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Karin Gaensler, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentMedicine
Address505 Parnassus Avenue
San Francisco CA 94117
Phone415-502-4390
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPost-Doc Fellow/Scholar1988 Medicine (Cancer Research Institute)
    University of California, San Francisco Residency
    Harvard UniversityM.D.1981School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Efficacy and safety of novel CD80 IL15 IL15Ra expressing autologous AML vaccines
    NIH R21CA177284Aug 6, 2013 - Jul 31, 2015
    Role: Principal Investigator
    Lentivirus-based positive/negative selection in minimally ablative transplants
    NIH R01HL107974Dec 1, 2011 - Nov 30, 2015
    Role: Principal Investigator
    Neonatal Chemoselection Following Ex Vivo Gene Transfer For Hereditary Disorders
    NIH R01HL082665May 12, 2008 - Apr 30, 2013
    Role: Principal Investigator
    Tolerance Induction by Neonatal Gene Delivery
    NIH R01DK072537Apr 15, 2006 - Apr 14, 2012
    Role: Principal Investigator
    In Vivo Stem Cell Selection in Neonatal Allo-Transplants
    NIH R21DK069430Sep 20, 2005 - Aug 31, 2008
    Role: Principal Investigator
    SEQUENTIAL PRE AND POSTNATAL GENE THERAPY OF HEMOPHILIA
    NIH R01HL062389Sep 1, 1999 - Aug 31, 2004
    Role: Principal Investigator
    GENE THERAPY STRATEGIES FOR SICKLE CELL DISEASE
    NIH/NHLBI P01HL053762Sep 30, 1994 - Aug 31, 2007
    Role: Co-Investigator
    ANALYSIS OF B GLOBIN LOCUS REGULATION BY YAC TRANSFER
    NIH K11HL002711Mar 1, 1992 - Jul 31, 1997
    Role: Principal Investigator
    NORTHERN CALIFORNIA COMPREHENSIVE SICKLE CELL CENTER
    NIH P60HL020985Apr 1, 1978 - Mar 31, 2004
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Greenberg PL, Stone RM, Al-Kali A, Barta SK, Bejar R, Bennett JM, Carraway H, De Castro CM, Deeg HJ, DeZern AE, Fathi AT, Frankfurt O, Gaensler K, Garcia-Manero G, Griffiths EA, Head D, Horsfall R, Johnson RA, Juckett M, Klimek VM, Komrokji R, Kujawski LA, Maness LJ, O'Donnell MR, Pollyea DA, Shami PJ, Stein BL, Walker AR, Westervelt P, Zeidan A, Shead DA, Smith C. Myelodysplastic Syndromes, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2017 Jan; 15(1):60-87. PMID: 28040720.
      View in: PubMed
    2. Mannis GN, Martin TG, Damon LE, Andreadis C, Olin RL, Kong KA, Faham M, Hwang J, Ai WZ, Gaensler K, Sayre PH, Wolf JL, Logan AC. Quantification of Acute Lymphoblastic Leukemia Clonotypes in Leukapheresed Peripheral Blood Progenitor Cells Predicts Relapse Risk after Autologous Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2016 Jun; 22(6):1030-1036. PMID: 26899561.
      View in: PubMed
    3. Mannis GN, Martin TG, Damon LE, Logan AC, Olin RL, Flanders MD, Ai WZ, Gaensler K, Kaplan LD, Sayre PH, Smith CC, Wolf JL, Andreadis C. Long-term outcomes of patients with intermediate-risk acute myeloid leukemia treated with autologous hematopoietic cell transplant in first complete remission. Leuk Lymphoma. 2016 Jul; 57(7):1560-6. PMID: 26490487.
      View in: PubMed
    4. Ikuta T, Sellak H, Odo N, Adekile AD, Gaensler K. Nitric Oxide-cGMP Signaling Stimulates Erythropoiesis through Multiple Lineage-Specific Transcription Factors: Clinical Implications and a Novel Target for Erythropoiesis. PLoS One. 2016; 11(1):e0144561. PMID: 26727002; PMCID: PMC4699757.
    5. Li B, Luo X, Deng B, Wang J, McComb DW, Shi Y, Gaensler K, Tan X, Dunn AL, Kerlin BA, Dong Y. An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo. Nano Lett. 2015 Dec 09; 15(12):8099-107. PMID: 26529392; PMCID: PMC4869688.
    6. Greenberg PL, Stone RM, Bejar R, Bennett JM, Bloomfield CD, Borate U, De Castro CM, Deeg HJ, DeZern AE, Fathi AT, Frankfurt O, Gaensler K, Garcia-Manero G, Griffiths EA, Head D, Klimek V, Komrokji R, Kujawski LA, Maness LJ, O'Donnell MR, Pollyea DA, Scott B, Shami PJ, Stein BL, Westervelt P, Wheeler B, Shead DA, Smith C. Myelodysplastic syndromes, version 2.2015. J Natl Compr Canc Netw. 2015 Mar; 13(3):261-72. PMID: 25736003; PMCID: PMC4696005.
    7. Mannis GN, Andreadis C, Logan AC, Damon LE, Benet LZ, Ai WZ, Gaensler K, Kaplan LD, Koplowicz YB, Linker CA, Olin RL, Sayre PH, Smith CC, Sudhindra A, Venstrom JM, Wolf JL, Martin TG. A phase I study of targeted, dose-escalated intravenous busulfan in combination with etoposide as myeloablative therapy for autologous stem cell transplantation in acute myeloid leukemia. Clin Lymphoma Myeloma Leuk. 2015 Jun; 15(6):377-83. PMID: 25776193.
      View in: PubMed
    8. Barzel A, Paulk NK, Shi Y, Huang Y, Chu K, Zhang F, Valdmanis PN, Spector LP, Porteus MH, Gaensler K, Kay MA. Promoterless gene targeting without nucleases ameliorates haemophilia B in mice. Nature. 2015 Jan 15; 517(7534):360-4. PMID: 25363772; PMCID: PMC4297598.
    9. Mannis GN, Logan AC, Leavitt AD, Yanada M, Hwang J, Olin RL, Damon LE, Andreadis C, Ai WZ, Gaensler K, Greene CC, Gupta NK, Kaplan LD, Mahindra A, Miyazaki Y, Naoe T, Ohtake S, Sayre PH, Smith CC, Venstrom JM, Wolf JL, Caballero L, Emi N, Martin TG. Delayed hematopoietic recovery after auto-SCT in patients receiving arsenic trioxide-based therapy for acute promyelocytic leukemia: a multi-center analysis. Bone Marrow Transplant. 2015 Jan; 50(1):40-4. PMID: 25243620.
      View in: PubMed
    10. Keller JW, Andreadis C, Damon LE, Kaplan LD, Martin TG, Wolf JL, Ai WZ, Venstrom JM, Smith CC, Gaensler K, Hwang J, Olin RL. Hematopoietic cell transplantation comorbidity index (HCT-CI) is predictive of adverse events and overall survival in older allogeneic transplant recipients. J Geriatr Oncol. 2014 Jul; 5(3):238-44. PMID: 24894413.
      View in: PubMed
    11. Shi Y, Falahati R, Zhang J, Flebbe-Rehwaldt L, Gaensler K. Role of antigen-specific regulatory CD4+CD25+ T cells in tolerance induction after neonatal IP administration of AAV-hF.IX. Gene Ther. 2013 Oct; 20(10):987-96. PMID: 23759700; PMCID: PMC3795474.
    12. Ito M, Ohba S, Gaensler K, Ronen SM, Mukherjee J, Pieper RO. Early Chk1 phosphorylation is driven by temozolomide-induced, DNA double strand break- and mismatch repair-independent DNA damage. PLoS One. 2013; 8(5):e62351. PMID: 23667469; PMCID: PMC3646831.
    13. Falahati R, Zhang J, Flebbe-Rehwaldt L, Shi Y, Gerson SL, Gaensler K. Chemoselection of allogeneic HSC after murine neonatal transplantation without myeloablation or post-transplant immunosuppression. Mol Ther. 2012 Nov; 20(11):2180-9. PMID: 22871662; PMCID: PMC3498795.
    14. Mintz PJ, Sætrom P, Reebye V, Lundbæk MB, Lao K, Rossi JJ, Gaensler K, Kasahara N, Nicholls JP, Jensen S, Haoudi A, Emara MM, Gordon MY, Habib NA. MicroRNA-181a* Targets Nanog in a Subpopulation of CD34(+) Cells Isolated From Peripheral Blood. Mol Ther Nucleic Acids. 2012 Aug 07; 1:e34. PMID: 23344176; PMCID: PMC3437805.
    15. Alhashem YN, Vinjamur DS, Basu M, Klingmüller U, Gaensler K, Lloyd JA. Transcription factors KLF1 and KLF2 positively regulate embryonic and fetal beta-globin genes through direct promoter binding. J Biol Chem. 2011 Jul 15; 286(28):24819-27. PMID: 21610079; PMCID: PMC3137057.
    16. Hacke K, Falahati R, Flebbe-Rehwaldt L, Kasahara N, Gaensler K. Suppression of HLA expression by lentivirus-mediated gene transfer of siRNA cassettes and in vivo chemoselection to enhance hematopoietic stem cell transplantation. Immunol Res. 2009; 44(1-3):112-26. PMID: 19048410; PMCID: PMC2938774.
    17. Damon L, Damon LE, Gaensler K, Kaplan L, Martin T, Rubenstein J, Linker C. Impact of intensive PBSC mobilization therapy on outcomes following auto-SCT for non-Hodgkin's lymphoma. Bone Marrow Transplant. 2008 Nov; 42(10):649-57. PMID: 18679366; PMCID: PMC4372391.
    18. Keys JR, Tallack MR, Zhan Y, Papathanasiou P, Goodnow CC, Gaensler K, Crossley M, Dekker J, Perkins AC. A mechanism for Ikaros regulation of human globin gene switching. Br J Haematol. 2008 May; 141(3):398-406. PMID: 18318763.
      View in: PubMed
    19. Rupon JW, Wang SZ, Gaensler K, Lloyd J, Ginder GD. Methyl binding domain protein 2 mediates gamma-globin gene silencing in adult human betaYAC transgenic mice. Proc Natl Acad Sci U S A. 2006 Apr 25; 103(17):6617-22. PMID: 16608912; PMCID: PMC1458932.
    20. Basu P, Morris PE, Haar JL, Wani MA, Lingrel JB, Gaensler K, Lloyd JA. KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic beta-like globin genes in vivo. Blood. 2005 Oct 01; 106(7):2566-71. PMID: 15947087; PMCID: PMC1895257.
    21. Lipshutz GS, Titre D, Brindle M, Bisconte AR, Contag CH, Gaensler K. Comparison of gene expression after intraperitoneal delivery of AAV2 or AAV5 in utero. Mol Ther. 2003 Jul; 8(1):90-8. PMID: 12842432.
      View in: PubMed
    22. Gaensler K, Zhang Z, Lin C, Yang S, Hardt K, Flebbe-Rehwaldt L. Sequences in the (A)gamma-delta intergenic region are not required for stage-specific regulation of the human beta-globin gene locus. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3374-9. PMID: 12629213; PMCID: PMC152300.
    23. Lipshutz GS, Gruber CA, Hardy J, Contag CH, Gaensler K. In utero delivery of adeno-associated viral vectors: intraperitoneal gene transfer produces long-term expression. Mol Ther. 2001 Mar; 3(3):284-92. PMID: 11273769.
      View in: PubMed
    24. Lipshutz GS, Flebbe-Rehwaldt L, Gaensler K. Reexpression following readministration of an adenoviral vector in adult mice after initial in utero adenoviral administration. Mol Ther. 2000 Oct; 2(4):374-80. PMID: 11020353.
      View in: PubMed
    25. May C, Rivella S, Callegari J, Heller G, Gaensler K, Luzzatto L, Sadelain M. Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin. Nature. 2000 Jul 06; 406(6791):82-6. PMID: 10894546.
      View in: PubMed
    26. Gaensler K, Tu G, Bruch S, Liggitt D, Lipshutz GS, Metkus A, Harrison M, Heath TD, Debs RJ. Fetal gene transfer by transuterine injection of cationic liposome-DNA complexes. Nat Biotechnol. 1999 Dec; 17(12):1188-92. PMID: 10585716.
      View in: PubMed
    27. Lipshutz GS, Sarkar R, Flebbe-Rehwaldt L, Kazazian H, Gaensler K. Short-term correction of factor VIII deficiency in a murine model of hemophilia A after delivery of adenovirus murine factor VIII in utero. Proc Natl Acad Sci U S A. 1999 Nov 09; 96(23):13324-9. PMID: 10557319; PMCID: PMC23946.
    28. Lipshutz GS, Flebbe-Rehwaldt L, Gaensler K. Adenovirus-mediated gene transfer to the peritoneum and hepatic parenchyma of fetal mice in utero. Surgery. 1999 Aug; 126(2):171-7. PMID: 10455880.
      View in: PubMed
    29. Lipshutz GS, Flebbe-Rehwaldt L, Gaensler K. Adenovirus-mediated gene transfer in the midgestation fetal mouse. J Surg Res. 1999 Jun 15; 84(2):150-6. PMID: 10357912.
      View in: PubMed
    30. Chang JC, Lu R, Lin C, Xu SM, Kan YW, Porcu S, Carlson E, Kitamura M, Yang S, Flebbe-Rehwaldt L, Gaensler K. Transgenic knockout mice exclusively expressing human hemoglobin S after transfer of a 240-kb betas-globin yeast artificial chromosome: A mouse model of sickle cell anemia. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14886-90. PMID: 9843985; PMCID: PMC24545.
    31. Porcu S, Kitamura M, Witkowska E, Zhang Z, Mutero A, Lin C, Chang J, Gaensler K. The human beta globin locus introduced by YAC transfer exhibits a specific and reproducible pattern of developmental regulation in transgenic mice. Blood. 1997 Dec 01; 90(11):4602-9. PMID: 9373272.
      View in: PubMed
    32. Perkins AC, Gaensler K, Orkin SH. Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF. Proc Natl Acad Sci U S A. 1996 Oct 29; 93(22):12267-71. PMID: 8901569; PMCID: PMC37979.
    33. Liu Y, Liggitt D, Zhong W, Tu G, Gaensler K, Debs R. Cationic liposome-mediated intravenous gene delivery. J Biol Chem. 1995 Oct 20; 270(42):24864-70. PMID: 7559609.
      View in: PubMed
    34. Gaensler K, Kitamura M, Kan YW. Germ-line transmission and developmental regulation of a 150-kb yeast artificial chromosome containing the human beta-globin locus in transgenic mice. Proc Natl Acad Sci U S A. 1993 Dec 01; 90(23):11381-5. PMID: 8248258; PMCID: PMC47986.
    35. Stribling R, Brunette E, Liggitt D, Gaensler K, Debs R. Aerosol gene delivery in vivo. Proc Natl Acad Sci U S A. 1992 Dec 01; 89(23):11277-81. PMID: 1454808; PMCID: PMC50533.
    36. Debs R, Pian M, Gaensler K, Clements J, Friend DS, Dobbs L. Prolonged transgene expression in rodent lung cells. Am J Respir Cell Mol Biol. 1992 Oct; 7(4):406-13. PMID: 1327013.
      View in: PubMed
    37. Gaensler K, Burmeister M, Brownstein BH, Taillon-Miller P, Myers RM. Physical mapping of yeast artificial chromosomes containing sequences from the human beta-globin gene region. Genomics. 1991 Aug; 10(4):976-84. PMID: 1916829.
      View in: PubMed
    38. Myers RM, Cowie A, Stuve L, Hartzog G, Gaensler K. Genetic and biochemical analysis of the mouse beta-major globin promoter. Prog Clin Biol Res. 1989; 316A:117-27. PMID: 2594802.
      View in: PubMed
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