Galateia Kazakia, PhD
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Title(s) | Associate Professor, Radiology |
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School | School of Medicine |
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Address | 185 Berry Street Bldg B San Francisco CA 94158
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Phone | 415-353-4534 |
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vCard | Download vCard |
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Biography Cornell University, Ithaca, NY | BS | 1995 | Mechanical Engineering | University of California, Berkeley | PhD | 2005 | Mechanical Engineering | University of California, San Francisco | Postdoctoral Studies | | Graduate Division | University of California, San Francisco | | 2019 | Diversity, Equity, and Inclusion Champion Training |
International Society of Magnetic Resonance in Medicine | 2020 | | Summa Cum Laude Award | American Society of Bone and Mineral Research | 2019 | | Plenary Poster Award | UCSF School of Medicine | 2018 | | Faculty Travel Award | Center for Disruptive Musculoskeletal Innovations | 2015 | | Featured Investigator | American Society for Bone and Mineral Research | 2014 | | Plenary Poster Award | National Institutes of Health | 2009 | | Mentored Career Development Award | Musculoskeletal Quantitative Imaging Research Group | 2006 | | Excellence in Research Award | International Sun Valley Workshop of Skeletal Biology | 2006 | | Young Investigator Award | National Science Foundation | 1999 | | Graduate Research Fellowship |
Overview Galateia J. Kazakia, PhD, is an Associate Professor in Residence and Director of Bone Quality Research Laboratory in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. Dr. Kazakia serves as the Faculty Director of the Quantitative Micro-Imaging Core and Co-Director of the UCSF Core Center for Musculoskeletal Biology and Medicine (CCMBM P30) Imaging Core. Dr. Kazakia received her BS in Mechanical Engineering from Cornell University in Ithaca, New York in 1995. She completed her PhD in Mechanical Engineering (with an emphasis on Bone Biomechanics) from the University of California, Berkeley in 2004. Dr. Kazakia was awarded an NIH F32 postdoctoral fellowship to develop bone imaging techniques, performing this work in the Musculoskeletal Quantitative Imaging Research group at UCSF. Dr. Kazakia joined the UCSF Department of Radiology and Biomedical Imaging as an Assistant Professor in Residence in 2009.
Dr. Kazakia’s research is focused on the assessment of bone quality using both in vivo and ex vivo imaging tools, spanning the hierarchical levels of bone structure and composition. Through her research she aims to characterize changes occurring in the skeleton in response to aging and disease, to discover biological mechanisms of these changes, and to understand the impact skeletal changes have on bone strength and fracture risk.
Dr. Kazakia is an active member of the American Society for Bone and Mineral Research, the American Association for the Advancement of Science, and the Orthopaedic Research Society. Dr. Kazakia serves as a reviewer for >10 scientific journals, and she has published numerous peer-reviewed articles and conference abstracts.
Expertise: Musculoskeletal Radiology
Specialty: Musculoskeletal imaging, musculoskeletal diseases, CT, MRI, HR-pQCT, microCT, FTIR
Professional Interests: Mineralization, bone quality, bone architecture, bone micro-damage, biomechanics, mechanical properties, fourier transform infrared (FTIR) spectroscopy, high-resolution computed tomography (CT), fluorescence imaging
Education and Training: • Bachelor of Science: Cornell University, Ithaca, New York - Mechanical Engineering • Masters of Science: University of California, Berkeley - Mechanical Engineering • Doctor of Philosophy: University of California, Berkeley - Mechanical Engineering
Research ORNG Applications Bibliographic
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Microstructural abnormalities are evident by histology but not HR-pQCT at the periosteal cortex of the human tibia under CVD and T2D conditions. Medicine in Novel Technology and Devices. 2021 Feb 1; 100062.
Barbara Garita, Jenna Maligro, Saghi Sadoughi, Po Hung Wu, Ellen Liebenberg, Andrew Horvai, Thomas M. Link, Galateia J. Kazakia. .
View in: Publisher Site Mentions:
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Soft tissue variations influence HR-pQCT density measurements in a spatially dependent manner. Bone. 2020 09; 138:115505.
Wu PH, Gupta T, Chang H, Petrenko D, Schafer A, Kazakia G. PMID: 32599223.
View in: PubMed Mentions: Fields:
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Update on Imaging-Based Measurement of Bone Mineral Density and Quality. Curr Rheumatol Rep. 2020 04 09; 22(5):13.
Link TM, Kazakia G. PMID: 32270332.
View in: PubMed Mentions: 1 Fields:
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Factors associated with bone microstructural alterations assessed by HR-pQCT in long-term HIV-infected individuals. Bone. 2020 04; 133:115210.
Foreman SC, Wu PH, Kuang R, John MD, Tien PC, Link TM, Krug R, Kazakia GJ. PMID: 31874226.
View in: PubMed Mentions: Fields:
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Cortical bone vessel identification and quantification on contrast-enhanced MR images. Quant Imaging Med Surg. 2019 Jun; 9(6):928-941.
Wu PH, Gibbons M, Foreman SC, Carballido-Gamio J, Han M, Krug R, Liu J, Link TM, Kazakia GJ. PMID: 31367547.
View in: PubMed Mentions:
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Detection of Lumbar Spine Osseous Metastases Using Dual-Energy CT: Phantom Results and Preliminary Clinical Validation. AJR Am J Roentgenol. 2019 02; 212(2):402-410.
Huang HC, Srinivasan R, Sun Y, Kazakia GJ, Lin PC, Yeh BM. PMID: 30667316.
View in: PubMed Mentions: 1 Fields: Translation: Humans
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Bone remodeling following MR-guided focused ultrasound: Evaluation with HR-pQCT and FTIR. Bone. 2019 03; 120:347-353.
Bucknor MD, Goel H, Pasco C, Horvai AE, Kazakia GJ. PMID: 30453088.
View in: PubMed Mentions: Fields: Translation: Animals
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Cartilage Endplate Thickness Variation Measured by Ultrashort Echo-Time MRI Is Associated With Adjacent Disc Degeneration. Spine (Phila Pa 1976). 2018 05 15; 43(10):E592-E600.
Berg-Johansen B, Han M, Fields AJ, Liebenberg EC, Lim BJ, Larson PE, Gunduz-Demir C, Kazakia GJ, Krug R, Lotz JC. PMID: 28984733.
View in: PubMed Mentions: 9 Fields: Translation: Humans
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High-Impact Mechanical Loading Increases Bone Material Strength in Postmenopausal Women-A 3-Month Intervention Study. J Bone Miner Res. 2018 07; 33(7):1242-1251.
Sundh D, Nilsson M, Zoulakis M, Pasco C, Yilmaz M, Kazakia GJ, Hellgren M, Lorentzon M. PMID: 29578618.
View in: PubMed Mentions: 4 Fields: Translation: HumansCTClinical Trials
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Effects of Gastric Bypass Surgery on Bone Mass and Microarchitecture Occur Early and Particularly Impact Postmenopausal Women. J Bone Miner Res. 2018 06; 33(6):975-986.
Schafer AL, Kazakia GJ, Vittinghoff E, Stewart L, Rogers SJ, Kim TY, Carter JT, Posselt AM, Pasco C, Shoback DM, Black DM. PMID: 29281126.
View in: PubMed Mentions: 8 Fields: Translation: Humans
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Trabecular bone microstructure is impaired in the proximal femur of human immunodeficiency virus-infected men with normal bone mineral density. Quant Imaging Med Surg. 2018 Feb; 8(1):5-13.
Kazakia GJ, Carballido-Gamio J, Lai A, Nardo L, Facchetti L, Pasco C, Zhang CA, Han M, Parrott AH, Tien P, Krug R. PMID: 29541618.
View in: PubMed Mentions:
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A modular approach to creating large engineered cartilage surfaces. J Biomech. 2018 01 23; 67:177-183.
Ford AC, Chui WF, Zeng AY, Nandy A, Liebenberg E, Carraro C, Kazakia G, Alliston T, O'Connell GD. PMID: 29273221.
View in: PubMed Mentions: 2 Fields: Translation: Animals
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Role of Osteoblast Gi Signaling in Age-Related Bone Loss in Female Mice. Endocrinology. 2017 06 01; 158(6):1715-1726.
Millard SM, Wang L, Wattanachanya L, O'Carroll D, Fields AJ, Pang J, Kazakia G, Lotz JC, Nissenson RA. PMID: 28407060.
View in: PubMed Mentions: 3 Fields: Translation: AnimalsCells
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Statistical Parametric Mapping of HR-pQCT Images: A Tool for Population-Based Local Comparisons of Micro-Scale Bone Features. Ann Biomed Eng. 2017 04; 45(4):949-962.
Carballido-Gamio J, Bonaretti S, Kazakia GJ, Khosla S, Majumdar S, Lang TF, Burghardt AJ. PMID: 27830488.
View in: PubMed Mentions: 3 Fields: Translation: HumansCTClinical Trials
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Cortical bone laminar analysis reveals increased midcortical and periosteal porosity in type 2 diabetic postmenopausal women with history of fragility fractures compared to fracture-free diabetics. Osteoporos Int. 2016 09; 27(9):2791-2802.
Heilmeier U, Cheng K, Pasco C, Parrish R, Nirody J, Patsch JM, Zhang CA, Joseph GB, Burghardt AJ, Schwartz AV, Link TM, Kazakia G. PMID: 27154435.
View in: PubMed Mentions: 10 Fields: Translation: Humans
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FES-rowing attenuates bone loss following spinal cord injury as assessed by HR-pQCT. Spinal Cord Ser Cases. 2016; 2:15041.
Gibbons RS, Beaupre GS, Kazakia GJ. PMID: 28053743.
View in: PubMed Mentions: 3 Fields:
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Kartogenin treatment prevented joint degeneration in a rodent model of osteoarthritis: A pilot study. J Orthop Res. 2016 10; 34(10):1780-1789.
Mohan G, Magnitsky S, Melkus G, Subburaj K, Kazakia G, Burghardt AJ, Dang A, Lane NE, Majumdar S. PMID: 26895619.
View in: PubMed Mentions: 5 Fields: Translation: Animals
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Distinct Tissue Mineral Density in Plate- and Rod-like Trabeculae of Human Trabecular Bone. J Bone Miner Res. 2015 Sep; 30(9):1641-50.
Wang J, Kazakia GJ, Zhou B, Shi XT, Guo XE. PMID: 25736715.
View in: PubMed Mentions: 6 Fields: Translation: Humans
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Spatial distribution of intracortical porosity varies across age and sex. Bone. 2015 Jun; 75:88-95.
Nirody JA, Cheng KP, Parrish RM, Burghardt AJ, Majumdar S, Link TM, Kazakia GJ. PMID: 25701139.
View in: PubMed Mentions: 9 Fields: Translation: Humans
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Effect of intraspecimen spatial variation in tissue mineral density on the apparent stiffness of trabecular bone. J Biomech Eng. 2015 Jan; 137(1).
PMID: 25412197.
View in: PubMed Mentions: 1 Fields: Translation: Humans
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Validation of bone marrow fat quantification in the presence of trabecular bone using MRI. J Magn Reson Imaging. 2015 Aug; 42(2):539-44.
Gee CS, Nguyen JT, Marquez CJ, Heunis J, Lai A, Wyatt C, Han M, Kazakia G, Burghardt AJ, Karampinos DC, Carballido-Gamio J, Krug R. PMID: 25425074.
View in: PubMed Mentions: 20 Fields: Translation: Humans
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Population-based local multi-parametric comparisons of HR-pQCT studies. Journal of Orthopaedic Translation. 2014 Oct 1; 2(4):234-235.
Julio Carballido-Gamio, Serena Bonaretti, Galateia J. Kazakia, Sundeep Khosla, Thomas F. Lang, Andrew J. Burghardt. .
View in: Publisher Site Mentions:
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How tough is brittle bone? Investigating osteogenesis imperfecta in mouse bone. J Bone Miner Res. 2014 Jun; 29(6):1392-1401.
PMID: 24420672.
View in: PubMed Mentions: 29 Fields: Translation: AnimalsCells
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The influence of disuse on bone microstructure and mechanics assessed by HR-pQCT. Bone. 2014 Jun; 63:132-40.
PMID: 24603002.
View in: PubMed Mentions: 16 Fields: Translation: HumansCTClinical Trials
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Alterations of mass density and 3D osteocyte lacunar properties in bisphosphonate-related osteonecrotic human jaw bone, a synchrotron µCT study. PLoS One. 2014; 9(2):e88481.
PMID: 24586331.
View in: PubMed Mentions: 9 Fields: Translation: HumansCells
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Structural analysis of cortical porosity applied to HR-pQCT data. Med Phys. 2014 Jan; 41(1):013701.
PMID: 24387533.
View in: PubMed Mentions: 10 Fields: Translation: Humans
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Multicenter precision of cortical and trabecular bone quality measures assessed by high-resolution peripheral quantitative computed tomography. J Bone Miner Res. 2013 Mar; 28(3):524-36.
PMID: 23074145.
View in: PubMed Mentions: 29 Fields: Translation: Humans
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Age- and gender-related differences in cortical geometry and microstructure: Improved sensitivity by regional analysis. Bone. 2013 Feb; 52(2):623-31.
PMID: 23142360.
View in: PubMed Mentions: 19 Fields: Translation: Humans
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The role of oxygen during fracture healing. Bone. 2013 Jan; 52(1):220-9.
PMID: 23063782.
View in: PubMed Mentions: 26 Fields: Translation: AnimalsCells
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Bone and cartilage demonstrate changes localized to bone marrow edema-like lesions within osteoarthritic knees. Osteoarthritis Cartilage. 2013 Jan; 21(1):94-101.
PMID: 23025926.
View in: PubMed Mentions: 14 Fields: Translation: Humans
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The effect of voxel size on high-resolution peripheral computed tomography measurements of trabecular and cortical bone microstructure. Med Phys. 2012 Apr; 39(4):1893-903.
PMID: 22482611.
View in: PubMed Mentions: 32 Fields: Translation: Humans
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Noninvasive imaging of bone microarchitecture. Ann N Y Acad Sci. 2011 Dec; 1240:77-87.
PMID: 22172043.
View in: PubMed Mentions: 19 Fields: Translation: Humans
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Age-related differences in cortico-trabecular connectivity and load transfer in the distal radius measured in vivo by HR-pQCT. Bone. 2011 May 1; 48:s174.
A.J. Burghardt, G.J. Kazakia?, T.M. Link, S. Majumdar. .
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Longitudinal in vivo HR-pQCT assessment of the influence of non-weight bearing on bone quality. Bone. 2011 May 1; 48:s184.
W. Tjong, M. Sode, A. Burghardt, S. Majumdar, B. Feeley, B. Ma, G. Kazakia. .
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Mineral composition is altered by osteoblast expression of an engineered G(s)-coupled receptor. Calcif Tissue Int. 2011 Jul; 89(1):10-20.
Kazakia GJ, Speer D, Shanbhag S, Majumdar S, Conklin BR, Nissenson RA, Hsiao EC. PMID: 21526395.
View in: PubMed Mentions: 5 Fields: Translation: AnimalsCells
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Variations in morphological and biomechanical indices at the distal radius in subjects with identical BMD. J Biomech. 2011 Jan 11; 44(2):257-66.
Kazakia GJ, Burghardt AJ, Link TM, Majumdar S. PMID: 21071031.
View in: PubMed Mentions: 18 Fields: Translation: Humans
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Longitudinal evaluation of the effects of alendronate on MRI bone microarchitecture in postmenopausal osteopenic women. Bone. 2011 Mar 01; 48(3):611-21.
Folkesson J, Goldenstein J, Carballido-Gamio J, Kazakia G, Burghardt AJ, Rodriguez A, Krug R, de Papp AE, Link TM, Majumdar S. PMID: 21059422.
View in: PubMed Mentions: 14 Fields: Translation: Humans
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A longitudinal HR-pQCT study of alendronate treatment in postmenopausal women with low bone density: Relations among density, cortical and trabecular microarchitecture, biomechanics, and bone turnover. J Bone Miner Res. 2010 Dec; 25(12):2558-71.
Burghardt AJ, Kazakia GJ, Sode M, de Papp AE, Link TM, Majumdar S. PMID: 20564242.
View in: PubMed Mentions: 61 Fields: Translation: Humans
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Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia. J Bone Miner Res. 2010 May; 25(5):983-93.
Burghardt AJ, Kazakia GJ, Ramachandran S, Link TM, Majumdar S. PMID: 19888900.
View in: PubMed Mentions: 121 Fields: Translation: Humans
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Regional variations of gender-specific and age-related differences in trabecular bone structure of the distal radius and tibia. Bone. 2010 Jun; 46(6):1652-60.
Sode M, Burghardt AJ, Kazakia GJ, Link TM, Majumdar S. PMID: 20188877.
View in: PubMed Mentions: 24 Fields: Translation: Humans
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In vivo evaluation of the presence of bone marrow in cortical porosity in postmenopausal osteopenic women. Ann Biomed Eng. 2010 Feb; 38(2):235-46.
Goldenstein J, Kazakia G, Majumdar S. PMID: 19953321.
View in: PubMed Mentions: 12 Fields: Translation: Humans
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Three-dimensional surface texture visualization of bone tissue through epifluorescence-based serial block face imaging. J Microsc. 2009 Oct; 236(1):52-9.
Slyfield CR, Niemeyer KE, Tkachenko EV, Tomlinson RE, Steyer GG, Patthanacharoenphon CG, Kazakia GJ, Wilson DL, Hernandez CJ. PMID: 19772536.
View in: PubMed Mentions: 15 Fields: Translation: Animals
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392 BONE MARROW EDEMA-LIKE LESIONS IN OSTEOARTHRITIC SUBJECTS EXHIBIT ALTERED TRABECULAR STRUCTURE AND COMPOSITION. Osteoarthritis and Cartilage. 2009 Sep 1; 17:s206-s207.
G.J. Kazakia, D. Kuo, J. Schooler, S. Shanbhag, S. Majumdar, M. Ries, X. Li. .
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Assessment of trabecular bone structure using MDCT: comparison of 64- and 320-slice CT using HR-pQCT as the reference standard. Eur Radiol. 2010 Feb; 20(2):458-68.
Issever AS, Link TM, Kentenich M, Rogalla P, Burghardt AJ, Kazakia GJ, Majumdar S, Diederichs G. PMID: 19711081.
View in: PubMed Mentions: 20 Fields: Translation: Humans
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Accuracy of volumetric bone mineral density measurement in high-resolution peripheral quantitative computed tomography. Bone. 2009 Sep; 45(3):473-9.
Sekhon K, Kazakia GJ, Burghardt AJ, Hermannsson B, Majumdar S. PMID: 19501201.
View in: PubMed Mentions: 17 Fields: Translation: Humans
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Automated simulation of areal bone mineral density assessment in the distal radius from high-resolution peripheral quantitative computed tomography. Osteoporos Int. 2009 Dec; 20(12):2017-24.
Burghardt AJ, Kazakia GJ, Link TM, Majumdar S. PMID: 19330422.
View in: PubMed Mentions: 15 Fields: Translation: Humans
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Quantitative assessment of bone tissue mineralization with polychromatic micro-computed tomography. Calcif Tissue Int. 2008 Aug; 83(2):129-38.
Burghardt AJ, Kazakia GJ, Laib A, Majumdar S. PMID: 18685797.
View in: PubMed Mentions: 30 Fields: Translation: Animals
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Assessment of bone tissue mineralization by conventional x-ray microcomputed tomography: comparison with synchrotron radiation microcomputed tomography and ash measurements. Med Phys. 2008 Jul; 35(7):3170-9.
Kazakia GJ, Burghardt AJ, Cheung S, Majumdar S. PMID: 18697542.
View in: PubMed Mentions: 30 Fields: Translation: Humans
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In vivo determination of bone structure in postmenopausal women: a comparison of HR-pQCT and high-field MR imaging. J Bone Miner Res. 2008 Apr; 23(4):463-74.
Kazakia GJ, Hyun B, Burghardt AJ, Krug R, Newitt DC, de Papp AE, Link TM, Majumdar S. PMID: 18052756.
View in: PubMed Mentions: 60 Fields: Translation: Humans
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Assessment of trabecular bone structure comparing magnetic resonance imaging at 3 Tesla with high-resolution peripheral quantitative computed tomography ex vivo and in vivo. Osteoporos Int. 2008 May; 19(5):653-61.
Krug R, Carballido-Gamio J, Burghardt AJ, Kazakia G, Hyun BH, Jobke B, Banerjee S, Huber M, Link TM, Majumdar S. PMID: 17992467.
View in: PubMed Mentions: 24 Fields: Translation: Humans
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Validity of serial milling-based imaging system for microdamage quantification. Bone. 2008 Jan; 42(1):212-5.
Bigley RF, Singh M, Hernandez CJ, Kazakia GJ, Martin RB, Keaveny TM. PMID: 17951125.
View in: PubMed Mentions: 6 Fields: Translation: Humans
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A local adaptive threshold strategy for high resolution peripheral quantitative computed tomography of trabecular bone. Ann Biomed Eng. 2007 Oct; 35(10):1678-86.
Burghardt AJ, Kazakia GJ, Majumdar S. PMID: 17602299.
View in: PubMed Mentions: 35 Fields: Translation: Humans
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Automated high-resolution three-dimensional fluorescence imaging of large biological specimens. J Microsc. 2007 Feb; 225(Pt 2):109-17.
Kazakia GJ, Lee JJ, Singh M, Bigley RF, Martin RB, Keaveny TM. PMID: 17359245.
View in: PubMed Mentions: 6 Fields: Translation: Animals
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Effects of in vitro bone formation on the mechanical properties of a trabeculated hydroxyapatite bone substitute. J Biomed Mater Res A. 2006 Jun 15; 77(4):688-99.
Kazakia GJ, Nauman EA, Ebenstein DM, Halloran BP, Keaveny TM. PMID: 16514602.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimalsCells
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New imaging technologies in the diagnosis of osteoporosis. Rev Endocr Metab Disord. 2006 Jun; 7(1-2):67-74.
Kazakia GJ, Majumdar S. PMID: 17043763.
View in: PubMed Mentions: 25 Fields: Translation: Humans
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Year | Publications |
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2006 | 2 | 2007 | 4 | 2008 | 3 | 2009 | 6 | 2010 | 5 | 2011 | 4 | 2012 | 4 | 2013 | 1 | 2014 | 6 | 2015 | 3 | 2016 | 4 | 2017 | 2 | 2018 | 6 | 2019 | 2 | 2020 | 2 | 2021 | 1 |
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Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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