John Metcalfe, MD, PhD, MPH
|School||UCSF School of Medicine|
|Address||1001 Potrero Ave, SFGH 5|
San Francisco CA 94110
|Humboldt State University||BS|
|Tufts University ||MD, MPH|
|University of California, San Francisco||Residency ||Internal Medicine|
|University of California, San Francisco||Fellowship||Pulmonary and Critical Care Medicine|
|University of California, Berkely||PhD||Epidemiology|
I am an Assistant Professor in the Division of Pulmonary and Critical Care Medicine and the Curry International Tuberculosis Center, both at the University of California, San Francisco. My research interests focus on the diagnosis, management, and transmission of drug resistant tuberculosis, domestically and in high HIV-burden settings. I have specialized training in clinical research methods, statistical prediction, repeated measures, and causal inference through a Ph.D. obtained within the Division of Epidemiology at UC Berkeley. Internationally, I have worked as a technical consultant to the Pan American Health Organization (PAHO), Program for Appropriate Technology in Health (PATH), and USAID in national TB program evaluation, programmatic guidelines, and multidrug resistant tuberculosis operational plan development, including in Zimbabwe. Since 2011, I have enrolled over 500 individuals at risk for drug-resistant TB (K23 AI094251, Transmission and Pathogenesis of MDR-TB (Trap MDR-TB)) in Harare, Zimbabwe. In Harare, we were fortunate to produce the first population-based estimate of MDR-TB since 1995, improve time to diagnosis for patients with MDR-TB from over one year to nine days, validate low-cost diagnostic platforms for local use, and characterize the morbidity associated with cured tuberculosis in a high HIV burden setting. Additionally, we seek to support the University of Zimbabwe College of Health Sciences (UZCHS) in order to replenish its ranks of high-quality junior faculty to conduct high quality, innovative, and locally relevant TB and HIV/AIDS research, and currently support 7 doctoral candidates at this institution (D43 TW009539). More recently, in collaboration with Monica Gandhi (UCSF Division of Infectious Diseases), we have begun to focus on development of non-invasive pharmacokinetic measures to enhance MDR-TB drug development and clinical trials in South Africa (R01 AI123024). I currently hold an appointment as Lecturer within the University of Zimbabwe, and am also an investigator with the NIH Division of AIDS Tuberculosis Transformative Science Group (TB TSG), specializing in multidrug resistant TB.
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