Sheng Ding, PhD

Title(s)Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
AddressLocation Required, #001
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    Collapse Biography 
    Collapse Awards and Honors
    California Institute of Technology2008New Faculty Award
    Prostate Cancer Foundation2008Challenge Award
    The Scientist Magazine2009#1 of Top 10 Innovations, and Top 5 People in 2009
    Pharma Voice2010One of the Most Inspiring People in the Life Sciences Industry
    NIH2010Transformative R01
    San Francisco Business Times201240 Under 40 Emerging Leaders

    Collapse Overview 
    Collapse Overview
    Dr. Sheng Ding is currently William K. Bowes, Jr. Distinguished Investigator and Professor at Gladstone Institute of Cardiovascular Disease, and Department of Pharmaceutical Chemistry, University of California San Francisco. He obtained his B.S. in chemistry with honors from Caltech in 1999, and a Ph.D. in chemistry from The Scripps Research Institute in 2003. Before moving to Gladstone/UCSF in early 2011, Ding was an Assistant Professor and then Associate Professor of Chemistry at Scripps from 2003 to 2011. Dr. Ding has pioneered on developing and applying innovative chemical approaches to stem cell biology and regeneration, with a focus on discovering and characterizing novel small molecules that can control various cell fate/function, including stem cell maintenance, activation, differentiation and reprogramming in various developmental stages and tissues. Ding has published over 100 research articles, reviews and book chapters, and made several seminal contributions to the stem cell field. Ding is a cofounder of Fate Therapeutics and Stemgent.

    Collapse Research 
    Collapse Research Activities and Funding
    Regeneration of Retinal Neurons by Chemically Induced Reprogramming of Muller Gli
    NIH R01EY021374Sep 30, 2010 - Aug 31, 2015
    Role: Co-Principal Investigator
    Generation of human iPS cells by chemically defined conditions
    NIH R01HD064610Sep 17, 2010 - Aug 31, 2015
    Role: Principal Investigator
    Small molecules that maintain self-renewal of hESCs without growth factors
    NIH R21HD060943Sep 30, 2009 - Feb 29, 2012
    Role: Co-Principal Investigator
    Small molecules that induce/promote generation of iPS cells
    NIH R21HD060890May 1, 2009 - Apr 30, 2011
    Role: Principal Investigator
    Reprogramming of human neural cells to embryonic stem cells
    NIH R21HD058110Apr 1, 2008 - Mar 31, 2011
    Role: Principal Investigator
    Directing hESCs Toward Cardiac Precursors
    NIH R21HL084295Jan 1, 2007 - Dec 31, 2008
    Role: Principal Investigator
    Directed Differentiation of hESCs into Early Pancreatic Precursors
    NIH R21HD053759Aug 1, 2006 - Jul 31, 2008
    Role: Principal Investigator
    Small Molecules Directing DA Neuron Differentiation
    NIH R21NS051452Feb 15, 2005 - Jan 31, 2007
    Role: Principal Investigator
    Dedifferentiation of Lineage Committed Cells
    NIH R21HD047452Aug 1, 2004 - Jul 31, 2006
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A DNA repair pathway can regulate transcriptional noise to promote cell fate transitions. Science. 2021 08 20; 373(6557). Desai RV, Chen X, Martin B, Chaturvedi S, Hwang DW, Li W, Yu C, Ding S, Thomson M, Singer RH, Coleman RA, Hansen MMK, Weinberger LS. PMID: 34301855; PMCID: PMC8667278.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    2. Scientific considerations for global drug development. Sci Transl Med. 2020 07 29; 12(554). Wilson JL, Cheung KWK, Lin L, Green EAE, Porrás AI, Zou L, Mukanga D, Akpa PA, Darko DM, Yuan R, Ding S, Johnson WCN, Lee HA, Cooke E, Peck CC, Kern SE, Hartman D, Hayashi Y, Marks PW, Altman RB, Lumpkin MM, Giacomini KM, Blaschke TF. PMID: 32727913; PMCID: PMC8158457.
      View in: PubMed   Mentions: 6     Fields:    
    3. Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions. Nat Commun. 2017 12 21; 8(1):2240. Yang B, Tang S, Ma C, Li ST, Shao GC, Dang B, DeGrado WF, Dong MQ, Wang PG, Ding S, Wang L. PMID: 29269770; PMCID: PMC5740110.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    4. Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening. Stem Cell Reports. 2017 10 10; 9(4):1221-1233. Wang C, Ward ME, Chen R, Liu K, Tracy TE, Chen X, Xie M, Sohn PD, Ludwig C, Meyer-Franke A, Karch CM, Ding S, Gan L. PMID: 28966121; PMCID: PMC5639430.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansCells
    5. Brown Adipogenic Reprogramming Induced by a Small Molecule. Cell Rep. 2017 01 17; 18(3):624-635. Nie B, Nie T, Hui X, Gu P, Mao L, Li K, Yuan R, Zheng J, Wang H, Li K, Tang S, Zhang Y, Xu T, Xu A, Wu D, Ding S. PMID: 28099842.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    6. Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming. Circulation. 2017 Mar 07; 135(10):978-995. Mohamed TM, Stone NR, Berry EC, Radzinsky E, Huang Y, Pratt K, Ang YS, Yu P, Wang H, Tang S, Magnitsky S, Ding S, Ivey KN, Srivastava D. PMID: 27834668; PMCID: PMC5340593.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansAnimalsCells
    7. Chemical Modulation of Cell Fate in Stem Cell Therapeutics and Regenerative Medicine. Cell Chem Biol. 2016 Aug 18; 23(8):893-916. Liu K, Yu C, Xie M, Li K, Ding S. PMID: 27524294.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    8. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 2016 Jun 03; 352(6290):1216-20. Cao N, Huang Y, Zheng J, Spencer CI, Zhang Y, Fu JD, Nie B, Xie M, Zhang M, Wang H, Ma T, Xu T, Shi G, Srivastava D, Ding S. PMID: 27127239.
      View in: PubMed   Mentions: 174     Fields:    Translation:HumansAnimalsCells
    9. Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation. Cell Stem Cell. 2016 05 05; 18(5):653-67. Zhang M, Lin YH, Sun YJ, Zhu S, Zheng J, Liu K, Cao N, Li K, Huang Y, Ding S. PMID: 27133794; PMCID: PMC4864020.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    10. Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts. Cell Stem Cell. 2016 Mar 03; 18(3):368-81. Zhang Y, Cao N, Huang Y, Spencer CI, Fu JD, Yu C, Liu K, Nie B, Xu T, Li K, Xu S, Bruneau BG, Srivastava D, Ding S. PMID: 26942852; PMCID: PMC5826660.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    11. Human pancreatic beta-like cells converted from fibroblasts. Nat Commun. 2016 Jan 06; 7:10080. Zhu S, Russ HA, Wang X, Zhang M, Ma T, Xu T, Tang S, Hebrok M, Ding S. PMID: 26733021; PMCID: PMC4729817.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    12. Abstract 11415: Enhancing Direct Cardiac Reprogramming Efficiency Using Small Molecules. Circulation. 2015 Nov 10; 132(suppl_3). Mohamed MT, Stone SN, Berry BE, Wang WH, Ding DS, Srivastava SD. .
      View in: Publisher Site   Mentions:
    13. 458. Sensitizing Ovarian Cancer Cells To Chemotherapy By Interfering With Pathways That Are Involved in the Formation and Maintenance of Cancer Stem Cells. Molecular Therapy. 2015 May 1; 23:s182. Saydaminova SK, Strauss SR, Xie XM, Dreshner DC, Ding DS, Lieber LA. .
      View in: Publisher Site   Mentions:
    14. Chapter 4 Chemical Approaches to Controlling Cell Fate. Principles of Developmental Genetics. 2015 Jan 1; (Cell Stem Cell462009):59-76. Zhang ZM, Li LK, Xie XM, Ding DS. .
      View in: Publisher Site   Mentions:
    15. Chemical approaches to cell reprogramming. Curr Opin Genet Dev. 2014 Oct; 28:50-56. Yu C, Liu K, Tang S, Ding S. PMID: 25461450; PMCID: PMC4747244.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    16. Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages. Cell Stem Cell. 2014 Feb 06; 14(2):228-36. Li K, Zhu S, Russ HA, Xu S, Xu T, Zhang Y, Ma T, Hebrok M, Ding S. PMID: 24506886; PMCID: PMC4747235.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    17. Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells. Cell Res. 2014 Jan; 24(1):126-9. Zhu S, Ambasudhan R, Sun W, Kim HJ, Talantova M, Wang X, Zhang M, Zhang Y, Laurent T, Parker J, Kim HS, Zaremba JD, Saleem S, Sanz-Blasco S, Masliah E, McKercher SR, Cho YS, Lipton SA, Kim J, Ding S. PMID: 24296783; PMCID: PMC3879704.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    18. Dual-color HIV reporters trace a population of latently infected cells and enable their purification. Virology. 2013 Nov; 446(1-2):283-92. Calvanese V, Chavez L, Laurent T, Ding S, Verdin E. PMID: 24074592; PMCID: PMC4019006.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    19. Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state. Stem Cell Reports. 2013; 1(3):235-47. Fu JD, Stone NR, Liu L, Spencer CI, Qian L, Hayashi Y, Delgado-Olguin P, Ding S, Bruneau BG, Srivastava D. PMID: 24319660; PMCID: PMC3849259.
      View in: PubMed   Mentions: 209     Fields:    Translation:HumansAnimalsCells
    20. Toward directed reprogramming through exogenous factors. Curr Opin Genet Dev. 2013 Oct; 23(5):519-25. Lin C, Yu C, Ding S. PMID: 23932127; PMCID: PMC3790470.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    21. Concise review: chemical approaches for modulating lineage-specific stem cells and progenitors. Stem Cells Transl Med. 2013 May; 2(5):355-61. Xu T, Zhang M, Laurent T, Xie M, Ding S. PMID: 23580542; PMCID: PMC3667559.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    22. Conversion of human fibroblasts to functional endothelial cells by defined factors. Arterioscler Thromb Vasc Biol. 2013 Jun; 33(6):1366-75. Li J, Huang NF, Zou J, Laurent TJ, Lee JC, Okogbaa J, Cooke JP, Ding S. PMID: 23520160; PMCID: PMC3898631.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    23. Progress in the reprogramming of somatic cells. Circ Res. 2013 Feb 01; 112(3):562-74. Ma T, Xie M, Laurent T, Ding S. PMID: 23371904; PMCID: PMC3790469.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    24. Small molecules, big roles -- the chemical manipulation of stem cell fate and somatic cell reprogramming. J Cell Sci. 2012 Dec 01; 125(Pt 23):5609-20. Zhang Y, Li W, Laurent T, Ding S. PMID: 23420199; PMCID: PMC4067267.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    25. Cellular reprogramming: a small molecule perspective. Curr Opin Cell Biol. 2012 Dec; 24(6):784-92. Nie B, Wang H, Laurent T, Ding S. PMID: 22959962; PMCID: PMC3790462.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    26. Target practice: modeling tumors with stem cells. Cell. 2012 Jun 08; 149(6):1185-7. Liu K, Ding S. PMID: 22682241.
      View in: PubMed   Mentions: 2     Fields:    
    27. Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein. J Biol Chem. 2011 Jul 01; 286(26):22707-10. Xu T, Wang X, Zhong B, Nurieva RI, Ding S, Dong C. PMID: 21566134; PMCID: PMC3123037.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    28. Small Molecules in Cellular Reprogramming and Differentiation. Epigenetics and Disease. 2011 Jan 1; 253-266. Yuan YX, Li LW, Ding DS. .
      View in: Publisher Site   Mentions:
    29. Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins. Cell Stem Cell. 2009 Jun 1; 4(6):581. Zhou ZH, Wu WS, Joo JJ, Zhu ZS, Han HD, Lin LT, Trauger TS, Bien BG, Yao YS, Zhu ZY, Siuzdak SG, Schöler SH, Duan DL, Ding DS. .
      View in: Publisher Site   Mentions:
    30. Generation of Rat and Human Induced Pluripotent Stem Cells by Combining Genetic Reprogramming and Chemical Inhibitors. Cell Stem Cell. 2009 Apr 1; 4(4):370. Li LW, Wei WW, Zhu ZS, Zhu ZJ, Shi SY, Lin LT, Hao HE, Hayek HA, Deng DH, Ding DS. .
      View in: Publisher Site   Mentions:
    31. A chemical approach to stem cell biology. Cell Research. 2008 Aug 1; 18(Suppl 1):s5-s5. Ding DS. .
      View in: Publisher Site   Mentions:
    32. A Combined Chemical and Genetic Approach for the Generation of Induced Pluripotent Stem Cells. Cell Stem Cell. 2008 Jul 1; 3(1):119. Shi SY, Tae TJ, Desponts DC, Hahm HH, Schöler SH, Ding DS. .
      View in: Publisher Site   Mentions:
    33. Stem Cell Fates: Control by Small Molecules. Wiley Encyclopedia of Chemical Biology. 2008 May 15; 1-8. Hilcove HS, Xu XY, Ding DS. .
      View in: Publisher Site   Mentions:
    34. Exploring Stem Cell Biology with Small Molecules and Functional Genomics. Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine. 2008 Apr 11; 187-206. Clark CJ, Xu XY, Hilcove HS, Ding DS. .
      View in: Publisher Site   Mentions:
    35. 2 TARGET VALIDATION IN CHEMOGENOMICS. Target Validation in Drug Discovery. 2007 Jan 1; (Nat. Biotechnol.202002):27-39. WU WT, DING DS. .
      View in: Publisher Site   Mentions:
    36. GSK-3 and Stem Cells. Glycogen Synthase Kinase 3 (GSK-3) and Its Inhibitors. 2006 Oct 23; 155-171. Chen CS, Ding DS. .
      View in: Publisher Site   Mentions:
    37. A Synthetic Small Molecule That Induces Neuronal Differentiation of Adult Hippocampal Neural Progenitor Cells. Angewandte Chemie. 2006 Jan 16; 118(4):605-607. Warashina WM, Min MK, Kuwabara KT, Huynh HA, Gage GF, Schultz SP, Ding DS. .
      View in: Publisher Site   Mentions:
    38. A Small-Molecule Agonist of the Wnt Signaling Pathway. Angewandte Chemie. 2005 Mar 18; 117(13):2023-2026. Liu LJ, Wu WX, Mitchell MB, Kintner KC, Ding DS, Schultz SP. .
      View in: Publisher Site   Mentions:
    39. One-Pot Two-Step Microwave-Assisted Reaction in Constructing 4,5-Disubstituted Pyrazolopyrimidines. ChemInform. 2004 Feb 3; 35(5). Wu WT, Schultz SP, Ding DS. .
      View in: Publisher Site   Mentions:
    40. ChemInform Abstract: Expanding the Diversity of Purine Libraries. ChemInform. 2002 Mar 12; 33(10):no-no. Ding DS, Gray GN, Ding DQ, Schultz SP. .
      View in: Publisher Site   Mentions:
    41. Expanding the diversity of purine libraries. Tetrahedron Letters. 2001 Dec 1; 42(50):8751-8755. Ding DS, Gray GN, Ding DQ, Schultz SP. .
      View in: Publisher Site   Mentions:
    42. Prediction of retention indexes. II. Structure-retention index relationship on polar columns. J Chromatogr. 1991 Nov 08; 586(1):85-112. Peng CT, Yang ZC, Ding SF. PMID: 1806557.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    43. Prediction of retention indexes. I. Structure-retention index relationship on apolar columns. J Chromatogr. 1988 Feb 05; 436(2):137-72. Peng CT, Ding SF, Hua RL, Yang ZC. PMID: 3356761.
      View in: PubMed   Mentions:    Fields:    
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