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Karin Gaensler, MD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentMedicine
Address505 Parnassus Avenue
San Francisco CA 94117
Phone415-502-4390
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPost-Doc Fellow/Scholar1988 Medicine (Cancer Research Institute)
    University of California, San Francisco Residency
    Harvard UniversityM.D.1981School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Efficacy and safety of novel CD80 IL15 IL15Ra expressing autologous AML vaccines
    NIH R21CA177284Aug 6, 2013 - Jul 31, 2015
    Role: Principal Investigator
    Lentivirus-based positive/negative selection in minimally ablative transplants
    NIH R01HL107974Dec 1, 2011 - Nov 30, 2015
    Role: Principal Investigator
    Neonatal Chemoselection Following Ex Vivo Gene Transfer For Hereditary Disorders
    NIH R01HL082665May 12, 2008 - Apr 30, 2013
    Role: Principal Investigator
    Tolerance Induction by Neonatal Gene Delivery
    NIH R01DK072537Apr 15, 2006 - Apr 14, 2012
    Role: Principal Investigator
    In Vivo Stem Cell Selection in Neonatal Allo-Transplants
    NIH R21DK069430Sep 20, 2005 - Aug 31, 2008
    Role: Principal Investigator
    SEQUENTIAL PRE AND POSTNATAL GENE THERAPY OF HEMOPHILIA
    NIH R01HL062389Sep 1, 1999 - Aug 31, 2004
    Role: Principal Investigator
    GENE THERAPY STRATEGIES FOR SICKLE CELL DISEASE
    NIH/NHLBI P01HL053762Sep 30, 1994 - Aug 31, 2007
    Role: Co-Investigator
    ANALYSIS OF B GLOBIN LOCUS REGULATION BY YAC TRANSFER
    NIH K11HL002711Mar 1, 1992 - Jul 31, 1997
    Role: Principal Investigator
    NORTHERN CALIFORNIA COMPREHENSIVE SICKLE CELL CENTER
    NIH P60HL020985Apr 1, 1978 - Mar 31, 2004
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Mannis GN, Martin TG, Damon LE, Andreadis C, Olin RL, Kong KA, Faham M, Hwang J, Ai WZ, Gaensler K, Sayre PH, Wolf JL, Logan AC. Quantification of Acute Lymphoblastic Leukemia Clonotypes in Leukapheresed Peripheral Blood Progenitor Cells Predicts Relapse Risk after Autologous Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2016 Jun; 22(6):1030-1036. PMID: 26899561.
      View in: PubMed
    2. Mannis GN, Martin TG, Damon LE, Logan AC, Olin RL, Flanders MD, Ai WZ, Gaensler K, Kaplan LD, Sayre PH, Smith CC, Wolf JL, Andreadis C. Long-term outcomes of patients with intermediate-risk acute myeloid leukemia treated with autologous hematopoietic cell transplant in first complete remission. Leuk Lymphoma. 2016 07; 57(7):1560-6. PMID: 26490487.
      View in: PubMed
    3. Ikuta T, Sellak H, Odo N, Adekile AD, Gaensler K. Nitric Oxide-cGMP Signaling Stimulates Erythropoiesis through Multiple Lineage-Specific Transcription Factors: Clinical Implications and a Novel Target for Erythropoiesis. PLoS One. 2016; 11(1):e0144561. PMID: 26727002; PMCID: PMC4699757.
    4. Li B, Luo X, Deng B, Wang J, McComb DW, Shi Y, Gaensler K, Tan X, Dunn AL, Kerlin BA, Dong Y. An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo. Nano Lett. 2015 Dec 09; 15(12):8099-107. PMID: 26529392; PMCID: PMC4869688.
    5. Tye GJ, Ioannou K, Amofah E, Quartey-Papafio R, Westrop SJ, Krishnamurthy P, Noble A, Harrison PM, Gaensler K, Barber LD, Farzaneh F. The combined molecular adjuvant CASAC enhances the CD8+ T cell response to a tumor-associated self-antigen in aged, immunosenescent mice. Immun Ageing. 2015; 12:6. PMID: 26157468; PMCID: PMC4495856.
    6. Greenberg PL, Stone RM, Bejar R, Bennett JM, Bloomfield CD, Borate U, De Castro CM, Deeg HJ, DeZern AE, Fathi AT, Frankfurt O, Gaensler K, Garcia-Manero G, Griffiths EA, Head D, Klimek V, Komrokji R, Kujawski LA, Maness LJ, O'Donnell MR, Pollyea DA, Scott B, Shami PJ, Stein BL, Westervelt P, Wheeler B, Shead DA, Smith C. Myelodysplastic syndromes, version 2.2015. J Natl Compr Canc Netw. 2015 Mar; 13(3):261-72. PMID: 25736003; PMCID: PMC4696005.
    7. Mannis GN, Andreadis C, Logan AC, Damon LE, Benet LZ, Ai WZ, Gaensler K, Kaplan LD, Koplowicz YB, Linker CA, Olin RL, Sayre PH, Smith CC, Sudhindra A, Venstrom JM, Wolf JL, Martin TG. A phase I study of targeted, dose-escalated intravenous busulfan in combination with etoposide as myeloablative therapy for autologous stem cell transplantation in acute myeloid leukemia. Clin Lymphoma Myeloma Leuk. 2015 Jun; 15(6):377-83. PMID: 25776193.
      View in: PubMed
    8. Keller JW, Andreadis C, Damon LE, Kaplan LD, Martin TG, Wolf JL, Ai WZ, Venstrom JM, Smith CC, Gaensler K, Hwang J, Olin RL. Hematopoietic cell transplantation comorbidity index (HCT-CI) is predictive of adverse events and overall survival in older allogeneic transplant recipients. J Geriatr Oncol. 2014 Jul; 5(3):238-44. PMID: 24894413.
      View in: PubMed
    9. Ito M, Ohba S, Gaensler K, Ronen SM, Mukherjee J, Pieper RO. Early Chk1 phosphorylation is driven by temozolomide-induced, DNA double strand break- and mismatch repair-independent DNA damage. PLoS One. 2013; 8(5):e62351. PMID: 23667469; PMCID: PMC3646831.
    10. Falahati R, Zhang J, Flebbe-Rehwaldt L, Shi Y, Gerson SL, Gaensler K. Chemoselection of allogeneic HSC after murine neonatal transplantation without myeloablation or post-transplant immunosuppression. Mol Ther. 2012 Nov; 20(11):2180-9. PMID: 22871662; PMCID: PMC3498795.
    11. Mintz PJ, Sætrom P, Reebye V, Lundbæk MB, Lao K, Rossi JJ, Gaensler K, Kasahara N, Nicholls JP, Jensen S, Haoudi A, Emara MM, Gordon MY, Habib NA. MicroRNA-181a* Targets Nanog in a Subpopulation of CD34(+) Cells Isolated From Peripheral Blood. Mol Ther Nucleic Acids. 2012 Aug 07; 1:e34. PMID: 23344176; PMCID: PMC3437805.
    12. Alhashem YN, Vinjamur DS, Basu M, Klingmüller U, Gaensler K, Lloyd JA. Transcription factors KLF1 and KLF2 positively regulate embryonic and fetal beta-globin genes through direct promoter binding. J Biol Chem. 2011 Jul 15; 286(28):24819-27. PMID: 21610079; PMCID: PMC3137057.
    13. Hacke K, Falahati R, Flebbe-Rehwaldt L, Kasahara N, Gaensler K. Suppression of HLA expression by lentivirus-mediated gene transfer of siRNA cassettes and in vivo chemoselection to enhance hematopoietic stem cell transplantation. Immunol Res. 2009; 44(1-3):112-26. PMID: 19048410; PMCID: PMC2938774.
    14. Keys JR, Tallack MR, Zhan Y, Papathanasiou P, Goodnow CC, Gaensler K, Crossley M, Dekker J, Perkins AC. A mechanism for Ikaros regulation of human globin gene switching. Br J Haematol. 2008 May; 141(3):398-406. PMID: 18318763.
      View in: PubMed
    15. Rupon JW, Wang SZ, Gaensler K, Lloyd J, Ginder GD. Methyl binding domain protein 2 mediates gamma-globin gene silencing in adult human betaYAC transgenic mice. Proc Natl Acad Sci U S A. 2006 Apr 25; 103(17):6617-22. PMID: 16608912; PMCID: PMC1458932.
    16. Basu P, Morris PE, Haar JL, Wani MA, Lingrel JB, Gaensler K, Lloyd JA. KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic beta-like globin genes in vivo. Blood. 2005 Oct 01; 106(7):2566-71. PMID: 15947087; PMCID: PMC1895257.
    17. Lipshutz GS, Titre D, Brindle M, Bisconte AR, Contag CH, Gaensler K. Comparison of gene expression after intraperitoneal delivery of AAV2 or AAV5 in utero. Mol Ther. 2003 Jul; 8(1):90-8. PMID: 12842432.
      View in: PubMed
    18. Gaensler K, Zhang Z, Lin C, Yang S, Hardt K, Flebbe-Rehwaldt L. Sequences in the (A)gamma-delta intergenic region are not required for stage-specific regulation of the human beta-globin gene locus. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3374-9. PMID: 12629213; PMCID: PMC152300.