Alfred Kuo, MD, PhD

Title(s)Professor, Orthopaedic Surgery
SchoolSchool of Medicine
Address1500 Owens Street, #123
San Francisco CA 94158
Phone415-221-4810 ext. 3259
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoM.D.2000 Medicine
    University of California, San FranciscoPh.D.1997 Graduate Division (Medicine)
    University of California, San Francisco, CA2019Diversity, Equity, and Inclusion Champion Training

    Collapse Overview 
    Collapse Overview
    Dr. Kuo practices orthopaedic surgery, teaches, and performs research at the San Francisco Veterans Affairs Medical Center. His clinical focus is total joint replacement. He is interested in creating new treatments for orthopedic disorders as well as improving the outcomes of orthopaedic treatments. He holds leadership positions locally, regionally, and nationally within the Department of Veterans Affairs.

    Collapse Research 
    Collapse Research Activities and Funding
    Development and Validation of a Risk Calculator for Total Joint Replacement
    NIH I01HX001260Feb 1, 2015 - Sep 30, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Tool to Estimate Risk of 30-day Mortality and Complications After Hip Fracture Surgery: Accurate Enough for Some but Not All Purposes? A Study From the ACS-NSQIP Database. Clin Orthop Relat Res. 2022 12 01; 480(12):2335-2346. Harris AHS, Trickey AW, Eddington HS, Seib CD, Kamal RN, Kuo AC, Ding Q, Giori NJ. PMID: 35901441; PMCID: PMC10538935.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    2. What Factors Lead to Racial Disparities in Outcomes After Total Knee Arthroplasty? J Racial Ethn Health Disparities. 2022 Dec; 9(6):2317-2322. Hu DA, Hu JB, Lee A, Rubenstein WJ, Hwang KM, Ibrahim SA, Kuo AC. PMID: 34642904; PMCID: PMC9633442.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    3. Hepatitis C infection and complication rates after total shoulder arthroplasty in United States veterans. JSES Int. 2021 Jul; 5(4):699-706. Su F, Cogan CJ, Bendich I, Zhang N, Whooley MA, Kuo AC. PMID: 34223418; PMCID: PMC8245977.
      View in: PubMed   Mentions: 2  
    4. Antibiotic-Laden Bone Cement Use and Revision Risk After Primary Total Knee Arthroplasty in U.S. Veterans. J Bone Joint Surg Am. 2020 Nov 18; 102(22):1939-1947. Bendich I, Zhang N, Barry JJ, Ward DT, Whooley MA, Kuo AC. PMID: 32890041.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    5. Can Machine Learning Methods Produce Accurate and Easy-to-Use Preoperative Prediction Models of One-Year Improvements in Pain and Functioning After Knee Arthroplasty? J Arthroplasty. 2021 01; 36(1):112-117.e6. Harris AHS, Kuo AC, Bowe TR, Manfredi L, Lalani NF, Giori NJ. PMID: 32798181.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    6. Social Determinants of Health and Patient-Reported Outcomes Following Total Hip and Knee Arthroplasty in Veterans. J Arthroplasty. 2020 09; 35(9):2357-2362. Rubenstein WJ, Harris AHS, Hwang KM, Giori NJ, Kuo AC. PMID: 32498969.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    7. Comparing Methods to Determine the Minimal Clinically Important Differences in Patient-Reported Outcome Measures for Veterans Undergoing Elective Total Hip or Knee Arthroplasty in Veterans Health Administration Hospitals. JAMA Surg. 2020 05 01; 155(5):404-411. Kuo AC, Giori NJ, Bowe TR, Manfredi L, Lalani NF, Nordin DA, Harris AHS. PMID: 32211842; PMCID: PMC7097846.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    8. Comparison of Periarticular Infiltration and Combination Delivery of Local Anesthetics for Reducing Pain and Opioid Consumption after Total Knee Arthroplasty. J Knee Surg. 2021 Sep; 34(11):1149-1154. Ward DT, Grotkopp E, Detch RC, Kim HT, Kuo AC. PMID: 32143218.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. Does Implant Choice Affect the Episode Cost of Pertrochanteric Hip Fracture for US Veterans? J Orthop Trauma. 2019 Dec; 33(12):635-641. Patterson JT, Takemoto SK, Shearer DW, Kuo AC. PMID: 31425414.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis. Bone Res. 2019; 7:34. Mazur CM, Woo JJ, Yee CS, Fields AJ, Acevedo C, Bailey KN, Kaya S, Fowler TW, Lotz JC, Dang A, Kuo AC, Vail TP, Alliston T. PMID: 31700695; PMCID: PMC6828661.
      View in: PubMed   Mentions: 41  
    11. Preoperative Treatment of Hepatitis C Is Associated With Lower Prosthetic Joint Infection Rates in US Veterans. J Arthroplasty. 2019 Jul; 34(7S):S319-S326.e1. Bendich I, Takemoto S, Patterson JT, Monto A, Barber TC, Kuo AC. PMID: 30930157.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    12. Can Machine Learning Methods Produce Accurate and Easy-to-use Prediction Models of 30-day Complications and Mortality After Knee or Hip Arthroplasty? Clin Orthop Relat Res. 2019 02; 477(2):452-460. Harris AHS, Kuo AC, Weng Y, Trickey AW, Bowe T, Giori NJ. PMID: 30624314; PMCID: PMC6370104.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    13. Freedom From Opioids After Total Knee Arthroplasty. J Arthroplasty. 2019 05; 34(5):893-897. Kuo AC, Raghunathan K, Lartigue AM, Bryan WE, Pepin MJ, Takemoto S, Wallace AW. PMID: 30777627.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    14. Repurposing Human Osteoarthritic Cartilage as a Bone Graft Substitute in an Athymic Rat Posterolateral Spinal Fusion Model. Int J Spine Surg. 2018 Dec; 12(6):735-742. Dang ABC, Hong H, Lee K, Luan T, Reddy S, Kuo AC. PMID: 30619678; PMCID: PMC6314337.
      View in: PubMed   Mentions: 3  
    15. Acute Pain Is Associated With Chronic Opioid Use After Total Knee Arthroplasty. Reg Anesth Pain Med. 2018 Oct; 43(7):705-711. Hsia HL, Takemoto S, van de Ven T, Pyati S, Buchheit T, Ray N, Wellman S, Kuo A, Wallace A, Raghunathan K. PMID: 29975257; PMCID: PMC6319560.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    16. American Joint Replacement Registry Risk Calculator Does Not Predict 90-day Mortality in Veterans Undergoing Total Joint Replacement. Clin Orthop Relat Res. 2018 09; 476(9):1869-1875. Harris AHS, Kuo AC, Bozic KJ, Lau E, Bowe T, Gupta S, Giori NJ. PMID: 30113939; PMCID: PMC6259803.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    17. Prediction Models for 30-Day Mortality and Complications After Total Knee and Hip Arthroplasties for Veteran Health Administration Patients With Osteoarthritis. J Arthroplasty. 2018 05; 33(5):1539-1545. Harris AH, Kuo AC, Bowe T, Gupta S, Nordin D, Giori NJ. PMID: 29398261; PMCID: PMC6508537.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    18. A Simple Method Associated With Reduced Opioid Consumption After Total Knee Arthroplasty. J Arthroplasty. 2017 10; 32(10):3034-3037. Kuo AC, Grotkopp E. PMID: 28634091.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. The Effects of Topical Vancomycin on Mesenchymal Stem Cells: More May Not Be Better. Int J Spine Surg. 2017; 11:12. Chu S, Chen N, Dang ABC, Kuo AC, Dang ABC. PMID: 28765796; PMCID: PMC5537948.
      View in: PubMed   Mentions: 8  
    20. Preoperative Anemia Independently Predicts 30-Day Complications After Aseptic and Septic Revision Total Joint Arthroplasty. J Arthroplasty. 2017 09; 32(9S):S197-S201. Lu M, Sing DC, Kuo AC, Hansen EN. PMID: 28390884.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    21. Promoting Endochondral Bone Repair Using Human Osteoarthritic Articular Chondrocytes. Tissue Eng Part A. 2016 Mar; 22(5-6):427-35. Bahney CS, Jacobs L, Tamai R, Hu D, Luan TF, Wang M, Reddy S, Park M, Limburg S, Kim HT, Marcucio R, Kuo AC. PMID: 26830207; PMCID: PMC4800268.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    22. Costs and Complications of Short Versus Long Cephalomedullary Nailing of OTA 31-A2 Proximal Femur Fractures in U.S. Veterans. J Orthop Trauma. 2016 Mar; 30(3):125-9. Krigbaum H, Takemoto S, Kim HT, Kuo AC. PMID: 26894639.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    23. Complications of Morbid Obesity in Total Joint Arthroplasty: Risk Stratification Based on BMI. J Arthroplasty. 2015 Sep; 30(9 Suppl):42-6. Ward DT, Metz LN, Horst PK, Kim HT, Kuo AC. PMID: 26117070.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    24. Trophic stimulation of articular chondrocytes by late-passage mesenchymal stem cells in coculture. J Orthop Res. 2013 Dec; 31(12):1936-42. Wang M, Rahnama R, Cheng T, Grotkopp E, Jacobs L, Limburg S, Kim HT, Kuo AC. PMID: 24038580.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    25. Mid-term outcomes in HIV-positive patients after primary total hip or knee arthroplasty. J Arthroplasty. 2014 Feb; 29(2):277-82. Lin CA, Takemoto S, Kandemir U, Kuo AC. PMID: 23867663.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    26. Peripheral nerve repair in rats using composite hydrogel-filled aligned nanofiber conduits with incorporated nerve growth factor. Tissue Eng Part A. 2013 Oct; 19(19-20):2138-46. Jin J, Limburg S, Joshi SK, Landman R, Park M, Zhang Q, Kim HT, Kuo AC. PMID: 23659607; PMCID: PMC3761439.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    27. Comorbidities and perioperative complications in HIV-positive patients undergoing primary total hip and knee arthroplasty. J Bone Joint Surg Am. 2013 Jun 05; 95(11):1028-36. Lin CA, Kuo AC, Takemoto S. PMID: 23780541.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    28. Cytotoxicity of local anesthetics on human mesenchymal stem cells. J Bone Joint Surg Am. 2013 Jan 16; 95(2):132-7. Rahnama R, Wang M, Dang AC, Kim HT, Kuo AC. PMID: 23324960.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    29. Functional motor recovery after peripheral nerve repair with an aligned nanofiber tubular conduit in a rat model. Regen Med. 2012 Nov; 7(6):799-806. Jin J, Park M, Rengarajan A, Zhang Q, Limburg S, Joshi SK, Patel S, Kim HT, Kuo AC. PMID: 23164080.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    30. Fibroblast growth factor 2 enhances the kinetics of mesenchymal stem cell chondrogenesis. Biochem Biophys Res Commun. 2012 Oct 05; 426(4):544-50. Cheng T, Yang C, Weber N, Kim HT, Kuo AC. PMID: 22982316.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    31. Inducible immortality in hTERT-human mesenchymal stem cells. J Orthop Res. 2012 Dec; 30(12):1879-85. Piper SL, Wang M, Yamamoto A, Malek F, Luu A, Kuo AC, Kim HT. PMID: 22674533.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    32. Comparison of gene expression patterns in articular cartilage and dedifferentiated articular chondrocytes. J Orthop Res. 2012 Feb; 30(2):234-45. Cheng T, Maddox NC, Wong AW, Rahnama R, Kuo AC. PMID: 21809379.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    33. Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy. Osteoarthritis Cartilage. 2011 Oct; 19(10):1210-8. Cooke ME, Allon AA, Cheng T, Kuo AC, Kim HT, Vail TP, Marcucio RS, Schneider RA, Lotz JC, Alliston T. PMID: 21816228; PMCID: PMC3188316.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    34. In situ Materials Characterization using the Tissue Diagnostic Instrument. Polym Test. 2010 Apr 01; 29(2):159-163. Tang SY, Mathews P, Randall C, Yurtsev E, Fields K, Wong A, Kuo A, Alliston T, Hansma P. PMID: 20582333; PMCID: PMC2891070.
      View in: PubMed   Mentions: 3  
    35. The tissue diagnostic instrument. Rev Sci Instrum. 2009 May; 80(5):054303. Hansma P, Yu H, Schultz D, Rodriguez A, Yurtsev EA, Orr J, Tang S, Miller J, Wallace J, Zok F, Li C, Souza R, Proctor A, Brimer D, Nogues-Solan X, Mellbovsky L, Peña MJ, Diez-Ferrer O, Mathews P, Randall C, Kuo A, Chen C, Peters M, Kohn D, Buckley J, Li X, Pruitt L, Diez-Perez A, Alliston T, Weaver V, Lotz J. PMID: 19485522; PMCID: PMC2832056.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    36. Total hip arthroplasty in rapidly destructive osteoarthritis of the hip: a case series. HSS J. 2009 Sep; 5(2):117-9. Kuo A, Ezzet KA, Patil S, Colwell CW. PMID: 19308645; PMCID: PMC2744750.
      View in: PubMed   Mentions: 13  
    37. Microfracture and bone morphogenetic protein 7 (BMP-7) synergistically stimulate articular cartilage repair. Osteoarthritis Cartilage. 2006 Nov; 14(11):1126-35. Kuo AC, Rodrigo JJ, Reddi AH, Curtiss S, Grotkopp E, Chiu M. PMID: 16765606.
      View in: PubMed   Mentions: 46     Fields:    Translation:Animals
    38. Knee fusion using dual platings with the locking compression plate. J Arthroplasty. 2005 Sep; 20(6):772-6. Kuo AC, Meehan JP, Lee M. PMID: 16139715.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    39. Transmembrane transforming growth factor-alpha tethers to the PDZ domain-containing, Golgi membrane-associated protein p59/GRASP55. EMBO J. 2000 Dec 01; 19(23):6427-39. Kuo A, Zhong C, Lane WS, Derynck R. PMID: 11101516; PMCID: PMC305863.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    40. Association of the transmembrane TGF-alpha precursor with a protein kinase complex. J Cell Biol. 1994 May; 125(4):903-16. Shum L, Reeves SA, Kuo AC, Fromer ES, Derynck R. PMID: 8188754; PMCID: PMC2120079.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
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