Karin Gaensler, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, MSB
San Francisco CA 94117
Phone415-476-5259
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPost-Doc Fellow/Scholar1988 Medicine (Cancer Research Institute)
    University of California, San Francisco Residency
    Harvard UniversityM.D.1981School of Medicine

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Efficacy and safety of novel CD80 IL15 IL15Ra expressing autologous AML vaccines
    NIH R21CA177284Aug 6, 2013 - Jul 31, 2015
    Role: Principal Investigator
    Lentivirus-based positive/negative selection in minimally ablative transplants
    NIH R01HL107974Dec 1, 2011 - Nov 30, 2015
    Role: Principal Investigator
    Neonatal Chemoselection Following Ex Vivo Gene Transfer For Hereditary Disorders
    NIH R01HL082665May 12, 2008 - Apr 30, 2013
    Role: Principal Investigator
    Tolerance Induction by Neonatal Gene Delivery
    NIH R01DK072537Apr 15, 2006 - Apr 14, 2012
    Role: Principal Investigator
    In Vivo Stem Cell Selection in Neonatal Allo-Transplants
    NIH R21DK069430Sep 20, 2005 - Aug 31, 2008
    Role: Principal Investigator
    SEQUENTIAL PRE AND POSTNATAL GENE THERAPY OF HEMOPHILIA
    NIH R01HL062389Sep 1, 1999 - Aug 31, 2004
    Role: Principal Investigator
    GENE THERAPY STRATEGIES FOR SICKLE CELL DISEASE
    NIH P01HL053762Sep 30, 1994 - Aug 31, 2007
    Role: Co-Investigator
    ANALYSIS OF B GLOBIN LOCUS REGULATION BY YAC TRANSFER
    NIH K11HL002711Mar 1, 1992 - Jul 31, 1997
    Role: Principal Investigator
    NORTHERN CALIFORNIA COMPREHENSIVE SICKLE CELL CENTER
    NIH P60HL020985Apr 1, 1978 - Mar 31, 2004
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Patterns and Predictors of Functional Decline after Allogeneic Hematopoietic Cell Transplantation in Older Adults. Transplant Cell Ther. 2022 Mar 03. Huang LW, Sheng Y, Andreadis C, Logan AC, Mannis GN, Smith CC, Gaensler KML, Martin TG, Damon LE, Huang CY, Olin RL. PMID: 35247612.
      View in: PubMed   Mentions:
    2. Inhibition of MET Signaling with Ficlatuzumab in Combination with Chemotherapy in Refractory AML: Clinical Outcomes and High-Dimensional Analysis. Blood Cancer Discov. 2021 09; 2(5):434-449. Wang VE, Blaser BW, Patel RK, Behbehani GK, Rao AA, Durbin-Johnson B, Jiang T, Logan AC, Settles M, Mannis GN, Olin R, Damon LE, Martin TG, Sayre PH, Gaensler KM, McMahon E, Flanders M, Weinberg V, Ye CJ, Carbone DP, Munster PN, Fragiadakis GK, McCormick F, Andreadis C. PMID: 34514432; PMCID: PMC8425277.
      View in: PubMed   Mentions:
    3. Functional Status as Measured by Geriatric Assessment Predicts Inferior Survival in Older Allogeneic Hematopoietic Cell Transplantation Recipients. Biol Blood Marrow Transplant. 2020 01; 26(1):189-196. Huang LW, Sheng Y, Andreadis C, Logan AC, Mannis GN, Smith CC, Gaensler KML, Martin TG, Damon LE, Steinman MA, Huang CY, Olin RL. PMID: 31493541; PMCID: PMC6942208.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    4. Histone Deacetylase Inhibition with Panobinostat Combined with Intensive Induction Chemotherapy in Older Patients with Acute Myeloid Leukemia: Phase I Study Results. Clin Cancer Res. 2019 08 15; 25(16):4917-4923. Wieduwilt MJ, Pawlowska N, Thomas S, Olin R, Logan AC, Damon LE, Martin T, Kang M, Sayre PH, Boyer W, Gaensler KML, Anderson K, Munster PN, Andreadis C. PMID: 31152020.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCellsCTClinical Trials
    5. IL-15/IL-15Rα/CD80-expressing AML cell vaccines eradicate minimal residual disease in leukemic mice. Blood Adv. 2018 11 27; 2(22):3177-3192. Shi Y, Dincheva-Vogel L, Ayemoba CE, Fung JP, Bergamaschi C, Pavlakis GN, Farzaneh F, Gaensler KML. PMID: 30482760; PMCID: PMC6258921.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    6. Myelodysplastic Syndromes, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2017 01; 15(1):60-87. Greenberg PL, Stone RM, Al-Kali A, Barta SK, Bejar R, Bennett JM, Carraway H, De Castro CM, Deeg HJ, DeZern AE, Fathi AT, Frankfurt O, Gaensler K, Garcia-Manero G, Griffiths EA, Head D, Horsfall R, Johnson RA, Juckett M, Klimek VM, Komrokji R, Kujawski LA, Maness LJ, O'Donnell MR, Pollyea DA, Shami PJ, Stein BL, Walker AR, Westervelt P, Zeidan A, Shead DA, Smith C. PMID: 28040720.
      View in: PubMed   Mentions: 78     Fields:    Translation:Humans
    7. Quantification of Acute Lymphoblastic Leukemia Clonotypes in Leukapheresed Peripheral Blood Progenitor Cells Predicts Relapse Risk after Autologous Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2016 06; 22(6):1030-1036. Mannis GN, Martin TG, Damon LE, Andreadis C, Olin RL, Kong KA, Faham M, Hwang J, Ai WZ, Gaensler KML, Sayre PH, Wolf JL, Logan AC. PMID: 26899561.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    8. Long-term outcomes of patients with intermediate-risk acute myeloid leukemia treated with autologous hematopoietic cell transplant in first complete remission. Leuk Lymphoma. 2016 07; 57(7):1560-6. Mannis GN, Martin TG, Damon LE, Logan AC, Olin RL, Flanders MD, Ai WZ, Gaensler KM, Kaplan LD, Sayre PH, Smith CC, Wolf JL, Andreadis C. PMID: 26490487.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. Nitric Oxide-cGMP Signaling Stimulates Erythropoiesis through Multiple Lineage-Specific Transcription Factors: Clinical Implications and a Novel Target for Erythropoiesis. PLoS One. 2016; 11(1):e0144561. Ikuta T, Sellak H, Odo N, Adekile AD, Gaensler KM. PMID: 26727002; PMCID: PMC4699757.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    10. An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo. Nano Lett. 2015 Dec 09; 15(12):8099-107. Li B, Luo X, Deng B, Wang J, McComb DW, Shi Y, Gaensler KM, Tan X, Dunn AL, Kerlin BA, Dong Y. PMID: 26529392; PMCID: PMC4869688.
      View in: PubMed   Mentions: 41  Translation:Humans
    11. The combined molecular adjuvant CASAC enhances the CD8+ T cell response to a tumor-associated self-antigen in aged, immunosenescent mice. Immun Ageing. 2015; 12:6. Tye GJ, Ioannou K, Amofah E, Quartey-Papafio R, Westrop SJ, Krishnamurthy P, Noble A, Harrison PM, Gaensler KML, Barber LD, Farzaneh F. PMID: 26157468; PMCID: PMC4495856.
      View in: PubMed   Mentions: 1  
    12. Myelodysplastic syndromes, version 2.2015. J Natl Compr Canc Netw. 2015 Mar; 13(3):261-72. Greenberg PL, Stone RM, Bejar R, Bennett JM, Bloomfield CD, Borate U, De Castro CM, Deeg HJ, DeZern AE, Fathi AT, Frankfurt O, Gaensler K, Garcia-Manero G, Griffiths EA, Head D, Klimek V, Komrokji R, Kujawski LA, Maness LJ, O'Donnell MR, Pollyea DA, Scott B, Shami PJ, Stein BL, Westervelt P, Wheeler B, Shead DA, Smith C, National comprehensive cancer network. PMID: 25736003; PMCID: PMC4696005.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    13. A phase I study of targeted, dose-escalated intravenous busulfan in combination with etoposide as myeloablative therapy for autologous stem cell transplantation in acute myeloid leukemia. Clin Lymphoma Myeloma Leuk. 2015 Jun; 15(6):377-83. Mannis GN, Andreadis C, Logan AC, Damon LE, Benet LZ, Ai WZ, Gaensler KM, Kaplan LD, Koplowicz YB, Linker CA, Olin RL, Sayre PH, Smith CC, Sudhindra A, Venstrom JM, Wolf JL, Martin TG. PMID: 25776193.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    14. Promoterless gene targeting without nucleases ameliorates haemophilia B in mice. Nature. 2015 Jan 15; 517(7534):360-4. Barzel A, Paulk NK, Shi Y, Huang Y, Chu K, Zhang F, Valdmanis PN, Spector LP, Porteus MH, Gaensler KM, Kay MA. PMID: 25363772; PMCID: PMC4297598.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    15. Delayed hematopoietic recovery after auto-SCT in patients receiving arsenic trioxide-based therapy for acute promyelocytic leukemia: a multi-center analysis. Bone Marrow Transplant. 2015 Jan; 50(1):40-4. Mannis GN, Logan AC, Leavitt AD, Yanada M, Hwang J, Olin RL, Damon LE, Andreadis C, Ai WZ, Gaensler KM, Greene CC, Gupta NK, Kaplan LD, Mahindra A, Miyazaki Y, Naoe T, Ohtake S, Sayre PH, Smith CC, Venstrom JM, Wolf JL, Caballero L, Emi N, Martin TG. PMID: 25243620.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    16. Hematopoietic cell transplantation comorbidity index (HCT-CI) is predictive of adverse events and overall survival in older allogeneic transplant recipients. J Geriatr Oncol. 2014 Jul; 5(3):238-44. Keller JW, Andreadis C, Damon LE, Kaplan LD, Martin TG, Wolf JL, Ai WZ, Venstrom JM, Smith CC, Gaensler KM, Hwang J, Olin RL. PMID: 24894413.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    17. Role of antigen-specific regulatory CD4+CD25+ T cells in tolerance induction after neonatal IP administration of AAV-hF.IX. Gene Ther. 2013 Oct; 20(10):987-96. Shi Y, Falahati R, Zhang J, Flebbe-Rehwaldt L, Gaensler KM. PMID: 23759700; PMCID: PMC3795474.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    18. Early Chk1 phosphorylation is driven by temozolomide-induced, DNA double strand break- and mismatch repair-independent DNA damage. PLoS One. 2013; 8(5):e62351. Ito M, Ohba S, Gaensler K, Ronen SM, Mukherjee J, Pieper RO. PMID: 23667469; PMCID: PMC3646831.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    19. Chemoselection of allogeneic HSC after murine neonatal transplantation without myeloablation or post-transplant immunosuppression. Mol Ther. 2012 Nov; 20(11):2180-9. Falahati R, Zhang J, Flebbe-Rehwaldt L, Shi Y, Gerson SL, Gaensler KM. PMID: 22871662; PMCID: PMC3498795.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    20. MicroRNA-181a* Targets Nanog in a Subpopulation of CD34(+) Cells Isolated From Peripheral Blood. Mol Ther Nucleic Acids. 2012 Aug 07; 1:e34. Mintz PJ, Sætrom P, Reebye V, Lundbæk MB, Lao K, Rossi JJ, Gaensler KM, Kasahara N, Nicholls JP, Jensen S, Haoudi A, Emara MM, Gordon MY, Habib NA. PMID: 23344176; PMCID: PMC3437805.
      View in: PubMed   Mentions: 7  
    21. Transcription factors KLF1 and KLF2 positively regulate embryonic and fetal beta-globin genes through direct promoter binding. J Biol Chem. 2011 Jul 15; 286(28):24819-27. Alhashem YN, Vinjamur DS, Basu M, Klingmüller U, Gaensler KM, Lloyd JA. PMID: 21610079; PMCID: PMC3137057.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    22. Suppression of HLA expression by lentivirus-mediated gene transfer of siRNA cassettes and in vivo chemoselection to enhance hematopoietic stem cell transplantation. Immunol Res. 2009; 44(1-3):112-26. Hacke K, Falahati R, Flebbe-Rehwaldt L, Kasahara N, Gaensler KM. PMID: 19048410; PMCID: PMC2938774.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    23. Impact of intensive PBSC mobilization therapy on outcomes following auto-SCT for non-Hodgkin's lymphoma. Bone Marrow Transplant. 2008 Nov; 42(10):649-57. Damon L, Damon LE, Gaensler K, Kaplan L, Martin T, Rubenstein J, Linker C. PMID: 18679366; PMCID: PMC4372391.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    24. A mechanism for Ikaros regulation of human globin gene switching. Br J Haematol. 2008 May; 141(3):398-406. Keys JR, Tallack MR, Zhan Y, Papathanasiou P, Goodnow CC, Gaensler KM, Crossley M, Dekker J, Perkins AC. PMID: 18318763.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    25. Methyl binding domain protein 2 mediates gamma-globin gene silencing in adult human betaYAC transgenic mice. Proc Natl Acad Sci U S A. 2006 Apr 25; 103(17):6617-22. Rupon JW, Wang SZ, Gaensler K, Lloyd J, Ginder GD. PMID: 16608912; PMCID: PMC1458932.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    26. KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic beta-like globin genes in vivo. Blood. 2005 Oct 01; 106(7):2566-71. Basu P, Morris PE, Haar JL, Wani MA, Lingrel JB, Gaensler KM, Lloyd JA. PMID: 15947087; PMCID: PMC1895257.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    27. Comparison of gene expression after intraperitoneal delivery of AAV2 or AAV5 in utero. Mol Ther. 2003 Jul; 8(1):90-8. Lipshutz GS, Titre D, Brindle M, Bisconte AR, Contag CH, Gaensler KM. PMID: 12842432.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    28. Sequences in the (A)gamma-delta intergenic region are not required for stage-specific regulation of the human beta-globin gene locus. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3374-9. Gaensler KM, Zhang Z, Lin C, Yang S, Hardt K, Flebbe-Rehwaldt L. PMID: 12629213; PMCID: PMC152300.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    29. In utero delivery of adeno-associated viral vectors: intraperitoneal gene transfer produces long-term expression. Mol Ther. 2001 Mar; 3(3):284-92. Lipshutz GS, Gruber CA, Hardy J, Contag CH, Gaensler KM. PMID: 11273769.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    30. Reexpression following readministration of an adenoviral vector in adult mice after initial in utero adenoviral administration. Mol Ther. 2000 Oct; 2(4):374-80. Lipshutz GS, Flebbe-Rehwaldt L, Gaensler KM. PMID: 11020353.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    31. Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin. Nature. 2000 Jul 06; 406(6791):82-6. May C, Rivella S, Callegari J, Heller G, Gaensler KM, Luzzatto L, Sadelain M. PMID: 10894546.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansAnimalsCells
    32. Fetal gene transfer by transuterine injection of cationic liposome-DNA complexes. Nat Biotechnol. 1999 Dec; 17(12):1188-92. Gaensler KM, Tu G, Bruch S, Liggitt D, Lipshutz GS, Metkus A, Harrison M, Heath TD, Debs RJ. PMID: 10585716.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    33. Short-term correction of factor VIII deficiency in a murine model of hemophilia A after delivery of adenovirus murine factor VIII in utero. Proc Natl Acad Sci U S A. 1999 Nov 09; 96(23):13324-9. Lipshutz GS, Sarkar R, Flebbe-Rehwaldt L, Kazazian H, Gaensler KM. PMID: 10557319; PMCID: PMC23946.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    34. Adenovirus-mediated gene transfer to the peritoneum and hepatic parenchyma of fetal mice in utero. Surgery. 1999 Aug; 126(2):171-7. Lipshutz GS, Flebbe-Rehwaldt L, Gaensler KM. PMID: 10455880.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    35. Adenovirus-mediated gene transfer in the midgestation fetal mouse. J Surg Res. 1999 Jun 15; 84(2):150-6. Lipshutz GS, Flebbe-Rehwaldt L, Gaensler KM. PMID: 10357912.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    36. Transgenic knockout mice exclusively expressing human hemoglobin S after transfer of a 240-kb betas-globin yeast artificial chromosome: A mouse model of sickle cell anemia. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14886-90. Chang JC, Lu R, Lin C, Xu SM, Kan YW, Porcu S, Carlson E, Kitamura M, Yang S, Flebbe-Rehwaldt L, Gaensler KM. PMID: 9843985; PMCID: PMC24545.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    37. The human beta globin locus introduced by YAC transfer exhibits a specific and reproducible pattern of developmental regulation in transgenic mice. Blood. 1997 Dec 01; 90(11):4602-9. Porcu S, Kitamura M, Witkowska E, Zhang Z, Mutero A, Lin C, Chang J, Gaensler KM. PMID: 9373272.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    38. Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF. Proc Natl Acad Sci U S A. 1996 Oct 29; 93(22):12267-71. Perkins AC, Gaensler KM, Orkin SH. PMID: 8901569; PMCID: PMC37979.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    39. Cationic liposome-mediated intravenous gene delivery. J Biol Chem. 1995 Oct 20; 270(42):24864-70. Liu Y, Liggitt D, Zhong W, Tu G, Gaensler K, Debs R. PMID: 7559609.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    40. Germ-line transmission and developmental regulation of a 150-kb yeast artificial chromosome containing the human beta-globin locus in transgenic mice. Proc Natl Acad Sci U S A. 1993 Dec 01; 90(23):11381-5. Gaensler KM, Kitamura M, Kan YW. PMID: 8248258; PMCID: PMC47986.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    41. Aerosol gene delivery in vivo. Proc Natl Acad Sci U S A. 1992 Dec 01; 89(23):11277-81. Stribling R, Brunette E, Liggitt D, Gaensler K, Debs R. PMID: 1454808; PMCID: PMC50533.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    42. Prolonged transgene expression in rodent lung cells. Am J Respir Cell Mol Biol. 1992 Oct; 7(4):406-13. Debs R, Pian M, Gaensler K, Clements J, Friend DS, Dobbs L. PMID: 1327013.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    43. Physical mapping of yeast artificial chromosomes containing sequences from the human beta-globin gene region. Genomics. 1991 Aug; 10(4):976-84. Gaensler KM, Burmeister M, Brownstein BH, Taillon-Miller P, Myers RM. PMID: 1916829.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    44. Genetic and biochemical analysis of the mouse beta-major globin promoter. Prog Clin Biol Res. 1989; 316A:117-27. Myers RM, Cowie A, Stuve L, Hartzog G, Gaensler K. PMID: 2594802.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
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