Saptarsi Haldar, MD
|School||UCSF School of Medicine|
San Francisco CA 94107
|Johns Hopkins University||M.D.||2000|
|Johns Hopkins University||Olser Medical Residency||Internal Medicine||2003|
|Brigham and Women's Hospital, Harvard Medical School||Fellowship in Cardiovascular Medicine||2006|
|2009||Jeremiah Stamler Distinguished Young Investigator Award, Northwestern Univ. YI Competition|
|2012||ASCI Best Research Poster Award|
|2013||Hartwell Foundation Biomedical Research Award|
|2014||Science Translational Medicine, Associate Scientific Advisory Board|
Clinical: I am a cardiologist specializing in general adult cardiology.
Research: I am a principal investigator at the Gladstone Institute of Cardiovascular Disease and the University of California, San Francisco. My scientific focus is to understand gene-regulatory and epigenetic mechanisms governing cell state transitions in the cardiovascular system and in skeletal muscle with an ultimate goal of finding novel therapeutic strategies to prevent and treat heart failure, cardiometabolic, and myopathic diseases.
A major focus of our team is in the pathobiology of heart failure, a devastating disease for which morbidity and mortality remain extremely high despite current standards of medical care. As a practicing physician-scientist that recognizes this major unmet need, one of my laboratory’s central goals is to discover novel mechanisms underlying heart failure pathogenesis and to develop new therapeutic strategies for this extremely common and lethal condition. We have a deep interest in the very nascent area of cardiovascular epigenetics and seek to unravel how chromatin-dependent signal transduction drives cardiovascular plasticity during physiological and pathophysiological states. As epigenetic regulators and chromatin-associated proteins are often tractable drug targets, we actively seek to translate our findings into novel transcriptionally-active cardiovascular therapeutics.
cardiovascular biology, skeletal muscle biology, heart failure, metabolism, exercise physiology, gene regulation, transcription, chromatin, epigenetics
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