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    John Metcalfe, MD, PhD, MPH

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address1001 Potrero Ave, SFGH 5
    San Francisco CA 94110
    Phone415-596-9348
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      Collapse Biography 
      Collapse Education and Training
      University of California, BerkelyPh.D.Division of Epidemiology2012
      University of California, San FranciscoFellowshipPulmonary and Critical Care Medicine2009
      University of California, San FranciscoResidency Medicine2006
      Tufts University School of MedicineM.D.School of Medicine2003
      Tufts University School of MedicineMPHGlobal Health2003
      Humboldt State UniversityBSMolecular Biology1998
      Michigan State UniversityABSociology1995
      Collapse Awards and Honors
      University of California, Berkeley2008Chancellor's Fellow
      Robert Wood Johnson Foundation2010Harold Amos Scholar
      Doris Duke Charitable Foundation2015Clinical Scientist Development Award

      Collapse Overview 
      Collapse Overview
      John Z. Metcalfe, MD, PhD, MPH is an Assistant Professor in the Division of Pulmonary and Critical Care Medicine. A consultant in pulmonary medicine and an intensivist at San Francisco General Hospital, Dr. Metcalfe has expertise in critical care and respiratory infectious diseases with a particular interest in clinical management of multidrug resistant tuberculosis (MDR-TB) in high HIV burden settings in Southern Africa. He also has expertise in development of non-invasive pharmacokinetic measures to enhance MDR-TB drug development and clinical trials. He is a member of the AIDS Clinical Trials Group TB Transformative Science Group, and has specialized training in epidemiology, statistical prediction, and diagnostic test evaluation. He is the specialty editor for respiratory diseases at PLoS Medicine.


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      Collapse Global Health

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. O'Donnell MR, Daftary A, Frick M, Hirsch-Moverman Y, Amico KR, Senthilingam M, Wolf A, Metcalfe JZ, Isaakidis P, Davis JL, Zelnick JR, Brust JC, Naidu N, Garretson M, Bangsberg DR, Padayatchi N, Friedland G. Re-inventing adherence: toward a patient-centered model of care for drug-resistant tuberculosis and HIV. Int J Tuberc Lung Dis. 2016 Apr; 20(4):430-4. PMID: 26970149.
        View in: PubMed
      2. Metcalfe JZ, O'Donnell MR, Bangsberg DR. Moving Beyond Directly Observed Therapy for Tuberculosis. PLoS Med. 2015 Sep; 12(9):e1001877. PMID: 26372602.
        View in: PubMed
      3. Metcalfe JZ, Makumbirofa S, Makamure B, Mutetwa R, Peñaloza RA, Sandy C, Bara W, Mungofa S, Hopewell PC, Mason P. Suboptimal specificity of Xpert MTB/RIF among treatment-experienced patients. Eur Respir J. 2015 May; 45(5):1504-6. PMID: 25792637.
        View in: PubMed
      4. Coscolla M, Barry PM, Oeltmann JE, Koshinsky H, Shaw T, Cilnis M, Posey J, Rose J, Weber T, Fofanov VY, Gagneux S, Kato-Maeda M, Metcalfe JZ. Genomic Epidemiology of Multidrug-Resistant Mycobacterium tuberculosis During Transcontinental Spread. J Infect Dis. 2015 Jul 15; 212(2):302-10. PMID: 25601940.
        View in: PubMed
      5. Metcalfe JZ, Vittinghoff E, Hopewell PC. Analysis of Green Light Committee Implementation and Acquisition of Second-line Drug Resistance. Clin Infect Dis. 2015 Mar 15; 60(6):970. PMID: 25527651.
        View in: PubMed
      6. Kelly JD, Grace Lin SY, Barry PM, Keh C, Higashi J, Metcalfe JZ. Xpert MTB/RIF False Detection of Rifampin-Resistant Tuberculosis from Prior Infection. Am J Respir Crit Care Med. 2014 Dec 1; 190(11):1316-8. PMID: 25436783.
        View in: PubMed
      7. Metcalfe JZ, Mason P, Mungofa S, Sandy C, Hopewell PC. Empiric tuberculosis treatment in retreatment patients in high HIV/tuberculosis-burden settings. Lancet Infect Dis. 2014 Sep; 14(9):794-5. PMID: 25164190.
        View in: PubMed
      8. Mupfumi L, Makamure B, Chirehwa M, Sagonda T, Zinyowera S, Mason P, Metcalfe JZ, Mutetwa R. Impact of Xpert MTB/RIF on Antiretroviral Therapy-Associated Tuberculosis and Mortality: A Pragmatic Randomized Controlled Trial. Open Forum Infect Dis. 2014 Mar; 1(1):ofu038. PMID: 25734106.
        View in: PubMed
      9. Davis JL, Kawamura LM, Chaisson LH, Grinsdale J, Benhammou J, Ho C, Babst A, Banouvong H, Metcalfe JZ, Pandori M, Hopewell PC, Cattamanchi A. Impact of GeneXpert MTB/RIF on patients and tuberculosis programs in a low-burden setting. a hypothetical trial. Am J Respir Crit Care Med. 2014 Jun 15; 189(12):1551-9. PMID: 24869625; PMCID: PMC4226012 [Available on 06/15/15].
      10. Metcalfe JZ, Makumbirofa S, Makamure B, Sandy C, Bara W, Mungofa S, Hopewell PC, Mason P. Drug-resistant tuberculosis in high-risk groups, Zimbabwe. Emerg Infect Dis. 2014 Jan; 20(1):135-7. PMID: 24377879; PMCID: PMC3884722.
      11. Pai M, Denkinger CM, Kik SV, Rangaka MX, Zwerling A, Oxlade O, Metcalfe JZ, Cattamanchi A, Dowdy DW, Dheda K, Banaei N. Gamma interferon release assays for detection of Mycobacterium tuberculosis infection. Clin Microbiol Rev. 2014 Jan; 27(1):3-20. PMID: 24396134; PMCID: PMC3910908 [Available on 01/01/15].
      12. Millman AJ, Dowdy DW, Miller CR, Brownell R, Metcalfe JZ, Cattamanchi A, Davis JL. Rapid molecular testing for TB to guide respiratory isolation in the U.S.: a cost-benefit analysis. PLoS One. 2013; 8(11):e79669. PMID: 24278155; PMCID: PMC3835836.
      13. Prach LM, Pascopella L, Barry PM, Flood J, Porco TC, Hopewell PC, Metcalfe JZ. Rifampin monoresistant tuberculosis and HIV comorbidity in California, 1993-2008: a retrospective cohort study. AIDS. 2013 Oct 23; 27(16):2615-22. PMID: 23842135.
        View in: PubMed
      14. Cattamanchi A, Walter ND, Metcalfe JZ, Davis JL. A transcriptional signature for active TB: have we found the needle in the haystack? PLoS Med. 2013 Oct; 10(10):e1001539. PMID: 24167454; PMCID: PMC3805486.
      15. Gopal M, Padayatchi N, Metcalfe JZ, O'Donnell MR. Systematic review of clofazimine for the treatment of drug-resistant tuberculosis. Int J Tuberc Lung Dis. 2013 Aug; 17(8):1001-7. PMID: 23541151; PMCID: PMC4003893.
      16. Metcalfe JZ, Porco TC, Westenhouse J, Damesyn M, Facer M, Hill J, Xia Q, Watt JP, Hopewell PC, Flood J. Tuberculosis and HIV co-infection, California, USA, 1993–2008. Emerg Infect Dis. 2013 Mar; 19(3):400-6. PMID: 23745218.
        View in: PubMed
      17. Makamure B, Mhaka J, Makumbirofa S, Mutetwa R, Mupfumi L, Mason P, Metcalfe JZ. Microscopic-observation drug-susceptibility assay for the diagnosis of drug-resistant tuberculosis in Harare, Zimbabwe. PLoS One. 2013; 8(2):e55872. PMID: 23409072; PMCID: PMC3569460.
      18. Metcalfe JZ, Cattamanchi A, McCulloch CE, Lew JD, Ha NP, Graviss EA. Test variability of the QuantiFERON-TB gold in-tube assay in clinical practice. Am J Respir Crit Care Med. 2013 Jan 15; 187(2):206-11. PMID: 23103734; PMCID: PMC3570654.
      19. Dantes R, Metcalfe J, Kim E, Kato-Maeda M, Hopewell PC, Kawamura M, Nahid P, Cattamanchi A. Impact of isoniazid resistance-conferring mutations on the clinical presentation of isoniazid monoresistant tuberculosis. PLoS One. 2012; 7(5):e37956. PMID: 22649569; PMCID: PMC3359338.
      20. Geng EH, Glidden DV, Bangsberg DR, Bwana MB, Musinguzi N, Nash D, Metcalfe JZ, Yiannoutsos CT, Martin JN, Petersen ML. A causal framework for understanding the effect of losses to follow-up on epidemiologic analyses in clinic-based cohorts: the case of HIV-infected patients on antiretroviral therapy in Africa. Am J Epidemiol. 2012 May 15; 175(10):1080-7. PMID: 22306557; PMCID: PMC3353135.
      21. Metcalfe JZ, Everett CK, Steingart KR, Cattamanchi A, Huang L, Hopewell PC, Pai M. Interferon-? release assays for active pulmonary tuberculosis diagnosis in adults in low- and middle-income countries: systematic review and meta-analysis. J Infect Dis. 2011 Nov 15; 204 Suppl 4:S1120-9. PMID: 21996694; PMCID: PMC3192542.
      22. Brust JC, O'Donnell MR, Metcalfe JZ. TB/HIV: an orphan disease? Am J Respir Crit Care Med. 2011 Jun 1; 183(11):1441-2. PMID: 21642250.
        View in: PubMed
      23. Cattamanchi A, Smith R, Steingart KR, Metcalfe JZ, Date A, Coleman C, Marston BJ, Huang L, Hopewell PC, Pai M. Interferon-gamma release assays for the diagnosis of latent tuberculosis infection in HIV-infected individuals: a systematic review and meta-analysis. J Acquir Immune Defic Syndr. 2011 Mar 1; 56(3):230-8. PMID: 21239993; PMCID: PMC3383328.
      24. Kato-Maeda M, Metcalfe JZ, Flores L. Genotyping of Mycobacterium tuberculosis: application in epidemiologic studies. Future Microbiol. 2011 Feb; 6(2):203-16. PMID: 21366420.
        View in: PubMed
      25. Metcalfe JZ, Kim EY, Lin SY, Cattamanchi A, Oh P, Flood J, Hopewell PC, Kato-Maeda M. Determinants of multidrug-resistant tuberculosis clusters, California, USA, 2004-2007. Emerg Infect Dis. 2010 Sep; 16(9):1403-9. PMID: 20735924; PMCID: PMC3294976.
      26. Davis JL, Worodria W, Kisembo H, Metcalfe JZ, Cattamanchi A, Kawooya M, Kyeyune R, den Boon S, Powell K, Okello R, Yoo S, Huang L. Clinical and radiographic factors do not accurately diagnose smear-negative tuberculosis in HIV-infected inpatients in Uganda: a cross-sectional study. PLoS One. 2010; 5(3):e9859. PMID: 20361038; PMCID: PMC2845634.
      27. Metcalfe JZ, Cattamanchi A, Vittinghoff E, Ho C, Grinsdale J, Hopewell PC, Kawamura LM, Nahid P. Evaluation of quantitative IFN-gamma response for risk stratification of active tuberculosis suspects. Am J Respir Crit Care Med. 2010 Jan 1; 181(1):87-93. PMID: 19797760; PMCID: PMC2797629.
      28. Cattamanchi A, Dantes RB, Metcalfe JZ, Jarlsberg LG, Grinsdale J, Kawamura LM, Osmond D, Hopewell PC, Nahid P. Clinical characteristics and treatment outcomes of patients with isoniazid-monoresistant tuberculosis. Clin Infect Dis. 2009 Jan 15; 48(2):179-85. PMID: 19086909; PMCID: PMC2756509.
      29. Gouveia EL, Metcalfe J, de Carvalho AL, Aires TS, Villasboas-Bisneto JC, Queirroz A, Santos AC, Salgado K, Reis MG, Ko AI. Leptospirosis-associated severe pulmonary hemorrhagic syndrome, Salvador, Brazil. Emerg Infect Dis. 2008 Mar; 14(3):505-8. PMID: 18325275; PMCID: PMC2570821.
      30. Roshanravan B, Kari E, Gilman RH, Cabrera L, Lee E, Metcalfe J, Calderon M, Lescano AG, Montenegro SH, Calampa C, Vinetz JM. Endemic malaria in the Peruvian Amazon region of Iquitos. Am J Trop Med Hyg. 2003 Jul; 69(1):45-52. PMID: 12932096.
        View in: PubMed
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