Shibani Pati, MD, PhD

TitleAssociate Prof. In Residence
SchoolUCSF School of Medicine
DepartmentLaboratory Medicine
Address513 Parnassus Ave
San Francisco CA 94143
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    Collapse Biography 
    Collapse Education and Training
    Princeton University, Princeton NJA.B.1992Molecular Biology
    University of Maryland School of Medicine, Baltimore, MDMD PhD2001Virology/Immunology
    Baylor College of Medicine and University of Texas Houston, Houston TXPostdoctoral Fellow2007Neurobiology

    Collapse Overview 
    Collapse Overview
    I am a vascular biologist with an interest in the role of endothelial dysfunction and vascular compromise in the pathogenesis of human disease. My specific areas of investigation involve the use of stem cell therapies and novel resuscitative modalities that can mitigate endothelial dysfunction and improve outcomes in traumatic injury. Areas of focus in the lab include traumatic brain injury (TBI), spinal cord injury (SCI), and hemorrhagic shock induced organ failure.

    Abnormalities in vascular permeability leading to inflammation, tissue edema, and end-organ dysfunction significantly contribute to the morbidity and mortality associated with a number of human disease processes. For example, although a number of factors contribute to the high mortality and morbidity associated with traumatic brain injury (TBI), the development of cerebral edema with brain swelling remains one of the most significant predictors of outcome. Similarly both hemorrhagic shock and septic shock are characterized by abnormal vascular permeability, which contributes to the development of shock-associated acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Despite the clear importance of abnormal vascular permeability in a number of human disease processes, there exists no therapeutic modality in current use to attenuate it. Our lab's focus is to understand the mechanisms of action that lead to organ failure in traumatic injury and to also discover novel therapies that improve outcomes.

    Collapse Research 
    Collapse Research Activities and Funding
    Mesenchymal Stem Cells for Treatment of ARDS Following Trauma
    Department of Defense PR160568Sep 30, 2017 - Sep 29, 2021
    Role: Co-Investigator
    Prothrombin Complex Concentrate for Prolonged Field Care of War Casualties
    Department of Defense DM160342Sep 30, 2017 - Sep 29, 2020
    Role: Co-Investigator
    Dried Plasma to Improve Outcomes in Polytrauma, Hemorrhage and Trauma Associated Sepsis (TAS): Novel Solutions for the Prolonged Field Care Environment
    Department of Defense DM160146Sep 30, 2017 - Sep 29, 2019
    Role: Co-Investigator
    Platelets Modulate Vascular Stability: Assessing the Biological Properties and Function of Apheresis Platelets Stored at 22o C vs. 4o C
    Department of Defense DOD W81XWH-16-2-0035 (Log#BA150440).Sep 30, 2016 - Sep 29, 2019
    Role: PI
    Mesenchymal Stem Cells for the prevention of Acute Respiratory Distress Syndrome after Pulmonary Contusion and Hemorrhagic Shock
    Department of Defense LogNo.BA150560Sep 30, 2016 - Sep 29, 2019
    Role: Co Investigator
    The Vasculo-protective and anti-inflammatory effects of Kcentra
    CSL BehringJul 7, 2016 - Jun 30, 2018
    Role: PI
    Modulation of Pulmonary Vascular Permeability and Inflammation by Mesenchymal Stem Cells (MSCs) in Hemorrhagic Shock
    NIGMS R01GM111899Sep 1, 2015 - Aug 31, 2020
    Role: PI

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Matthay MA, Pati S, Lee JW. Mesenchymal Stem (Stromal) Cells: Biology and Preclinical Evidence for Therapeutic Potential for Organ Dysfunction following Trauma or Sepsis. Stem Cells. 2016 Nov 26. PMID: 27888550.
      View in: PubMed
    2. Baimukanova G, Miyazawa B, Potter DR, Gibb SL, Keating S, Danesh A, Beyer A, Dayter Y, Bruhn R, Muench MO, Cap AP, Norris PJ, Spinella P, Cohen M, Pati S. The effects of 22°C and 4°C storage of platelets on vascular endothelial integrity and function. Transfusion. 2016 Mar; 56 Suppl 1:S52-64. PMID: 27001362.
      View in: PubMed
    3. Baimukanova G, Miyazawa B, Potter DR, Muench MO, Bruhn R, Gibb SL, Spinella PC, Cap AP, Cohen MJ, Pati S. Platelets regulate vascular endothelial stability: assessing the storage lesion and donor variability of apheresis platelets. Transfusion. 2016 Mar; 56 Suppl 1:S65-75. PMID: 27001364.
      View in: PubMed
    4. Gibb SL, Zhao Y, Potter D, Hylin MJ, Bruhn R, Baimukanova G, Zhao J, Xue H, Abdel-Mohsen M, Pillai SK, Moore AN, Johnson EM, Cox CS, Dash PK, Pati S. TIMP3 Attenuates the Loss of Neural Stem Cells, Mature Neurons and Neurocognitive Dysfunction in Traumatic Brain Injury. Stem Cells. 2015 Dec; 33(12):3530-44. PMID: 26299440.
      View in: PubMed
    5. Spinella PC, Frazier E, Pidcoke HF, Dietzen DJ, Pati S, Gorkun O, Aden JK, Norris PJ, Cap AP. All plasma products are not created equal: Characterizing differences between plasma products. J Trauma Acute Care Surg. 2015 Jun; 78(6 Suppl 1):S18-25. PMID: 26002258.
      View in: PubMed
    6. Potter DR, Baimukanova G, Keating SM, Deng X, Chu JA, Gibb SL, Peng Z, Muench MO, Fomin ME, Spinella PC, Kozar R, Pati S. Fresh frozen plasma and spray-dried plasma mitigate pulmonary vascular permeability and inflammation in hemorrhagic shock. J Trauma Acute Care Surg. 2015 Jun; 78(6 Suppl 1):S7-S17. PMID: 26002267.
      View in: PubMed
    7. Rahbar E, Cardenas JC, Baimukanova G, Usadi B, Bruhn R, Pati S, Ostrowski SR, Johansson PI, Holcomb JB, Wade CE. Endothelial glycocalyx shedding and vascular permeability in severely injured trauma patients. J Transl Med. 2015; 13:117. PMID: 25889764; PMCID: PMC4397670.
    8. Kornblith LZ, Howard BM, Cheung CK, Dayter Y, Pandey S, Busch MP, Pati S, Callcut RA, Vilardi RF, Redick BJ, Nelson MF, Cohen MJ. The whole is greater than the sum of its parts: hemostatic profiles of whole blood variants. J Trauma Acute Care Surg. 2014 Dec; 77(6):818-27. PMID: 25051379.
      View in: PubMed
    9. Cao Y, Dua A, Matijevic N, Wang YW, Pati S, Wade CE, Ko TC, Holcomb JB. Never-frozen liquid plasma blocks endothelial permeability as effectively as thawed fresh frozen plasma. J Trauma Acute Care Surg. 2014 Jul; 77(1):28-33; discussion 33. PMID: 24977751.
      View in: PubMed
    10. McKenna D, Matthay MA, Pati S. Correspondence to: soliciting strategies for developing cell-based reference materials to advance mesenchymal stem/stromal cell research and clinical translation. Stem Cells Dev. 2014 Aug 1; 23(15):1717-8. PMID: 24749526.
      View in: PubMed
    11. Jenkins DH, Rappold JF, Badloe JF, Berséus O, Blackbourne L, Brohi KH, Butler FK, Cap AP, Cohen MJ, Davenport R, DePasquale M, Doughty H, Glassberg E, Hervig T, Hooper TJ, Kozar R, Maegele M, Moore EE, Murdock A, Ness PM, Pati S, Rasmussen T, Sailliol A, Schreiber MA, Sunde GA, van de Watering LM, Ward KR, Weiskopf RB, White NJ, Strandenes G, Spinella PC. Trauma hemostasis and oxygenation research position paper on remote damage control resuscitation: definitions, current practice, and knowledge gaps. Shock. 2014 May; 41 Suppl 1:3-12. PMID: 24430539; PMCID: PMC4309265.
    12. Wataha K, Menge T, Deng X, Shah A, Bode A, Holcomb JB, Potter D, Kozar R, Spinella PC, Pati S. Spray-dried plasma and fresh frozen plasma modulate permeability and inflammation in vitro in vascular endothelial cells. Transfusion. 2013 Jan; 53 Suppl 1:80S-90S. PMID: 23301978.
      View in: PubMed
    13. Zhao J, Pati S, Redell JB, Zhang M, Moore AN, Dash PK. Caffeic Acid phenethyl ester protects blood-brain barrier integrity and reduces contusion volume in rodent models of traumatic brain injury. J Neurotrauma. 2012 Apr 10; 29(6):1209-18. PMID: 22150135; PMCID: PMC3325550.
    14. Holcomb JB, Zarzabal LA, Michalek JE, Kozar RA, Spinella PC, Perkins JG, Matijevic N, Dong JF, Pati S, Wade CE, Holcomb JB, Wade CE, Cotton BA, Kozar RA, Brasel KJ, Vercruysse GA, MacLeod JB, Dutton RP, Hess JR, Duchesne JC, McSwain NE, Muskat PC, Johannigamn JA, Cryer HM, Tillou A, Cohen MJ, Pittet JF, Knudson P, DeMoya MA, Schreiber MA, Tieu BH, Brundage SI, Napolitano LM, Brunsvold ME, Sihler KC, Beilman GJ, Peitzman AB, Zenati MS, Sperry JL, Alarcon LH, Croce MA, Minei JP, Steward RM, Cohn SM, Michalek JE, Bulger EM, Nunez TC, Ivatury RR, Meredith JW, Miller PR, Pomper GJ, Marin B. Increased platelet:RBC ratios are associated with improved survival after massive transfusion. J Trauma. 2011 Aug; 71(2 Suppl 3):S318-28. PMID: 21814099.
      View in: PubMed
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