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Chelsea Bahney, PhD

TitleAssistant Professor
SchoolUCSF School of Medicine
DepartmentOrthopaedic Surgery
Address1001 Potrero Ave, SFGH 9
San Francisco CA 94110
Phone415-206-5362
EmailChelsea.Bahney@ucsf.edu
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    Collapse Biography 
    Collapse Education and Training
    University of Colorado, Boulder, COBS06/2001Chemical Engineering
    Valleylab (now Medtronic), Boulder, CO08/2005R&D Engineer
    Oregon Health & Science University, Portland, ORPhD08/2010Stem Cell & Developmental Biology
    University of California, San Francisco, San Francisco, CAPost-Doctoral Fellowship04/2014Orthopaedic Surgery

    Collapse Overview 
    Collapse Overview
    The overall goal of my research is to develop novel therapies for the treatment of musculoskeletal diseases and injuries. Specifically, I believe we can drive improved tissue regeneration by recapitulating the normal sequences of development and repair. To accomplish this ā€œDevelopmental Engineeringā€ approach our laboratory utilizes a cross-disciplinary tools combining biologically modified synthetic polymers, stem cell biology, and murine models of orthopaedic injuries. The long-term goal of our research is to solve problems that will have a direct and significant impact on human health.

    Current Projects:

    (1) Tissue engineering strategies to promote endochondral bone regeneration
    (2) Transdifferentiation of cartilage to bone during fracture repair and osteoarthritis
    (3) The role of the nerve in fracture repair
    (4) Polytraumatic Injuries: How brain trauma influences fracture healing
    (5) Impedance sensors to monitor fracture healing


    Collapse Research 
    Collapse Research Activities and Funding
    Bimodal therapeutic application of LIF for regulating chondrogenic fate
    UCSF Center for Center for Musculoskeletal Biology and Medicine Jul 1, 2017 - Jul 1, 2018
    Role: PI
    Innervation during fracture repair: exploring functional mechanisms and innovative therapeutic repair strategies.
    Foundation of Orthopaedic Trauma Oct 1, 2015 - Oct 1, 2017
    Role: PI
    Promoting vascularized bone regeneration with endochondral cartilage grafts
    AO Foundation Start Up Grant Jun 1, 2015 - Jan 1, 2018
    Role: PI
    A Murine Model of Polytrauma: Understanding the molecular basis of accelerated bone repair with concomitant traumatic brain injury.
    NIH R21May 1, 2015 - Dec 31, 2017
    Role: Co-Investigator
    OsteoNova: Tissue Engineering Approach to Translating Endochondral Bone Regeneration
    UCSF Catalyst Mar 1, 2015 - Jun 30, 2017
    Role: PI
    Development of a Novel Impedance Sensor to Monitor Fracture Healing
    NSF Center for Disruptive Musculoskeletal Innovation Aug 1, 2014 - Aug 1, 2017
    Role: Co-PI
    Tissue engineering application of endochondral ossification for bone regeneration
    NIH/NIAMS F32AR062469Mar 1, 2012 - Feb 28, 2015
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Miclau KR, Brazina SA, Bahney CS, Hankenson KD, Hunt TK, Marcucio RS, Miclau T. Stimulating Fracture Healing in Ischemic Environments: Does Oxygen Direct Stem Cell Fate during Fracture Healing? Front Cell Dev Biol. 2017; 5:45. PMID: 28523266.
      View in: PubMed
    2. Lin MC, Yang F, Herfat ST, Bahney CS, Marmor M, Maharbiz MM. New opportunities for fracture healing detection: Impedance spectroscopy measurements correlate to tissue composition in fractures. J Orthop Res. 2017 Apr 06. PMID: 28383765.
      View in: PubMed
    3. Hu DP, Ferro F, Yang F, Taylor AJ, Chang W, Miclau T, Marcucio RS, Bahney CS. Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes. Development. 2017 Jan 15; 144(2):221-234. PMID: 28096214.
      View in: PubMed
    4. Bahney CS, Bruder SP, Cain JD, Keyak JH, Killian ML, Shapiro IM, Jones LC. Accelerating the pace of discovery in orthopaedic research: A vision toward team science. J Orthop Res. 2016 Oct; 34(10):1673-1679. PMID: 27219218.
      View in: PubMed
    5. Bahney CS, Jacobs L, Tamai R, Hu D, Luan TF, Wang M, Reddy S, Park M, Limburg S, Kim HT, Marcucio R, Kuo AC. Promoting Endochondral Bone Repair Using Human Osteoarthritic Articular Chondrocytes. Tissue Eng Part A. 2016 Mar; 22(5-6):427-35. PMID: 26830207; PMCID: PMC4800268 [Available on 03/01/17].
    6. Marcucio RS, Nauth A, Giannoudis PV, Bahney C, Piuzzi NS, Muschler G, Miclau T. Stem Cell Therapies in Orthopaedic Trauma. J Orthop Trauma. 2015 Dec; 29 Suppl 12:S24-7. PMID: 26584262; PMCID: PMC4845034 [Available on 12/01/16].
    7. Giannoudis PV, Hak D, Sanders D, Donohoe E, Tosounidis T, Bahney C. Inflammation, Bone Healing, and Anti-Inflammatory Drugs: An Update. J Orthop Trauma. 2015 Dec; 29 Suppl 12:S6-9. PMID: 26584270.
      View in: PubMed
    8. Almubarak S, Nethercott H, Freeberg M, Beaudon C, Jha A, Jackson W, Marcucio R, Miclau T, Healy K, Bahney C. Tissue engineering strategies for promoting vascularized bone regeneration. Bone. 2016 Feb; 83:197-209. PMID: 26608518; PMCID: PMC4911893 [Available on 02/01/17].
    9. Song S, Kim EJ, Bahney CS, Miclau T, Marcucio R, Roy S. The synergistic effect of micro-topography and biochemical culture environment to promote angiogenesis and osteogenic differentiation of human mesenchymal stem cells. Acta Biomater. 2015 May; 18:100-11. PMID: 25735800.
      View in: PubMed
    10. Bahney CS, Hu DP, Miclau T, Marcucio RS. The multifaceted role of the vasculature in endochondral fracture repair. Front Endocrinol (Lausanne). 2015; 6:4. PMID: 25699016; PMCID: PMC4318416.
    11. Bahney, CS; Hu, DP; Miclau, T; Marcucio, RS. Review Article. The multifaceted role of the vasculature in endochondral fracture repair. 2015.
    12. Lin MC, Herfat ST, Bahney CS, Marmor M, Maharbiz MM. Impedance spectroscopy to monitor fracture healing. Conf Proc IEEE Eng Med Biol Soc. 2015; 2015:5138-41. PMID: 26737448.
      View in: PubMed
    13. Bahney CS, Hu DP, Taylor AJ, Ferro F, Britz HM, Hallgrimsson B, Johnstone B, Miclau T, Marcucio RS. Stem cell-derived endochondral cartilage stimulates bone healing by tissue transformation. J Bone Miner Res. 2014; 29(5):1269-82. PMID: 24259230; PMCID: PMC4802866.
    14. Yu YY, Bahney C, Hu D, Marcucio RS, Miclau T. Creating rigidly stabilized fractures for assessing intramembranous ossification, distraction osteogenesis, or healing of critical sized defects. J Vis Exp. 2012 Apr 11; (62). PMID: 22525683; PMCID: PMC3466651.
    15. Bahney CS, Miclau T. Therapeutic potential of stem cells in orthopedics. Indian J Orthop. 2012 Jan; 46(1):4-9. PMID: 22345800; PMCID: PMC3270604.
    16. Bahney CS, Lujan TJ, Hsu CW, Bottlang M, West JL, Johnstone B. Visible light photoinitiation of mesenchymal stem cell-laden bioresponsive hydrogels. Eur Cell Mater. 2011 Jul 15; 22:43-55; discussion 55. PMID: 21761391.
      View in: PubMed
    17. Bahney CS, Hsu CW, Yoo JU, West JL, Johnstone B. A bioresponsive hydrogel tuned to chondrogenesis of human mesenchymal stem cells. FASEB J. 2011 May; 25(5):1486-96. PMID: 21282205.
      View in: PubMed
    18. Lujan TJ, Wirtz KM, Bahney CS, Madey SM, Johnstone B, Bottlang M. A novel bioreactor for the dynamic stimulation and mechanical evaluation of multiple tissue-engineered constructs. Tissue Eng Part C Methods. 2011 Mar; 17(3):367-74. PMID: 20950252; PMCID: PMC3045075.
    19. Buxton AN, Bahney CS, Yoo JU, Johnstone B. Temporal exposure to chondrogenic factors modulates human mesenchymal stem cell chondrogenesis in hydrogels. Tissue Eng Part A. 2011 Feb; 17(3-4):371-80. PMID: 20799905; PMCID: PMC3028992.
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