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Association of Complement Factors With Disability Progression in Primary Progressive Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2024 Jul; 11(4):e200270.
Lunemann JD, Hegen H, Villar LM, Rejdak K, Sao-Aviles A, Carbonell-Mirabent P, Sastre-Garriga J, Mongay-Ochoa N, Berek K, Martínez-Yélamos S, Pérez-Miralles F, Abdelhak A, Bachhuber F, Tumani H, Lycke JN, Rosenstein I, Alvarez-Lafuente R, Castillo-Trivino T, Otaegui D, Llufriu S, Blanco Y, Sánchez López AJ, Garcia Merino JA, Fissolo N, Gutierrez L, Villacieros-Álvarez J, Monreal E, Valls-Carbó A, Wiendl H, Montalban X, Comabella M. PMID: 38912898; PMCID: PMC11226316.
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PubMed Mentions: Fields:
Translation:
Humans
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Targeting complement C3a receptor resolves mitochondrial hyperfusion and subretinal microglial activation in progranulin-deficient frontotemporal dementia. bioRxiv. 2024 Jun 01.
Tan LX, Oertel FC, Cheng A, Cobigo Y, Keihani A, Bennett DJ, Abdelhak A, Montes SC, Chapman M, Chen RY, Cordano C, Ward ME, Casaletto K, Kramer JH, Rosen HJ, Boxer A, Miller BL, Green AJ, Elahi FM, Lakkaraju A. PMID: 38854134; PMCID: PMC11160746.
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An autoantibody signature predictive for multiple sclerosis. Nat Med. 2024 May; 30(5):1300-1308.
Zamecnik CR, Sowa GM, Abdelhak A, Dandekar R, Bair RD, Wade KJ, Bartley CM, Kizer K, Augusto DG, Tubati A, Gomez R, Fouassier C, Gerungan C, Caspar CM, Alexander J, Wapniarski AE, Loudermilk RP, Eggers EL, Zorn KC, Ananth K, Jabassini N, Mann SA, Ragan NR, Santaniello A, Henry RG, Baranzini SE, Zamvil SS, Sabatino JJ, Bove RM, Guo CY, Gelfand JM, Cuneo R, von Büdingen HC, Oksenberg JR, Cree BAC, Hollenbach JA, Green AJ, Hauser SL, Wallin MT, DeRisi JL, Wilson MR. PMID: 38641750.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Neurofilaments as biomarkers in neurological disorders - towards clinical application. Nat Rev Neurol. 2024 05; 20(5):269-287.
Khalil M, Teunissen CE, Lehmann S, Otto M, Piehl F, Ziemssen T, Bittner S, Sormani MP, Gattringer T, Abu-Rumeileh S, Thebault S, Abdelhak A, Green A, Benkert P, Kappos L, Comabella M, Tumani H, Freedman MS, Petzold A, Blennow K, Zetterberg H, Leppert D, Kuhle J. PMID: 38609644.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Serum biomarker levels predict disability progression in patients with primary progressive multiple sclerosis. J Neurol Neurosurg Psychiatry. 2024 Apr 12; 95(5):410-418.
Fissolo N, Benkert P, Sastre-Garriga J, Mongay-Ochoa N, Vilaseca-Jolonch A, Llufriu S, Blanco Y, Hegen H, Berek K, Perez-Miralles F, Rejdak K, Villar LM, Monreal E, Alvarez-Lafuente R, Soylu OK, Abdelhak A, Bachhuber F, Tumani H, Martínez-Yélamos S, Sánchez-López AJ, García-Merino A, Gutiérrez L, Castillo-Trivino T, Lycke J, Rosenstein I, Furlan R, Filippi M, Téllez N, Ramió-Torrentà L, Lünemann JD, Wiendl H, Eichau S, Khalil M, Kuhle J, Montalban X, Comabella M. PMID: 37940409.
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Translation:
Humans
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Synaptic injury in the inner plexiform layer of the retina is associated with progression in multiple sclerosis. Cell Rep Med. 2024 Apr 16; 5(4):101490.
Cordano C, Werneburg S, Abdelhak A, Bennett DJ, Beaudry-Richard A, Duncan GJ, Oertel FC, Boscardin WJ, Yiu HH, Jabassini N, Merritt L, Nocera S, Sin JH, Samana IP, Condor Montes SY, Ananth K, Bischof A, UCSF MS EPIC Team, Nourbakhsh B, Hauser SL, Cree BAC, Emery B, Schafer DP, Chan JR, Green AJ. PMID: 38574736; PMCID: PMC11031420.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Scientific commentary on: "Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer's disease and primary tauopathies". Acta Neuropathol. 2024 02 03; 147(1):30.
Oertel FC, Casillas D, Cobigo Y, Condor Montes S, Heuer HW, Chapman M, Beaudry-Richard A, Reinsberg H, Abdelhak A, Cordano C, Boeve BF, Dickerson BC, Grossman M, Huey E, Irwin DJ, Litvan I, Pantelyat A, Tartaglia MC, Vandevrede L, Boxer A, Green AJ. PMID: 38308717; PMCID: PMC10838223.
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Translation:
Humans
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Serum glial fibrillary acidic protein and disability progression in progressive multiple sclerosis. Ann Clin Transl Neurol. 2024 02; 11(2):477-485.
Abdelhak A, Antweiler K, Kowarik MC, Senel M, Havla J, Zettl UK, Kleiter I, Skripuletz T, Haarmann A, Stahmann A, Huss A, Gingele S, Krumbholz M, Benkert P, Kuhle J, Friede T, Ludolph AC, Ziemann U, Kümpfel T, Tumani H. PMID: 38111972; PMCID: PMC10863922.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Neurofilament Light Chain Elevation and Disability Progression in Multiple Sclerosis. JAMA Neurol. 2023 12 01; 80(12):1317-1325.
Abdelhak A, Benkert P, Schaedelin S, Boscardin WJ, Cordano C, Oechtering J, Ananth K, Granziera C, Melie-Garcia L, Montes SC, Beaudry-Richard A, Achtnichts L, Oertel FC, Lalive PH, Leppert D, Müller S, Henry RG, Pot C, Matthias A, Salmen A, Oksenberg JR, Disanto G, Zecca C, D'Souza M, Du Pasquier R, Bridel C, Gobbi C, Kappos L, Hauser SL, Cree BAC, Kuhle J, Green AJ, UCSF, MS EPIC, and the SMSC Study Teams. PMID: 37930670; PMCID: PMC10628837.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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Patient-reported outcome parameters and disability worsening in progressive multiple sclerosis. Mult Scler Relat Disord. 2024 Jan; 81:105139.
Abdelhak A, Antweiler K, Kowarik MC, Senel M, Havla J, Zettl UK, Kleiter I, Hoshi MM, Skripuletz T, Haarmann A, Stahmann A, Huss A, Gingele S, Krumbholz M, Selge C, Friede T, Ludolph AC, Overell J, Koendgen H, Clinch S, Wang Q, Ziemann U, Hauser SL, Kümpfel T, Green AJ, Tumani H. PMID: 38000130; PMCID: PMC10959125.
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Translation:
Humans
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Remyelination protects neurons from DLK-mediated neurodegeneration. bioRxiv. 2023 Oct 12.
Duncan GJ, Ingram SD, Emberley K, Hill J, Cordano C, Abdelhak A, McCane M, Jabassini N, Ananth K, Ferrara SJ, Stedelin B, Sivyer B, Aicher SA, Scanlan T, Watkins TA, Mishra A, Nelson J, Green AJ, Emery B. PMID: 37873342; PMCID: PMC10592610.
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Serum neurofilament light chain reference database for individual application in paediatric care: a retrospective modelling and validation study. Lancet Neurol. 2023 09; 22(9):826-833.
Abdelhak A, Petermeier F, Benkert P, Schädelin S, Oechtering J, Maleska Maceski A, Kabesch M, Geis T, Laub O, Leipold G, Gobbi C, Zecca C, Green A, Tumani H, Willemse E, Wiendl H, Granziera C, Kappos L, Leppert D, Waubant E, Wellmann S, Kuhle J. PMID: 37524100.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Editorial: CSF and blood biomarkers in COVID-19 and other neuroinfectious diseases. Front Neurol. 2023; 14:1239750.
Foschi M, Abu-Rumeileh S, Massa F, Cordano C, Abdelhak A. PMID: 37497014; PMCID: PMC10368364.
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Challenges and Opportunities for the Promising Biomarker Blood Neurofilament Light Chain. JAMA Neurol. 2023 06 01; 80(6):542-543.
Abdelhak A, Kuhle J, Green AJ. PMID: 37010852.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Prognostic performance of blood neurofilament light chain protein in hospitalized COVID-19 patients without major central nervous system manifestations: an individual participant data meta-analysis. J Neurol. 2023 Jul; 270(7):3315-3328.
Abdelhak A, Barba L, Romoli M, Benkert P, Conversi F, D'Anna L, Masvekar RR, Bielekova B, Prudencio M, Petrucelli L, Meschia JF, Erben Y, Furlan R, De Lorenzo R, Mandelli A, Sutter R, Hert L, Epple V, Marastoni D, Sellner J, Steinacker P, Aamodt AH, Heggelund L, Dyrhol-Riise AM, Virhammar J, Fällmar D, Rostami E, Kumlien E, Blennow K, Zetterberg H, Tumani H, Sacco S, Green AJ, Otto M, Kuhle J, Ornello R, Foschi M, Abu-Rumeileh S. PMID: 37184659; PMCID: PMC10183689.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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A Predictive Autoantibody Signature in Multiple Sclerosis. medRxiv. 2023 May 15.
Zamecnik CR, Sowa GM, Abdelhak A, Dandekar R, Bair RD, Wade KJ, Bartley CM, Tubati A, Gomez R, Fouassier C, Gerungan C, Alexander J, Wapniarski AE, Loudermilk RP, Eggers EL, Zorn KC, Ananth K, Jabassini N, Mann SA, Ragan NR, Santaniello A, Henry RG, Baranzini SE, Zamvil SS, Bove RM, Guo CY, Gelfand JM, Cuneo R, von Büdingen HC, Oksenberg JR, Cree BA, Hollenbach JA, Green AJ, Hauser SL, Wallin MT, DeRisi JL, Wilson MR. PMID: 37205595; PMCID: PMC10187343.
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Visually Evoked Potential as Prognostic Biomarker for Neuroaxonal Damage in Multiple Sclerosis From a Multicenter Longitudinal Cohort. Neurol Neuroimmunol Neuroinflamm. 2023 05; 10(3).
Oertel FC, Krämer J, Motamedi S, Keihani A, Zimmermann HG, Dimitriou NG, Condor-Montes S, Bereuter C, Cordano C, Abdelhak A, Trip A, Aktas O, Meuth SG, Wiendl H, Ruprecht K, Bellmann-Strobl J, Paul F, Petzold A, Brandt AU, Albrecht P, Green AJ. PMID: 36878713; PMCID: PMC10026703.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Serum Glial Fibrillary Acidic Protein Compared With Neurofilament Light Chain as a Biomarker for Disease Progression in Multiple Sclerosis. JAMA Neurol. 2023 03 01; 80(3):287-297.
Meier S, Willemse EAJ, Schaedelin S, Oechtering J, Lorscheider J, Melie-Garcia L, Cagol A, Barakovic M, Galbusera R, Subramaniam S, Barro C, Abdelhak A, Thebault S, Achtnichts L, Lalive P, Müller S, Pot C, Salmen A, Disanto G, Zecca C, D'Souza M, Orleth A, Khalil M, Buchmann A, Du Pasquier R, Yaldizli Ö, Derfuss T, Berger K, Hermesdorf M, Wiendl H, Piehl F, Battaglini M, Fischer U, Kappos L, Gobbi C, Granziera C, Bridel C, Leppert D, Maleska Maceski A, Benkert P, Kuhle J. PMID: 36745446; PMCID: PMC10011932.
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PubMed Mentions:
26 Fields:
Translation:
HumansCells
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The multifaceted role of neurofilament light chain protein in non-primary neurological diseases. Brain. 2023 02 13; 146(2):421-437.
Abu-Rumeileh S, Abdelhak A, Foschi M, D'Anna L, Russo M, Steinacker P, Kuhle J, Tumani H, Blennow K, Otto M. PMID: 36083979; PMCID: PMC9494370.
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PubMed Mentions:
34 Fields:
Translation:
HumansCells
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Serum Neurofilament Light Chain and Glial Fibrillary Acidic Protein as Biomarkers in Primary Progressive Multiple Sclerosis and Hereditary Spastic Paraplegia Type 4. Int J Mol Sci. 2022 Nov 03; 23(21).
Kessler C, Ruschil C, Abdelhak A, Wilke C, Maleska A, Kuhle J, Krumbholz M, Kowarik MC, Schüle R. PMID: 36362248; PMCID: PMC9657281.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Differences in Age-related Retinal and Cortical Atrophy Rates in Multiple Sclerosis. Neurology. 2022 10 11; 99(15):e1685-e1693.
Cordano C, Nourbakhsh B, Yiu HH, Papinutto N, Caverzasi E, Abdelhak A, Oertel FC, Beaudry-Richard A, Santaniello A, Sacco S, Bennett DJ, Gomez A, Sigurdson CJ, Hauser SL, Magliozzi R, Cree BAC, Henry RG, Green AJ. PMID: 36038272; PMCID: PMC9559941.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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Association of Serum GFAP with Functional and Neurocognitive Outcome in Sporadic Small Vessel Disease. Biomedicines. 2022 Aug 02; 10(8).
Huss A, Abdelhak A, Mayer B, Tumani H, Müller HP, Althaus K, Kassubek J, Otto M, Ludolph AC, Yilmazer-Hanke D, Neugebauer H. PMID: 36009416; PMCID: PMC9405121.
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PubMed Mentions:
8
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Retinal arteriolar parameters as a surrogate marker of intracranial vascular pathology. Alzheimers Dement (Amst). 2022; 14(1):e12338.
Abdelhak A, Solomon I, Montes SC, Saias A, Cordano C, Asken B, Fonseca C, Oertel FC, Arfanakis K, Staffaroni AM, Kramer JH, Geschwind M, Miller BL, Elahi FM, Green AJ. PMID: 35814617; PMCID: PMC9257197.
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PubMed Mentions:
2
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Plasma neurofilament light chain levels suggest neuroaxonal stability following therapeutic remyelination in people with multiple sclerosis. J Neurol Neurosurg Psychiatry. 2022 Jun 16.
Abdelhak A, Cordano C, Boscardin WJ, Caverzasi E, Kuhle J, Chan B, Gelfand JM, Yiu HH, Oertel FC, Beaudry-Richard A, Condor Montes S, Oksenberg JR, Lario Lago A, Boxer A, Rojas-Martinez JC, Elahi FM, Chan JR, Green AJ. PMID: 35710320; PMCID: PMC9984688.
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PubMed Mentions:
6 Fields:
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Reply to "Interpretation of Longitudinal Changes of the Inner Nuclear Layer in MS". Ann Neurol. 2022 07; 92(1):156.
Cordano C, Yiu HH, Abdelhak A, Beaudry-Richard A, Oertel FC, Green AJ. PMID: 35403744.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Blood GFAP as an emerging biomarker in brain and spinal cord disorders. Nat Rev Neurol. 2022 03; 18(3):158-172.
Abdelhak A, Foschi M, Abu-Rumeileh S, Yue JK, D'Anna L, Huss A, Oeckl P, Ludolph AC, Kuhle J, Petzold A, Manley GT, Green AJ, Otto M, Tumani H. PMID: 35115728.
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PubMed Mentions:
141 Fields:
Translation:
HumansCells
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Diagnostic and Prognostic Blood Biomarkers in Transient Ischemic Attack and Minor Ischemic Stroke: An Up-To-Date Narrative Review. J Stroke Cerebrovasc Dis. 2022 Mar; 31(3):106292.
Foschi M, Padroni M, Abu-Rumeileh S, Abdelhak A, Russo M, D'Anna L, Guarino M. PMID: 35026496.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Ongoing challenges in unravelling the association between COVID-19 and Guillain-Barré syndrome. Brain. 2021 06 22; 144(5):e44.
Foschi M, D'Anna L, Abdelhak A, Mayer B, Tumani H, Otto M, Abu-Rumeileh S. PMID: 33822000; PMCID: PMC8083498.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Cerebrospinal Fluid Biomarkers in Relation to MRZ Reaction Status in Primary Progressive Multiple Sclerosis. Cells. 2020 11 25; 9(12).
Robinson T, Abdelhak A, Bose T, Meinl E, Otto M, Zettl UK, Dersch R, Tumani H, Rauer S, Huss A. PMID: 33255854; PMCID: PMC7761295.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Longitudinal Serum Neurofilament Levels of Multiple Sclerosis Patients Before and After Treatment with First-Line Immunomodulatory Therapies. Biomedicines. 2020 Aug 28; 8(9).
Huss A, Senel M, Abdelhak A, Mayer B, Kassubek J, Ludolph AC, Otto M, Tumani H. PMID: 32872144; PMCID: PMC7555392.
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PubMed Mentions:
10
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Guillain-Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases. J Neurol. 2021 Apr; 268(4):1133-1170.
Abu-Rumeileh S, Abdelhak A, Foschi M, Tumani H, Otto M. PMID: 32840686; PMCID: PMC7445716.
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PubMed Mentions:
195 Fields:
Translation:
HumansCells
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Differential effects of disease modifying drugs on peripheral blood B cell subsets: A cross sectional study in multiple sclerosis patients treated with interferon-β, glatiramer acetate, dimethyl fumarate, fingolimod or natalizumab. PLoS One. 2020; 15(7):e0235449.
Kemmerer CL, Pernpeintner V, Ruschil C, Abdelhak A, Scholl M, Ziemann U, Krumbholz M, Hemmer B, Kowarik MC. PMID: 32716916; PMCID: PMC7384624.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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A Score Based on NfL and Glial Markers May Differentiate Between Relapsing-Remitting and Progressive MS Course. Front Neurol. 2020; 11:608.
Huss A, Otto M, Senel M, Ludolph AC, Abdelhak A, Tumani H. PMID: 32765393; PMCID: PMC7378743.
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PubMed Mentions:
17
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Explorative study of emerging blood biomarkers in progressive multiple sclerosis (EmBioProMS): Design of a prospective observational multicentre pilot study. Contemp Clin Trials Commun. 2020 Jun; 18:100574.
Abdelhak A, Huss A, Stahmann A, Senel M, Krumbholz M, Kowarik MC, Havla J, Kümpfel T, Kleiter I, Wüstinger I, Zettl UK, Schwartz M, Roesler R, Friede T, Ludolph AC, Ziemann U, Tumani H. PMID: 32478196; PMCID: PMC7251538.
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PubMed Mentions:
2
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Optical coherence tomography-based assessment of retinal vascular pathology in cerebral small vessel disease. Neurol Res Pract. 2020; 2:13.
Abdelhak A, Huss A, Brück A, Sebert U, Mayer B, Müller HP, Tumani H, Otto M, Yilmazer-Hanke D, Ludolph AC, Kassubek J, Pinkhardt E, Neugebauer H. PMID: 33324919; PMCID: PMC7650138.
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PubMed Mentions:
10
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Author Correction: Serum GFAP as a biomarker for disease severity in multiple sclerosis. Sci Rep. 2019 Jun 05; 9(1):8433.
Abdelhak A, Huss A, Kassubek J, Tumani H, Otto M. PMID: 31164658; PMCID: PMC6548773.
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PubMed Mentions:
1 Fields:
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Glial Activation Markers in CSF and Serum From Patients With Primary Progressive Multiple Sclerosis: Potential of Serum GFAP as Disease Severity Marker? Front Neurol. 2019; 10:280.
Abdelhak A, Hottenrott T, Morenas-Rodríguez E, Suárez-Calvet M, Zettl UK, Haass C, Meuth SG, Rauer S, Otto M, Tumani H, Huss A. PMID: 30972011; PMCID: PMC6443875.
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PubMed Mentions:
48
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Serum GFAP as a biomarker for disease severity in multiple sclerosis. Sci Rep. 2018 10 04; 8(1):14798.
Abdelhak A, Huss A, Kassubek J, Tumani H, Otto M. PMID: 30287870; PMCID: PMC6172254.
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PubMed Mentions:
94 Fields:
Translation:
Humans
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Intrathecal immunoglobulin M production: A promising high-risk marker in clinically isolated syndrome patients. Ann Neurol. 2018 05; 83(5):1032-1036.
Huss A, Abdelhak A, Halbgebauer S, Mayer B, Senel M, Otto M, Tumani H. PMID: 29665046.
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PubMed Mentions:
12 Fields:
Translation:
Humans
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MOG-IgG in primary and secondary chronic progressive multiple sclerosis: a multicenter study of 200 patients and review of the literature. J Neuroinflammation. 2018 Mar 19; 15(1):88.
Jarius S, Ruprecht K, Stellmann JP, Huss A, Ayzenberg I, Willing A, Trebst C, Pawlitzki M, Abdelhak A, Grüter T, Leypoldt F, Haas J, Kleiter I, Tumani H, Fechner K, Reindl M, Paul F, Wildemann B. PMID: 29554927; PMCID: PMC5859439.
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PubMed Mentions:
30 Fields:
Translation:
HumansCells
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In vivo assessment of retinal vessel pathology in amyotrophic lateral sclerosis. J Neurol. 2018 Apr; 265(4):949-953.
Abdelhak A, Hübers A, Böhm K, Ludolph AC, Kassubek J, Pinkhardt EH. PMID: 29464376.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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CSF profile in primary progressive multiple sclerosis: Re-exploring the basics. PLoS One. 2017; 12(8):e0182647.
Abdelhak A, Hottenrott T, Mayer C, Hintereder G, Zettl UK, Stich O, Tumani H. PMID: 28797088; PMCID: PMC5552348.
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PubMed Mentions:
12 Fields:
Translation:
Humans
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Primary Progressive Multiple Sclerosis: Putting Together the Puzzle. Front Neurol. 2017; 8:234.
Abdelhak A, Weber MS, Tumani H. PMID: 28620346; PMCID: PMC5449443.
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PubMed Mentions:
22
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Brain-Specific Cytoskeletal Damage Markers in Cerebrospinal Fluid: Is There a Common Pattern between Amyotrophic Lateral Sclerosis and Primary Progressive Multiple Sclerosis? Int J Mol Sci. 2015 Jul 31; 16(8):17565-88.
Abdelhak A, Junker A, Brettschneider J, Kassubek J, Ludolph AC, Otto M, Tumani H. PMID: 26263977; PMCID: PMC4581209.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansCells