Biol Psychiatry. 2007 Feb 1; 61(3):292-300. PMID: 16581034.
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      64. Abelson JF, Kwan KY, O'Roak BJ, Baek DY, Stillman AA, Morgan TM, Mathews CA, Pauls DL, Rasin MR, Gunel M, Davis NR, Ercan-Sencicek AG, Guez DH, Spertus JA, Leckman JF, Dure LS, Kurlan R, Singer HS, Gilbert DL, Farhi A, Louvi A, Lifton RP, Sestan N, State MW. Sequence variants in SLITRK1 are associated with Tourette's syndrome. Science. 2005 Oct 14; 310(5746):317-20. PMID: 16224024.
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      65. Mathews CA, Waller J, Glidden D, Lowe TL, Herrera LD, Budman CL, Erenberg G, Naarden A, Bruun RD, Freimer NB, Reus VI. Self injurious behaviour in Tourette syndrome: correlates with impulsivity and impulse control. J Neurol Neurosurg Psychiatry. 2004 Aug; 75(8):1149-55. PMID: 15258218; PMCID: PMC1739182.
      66. Mathews CA, Reus VI, Bejarano J, Escamilla MA, Fournier E, Herrera LD, Lowe TL, McInnes LA, Molina J, Ophoff RA, Raventos H, Sandkuijl LA, Service SK, Spesny M, León PE, Freimer NB. Genetic studies of neuropsychiatric disorders in Costa Rica: a model for the use of isolated populations. Psychiatr Genet. 2004 Mar; 14(1):13-23. PMID: 15091311.
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      67. Mathews CA, Jang KL, Hami S, Stein MB. The structure of obsessionality among young adults. Depress Anxiety. 2004; 20(2):77-85. PMID: 15468097.
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      68. Mathews CA, Reus VI. Genetic linkage in bipolar disorder. CNS Spectr. 2003 Dec; 8(12):891-904. PMID: 14978466.
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      69. Azzam A, Mathews CA. Meta-analysis of the association between the catecholamine-O-methyl-transferase gene and obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet. 2003 Nov 15; 123B(1):64-9. PMID: 14582147.
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      70. Verkerk AJ, Mathews CA, Joosse M, Eussen BH, Heutink P, Oostra BA. CNTNAP2 is disrupted in a family with Gilles de la Tourette syndrome and obsessive compulsive disorder. Genomics. 2003 Jul; 82(1):1-9. PMID: 12809671.
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      71. Escamilla MA, Batki S, Reus VI, Spesny M, Molina J, Service S, Vinogradov S, Neylan T, Mathews C, Meza L, Gallegos A, Montero AP, Cruz ML, Neuhaus J, Roche E, Smith L, Leon P, Freimer NB. Comorbidity of bipolar disorder and substance abuse in Costa Rica: pedigree- and population-based studies. J Affect Disord. 2002 Sep; 71(1-3):71-83. PMID: 12167503.
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      72. Ophoff RA, Escamilla MA, Service SK, Spesny M, Meshi DB, Poon W, Molina J, Fournier E, Gallegos A, Mathews C, Neylan T, Batki SL, Roche E, Ramirez M, Silva S, De Mille MC, Dong P, Leon PE, Reus VI, Sandkuijl LA, Freimer NB. Genomewide linkage disequilibrium mapping of severe bipolar disorder in a population isolate. Am J Hum Genet. 2002 Sep; 71(3):565-74. PMID: 12119601; PMCID: PMC379193.
      73. Mathews CA, Glidden D, Murray S, Forster P, Hargreaves WA. The effect on treatment outcomes of assigning patients to ethnically focused inpatient psychiatric units. Psychiatr Serv. 2002 Jul; 53(7):830-5. PMID: 12096165.
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      74. Mathews CA, Glidden D, Hargreaves WA. The effect on diagnostic rates of assigning patients to ethnically focused inpatient psychiatric units. Psychiatr Serv. 2002 Jul; 53(7):823-9. PMID: 12096164.
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      75. McInnes LA, Service SK, Reus VI, Barnes G, Charlat O, Jawahar S, Lewitzky S, Yang Q, Duong Q, Spesny M, Araya C, Araya X, Gallegos A, Meza L, Molina J, Ramirez R, Mendez R, Silva S, Fournier E, Batki SL, Mathews CA, Neylan T, Glatt CE, Escamilla MA, Luo D, Gajiwala P, Song T, Crook S, Nguyen JB, Roche E, Meyer JM, Leon P, Sandkuijl LA, Freimer NB, Chen H. Fine-scale mapping of a locus for severe bipolar mood disorder on chromosome 18p11.3 in the Costa Rican population. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11485-90. PMID: 11572994; PMCID: PMC58756.
      76. DenBesten PK, Machule D, Gallagher R, Marshall GW, Mathews C, Filvaroff E. The effect of TGF-beta 2 on dentin apposition and hardness in transgenic mice. Adv Dent Res. 2001 Aug; 15:39-41. PMID: 12640737.
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      77. Mathews CA, Reus VI. Assortative mating in the affective disorders: a systematic review and meta-analysis. Compr Psychiatry. 2001 Jul-Aug; 42(4):257-62. PMID: 11458299.
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      78. Mathews CA, Herrera Amighetti LD, Lowe TL, van de Wetering BJ, Freimer NB, Reus VI. Cultural influences on diagnosis and perception of Tourette syndrome in Costa Rica. J Am Acad Child Adolesc Psychiatry. 2001 Apr; 40(4):456-63. PMID: 11314572.
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      79. Loane MA, Bloomer SE, Corbett R, Eedy DJ, Evans C, Hicks N, Jacklin P, Lotery HE, Mathews C, Paisley J, Reid P, Steele K, Wootton R. A randomized controlled trial assessing the health economics of realtime teledermatology compared with conventional care: an urban versus rural perspective. J Telemed Telecare. 2001; 7(2):108-18. PMID: 11331049.
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      80. Wootton R, Bloomer SE, Corbett R, Eedy DJ, Hicks N, Lotery HE, Mathews C, Paisley J, Steele K, Loane MA. Multicentre randomised control trial comparing real time teledermatology with conventional outpatient dermatological care: societal cost-benefit analysis. BMJ. 2000 May 6; 320(7244):1252-6. PMID: 10797038; PMCID: PMC27370.
      81. Loane MA, Bloomer SE, Corbett R, Eedy DJ, Hicks N, Lotery HE, Mathews C, Paisley J, Steele K, Wootton R. A randomized controlled trial to assess the clinical effectiveness of both realtime and store-and-forward teledermatology compared with conventional care. J Telemed Telecare. 2000; 6 Suppl 1:S1-3. PMID: 10793956.
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      82. Loane MA, Bloomer SE, Corbett R, Eedy DJ, Gore HE, Hicks N, Mathews C, Paisley J, Steele K, Wootton R. Patient cost-benefit analysis of teledermatology measured in a randomized control trial. J Telemed Telecare. 1999; 5 Suppl 1:S1-3. PMID: 10534821.
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      83. Loane MA, Bloomer SE, Corbett R, Eedy DJ, Gore HE, Mathews C, Steele K, Wootton R. Patient satisfaction with realtime teledermatology in Northern Ireland. J Telemed Telecare. 1998; 4(1):36-40. PMID: 9640708.
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      84. Loane MA, Gore HE, Bloomer SE, Corbett R, Eedy DJ, Mathews C, Steele K, Wootton R. Preliminary results from the Northern Ireland arms of the UK Multicentre Teledermatology Trial: is clinical management by realtime teledermatology possible? J Telemed Telecare. 1998; 4 Suppl 1:3-5. PMID: 9640716.
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      85. Loane MA, Corbett R, Bloomer SE, Eedy DJ, Gore HE, Mathews C, Steele K, Wootton R. Diagnostic accuracy and clinical management by realtime teledermatology. Results from the Northern Ireland arms of the UK Multicentre Teledermatology Trial. J Telemed Telecare. 1998; 4(2):95-100. PMID: 9744165.
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      86. Loane MA, Gore HE, Corbett R, Steele K, Mathews C, Bloomer SE, Eedy DJ, Telford RW, Wootton R. Preliminary results from the Northern Ireland arms of the UK Multicentre Teledermatology Trial: effect of camera performance on diagnostic accuracy. J Telemed Telecare. 1997; 3 Suppl 1:73-5. PMID: 9218392.
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      87. Seibert FS, Tabcharani JA, Chang XB, Dulhanty AM, Mathews C, Hanrahan JW, Riordan JR. cAMP-dependent protein kinase-mediated phosphorylation of cystic fibrosis transmembrane conductance regulator residue Ser-753 and its role in channel activation. J Biol Chem. 1995 Feb 3; 270(5):2158-62. PMID: 7530719.
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      88. Mathews CA, George P, Hood AF. Cardiofaciocutaneous syndrome. Arch Dermatol. 1993 Jan; 129(1):46-7. PMID: 8420490.
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