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Hilde Schjerven, PhD

TitleAssistant Professor
SchoolUCSF School of Medicine
DepartmentLaboratory Medicine
Phone415-502-3553
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    Member, UCSF Helen Diller Family Comprehensive Cancer Center (Hematopoietic Malignancies Program)

    Member, UCSF Precision Medicine in Rheumatology (PREMIER) Center


    Collapse Research 
    Collapse Research Activities and Funding
    Mechanism of Ikaros Tumor Suppression in progenitor B cell leukemia
    NIH R21CA209229Jul 9, 2016 - Jun 30, 2018
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Li S, Heller JJ, Bostick JW, Lee A, Schjerven H, Kastner P, Chan S, Chen ZE, Zhou L. Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway. Immunity. 2016 Jul 19; 45(1):185-97. PMID: 27438771.
      View in: PubMed
    2. Arenzana TL, Schjerven H, Smale ST. Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor. Genes Dev. 2015 Sep 1; 29(17):1801-16. PMID: 26314708; PMCID: PMC4573854 [Available on 03/01/16].
    3. Song C, Gowda C, Pan X, Ding Y, Tong Y, Tan BH, Wang H, Muthusami S, Ge Z, Sachdev M, Amin SG, Desai D, Gowda K, Gowda R, Robertson GP, Schjerven H, Muschen M, Payne KJ, Dovat S. Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia. Blood. 2015 Oct 8; 126(15):1813-22. PMID: 26219304; PMCID: PMC4600018.
    4. Buchner M, Park E, Geng H, Klemm L, Flach J, Passegué E, Schjerven H, Melnick A, Paietta E, Kopanja D, Raychaudhuri P, Müschen M. Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia. Nat Commun. 2015; 6:6471. PMID: 25753524; PMCID: PMC4366523.
    5. Heller JJ, Schjerven H, Li S, Lee A, Qiu J, Chen ZM, Smale ST, Zhou L. Restriction of IL-22-producing T cell responses and differential regulation of regulatory T cell compartments by zinc finger transcription factor Ikaros. J Immunol. 2014 Oct 15; 193(8):3934-46. PMID: 25194055; PMCID: PMC4185244.
    6. Schjerven H, McLaughlin J, Arenzana TL, Frietze S, Cheng D, Wadsworth SE, Lawson GW, Bensinger SJ, Farnham PJ, Witte ON, Smale ST. Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros. Nat Immunol. 2013 Oct; 14(10):1073-83. PMID: 24013668; PMCID: PMC3800053.
    7. Reynaud D, Demarco IA, Reddy KL, Schjerven H, Bertolino E, Chen Z, Smale ST, Winandy S, Singh H. Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros. Nat Immunol. 2008 Aug; 9(8):927-36. PMID: 18568028; PMCID: PMC2699484.
    8. Schneeman TA, Bruno ME, Schjerven H, Johansen FE, Chady L, Kaetzel CS. Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses. J Immunol. 2005 Jul 1; 175(1):376-84. PMID: 15972671.
      View in: PubMed
    9. Schjerven H, Tran TN, Brandtzaeg P, Johansen FE. De novo synthesized RelB mediates TNF-induced up-regulation of the human polymeric Ig receptor. J Immunol. 2004 Aug 1; 173(3):1849-57. PMID: 15265917.
      View in: PubMed
    10. Mørk G, Schjerven H, Mangschau L, Søyland E, Brandtzaeg P. Proinflammatory cytokines upregulate expression of calprotectin (L1 protein, MRP-8/MRP-14) in cultured human keratinocytes. Br J Dermatol. 2003 Sep; 149(3):484-91. PMID: 14510979.
      View in: PubMed
    11. Schjerven H, Brandtzaeg P, Johansen FE. Hepatocyte NF-1 and STAT6 cooperate with additional DNA-binding factors to activate transcription of the human polymeric Ig receptor gene in response to IL-4. J Immunol. 2003 Jun 15; 170(12):6048-56. PMID: 12794133.
      View in: PubMed
    12. Schjerven H, Brandtzaeg P, Johansen FE. A novel NF-kappa B/Rel site in intron 1 cooperates with proximal promoter elements to mediate TNF-alpha-induced transcription of the human polymeric Ig receptor. J Immunol. 2001 Dec 1; 167(11):6412-20. PMID: 11714807.
      View in: PubMed
    13. Schjerven H, Brandtzaeg P, Johansen FE. Mechanism of IL-4-mediated up-regulation of the polymeric Ig receptor: role of STAT6 in cell type-specific delayed transcriptional response. J Immunol. 2000 Oct 1; 165(7):3898-906. PMID: 11034397.
      View in: PubMed
    14. Ertesvåg H, Høidal HK, Schjerven H, Svanem BI, Valla S. Mannuronan C-5-epimerases and their application for in vitro and in vivo design of new alginates useful in biotechnology. Metab Eng. 1999 Jul; 1(3):262-9. PMID: 10937941.
      View in: PubMed
    15. Norderhaug IN, Johansen FE, Schjerven H, Brandtzaeg P. Regulation of the formation and external transport of secretory immunoglobulins. Crit Rev Immunol. 1999; 19(5-6):481-508. PMID: 10647747.
      View in: PubMed
    16. van Ginkel PR, Hsiao KM, Schjerven H, Farnham PJ. E2F-mediated growth regulation requires transcription factor cooperation. J Biol Chem. 1997 Jul 18; 272(29):18367-74. PMID: 9218478.
      View in: PubMed
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