Markus Muschen, MD, PhD

Title(s)Professor, Laboratory Medicine
SchoolSchool of Medicine
AddressLocation Required, #001
Varies CA 00000
Phone415-502-0388
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    Collapse Biography 
    Collapse Education and Training
    Institute of Genetics, University of Cologne, Cologne, GermanyMD-PhD2003Department of Immunology
    University Medical Center Cologne, Cologne, GermanyClinical training2001Department of Haematology-Oncology
    University Medical Center Düsseldorf, GermanyPhysician-in-training2000Department of Medicine
    University of Dusseldorf, GermanyM.D.2000University Medical Center Düsseldorf
    University of Paris V, René Descartes, FranceMedical student1997Institut Pasteur
    University of Nantes, Nantes, FranceMedical student1995INSERM Unité 437, Transplantation Immunology
    Collapse Awards and Honors
    Howard Hughes Medical Institute2016HHMI Faculty Scholar Award
    National Cancer Institute2016NCI Outstanding Investigator Award
    Wellcome Trust2013Wellcome Trust Senior Investigator Award
    The Institute of Cancer Research, London, UK2012Haddow Professorship
    Leukemia and Lymphoma Society2010Scholar Award
    German Association of Hematology and Oncology2006Leukemia Research Award
    German Association for Immunology2004Fritz-Melchers Award
    University of Cologne2003Habilitation Thesis Award
    State of North-Rhine Westphalia2002Stem Cell Research Award
    German Science Foundation (DFG)2001Emmy-Noether Young Investigator Award
    Heinrich-Heine-Universitat Dusseldorf1999Doctoral Thesis Award

    Collapse Overview 
    Collapse Overview
    ACTIVE RESEARCH SUPPORT

    R01CA137060-A1 Müschen (PI) 04/01/2008 - 12/31/2012
    NCI/NIH
    “Pre-B cell receptor signaling in acute lymphoblastic leukemia”. The central goal of this project is to clarify the role of pre-B cell receptor signaling in acute lymphoblastic leukemia.

    R01CA139032 Müschen (PI) 04/01/2008 - 12/31/2012
    NCI/NIH
    “AID-mediated genetic instability in BCR-ABL1-transformed B cell lineage leukemia”. The central goal is (1) to identify the regulatory mechanisms that lead to aberrant expression of AID and (2) to identify the consequences of aberrant AID-activity in leukemia cells.

    1R01CA157644 Müschen (PI) 04/01/2011-03/31/2016
    NIH/NCI
    ‘Infectious origins of childhood leukemia’. The central goal of this proposal is to experimentally test the ‘delayed infections hypothesis’ in the etiology of childhood ALL and to delineate mechanisms of genetic vulnerability of human pre-B cells in the context of infection.

    R21CA152497 Müschen (PI) 06/01/2010 - 05/31/2012
    NCI/NIH
    “Mechanism of BCL6-dependent stem cell maintenance in B cell lineage leukemia”. The central goals of this proposal are (1) to clarify the role of BCL6 in leukemia-initiation of Ph+ ALL and (2) To determine the frequency and phenotype of BCL6-dependent leukemia stem cells.

    TR2-01816 Müschen (PI) 10/01/2010-09/30/2013
    California Institute for Regenerative Medicine (CIRM)
    Early Translation Award. Development of a BCL6 small molecule inhibitor for targeted eradication of leukemia stem cells. The main goals of this project are (1) computer aided drug-design of BCL6 lateral groove inhibitors, (2) PK/PD assays and SAR studies of identified lead compound series and (3) pre-clinical validation.

    AACR 138564 Müschen (PI) 12/01/2009 - 11/30/2012
    AACR Stand Up To Cancer Innovation Award
    Stand Up To Cancer Innovation Award: Role of BCL6 in leukemia stem cell self-renewal. The main goal of this project is to study the role of BCL6 in the maintenance of leukemia-initiating cells in ALL.

    LLS 1497-11 Müschen (PI) 10/01/2010-09/30/2015
    The Leukemia and Lymphoma Society Scholar Award
    Leukemia and Lymphoma Society Scholar Award, will cover salary expenses related to NIH grant R01CA137060 ‘Pre-B cell receptor signaling in acute lymphoblastic leukemia’.

    LLS 6132-09 Müschen (PI) 10/01/2008-09/30/2012
    The Leukemia and Lymphoma Society
    Translational Research Grant ‘Targeting AID in BCR-ABL1-driven leukemia’. The main goal of this project is to study the role of AID in aberrant somatic hypermutation as a cause of genetic instability.

    LLS 6097-10 Müschen (PI) 07/01/2009-06/30/2013
    The Leukemia and Lymphoma Society
    Translational Research Grant ‘BCL6 in oncogene-induced senescence’. The main goal of this project is to study the role of BCL6 in oncogene-induced senescence in MYC-driven B cell lymphoma.

    LLS 7005-11 Müschen (Project-PI) 10/01/2010-09/30/2015
    Leukemia and Lymphoma Society SCOR
    Project 2: Dual targeting of tyrosine kinase and feedback signaling in leukemia. Goals are identification of novel oncogenic tyrosine kinases and characterization of feedback mechanisms in response to tyrosine kinase inhibition. Brian J Druker, Portland, OR is the PI of the SCOR.

    LLS 7005-11 Müschen (Project-PI) 10/01/2010-09/30/2015
    Leukemia and Lymphoma Society SCOR
    Core E: (1) Generate and make xenografted samples available to SCOR projects, (2) Generate a centralized multidimensional database which links flow cytometry data, cytogenetics, gene expression, SNP chip analysis and clinical information. Brian J Druker, Portland, OR is the PI of the SCOR.

    Collapse Research 
    Collapse Research Activities and Funding
    Targeting oncogenic TCR signaling in PTCL
    NIH/NCI P01CA233412Sep 1, 2019 - Aug 31, 2024
    Role: Principal Investigator
    CD25-mediated feedback control of BCR-signaling and its oncogenic mimics
    NIH R01CA213138Jun 1, 2017 - May 31, 2023
    Role: Principal Investigator
    Metabolic gatekeepers in B-cell malignancies
    NIH R35CA197628Apr 1, 2016 - Aug 31, 2028
    Role: Principal Investigator
    Negative feedback signaling in tyrosine kinase-driven leukemia
    NIH R01CA172558Jul 1, 2013 - Apr 30, 2018
    Role: Principal Investigator
    Targeting BCL6 in tyrosine kinase-driven leukemia
    NIH R01CA169458May 15, 2013 - Apr 30, 2018
    Role: Principal Investigator
    Targeted activation of autoimmune checkpoints in B cell malignancies
    NIH R01CA157644Jun 1, 2011 - Dec 31, 2021
    Role: Principal Investigator
    Mechanism of BCL6-dependent stem cell maintenance in B cell lineage leukemia
    NIH R21CA152497Jul 1, 2010 - Jun 30, 2012
    Role: Principal Investigator
    AID-mediated genetic instability in BCR-ABL1-transformed B cell lineage leukemia
    NIH R01CA139032Mar 18, 2009 - Jan 31, 2015
    Role: Principal Investigator
    PRE-B CELL RECEPTOR SIGNALING IN ACUTE LYMPHOBLASTIC LEUKEMIA
    NIH R01CA137060Dec 1, 2008 - Jan 31, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Correction: Protein Phosphatase 2A as a Therapeutic Target in Small Cell Lung Cancer. Mol Cancer Ther. 2022 Apr 01; 21(4):700. Mirzapoiazova T, Xiao G, Mambetsariev B, Nasser MW, Miaou E, Singhal SS, Srivastava S, Mambetsariev I, Nelson MS, Nam A, Behal A, Arvanitis LD, Atri P, Muschen M, Tissot FLH, Miser J, Kovach JS, Sattler M, Batra SK, Kulkarni P, Salgia R. PMID: 35373301.
      View in: PubMed   Mentions:    Fields:    
    2. Protein Phosphatase 2A as a Therapeutic Target in Small Cell Lung Cancer. Mol Cancer Ther. 2021 10; 20(10):1820-1835. Mirzapoiazova T, Xiao G, Mambetsariev B, Nasser MW, Miaou E, Singhal SS, Srivastava S, Mambetsariev I, Nelson MS, Nam A, Behal A, Arvanitis LD, Atri P, Muschen M, Tissot FLH, Miser J, Kovach JS, Sattler M, Batra SK, Kulkarni P, Salgia R. PMID: 34253596; PMCID: PMC8722383.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    3. IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia. Blood. 2020 09 24; 136(13):1520-1534. Song C, Ge Z, Ding Y, Tan BH, Desai D, Gowda K, Amin S, Gowda R, Robertson GP, Yue F, Huang S, Spiegelman V, Payne JL, Reeves ME, Gurel Z, Iyer S, Dhanyamraju PK, Xiang M, Kawasawa YI, Cury NM, Yunes JA, McGrath M, Schramm J, Su R, Yang Y, Zhao Z, Lyu X, Muschen M, Payne KJ, Gowda C, Dovat S. PMID: 32396934; PMCID: PMC7515690.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    4. Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease. Nat Commun. 2017 10 17; 8(1):978. Deng R, Hurtz C, Song Q, Yue C, Xiao G, Yu H, Wu X, Muschen M, Forman S, Martin PJ, Zeng D. PMID: 29042531; PMCID: PMC5645449.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    5. Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells. J Clin Invest. 2017 Jun 01; 127(6):2392-2406. Nieborowska-Skorska M, Sullivan K, Dasgupta Y, Podszywalow-Bartnicka P, Hoser G, Maifrede S, Martinez E, Di Marcantonio D, Bolton-Gillespie E, Cramer-Morales K, Lee J, Li M, Slupianek A, Gritsyuk D, Cerny-Reiterer S, Seferynska I, Stoklosa T, Bullinger L, Zhao H, Gorbunova V, Piwocka K, Valent P, Civin CI, Muschen M, Dick JE, Wang JC, Bhatia S, Bhatia R, Eppert K, Minden MD, Sykes SM, Skorski T. PMID: 28481221; PMCID: PMC5451241.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    6. The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 2016 07 11; 30(1):183. Townsend EC, Murakami MA, Christodoulou A, Christie AL, Köster J, DeSouza TA, Morgan EA, Kallgren SP, Liu H, Wu SC, Plana O, Montero J, Stevenson KE, Rao P, Vadhi R, Andreeff M, Armand P, Ballen KK, Barzaghi-Rinaudo P, Cahill S, Clark RA, Cooke VG, Davids MS, DeAngelo DJ, Dorfman DM, Eaton H, Ebert BL, Etchin J, Firestone B, Fisher DC, Freedman AS, Galinsky IA, Gao H, Garcia JS, Garnache-Ottou F, Graubert TA, Gutierrez A, Halilovic E, Harris MH, Herbert ZT, Horwitz SM, Inghirami G, Intlekofer AM, Ito M, Izraeli S, Jacobsen ED, Jacobson CA, Jeay S, Jeremias I, Kelliher MA, Koch R, Konopleva M, Kopp N, Kornblau SM, Kung AL, Kupper TS, LeBoeuf NR, LaCasce AS, Lees E, Li LS, Look AT, Murakami M, Muschen M, Neuberg D, Ng SY, Odejide OO, Orkin SH, Paquette RR, Place AE, Roderick JE, Ryan JA, Sallan SE, Shoji B, Silverman LB, Soiffer RJ, Steensma DP, Stegmaier K, Stone RM, Tamburini J, Thorner AR, van Hummelen P, Wadleigh M, Wiesmann M, Weng AP, Wuerthner JU, Williams DA, Wollison BM, Lane AA, Letai A, Bertagnolli MM, Ritz J, Brown M, Long H, Aster JC, Shipp MA, Griffin JD, Weinstock DM. PMID: 27479034.
      View in: PubMed   Mentions: 37     Fields:    
    7. The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 2016 04 11; 29(4):574-586. Townsend EC, Murakami MA, Christodoulou A, Christie AL, Köster J, DeSouza TA, Morgan EA, Kallgren SP, Liu H, Wu SC, Plana O, Montero J, Stevenson KE, Rao P, Vadhi R, Andreeff M, Armand P, Ballen KK, Barzaghi-Rinaudo P, Cahill S, Clark RA, Cooke VG, Davids MS, DeAngelo DJ, Dorfman DM, Eaton H, Ebert BL, Etchin J, Firestone B, Fisher DC, Freedman AS, Galinsky IA, Gao H, Garcia JS, Garnache-Ottou F, Graubert TA, Gutierrez A, Halilovic E, Harris MH, Herbert ZT, Horwitz SM, Inghirami G, Intlekofer AM, Ito M, Izraeli S, Jacobsen ED, Jacobson CA, Jeay S, Jeremias I, Kelliher MA, Koch R, Konopleva M, Kopp N, Kornblau SM, Kung AL, Kupper TS, LeBoeuf NR, LaCasce AS, Lees E, Li LS, Look AT, Murakami M, Muschen M, Neuberg D, Ng SY, Odejide OO, Orkin SH, Paquette RR, Place AE, Roderick JE, Ryan JA, Sallan SE, Shoji B, Silverman LB, Soiffer RJ, Steensma DP, Stegmaier K, Stone RM, Tamburini J, Thorner AR, van Hummelen P, Wadleigh M, Wiesmann M, Weng AP, Wuerthner JU, Williams DA, Wollison BM, Lane AA, Letai A, Bertagnolli MM, Ritz J, Brown M, Long H, Aster JC, Shipp MA, Griffin JD, Weinstock DM. PMID: 27070704; PMCID: PMC5177991.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansAnimalsCells
    8. Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia. Oncotarget. 2016 Apr 05; 7(14):18736-49. Sun H, Lin DC, Guo X, Kharabi Masouleh B, Gery S, Cao Q, Alkan S, Ikezoe T, Akiba C, Paquette R, Chien W, Müller-Tidow C, Jing Y, Agelopoulos K, Müschen M, Koeffler HP. PMID: 26934650; PMCID: PMC4951325.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    9. PTEN opposes negative selection and enables oncogenic transformation of pre-B cells. Nat Med. 2016 Apr; 22(4):379-87. Shojaee S, Chan LN, Buchner M, Cazzaniga V, Cosgun KN, Geng H, Qiu YH, von Minden MD, Ernst T, Hochhaus A, Cazzaniga G, Melnick A, Kornblau SM, Graeber TG, Wu H, Jumaa H, Müschen M. PMID: 26974310; PMCID: PMC5178869.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    10. Normal ABL1 is a tumor suppressor and therapeutic target in human and mouse leukemias expressing oncogenic ABL1 kinases. Blood. 2016 04 28; 127(17):2131-43. Dasgupta Y, Koptyra M, Hoser G, Kantekure K, Roy D, Gornicka B, Nieborowska-Skorska M, Bolton-Gillespie E, Cerny-Reiterer S, Müschen M, Valent P, Wasik MA, Richardson C, Hantschel O, van der Kuip H, Stoklosa T, Skorski T. PMID: 26864341; PMCID: PMC4850868.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    11. Pre-BCR signaling in precursor B-cell acute lymphoblastic leukemia regulates PI3K/AKT, FOXO1 and MYC, and can be targeted by SYK inhibition. Leukemia. 2016 06; 30(6):1246-54. Köhrer S, Havranek O, Seyfried F, Hurtz C, Coffey GP, Kim E, Ten Hacken E, Jäger U, Vanura K, O'Brien S, Thomas DA, Kantarjian H, Ghosh D, Wang Z, Zhang M, Ma W, Jumaa H, Debatin KM, Müschen M, Meyer LH, Davis RE, Burger JA. PMID: 26847027; PMCID: PMC5459356.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    12. BCOR regulates myeloid cell proliferation and differentiation. Leukemia. 2016 05; 30(5):1155-65. Cao Q, Gearhart MD, Gery S, Shojaee S, Yang H, Sun H, Lin DC, Bai JW, Mead M, Zhao Z, Chen Q, Chien WW, Alkan S, Alpermann T, Haferlach T, Müschen M, Bardwell VJ, Koeffler HP. PMID: 26847029; PMCID: PMC5131645.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    13. MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199. Cell Rep. 2015 Dec 29; 13(12):2715-27. Benito JM, Godfrey L, Kojima K, Hogdal L, Wunderlich M, Geng H, Marzo I, Harutyunyan KG, Golfman L, North P, Kerry J, Ballabio E, Chonghaile TN, Gonzalo O, Qiu Y, Jeremias I, Debose L, O'Brien E, Ma H, Zhou P, Jacamo R, Park E, Coombes KR, Zhang N, Thomas DA, O'Brien S, Kantarjian HM, Leverson JD, Kornblau SM, Andreeff M, Müschen M, Zweidler-McKay PA, Mulloy JC, Letai A, Milne TA, Konopleva M. PMID: 26711339; PMCID: PMC4700051.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    14. Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia. Leukemia. 2016 06; 30(6):1436-40. Song C, Pan X, Ge Z, Gowda C, Ding Y, Li H, Li Z, Yochum G, Muschen M, Li Q, Payne KJ, Dovat S. PMID: 26639180; PMCID: PMC4889471.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    15. Infection and the Perils of B-cell Activation. Cancer Discov. 2015 Dec; 5(12):1244-6. Greaves M, Müschen M. PMID: 26637659; PMCID: PMC4758198.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    16. MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia. Blood. 2015 Nov 05; 126(19):2202-12. Jones CL, Gearheart CM, Fosmire S, Delgado-Martin C, Evensen NA, Bride K, Waanders AJ, Pais F, Wang J, Bhatla T, Bitterman DS, de Rijk SR, Bourgeois W, Dandekar S, Park E, Burleson TM, Madhusoodhan PP, Teachey DT, Raetz EA, Hermiston ML, Müschen M, Loh ML, Hunger SP, Zhang J, Garabedian MJ, Porter CC, Carroll WL. PMID: 26324703; PMCID: PMC4635116.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    17. Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia. Blood. 2015 Oct 08; 126(15):1813-22. Song C, Gowda C, Pan X, Ding Y, Tong Y, Tan BH, Wang H, Muthusami S, Ge Z, Sachdev M, Amin SG, Desai D, Gowda K, Gowda R, Robertson GP, Schjerven H, Muschen M, Payne KJ, Dovat S. PMID: 26219304; PMCID: PMC4600018.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    18. Infectious origins of childhood leukemia. Oncotarget. 2015 Jul 10; 6(19):16798-9. Swaminathan S, Müschen M. PMID: 26196452; PMCID: PMC4627260.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    19. Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia. Cancer Cell. 2015 Jul 13; 28(1):114-28. Shojaee S, Caeser R, Buchner M, Park E, Swaminathan S, Hurtz C, Geng H, Chan LN, Klemm L, Hofmann WK, Qiu YH, Zhang N, Coombes KR, Paietta E, Molkentin J, Koeffler HP, Willman CL, Hunger SP, Melnick A, Kornblau SM, Müschen M. PMID: 26073130; PMCID: PMC4565502.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    20. HSP90 inhibitors decrease AID levels and activity in mice and in human cells. Eur J Immunol. 2015 Aug; 45(8):2365-76. Montamat-Sicotte D, Litzler LC, Abreu C, Safavi S, Zahn A, Orthwein A, Müschen M, Oppezzo P, Muñoz DP, Di Noia JM. PMID: 25912253; PMCID: PMC4536124.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    21. Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia. Nat Immunol. 2015 Jul; 16(7):766-774. Swaminathan S, Klemm L, Park E, Papaemmanuil E, Ford A, Kweon SM, Trageser D, Hasselfeld B, Henke N, Mooster J, Geng H, Schwarz K, Kogan SC, Casellas R, Schatz DG, Lieber MR, Greaves MF, Müschen M. PMID: 25985233; PMCID: PMC4475638.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    22. Ph+ ALL: drawing strength from a benign past. Blood. 2015 May 07; 125(19):2879-80. Müschen M. PMID: 25953975; PMCID: PMC4424411.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    23. YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway. J Hematol Oncol. 2015 Apr 22; 8:39. Chang BH, Johnson K, LaTocha D, Rowley JS, Bryant J, Burke R, Smith RL, Loriaux M, Müschen M, Mullighan C, Druker BJ, Tyner JW. PMID: 25895498; PMCID: PMC4408565.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    24. Rationale for targeting the pre-B-cell receptor signaling pathway in acute lymphoblastic leukemia. Blood. 2015 Jun 11; 125(24):3688-93. Müschen M. PMID: 25878119; PMCID: PMC4463734.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    25. Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2015 May 21; 521(7552):357-61. Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M. PMID: 25799995; PMCID: PMC4441554.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    26. Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia. Nat Commun. 2015 Mar 10; 6:6471. Buchner M, Park E, Geng H, Klemm L, Flach J, Passegué E, Schjerven H, Melnick A, Paietta E, Kopanja D, Raychaudhuri P, Müschen M. PMID: 25753524; PMCID: PMC4366523.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    27. Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia. Cancer Cell. 2015 Mar 09; 27(3):409-25. Geng H, Hurtz C, Lenz KB, Chen Z, Baumjohann D, Thompson S, Goloviznina NA, Chen WY, Huan J, LaTocha D, Ballabio E, Xiao G, Lee JW, Deucher A, Qi Z, Park E, Huang C, Nahar R, Kweon SM, Shojaee S, Chan LN, Yu J, Kornblau SM, Bijl JJ, Ye BH, Ansel KM, Paietta E, Melnick A, Hunger SP, Kurre P, Tyner JW, Loh ML, Roeder RG, Druker BJ, Burger JA, Milne TA, Chang BH, Müschen M. PMID: 25759025; PMCID: PMC4618684.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    28. Human lymphoid translocation fragile zones are hypomethylated and have accessible chromatin. Mol Cell Biol. 2015 Apr; 35(7):1209-22. Lu Z, Lieber MR, Tsai AG, Pardo CE, Müschen M, Kladde MP, Hsieh CL. PMID: 25624348; PMCID: PMC4355534.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    29. Mechanisms of pre-B-cell receptor checkpoint control and its oncogenic subversion in acute lymphoblastic leukemia. Immunol Rev. 2015 Jan; 263(1):192-209. Buchner M, Swaminathan S, Chen Z, Müschen M. PMID: 25510278.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    30. Follicular lymphoma: too many reminders for a memory B cell. J Clin Invest. 2014 Dec; 124(12):5095-8. Swaminathan S, Müschen M. PMID: 25384212; PMCID: PMC4348960.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    31. Identification and characterization of OSTL (RNF217) encoding a RING-IBR-RING protein adjacent to a translocation breakpoint involving ETV6 in childhood ALL. Sci Rep. 2014 Oct 09; 4:6565. Fontanari Krause LM, Japp AS, Krause A, Mooster J, Chopra M, Müschen M, Bohlander SK. PMID: 25298122; PMCID: PMC4190505.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    32. Targeting the B-cell receptor signaling pathway in B lymphoid malignancies. Curr Opin Hematol. 2014 Jul; 21(4):341-9. Buchner M, Müschen M. PMID: 24811161; PMCID: PMC4136419.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    33. Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):E2219-28. Kharabi Masouleh B, Geng H, Hurtz C, Chan LN, Logan AC, Chang MS, Huang C, Swaminathan S, Sun H, Paietta E, Melnick AM, Koeffler P, Müschen M. PMID: 24821775; PMCID: PMC4040579.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    34. AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine. Oncotarget. 2014 Jan 15; 5(1):211-23. Tsai CT, Yang PM, Chern TR, Chuang SH, Lin JH, Klemm L, Müschen M, Chen CC. PMID: 24457556; PMCID: PMC3960202.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
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    38. VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia. Leukemia. 2014 Jan; 28(1):216-20. Mangum DS, Downie J, Mason CC, Jahromi MS, Joshi D, Rodic V, Müschen M, Meeker N, Trede N, Frazer JK, Zhou Y, Cheng C, Jeha S, Pui CH, Willman CL, Harvey RC, Hunger SP, Yang JJ, Barnette P, Mullighan CG, Miles RR, Schiffman JD. PMID: 23881307; PMCID: PMC4043450.
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    67. Development of resistance to dasatinib in Bcr/Abl-positive acute lymphoblastic leukemia. Leukemia. 2010 Apr; 24(4):813-20. Fei F, Stoddart S, Müschen M, Kim YM, Groffen J, Heisterkamp N. PMID: 20111071; PMCID: PMC3038787.
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    75. The WNT receptor FZD7 contributes to self-renewal signaling of human embryonic stem cells. Biol Chem. 2008 Jul; 389(7):897-903. Melchior K, Weiss J, Zaehres H, Kim YM, Lutzko C, Roosta N, Hescheler J, Müschen M. PMID: 18681827.
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      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    92. T lymphoid differentiation in human bone marrow. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6747-52. Klein F, Feldhahn N, Lee S, Wang H, Ciuffi F, von Elstermann M, Toribio ML, Sauer H, Wartenberg M, Barath VS, Krönke M, Wernet P, Rowley JD, Müschen M. PMID: 12738882; PMCID: PMC164518.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    93. Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species. FASEB J. 2003 Mar; 17(3):503-5. Wartenberg M, Ling FC, Müschen M, Klein F, Acker H, Gassmann M, Petrat K, Pütz V, Hescheler J, Sauer H. PMID: 12514119.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansCells
    94. Molecular portraits of B cell lineage commitment. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):10014-9. Müschen M, Lee S, Zhou G, Feldhahn N, Barath VS, Chen J, Moers C, Krönke M, Rowley JD, Wang SM. PMID: 12119411; PMCID: PMC126616.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    95. The origin of CD95-gene mutations in B-cell lymphoma. Trends Immunol. 2002 Feb; 23(2):75-80. Müschen M, Rajewsky K, Krönke M, Küppers R. PMID: 11929130.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    96. Resistance to CD95-mediated apoptosis in breast cancer is not due to somatic mutation of the CD95 gene. Int J Cancer. 2001 Apr 15; 92(2):309-10. Müschen M, Re D, Betz B, Moers C, Wolf J, Niederacher D, Diehl V, Beckmann MW. PMID: 11291062.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    97. Oct-2 and Bob-1 deficiency in Hodgkin and Reed Sternberg cells. Cancer Res. 2001 Mar 01; 61(5):2080-4. Re D, Müschen M, Ahmadi T, Wickenhauser C, Staratschek-Jox A, Holtick U, Diehl V, Wolf J. PMID: 11280769.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    98. Molecular single-cell analysis of Hodgkin- and Reed-Sternberg cells harboring unmutated immunoglobulin variable region genes. Lab Invest. 2001 Mar; 81(3):289-95. Müschen M, Küppers R, Spieker T, Bräuninger A, Rajewsky K, Hansmann ML. PMID: 11310822.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    99. Evidence that Hodgkin and Reed-Sternberg cells in Hodgkin disease do not represent cell fusions. Blood. 2001 Feb 01; 97(3):818-21. Küppers R, Bräuninger A, Müschen M, Distler V, Hansmann ML, Rajewsky K. PMID: 11157505.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    100. Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction. J Exp Med. 2000 Dec 18; 192(12):1833-40. Müschen M, Re D, Jungnickel B, Diehl V, Rajewsky K, Küppers R. PMID: 11120779; PMCID: PMC2213498.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    101. Somatic mutations of the CD95 gene in Hodgkin and Reed-Sternberg cells. Cancer Res. 2000 Oct 15; 60(20):5640-3. Müschen M, Re D, Bräuninger A, Wolf J, Hansmann ML, Diehl V, Küppers R, Rajewsky K. PMID: 11059754.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    102. CD95 ligand expression as a criterion of malignant transformation in breast cancer. J Pathol. 2000 Aug; 191(4):468-70. Müschen M, Beckmann MW. PMID: 10918226.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    103. Rare occurrence of classical Hodgkin's disease as a T cell lymphoma. J Exp Med. 2000 Jan 17; 191(2):387-94. Müschen M, Rajewsky K, Bräuninger A, Baur AS, Oudejans JJ, Roers A, Hansmann ML, Küppers R. PMID: 10637283; PMCID: PMC2195757.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    104. Defining CD95 as a tumor suppressor gene. J Mol Med (Berl). 2000; 78(6):312-25. Müschen M, Warskulat U, Beckmann MW. PMID: 11001528.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    105. CD95 ligand expression as a mechanism of immune escape in breast cancer. Immunology. 2000 Jan; 99(1):69-77. Müschen M, Moers C, Warskulat U, Even J, Niederacher D, Beckmann MW. PMID: 10651943; PMCID: PMC2327134.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    106. CD95 ligand expression in dedifferentiated breast cancer. J Pathol. 1999 Nov; 189(3):378-86. Müschen M, Moers C, Warskulat U, Niederacher D, Betz B, Even J, Lim A, Josien R, Beckmann MW, Häussinger D. PMID: 10547600.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    107. Involvement of soluble CD95 in Churg-Strauss syndrome. Am J Pathol. 1999 Sep; 155(3):915-25. Müschen M, Warskulat U, Perniok A, Even J, Moers C, Kismet B, Temizkan N, Simon D, Schneider M, Häussinger D. PMID: 10487849; PMCID: PMC1866905.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    108. Involvement of CD95 (Apo-1/Fas) ligand expressed by rat Kupffer cells in hepatic immunoregulation. Gastroenterology. 1999 Mar; 116(3):666-77. Müschen M, Warskulat U, Peters-Regehr T, Bode JG, Kubitz R, Häussinger D. PMID: 10029626.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    109. Regulation of CD95 (Apo-1/Fas) ligand and receptor expression in squamous-cell carcinoma by interferon-gamma and cisplatin. Int J Cancer. 1999 Feb 09; 80(4):564-72. Moers C, Warskulat U, Müschen M, Even J, Niederacher D, Josien R, Koldovsky U, Beckmann MW, Häussinger D. PMID: 9935158.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    110. A critical role for transforming growth factor-beta in donor transfusion-induced allograft tolerance. J Clin Invest. 1998 Dec 01; 102(11):1920-6. Josien R, Douillard P, Guillot C, Müschen M, Anegon I, Chetritt J, Menoret S, Vignes C, Soulillou JP, Cuturi MC. PMID: 9835616; PMCID: PMC509143.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    111. Deranged CD95 system in a case of Churg-Strauss vasculitis. Gastroenterology. 1998 Jun; 114(6):1351-2. Müschen M, Warskulat U, Häussinger D, Moers C, Simon D, Even J. PMID: 9618660.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    112. Regulation of CD95 (APO-1/Fas) receptor and ligand expression by lipopolysaccharide and dexamethasone in parenchymal and nonparenchymal rat liver cells. Hepatology. 1998 Jan; 27(1):200-8. Müschen M, Warskulat U, Douillard P, Gilbert E, Häussinger D. PMID: 9425938.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
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