Sheng Ding, PhD

SchoolUCSF School of Pharmacy
DepartmentPharmaceutical Chemistry
Address1500 Owens St.
San Francisco CA 94158
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    Collapse Biography 
    Collapse Awards and Honors
    California Institute of Technology2008New Faculty Award
    Prostate Cancer Foundation2008Challenge Award
    The Scientist Magazine2009#1 of Top 10 Innovations, and Top 5 People in 2009
    Pharma Voice2010One of the Most Inspiring People in the Life Sciences Industry
    NIH2010Transformative R01
    San Francisco Business Times201240 Under 40 Emerging Leaders

    Collapse Overview 
    Collapse Overview
    Dr. Sheng Ding is currently William K. Bowes, Jr. Distinguished Investigator and Professor at Gladstone Institute of Cardiovascular Disease, and Department of Pharmaceutical Chemistry, University of California San Francisco. He obtained his B.S. in chemistry with honors from Caltech in 1999, and a Ph.D. in chemistry from The Scripps Research Institute in 2003. Before moving to Gladstone/UCSF in early 2011, Ding was an Assistant Professor and then Associate Professor of Chemistry at Scripps from 2003 to 2011. Dr. Ding has pioneered on developing and applying innovative chemical approaches to stem cell biology and regeneration, with a focus on discovering and characterizing novel small molecules that can control various cell fate/function, including stem cell maintenance, activation, differentiation and reprogramming in various developmental stages and tissues. Ding has published over 100 research articles, reviews and book chapters, and made several seminal contributions to the stem cell field. Ding is a cofounder of Fate Therapeutics and Stemgent.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Liu K, Yu C, Xie M, Li K, Ding S. Chemical Modulation of Cell Fate in Stem Cell Therapeutics and Regenerative Medicine. Cell Chem Biol. 2016 Aug 18; 23(8):893-916. PMID: 27524294.
      View in: PubMed
    2. Zhang M, Lin YH, Sun YJ, Zhu S, Zheng J, Liu K, Cao N, Li K, Huang Y, Ding S. Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation. Cell Stem Cell. 2016 May 5; 18(5):653-67. PMID: 27133794.
      View in: PubMed
    3. Cao N, Huang Y, Zheng J, Spencer CI, Zhang Y, Fu JD, Nie B, Xie M, Zhang M, Wang H, Ma T, Xu T, Shi G, Srivastava D, Ding S. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 2016 Jun 3; 352(6290):1216-20. PMID: 27127239.
      View in: PubMed
    4. Zhang Y, Cao N, Huang Y, Spencer CI, Fu JD, Yu C, Liu K, Nie B, Xu T, Li K, Xu S, Bruneau BG, Srivastava D, Ding S. Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts. Cell Stem Cell. 2016 Mar 3; 18(3):368-81. PMID: 26942852.
      View in: PubMed
    5. Zhu S, Russ HA, Wang X, Zhang M, Ma T, Xu T, Tang S, Hebrok M, Ding S. Human pancreatic beta-like cells converted from fibroblasts. Nat Commun. 2016; 7:10080. PMID: 26733021.
      View in: PubMed
    6. Yu C, Liu K, Tang S, Ding S. Chemical approaches to cell reprogramming. Curr Opin Genet Dev. 2014 Oct; 28:50-6. PMID: 25461450.
      View in: PubMed
    7. Li K, Zhu S, Russ HA, Xu S, Xu T, Zhang Y, Ma T, Hebrok M, Ding S. Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages. Cell Stem Cell. 2014 Feb 6; 14(2):228-36. PMID: 24506886.
      View in: PubMed
    8. Zhu S, Ambasudhan R, Sun W, Kim HJ, Talantova M, Wang X, Zhang M, Zhang Y, Laurent T, Parker J, Kim HS, Zaremba JD, Saleem S, Sanz-Blasco S, Masliah E, McKercher SR, Cho YS, Lipton SA, Kim J, Ding S. Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells. Cell Res. 2014 Jan; 24(1):126-9. PMID: 24296783; PMCID: PMC3879704.
    9. Calvanese V, Chavez L, Laurent T, Ding S, Verdin E. Dual-color HIV reporters trace a population of latently infected cells and enable their purification. Virology. 2013 Nov; 446(1-2):283-92. PMID: 24074592; PMCID: PMC4019006.
    10. Fu JD, Stone NR, Liu L, Spencer CI, Qian L, Hayashi Y, Delgado-Olguin P, Ding S, Bruneau BG, Srivastava D. Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state. Stem Cell Reports. 2013; 1(3):235-47. PMID: 24319660; PMCID: PMC3849259.
    11. Lin C, Yu C, Ding S. Toward directed reprogramming through exogenous factors. Curr Opin Genet Dev. 2013 Oct; 23(5):519-25. PMID: 23932127; PMCID: PMC3790470.
    12. Xu T, Zhang M, Laurent T, Xie M, Ding S. Concise review: chemical approaches for modulating lineage-specific stem cells and progenitors. Stem Cells Transl Med. 2013 May; 2(5):355-61. PMID: 23580542; PMCID: PMC3667559.
    13. Li J, Huang NF, Zou J, Laurent TJ, Lee JC, Okogbaa J, Cooke JP, Ding S. Conversion of human fibroblasts to functional endothelial cells by defined factors. Arterioscler Thromb Vasc Biol. 2013 Jun; 33(6):1366-75. PMID: 23520160; PMCID: PMC3898631.
    14. Ma T, Xie M, Laurent T, Ding S. Progress in the reprogramming of somatic cells. Circ Res. 2013 Feb 1; 112(3):562-74. PMID: 23371904; PMCID: PMC3790469.
    15. Zhang Y, Li W, Laurent T, Ding S. Small molecules, big roles -- the chemical manipulation of stem cell fate and somatic cell reprogramming. J Cell Sci. 2012 Dec 1; 125(Pt 23):5609-20. PMID: 23420199; PMCID: PMC4067267.
    16. Nie B, Wang H, Laurent T, Ding S. Cellular reprogramming: a small molecule perspective. Curr Opin Cell Biol. 2012 Dec; 24(6):784-92. PMID: 22959962; PMCID: PMC3790462.
    17. Liu K, Ding S. Target practice: modeling tumors with stem cells. Cell. 2012 Jun 8; 149(6):1185-7. PMID: 22682241.
      View in: PubMed
    18. Xu T, Wang X, Zhong B, Nurieva RI, Ding S, Dong C. Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein. J Biol Chem. 2011 Jul 1; 286(26):22707-10. PMID: 21566134; PMCID: PMC3123037.
    19. Peng CT, Yang ZC, Ding S. Prediction of retention indexes. II. Structure-retention index relationship on polar columns. J Chromatogr. 1991 Nov 8; 586(1):85-112. PMID: 1806557.
      View in: PubMed
    20. Peng CT, Ding SF, Hua RL, Yang ZC. Prediction of retention indexes. I. Structure-retention index relationship on apolar columns. J Chromatogr. 1988 Feb 5; 436(2):137-72. PMID: 3356761.
      View in: PubMed
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