Sheng Ding, PhD

Title(s)Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
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    Collapse Biography 
    Collapse Awards and Honors
    California Institute of Technology2008New Faculty Award
    Prostate Cancer Foundation2008Challenge Award
    The Scientist Magazine2009#1 of Top 10 Innovations, and Top 5 People in 2009
    Pharma Voice2010One of the Most Inspiring People in the Life Sciences Industry
    NIH2010Transformative R01
    San Francisco Business Times201240 Under 40 Emerging Leaders

    Collapse Overview 
    Collapse Overview
    Dr. Sheng Ding is currently William K. Bowes, Jr. Distinguished Investigator and Professor at Gladstone Institute of Cardiovascular Disease, and Department of Pharmaceutical Chemistry, University of California San Francisco. He obtained his B.S. in chemistry with honors from Caltech in 1999, and a Ph.D. in chemistry from The Scripps Research Institute in 2003. Before moving to Gladstone/UCSF in early 2011, Ding was an Assistant Professor and then Associate Professor of Chemistry at Scripps from 2003 to 2011. Dr. Ding has pioneered on developing and applying innovative chemical approaches to stem cell biology and regeneration, with a focus on discovering and characterizing novel small molecules that can control various cell fate/function, including stem cell maintenance, activation, differentiation and reprogramming in various developmental stages and tissues. Ding has published over 100 research articles, reviews and book chapters, and made several seminal contributions to the stem cell field. Ding is a cofounder of Fate Therapeutics and Stemgent.

    Collapse Research 
    Collapse Research Activities and Funding
    Regeneration of Retinal Neurons by Chemically Induced Reprogramming of Muller Gli
    NIH/NEI R01EY021374Sep 30, 2010 - Aug 31, 2015
    Role: Co-Principal Investigator
    Generation of human iPS cells by chemically defined conditions
    NIH/NICHD R01HD064610Sep 17, 2010 - Aug 31, 2015
    Role: Principal Investigator
    Small molecules that maintain self-renewal of hESCs without growth factors
    NIH/NICHD R21HD060943Sep 30, 2009 - Feb 29, 2012
    Role: Co-Principal Investigator
    Small molecules that induce/promote generation of iPS cells
    NIH/NICHD R21HD060890May 1, 2009 - Apr 30, 2011
    Role: Principal Investigator
    Reprogramming of human neural cells to embryonic stem cells
    NIH/NICHD R21HD058110Apr 1, 2008 - Mar 31, 2011
    Role: Principal Investigator
    Directing hESCs Toward Cardiac Precursors
    NIH/NHLBI R21HL084295Jan 1, 2007 - Dec 31, 2008
    Role: Principal Investigator
    Directed Differentiation of hESCs into Early Pancreatic Precursors
    NIH/NICHD R21HD053759Aug 1, 2006 - Jul 31, 2008
    Role: Principal Investigator
    Small Molecules Directing DA Neuron Differentiation
    NIH/NINDS R21NS051452Feb 15, 2005 - Jan 31, 2007
    Role: Principal Investigator
    Dedifferentiation of Lineage Committed Cells
    NIH/NICHD R21HD047452Aug 1, 2004 - Jul 31, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yang B, Tang S, Ma C, Li ST, Shao GC, Dang B, DeGrado WF, Dong MQ, Wang PG, Ding S, Wang L. Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions. Nat Commun. 2017 12 21; 8(1):2240. PMID: 29269770.
      View in: PubMed
    2. Wang C, Ward ME, Chen R, Liu K, Tracy TE, Chen X, Xie M, Sohn PD, Ludwig C, Meyer-Franke A, Karch CM, Ding S, Gan L. Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening. Stem Cell Reports. 2017 10 10; 9(4):1221-1233. PMID: 28966121.
      View in: PubMed
    3. Nie B, Nie T, Hui X, Gu P, Mao L, Li K, Yuan R, Zheng J, Wang H, Li K, Tang S, Zhang Y, Xu T, Xu A, Wu D, Ding S. Brown Adipogenic Reprogramming Induced by a Small Molecule. Cell Rep. 2017 01 17; 18(3):624-635. PMID: 28099842.
      View in: PubMed
    4. Mohamed TM, Stone NR, Berry EC, Radzinsky E, Huang Y, Pratt K, Ang YS, Yu P, Wang H, Tang S, Magnitsky S, Ding S, Ivey KN, Srivastava D. Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming. Circulation. 2017 Mar 07; 135(10):978-995. PMID: 27834668.
      View in: PubMed
    5. Liu K, Yu C, Xie M, Li K, Ding S. Chemical Modulation of Cell Fate in Stem Cell Therapeutics and Regenerative Medicine. Cell Chem Biol. 2016 Aug 18; 23(8):893-916. PMID: 27524294.
      View in: PubMed
    6. Cao N, Huang Y, Zheng J, Spencer CI, Zhang Y, Fu JD, Nie B, Xie M, Zhang M, Wang H, Ma T, Xu T, Shi G, Srivastava D, Ding S. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 2016 Jun 03; 352(6290):1216-20. PMID: 27127239.
      View in: PubMed
    7. Zhang M, Lin YH, Sun YJ, Zhu S, Zheng J, Liu K, Cao N, Li K, Huang Y, Ding S. Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation. Cell Stem Cell. 2016 05 05; 18(5):653-67. PMID: 27133794.
      View in: PubMed
    8. Zhang Y, Cao N, Huang Y, Spencer CI, Fu JD, Yu C, Liu K, Nie B, Xu T, Li K, Xu S, Bruneau BG, Srivastava D, Ding S. Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts. Cell Stem Cell. 2016 Mar 03; 18(3):368-81. PMID: 26942852.
      View in: PubMed
    9. Zhu S, Russ HA, Wang X, Zhang M, Ma T, Xu T, Tang S, Hebrok M, Ding S. Human pancreatic beta-like cells converted from fibroblasts. Nat Commun. 2016 Jan 06; 7:10080. PMID: 26733021.
      View in: PubMed
    10. Yu C, Liu K, Tang S, Ding S. Chemical approaches to cell reprogramming. Curr Opin Genet Dev. 2014 Oct; 28:50-56. PMID: 25461450; PMCID: PMC4747244.
    11. Li K, Zhu S, Russ HA, Xu S, Xu T, Zhang Y, Ma T, Hebrok M, Ding S. Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages. Cell Stem Cell. 2014 Feb 06; 14(2):228-36. PMID: 24506886; PMCID: PMC4747235.
    12. Zhu S, Ambasudhan R, Sun W, Kim HJ, Talantova M, Wang X, Zhang M, Zhang Y, Laurent T, Parker J, Kim HS, Zaremba JD, Saleem S, Sanz-Blasco S, Masliah E, McKercher SR, Cho YS, Lipton SA, Kim J, Ding S. Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells. Cell Res. 2014 Jan; 24(1):126-9. PMID: 24296783; PMCID: PMC3879704.
    13. Calvanese V, Chavez L, Laurent T, Ding S, Verdin E. Dual-color HIV reporters trace a population of latently infected cells and enable their purification. Virology. 2013 Nov; 446(1-2):283-92. PMID: 24074592; PMCID: PMC4019006.
    14. Fu JD, Stone NR, Liu L, Spencer CI, Qian L, Hayashi Y, Delgado-Olguin P, Ding S, Bruneau BG, Srivastava D. Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state. Stem Cell Reports. 2013; 1(3):235-47. PMID: 24319660; PMCID: PMC3849259.
    15. Lin C, Yu C, Ding S. Toward directed reprogramming through exogenous factors. Curr Opin Genet Dev. 2013 Oct; 23(5):519-25. PMID: 23932127; PMCID: PMC3790470.
    16. Xu T, Zhang M, Laurent T, Xie M, Ding S. Concise review: chemical approaches for modulating lineage-specific stem cells and progenitors. Stem Cells Transl Med. 2013 May; 2(5):355-61. PMID: 23580542; PMCID: PMC3667559.
    17. Li J, Huang NF, Zou J, Laurent TJ, Lee JC, Okogbaa J, Cooke JP, Ding S. Conversion of human fibroblasts to functional endothelial cells by defined factors. Arterioscler Thromb Vasc Biol. 2013 Jun; 33(6):1366-75. PMID: 23520160; PMCID: PMC3898631.
    18. Ma T, Xie M, Laurent T, Ding S. Progress in the reprogramming of somatic cells. Circ Res. 2013 Feb 01; 112(3):562-74. PMID: 23371904; PMCID: PMC3790469.
    19. Zhang Y, Li W, Laurent T, Ding S. Small molecules, big roles -- the chemical manipulation of stem cell fate and somatic cell reprogramming. J Cell Sci. 2012 Dec 01; 125(Pt 23):5609-20. PMID: 23420199; PMCID: PMC4067267.
    20. Nie B, Wang H, Laurent T, Ding S. Cellular reprogramming: a small molecule perspective. Curr Opin Cell Biol. 2012 Dec; 24(6):784-92. PMID: 22959962; PMCID: PMC3790462.
    21. Liu K, Ding S. Target practice: modeling tumors with stem cells. Cell. 2012 Jun 08; 149(6):1185-7. PMID: 22682241.
      View in: PubMed
    22. Xu T, Wang X, Zhong B, Nurieva RI, Ding S, Dong C. Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein. J Biol Chem. 2011 Jul 01; 286(26):22707-10. PMID: 21566134; PMCID: PMC3123037.
    23. Peng CT, Yang ZC, Ding SF. Prediction of retention indexes. II. Structure-retention index relationship on polar columns. J Chromatogr. 1991 Nov 08; 586(1):85-112. PMID: 1806557.
      View in: PubMed
    24. Peng CT, Ding SF, Hua RL, Yang ZC. Prediction of retention indexes. I. Structure-retention index relationship on apolar columns. J Chromatogr. 1988 Feb 05; 436(2):137-72. PMID: 3356761.
      View in: PubMed