Hubert Kim, MD, PhD

Title(s)Professor, Orthopaedic Surgery
SchoolSchool of Medicine
Address1500 Owens Street
San Francisco CA 94158
Phone415-476-0561
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine
    Stanford UniversityM.D.1993School of Medicine
    University of California, San Francisco, CA2019Diversity, Equity, and Inclusion Champion Training

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    ShEEP Equipment Request for BD FACSMelody Cell Sorter
    NIH IS1BX005039Sep 1, 2019 - Sep 30, 2020
    Role: Principal Investigator
    TGFb and BMP signaling in muscle atrophy and degradation after massive RCT
    NIH I01BX002680Oct 1, 2015 - Sep 30, 2020
    Role: Principal Investigator
    ECM and MMPs in Muscle Atrophy and Rehabilitation
    NIH I01RX000195Oct 1, 2010 - Sep 30, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Muscle-Derived Beige Adipose Precursors Secrete Promyogenic Exosomes That Treat Rotator Cuff Muscle Degeneration in Mice and Are Identified in Humans by Single-Cell RNA Sequencing. Am J Sports Med. 2022 07; 50(8):2247-2257. Davies MR, Garcia S, Liu M, Chi H, Kim HT, Raffai RL, Liu X, Feeley BT. PMID: 35604307.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Rotator Cuff Tear Size Regulates Fibroadipogenic Progenitor Number and Gene Expression Profile in the Supraspinatus Independent of Patient Age. Am J Sports Med. 2022 01; 50(1):208-215. Davies MR, Chi H, Kaur G, Liu M, Ma CB, Kim HT, Liu X, Feeley BT. PMID: 34779676; PMCID: PMC9280916.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Microenergy acoustic pulses promotes muscle regeneration through in situ activation of muscle stem cells. J Orthop Res. 2022 07; 40(7):1621-1631. Zhang H, Kim HT, Feeley BT, Lin G, Lue TF, Liu M, Banie L, Liu X. PMID: 34657315; PMCID: PMC9013392.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Preconditioning improves muscle regeneration after ischemia-reperfusion injury. J Orthop Res. 2021 09; 39(9):1889-1897. Zhang H, Liu M, Kim HT, Feeley BT, Liu X. PMID: 33232533; PMCID: PMC9257970.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    5. Rotator cuff tear degeneration and the role of fibro-adipogenic progenitors. Ann N Y Acad Sci. 2021 04; 1490(1):13-28. Agha O, Diaz A, Davies M, Kim HT, Liu X, Feeley BT. PMID: 32725671; PMCID: PMC7855559.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. Intervertebral disc herniation effects on multifidus muscle composition and resident stem cell populations. JOR Spine. 2020 Jun; 3(2):e1091. Agha O, Mueller-Immergluck A, Liu M, Zhang H, Theologis AA, Clark A, Kim HT, Liu X, Feeley BT, Bailey JF. PMID: 32613166; PMCID: PMC7323461.
      View in: PubMed   Mentions: 4  
    7. Beige FAPs Transplantation Improves Muscle Quality and Shoulder Function After Massive Rotator Cuff Tears. J Orthop Res. 2020 05; 38(5):1159-1166. Lee C, Liu M, Agha O, Kim HT, Feeley BT, Liu X. PMID: 31808573; PMCID: PMC7162719.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    8. Rotator Cuff Fibro-Adipogenic Progenitors Demonstrate Highest Concentration, Proliferative Capacity, and Adipogenic Potential Across Muscle Groups. J Orthop Res. 2020 05; 38(5):1113-1121. Lee C, Agha O, Liu M, Davies M, Bertoy L, Kim HT, Liu X, Feeley BT. PMID: 31799698; PMCID: PMC9262119.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    9. Beige fibro-adipogenic progenitor transplantation reduces muscle degeneration and improves function in a mouse model of delayed repair of rotator cuff tears. J Shoulder Elbow Surg. 2020 Apr; 29(4):719-727. Lee C, Liu M, Agha O, Kim HT, Liu X, Feeley BT. PMID: 31784382; PMCID: PMC7085983.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    10. Reversal of Fatty Infiltration After Suprascapular Nerve Compression Release Is Dependent on UCP1 Expression in Mice. Clin Orthop Relat Res. 2018 08; 476(8):1665-1679. Wang Z, Feeley BT, Kim HT, Liu X. PMID: 30020151; PMCID: PMC6259770.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    11. Knocking-out matrix metalloproteinase-13 exacerbates rotator cuff muscle fatty infiltration. Muscles Ligaments Tendons J. 2017 Apr-Jun; 7(2):202-207. Liu X, Ravishankar B, Ning A, Liu M, Kim HT, Feeley BT. PMID: 29264329; PMCID: PMC5725167.
      View in: PubMed   Mentions: 3  
    12. Lysophosphatidic acid-induced RhoA signaling and prolonged macrophage infiltration worsens fibrosis and fatty infiltration following rotator cuff tears. J Orthop Res. 2017 07; 35(7):1539-1547. Davies MR, Lee L, Feeley BT, Kim HT, Liu X. PMID: 27505847; PMCID: PMC5502767.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    13. TGF-β Small Molecule Inhibitor SB431542 Reduces Rotator Cuff Muscle Fibrosis and Fatty Infiltration By Promoting Fibro/Adipogenic Progenitor Apoptosis. PLoS One. 2016; 11(5):e0155486. Davies MR, Liu X, Lee L, Laron D, Ning AY, Kim HT, Feeley BT. PMID: 27186977; PMCID: PMC4871364.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    14. Promoting Endochondral Bone Repair Using Human Osteoarthritic Articular Chondrocytes. Tissue Eng Part A. 2016 Mar; 22(5-6):427-35. Bahney CS, Jacobs L, Tamai R, Hu D, Luan TF, Wang M, Reddy S, Park M, Limburg S, Kim HT, Marcucio R, Kuo AC. PMID: 26830207; PMCID: PMC4800268.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    15. Costs and Complications of Short Versus Long Cephalomedullary Nailing of OTA 31-A2 Proximal Femur Fractures in U.S. Veterans. J Orthop Trauma. 2016 Mar; 30(3):125-9. Krigbaum H, Takemoto S, Kim HT, Kuo AC. PMID: 26894639.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    16. Novel intracellular N-terminal truncated matrix metalloproteinase-2 isoform in skeletal muscle ischemia-reperfusion injury. J Orthop Res. 2016 Mar; 34(3):502-9. Joshi SK, Lee L, Lovett DH, Kang H, Kim HT, Delgado C, Liu X. PMID: 26213293.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    17. Bone morphogenetic protein signaling in rotator cuff muscle atrophy and fatty infiltration. Muscles Ligaments Tendons J. 2015 Apr-Jun; 5(2):113-9. Liu X, Joshi S, Ravishankar B, Laron D, Kim HT, Feeley BT. PMID: 26261790; PMCID: PMC4496010.
      View in: PubMed   Mentions: 6  
    18. Rat rotator cuff muscle responds differently from hindlimb muscle to a combined tendon-nerve injury. J Orthop Res. 2015 Jul; 33(7):1046-53. Davies MR, Ravishankar B, Laron D, Kim HT, Liu X, Feeley BT. PMID: 25974842.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    19. Matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy. Muscles Ligaments Tendons J. 2014 Oct-Dec; 4(4):446-54. Zhang Q, Joshi SK, Lovett DH, Zhang B, Bodine S, Kim HT, Liu X. PMID: 25767782; PMCID: PMC4327354.
      View in: PubMed   Mentions: 12  
    20. Upregulation of transforming growth factor-β signaling in a rat model of rotator cuff tears. J Shoulder Elbow Surg. 2014 Nov; 23(11):1709-16. Liu X, Joshi SK, Ravishankar B, Laron D, Kim HT, Feeley BT. PMID: 24875732; PMCID: PMC4198422.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    21. Novel mouse model of spinal cord injury-induced heterotopic ossification. J Rehabil Res Dev. 2014; 51(7):1109-18. Kang H, Dang AB, Joshi SK, Halloran B, Nissenson R, Zhang X, Li J, Kim HT, Liu X. PMID: 25436890.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    22. Joint instability and cartilage compression in a mouse model of posttraumatic osteoarthritis. J Orthop Res. 2014 Feb; 32(2):318-23. Onur TS, Wu R, Chu S, Chang W, Kim HT, Dang AB. PMID: 24167068; PMCID: PMC4462343.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    23. Differential ubiquitin-proteasome and autophagy signaling following rotator cuff tears and suprascapular nerve injury. J Orthop Res. 2014 Jan; 32(1):138-44. Joshi SK, Kim HT, Feeley BT, Liu X. PMID: 24018537; PMCID: PMC3856942.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    24. Trophic stimulation of articular chondrocytes by late-passage mesenchymal stem cells in coculture. J Orthop Res. 2013 Dec; 31(12):1936-42. Wang M, Rahnama R, Cheng T, Grotkopp E, Jacobs L, Limburg S, Kim HT, Kuo AC. PMID: 24038580.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    25. Original article Muscle extracellular matrix degradation and contractibility following tendon rupture and disuse. Muscles Ligaments Tendons J. 2013 Jan; 3(1):35-41. Zhang Q, Joshi SK, Manzano G, Lovett DH, Kim HT, Liu X. PMID: 23885343; PMCID: PMC3676162.
      View in: PubMed   Mentions: 7  
    26. Evaluation of cartilage degeneration in a rat model of rotator cuff tear arthropathy. J Shoulder Elbow Surg. 2013 Dec; 22(12):1702-9. Kramer EJ, Bodendorfer BM, Laron D, Wong J, Kim HT, Liu X, Feeley BT. PMID: 23664745; PMCID: PMC3806888.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    27. Cytotoxicity of local anesthetics on human mesenchymal stem cells. J Bone Joint Surg Am. 2013 Jan 16; 95(2):132-7. Rahnama R, Wang M, Dang AC, Kim HT, Kuo AC. PMID: 23324960.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    28. mTOR regulates fatty infiltration through SREBP-1 and PPARγ after a combined massive rotator cuff tear and suprascapular nerve injury in rats. J Orthop Res. 2013 May; 31(5):724-30. Joshi SK, Liu X, Samagh SP, Lovett DH, Bodine SC, Kim HT, Feeley BT. PMID: 23239524; PMCID: PMC4393845.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    29. Functional motor recovery after peripheral nerve repair with an aligned nanofiber tubular conduit in a rat model. Regen Med. 2012 Nov; 7(6):799-806. Jin J, Park M, Rengarajan A, Zhang Q, Limburg S, Joshi SK, Patel S, Kim HT, Kuo AC. PMID: 23164080.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    30. MRI quantification of fatty infiltration and muscle atrophy in a mouse model of rotator cuff tears. J Orthop Res. 2013 Mar; 31(3):421-6. Samagh SP, Kramer EJ, Melkus G, Laron D, Bodendorfer BM, Natsuhara K, Kim HT, Liu X, Feeley BT. PMID: 22991068.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    31. Fibroblast growth factor 2 enhances the kinetics of mesenchymal stem cell chondrogenesis. Biochem Biophys Res Commun. 2012 Oct 05; 426(4):544-50. Cheng T, Yang C, Weber N, Kim HT, Kuo AC. PMID: 22982316.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    32. Inducible immortality in hTERT-human mesenchymal stem cells. J Orthop Res. 2012 Dec; 30(12):1879-85. Piper SL, Wang M, Yamamoto A, Malek F, Luu A, Kuo AC, Kim HT. PMID: 22674533.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    33. Thermal stress potentiates bupivacaine chondrotoxicity. Arthroscopy. 2012 Sep; 28(9):1246-1254.e1. Piper SL, Kim HT. PMID: 22579775.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    34. A mouse model of massive rotator cuff tears. J Bone Joint Surg Am. 2012 Apr 04; 94(7):e41. Liu X, Laron D, Natsuhara K, Manzano G, Kim HT, Feeley BT. PMID: 22488625.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    35. Evaluation of Akt/mTOR activity in muscle atrophy after rotator cuff tears in a rat model. J Orthop Res. 2012 Sep; 30(9):1440-6. Liu X, Joshi SK, Samagh SP, Dang YX, Laron D, Lovett DH, Bodine SC, Kim HT, Feeley BT. PMID: 22378614.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    36. Muscle degeneration in rotator cuff tears. J Shoulder Elbow Surg. 2012 Feb; 21(2):164-74. Laron D, Samagh SP, Liu X, Kim HT, Feeley BT. PMID: 22244059.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    37. Minocycline reduces articular cartilage damage following osteochondral injury. Knee. 2012 Oct; 19(5):680-3. Yamamoto A, Warren AP, Kim HT. PMID: 22297212.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    38. The in vitro elution characteristics of antifungal-loaded PMMA bone cement and calcium sulfate bone substitute. Orthopedics. 2011 Aug 08; 34(8):e378-81. Grimsrud C, Raven R, Fothergill AW, Kim HT. PMID: 21815580.
      View in: PubMed   Mentions: 12     Fields:    
    39. Effects of local anesthetics on articular cartilage. Am J Sports Med. 2011 Oct; 39(10):2245-53. Piper SL, Kramer JD, Kim HT, Feeley BT. PMID: 21515808.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    40. Effects of mixing techniques on vancomycin-impregnated polymethylmethacrylate. J Arthroplasty. 2011 Dec; 26(8):1562-6. Laine JC, Nguyen TQ, Buckley JM, Kim HT. PMID: 21474275.
      View in: PubMed   Mentions: 5     Fields:    
    41. A rat model of massive rotator cuff tears. J Orthop Res. 2011 Apr; 29(4):588-95. Liu X, Manzano G, Kim HT, Feeley BT. PMID: 20949443.
      View in: PubMed   Mentions: 60     Fields:    Translation:Animals
    42. Role of AP-1 and RE-1 binding sites in matrix metalloproteinase-2 transcriptional regulation in skeletal muscle atrophy. Biochem Biophys Res Commun. 2010 May 28; 396(2):219-23. Liu X, Manzano G, Lovett DH, Kim HT. PMID: 20398633.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    43. Role of gelatinases in disuse-induced skeletal muscle atrophy. Muscle Nerve. 2010 Feb; 41(2):174-8. Liu X, Lee DJ, Skittone LK, Natsuhara K, Kim HT. PMID: 19790245.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    44. Chondrocyte apoptosis after simulated intraarticular fracture: a comparison of histologic detection methods. Clin Orthop Relat Res. 2009 Jul; 467(7):1877-84. Dang AC, Kim HT. PMID: 19363641; PMCID: PMC2690763.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    45. Inhibition of MMP2/MMP9 after spinal cord trauma reduces apoptosis. Spine (Phila Pa 1976). 2008 Aug 01; 33(17):E576-9. Dang AB, Tay BK, Kim HT, Nauth A, Alfonso-Jaume MA, Lovett DH. PMID: 18670324.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    46. Enhancing osteochondral allograft viability: effects of storage media composition. Clin Orthop Relat Res. 2008 Aug; 466(8):1804-9. Teng MS, Yuen AS, Kim HT. PMID: 18506560; PMCID: PMC2584242.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    47. Chondrocyte apoptosis: implications for osteochondral allograft transplantation. Clin Orthop Relat Res. 2008 Aug; 466(8):1819-25. Kim HT, Teng MS, Dang AC. PMID: 18506558; PMCID: PMC2584268.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    48. Matrix metalloproteinase-2 expression and promoter/enhancer activity in skeletal muscle atrophy. J Orthop Res. 2008 Mar; 26(3):357-63. Skittone LK, Liu X, Tseng A, Kim HT. PMID: 17960656.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    49. Preventing chondrocyte programmed cell death caused by iatrogenic injury. Knee. 2007 Mar; 14(2):107-11. Costouros JG, Kim HT. PMID: 17174553.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    50. A peek into the possible future of management of articular cartilage injuries: gene therapy and scaffolds for cartilage repair. J Orthop Sports Phys Ther. 2006 Oct; 36(10):765-73. Kim HT, Zaffagnini S, Mizuno S, Abelow S, Safran MR. PMID: 17063838.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    51. Chondrocyte apoptosis induced by hydrogen peroxide requires caspase activation but not mitochondrial pore transition. J Orthop Res. 2004 Sep; 22(5):1120-5. Lo MY, Kim HT. PMID: 15304288.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    52. Comparison of chondrocyte apoptosis in vivo and in vitro following acute osteochondral injury. J Orthop Res. 2004 May; 22(3):678-83. Costouros JG, Dang AC, Kim HT. PMID: 15099652.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    53. Chondrocyte apoptosis induced by collagen degradation: inhibition by caspase inhibitors and IGF-1. J Orthop Res. 2004 Jan; 22(1):140-4. Lo MY, Kim HT. PMID: 14656672.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
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