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Hubert Kim, MD, PhD

Title(s)Professor, Orthopaedic Surgery
SchoolSchool of Medicine
Phone415-353-9400
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine
    Stanford UniversityM.D.1993School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    TGFb and BMP signaling in muscle atrophy and degradation after massive RCT
    VA I01BX002680Oct 1, 2015 - Sep 30, 2019
    Role: Principal Investigator
    ECM and MMPs in Muscle Atrophy and Rehabilitation
    VA I01RX000195Oct 1, 2010 - Sep 30, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Global Health
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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wang Z, Feeley BT, Kim HT, Liu X. Reversal of Fatty Infiltration After Suprascapular Nerve Compression Release Is Dependent on UCP1 Expression in Mice. Clin Orthop Relat Res. 2018 Aug; 476(8):1665-1679. PMID: 30020151.
      View in: PubMed
    2. Liu X, Ravishankar B, Ning A, Liu M, Kim HT, Feeley BT. Knocking-out matrix metalloproteinase-13 exacerbates rotator cuff muscle fatty infiltration. Muscles Ligaments Tendons J. 2017 Apr-Jun; 7(2):202-207. PMID: 29264329.
      View in: PubMed
    3. Davies MR, Lee L, Feeley BT, Kim HT, Liu X. Lysophosphatidic acid-induced RhoA signaling and prolonged macrophage infiltration worsens fibrosis and fatty infiltration following rotator cuff tears. J Orthop Res. 2017 07; 35(7):1539-1547. PMID: 27505847.
      View in: PubMed
    4. Davies MR, Liu X, Lee L, Laron D, Ning AY, Kim HT, Feeley BT. TGF-ß Small Molecule Inhibitor SB431542 Reduces Rotator Cuff Muscle Fibrosis and Fatty Infiltration By Promoting Fibro/Adipogenic Progenitor Apoptosis. PLoS One. 2016; 11(5):e0155486. PMID: 27186977.
      View in: PubMed
    5. Bahney CS, Jacobs L, Tamai R, Hu D, Luan TF, Wang M, Reddy S, Park M, Limburg S, Kim HT, Marcucio R, Kuo AC. Promoting Endochondral Bone Repair Using Human Osteoarthritic Articular Chondrocytes. Tissue Eng Part A. 2016 Mar; 22(5-6):427-35. PMID: 26830207; PMCID: PMC4800268 [Available on 03/01/17].
      View in: PubMed, PubMed Central
    6. Krigbaum H, Takemoto S, Kim HT, Kuo AC. Costs and Complications of Short Versus Long Cephalomedullary Nailing of OTA 31-A2 Proximal Femur Fractures in U.S. Veterans. J Orthop Trauma. 2016 Mar; 30(3):125-9. PMID: 26894639.
      View in: PubMed
    7. Joshi SK, Lee L, Lovett DH, Kang H, Kim HT, Delgado C, Liu X. Novel intracellular N-terminal truncated matrix metalloproteinase-2 isoform in skeletal muscle ischemia-reperfusion injury. J Orthop Res. 2016 Mar; 34(3):502-9. PMID: 26213293.
      View in: PubMed
    8. Liu X, Joshi S, Ravishankar B, Laron D, Kim HT, Feeley BT. Bone morphogenetic protein signaling in rotator cuff muscle atrophy and fatty infiltration. Muscles Ligaments Tendons J. 2015 Apr-Jun; 5(2):113-9. PMID: 26261790; PMCID: PMC4496010.
      View in: PubMed, PubMed Central
    9. Ward DT, Metz LN, Horst PK, Kim HT, Kuo AC. Complications of Morbid Obesity in Total Joint Arthroplasty: Risk Stratification Based on BMI. J Arthroplasty. 2015 Sep; 30(9 Suppl):42-6. PMID: 26117070.
      View in: PubMed
    10. Davies MR, Ravishankar B, Laron D, Kim HT, Liu X, Feeley BT. Rat rotator cuff muscle responds differently from hindlimb muscle to a combined tendon-nerve injury. J Orthop Res. 2015 Jul; 33(7):1046-53. PMID: 25974842.
      View in: PubMed
    11. Zhang Q, Joshi SK, Lovett DH, Zhang B, Bodine S, Kim HT, Liu X. Matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy. Muscles Ligaments Tendons J. 2014 Oct-Dec; 4(4):446-54. PMID: 25767782; PMCID: PMC4327354.
      View in: PubMed, PubMed Central
    12. Liu X, Joshi SK, Ravishankar B, Laron D, Kim HT, Feeley BT. Upregulation of transforming growth factor-ß signaling in a rat model of rotator cuff tears. J Shoulder Elbow Surg. 2014 Nov; 23(11):1709-16. PMID: 24875732; PMCID: PMC4198422.
      View in: PubMed, PubMed Central
    13. Kang H, Dang AB, Joshi SK, Halloran B, Nissenson R, Zhang X, Li J, Kim HT, Liu X. Novel mouse model of spinal cord injury-induced heterotopic ossification. J Rehabil Res Dev. 2014; 51(7):1109-18. PMID: 25436890.
      View in: PubMed
    14. Onur TS, Wu R, Chu S, Chang W, Kim HT, Dang AB. Joint instability and cartilage compression in a mouse model of posttraumatic osteoarthritis. J Orthop Res. 2014 Feb; 32(2):318-23. PMID: 24167068; PMCID: PMC4462343.
      View in: PubMed, PubMed Central
    15. Joshi SK, Kim HT, Feeley BT, Liu X. Differential ubiquitin-proteasome and autophagy signaling following rotator cuff tears and suprascapular nerve injury. J Orthop Res. 2014 Jan; 32(1):138-44. PMID: 24018537; PMCID: PMC3856942.
      View in: PubMed, PubMed Central
    16. Wang M, Rahnama R, Cheng T, Grotkopp E, Jacobs L, Limburg S, Kim HT, Kuo AC. Trophic stimulation of articular chondrocytes by late-passage mesenchymal stem cells in coculture. J Orthop Res. 2013 Dec; 31(12):1936-42. PMID: 24038580.
      View in: PubMed
    17. Jin J, Limburg S, Joshi SK, Landman R, Park M, Zhang Q, Kim HT, Kuo AC. Peripheral nerve repair in rats using composite hydrogel-filled aligned nanofiber conduits with incorporated nerve growth factor. Tissue Eng Part A. 2013 Oct; 19(19-20):2138-46. PMID: 23659607; PMCID: PMC3761439.
      View in: PubMed, PubMed Central
    18. Zhang Q, Joshi SK, Manzano G, Lovett DH, Kim HT, Liu X. Original article Muscle extracellular matrix degradation and contractibility following tendon rupture and disuse. Muscles Ligaments Tendons J. 2013 Jan; 3(1):35-41. PMID: 23885343; PMCID: PMC3676162.
      View in: PubMed, PubMed Central
    19. Kramer EJ, Bodendorfer BM, Laron D, Wong J, Kim HT, Liu X, Feeley BT. Evaluation of cartilage degeneration in a rat model of rotator cuff tear arthropathy. J Shoulder Elbow Surg. 2013 Dec; 22(12):1702-9. PMID: 23664745; PMCID: PMC3806888.
      View in: PubMed, PubMed Central
    20. Rahnama R, Wang M, Dang AC, Kim HT, Kuo AC. Cytotoxicity of local anesthetics on human mesenchymal stem cells. J Bone Joint Surg Am. 2013 Jan 16; 95(2):132-7. PMID: 23324960.
      View in: PubMed
    21. Joshi SK, Liu X, Samagh SP, Lovett DH, Bodine SC, Kim HT, Feeley BT. mTOR regulates fatty infiltration through SREBP-1 and PPAR? after a combined massive rotator cuff tear and suprascapular nerve injury in rats. J Orthop Res. 2013 May; 31(5):724-30. PMID: 23239524; PMCID: PMC4393845.
      View in: PubMed, PubMed Central
    22. Jin J, Park M, Rengarajan A, Zhang Q, Limburg S, Joshi SK, Patel S, Kim HT, Kuo AC. Functional motor recovery after peripheral nerve repair with an aligned nanofiber tubular conduit in a rat model. Regen Med. 2012 Nov; 7(6):799-806. PMID: 23164080.
      View in: PubMed
    23. Samagh SP, Kramer EJ, Melkus G, Laron D, Bodendorfer BM, Natsuhara K, Kim HT, Liu X, Feeley BT. MRI quantification of fatty infiltration and muscle atrophy in a mouse model of rotator cuff tears. J Orthop Res. 2013 Mar; 31(3):421-6. PMID: 22991068.
      View in: PubMed
    24. Cheng T, Yang C, Weber N, Kim HT, Kuo AC. Fibroblast growth factor 2 enhances the kinetics of mesenchymal stem cell chondrogenesis. Biochem Biophys Res Commun. 2012 Oct 05; 426(4):544-50. PMID: 22982316.
      View in: PubMed
    25. Crawford MD, Kim HT. New-onset synovial chondromatosis after total knee arthroplasty. J Arthroplasty. 2013 Feb; 28(2):375.e1-4. PMID: 22704224.
      View in: PubMed
    26. Piper SL, Wang M, Yamamoto A, Malek F, Luu A, Kuo AC, Kim HT. Inducible immortality in hTERT-human mesenchymal stem cells. J Orthop Res. 2012 Dec; 30(12):1879-85. PMID: 22674533.
      View in: PubMed
    27. Piper SL, Kim HT. Thermal stress potentiates bupivacaine chondrotoxicity. Arthroscopy. 2012 Sep; 28(9):1246-1254.e1. PMID: 22579775.
      View in: PubMed
    28. Liu X, Laron D, Natsuhara K, Manzano G, Kim HT, Feeley BT. A mouse model of massive rotator cuff tears. J Bone Joint Surg Am. 2012 Apr 04; 94(7):e41. PMID: 22488625.
      View in: PubMed
    29. Liu X, Joshi SK, Samagh SP, Dang YX, Laron D, Lovett DH, Bodine SC, Kim HT, Feeley BT. Evaluation of Akt/mTOR activity in muscle atrophy after rotator cuff tears in a rat model. J Orthop Res. 2012 Sep; 30(9):1440-6. PMID: 22378614.
      View in: PubMed
    30. Laron D, Samagh SP, Liu X, Kim HT, Feeley BT. Muscle degeneration in rotator cuff tears. J Shoulder Elbow Surg. 2012 Feb; 21(2):164-74. PMID: 22244059.
      View in: PubMed
    31. Yamamoto A, Warren AP, Kim HT. Minocycline reduces articular cartilage damage following osteochondral injury. Knee. 2012 Oct; 19(5):680-3. PMID: 22297212.
      View in: PubMed
    32. Grimsrud C, Raven R, Fothergill AW, Kim HT. The in vitro elution characteristics of antifungal-loaded PMMA bone cement and calcium sulfate bone substitute. Orthopedics. 2011 Aug 08; 34(8):e378-81. PMID: 21815580.
      View in: PubMed
    33. Piper SL, Kramer JD, Kim HT, Feeley BT. Effects of local anesthetics on articular cartilage. Am J Sports Med. 2011 Oct; 39(10):2245-53. PMID: 21515808.
      View in: PubMed
    34. Laine JC, Nguyen TQ, Buckley JM, Kim HT. Effects of mixing techniques on vancomycin-impregnated polymethylmethacrylate. J Arthroplasty. 2011 Dec; 26(8):1562-6. PMID: 21474275.
      View in: PubMed
    35. Liu X, Manzano G, Kim HT, Feeley BT. A rat model of massive rotator cuff tears. J Orthop Res. 2011 Apr; 29(4):588-95. PMID: 20949443.
      View in: PubMed
    36. Liu X, Manzano G, Lovett DH, Kim HT. Role of AP-1 and RE-1 binding sites in matrix metalloproteinase-2 transcriptional regulation in skeletal muscle atrophy. Biochem Biophys Res Commun. 2010 May 28; 396(2):219-23. PMID: 20398633.
      View in: PubMed
    37. Mok JM, Durrani SK, Yamamoto A, Kim HT. Admitting service and morbidity and mortality in elderly patients after hip fracture: finding a threshold for medical versus orthopedic admission. Am J Orthop (Belle Mead NJ). 2010 Feb; 39(2):80-7. PMID: 20396681.
      View in: PubMed
    38. Liu X, Lee DJ, Skittone LK, Natsuhara K, Kim HT. Role of gelatinases in disuse-induced skeletal muscle atrophy. Muscle Nerve. 2010 Feb; 41(2):174-8. PMID: 19790245.
      View in: PubMed
    39. Dang AC, Kim HT. Chondrocyte apoptosis after simulated intraarticular fracture: a comparison of histologic detection methods. Clin Orthop Relat Res. 2009 Jul; 467(7):1877-84. PMID: 19363641; PMCID: PMC2690763.
      View in: PubMed, PubMed Central
    40. Dang AB, Tay BK, Kim HT, Nauth A, Alfonso-Jaume MA, Lovett DH. Inhibition of MMP2/MMP9 after spinal cord trauma reduces apoptosis. Spine (Phila Pa 1976). 2008 Aug 01; 33(17):E576-9. PMID: 18670324.
      View in: PubMed
    41. Teng MS, Yuen AS, Kim HT. Enhancing osteochondral allograft viability: effects of storage media composition. Clin Orthop Relat Res. 2008 Aug; 466(8):1804-9. PMID: 18506560; PMCID: PMC2584242.
      View in: PubMed, PubMed Central
    42. Kim HT, Teng MS, Dang AC. Chondrocyte apoptosis: implications for osteochondral allograft transplantation. Clin Orthop Relat Res. 2008 Aug; 466(8):1819-25. PMID: 18506558; PMCID: PMC2584268.
      View in: PubMed, PubMed Central
    43. Piper SL, Kim HT. Comparison of ropivacaine and bupivacaine toxicity in human articular chondrocytes. J Bone Joint Surg Am. 2008 May; 90(5):986-91. PMID: 18451389.
      View in: PubMed
    44. Skittone LK, Liu X, Tseng A, Kim HT. Matrix metalloproteinase-2 expression and promoter/enhancer activity in skeletal muscle atrophy. J Orthop Res. 2008 Mar; 26(3):357-63. PMID: 17960656.
      View in: PubMed
    45. Abeyta PN, Namba RS, Janku GV, Murray WR, Kim HT. Reconstruction of major segmental acetabular defects with an oblong-shaped cementless prosthesis: a long-term outcomes study. J Arthroplasty. 2008 Feb; 23(2):247-53. PMID: 18280420.
      View in: PubMed
    46. Costouros JG, Kim HT. Preventing chondrocyte programmed cell death caused by iatrogenic injury. Knee. 2007 Mar; 14(2):107-11. PMID: 17174553.
      View in: PubMed
    47. Kim HT, Zaffagnini S, Mizuno S, Abelow S, Safran MR. A peek into the possible future of management of articular cartilage injuries: gene therapy and scaffolds for cartilage repair. J Orthop Sports Phys Ther. 2006 Oct; 36(10):765-73. PMID: 17063838.
      View in: PubMed
    48. Lo MY, Kim HT. Chondrocyte apoptosis induced by hydrogen peroxide requires caspase activation but not mitochondrial pore transition. J Orthop Res. 2004 Sep; 22(5):1120-5. PMID: 15304288.
      View in: PubMed
    49. Costouros JG, Dang AC, Kim HT. Comparison of chondrocyte apoptosis in vivo and in vitro following acute osteochondral injury. J Orthop Res. 2004 May; 22(3):678-83. PMID: 15099652.
      View in: PubMed
    50. Lo MY, Kim HT. Chondrocyte apoptosis induced by collagen degradation: inhibition by caspase inhibitors and IGF-1. J Orthop Res. 2004 Jan; 22(1):140-4. PMID: 14656672.
      View in: PubMed
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