Michael Waterfield, MD, PhD
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| Title(s) | Assistant Professor, Pediatrics |
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| School | School of Medicine |
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| Address | 550 16th. Street, #4234
San Francisco CA 94158
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| Phone | 415-353-7337 |
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| vCard | Download vCard |
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Biography
| Penn State College of Medicine, Hershey, PA | MD/PhD | 06/2005 | Medicine |
| University of California, San Francisco | Residency | 06/2008 | Pediatrics |
| University of California, San Francisco | Fellowship | 06/2011 | Pediatric Rheumatology |
Overview
Autoimmune disease affects up to 5% of the population and can cause significant morbidity and mortality. Our labs main focus is to understand the basic mechanisms by which immune tolerance is broken in order to identify novel therapeutic targets for the treatment of autoimmune diseases. We utilize a variety of mouse models to study both central tolerance and peripheral tolerance. Central tolerance is the process by which autoreactive T cells are deleted in the thymus through negative selection. We are currently utilizing a variety of novel conditional knockout mice to study the roles of specific proteins in thymic tolerance.
A second area of active research in the lab is the role of effector T cells in autoimmune disease. One subtype of CD4+ effector T cell, termed T helper 17 (Th17) cells have been found to be important in the pathogenesis of multiple autoimmune diseases and Th17 cells have been targeted therapeutically for treatment. We have identified the activating transcription factor 7 interacting protein (ATF7ip) as a novel regulator of Th17 cell differentiation and are currently studying its mechanism of action in Th17 cells and other immune cells.
Research
Bibliographic
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ATF7ip Targets Transposable Elements for H3K9me3 Deposition to Modify CD8+ T Cell Effector and Memory Responses. J Immunol. 2022 03 01; 208(5):1155-1169.
Sin JH, Kashyap S, Acenas D, Cortez JT, Lee J, Marson A, Matloubian M, Waterfield MR. PMID: 35110421; PMCID: PMC8881383.
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1 Fields:
Translation:
HumansAnimalsCells
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Gene Expression Meta-Analysis Reveals Concordance in Gene Activation, Pathway, and Cell-Type Enrichment in Dermatomyositis Target Tissues. ACR Open Rheumatol. 2019 Dec; 1(10):657-666.
Neely J, Rychkov D, Paranjpe M, Waterfield M, Kim S, Sirota M. PMID: 31872188; PMCID: PMC6917332.
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11
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The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses. J Exp Med. 2019 09 02; 216(9):2024-2037.
Sin JH, Zuckerman C, Cortez JT, Eckalbar WL, Erle DJ, Anderson MS, Waterfield MR. PMID: 31217192; PMCID: PMC6719416.
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5 Fields:
Translation:
AnimalsCells
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Analysis of pulmonary features and treatment approaches in the COPA syndrome. ERJ Open Res. 2018 Apr; 4(2).
Tsui JL, Estrada OA, Deng Z, Wang KM, Law CS, Elicker BM, Jones KD, Dell SD, Gudmundsson G, Hansdottir S, Helfgott SM, Volpi S, Gattorno M, Waterfield MR, Chan AY, Chung SA, Ley B, Shum AK. PMID: 29977900; PMCID: PMC6019741.
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26
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007 GILT-mediated antigen processing in thymic epithelial cells diminishes T cell-mediated protection from melanoma through promoting thymic deletion and regulatory T cells. Journal of Investigative Dermatology. 2016 May 1; 136(5):s2.
Rausch RM, Metzger MT, Waterfield WM, Cortez CJ, Anderson AM, Hastings HK. .
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Identification of a novel cis-regulatory element essential for immune tolerance. J Exp Med. 2015 Nov 16; 212(12):1993-2002.
LaFlam TN, Seumois G, Miller CN, Lwin W, Fasano KJ, Waterfield M, Proekt I, Vijayanand P, Anderson MS. PMID: 26527800; PMCID: PMC4647269.
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23 Fields:
Translation:
HumansAnimalsCells
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GILT-mediated processing of a self and melanoma antigen in thymic epithelial cells promotes deletion and regulatory T cells (APP3P.113). The Journal of Immunology. 2015 May 1; 194(1_Supplement):113.14-113.14.
Rausch RM, Metzger MT, Waterfield WM, Cortez CJ, Anderson AM, Hastings HK. .
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COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis. Nat Genet. 2015 Jun; 47(6):654-60.
Watkin LB, Jessen B, Wiszniewski W, Vece TJ, Jan M, Sha Y, Thamsen M, Santos-Cortez RL, Lee K, Gambin T, Forbes LR, Law CS, Stray-Pedersen A, Cheng MH, Mace EM, Anderson MS, Liu D, Tang LF, Nicholas SK, Nahmod K, Makedonas G, Canter DL, Kwok PY, Hicks J, Jones KD, Penney S, Jhangiani SN, Rosenblum MD, Dell SD, Waterfield MR, Papa FR, Muzny DM, Zaitlen N, Leal SM, Gonzaga-Jauregui C, Baylor-Hopkins Center for Mendelian Genomics, Boerwinkle E, Eissa NT, Gibbs RA, Lupski JR, Orange JS, Shum AK. PMID: 25894502; PMCID: PMC4513663.
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PubMed Mentions:
131 Fields:
Translation:
HumansCells
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Erratum: Corrigendum: The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance. Nature Immunology. 2014 Sep 1; 15(9):894-894.
Waterfield WM, Khan KI, Cortez CJ, Fan FU, Metzger MT, Greer GA, Fasano FK, Martinez-Llordella MM, Pollack PJ, Erle ED, Su SM, Anderson AM. .
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The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance. Nat Immunol. 2014 Mar; 15(3):258-65.
Waterfield M, Khan IS, Cortez JT, Fan U, Metzger T, Greer A, Fasano K, Martinez-Llordella M, Pollack JL, Erle DJ, Su M, Anderson MS. PMID: 24464130; PMCID: PMC4172453.
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PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
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Autoimmunity's collateral damage: Immunodeficiency hints at autoreactivity to cytokines. Nat Med. 2011 Sep 07; 17(9):1054-5.
Waterfield M, Anderson MS. PMID: 21900922.
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1 Fields:
Translation:
Animals
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Clues to immune tolerance: the monogenic autoimmune syndromes. Ann N Y Acad Sci. 2010 Dec; 1214:138-55.
Waterfield M, Anderson MS. PMID: 20969580; PMCID: PMC3010261.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase. Mol Cell. 2003 Mar; 11(3):685-94.
Waterfield MR, Zhang M, Norman LP, Sun SC. PMID: 12667451.
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PubMed Mentions:
98 Fields:
Translation:
HumansAnimalsCells
This graph shows the total number of publications by year. To see the data as text,
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| Year | Publications |
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| 2003 | 1 |
| 2010 | 1 |
| 2011 | 1 |
| 2014 | 2 |
| 2015 | 3 |
| 2016 | 1 |
| 2018 | 1 |
| 2019 | 2 |
| 2022 | 1 |
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