John Metcalfe, MD, PhD, MPH
|School||UCSF School of Medicine|
|Address||1001 Potrero Ave, SFGH 5|
San Francisco CA 94110
|Humboldt State University||BS|
|Tufts University ||MD, MPH|
|University of California, San Francisco||Residency ||Internal Medicine|
|University of California, San Francisco||Fellowship||Pulmonary and Critical Care Medicine|
|University of California, Berkely||PhD||Epidemiology|
My academic interests focus on the epidemiology, diagnosis, and management of multidrug resistant tuberculosis (MDR TB), domestically and in high HIV-burden settings. My current work seeks to advance knowledge of the interactions between emergence of M. tuberculosis resistance and host drug exposure through translational research. Existing predictors of treatment response, in particular with respect to MDR TB, are inadequate, as recently demonstrated by the failure of multiple Phase III tuberculosis treatment shortening trials. Development of novel biomarkers with strong mechanistic underpinnings have the potential to transform our field through improved clinical trial end points.
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