Loading...

Sheng Ding, PhD

Title(s)Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address1500 Owens St.
San Francisco CA 94158
Phone415-734-2717
vCardDownload vCard

    Collapse Biography 
    Collapse Awards and Honors
    California Institute of Technology2008New Faculty Award
    Prostate Cancer Foundation2008Challenge Award
    The Scientist Magazine2009#1 of Top 10 Innovations, and Top 5 People in 2009
    Pharma Voice2010One of the Most Inspiring People in the Life Sciences Industry
    NIH2010Transformative R01
    San Francisco Business Times201240 Under 40 Emerging Leaders

    Collapse Overview 
    Collapse Overview
    Dr. Sheng Ding is currently William K. Bowes, Jr. Distinguished Investigator and Professor at Gladstone Institute of Cardiovascular Disease, and Department of Pharmaceutical Chemistry, University of California San Francisco. He obtained his B.S. in chemistry with honors from Caltech in 1999, and a Ph.D. in chemistry from The Scripps Research Institute in 2003. Before moving to Gladstone/UCSF in early 2011, Ding was an Assistant Professor and then Associate Professor of Chemistry at Scripps from 2003 to 2011. Dr. Ding has pioneered on developing and applying innovative chemical approaches to stem cell biology and regeneration, with a focus on discovering and characterizing novel small molecules that can control various cell fate/function, including stem cell maintenance, activation, differentiation and reprogramming in various developmental stages and tissues. Ding has published over 100 research articles, reviews and book chapters, and made several seminal contributions to the stem cell field. Ding is a cofounder of Fate Therapeutics and Stemgent.

    Collapse Research 
    Collapse Research Activities and Funding
    Regeneration of Retinal Neurons by Chemically Induced Reprogramming of Muller Gli
    NIH/NEI R01EY021374Sep 30, 2010 - Aug 31, 2015
    Role: Co-Principal Investigator
    Generation of human iPS cells by chemically defined conditions
    NIH/NICHD R01HD064610Sep 17, 2010 - Mar 31, 2011
    Role: Principal Investigator
    Small molecules that maintain self-renewal of hESCs without growth factors
    NIH/NICHD R21HD060943Sep 30, 2009 - Feb 29, 2012
    Role: Co-Principal Investigator
    Small molecules that induce/promote generation of iPS cells
    NIH/NICHD R21HD060890May 1, 2009 - Apr 30, 2011
    Role: Principal Investigator
    Reprogramming of human neural cells to embryonic stem cells
    NIH/NICHD R21HD058110Apr 1, 2008 - Mar 31, 2011
    Role: Principal Investigator
    Directing hESCs Toward Cardiac Precursors
    NIH/NHLBI R21HL084295Jan 1, 2007 - Dec 31, 2008
    Role: Principal Investigator
    Directed Differentiation of hESCs into Early Pancreatic Precursors
    NIH/NICHD R21HD053759Aug 1, 2006 - Jul 31, 2008
    Role: Principal Investigator
    Small Molecules Directing DA Neuron Differentiation
    NIH/NINDS R21NS051452Feb 15, 2005 - Jan 31, 2007
    Role: Principal Investigator
    Dedifferentiation of Lineage Committed Cells
    NIH/NICHD R21HD047452Aug 1, 2004 - Jul 31, 2006
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Scientific considerations for global drug development. Sci Transl Med. 2020 Jul 29; 12(554). Wilson JL, Cheung KWK, Lin L, Green EAE, Porrás AI, Zou L, Mukanga D, Akpa PA, Darko DM, Yuan R, Ding S, Johnson WCN, Lee HA, Cooke E, Peck CC, Kern SE, Hartman D, Hayashi Y, Marks PW, Altman RB, Lumpkin MM, Giacomini KM, Blaschke TF. PMID: 32727913.
      View in: PubMed   Mentions:    Fields:    
    2. Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions. Nat Commun. 2017 12 21; 8(1):2240. Yang B, Tang S, Ma C, Li ST, Shao GC, Dang B, DeGrado WF, Dong MQ, Wang PG, Ding S, Wang L. PMID: 29269770.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    3. Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening. Stem Cell Reports. 2017 10 10; 9(4):1221-1233. Wang C, Ward ME, Chen R, Liu K, Tracy TE, Chen X, Xie M, Sohn PD, Ludwig C, Meyer-Franke A, Karch CM, Ding S, Gan L. PMID: 28966121.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    4. Brown Adipogenic Reprogramming Induced by a Small Molecule. Cell Rep. 2017 01 17; 18(3):624-635. Nie B, Nie T, Hui X, Gu P, Mao L, Li K, Yuan R, Zheng J, Wang H, Li K, Tang S, Zhang Y, Xu T, Xu A, Wu D, Ding S. PMID: 28099842.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    5. Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming. Circulation. 2017 Mar 07; 135(10):978-995. Mohamed TM, Stone NR, Berry EC, Radzinsky E, Huang Y, Pratt K, Ang YS, Yu P, Wang H, Tang S, Magnitsky S, Ding S, Ivey KN, Srivastava D. PMID: 27834668.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    6. Chemical Modulation of Cell Fate in Stem Cell Therapeutics and Regenerative Medicine. Cell Chem Biol. 2016 Aug 18; 23(8):893-916. Liu K, Yu C, Xie M, Li K, Ding S. PMID: 27524294.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    7. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 2016 Jun 03; 352(6290):1216-20. Cao N, Huang Y, Zheng J, Spencer CI, Zhang Y, Fu JD, Nie B, Xie M, Zhang M, Wang H, Ma T, Xu T, Shi G, Srivastava D, Ding S. PMID: 27127239.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    8. Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation. Cell Stem Cell. 2016 05 05; 18(5):653-67. Zhang M, Lin YH, Sun YJ, Zhu S, Zheng J, Liu K, Cao N, Li K, Huang Y, Ding S. PMID: 27133794.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    9. Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts. Cell Stem Cell. 2016 Mar 03; 18(3):368-81. Zhang Y, Cao N, Huang Y, Spencer CI, Fu JD, Yu C, Liu K, Nie B, Xu T, Li K, Xu S, Bruneau BG, Srivastava D, Ding S. PMID: 26942852.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    10. Human pancreatic beta-like cells converted from fibroblasts. Nat Commun. 2016 Jan 06; 7:10080. Zhu S, Russ HA, Wang X, Zhang M, Ma T, Xu T, Tang S, Hebrok M, Ding S. PMID: 26733021.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    11. 458. Sensitizing Ovarian Cancer Cells To Chemotherapy By Interfering With Pathways That Are Involved in the Formation and Maintenance of Cancer Stem Cells. Molecular Therapy. 2015 May 1; 23:s182. Kamola Saydaminova, Robert Strauss, Min Xie, Charles Dreshner, Sheng Ding, Andre Lieber. .
      View in: Publisher Site   Mentions:
    12. Chapter 4 Chemical Approaches to Controlling Cell Fate. Principles of Developmental Genetics. 2015 Jan 1; (Cell Stem Cell462009):59-76. Mingliang Zhang, Ke Li, Min Xie, Sheng Ding. .
      View in: Publisher Site   Mentions:
    13. Chemical approaches to cell reprogramming. Curr Opin Genet Dev. 2014 Oct; 28:50-56. Yu C, Liu K, Tang S, Ding S. PMID: 25461450.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    14. Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages. Cell Stem Cell. 2014 Feb 06; 14(2):228-36. Li K, Zhu S, Russ HA, Xu S, Xu T, Zhang Y, Ma T, Hebrok M, Ding S. PMID: 24506886.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    15. Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells. Cell Res. 2014 Jan; 24(1):126-9. Zhu S, Ambasudhan R, Sun W, Kim HJ, Talantova M, Wang X, Zhang M, Zhang Y, Laurent T, Parker J, Kim HS, Zaremba JD, Saleem S, Sanz-Blasco S, Masliah E, McKercher SR, Cho YS, Lipton SA, Kim J, Ding S. PMID: 24296783.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    16. Dual-color HIV reporters trace a population of latently infected cells and enable their purification. Virology. 2013 Nov; 446(1-2):283-92. Calvanese V, Chavez L, Laurent T, Ding S, Verdin E. PMID: 24074592.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    17. Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state. Stem Cell Reports. 2013; 1(3):235-47. Fu JD, Stone NR, Liu L, Spencer CI, Qian L, Hayashi Y, Delgado-Olguin P, Ding S, Bruneau BG, Srivastava D. PMID: 24319660.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansAnimalsCells
    18. Toward directed reprogramming through exogenous factors. Curr Opin Genet Dev. 2013 Oct; 23(5):519-25. Lin C, Yu C, Ding S. PMID: 23932127.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    19. Concise review: chemical approaches for modulating lineage-specific stem cells and progenitors. Stem Cells Transl Med. 2013 May; 2(5):355-61. Xu T, Zhang M, Laurent T, Xie M, Ding S. PMID: 23580542.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    20. Conversion of human fibroblasts to functional endothelial cells by defined factors. Arterioscler Thromb Vasc Biol. 2013 Jun; 33(6):1366-75. Li J, Huang NF, Zou J, Laurent TJ, Lee JC, Okogbaa J, Cooke JP, Ding S. PMID: 23520160.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    21. Progress in the reprogramming of somatic cells. Circ Res. 2013 Feb 01; 112(3):562-74. Ma T, Xie M, Laurent T, Ding S. PMID: 23371904.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    22. Small molecules, big roles -- the chemical manipulation of stem cell fate and somatic cell reprogramming. J Cell Sci. 2012 Dec 01; 125(Pt 23):5609-20. Zhang Y, Li W, Laurent T, Ding S. PMID: 23420199.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    23. Cellular reprogramming: a small molecule perspective. Curr Opin Cell Biol. 2012 Dec; 24(6):784-92. Nie B, Wang H, Laurent T, Ding S. PMID: 22959962.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    24. Target practice: modeling tumors with stem cells. Cell. 2012 Jun 08; 149(6):1185-7. Liu K, Ding S. PMID: 22682241.
      View in: PubMed   Mentions: 1     Fields:    
    25. Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein. J Biol Chem. 2011 Jul 01; 286(26):22707-10. Xu T, Wang X, Zhong B, Nurieva RI, Ding S, Dong C. PMID: 21566134.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    26. Small Molecules in Cellular Reprogramming and Differentiation. Epigenetics and Disease. 2011 Jan 1; 253-266. Xu Yuan, Wenlin Li, Sheng Ding. .
      View in: Publisher Site   Mentions:
    27. Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins. Cell Stem Cell. 2009 Jun 1; 4(6):581. Hongyan Zhou, Shili Wu, Jin Young Joo, Saiyong Zhu, Dong Wook Han, Tongxiang Lin, Sunia Trauger, Geoffery Bien, Susan Yao, Yong Zhu, Gary Siuzdak, Hans R. Schöler, Lingxun Duan, Sheng Ding. .
      View in: Publisher Site   Mentions:
    28. Generation of Rat and Human Induced Pluripotent Stem Cells by Combining Genetic Reprogramming and Chemical Inhibitors. Cell Stem Cell. 2009 Apr 1; 4(4):370. Wenlin Li, Wei Wei, Saiyong Zhu, Jinliang Zhu, Yan Shi, Tongxiang Lin, Ergeng Hao, Alberto Hayek, Hongkui Deng, Sheng Ding. .
      View in: Publisher Site   Mentions:
    29. A chemical approach to stem cell biology. Cell Research. 2008 Aug 1; 18(Suppl 1):s5-s5. Sheng Ding. .
      View in: Publisher Site   Mentions:
    30. A Combined Chemical and Genetic Approach for the Generation of Induced Pluripotent Stem Cells. Cell Stem Cell. 2008 Jul 1; 3(1):119. Yan Shi, Jeong Tae, Caroline Desponts, Heung Sik Hahm, Hans R. Schöler, Sheng Ding. .
      View in: Publisher Site   Mentions:
    31. Stem Cell Fates: Control by Small Molecules. Wiley Encyclopedia of Chemical Biology. 2008 May 15; 1-8. Simon Hilcove, Yue Xu, Sheng Ding. .
      View in: Publisher Site   Mentions:
    32. Exploring Stem Cell Biology with Small Molecules and Functional Genomics. Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine. 2008 Apr 11; 187-206. Julie Clark, Yue Xu, Simon Hilcove, Sheng Ding. .
      View in: Publisher Site   Mentions:
    33. 2 TARGET VALIDATION IN CHEMOGENOMICS. Target Validation in Drug Discovery. 2007 Jan 1; (Nat. Biotechnol.202002):27-39. TOM Y-H. WU, SHENG DING. .
      View in: Publisher Site   Mentions:
    34. GSK-3 and Stem Cells. Glycogen Synthase Kinase 3 (GSK-3) and Its Inhibitors. 2006 Oct 23; 155-171. Shuibing Chen, Sheng Ding. .
      View in: Publisher Site   Mentions:
    35. A Synthetic Small Molecule That Induces Neuronal Differentiation of Adult Hippocampal Neural Progenitor Cells. Angewandte Chemie. 2006 Jan 16; 118(4):605-607. Masaki Warashina, Kyung Hoon Min, Tomoko Kuwabara, Alexis Huynh, Fred H. Gage, Peter G. Schultz, Sheng Ding. .
      View in: Publisher Site   Mentions:
    36. A Small-Molecule Agonist of the Wnt Signaling Pathway. Angewandte Chemie. 2005 Mar 18; 117(13):2023-2026. Jun Liu, Xu Wu, Brian Mitchell, Chris Kintner, Sheng Ding, Peter G. Schultz. .
      View in: Publisher Site   Mentions:
    37. One-Pot Two-Step Microwave-Assisted Reaction in Constructing 4,5-Disubstituted Pyrazolopyrimidines. ChemInform. 2004 Feb 3; 35(5). Tom Y. H. Wu, Peter G. Schultz, Sheng Ding. .
      View in: Publisher Site   Mentions:
    38. ChemInform Abstract: Expanding the Diversity of Purine Libraries. ChemInform. 2002 Mar 12; 33(10):no-no. Sheng Ding, Nathanael S. Gray, Qiang Ding, Peter G. Schultz. .
      View in: Publisher Site   Mentions:
    39. Expanding the diversity of purine libraries. Tetrahedron Letters. 2001 Dec 1; 42(50):8751-8755. Sheng Ding, Nathanael S Gray, Qiang Ding, Peter G Schultz. .
      View in: Publisher Site   Mentions:
    40. Prediction of retention indexes. II. Structure-retention index relationship on polar columns. J Chromatogr. 1991 Nov 08; 586(1):85-112. Peng CT, Yang ZC, Ding SF. PMID: 1806557.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    41. Prediction of retention indexes. I. Structure-retention index relationship on apolar columns. J Chromatogr. 1988 Feb 05; 436(2):137-72. Peng CT, Ding SF, Hua RL, Yang ZC. PMID: 3356761.
      View in: PubMed   Mentions:    Fields:    
    Sheng's Networks
    Concepts (161)
    Derived automatically from this person's publications.
    _
    Co-Authors (18)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _