Daniel Cooke, MD

TitleAssistant Professor
SchoolUCSF School of Medicine
Address1001 Potrero Ave
San Francisco CA 94110
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoClinical Fellowship Radiology
    Collapse Awards and Honors
    University of Washington2009Neuroradiology Research Award
    ACR Reeder2008Goldberg International Grant

    Collapse Overview 
    Collapse Overview
    Daniel Cooke, MD, is an Assistant Professor in Residence of Neuro Interventional Radiology in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. His expertise is in ischemic and hemorrhagic stroke, vascular malignancies of the central nervous system, arteriovenous malformations (AVM), arteriovenous fistula (AVF), and aneurysms of the brain and spine. Dr. Cooke earned his medical degree from Emory University, Atlanta in 2004, and completed his residency in Diagnostic Radiology at the University of Washington, Seattle. He completed a fellowship in Neuroradiology at the University of Washington, Seattle in 2010, followed by another fellowship in Neuro Interventional Radiology from the University of California, San Francisco in 2012.

    Dr. Cooke’s primary research is in the use of contemporary endovascular surgical methods to assess endothelial cells in the setting of neurovascular pathology. In his work with MR generated computational fluid dynamic data and microsurgical specimens he aims to characterize the local and regional molecular events underlying the evolution of aneurysms, AVMs, and AVFs.

    Dr. Cooke’s research interests include: endovascular biopsy, pre-natal brain AVM detection, endovascular brachytherapy, flat panel CT-fluoroscopically guided intervention, and chemoinfusion. Dr. Cooke is also involved in research on catheter-based interventions for hemorrhagic stroke as well as regenerative cell therapies for ischemic stroke.

    Neuro Interventional Radiology

    Ischemic and hemorrhagic stroke, vascular malignancies of the central nervous system, and arteriovenous malformations (AVM), arteriovenous fistula (AVF), and aneurysms of the brain and spine

    Professional Interests:
    Stroke, arteriovenous malformation, arteriovenous fistula, aneurysm, cerebral vascular disease, endothelium, intracerebral hemorrhage, spinal vascular anomalies, vascular cerebral, spinal, and head and neck malignancy, retinoblastoma, high and low flow vascular malformations

    Education and Training:
    • Medical School: Emory University, Atlanta, Georgia
    • Internship: University of Hawaii, Honolulu - Surgery
    • Residency: University of Washington, Seattle - Radiology
    • Fellowship: University of Washington, Seattle - Neuroradiology
    • Fellowship: University of California, San Francisco - Neuro Interventional
    • Medical licensure, California
    • American Board of Radiology with sub-specialty certification in Neuroradiology

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yu JF, Nicholson AD, Nelson J, Alexander MD, Tse SH, Hetts SW, Hemphill JC, Kim H, Cooke D. Predictors of intracranial hemorrhage volume and distribution in brain arteriovenous malformation. Interv Neuroradiol. 2018 Jan 01; 1591019917749819. PMID: 29343148.
      View in: PubMed
    2. Alexander MD, Rebhun JM, Hetts SW, Amans MR, Settecase F, Darflinger RJ, Dowd CF, Halbach VV, Higashida RT, Cooke D. Technical factors affecting outcomes following endovascular treatment of posterior circulation atherosclerotic lesions. Surg Neurol Int. 2017; 8:284. PMID: 29279801.
      View in: PubMed
    3. Cooke D, McCoy DB, Halbach VV, Hetts SW, Amans MR, Dowd CF, Higashida RT, Lawson D, Nelson J, Wang CY, Kim H, Werb Z, McCulloch C, Hashimoto T, Su H, Sun Z. Endovascular Biopsy: In Vivo Cerebral Aneurysm Endothelial Cell Sampling and Gene Expression Analysis. Transl Stroke Res. 2017 Sep 13. PMID: 28900857.
      View in: PubMed
    4. Chen X, Cooke D, Saloner D, Nelson J, Su H, Lawton MT, Hess C, Tihan T, Zhao Y, Kim H. Higher Flow Is Present in Unruptured Arteriovenous Malformations With Silent Intralesional Microhemorrhages. Stroke. 2017 Oct; 48(10):2881-2884. PMID: 28855391.
      View in: PubMed
    5. Mamlouk MD, Nicholson AD, Cooke D, Hess CP. Diffusion-weighted imaging for cutaneous vascular anomalies. Clin Imaging. 2017 Jul 28. PMID: 28768597.
      View in: PubMed
    6. Hirabayashi KE, Kalin-Hajdu E, Bever GJ, Vagefi MR, de Alba Campomanes AG, Cooke D, Dowd CF, Kersten RC. Normalization of Congenital Venous Stasis Retinopathy Following Sclerotherapy of a Macrocystic Lymphatic Malformation. Ophthal Plast Reconstr Surg. 2017 Jul 25. PMID: 28746255.
      View in: PubMed
    7. Derdeyn CP, Zipfel GJ, Albuquerque FC, Cooke D, Feldmann E, Sheehan JP, Torner JC. Management of Brain Arteriovenous Malformations: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2017 Aug; 48(8):e200-e224. PMID: 28642352.
      View in: PubMed
    8. Mamlouk MD, Nicholson AD, Cooke D, Hess CP. Tips and tricks to optimize MRI protocols for cutaneous vascular anomalies. Clin Imaging. 2017 Sep - Oct; 45:71-80. PMID: 28622551.
      View in: PubMed
    9. Alexander MD, Hippe DS, Cooke D, Hallam DK, Hetts SW, Kim H, Lawton MT, Sekhar LN, Kim LJ, Ghodke BV. Targeted Embolization of Aneurysms Associated With Brain Arteriovenous Malformations at High Risk for Surgical Resection: A Case-Control Study. Neurosurgery. 2017 Apr 13. PMID: 28419337.
      View in: PubMed
    10. Settecase F, McCoy DB, Darflinger R, Alexander MD, Cooke D, Dowd CF, Hetts SW, Higashida RT, Halbach VV, Amans MR. Improving mechanical thrombectomy time metrics in the angiography suite: Stroke cart, parallel workflows, and conscious sedation. Interv Neuroradiol. 2017 Jan 01; 1591019917742326. PMID: 29145742.
      View in: PubMed
    11. Lum MA, Martin AJ, Alexander MD, McCoy DB, Cooke D, Lillaney P, Moftakhar P, Amans MR, Settecase F, Nicholson A, Dowd CF, Halbach VV, Higashida RT, McDermott MW, Saloner D, Hetts SW. Intra-Arterial MR Perfusion Imaging of Meningiomas: Comparison to Digital Subtraction Angiography and Intravenous MR Perfusion Imaging. PLoS One. 2016; 11(11):e0163554. PMID: 27802268.
      View in: PubMed
    12. Alexander MD, Nicholson AD, Darflinger RJ, Settecase F, Cooke D, Dowd CF, Amans MR, Higashida RT, Hetts SW, Halbach VV. Effects on vessel measurement accuracy and subsequent occlusion after calcium channel blocker infusion during treatment of cerebral aneurysms with the Pipeline embolization device. Interv Neuroradiol. 2017 Feb; 23(1):47-51. PMID: 27798327.
      View in: PubMed
    13. Hetts SW, Moftakhar P, Maluste N, Fullerton HJ, Cooke D, Amans MR, Dowd CF, Higashida RT, Halbach VV. Pediatric intracranial dural arteriovenous fistulas: age-related differences in clinical features, angioarchitecture, and treatment outcomes. J Neurosurg Pediatr. 2016 Nov; 18(5):602-610. PMID: 27540826.
      View in: PubMed
    14. Alexander MD, Cooke D, Hallam DK, Kim H, Hetts SW, Ghodke BV. Less can be more: Targeted embolization of aneurysms associated with arteriovenous malformations unsuitable for surgical resection. Interv Neuroradiol. 2016 Aug; 22(4):445-51. PMID: 27066813; PMCID: PMC4984389 [Available on 08/01/17].
    15. Lillaney PV, Yang JK, Losey AD, Martin AJ, Cooke D, Thorne BR, Barry DC, Chu A, Stillson C, Do L, Arenson RL, Saeed M, Wilson MW, Hetts SW. Endovascular MR-guided Renal Embolization by Using a Magnetically Assisted Remote-controlled Catheter System. Radiology. 2016 Oct; 281(1):219-28. PMID: 27019290.
      View in: PubMed
    16. Settecase F, Nicholson AD, Amans MR, Higashida RT, Halbach VV, Cooke D, Dowd CF, Hetts SW. Onyx embolization of an intraosseous pseudoaneurysm of the middle meningeal artery in a patient with meningiomatosis, McCune-Albright syndrome, and gray platelet syndrome. J Neurosurg Pediatr. 2016 Mar; 17(3):324-9. PMID: 26588455.
      View in: PubMed
    17. Settecase F, Hetts SW, Nicholson AD, Amans MR, Cooke D, Dowd CF, Higashida RT, Halbach VV. Superselective Intra-Arterial Ethanol Sclerotherapy of Feeding Artery and Nidal Aneurysms in Ruptured Cerebral Arteriovenous Malformations. AJNR Am J Neuroradiol. 2016 Apr; 37(4):692-7. PMID: 26564434.
      View in: PubMed
    18. Narvid J, Amans MR, Cooke D, Hetts SW, Dillon WP, Higashida RT, Dowd CF, Halbach VV. Spontaneous retroclival hematoma: a case series. J Neurosurg. 2016 Mar; 124(3):716-9. PMID: 26252463.
      View in: PubMed
    19. Cooke D, Levitt MR, Kim LJ, Hallam DK, Sekhar LN, Ghodke BV. Laser-assisted flat-detector CT-guided intracranial access. Int J Comput Assist Radiol Surg. 2016 Mar; 11(3):467-72. PMID: 26239371.
      View in: PubMed
    20. Sun Z, Lawson DA, Sinclair E, Wang CY, Lai MD, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Werb Z, Su H, Cooke D. Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels?. Biotechnol Rep (Amst). 2015 Sep; 7:157-165. PMID: 26989654.
      View in: PubMed
    21. Hetts SW, Tsai T, Cooke D, Amans MR, Settecase F, Moftakhar P, Dowd CF, Higashida RT, Lawton MT, Halbach VV. Progressive versus Nonprogressive Intracranial Dural Arteriovenous Fistulas: Characteristics and Outcomes. AJNR Am J Neuroradiol. 2015 Oct; 36(10):1912-9. PMID: 26206813.
      View in: PubMed
    22. Mabray MC, Datta S, Lillaney PV, Moore T, Gehrisch S, Talbott JF, Levitt MR, Ghodke BV, Larson PS, Cooke D. Accuracy of flat panel detector CT with integrated navigational software with and without MR fusion for single-pass needle placement. J Neurointerv Surg. 2016 Jul; 8(7):731-5. PMID: 26047903.
      View in: PubMed
    23. Moftakhar P, Lillaney P, Losey AD, Cooke D, Martin AJ, Thorne BR, Arenson RL, Saeed M, Wilson MW, Hetts SW. New-Generation Laser-lithographed Dual-Axis Magnetically Assisted Remote-controlled Endovascular Catheter for Interventional MR Imaging: In Vitro Multiplanar Navigation at 1.5 T and 3 T versus X-ray Fluoroscopy. Radiology. 2015 Dec; 277(3):842-52. PMID: 26030659; PMCID: PMC4671459.
    24. Alexander MD, Rebhun JM, Hetts SW, Kim AS, Nelson J, Kim H, Amans MR, Settecase F, Dowd CF, Halbach VV, Higashida RT, Cooke D. Lesion location, stability, and pretreatment management: factors affecting outcomes of endovascular treatment for vertebrobasilar atherosclerosis. J Neurointerv Surg. 2016 May; 8(5):466-70. PMID: 25795438.
      View in: PubMed
    25. Cooke D, Bauer D, Sun Z, Stillson C, Nelson J, Barry D, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Su H, Saeed MM. Endovascular biopsy: Technical feasibility of novel endothelial cell harvesting devices assessed in a rabbit aneurysm model. Interv Neuroradiol. 2015 Feb; 21(1):120-8. PMID: 25934786; PMCID: PMC4757193.
    26. Alexander MD, Cooke D, Nelson J, Guo DE, Dowd CF, Higashida RT, Halbach VV, Lawton MT, Kim H, Hetts SW. Association between Venous Angioarchitectural Features of Sporadic Brain Arteriovenous Malformations and Intracranial Hemorrhage. AJNR Am J Neuroradiol. 2015 May; 36(5):949-52. PMID: 25634722; PMCID: PMC4433780.
    27. Moftakhar P, Cooke D, Fullerton HJ, Ko NU, Amans MR, Narvid JA, Dowd CF, Higashida RT, Halbach VV, Hetts SW. Extent of collateralization predicting symptomatic cerebral vasospasm among pediatric patients: correlations among angiography, transcranial Doppler ultrasonography, and clinical findings. J Neurosurg Pediatr. 2015 Mar; 15(3):282-90. PMID: 25555113.
      View in: PubMed
    28. Sun Z, Su H, Long B, Sinclair E, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Cooke D. Endothelial cell high-enrichment from endovascular biopsy sample by laser capture microdissection and fluorescence activated cell sorting. J Biotechnol. 2014 Dec 20; 192 Pt A:34-9. PMID: 25450638; PMCID: PMC4654108.
    29. Alexander MD, Cooke D, Meyers PM, Amans MR, Dowd CF, Halbach VV, Higashida RT, Hetts SW. Lesion stability characteristics outperform degree of stenosis in predicting outcomes following stenting for symptomatic intracranial atherosclerosis. J Neurointerv Surg. 2016 Jan; 8(1):19-23. PMID: 25416828.
      View in: PubMed
    30. Raygor KP, Rowland NC, Cooke D, Solomon DA, Huang MC. Aneurysm of the posterior meningeal artery embedded within a dorsal exophytic medullary hemangioblastoma: surgical management and review of literature. J Cerebrovasc Endovasc Neurosurg. 2014 Sep; 16(3):293-8. PMID: 25340034; PMCID: PMC4205258.
    31. Cooke D, Stout CE, Kim WT, Kansagra AP, Yu JP, Gu A, Jewell NP, Hetts SW, Higashida RT, Dowd CF, Halbach VV. Cerebral arterial fenestrations. Interv Neuroradiol. 2014 May-Jun; 20(3):261-74. PMID: 24976087; PMCID: PMC4178766.
    32. Chow ML, Cooke D, Fullerton HJ, Amans MR, Narvid J, Dowd CF, Higashida RT, Halbach VV, Hetts SW. Radiological and clinical features of vein of Galen malformations. J Neurointerv Surg. 2015 Jun; 7(6):443-8. PMID: 24789593.
      View in: PubMed
    33. Alexander MD, Meyers PM, English JD, Stradford TR, Sung S, Smith WS, Halbach VV, Higashida RT, Dowd CF, Cooke D, Hetts SW. Symptom differences and pretreatment asymptomatic interval affect outcomes of stenting for intracranial atherosclerotic disease. AJNR Am J Neuroradiol. 2014 Jun; 35(6):1157-62. PMID: 24676000.
      View in: PubMed
    34. Hetts SW, Cooke D, Nelson J, Gupta N, Fullerton H, Amans MR, Narvid JA, Moftakhar P, McSwain H, Dowd CF, Higashida RT, Halbach VV, Lawton MT, Kim H. Influence of patient age on angioarchitecture of brain arteriovenous malformations. AJNR Am J Neuroradiol. 2014 Jul; 35(7):1376-80. PMID: 24627452; PMCID: PMC4102659.
    35. Losey AD, Lillaney P, Martin AJ, Cooke D, Wilson MW, Thorne BR, Sincic RS, Arenson RL, Saeed M, Hetts SW. Magnetically assisted remote-controlled endovascular catheter for interventional MR imaging: in vitro navigation at 1.5 T versus X-ray fluoroscopy. Radiology. 2014 Jun; 271(3):862-9. PMID: 24533872; PMCID: PMC4065602.
    36. Amans MR, Cooke D, Vella M, Dowd CF, Halbach VV, Higashida RT, Hetts SW. Contrast staining on CT after DSA in ischemic stroke patients progresses to infarction and rarely hemorrhages. Interv Neuroradiol. 2014 Jan-Feb; 20(1):106-15. PMID: 24556308; PMCID: PMC3971133.
    37. Sincic RS, Caton CJ, Lillaney P, Goodfriend S, Ni J, Martin AJ, Losey AD, Shah N, Yee EJ, Evans L, Malba V, Bernhardt AF, Settecase F, Cooke D, Saeed M, Wilson MW, Hetts SW. System architecture for a magnetically guided endovascular microcatheter. Biomed Microdevices. 2014 Feb; 16(1):97-106. PMID: 24132857; PMCID: PMC3945604.
    38. Lillaney P, Caton C, Martin AJ, Losey AD, Evans L, Saeed M, Cooke D, Wilson MW, Hetts SW. Comparing deflection measurements of a magnetically steerable catheter using optical imaging and MRI. Med Phys. 2014 Feb; 41(2):022305. PMID: 24506643; PMCID: PMC3987686.
    39. Cooke D, Stout CE, Kim WT, Hetts SW, Higashida RT, Halbach VV, Dowd CF, Gould RG. Radiation dose reduction in intra-arterial chemotherapy infusion for intraocular retinoblastoma. J Neurointerv Surg. 2014 Dec; 6(10):785-9. PMID: 24385553.
      View in: PubMed
    40. Amans MR, Stout C, Fox C, Narvid J, Hetts SW, Cooke D, Higashida RT, Dowd CF, McSwain H, Halbach VV. Cerebral arteriopathy associated with Arg179His ACTA2 mutation. J Neurointerv Surg. 2014 Nov; 6(9):e46. PMID: 24353327.
      View in: PubMed
    41. Cooke D, Su H, Sun Z, Guo Y, Guo D, Saeed MM, Hetts SW, Higashida RT, Dowd CF, Young WL, Halbach VV. Endovascular biopsy: evaluating the feasibility of harvesting endothelial cells using detachable coils. Interv Neuroradiol. 2013 Dec; 19(4):399-408. PMID: 24355142; PMCID: PMC3902737.
    42. Hetts SW, English JD, Stiver SI, Singh V, Yee EJ, Cooke D, Halbach VV. Bilateral cervical spinal dural arteriovenous fistulas with intracranial venous drainage mimicking a foramen magnum dural arteriovenous fistula. Interv Neuroradiol. 2013 Dec; 19(4):483-8. PMID: 24355154; PMCID: PMC3902749.
    43. Amans MR, Stout C, Fox C, Narvid J, Hetts SW, Cooke D, Higashida RT, Dowd CF, McSwain H, Halbach VV. Cerebral arteriopathy associated with Arg179His ACTA2 mutation. BMJ Case Rep. 2013 Nov 29; 2013. PMID: 24293535; PMCID: PMC3847515.
    44. Sheth SA, Potts MB, Sneed PK, Young WL, Cooke D, Gupta N, Hetts SW. Angiographic features help predict outcome after stereotactic radiosurgery for the treatment of pediatric arteriovenous malformations. Childs Nerv Syst. 2014 Feb; 30(2):241-7. PMID: 23892391.
      View in: PubMed
    45. Thampi S, Hetts SW, Cooke D, Stewart PJ, Robbins E, Banerjee A, Dubois SG, Char D, Halbach V, Matthay K. Superselective intra-arterial melphalan therapy for newly diagnosed and refractory retinoblastoma: results from a single institution. Clin Ophthalmol. 2013; 7:981-9. PMID: 23818751; PMCID: PMC3693581.
    46. Losey AD, Lillaney P, Martin AJ, Halbach VV, Cooke D, Dowd CF, Higashida RT, Saloner DA, Wilson MW, Saeed M, Hetts SW. Safety of retained microcatheters: an evaluation of radiofrequency heating in endovascular microcatheters with nitinol, tungsten, and polyetheretherketone braiding at 1.5 T and 3 T. J Neurointerv Surg. 2014 May; 6(4):314-9. PMID: 23685793; PMCID: PMC3796159.
    47. Hetts SW, Saeed M, Martin A, Lillaney P, Losey A, Yee EJ, Sincic R, Do L, Evans L, Malba V, Bernhardt AF, Wilson MW, Patel A, Arenson RL, Caton C, Cooke D. Magnetically-Assisted Remote Controlled Microcatheter Tip Deflection under Magnetic Resonance Imaging. J Vis Exp. 2013 Apr 04; (74). PMID: 23609143; PMCID: PMC3643177.
    48. Kansagra AP, Cooke D, English JD, Sincic RM, Amans MR, Dowd CF, Halbach VV, Higashida RT, Hetts SW. Current trends in endovascular management of traumatic cerebrovascular injury. J Neurointerv Surg. 2014 Jan; 6(1):47-50. PMID: 23322749.
      View in: PubMed
    49. Moftakhar P, English JD, Cooke D, Kim WT, Stout C, Smith WS, Dowd CF, Higashida RT, Halbach VV, Hetts SW. Density of thrombus on admission CT predicts revascularization efficacy in large vessel occlusion acute ischemic stroke. Stroke. 2013 Jan; 44(1):243-5. PMID: 23111438.
      View in: PubMed
    50. Cooke D, Meisel KM, Kim WT, Stout CE, Halbach VV, Dowd CF, Higashida RT. Serial angiographic appearance of segmental arterial mediolysis manifesting as vertebral, internal mammary and intra-abdominal visceral artery aneurysms in a patient presenting with subarachnoid hemorrhage and review of the literature. J Neurointerv Surg. 2013 Sep 01; 5(5):478-82. PMID: 22693248.
      View in: PubMed
    51. Cooke D, Johnson G, Levitt MR, Lewis DH, Sekhar LN, Ghodke B. Synchronous chronic middle cerebral artery occlusion and ipsilateral dural arteriovenous fistula. Clin Nucl Med. 2011 Jul; 36(7):570-3. PMID: 21637062.
      View in: PubMed
    52. Levitt MR, Cooke D, Ghodke BV, Kim LJ, Hallam DK, Sekhar LN. "Stent view" flat-detector CT and stent-assisted treatment strategies for complex intracranial aneurysms. World Neurosurg. 2011 Feb; 75(2):275-8. PMID: 21492730.
      View in: PubMed
    53. Cooke D, Levitt M, Kim LJ, Hallam DK, Ghodke B. Intraorbital access using fluoroscopic flat panel detector CT navigation and three-dimensional MRI overlay. J Neurointerv Surg. 2010 Sep; 2(3):249-51. PMID: 21990636.
      View in: PubMed
    54. Levitt MR, Ghodke BV, Cooke D, Hallam DK, Kim LJ, Sekhar LN. Endovascular procedures with CTA and MRA roadmapping. J Neuroimaging. 2011 Jul; 21(3):259-62. PMID: 20649854.
      View in: PubMed
    55. Cooke D, Levitt M, Kim LJ, Hallam DK, Ghodke B. Transcranial access using fluoroscopic flat panel detector CT navigation. AJNR Am J Neuroradiol. 2011 Apr; 32(4):E69-70. PMID: 20299429.
      View in: PubMed
    56. Wilson MA, Cooke D, Ghodke B, Mirza SK. Retrospective analysis of preoperative embolization of spinal tumors. AJNR Am J Neuroradiol. 2010 Apr; 31(4):656-60. PMID: 19942697.
      View in: PubMed
    57. Konowal A, Morrison JC, Brown SV, Cooke D, Maguire LJ, Verdier DV, Fraunfelder FT, Dennis RF, Epstein RJ. Irreversible corneal decompensation in patients treated with topical dorzolamide. Am J Ophthalmol. 1999 Apr; 127(4):403-6. PMID: 10218692.
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