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Galateia Kazakia, PhD

Title(s)Associate Professor, Radiology
SchoolSchool of Medicine
Phone415-353-4534
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesGraduate Division
    University of California, San Francisco, CA2019Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    National Institutes of Health2009Mentored Career Development Award
    Musculoskeletal Quantitative Imaging Research Group2006Excellence in Research Award
    International Sun Valley Workshop of Skeletal Biology2006Young Investigator Award
    National Science Foundation1999Graduate Research Fellowship

    Collapse Overview 
    Collapse Overview
    Galateia J. Kazakia, PhD, is an Associate Professor in Residence and Director of Bone Quality Research Laboratory in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. Dr. Kazakia serves as the Faculty Director of the Quantitative Micro-Imaging Core and Co-Director of the UCSF Core Center for Musculoskeletal Biology and Medicine (CCMBM P30) Imaging Core. Dr. Kazakia received her BS in Mechanical Engineering from Cornell University in Ithaca, New York in 1995. She completed her PhD in Mechanical Engineering (with an emphasis on Bone Biomechanics) from the University of California, Berkeley in 2004. Dr. Kazakia was awarded an NIH F32 postdoctoral fellowship to develop bone imaging techniques, performing this work in the Musculoskeletal Quantitative Imaging Research group at UCSF. Dr. Kazakia joined the UCSF Department of Radiology and Biomedical Imaging as an Assistant Professor in Residence in 2009.

    Dr. Kazakia’s research is focused on the assessment of bone quality using both in vivo and ex vivo imaging tools, spanning the hierarchical levels of bone structure and composition. Through her research she aims to characterize changes occurring in the skeleton in response to aging and disease, to discover biological mechanisms of these changes, and to understand the impact skeletal changes have on bone strength and fracture risk.

    Dr. Kazakia is an active member of the American Society for Bone and Mineral Research, the American Association for the Advancement of Science, and the Orthopaedic Research Society. Dr. Kazakia serves as a reviewer for >10 scientific journals, and she has published numerous peer-reviewed articles and conference abstracts.

    Expertise:
    Musculoskeletal Radiology

    Specialty:
    Musculoskeletal imaging, musculoskeletal diseases, CT, MRI, HR-pQCT, microCT, FTIR

    Professional Interests:
    Mineralization, bone quality, bone architecture, bone micro-damage, biomechanics, mechanical properties, fourier transform infrared (FTIR) spectroscopy, high-resolution computed tomography (CT), fluorescence imaging

    Education and Training:
    • Bachelor of Science: Cornell University, Ithaca, New York - Mechanical Engineering
    • Masters of Science: University of California, Berkeley - Mechanical Engineering
    • Doctor of Philosophy: University of California, Berkeley - Mechanical Engineering

    Collapse Research 
    Collapse Research Activities and Funding
    High Resolution peripheral Quantitative Computed Tomography (HR-pQCT) in vivo human scanner, Scanco Medical AG.
    NIH S10OD021803Jul 1, 2019 - Jun 30, 2020
    Role: Principal Investigator
    Progression and etiology of cortical porosity in diabetic bone disease
    NIH/NIAMS R01AR069670Mar 1, 2017 - Feb 28, 2022
    Role: Principal Investigator
    Bone quality and marrow adiposity in subjects with HIV
    NIH/NIAID R01AI125080Dec 15, 2016 - Nov 30, 2021
    Role: Principal Investigator
    Visualizing Cortical Pore Space Constituents
    NIH/NIAMS R03AR064004Jul 16, 2013 - Jun 30, 2016
    Role: Principal Investigator
    In vivo imaging of cortical porosity in the peripheral skeleton
    NIH/NIAMS K01AR056734Feb 1, 2009 - Nov 30, 2014
    Role: Principal Investigator
    CT &FTIR Assessment of Bone Struture and Composition
    NIH/NIAMS F32AR053446Mar 1, 2006 - Feb 28, 2008
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Foreman SC, Wu PH, Kuang R, John MD, Tien PC, Link TM, Krug R, Kazakia GJ. Factors associated with bone microstructural alterations assessed by HR-pQCT in long-term HIV-infected individuals. Bone. 2019 Dec 21; 115210. PMID: 31874226.
      View in: PubMed
    2. Wu PH, Gibbons M, Foreman SC, Carballido-Gamio J, Han M, Krug R, Liu J, Link TM, Kazakia GJ. Cortical bone vessel identification and quantification on contrast-enhanced MR images. Quant Imaging Med Surg. 2019 Jun; 9(6):928-941. PMID: 31367547.
      View in: PubMed
    3. Huang HC, Srinivasan R, Sun Y, Kazakia GJ, Lin PC, Yeh BM. Detection of Lumbar Spine Osseous Metastases Using Dual-Energy CT: Phantom Results and Preliminary Clinical Validation. AJR Am J Roentgenol. 2019 02; 212(2):402-410. PMID: 30667316.
      View in: PubMed
    4. Bucknor MD, Goel H, Pasco C, Horvai AE, Kazakia GJ. Bone remodeling following MR-guided focused ultrasound: Evaluation with HR-pQCT and FTIR. Bone. 2019 03; 120:347-353. PMID: 30453088.
      View in: PubMed
    5. Berg-Johansen B, Han M, Fields AJ, Liebenberg EC, Lim BJ, Larson PE, Gunduz-Demir C, Kazakia GJ, Krug R, Lotz JC. Cartilage Endplate Thickness Variation Measured by Ultrashort Echo-Time MRI Is Associated With Adjacent Disc Degeneration. Spine (Phila Pa 1976). 2018 05 15; 43(10):E592-E600. PMID: 28984733.
      View in: PubMed
    6. Sundh D, Nilsson M, Zoulakis M, Pasco C, Yilmaz M, Kazakia GJ, Hellgren M, Lorentzon M. High-Impact Mechanical Loading Increases Bone Material Strength in Postmenopausal Women-A 3-Month Intervention Study. J Bone Miner Res. 2018 07; 33(7):1242-1251. PMID: 29578618.
      View in: PubMed
    7. Schafer AL, Kazakia GJ, Vittinghoff E, Stewart L, Rogers SJ, Kim TY, Carter JT, Posselt AM, Pasco C, Shoback DM, Black DM. Effects of Gastric Bypass Surgery on Bone Mass and Microarchitecture Occur Early and Particularly Impact Postmenopausal Women. J Bone Miner Res. 2018 06; 33(6):975-986. PMID: 29281126.
      View in: PubMed
    8. Kazakia GJ, Carballido-Gamio J, Lai A, Nardo L, Facchetti L, Pasco C, Zhang CA, Han M, Parrott AH, Tien P, Krug R. Trabecular bone microstructure is impaired in the proximal femur of human immunodeficiency virus-infected men with normal bone mineral density. Quant Imaging Med Surg. 2018 Feb; 8(1):5-13. PMID: 29541618.
      View in: PubMed
    9. Ford AC, Chui WF, Zeng AY, Nandy A, Liebenberg E, Carraro C, Kazakia G, Alliston T, O'Connell GD. A modular approach to creating large engineered cartilage surfaces. J Biomech. 2018 01 23; 67:177-183. PMID: 29273221.
      View in: PubMed
    10. Millard SM, Wang L, Wattanachanya L, O'Carroll D, Fields AJ, Pang J, Kazakia G, Lotz JC, Nissenson RA. Role of Osteoblast Gi Signaling in Age-Related Bone Loss in Female Mice. Endocrinology. 2017 06 01; 158(6):1715-1726. PMID: 28407060.
      View in: PubMed
    11. Carballido-Gamio J, Bonaretti S, Kazakia GJ, Khosla S, Majumdar S, Lang TF, Burghardt AJ. Statistical Parametric Mapping of HR-pQCT Images: A Tool for Population-Based Local Comparisons of Micro-Scale Bone Features. Ann Biomed Eng. 2017 04; 45(4):949-962. PMID: 27830488.
      View in: PubMed
    12. Heilmeier U, Cheng K, Pasco C, Parrish R, Nirody J, Patsch JM, Zhang CA, Joseph GB, Burghardt AJ, Schwartz AV, Link TM, Kazakia G. Cortical bone laminar analysis reveals increased midcortical and periosteal porosity in type 2 diabetic postmenopausal women with history of fragility fractures compared to fracture-free diabetics. Osteoporos Int. 2016 09; 27(9):2791-2802. PMID: 27154435.
      View in: PubMed
    13. Gibbons RS, Beaupre GS, Kazakia GJ. FES-rowing attenuates bone loss following spinal cord injury as assessed by HR-pQCT. Spinal Cord Ser Cases. 2016; 2:15041. PMID: 28053743.
      View in: PubMed
    14. Mohan G, Magnitsky S, Melkus G, Subburaj K, Kazakia G, Burghardt AJ, Dang A, Lane NE, Majumdar S. Kartogenin treatment prevented joint degeneration in a rodent model of osteoarthritis: A pilot study. J Orthop Res. 2016 10; 34(10):1780-1789. PMID: 26895619.
      View in: PubMed
    15. Wang J, Kazakia GJ, Zhou B, Shi XT, Guo XE. Distinct Tissue Mineral Density in Plate- and Rod-like Trabeculae of Human Trabecular Bone. J Bone Miner Res. 2015 Sep; 30(9):1641-50. PMID: 25736715.
      View in: PubMed
    16. Nirody JA, Cheng KP, Parrish RM, Burghardt AJ, Majumdar S, Link TM, Kazakia GJ. Spatial distribution of intracortical porosity varies across age and sex. Bone. 2015 Jun; 75:88-95. PMID: 25701139.
      View in: PubMed
    17. Kaynia N, Soohoo E, Keaveny TM, Kazakia GJ. Effect of intraspecimen spatial variation in tissue mineral density on the apparent stiffness of trabecular bone. J Biomech Eng. 2015 Jan; 137(1). PMID: 25412197.
      View in: PubMed
    18. Gee CS, Nguyen JT, Marquez CJ, Heunis J, Lai A, Wyatt C, Han M, Kazakia G, Burghardt AJ, Karampinos DC, Carballido-Gamio J, Krug R. Validation of bone marrow fat quantification in the presence of trabecular bone using MRI. J Magn Reson Imaging. 2015 Aug; 42(2):539-44. PMID: 25425074.
      View in: PubMed
    19. Julio Carballido-Gamio, Serena Bonaretti, Galateia J. Kazakia, Sundeep Khosla, Thomas F. Lang, Andrew J. Burghardt. Population-based local multi-parametric comparisons of HR-pQCT studies. Journal of Orthopaedic Translation. 2014 Oct 1; 2(4):234-235.
      View in: Publisher Site
    20. Carriero A, Zimmermann EA, Paluszny A, Tang SY, Bale H, Busse B, Alliston T, Kazakia G, Ritchie RO, Shefelbine SJ. How tough is brittle bone? Investigating osteogenesis imperfecta in mouse bone. J Bone Miner Res. 2014 Jun; 29(6):1392-1401. PMID: 24420672.
      View in: PubMed
    21. Kazakia GJ, Tjong W, Nirody JA, Burghardt AJ, Carballido-Gamio J, Patsch JM, Link T, Feeley BT, Ma CB. The influence of disuse on bone microstructure and mechanics assessed by HR-pQCT. Bone. 2014 Jun; 63:132-40. PMID: 24603002.
      View in: PubMed
    22. Hesse B, Langer M, Varga P, Pacureanu A, Dong P, Schrof S, Männicke N, Suhonen H, Olivier C, Maurer P, Kazakia GJ, Raum K, Peyrin F. Alterations of mass density and 3D osteocyte lacunar properties in bisphosphonate-related osteonecrotic human jaw bone, a synchrotron µCT study. PLoS One. 2014; 9(2):e88481. PMID: 24586331.
      View in: PubMed
    23. Tjong W, Nirody J, Burghardt AJ, Carballido-Gamio J, Kazakia GJ. Structural analysis of cortical porosity applied to HR-pQCT data. Med Phys. 2014 Jan; 41(1):013701. PMID: 24387533.
      View in: PubMed
    24. Burghardt AJ, Pialat JB, Kazakia GJ, Boutroy S, Engelke K, Patsch JM, Valentinitsch A, Liu D, Szabo E, Bogado CE, Zanchetta MB, McKay HA, Shane E, Boyd SK, Bouxsein ML, Chapurlat R, Khosla S, Majumdar S. Multicenter precision of cortical and trabecular bone quality measures assessed by high-resolution peripheral quantitative computed tomography. J Bone Miner Res. 2013 Mar; 28(3):524-36. PMID: 23074145.
      View in: PubMed
    25. Kazakia GJ, Nirody JA, Bernstein G, Sode M, Burghardt AJ, Majumdar S. Age- and gender-related differences in cortical geometry and microstructure: Improved sensitivity by regional analysis. Bone. 2013 Feb; 52(2):623-31. PMID: 23142360.
      View in: PubMed
    26. Lu C, Saless N, Wang X, Sinha A, Decker S, Kazakia G, Hou H, Williams B, Swartz HM, Hunt TK, Miclau T, Marcucio RS. The role of oxygen during fracture healing. Bone. 2013 Jan; 52(1):220-9. PMID: 23063782.
      View in: PubMed
    27. Kazakia GJ, Kuo D, Schooler J, Siddiqui S, Shanbhag S, Bernstein G, Horvai A, Majumdar S, Ries M, Li X. Bone and cartilage demonstrate changes localized to bone marrow edema-like lesions within osteoarthritic knees. Osteoarthritis Cartilage. 2013 Jan; 21(1):94-101. PMID: 23025926.
      View in: PubMed
    28. Tjong W, Kazakia GJ, Burghardt AJ, Majumdar S. The effect of voxel size on high-resolution peripheral computed tomography measurements of trabecular and cortical bone microstructure. Med Phys. 2012 Apr; 39(4):1893-903. PMID: 22482611.
      View in: PubMed
    29. Patsch JM, Burghardt AJ, Kazakia G, Majumdar S. Noninvasive imaging of bone microarchitecture. Ann N Y Acad Sci. 2011 Dec; 1240:77-87. PMID: 22172043.
      View in: PubMed
    30. A.J. Burghardt, G.J. Kazakia?, T.M. Link, S. Majumdar. Age-related differences in cortico-trabecular connectivity and load transfer in the distal radius measured in vivo by HR-pQCT. Bone. 2011 May 1; 48:s174.
      View in: Publisher Site
    31. W. Tjong, M. Sode, A. Burghardt, S. Majumdar, B. Feeley, B. Ma, G. Kazakia. Longitudinal in vivo HR-pQCT assessment of the influence of non-weight bearing on bone quality. Bone. 2011 May 1; 48:s184.
      View in: Publisher Site
    32. Kazakia GJ, Speer D, Shanbhag S, Majumdar S, Conklin BR, Nissenson RA, Hsiao EC. Mineral composition is altered by osteoblast expression of an engineered G(s)-coupled receptor. Calcif Tissue Int. 2011 Jul; 89(1):10-20. PMID: 21526395.
      View in: PubMed
    33. Kazakia GJ, Burghardt AJ, Link TM, Majumdar S. Variations in morphological and biomechanical indices at the distal radius in subjects with identical BMD. J Biomech. 2011 Jan 11; 44(2):257-66. PMID: 21071031.
      View in: PubMed
    34. Folkesson J, Goldenstein J, Carballido-Gamio J, Kazakia G, Burghardt AJ, Rodriguez A, Krug R, de Papp AE, Link TM, Majumdar S. Longitudinal evaluation of the effects of alendronate on MRI bone microarchitecture in postmenopausal osteopenic women. Bone. 2011 Mar 01; 48(3):611-21. PMID: 21059422.
      View in: PubMed
    35. Burghardt AJ, Kazakia GJ, Sode M, de Papp AE, Link TM, Majumdar S. A longitudinal HR-pQCT study of alendronate treatment in postmenopausal women with low bone density: Relations among density, cortical and trabecular microarchitecture, biomechanics, and bone turnover. J Bone Miner Res. 2010 Dec; 25(12):2558-71. PMID: 20564242.
      View in: PubMed
    36. Burghardt AJ, Kazakia GJ, Ramachandran S, Link TM, Majumdar S. Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia. J Bone Miner Res. 2010 May; 25(5):983-93. PMID: 19888900.
      View in: PubMed
    37. Sode M, Burghardt AJ, Kazakia GJ, Link TM, Majumdar S. Regional variations of gender-specific and age-related differences in trabecular bone structure of the distal radius and tibia. Bone. 2010 Jun; 46(6):1652-60. PMID: 20188877.
      View in: PubMed
    38. Goldenstein J, Kazakia G, Majumdar S. In vivo evaluation of the presence of bone marrow in cortical porosity in postmenopausal osteopenic women. Ann Biomed Eng. 2010 Feb; 38(2):235-46. PMID: 19953321.
      View in: PubMed
    39. Slyfield CR, Niemeyer KE, Tkachenko EV, Tomlinson RE, Steyer GG, Patthanacharoenphon CG, Kazakia GJ, Wilson DL, Hernandez CJ. Three-dimensional surface texture visualization of bone tissue through epifluorescence-based serial block face imaging. J Microsc. 2009 Oct; 236(1):52-9. PMID: 19772536.
      View in: PubMed
    40. G.J. Kazakia, D. Kuo, J. Schooler, S. Shanbhag, S. Majumdar, M. Ries, X. Li. 392 BONE MARROW EDEMA-LIKE LESIONS IN OSTEOARTHRITIC SUBJECTS EXHIBIT ALTERED TRABECULAR STRUCTURE AND COMPOSITION. Osteoarthritis and Cartilage. 2009 Sep 1; 17:s206-s207.
      View in: Publisher Site
    41. Issever AS, Link TM, Kentenich M, Rogalla P, Burghardt AJ, Kazakia GJ, Majumdar S, Diederichs G. Assessment of trabecular bone structure using MDCT: comparison of 64- and 320-slice CT using HR-pQCT as the reference standard. Eur Radiol. 2010 Feb; 20(2):458-68. PMID: 19711081.
      View in: PubMed
    42. Sekhon K, Kazakia GJ, Burghardt AJ, Hermannsson B, Majumdar S. Accuracy of volumetric bone mineral density measurement in high-resolution peripheral quantitative computed tomography. Bone. 2009 Sep; 45(3):473-9. PMID: 19501201.
      View in: PubMed
    43. Burghardt AJ, Kazakia GJ, Link TM, Majumdar S. Automated simulation of areal bone mineral density assessment in the distal radius from high-resolution peripheral quantitative computed tomography. Osteoporos Int. 2009 Dec; 20(12):2017-24. PMID: 19330422.
      View in: PubMed
    44. Burghardt AJ, Kazakia GJ, Laib A, Majumdar S. Quantitative assessment of bone tissue mineralization with polychromatic micro-computed tomography. Calcif Tissue Int. 2008 Aug; 83(2):129-38. PMID: 18685797.
      View in: PubMed
    45. Kazakia GJ, Burghardt AJ, Cheung S, Majumdar S. Assessment of bone tissue mineralization by conventional x-ray microcomputed tomography: comparison with synchrotron radiation microcomputed tomography and ash measurements. Med Phys. 2008 Jul; 35(7):3170-9. PMID: 18697542.
      View in: PubMed
    46. Kazakia GJ, Hyun B, Burghardt AJ, Krug R, Newitt DC, de Papp AE, Link TM, Majumdar S. In vivo determination of bone structure in postmenopausal women: a comparison of HR-pQCT and high-field MR imaging. J Bone Miner Res. 2008 Apr; 23(4):463-74. PMID: 18052756.
      View in: PubMed
    47. Krug R, Carballido-Gamio J, Burghardt AJ, Kazakia G, Hyun BH, Jobke B, Banerjee S, Huber M, Link TM, Majumdar S. Assessment of trabecular bone structure comparing magnetic resonance imaging at 3 Tesla with high-resolution peripheral quantitative computed tomography ex vivo and in vivo. Osteoporos Int. 2008 May; 19(5):653-61. PMID: 17992467.
      View in: PubMed
    48. Bigley RF, Singh M, Hernandez CJ, Kazakia GJ, Martin RB, Keaveny TM. Validity of serial milling-based imaging system for microdamage quantification. Bone. 2008 Jan; 42(1):212-5. PMID: 17951125.
      View in: PubMed
    49. Burghardt AJ, Kazakia GJ, Majumdar S. A local adaptive threshold strategy for high resolution peripheral quantitative computed tomography of trabecular bone. Ann Biomed Eng. 2007 Oct; 35(10):1678-86. PMID: 17602299.
      View in: PubMed
    50. Kazakia GJ, Lee JJ, Singh M, Bigley RF, Martin RB, Keaveny TM. Automated high-resolution three-dimensional fluorescence imaging of large biological specimens. J Microsc. 2007 Feb; 225(Pt 2):109-17. PMID: 17359245.
      View in: PubMed
    51. Kazakia GJ, Nauman EA, Ebenstein DM, Halloran BP, Keaveny TM. Effects of in vitro bone formation on the mechanical properties of a trabeculated hydroxyapatite bone substitute. J Biomed Mater Res A. 2006 Jun 15; 77(4):688-99. PMID: 16514602.
      View in: PubMed
    52. Kazakia GJ, Majumdar S. New imaging technologies in the diagnosis of osteoporosis. Rev Endocr Metab Disord. 2006 Jun; 7(1-2):67-74. PMID: 17043763.
      View in: PubMed
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